Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Clin Exp Immunol. 2000 Feb;119(2):259-63. Unique Identifier : AIDSLINE MED/20098463
Araki K; Harada K; Nakamoto K; Shiroma M; Miyakuni T; Department of Medical Technology, School of Health Science,; Faculty of Medicine, University of the Ryukyu, Japan.; karaki@med.u-ryukyu.ac.jp
Abstract: The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the smouldering type. The level for asymptomatic HTLV-1 carriers was 475 U/ml, and 165 U/ml for healthy young adult HTLV-1- controls. The serial measurement of sIL-2R in ATL patients, healthy HTLV-1 carriers, and HTLV-1 carriers with diseases other than ATL showed a good correlation between serum levels of sIL-2R and the pathophysiological status of disease. Furthermore, an increase in the sIL-2Ralpha level in serum indicated the exacerbation of HTLV-1 infection and autoimmune diseases. The measurement of sIL-2Ralpha levels is therefore a very useful parameter for determining disease status.
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