2000
- The role of CD4 and CD8 T cells in the development of autoimmune diabetes.
- J Autoimmun. 1999 Nov;13(3):285-90. Unique Identifier : AIDSLINE MED/20019749
- Dilts SM; Solvason N; Lafferty KJ; The John Curtin School of Medical Research, Division of Molecular; Medicine, Australian National University, Canberra, ACT, 0200,; Australia.
- The role of CD4 vs. CD8 T cells in IDDM.
- J Autoimmun. 1999 Nov;13(3):290-5. Unique Identifier : AIDSLINE MED/20019750
- Wong FS; Janeway CA Jr; Section of Immunobiology and Howard Hughes Medical Institute,; Yale School of Medicine, New Haven, CT, 06520-8011, USA.
- Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen.
- Unique Identifier : AIDSLINE MED/20019753
- Garcia G; Komagata Y; Slavin AJ; Maron R; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital,; Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA,; 02115, USA.
- We directly compared the effects of oral and nasal administration of collagen type II (CII) on disease progression, cytokine production and T cell responses in DBA/1 mice. Lymphocytes were assayed for proliferation and cytokine production and cell lines established. T cells from fed or nasally treated groups prolifera
- Anti-phospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome: comparisons of phospholipid specificity, avidity and reactivity with beta2-GPI.
- J Autoimmun. 1999 Nov;13(3):347-55. Unique Identifier : AIDSLINE MED/20019756
- Petrovas C; Vlachoyiannopoulos PG; Kordossis T; Moutsopoulos HM; Department of Pathophysiology, Medical School, National; University of Athens, Athens, Greece.
- Increased prevalence of anti-phospholipid antibodies (aPL) and increased levels of lipid peroxidation have been described in patients with HIV infection. To assess the binding specificity and avidity of aPL antibodies in HIV infection, sera from 44 HIV-1 infected patients were evaluated for antibodies to cardiolipin (
- Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells?
- J Autoimmun. 1999 Dec;13(4):373-82. Unique Identifier : AIDSLINE MED/20054046
- Radosevic K; Casteels KM; Mathieu C; Van Ewijk W; Drexhage HA; Leenen PJ; Department of Immunology, Erasmus University Rotterdam, The; Netherlands. radosevic@immu.fgg.eur.nl
- In this study we have tried to detect abnormalities in the immunophenotype and/or function of dendritic cells from the non-obese diabetic mouse (NOD DC), that might be related to islet autoimmunity. The immunophenotype of NOD splenic DC did not show significant abnormalities as compared with the immunophenotype of spl
- Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-gamma secretion pathway.
- J Autoimmun. 1999 Dec;13(4):383-92. Unique Identifier : AIDSLINE MED/20054047
- Ablamunits V; Quintana F; Reshef T; Elias D; Cohen IR; Department of Immunology, The Weizmann Institute of Science,; Rehovot, 76100, Israel.
- Cyclophosphamide (CY), an alkylating cytostatic drug, is known for its ability to accelerate a number of experimental autoimmune diseases including spontaneous diabetes in NOD mice. The mechanism(s) by which CY renders autoreactive lymphocytes more pathogenic is largely unknown, but it has been postulated that the dru
- Suppression of systemic lupus erythematosus disease in mice by oral administration of kidney extract.
- J Autoimmun. 1999 Dec;13(4):405-14. Unique Identifier : AIDSLINE MED/20054049
- Ofosu-Appiah W; Sfeir G; Viti D; Burashnikova E; Department of Immunology, Masonic Medical Research Laboratory,; Utica, NY 13501, USA. ofosu@mmrl.edu
- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increased production of antibodies reactive with a variety of self and non-self antigens. A number of immunomodulatory therapies have been investigated for the disease process. Intragastric administration of low dose kidney extract (KE) t
- Intracytoplasmic Th1 and Th2 cytokines in rheumatoid arthritis blood and synovial tissue.
- J Autoimmun. 1999 Dec;13(4):415-22. Unique Identifier : AIDSLINE MED/20054050
- Bourg V; Portales P; Fiorito S; Combe B; Jorgensen C; Sany J; Clot J; Laboratory of Immunology -INSERM U475, Saint-Eloi Hospital,; Montpellier, France.
- In rheumatoid arthritis (RA), T cells have been proposed either as a main actor or as an epiphenomenon in such a primarily synoviocyte-driven disease. A major issue remains the remarkable paradox between the T cell infiltrate and the relative failure to detect definite markers of their activity. To determine the Th1/T
- Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-type bias in normal pregnancy and pregnancy failure.
- Am J Reprod Immunol. 1999 Nov;42(5):273-81. Unique Identifier : AIDSLINE MED/20049676
- Makhseed M; Raghupathy R; Azizieh F; Al-Azemi MM; Hassan NA; Bandar A; Department of Obstetrics and Gynecology, Faculty of Medicine,; Kuwait University. abrar@hsc.kuniv.edu.kw
- PROBLEM: Profiles of Th1- and Th2-type cytokines were studied in women with a history of successful pregnancy and in women with a history of unexplained recurrent spontaneous abortions (RSA) with the objective of elucidating Th1- and Th2-type bias in normal pregnancy and pregnancy failure. METHOD OF STUDY: Peripheral
- Inhibitor of HIV-1 reverse transcriptase: N'-(5-bromo-2-pyridyl)-N-[2-(2,5-dimethoxyphenyl)ethyl]thiourea.
- Acta Crystallogr C. 1999 Dec 15;55 ( Pt 12):2122-4. Unique Identifier : AIDSLINE MED/20106037
- Sudbeck EA; Jennissen JD; Venkatachalam TK; Uckun FM; Department of Structural Biology, Hughes Institute, St Paul, MN; 55113, USA. esudbeck@ih.org
- The crystal structure of the title compound, C16H18Br-N3O2S (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase, revealed an intramolecular hydrogen bond between a thiourea N atom and the pyridyl-N atom [N-H...N = 2.671 (3) A, graph-set motif S1(1)(6)] that imparts a more rigid conformation to t
- Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: biological correlates of clinical outcome.
- Eur J Cancer. 1999 Dec;35(13):1809-15. Unique Identifier : AIDSLINE MED/20138951
- Cattelan AM; Calabro ML; Aversa SM; Zanchetta M; Meneghetti F; De Rossi A; Chieco-Bianchi L; Department of Infectious Diseases, General Hospital of Padova,; Italy.
- The clinical response of AIDS-related Kaposi s sarcoma (KS) to highly active antiretroviral therapy (HAART), a combination of human immunodeficiency virus type 1 (HIV-1) protease and reverse transcriptase inhibitors, was studied in 11 patients, all but one with progressive KS. CD4+ cell counts, plasma HIV-1 RNA levels
- Detection of antibodies to human herpesvirus 8 in Italian children: evidence for horizontal transmission.
- Br J Cancer. 2000 Feb;82(3):702-4. Unique Identifier : AIDSLINE MED/20144890
- Whitby D; Luppi M; Sabin C; Barozzi P; Di Biase AR; Balli F; Cucci F; Weiss RA; Boshoff C; Torelli G; Institute of Cancer Research, London, UK.
- Human herpesvirus 8 (HHV-8), also known as Kaposi s sarcoma associated herpesvirus (KSHV), has been shown to be the causative agent for Kaposi s sarcoma (KS) and to be more prevalent in populations or risk groups at increased risk for KS. HHV-8 infection is rare in children from the US and the UK, but has been reporte
- Human herpesvirus type 8 and epstein-barr virus-associated cutaneous lymphoma taking anaplastic large cell morphology in a man with HIV infection.
- Br J Dermatol. 1999 Jul;141(1):141-5. Unique Identifier : AIDSLINE MED/99348108
- Nakamura K; Katano H; Hoshino Y; Nakamura T; Hosono O; Masunaga A; Mori S; Iwamoto A; Tamaki K; Department of Dermatology, University of Tokyo, 7-3-1 Hongo,; Bunkyo-ku, Tokyo 113-0033, Japan. makamura-der@h.u-tokyo.ac.jp
- Human herpesvirus type 8 (HHV-8, Kaposi s sarcoma-associated herpesvirus)-positive lymphoma taking anaplastic large cell morphology in the skin is described in a 46-year-old man with AIDS. Multiple erythematous nodules appeared on the trunk and extremities during the treatment of AIDS. Histological examination of cuta
- Absence of a link between human herpesvirus 8 and pemphigus [letter]
- Br J Dermatol. 1999 Jul;141(1):159-60. Unique Identifier : AIDSLINE MED/99348114
- Dupin N; Marcelin AG; Calvez V; Andr C
- Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment.
- Unique Identifier : AIDSLINE MED/99348086
- Fearfield LA; Rowe A; Francis N; Bunker CB; Staughton RC
- The predominant itchy folliculitis associated with human immunodeficiency virus (HIV) infection appears to be an
- Evidence for the cofactor role of human T-cell lymphotropic virus type 1 in mycosis fungoides and Sezary syndrome.
- Br J Dermatol. 1999 Jul;141(1):44-9. Unique Identifier : AIDSLINE MED/99348091
- Shohat M; Hodak E; Hannig H; Bodemer W; David M; Shohat B; Department of Dermatology and Cellular Immunology Unit, Rabin; Medical Center, Petah Tiqva 49100, Israel and Deutsches; Primatenzentrum, Gottingen, Germany.
- The aetiology of mycosis fungoides (MF) and Sezary syndrome (SS) is unknown. A pathogenic role for the human T-cell lymphotropic virus type 1 (HTLV-1) has been suggested but remains controversial. We used an animal model to test the possibility that peripheral blood mononuclear cells (PBMC) obtained from MF patients h
- No evidence for a role of human herpesvirus type 8 in sarcoidosis: molecular and serological analysis.
- Br J Dermatol. 1999 Sep;141(3):492-6. Unique Identifier : AIDSLINE MED/20050136
- Lebbe C; Agbalika F; Flageul B; Pellet C; Rybojad M; Cordoliani F; Farge D; Vignon-Pennamen MD; Sheldon J; Morel P; Calvo F; Schulz TF; Department of Dermatology, Hopital Saint-Louis, Paris, France.
- The aim of this study was to analyse the association between human herpesvirus type 8 (HHV8) and sarcoidosis. Using nested polymerase chain reaction (PCR), we tested the presence of HHV8 DNA sequences in 13 skin specimens and peripheral blood mononuclear cells from eight patients suffering from sarcoidosis. We also lo
- Pneumocystis carinii pneumonia in patients receiving immunosuppressive drugs for dermatological diseases.
