[Regression of cytomegalovirus retinitis in AIDS patients without systemic maintenance anti-cytomegalovirus therapy treated with highly active antiretroviral therapy]

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

[Regression of cytomegalovirus retinitis in AIDS patients without systemic maintenance anti-cytomegalovirus therapy treated with highly active antiretroviral therapy]

Ophthalmologe. 1999 Dec;96(12):829-31. Unique Identifier : AIDSLINE MED/20107930
Schaller UC; Walli RK; Mueller AJ; Klauss V; Universitats-Augenklinik Munchen.

Abstract: BACKGROUND: The purpose of this study was to evaluate the course of CMV retinitis after initiation of highly active antiretroviral therapy (HAART) and discontinuation of systemic anti-CMV maintenance therapy. PATIENTS AND METHODS: Case reports are presented for two AIDS patients (2 eyes, ages 34, 43, male) with CMV retinitis. The CD4 count at the time of CMV retinitis was 20/microliter (patient 1) and 35/microliter (patient 2). Under HAART the CD4 count rose up to 202/microliter (patient 1) and 350/microliter (patient 2); the viral load was under detection limit in both patients. At that time systemic maintenance therapy was discontinued in both patients. RESULTS: There was no progression of retinitis during the observation period of 21 months (patient 1) and 24 months (patient 2). CONCLUSIONS: In selected patients with immune recovery under HAART it is possible to discontinue systemic anti-CMV maintenance therapy.

Keywords: JOURNAL ARTICLE systemische Anti-Zytomegalievirus-Erhaltungstherapie unter hochaktiver antiretroviraler Therapie (HAART). Adult Anti-HIV Agents/*ADMINISTRATION & DOSAGE/ADVERSE EFFECTS AIDS-Related Opportunistic Infections/DIAGNOSIS/*DRUG THERAPY Case Report Cytomegalovirus Retinitis/DIAGNOSIS/*DRUG THERAPY Drug Therapy, Combination English Abstract Fluorescein Angiography Human HIV-1/*DRUG EFFECTS Male Treatment Outcome
000530
A0052211

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