Critical role of nitric oxide during the apoptosis of peripheral blood leukocytes from patients with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Critical role of nitric oxide during the apoptosis of peripheral blood leukocytes from patients with AIDS.

Unique Identifier : AIDSLINE MED/20133091
Mossalayi MD; Becherel PA; Debre P


Abstract: BACKGROUND: Highly active antiretroviral therapies (HAART) increase the CD4(+) cell count, but complete normalization of this parameter has not been obtained in some patients. As oxidative stress plays an important role during human immunodeficiency virus type 1 (HIV-1)-associated dementia and lymphocyte apoptosis, we asked whether the nitric oxide (NO) pathway plays a role in the in vitro survival of peripheral blood mononuclear cells (PBMC) from HIV-1(+) patients and how it
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