- Br J Dermatol. 1999 Sep;141(3):528-30. Unique Identifier : AIDSLINE MED/20050144
- Raychaudhuri SP; Siu S; Department of Medicine, Kaiser Permanente, Oakland, CA, USA.
- In recent years, Pneumocystis carinii pneumonia (PCP) has been increasingly reported in patients without human immunodeficiency virus (HIV) infection. The increased occurrence of PCP in non-HIV-immunocompromised subjects has been attributed to several factors: use of stronger immunosuppressive regimens, higher awarene
- Micrococcus folliculitis in HIV-1 disease.
- Br J Dermatol. 1999 Sep;141(3):558-61. Unique Identifier : AIDSLINE MED/20050152
- Smith KJ; Neafie R; Yeager J; Skelton HG; Departments of Dermatology and Pathology, National Naval Medical; Center, 8901 Wisconsin Avenue, Bethesda, MD 20889-5600, USA.; HSkelIII@aol.com
- Organisms with little pathogenic potential in immunocompetent hosts may produce disease in HIV-1 + patients. We describe three HIV-1 + patients in late disease who presented with pruritic papules with central ulceration over the face and arms. In all the patients the eruptions had been present for months, and the pati
- Evaluation of a drama-in-education programme to increase AIDS awareness in South African high schools: a randomized community intervention trial.
- Int J STD AIDS. 2000 Feb;11(2):105-11. Unique Identifier : AIDSLINE MED/20141946
- Harvey B; Stuart J; Swan T; AIDS Programme, KwaZulu Department of Health, South Africa.
- A community intervention trial was undertaken in KwaZulu Natal, South Africa to evaluate the effectiveness of a high school drama-in-education programme. Seven pairs of secondary schools were randomized to receive either written information about HIV/AIDS or the drama programme. Q
- Risk perception and counselling among HIV-positive women in Sao Paulo, Brazil.
- Int J STD AIDS. 2000 Feb;11(2):112-4. Unique Identifier : AIDSLINE MED/20141947
- Ventura-Filipe EM; Bugamelli LE; Leme B; Santos NJ; Garcia S; Paiva V; Hearst N; Programa Estadual de DST/AIDS de Sao Paulo (Sao Paulo State; STD/AIDS Programme), Brazil. efilipe@cebinet.com.br
- This study of HIV-positive women at a clinic for HIV/AIDS in Sao Paulo examined their risk perception for HIV before they had learned of their diagnosis and their experiences with pre- and post-test counselling. A sample of 148 women was interviewed regarding demographics, HIV risk factors and risk perception, pre- an
- Trend of antimicrobial resistance in Neisseria gonorrhoeae at New Delhi, India.
- Int J STD AIDS. 2000 Feb;11(2):115-8. Unique Identifier : AIDSLINE MED/20141948
- Ray K; Bala M; Kumar J; Misra RS; Regional STD Teaching, Training and Research Centre, Safdarjung; Hospital, New Delhi, India.
- We aim to monitor the trends of antimicrobial resistance in Neisseria gonorrhoeae and to compare the results of antimicrobial sensitivity by disc diffusion and minimum inhibitory concentration (MIC). Two hundred and eleven confirmed strains of N. gonorrhoeae were subjected to antimicrobial sensitivity testing by disc
- Lymphocytic interstitial pneumonitis in an HIV-infected adult: response to antiretroviral therapy.
- Int J STD AIDS. 2000 Feb;11(2):119-22. Unique Identifier : AIDSLINE MED/20141949
- Scarborough M; Lishman S; Shaw P; Fakoya A; Miller RF; HIV/AIDS Unit, UCL Hospitals Trust, London, UK.
- An annular erythema secondary to primary genital herpes.
- Int J STD AIDS. 2000 Feb;11(2):123-5. Unique Identifier : AIDSLINE MED/20141950
- Mahto M; Mandal D; Beck MH; Wells S; Bolton Centre for Sexual Health, Royal Bolton Hospital,; Farnworth, UK.
- Disseminated Penicillium marneffei in a patient infected with human immunodeficiency virus.
- Int J STD AIDS. 2000 Feb;11(2):126-8. Unique Identifier : AIDSLINE MED/20141951
- Vilar FJ; Hunt R; Wilkins EG; Wilson G; Jones NP; Department of Infectious Diseases and Tropical Medicine, North; Manchester General Hospital, UK.
- A case of a 31-year-old man with systemic Penicillium marneffei infection acquired in Thailand and who developed endophthalmitis is described. This presentation has not previously been reported. He responded to combined treatment with intravenous and intravitreal amphotericin.
- Sexual health knowledge of adolescents in a Great Yarmouth high school [letter]
- Int J STD AIDS. 2000 Feb;11(2):129-31. Unique Identifier : AIDSLINE MED/20141952
- Harry TC
- The need to exercise caution in the management of patients co-infected with HIV and hepatitis B [letter]
- Int J STD AIDS. 2000 Feb;11(2):131-2. Unique Identifier : AIDSLINE MED/20141953
- Joseph AT; Chandramani S; Cox M
- Four-drug salvage antiretroviral treatment including nelfinavir and efavirenz in highly treated children with congenital HIV disease [letter]
- Int J STD AIDS. 2000 Feb;11(2):132-3. Unique Identifier : AIDSLINE MED/20141954
- Manfredi R; Chiodo F
- Behavioural and biomedical risk factors for the transmission of HIV/AIDS in Bangladesh [letter]
- Int J STD AIDS. 2000 Feb;11(2):133-4. Unique Identifier : AIDSLINE MED/20141955
- Shah SA; Kristensen S; Khan OA
- The emerging AIDS crisis in Russia: review of enabling factors and prevention needs.
- Int J STD AIDS. 2000 Feb;11(2):71-5. Unique Identifier : AIDSLINE MED/20141940
- Kalichman SC; Kelly JA; Sikkema KJ; Koslov AP; Shaboltas A; Granskaya J; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Department of Psychiatry and Behavioral Medicine,; 53226, USA. sethk@mcw.edu
- Eastern Europe is experiencing increased rates of HIV/AIDS, and the Russian Federation is among the countries with the most alarming case rate increases. Behavioural and biological studies demonstrate that the transmission of HIV in Russia is occurring as a result of injection drug use, homosexual, and heterosexual ri
- Mycoplasma species in rapid and slow HIV progressors.
- Int J STD AIDS. 2000 Feb;11(2):76-9. Unique Identifier : AIDSLINE MED/20141941
- Ainsworth JG; Hourshid S; Easterbrook PJ; Gilroy CB; Weber JN; Taylor-obinson D; Division of Medicine, Imperial College School of Medicine, St; Mary's Hospital, London, UK.
- We determined the relationship between the presence of Mycoplasma fermentans and Mycoplasma penetrans and the rate of progression of HIV-associated disease in a nested case-control study based on a cohort of 159 HIV-infected patients with different rates of disease progression. Study participants were divided into 3 p
- Asymptomatic penile HPV infection: a prospective study.
- Int J STD AIDS. 2000 Feb;11(2):80-4. Unique Identifier : AIDSLINE MED/20141942
- Wikstrom A; Popescu C; Forslund O; Department of Dermatovenereology, Karolinska Hospital, Stockholm,; Sweden.
- The occurrence of human papillomavirus (HPV) among males was analysed with the polymerase chain reaction (PCR) method. Penile brush samples were taken once from 147 males attending for a control or for HPV non-related reasons, and consecutive samples were collected from 88 males re-attending the clinic. Of the males a
- Detection of human cytomegalovirus retinitis and monitoring of ganciclovir treatment using conjunctival swab with polymerase chain reaction in AIDS patients.
- Int J STD AIDS. 2000 Feb;11(2):85-91. Unique Identifier : AIDSLINE MED/20141943
- Chiou SH; Liu JH; Wong WW; Chan YJ; Chang YC; Wang JJ; Liu CY; Liu WT; Chen SC; Hsu WM; Department of Ophthalmology, Veterans General Hospital, Taipei,; Taiwan, Republic of China.
- This report studies the accuracy of conjunctival swab polymerase chain reaction (CS-PCR) for the diagnosis of human cytomegalovirus retinitis (HCMV) in AIDS patients. PCR and virus culture were used for the detection of HCMV in conjunctival swab, serum, and urine specimens from 38
- A survey of patients with Chlamydia trachomatis infection: sexual behaviour and perceptions about contact tracing.
- Int J STD AIDS. 2000 Feb;11(2):92-5. Unique Identifier : AIDSLINE MED/20141944
- Tyden T; Ramstedt K; Department of Public Health and Caring Sciences, University of; Uppsala, Sweden. tanja.tyden@vard.uu.se
- The aim of this study was to evaluate how patients with Chlamydia trachomatis infection perceived the legal enforcement of partner notification and to seek their views on legislation impinging on their own sexual behaviour. The investigation was performed at STD clinics in Stockholm, S
- Condom use and 'withdrawal': exploring gay men's practice of anal intercourse.
- Int J STD AIDS. 2000 Feb;11(2):96-104. Unique Identifier : AIDSLINE MED/20141945
- Richters J; Knox S; Crawford J; Kippax S; National Centre in HIV Social Research, University of New South; Wales, Sydney, Australia. j.richters@unsw.edu.au
- Some gay men who have unprotected anal intercourse avoid ejaculation-they practise withdrawal . Using data collected in 1997 from a sample of Sydney gay men (n=625), we explored the relation between men s practice of ejaculation and their use of condoms. We also investigated whether men who had unprotected withdrawal
- [Prevention of transmissible diseases. Work Group for Transmissible Diseases of the PAPPS]
- Aten Primaria. 1999 Dec;24 Suppl 1:99-117. Unique Identifier : AIDSLINE MED/20131580
- Pareja Bezares A; Alvarez Pasquin MJ; Batalla Martinez C; Comin Bertran E; Gomez Marco JJ; Nino Martin V; Pineiro Guerrero R
- Human obesity and thinness, hyperlipidemia, hyperglycemia, and insulin resistance associated with HIV1 protease inhibitors. Prevention by alternating several antiproteases in short sequences [editorial]
- Biomed Pharmacother. 1999 Dec;53(10):449-51. Unique Identifier : AIDSLINE MED/20128721
- Mathe G
- In 1997, and mainly in 1998 and 1999, a lipodystrophic syndrome with central obesity, peripheral fat loss, hyperlipidemia, hyperglycemia and insulin-resistant-diabetes II, was described as the most frequent manifestation of toxicity of HIV1 virostatic therapy, associated with
- In-vivo delivery of therapeutic proteins by genetically-modified cells: comparison of organoids and human serum albumin alginate-coated beads.
