Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Cancer Lett. 1999 Dec 1;147(1-2):215-9. Unique Identifier : AIDSLINE MED/20123505
Yamada Y; Sugahara K; Tsuruda K; Nohda K; Hata T; Maeda T; Honda M; Tawara M; Hayashibara T; Joh T; Tomonaga M; Miyazaki Y; Kamihira S; Department of Laboratory Medicine, Nagasaki University School of; Medicine, Japan.
Abstract: A preventive role for human T-cell leukemia virus type-I (HTLV-I) and Fas-associated phosphatase-1 (FAP-1) in Fas-mediated apoptosis has been reported in HTLV-I-infected cells. In the present study, we examined whether these molecules increased during the acquisition of Fas-resistance in adult T-cell leukemia (ATL) cell lines. SO4, ST1 and KK1 are Fas-sensitive ATL cell lines, and produce small amounts of HTLV-I in vitro. Although their subclones RSO4 and RST1 are completely Fas-resistant, they produced an equivalent amount of HTLV-I to SO4 and ST1. Moreover, FAP-1 mRNA was not detected in these cell lines irrespective of Fas sensitivity. Thus, Fas resistance in ATL cells was not directly associated with the increased production of HTLV-I or FAP-1.
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