Meta-analysis of antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Meta-analysis of antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death.

Antivir Ther. 1998;3(3):139-45. Unique Identifier : AIDSLINE MED/20146712
Hill AM; DeMasi R; Dawson D; GlaxoWellcome, Greenford, Middlesex, UK. AMH21137@GGR.CO.UK

Abstract: There is uncertainty as to how the effects of antiretroviral treatments on human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4 cell counts can predict reductions in clinical progression to AIDS or death. A meta-analysis was conducted for 27 pairwise comparisons of antiretroviral treatments in 15 randomized trials of antiretroviral treatments. For each trial, three measures of treatment effect were used: (i) 16 week change from baseline in HIV-1 RNA; (ii) 16 week change from baseline in CD4 cell count; and (iii) rate of clinical progression. Treatments which caused greater increases in CD4 cell count and greater reductions in HIV-1 RNA were more effective at reducing the rate of clinical progression (P < 0.05 for each comparison). However, there was variability in the consistency of this correlation between different trials and treatments. The results support the use of both CD4 count and HIV-1 RNA levels as the primary markers of the efficacy of antiretroviral treatment.

Keywords: JOURNAL ARTICLE META-ANALYSIS Acquired Immunodeficiency Syndrome/*DRUG THERAPY/IMMUNOLOGY/ VIROLOGY Anti-HIV Agents/*THERAPEUTIC USE *CD4 Lymphocyte Count Human HIV-1/*DRUG EFFECTS/GENETICS RNA, Viral/*ANALYSIS
000530
A0052160

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