- Biomed Pharmacother. 1999 Dec;53(10):471-83. Unique Identifier : AIDSLINE MED/20128726
- Shinya E; Dervillez X; Edwards-Levy F; Duret V; Brisson E; Ylisastigui L; Levy MC; Cohen JH; Klatzmann D; Laboratoire de biologie et therapeutique des pathologies; immunitaires, UPMC/CNRS ESA 7087, Hopital de la; Pitie-Salpetriere, Paris, France.
- We have designed a self-assembling multimeric soluble CD4 molecule by inserting the C-terminal fragment of the alpha chain of human C4-binding protein (C4bp alpha) at the C-terminal end of human soluble CD4 genes. This CD4-C4bp alpha fusion protein (sMulti-CD4) and two other reference molecules, a fusion protein of hu
- Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment? A ten-year experiment must liberate them [editorial]
- Biomed Pharmacother. 1999 Dec;53(10):484-6. Unique Identifier : AIDSLINE MED/20128727
- Mathe G
- We detected in 1989, with the inhibitor test of proviral insertion into c-erb B erythroblastosis, two retrovirus integrase inhibitors: hydroxy-methyl-ellipticine and acriflavine. They have been used for ten years in AIDS patients with high efficacy and no toxicity. Since vitamin B12 and cobalt, which it contains, have
- Functional status of the immune system after chronic administration of 2'-deoxycoformycin in the BB rat.
- Unique Identifier : AIDSLINE MED/20133370
- Thliveris JA; HayGlass KT; Manchur D; Rector E; Begleiter A; Johnston JB; Department of Human Anatomy and Cell Science, University of; Manitoba, Winnipeg, Canada. thliver@ms.umanitoba.ca
- Insulin-dependent diabetes mellitus (IDDM) is caused by autoimmune destruction of pancreatic beta cells with the primary mechanism being cell mediated. The BB rat develops insulitis and IDDM with many features analogous to the disease in man. In previous studies we reported that weekly administration of 2 -deoxycoform
- [Regression of cytomegalovirus retinitis in AIDS patients without systemic maintenance anti-cytomegalovirus therapy treated with highly active antiretroviral therapy]
- Ophthalmologe. 1999 Dec;96(12):829-31. Unique Identifier : AIDSLINE MED/20107930
- Schaller UC; Walli RK; Mueller AJ; Klauss V; Universitats-Augenklinik Munchen.
- BACKGROUND: The purpose of this study was to evaluate the course of CMV retinitis after initiation of highly active antiretroviral therapy (HAART) and discontinuation of systemic anti-CMV maintenance therapy. PATIENTS AND METHODS: Case reports are presented for
- HIV infection of megakaryocytic cell lines.
- Leuk Lymphoma. 2000 Jan;36(3-4):397-404. Unique Identifier : AIDSLINE MED/20137377
- Sato T; Sekine H; Kakuda H; Miura N; Sunohara M; Fuse A; Department of Pediatrics, School of Medicine, Chiba University,; Japan.
- Thrombocytopenia is a common hematologic disorder in HIV infection and occurs in both asymptomatic and AIDS patients. An autoimmune mechanism has been postulated for the platelet destruction associated with some forms of thrombocytopenia. However, recent studies revealed that megakaryocytes are susceptible to HIV infe
- In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain.
- Neurochem Int. 2000 Mar;36(3):185-91. Unique Identifier : AIDSLINE MED/20140021
- Pocernich CB; La Fontaine M; Butterfield DA; Department of Chemistry, University of Kentucky, Lexington 40506,; USA.
- Glutathione deficiency has been associated with a number of neurodegenerative diseases including Lou Gehrig s disease, Parkinson s disease, and HIV. A crucial role for glutathione is as a free radical scavenger. Alzheimer s disease (AD) brain is characterized by oxidative stress, manifested by protein oxidation, lipid
- Protists as opportunistic pathogens: public health impact in the 1990s and beyond.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):15-20. Unique Identifier : AIDSLINE MED/20114712
- Kaplan JE; Jones JL; Dykewicz CA; Division of AIDS, STD and TB Laboratory Research, National Center; for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA. jxk2@cdc.gov
- Protist organisms (protozoa and fungi) have become increasingly prominent as opportunistic pathogens among persons infected with human immunodeficiency virus (HIV) and among organ transplant recipients--two immunocompromised populations that have increased dramatically in the past two decades. Pneumocystis carinii pne
- Clinical presentation and significance of emerging opportunistic infections.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):21-3. Unique Identifier : AIDSLINE MED/20114713
- Miller RF; Windeyer Institute of Medical Sciences, Royal Free and University; College Medical School, London, UK. rmiller@gum.ucl.ac.uk
- In recent years the clinical face of the Acquired Immune Deficiency Syndrome has changed significantly as a consequence of use of prophylaxis against Pneumocystis carinii pneumonia and combination antiretroviral therapy. In this context several opportunistic pathogens have emerged as causes of clinically important dis
- Penicillium marneffei: an insurgent species among the penicillia.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):24-8. Unique Identifier : AIDSLINE MED/20114714
- Cooper CR Jr; Haycocks NG; WHO Collaborating Center for Tropical Diseases, Department of; Pathology, University of Texas Medical Branch, Galveston; 77555-0609, USA. crcooper@utmb.edu
- Most species of Penicillium are considered relatively benign with respect to causing human disease. However, one species, P. marneffei, has emerged as a significant pathogen particularly among individuals who live in Southeast Asia and are concurrently infected with the human immunodeficiency virus. While environmenta
- The increasing importance of Acanthamoeba infections.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):29-36. Unique Identifier : AIDSLINE MED/20114715
- Marciano-Cabral F; Puffenbarger R; Cabral GA; Department of Microbiology & Immunology, Medical College of; Virginia of Virginia Commonwealth University, Richmond; 23298-0678, USA. ))). fmcabral@hsc.vcu.edu
- Free-living amebae belonging to the genus Acanthamoeba are the causative agents of granulomatous amebic encephalitis, a chronic progressive disease of the central nervous system, and of amebic keratitis, a chronic eye infection. Granulomatous amebic encephalitis occurs more frequently in immunocompromised patients whi
- Leishmania, Trypanosoma and monoxenous trypanosomatids as emerging opportunistic agents.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):37-9. Unique Identifier : AIDSLINE MED/20114716
- Dedet JP; Pratlong F; Laboratoire de Parasitologie, C.H.U. de Montpellier, 163, France.; parasito@sc.univ-montp1.fr
- Immunosuppression is associated with the occurrence of a large variety of infections, several of them due to opportunistic protozoa. The parasitic protozoa of the family Trypanosomatidae vary greatly in their importance as potential opportunistic pathogens. African trypanosomiasis is no more common nor severe during A
- The sensitivity and specificity of self-reported symptoms in individuals with traumatic brain injury.
- Brain Inj. 2000 Jan;14(1):21-33. Unique Identifier : AIDSLINE MED/20134119
- Gordon WA; Haddad L; Brown M; Hibbard MR; Sliwinski M; Department of Rehabilitation Medicine, Mount Sinai School of; Medicine, New York, NY 10029, USA. Wayne_Gordon@mssm.edu
- In this study, self-reported symptoms (cognitive, physical, behavioural/affective) from the TIRR Symptom Checklist are compared across six panels: 135 individuals with mild TBI, 275 with moderate/severe TBI, 287 with no disability, 104 with spinal cord injury, 197 who are HIV positive and 107 who had undergone liver t
- The unveiling of traumatic brain injury in an HIV/AIDS population.
- Brain Inj. 2000 Jan;14(1):35-44. Unique Identifier : AIDSLINE MED/20134120
- Jaffe MP; O'Neill J; Vandergoot D; Gordon WA; Small B; Center for Essential Management Services, NY, USA.
- This study examines the frequency of traumatic brain injury (TBI) in an HIV/AIDS population and its associated symptomatology. A panel of 173 individuals with HIV were split into two groups--those who have experienced a blow to the head within their lifetime (n = 128) and those who have not (n = 45). Self-reported sym
- [Drug-induced urinary calculi in 1999]
- Prog Urol. 1999 Dec;9(6):1023-33. Unique Identifier : AIDSLINE MED/20122707
- Daudon M; Laboratoire de Biochimie A, Hopital Necker-Enfants Malades,; Paris, France.
- Drug-induced urolithiasis are observed in 1.6% of the urinary calculi in France . Drugs crystals are identified in two thirds of these stones. Other drugs are responsible for stones which have an apparent metabolic origin (one third of the cases). Stone analysis using physical metho
- One-step capillary isoelectric focusing for the separation of the recombinant human immunodeficiency virus envelope glycoprotein glycoforms.
- J Chromatogr A. 2000 Jan 7;866(1):121-35. Unique Identifier : AIDSLINE MED/20143250
- Tran NT; Taverna M; Chevalier M; Ferrier D; Laboratoire de Chimie Analytique, Faculte de Pharmacie,; Chatenay-Malabry, France.
- One-step capillary isoelectric focusing was investigated as a rapid method to resolve the glycoforms of the heterogeneous recombinant human immunodeficiency virus (HIV) envelope glycoprotein (rgp 160sMN/LAI). The separation was performed in a poly(vinyl alcohol) (PVA) coated capillary using a mixture of ampholyte of n
- In vitro ethanol suppresses alveolar macrophage TNF-alpha during simian immunodeficiency virus infection.
- Am J Respir Crit Care Med. 2000 Jan;161(1):135-40. Unique Identifier : AIDSLINE MED/20087336
- Stoltz DA; Nelson S; Kolls JK; Zhang P; Bohm RP Jr; Murphey-Corb M; Bagby GJ; Department of Medicine, Section of Pulmonary/Critical Care,; Alcohol Research Center, New Orleans, Louisiana, USA.
