Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy.

J Infect Dis. 2000 Jan;181(1):354-7. Unique Identifier : AIDSLINE MED/20087035
Schacker T; Little S; Connick E; Gebhard-Mitchell K; Zhang ZQ; Krieger J; Pryor J; Havlir D; Wong JK; Richman D; Corey L; Haase AT; Department of Medicine/Infectious Diseases, University of; Minnesota, 216 Delaware St., Minneapolis, MN 55455, USA.; schacker@lenti.med.umn.edu

Abstract: The follicular dendritic cell network (FDC) in lymphoid tissues (LTs) is the major site of human immunodeficiency virus (HIV) storage in presymptomatic and late stages of disease. However, little is known about the rate of virus accumulation during the acute and early stages. In situ hybridization and quantitative image analysis were used to determine the amount of virus bound to the FDC network during the first year of infection. The FDC pool was already >7.0 log10 copies of HIV RNA/g LT in the first year, and 2 patients biopsied within 2-4 days of symptom onset had 7.3 and 8.2 log10 copies of HIV RNA/g LT, respectively. There was no correlation between duration of infection and accumulation of HIV into the FDC network. These data suggest that a large pool of infectious virus is established soon after infection and that initiation of antiretroviral therapy when symptoms of primary HIV infection are recognized is unlikely to prevent substantial accumulation of virus in the FDC network.

Keywords: JOURNAL ARTICLE MULTICENTER STUDY Acute Disease Antiviral Agents/*THERAPEUTIC USE Dendritic Cells, Follicular/*VIROLOGY Female Germinal Center Human HIV Infections/*DRUG THERAPY/*VIROLOGY HIV-1/*GROWTH & DEVELOPMENT Image Processing, Computer-Assisted In Situ Hybridization Lymphoid Tissue/*VIROLOGY Male Support, U.S. Gov't, P.H.S. Time Factors
000530
A0051853

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