- Pulmonary infections are a significant cause of morbidity and mortality in patients with alcohol abuse and human immunodeficiency virus (HIV) infection, two immunocompromising conditions that frequently coexist. This study examined the separate and combined effects of in vivo lentiviral infection and in vitro alcohol
- Reversal of human immunodeficiency virus type 1 protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):101-5. Unique Identifier : AIDSLINE MED/20087391
- Nair MP; Schwartz SA; Department of Medicine and Microbiology, Division of Allergy,; Immunology and Rheumatology, and Buffalo General Hospital, School; of Medicine and Biomedical Sciences, State University of New York; at Buffalo, New York 14203, USA. mnair@acsu.buffalo.edu
- A recombinant fusion peptide, Env-Gag, derived from the human immunodeficiency virus type 1 (HIV-1) genome corresponding to a defined portion of the envelope (Env) and internal core (Gag) proteins was examined for immunoregulatory effects on the cytotoxic activity of natural killer (NK) cell-enriched, large granular l
- Evaluation of the quantiplex human immunodeficiency virus type 1 RNA 3.0 assay in a tertiary-care center.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):122-4. Unique Identifier : AIDSLINE MED/20087396
- Gale H; Infectious Diseases Section, Medical Service, Veterans Affairs; Medical Center, Washington, D.C 20422, USA.; gale.howard@washington.va.gov
- The Quantiplex human immunodeficiency virus type 1 RNA 3.0 Assay (bDNA) (Bayer Diagnostics, Walpole, Mass.) produced linear and reproducible (intra-assay and interassay) results over its quantification range of 50 to 500,000 copies/ml of plasma with 96% specificity. A threefold or 0.5-log(10) change or greater was cli
- Development of positive selectable markers for the fungal pathogen Cryptococcus neoformans.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):125-8. Unique Identifier : AIDSLINE MED/20087397
- Hua J; Meyer JD; Lodge JK; Edward A. Doisy Department of Biochemistry and Molecular Biology,; St. Louis University School of Medicine, St. Louis, Missouri; 63104, USA.
- Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningitis in approximately 10% of patients with AIDS. New selectable markers which confer resistance to G418 or phleomycin when transformed into C. neoformans were made. A hygromycin-selectable marker was modified to allow selection with a single
- Diagnosis of human immunodeficiency virus infection using an immunoglobulin E-based assay.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):55-7. Unique Identifier : AIDSLINE MED/20087382
- Fletcher M; Miguez-Burbano MJ; Shor-Posner G; Lopez V; Lai H; Baum MK; Department of Medicine, University of Miami School of Medicine,; Miami, Florida.
- Immunoglobulin assays that are sensitive and specific for detecting human immunodeficiency virus type 1 (HIV-1) infection are especially important in developing countries where PCR and viral culture may not be readily available. Immunoglobulin E (IgE), which is elevated in HIV-1 infection, is the only antibody that do
- Validation of immune-complex enzyme immunoassays for diagnosis of pneumococcal pneumonia among adults in Kenya.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):64-7. Unique Identifier : AIDSLINE MED/20087384
- Scott JA; Hall AJ; Leinonen M; Centre for Geographic Medicine Research-Coast, Kenya Medical; Research Institute, Kilifi, Kenya. Ascott@kilifi.mimcom.net
- The efficacy of pneumococcal vaccines in protecting against pneumococcal pneumonia can feasibly be measured only with a diagnostic technique that has a high specificity (0.98 to 1.00) and a sensitivity greatly exceeding that of blood cultures (>0.2 to 0.3). In this context immune-complex enzyme immunoassays (EIAs) off
- Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):96-100. Unique Identifier : AIDSLINE MED/20087390
- Nair MP; Chadha KC; Hewitt RG; Mahajan S; Sweet A; Schwartz SA; State University of New York at Buffalo, Buffalo General; Hospital, Buffalo, New York 14203, USA. mnair@acsu.buffalo.edu
- Earlier studies have supported a significant role for cocaine in the susceptibility to and the progression of human immunodeficiency virus type 1 (HIV-1) infection. Recently, several unique HIV-1 entry coreceptors (e.g., CCR5 and CCR3) and a trio of HIV-1-specific suppressor chemokines, namely, RANTES (regulated-upon-
- Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.
- Immunity. 2000 Jan;12(1):27-37. Unique Identifier : AIDSLINE MED/20125019
- Ouyang W; Lohning M; Gao Z; Assenmacher M; Ranganath S; Radbruch A; Murphy KM; Department of Pathology and Center for Immunology, Howard Hughes; Medical Institute, Washington University School of Medicine, St.; Louis, Missouri 63110, USA.
- The initial source of IL-4-inducing Th2 development and the mechanism of stable Th2 commitment remain obscure. We found the reduced level of IL-4 production in Stat6-deficient T cells to be significantly higher than in Th1 controls. Using a novel cell surface affinity matrix technique, we found that IL-4-secreting Sta
- Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
- Immunity. 2000 Jan;12(1):61-70. Unique Identifier : AIDSLINE MED/20125022
- Kanazawa S; Okamoto T; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine,; University of California, San Francisco 94143, USA.
- AIDS and the bare lymphocyte syndrome (BLS) are severe combined immunodeficiencies. BLS results from mutations in genes that regulate the expression of class II major histocompatibility (MHC II) determinants. One of these is the class II transactivator (CIITA). HIV and its transcriptional transactivator (Tat) also blo
- Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.
- Immunity. 2000 Jan;12(1):83-93. Unique Identifier : AIDSLINE MED/20125024
- Chen W; Anton LC; Bennink JR; Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892-0440, USA.
- Following influenza virus infection, the numbers of mouse TCD8+ cells responding to five different determinants vary more than 50-fold in primary responses but less so in secondary responses. Surprisingly, each determinant elicits a highly diverse and highly sensitive TCD8+ response. Inefficient antigen processing by
- Immunogene therapy against mouse leukemia using B7 molecules.
- Cancer Gene Ther. 2000 Jan;7(1):144-50. Unique Identifier : AIDSLINE MED/20141835
- Takahashi T; Hirano N; Takahashi T; Chiba S; Yazaki Y; Hirai H; Third Department of Internal Medicine, Faculty of Medicine,; University of Tokyo, Japan.
- B7 costimulatory molecules play an important role in T-cell activation. It is well known that tumor cells that express B7 molecules can elicit antitumor immunity, but little is known regarding which B7 molecule, B7-1 (CD80) or B7-2 (CD86), can do so more efficiently. To address this issue, we have introduced B7-1 or B
- CXC and CC chemokine receptors on coronary and brain endothelia.
- Mol Med. 1999 Dec;5(12):795-805. Unique Identifier : AIDSLINE MED/20133089
- Berger O; Gan X; Gujuluva C; Burns AR; Sulur G; Stins M; Way D; Witte M; Weinand M; Said J; Kim KS; Taub D; Graves MC; Fiala M; Department of Neurology, UCLA School of Medicine, Los Angeles,; California 90095-1769, USA.
- BACKGROUND: Chemokine receptors on leukocytes play a key role in inflammation and HIV-1 infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue invasion and angiogenesis. MATERIALS AND METHODS: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC)
- Critical role of nitric oxide during the apoptosis of peripheral blood leukocytes from patients with AIDS.
- Unique Identifier : AIDSLINE MED/20133091
- Mossalayi MD; Becherel PA; Debre P
- BACKGROUND: Highly active antiretroviral therapies (HAART) increase the CD4(+) cell count, but complete normalization of this parameter has not been obtained in some patients. As oxidative stress plays an important role during human immunodeficiency virus type 1 (HIV-1)-associated deme
- Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome.
- RNA. 2000 Jan;6(1):96-102. Unique Identifier : AIDSLINE MED/20132236
- Takahashi KI; Baba S; Chattopadhyay P; Koyanagi Y; Yamamoto N; Takaku H; Kawai G; Department of Industrial Chemistry, Chiba Institute of; Technology, Japan.
- Generation of RNA dimeric form of the human immunodeficiency virus type 1 (HIV-1) genome is crucial for viral replication. The dimerization initiation site (DIS) has been identified as a primary sequence that can form a stem-loop structure with a self-complementary sequence in the loop and a bulge in the stem. It has
- Avascular necrosis of bone in human immunodeficiency virus infected patients.
- Clin Imaging. 1999 Sep-Oct;23(5):314-8. Unique Identifier : AIDSLINE MED/20128735
- Blacksin MF; Kloser PC; Simon J; Department of Radiology, University of Medicine & Dentistry of; New Jersey, C-320 University Hospital, Newark 07103-2426, USA.
- The objective of this article was to delineate the causes of avascular necrosis (AVN) in patients with human immunodeficiency virus (HIV). HIV-infected patients with pain in large joints were prospectively screened. Patients had radiographs and magnetic resonance imaging of their affected joints. Serum lipids, anticar
- A patient with an acute viral syndrome.
- Tenn Med. 2000 Feb;93(2):64-5. Unique Identifier : AIDSLINE MED/20133550
- Aronoff DM; Morgan HJ; Vanderbilt University Medical Center, Nashville, USA.
- CPHA and the global effort to strengthen responses to HIV/AIDS [news]
- Can J Public Health. 1999 Nov-Dec;90(6):364. Unique Identifier : AIDSLINE MED/20144507
- Dafoe GH
- Fas-resistance in ATL cell lines not associated with HTLV-I or FAP-1 production.
- Cancer Lett. 1999 Dec 1;147(1-2):215-9. Unique Identifier : AIDSLINE MED/20123505
- Yamada Y; Sugahara K; Tsuruda K; Nohda K; Hata T; Maeda T; Honda M; Tawara M; Hayashibara T; Joh T; Tomonaga M; Miyazaki Y; Kamihira S; Department of Laboratory Medicine, Nagasaki University School of; Medicine, Japan.
- A preventive role for human T-cell leukemia virus type-I (HTLV-I) and Fas-associated phosphatase-1 (FAP-1) in Fas-mediated apoptosis has been reported in HTLV-I-infected cells. In the present study, we examined whether these molecules increased during the acquisition of Fas-resistance in adult T-cell leukemia (ATL) ce
- Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo.
- Cancer Res. 2000 Jan 15;60(2):253-8. Unique Identifier : AIDSLINE MED/20129032
- Bronte V; Apolloni E; Ronca R; Zamboni P; Overwijk WW; Surman DR; Restifo NP; Zanovello P; Department of Oncology and Surgical Sciences, University of; Padova, Italy. vbronte@ux1.unipd.it
- Self melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet
- Cytokine replacement in patients with HIV-1 non-Hodgkin's lymphoma: the rationale for low-dose interleukin-2 therapy.
- Cancer J Sci Am. 2000 Feb;6 Suppl 1:S45-51. Unique Identifier : AIDSLINE MED/20148094
- Shah MH; Baiocchi RA; Fehniger TA; Khatri VP; Gould M; Poiesz B; Bernstein ZP; Caligiuri MA; Division of Hematology/Oncology, The Arthur G. James Cancer; Hospital and Solove Research Institute, Columbus, Ohio, USA.
- PURPOSE: The drastic increase in the incidence of non-Hodgkin s lymphoma in patients infected with HIV-1 is testimony to the fact that our immune system is critical for the prevention of certain malignancies. Preclinical and clinical studies were conducted to (1) gain further insig
- The future of interleukin-2: enhancing therapeutic anticancer vaccines.
- Cancer J Sci Am. 2000 Feb;6 Suppl 1:S76-80. Unique Identifier : AIDSLINE MED/20148100
- Overwijk WW; Theoret MR; Restifo NP; Surgery Branch, National Cancer Institute, National Institutes of; Health, Bethesda, Maryland 20892-1502, USA.
- PURPOSE: The purpose of our efforts is to trigger the immune destruction of established cancer. Interleukin (IL)-2 can mediate the regression of tumors in patients with melanoma and renal cell carcinoma. In animal models, the antitumor effects of IL-2 are mediated by T
- [Use of plasmapheresis in patients with AIDS and peripheral polyneuropathy]
- Pol Merkuriusz Lek. 1999 Nov;7(41):215-7. Unique Identifier : AIDSLINE MED/20144705
- Lapinski TW; Prokopowicz D; Kliniki Obserwacyjno- Zakaznej Akademii Medycznej w Bialymstoku.
- The plasmapheresis is procedure removal of plasma and simultaneously, together with plasma, toxins, incorrect metabolites, antigens and immunological complexes. In patients with HIV infection often appearance periphery polyneuropathy. This is connected with autoantibody action on the damage of neurone. The aim of this
- The art of molecular graphics. The 1998 Molecular Graphics Art Show.
- J Mol Graph Model. 1999 Feb;17(1):55-6. Unique Identifier : AIDSLINE MED/20126747
- Goodsell DS; Scripps Research Institute, Department of Molecular Biology, La; Jolla, CA 92037, USA. goodsell@scripps.edu
- HIV testing of patients: let's waive the waiver.
- CMAJ. 2000 Jan 25;162(2):210-1. Unique Identifier : AIDSLINE MED/20139011
- Tyndall MW; Schechter MT; Department of Health Care and Epidemiology, Faculty of Medicine,; University of British Columbia, Vancouver.; martin.schechter@ubc.ca
- Determination of nelfinavir, a potent HIV protease inhibitor, and its active metabolite M8 in human plasma by high-performance liquid chromatography with photodiode-array detection.
- J Chromatogr B Biomed Sci Appl. 1999 Dec 10;735(2):159-70. Unique Identifier : AIDSLINE MED/20134192
- Lamotte C; Peytavin G; Farinotti R; Service de Pharmacie Clinique et des Biomateriaux, Groupe; Hospitalier X.Bichat-C.Bernard, Paris, France.
- We developed and characterized a high-performance liquid chromatographic assay for the determination of nelfinavir (NFV), a potent HIV protease inhibitor, and its active metabolite M8 in human plasma. Extraction of the internal standard, M8 and NFV from the plasma buffered at pH 9.5 was achieved by a liquid-liquid ext
- Expression, purification and biological properties of the carboxyl half part of the HTLV-I surface envelope glycoprotein.
- J Chromatogr B Biomed Sci Appl. 2000 Jan 14;737(1-2):85-95. Unique Identifier : AIDSLINE MED/20143280
- Tallet B; Astier-Gin T; Londos-Gagliardi D; Guillemain B; EP630 CNRS-Universite Victor Segalen Bordeaux 2, France.
- The carboxyl half of the surface envelope protein of HTLV-I contains the major immunodominant and neutralizable domains. Using two affinity chromatography steps and a combination of high salt concentration and non-ionic detergent, we purified this part of the envelope protein from Escherichia coli. Analysis of some im
- Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.
- Clin Cancer Res. 2000 Jan;6(1):102-11. Unique Identifier : AIDSLINE MED/20120231
- Rempel SA; Dudas S; Ge S; Gutierrez JA; Henry Ford Midwest Neuro-Oncology Center, Department of; Neurosurgery, Henry Ford Health Sciences Center, Detroit,; Michigan 48202, USA. nssan@neuro.hfh.edu
- Glioblastoma multiforme (GBM) tumors display extensive histomorphological heterogeneity, with great variability in the extent of invasiveness, angiogenesis, and necrosis. The identification of genes associated with these phenotypes should further the molecular characterization, permitting better definition of glioma s
- Behavioral-diagnostic analysis of compliance with universal precautions among nurses.
- J Occup Health Psychol. 2000 Jan;5(1):127-41. Unique Identifier : AIDSLINE MED/20122001
- DeJoy DM; Searcy CA; Murphy LR; Gershon RR; Department of Health Promotion and Behavior, University of; Georgia, Athens 30602-6522, USA. ddejoy@coe.uga.edu
- This study used the PRECEDE model (L.W. Green, M.W. Kreuter, S.G. Deeds, & K.B. Partridge, 1980) to examine individual, job-task, and environmental-organizational factors related to compliance with universal precautions (UP) among nurses. Structural equation modeling showed that the hypothesized model did a better
- Nutrients and HIV: part one -- beta carotene and selenium.
- Altern Med Rev. 1999 Dec;4(6):403-13. Unique Identifier : AIDSLINE MED/20076811
- Patrick L
- Micronutrient deficiencies are common in HIV/AIDS, resulting from both malabsorption and virally-caused depletion. Beta carotene and selenium deficiencies, two of the most common nutrient deficiencies, are important due to their dual function as nutrients necessary for immune modulation and as antioxidants. Beta carot
- Acetyl-L-carnitine.
- Altern Med Rev. 1999 Dec;4(6):438-41. Unique Identifier : AIDSLINE MED/20076816
- Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and st
- Chemical process evolution of efavirenz, a potent non-nucleosidal HIV reverse transcriptase inhibitor.
- Enantiomer. 1999;4(6):599-608. Unique Identifier : AIDSLINE MED/20136402
- Chen CY; Tan L; Department of Process Research, Merck Research Laboratories,; Rahway, NJ 07065, USA. cheng_chen@merck.com
- Highly loaded nanoparticulate carrier using an hydrophobic antisense oligonucleotide complex.
- Eur J Pharm Sci. 1999 Dec;9(2):163-70. Unique Identifier : AIDSLINE MED/20089035
- Berton M; Allemann E; Stein CA; Gurny R; School of Pharmacy, University of Geneva, quai E.-Ansermet; CH-1211, Geneva, Switzerland.
- Antisense oligonucleotides, and particularly those with phosphorothioate backbones, have emerged as potential gene specific therapeutic agents and are currently undergoing evaluation in clinical trials for a variety of diseases. In the area of HIV-1 therapeutics, targeting of oligonucleotides to infected cells, such a
- Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity.
- Bioorg Med Chem Lett. 2000 Jan 3;10(1):87-90. Unique Identifier : AIDSLINE MED/20100206
- Dong Y; Venkatachalam TK; Narla RK; Trieu VN; Sudbeck EA; Uckun FM; Drug Discovery Program, Department of Chemistry, Hughes; Institute, St Paul, MN 55113, USA.
- In a systematic search for novel dual function antioxidants with potent anti-HIV activity, we evaluated 9 rationally designed non-nucleoside inhibitors (NNI) of HIV-1 RT for antioxidant and anti-HIV activities. Our lead phenethyl-5-bromopyridyl thiourea (PEPT) compounds, N-[2-(2-methoxyphenylethyl)]-N -[2-(5-bromopyri
- 5' Nuclease assays for the loci CCR5-+/Delta32, CCR2-V64I, and SDF1-G801A related to pathogenesis of AIDS.
- Clin Chem. 2000 Jan;46(1):24-30. Unique Identifier : AIDSLINE MED/20088722
- Yuan CC; Peterson RJ; Wang CD; Goodsaid F; Waters DJ; Laboratory of Genomic Diversity, National Cancer; Institute-Frederick Cancer Research and Development Center,; Frederick, MD 21702, USA.
- BACKGROUND: Variations within the human genome play important roles in human disease. To study variations related to susceptibility to AIDS, we have developed 5 nuclease assays that eliminate post-PCR molecular biology steps. METHODS: TaqMan assays based on the 5 nuclease activity of Taq polymerase and fluorescent r
- Simultaneous HPLC assay for quantification of indinavir, nelfinavir, ritonavir, and saquinavir in human plasma.
- Clin Chem. 2000 Jan;46(1):73-81. Unique Identifier : AIDSLINE MED/20088728
- Remmel RP; Kawle SP; Weller D; Fletcher CV; Departments of Medicinal Chemistry and Experimental and Clinical; Pharmacology, College of Pharmacy, University of Minnesota,; Minneapolis, MN 55455, USA. remme001@tc.umn.edu
- BACKGROUND: HIV protease inhibitors are recommended as part of combination antiretroviral therapy. Dual protease inhibitor therapy is also being used clinically. Consequently, a simultaneous assay for indinavir, nelfinavir,
- Clinical significance of serum soluble IL-2R levels in patients with adult T cell leukaemia (ATL) and HTLV-1 carriers.
- Clin Exp Immunol. 2000 Feb;119(2):259-63. Unique Identifier : AIDSLINE MED/20098463
- Araki K; Harada K; Nakamoto K; Shiroma M; Miyakuni T; Department of Medical Technology, School of Health Science,; Faculty of Medicine, University of the Ryukyu, Japan.; karaki@med.u-ryukyu.ac.jp
- The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the
- Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro.
- Clin Exp Immunol. 2000 Feb;119(2):299-304. Unique Identifier : AIDSLINE MED/20098469
- Brodskyn C; Beverley SM; Titus RG; Laboratorio de Imunologia, Departamento de Biointeracao,; Instituto de Ciencias da Saude, Universidade Federal da Bahia,; Bahia, Brazil.
- In this study we have compared the immune response of normal human cells cultured in vitro to two virulent strains of Leishmania major (CC1 and LV39), and to an avirulent vaccine strain (dhfr-ts-) made by targeted deletion of the essential gene DHFR-TS. We utilized an in vitro system in which naive T cells from normal
- Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response.
- Clin Exp Immunol. 2000 Feb;119(2):354-60. Unique Identifier : AIDSLINE MED/20098478
- Saegusa K; Ishimaru N; Yanagi K; Haneji N; Nishino M; Azuma M; Saito I; Hayashi Y; Department of Pathology, Tokushima University School of; Dentistry, Tokushima, Japan.
- Intraperitoneal administration with anti-CD86 (B7.2) MoAb into the murine model for primary SS in NFS/sld mutant mice resulted in dramatically inhibitory effects on the development of autoimmune lesions, while no significant effects were observed when the mice were administered with anti-CD80 (B7.1) MoAb. We found tha
- Finding a role for zalcitabine in the HAART era.
- Antivir Ther. 1998;3(3):125-37. Unique Identifier : AIDSLINE MED/20146711
- Moyle GJ; Gazzard BG; Kobler Clinic, Chelsea and Westminster Hospital, London, UK.
- Zalcitabine ( ddC ) is a nucleoside analogue reverse transcriptase inhibitor with demonstrated clinical benefit in combination use. More widespread use of zalcitabine has been limited by a number of factors including
- Meta-analysis of antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death.
- Antivir Ther. 1998;3(3):139-45. Unique Identifier : AIDSLINE MED/20146712
- Hill AM; DeMasi R; Dawson D; GlaxoWellcome, Greenford, Middlesex, UK. AMH21137@GGR.CO.UK
- There is uncertainty as to how the effects of antiretroviral treatments on human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4 cell counts can predict reductions in clinical progression to AIDS or death. A meta-analysis was conducted for 27 pairwise comparisons of antiretroviral treatments in 15 randomized
- Management of antiretroviral therapy for HIV infection: modelling when to change therapy.
- Antivir Ther. 1998;3(3):147-58. Unique Identifier : AIDSLINE MED/20146713
- D'Amato RM; D'Aquila RT; Wein LM; Operations Research Center, Massachusetts Institute of; Technology, Cambridge 02139, USA.
- OBJECTIVE: To evaluate four strategies for monitoring plasma HIV RNA levels and/or resistance genotypes to decide when to change antiretroviral therapy. The strategies include: (i) 1997 guidelines recommending a therapy switch when plasma RNA exceeds a threshold level; (ii) a viral load policy, using a fixed increase
- Improvement in immune function due to treatment with indinavir despite severe immune deficiency.
- Unique Identifier : AIDSLINE MED/20146714
- Rothen M; Bisset LR; Joller-Jemelka HI; Grob P; Luthy R; Opravil M; Division of Infectious Diseases and Hospital Epidemiology,; University Hospital Zurich, Switzerland.
- To study the virological, immunological and clinical effects of the protease inhibitor indinavir in human immunodeficiency virus (HIV)-infected patients with CD4 counts
- Prediction of HIV-1 RNA suppression and its durability during treatment with zidovudine/lamivudine.
- Unique Identifier : AIDSLINE MED/20146715
- Opravil M; Hill AM; DeMasi R; Dawson D
- To predict the probability of long-term viral suppression during treatment with zidovudine and lamivudine, human immunodeficiency virus type 1 (HIV-1) RNA values were retrospectively pooled for 1083 patients from six randomized, double-blind clinical trials. All analyses of HIV-1 RNA were obtained using the Roche Ampl
- Diminished HIV-1 sensitivity to stavudine in patients on prolonged therapy occurs only at low levels and cannot be attributed to any single amino acid substitution in reverse transcriptase.
- Antivir Ther. 1998;3(3):177-82. Unique Identifier : AIDSLINE MED/20146716
- Salomon H; Montaner JS; Belmonte A; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.
- To study the extent to which phenotypic resistance to stavudine occurs under therapy, we studied 18 pairs of human immunodeficiency virus type 1 (HIV-1) isolates from patients both prior to and following 24-48 weeks of treatment with stavudine monothe
- Genotypic and phenotypic resistance to stavudine after long-term monotherapy. BMS-020 Spanish Study Group.
- Antivir Ther. 1998;3(3):183-6. Unique Identifier : AIDSLINE MED/20146717
- Holguin A; Dietrich U; Immelmann A; Soriano V; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
- Protocol BMS 020 was a double-blind, prospective clinical trial in which two different doses of stavudine (20 and 40 mg twice daily) were compared in human immunodeficiency virus (HIV)-infected patients with previous exposure to zidovudine for longer
- Quantitative p24 antigenaemia for monitoring response to antiretroviral therapy in HIV-1 group O-infected patients.
- Antivir Ther. 1998;3(3):187-9. Unique Identifier : AIDSLINE MED/20146718
- Machuca A; Gutierrez M; Mur A; Soriano V; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
- Failure to recognize infection caused by human immunodeficiency virus type 1 (HIV-1) group O variants has been described using both serological and genetic techniques. Moreover, the monitoring of response to antiretroviral therapy is difficult in persons carrying this infection since most currently available tests for
- Anti-HIV antiviral activity of stavudine in a thymidine kinase-deficient cellular line.
- Antivir Ther. 1998;3(3):191-4. Unique Identifier : AIDSLINE MED/20146719
- Turriziani O; Simeoni E; Dianzani F; Antonelli G; Institute of Virology, University La Sapienza, Rome, Italy.; virosap@flashnet.it
- Stavudine ( d4T ) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. It is known that stavudine is metabolized in cells to the mono-, di- and tr
- Loss of lamivudine resistance in a zidovudine and lamivudine dual-resistant HIV-1 isolate after discontinuation of in vitro lamivudine drug pressure.
- Antivir Ther. 1998;3(4):203-7. Unique Identifier : AIDSLINE MED/20146720
- Rusconi S; De Pasquale MP; Milazzo L; Kurtagic S; Bulgheroni E; Citterio P; Galazzi M; La Seta Catamancio S; Galli M; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Italy. rusconi@imiucca.csi.unimi.it
- We examined the in vitro phenotypic and genotypic profiles of an extensively passaged human immunodeficiency virus type 1 clinical isolate which has been selected for lamivudine resistance, with an M184V mutation in a zidovudine-resistant genetic background, and then cultured with zidovudine alone. Our passaging strat
- Kinetics of productive and latent HIV infection in lymphatic tissue and peripheral blood during triple-drug combination therapy with or without additional interleukin-2.
- Antivir Ther. 1998;3(4):209-14. Unique Identifier : AIDSLINE MED/20146721
- Stellbrink HJ; Hufert FT; Tenner-Racz K; Lauer J; Schneider C; Albrecht H; Racz P; van Lunzen J; Medical Department, University Hospital Eppendorf, Hamburg,; Germany. stellbri@uke.uni-hamburg.de
- OBJECTIVE: To study decay rates of productively and latently infected cells in peripheral blood and lymph nodes during triple antiretroviral therapy and the possible impact of interleukin-2 ( IL-2 ) on viral kinetics. METHODS: In this non-randomized study, nine antiretro
- Low plasma concentrations of indinavir are related to virological treatment failure in HIV-1-infected patients on indinavir-containing triple therapy.
- Antivir Ther. 1998;3(4):215-20. Unique Identifier : AIDSLINE MED/20146722
- Burger DM; Hoetelmans RM; Hugen PW; Mulder JW; Meenhorst PL; Koopmans PP; Brinkman K; Keuter M; Dolmans W; Hekster YA; Department of Clinical Pharmacy, University Hospital Nijmegen,; The Netherlands. D.Burger@klinfarm.azn.nl
- All human immunodeficiency virus type 1 (HIV-1)-infected patients who started to use indinavir (800 mg three times a day) as part of their triple drug regimen were included in a study to determine the importance of low plasma concentrations of indinav
- Evaluation of mixtures of wild-type HIV-1 and HIV-1 with resistance point mutations against reverse transcriptase inhibitors.
- Antivir Ther. 1998;3(4):221-7. Unique Identifier : AIDSLINE MED/20146723
- Villahermosa ML; Contreras G; Perez-Alvarez L; Bru F; Medrano L; Delgado E; Colomo C; Thomson M; Najera R; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, Madrid, Spain.
- The presence of resistance-related mutations in 185 serial proviral DNA samples from 108 HIV-infected patients was monitored using the line probe assay (LiPA). The proportions of wild-type and mutant virus in each sample were determined. Subsequent samples from the same patient were analysed. Resistance mutations were
- Opportunistic infections shortly after beginning highly active antiretroviral therapy.
- Antivir Ther. 1998;3(4):229-31. Unique Identifier : AIDSLINE MED/20146724
- Rodriguez-Rosado R; Soriano V; Dona C; Gonzalez-Lahoz J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; SaludCarlos III, Madrid, Spain. rafael.rodriguez@mad.servicom.es
- The clinical benefit of highly active antiretroviral therapy (HAART) has been attributed to its suppression of viral replication and improvement in the CD4 lymphocyte count. However, the development of clinical symptoms secondary to previously silent opportunistic pathogens shortly after beginning HAART has been repor
- Combination treatment for hepatitis C can be hazardous in patients co-infected with HIV [letter]
- Unique Identifier : AIDSLINE MED/20146725
- Schvarcz R; Moberg L; Sonnerborg A
- Hepatitis B virus antiviral drug resistance: from the laboratory to the patient.
- Antivir Ther. 1998;3(4):243-6. Unique Identifier : AIDSLINE MED/20146728
- Mutimer D; Liver & Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham,; UK. david.mutimer@university-b.wmids.nhs.uk
- The development and application of nucleoside (and nucleotide) analogues for the treatment of chronic hepatitis B infection will transform the management of this condition. For instance, treatment with lamivudine effects a dramatic and measurable reduction of serum virus titre. This is associated with biochemical and
- Laboratory markers of antiviral activity.
- Antivir Ther. 1998;3(4):247-50. Unique Identifier : AIDSLINE MED/20146729
- Christopherson C; Lu SD; Kwok S; Roche Molecular Systems, Alameda, CA 94501, USA.
- Quantitative assays for viral nucleic acids have been instrumental in monitoring the response of patients to various antiviral therapies. The level of viraemia is predictive of clinical outcome in that a reduced risk of progression to AIDS or death was observed with lower plasma human immunodeficiency virus (HIV) RNA
- Stavudine resistance: an update on susceptibility following prolonged therapy.
- Unique Identifier : AIDSLINE MED/20146706
- Lin PF; Gonzalez CJ; Griffith B; Friedland G; Calvez V; Ferchal F; Schinazi RF; Shepp DH; Ashraf AB; Wainberg MA; Soriano V; Mellors JW; Colonno RJ; Bristol-Myers Squibb, Wallingford, Conn., USA. linp@bms.com
- The current report summarizes the available published and unpublished data from several investigators on resistance in clinical isolates following prolonged stavudine therapy. Results suggest that stavudine resistance is both modest in degree and infr
- Induction and maintenance treatment regimens for HIV-1 infection in vitro.
- Antivir Ther. 1999;4(1):29-34. Unique Identifier : AIDSLINE MED/20146707
- Oh MD; Merrill DP; Hirsch MS; Department of Medicine, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA.
- Can aggressive anti-human immunodeficiency virus (HIV) induction regimens be simplified after sufficient virus suppression is achieved? In vitro studies were conducted to evaluate the hypothesis that aggressive induction regimens could be followed by less aggressive maintenance regimens. A clinical HIV-1 isolate and l
- Quality of life outcomes of saquinavir, zalcitabine and combination saquinavir plus zalcitabine therapy for adults with advanced HIV infection with CD4 counts between 50 and 300 cells/mm3.
- Antivir Ther. 1999;4(1):35-44. Unique Identifier : AIDSLINE MED/20146708
- Revicki DA; Swartz C; Wu AW; Haubrich R; Collier AC; MEDTAP International Inc., Bethesda, Md., USA. revicki@medtap.com
- BACKGROUND: Benefits in patient health-related quality of life (HRQL) have not yet been demonstrated for combination antiretroviral therapy with protease inhibitors and nucleoside analogues. This double-blind study evaluated zalcitabine or saquinavir monotherapy and
- Presence of genotypic resistance in nucleoside analogue-treated HIV-1-infected patients with undetectable viral load.
- Antivir Ther. 1999;4(1):45-9. Unique Identifier : AIDSLINE MED/20146709
- Rubio A; Gomez-Cano M; Puig T; Leal M; Perez-Olmeda M; Ruiz L; Clotet B; Rey C; Zamora L; Xaus N; Soriano V; Department of Biochemistry, Virgen del Rocio University Hospital,; Seville, Spain.
- Patients harbouring drug-resistance viruses usually suffer a rise in serum viraemia after a variable period of time. We have investigated the relationship between the appearance of resistant genotypes and the viral load of each patient after treatment. Our objective was to assess the association between human immunode
- Retroviruses et opportunistic infections '99 [editorial]
- Antivir Ther. 1999;4(1):5-6. Unique Identifier : AIDSLINE MED/20146703
- Lange JM; Richman DD
- Acute hypersensitivity with delavirdine [letter]
- Antivir Ther. 1999;4(1):51. Unique Identifier : AIDSLINE MED/20146710
- Mills G; Morgan J; Hales G; Smith D
- Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation.
- Antivir Ther. 1999;4(1):7-14. Unique Identifier : AIDSLINE MED/20146704
- Cane PA; Mutimer D; Ratcliffe D; Cook P; Beards G; Elias E; Pillay D; PHLS Antiviral Susceptibility Reference Unit, University of; Birmingham Medical School, UK. p.cane@bham.ac.uk
- This report describes nucleotide sequence analysis of part of the polymerase gene of hepatitis B virus (HBV) during the development of lamivudine-resistant HBV in five patients who received lamivudine treatment in conjunction with liver transplantation. Samples from patients were analysed before, during and after drug
- Effect of weekly adefovir (PMEA) infusions on HIV-1 virus load: results of a phase I/II study.
- Antivir Ther. 1999;4(2):101-7. Unique Identifier : AIDSLINE MED/20146736
- Kamp W; Schokker J; Cambridge E; De Jong S; Schuurman R; De Groot T; Boucher CA; Fight for Life Foundation, Amsterdam, The Netherlands.
- The compound 9-(2-phosphonylmethoxyethyl)adenine (adefovir; PMEA) is a potent inhibitor of a number of viruses in vitro, such as human immunodeficiency virus (HIV) type 1 and 2, herpes simplex virus (HSV) type 1 and 2, human papillomavirus virus (HBV) and Epstein-Barr virus (EBV). Adefovir also proved to be effective
- Kinetics of beta-chemokine levels during anti-HIV therapy.
- Antivir Ther. 1999;4(2):109-15. Unique Identifier : AIDSLINE MED/20146737
- Aleman S; Pehrson P; Sonnerborg A; Division of Clinical Virology, Karolinska Institutet, Huddinge; University Hospital, Sweden. soki@labd01.hs.sll.se
- Chemokines are pro-inflammatory cytokines that inhibit human immunodeficiency virus type 1 (HIV-1) replication in vitro. We studied the kinetics of the beta-chemokines, macrophage inhibitory protein (MIP)-1 alpha, MIP-1 beta, RANTES, and monocyte chemotactic protein (MCP)-1 in plasma during 12 months of antiretroviral
- Patients failing saquinavir therapy require an early change to indinavir before HIV-1 viral load reaches high levels.
- Antivir Ther. 1999;4(2):117-21. Unique Identifier : AIDSLINE MED/20146738
- Dronda F; Perez-Elias MJ; Antela A; Casado JL; Marti-Belda P; Cobo J; Unidad de Enfermedades Infecciosas, Hospital Ramon y Cajal,; Universidad de Alcala, Madrid, Spain. fdronda@hrc.insalud.es
- Sequential use of antiretroviral therapy with protease inhibitors (PI) is frequently prescribed owing to failure or intolerance of the first selected agent. Controversial data exist about the virological and immunological outcome of patients in whom a change to a se
- Efficiency of drug resistance genotypic tests in specimens with low HIV viral load.
- Antivir Ther. 1999;4(2):123-4. Unique Identifier : AIDSLINE MED/20146739
- Gomez-Cano M; Rubio A; Ruiz L; Perez-Olmeda M; Leal M; Clotet B; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- The early recognition of resistance to antiretroviral agents could allow a rapid switch in therapy and therefore avoid the accumulation of mutations and reduce the risk of cross-resistance. However, the efficiency of genotypic tests in specimens with low viral load (VL) is severely compromised since human immunodefici
- Different outcome in the first two patients with an HIV-1 multinucleoside drug-resistant T69SSS insertion in Spain.
- Antivir Ther. 1999;4(2):125-7. Unique Identifier : AIDSLINE MED/20146740
- Briones C; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- A novel multidrug-resistance mechanism has been described in human immunodeficiency virus type 1 (HIV-1), which involves the insertion of 6 bp between codons 69 and 70 in the reverse transcriptase (RT) gene. Herein, we report the first two patients in Spain carrying viral population
- Effective salvage therapy for HIV-1 infection--an unmet challenge [editorial]
- Antivir Ther. 1999;4(2):59-60. Unique Identifier : AIDSLINE MED/20146730
- Montaner JS; Mellors JW
- Zidovudine resensitization and dual HIV-1 resistance to zidovudine and lamivudine in the delta lamivudine roll-over study.
- Antivir Ther. 1999;4(2):69-77. Unique Identifier : AIDSLINE MED/20146732
- Masquelier B; Descamps D; Carriere I; Ferchal F; Collin G; Denayrolles M; Ruffault A; Chanzy B; Izopet J; Buffet-Janvresse C; Schmitt MP; Race E; Fleury HJ; Aboulker JP; Yeni P; Brun-Vezinet F; Laboratoire de Virologie, University Hospital of Bordeaux,; France. bernard.masquelier@viro.u-bordeaux2.fr
- OBJECTIVE: To study zidovudine resensitization and dual resistance to zidovudine/lamivudine in HIV-1 isolates from nucleoside reverse transcriptase (RT) inhibitor-experienced patients during selective pressure exerted by zidovudine/lamivudine combination therapy . DESIG
- AVANTI 1: randomized, double-blind trial to evaluate the efficacy and safety of zidovudine plus lamivudine versus zidovudine plus lamivudine plus loviride in HIV-infected antiretroviral-naive patients. AVANTI Study Group.
- Antivir Ther. 1999;4(2):79-86. Unique Identifier : AIDSLINE MED/20146733
- Gatell J; Lange J; Gartland M; Glaxo Wellcome Research and Development, Middlesex, UK.
- The objective of this randomized double-blind, placebo-controlled trial was to investigate the effect of combination antiretroviral therapy on plasma HIV-1 RNA as measured by HIV RNA PCR and to assess the safety and tolerability of such regimens. The trial was carried out in seven European countries,
- In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA.
- Antivir Ther. 1999;4(2):87-94. Unique Identifier : AIDSLINE MED/20146734
- Wainberg MA; Miller MD; Quan Y; Salomon H; Mulato AS; Lamy PD; Margot NA; Anton KE; Cherrington JM; McGill University AIDS Center, Jewish General Hospital, Montreal,; Quebec, Canada.
- 9-(2-phosphonomethoxypropyl)adenine (PMPA) has demonstrated remarkable anti-simian immunodeficiency virus (SIV) activity in macaque models of SIV infection and transmission prevention. Recently, PMPA and its oral prodrug, bis-POC PMPA, have also shown potent anti-human immunodeficiency virus type 1 (HIV-1) activity in
- A combination of nucleoside analogues and a protease inhibitor reduces HIV-1 RNA levels in semen: implications for sexual transmission of HIV infection.
- Antivir Ther. 1999;4(2):95-9. Unique Identifier : AIDSLINE MED/20146735
- Liuzzi G; Chirianni A; Bagnarelli P; Clementi M; Piazza M; Istituto Malattie Infettive, Universita di Napoli Federico II,; Naples, Italy.
- Direct contact with semen is the major route of sexual acquisition of human immunodeficiency virus (HIV) in homosexual and heterosexual partners of seropositive men. In this study, we show that concentrations of HIV-1 RNA molecules in plasma and semen of seropositive patients are related to the duration and type of an
- Acetylcysteine. Fluimucil, Mucomyst, N-acetylcysteine, NAC, NSC 111180.
- Drugs R D. 1999 Oct;2(4):265-6. Unique Identifier : AIDSLINE MED/20124631
- Aldesleukin. Interleukin-2 (IL-2), IL-2 (Chiron), Macrolin, Proleukin, recombinant IL-2 (Chiron), T cell growth factor.
- Drugs R D. 1999 Oct;2(4):267-70. Unique Identifier : AIDSLINE MED/20124632
- Interferon-alpha-n3. Alferon, Alferon LDO, Alferon N, Alferon N Gel, Altemol, natural alpha interferon, alpha-n3-IF.
- Drugs R D. 1999 Oct;2(4):271-3. Unique Identifier : AIDSLINE MED/20124633
- Microvolume fluorimetry for the determination of absolute CD4 and CD8 lymphocyte counts in patients with HIV: a comparative evaluation.
- Clin Lab Haematol. 1999 Dec;21(6):391-5. Unique Identifier : AIDSLINE MED/20138634
- Glencross D; Scott L; Aggett H; Sonday S; Scott CS; Department of Haematology, South African Institute for Medical; Research, Johannesburg Hospital, Johannesburg, South Africa.
- This study compared CD4 and CD8 lymphocyte counts obtained by microvolume fluorimetry (MVF) with those derived by flow cytometry (FC). Samples from 192 patients with known or suspected HIV were analysed, and the distribution of CD4 counts for these samples ranged from 0 and 1,279/microl, with 142/192 (74%) of the samp
- Association of HLA-DQ and -DR alleles with protection from or infection with HIV-1.
- Exp Mol Pathol. 2000 Feb;68(1):21-8. Unique Identifier : AIDSLINE MED/20108856
- Roe DL; Lewis RE; Cruse JM; Department of Pathology, University of Mississippi Medical; Center, Jackson, Mississippi, 39216, USA.
- Infection with human immunodeficiency virus type 1 (HIV-1) and progression to acquired immune deficiency syndrome (AIDS) are controlled by both host genetic factors and viral factors. The HLA (human leukocyte antigen) region in humans controls immune response functions and tissue rejection and influences susceptibilit
- Granulomatous Pneumocystis carinii pneumonia in Wegener's granulomatosis.
- Eur Respir J. 2000 Jan;15(1):213-6. Unique Identifier : AIDSLINE MED/20142117
- Ullmer E; Mayr M; Binet I; Ebnother-Staub C; Dalquen P; Soler M; Tamm M; Division of Pneumology, University Hospital Basel, Switzerland.
- This study reports on a first case of granulomatous Pneumocystis carinii pneumonia (PCP) in a human immunodeficiency virus-negative patient with antineutrophil cytoplasmic antibody-positive Wegener s granulomatosis whilst receiving immunosuppressive treatment. The patient presented with diffuse alveolar haemorrhage, p
- Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society.
- Eur Respir J. 2000 Jan;15(1):217-31. Unique Identifier : AIDSLINE MED/20142118
- de Blic J; Midulla F; Barbato A; Clement A; Dab I; Eber E; Green C; Grigg J; Kotecha S; Kurland G; Pohunek P; Ratjen F; Rossi G
- A disulfide conjugate between anti-tetanus antibodies and HIV (37-72)Tat neutralizes tetanus toxin inside chromaffin cells.
- FEBS Lett. 1999 Sep 24;458(3):383-6. Unique Identifier : AIDSLINE MED/20035722
- Stein S; Weiss A; Adermann K; Lazarovici P; Hochman J; Wellhoner H; Institute of Legal Medicine, University of Hamburg, Germany.
- Conjugates between anti-tetanus F(ab )2 fragments and the (37-72) fragment of the HIV Tat protein were taken up by chromaffin cells, NG108-15 neurohybridoma cells and Rev-2-T-6 lymphoma cells. The uptake could not be inhibited by competition with (37-72)Tat, but was reduced in the presence of metabolic inhibitors or a
- NMR structure of the mature dimer initiation complex of HIV-1 genomic RNA.
- FEBS Lett. 1999 Sep 24;458(3):387-92. Unique Identifier : AIDSLINE MED/20035723
- Mujeeb A; Parslow TG; Zarrinpar A; Das C; James TL; Department of Pharmaceutical Chemistry, University of California; at San Francisco, 94143, USA.
- The two identical genomic RNA strands inside each HIV-1 viral particle are linked through homodimerization of an RNA stem-loop, termed SL1, near their 5 ends. SL1 first dimerizes through a palindromic sequence in its loop, forming a transient kissing-loop complex which then refolds to a mature, linear duplex. We prev
- Accuracy of endoscopic databases for assessing patient symptoms: comparison with self-reported questionnaires in patients infected with the human immunodeficiency virus [see comments]
- Gastrointest Endosc. 2000 Feb;51(2):129-33. Unique Identifier : AIDSLINE MED/20117752
- Corley DA; Cello JP; Koch J; Division of Gastroenterology, and the Gastroenterology Clinical; Outcomes and Epidemiology Research Group, University of; California, San Francisco 94143-0538, USA.
- BACKGROUND: Endoscopic databases are increasingly used for clinical research, but their validity as research instruments has not been assessed. We compared the accuracy of endoscopic indications recorded in an endoscopic database with patient symptom questionnaires. METHODS: All patients infected with the human immuno
- Oral Kaposi's sarcoma in a non-AIDS patient.
- Gen Dent. 1999 Jul-Aug;47(4):413-5. Unique Identifier : AIDSLINE MED/20152088
- Bowie SA Jr; Bach D; Medical University of South Carolina School of Dentistry, USA.
- Kaposi s sarcoma involving the oral cavity is seen frequently in AIDS patients but rarely in transplant patients. When the oral cavity is involved in transplant patients, it usually is located on the palate or the oropharynx. This article reports a renal transplant patient who developed Kaposi s sarcoma which mimicked
- Not all patients are the same: systemic risk factors for adult periodontitis.
- Gen Dent. 1999 Nov-Dec;47(6):580-8. Unique Identifier : AIDSLINE MED/20152068
- Wilson TG; University of Texas at San Antonio Dental School, USA.
- Periodontal diseases are viewed today as multifactoral problems that are initiated and sustained by bacteria but significantly modified by the body s response to bacterial plaque. Local and systemic risk factors are involved in the disease process and both should be included when prognosis and treatment plans are deve
- Long-term immune recovery after CD34+ immunoselected and unselected peripheral blood progenitor cell transplantation: a case-control study.
- Haematologica. 1999 Dec;84(12):1100-3. Unique Identifier : AIDSLINE MED/20054321
- Laurenti L; Sica S; Sora F; Piccirillo N; Ortu La Barbera E; Chiusolo P; Salutari P; Rumi C; Rutella S; Leone G; Divisione di Ematologia, Istituto Semeiotica Medica, Universita; Cattolica Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy.; emacat@rm.unicatt.it
- BACKGROUND AND OBJECTIVE: CD34+ stem cell selection induces extensive T-cell depletion as a consequence of ex vivo manipulation. The impact of T-cell depletion on long-term immunologic recovery after autologous CD34+ peripheral blood progenitor cell transplantation (CD34+ PBPCT) is not well characterized. We compared
- Polymorphisms of the human IFNG gene noncoding regions.
- Immunogenetics. 2000 Jan;51(1):50-8. Unique Identifier : AIDSLINE MED/20130133
- Bream JH; Carrington M; O'Toole S; Dean M; Gerrard B; Shin HD; Kosack D; Modi W; Young HA; Smith MW; Laboratory of Experimental Immunology, National Cancer Institute,; Frederick, Maryland 21702-1201, USA.
- Interferon gamma (IFN-gamma) is a multifunctional cytokine that is essential in the development of Th1 cells and in cellular responses to a variety of intracellular pathogens including human immunodeficiency virus (HIV-1). We screened genomic DNA samples from a predominately Caucasian male population of HIV-infected a
- Diagnostic accuracy of physician review, expert algorithms and data-derived algorithms in adult verbal autopsies.
- Int J Epidemiol. 1999 Dec;28(6):1081-7. Unique Identifier : AIDSLINE MED/20125293
- Quigley MA; Chandramohan D; Rodrigues LC; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
- BACKGROUND: The verbal autopsy (VA) is used to collect information on cause-specific mortality from bereaved relatives. A cause of death may be assigned by physician review of the questionnaires, or by an algorithm. We compared the diagnostic accuracy of physician review, an expert algorithm, and data-derived algorith
- An age-period-cohort analysis of 50,875 AIDS cases among injecting drug users in Europe.
- Int J Epidemiol. 1999 Dec;28(6):1141-8. Unique Identifier : AIDSLINE MED/20125302
- Houweling H; Wiessing LG; Hamers FF; Termorshuizen F; Gill ON; Sprenger MJ; Department of Infectious Diseases Epidemiology, National; Institute of Public Health and the Environment (RIVM), Bilthoven,; The Netherlands. hans.houweling@gr.nl
- BACKGROUND: The long average incubation time from HIV infection to AIDS makes it difficult to estimate recent HIV transmission from AIDS incidence data. Age-period-cohort (APC) analysis can separate out the effects of age, calendar time and birth cohort to provide a clearer picture of transmission trends. METHODS: AID
- Trends in HIV and AIDS based on HIV/AIDS surveillance data in Japan.
- Int J Epidemiol. 1999 Dec;28(6):1149-55. Unique Identifier : AIDSLINE MED/20125303
- Matsuyama Y; Hashimoto S; Ichikawa S; Nakamura Y; Kidokoro T; Umeda T; Kamakura M; Kimura S; Fukutomi K; Ikeda C; Kihara M; Biostatistics/Epidemiology and Preventive Health Sciences, School; of Health Sciences and Nursing, University of Tokyo, Japan.; matuyama@epistat.m.u-tokyo.ac.jp
- BACKGROUND: In recent years a decline in the number of new AIDS cases has been observed in several industrialized countries. It is important to know whether these recent trends observed in North America and Europe are also occurring in Japan . METHODS: The number of people reported w
- AIDS incidence and survival in a hospital-based cohort of asymptomatic HIV seropositive patients in Sao Paulo, Brazil.
- Int J Epidemiol. 1999 Dec;28(6):1156-60. Unique Identifier : AIDSLINE MED/20125304
- Fonseca LA; Reingold AL; Casseb JR; Brigido LF; Duarte AJ; University of California, Berkeley, School of Public Health, USA.
- BACKGROUND: In spite of the high incidence of AIDS in Brazil , few studies have tried to evaluate the prognosis of asymptomatic HIV seropositive Brazilian patients. METHODS: A hospital outpatient facility-based cohort of HIV seropositive asymptomatic subjects was followed to determi
- The deadly return of tuberculosis.
- Int Nurs Rev. 1999 Nov-Dec;46(6):176-7, 180. Unique Identifier : AIDSLINE MED/20139159
- Harrington J
- South Africa responds to a TB emergency [interview]
- Int Nurs Rev. 1999 Nov-Dec;46(6):178, 181. Unique Identifier : AIDSLINE MED/20139160
- Molefe M
- A strong nursing role in tuberculosis control [interview]
- Int Nurs Rev. 1999 Nov-Dec;46(6):179, 182. Unique Identifier : AIDSLINE MED/20139161
- Boutotte J
- Kininogens and kallikrein in pruritic papular eruption.
- Immunopharmacology. 1999 Dec;45(1-3):115-20. Unique Identifier : AIDSLINE MED/20080662
- Reis ML; Maeda S; Rosatelli JB; Donadi EA; Roselino AM; Laboratory of Pharmacology, Faculty of Pharmaceutical Science,; University of Sao Paulo, Ribeirao Preto, SP, Brazil.; mldreis@usp.br
- Pruritic papular eruption (PPE) is a common inflammatory cutaneous lesion observed only in HIV/AIDS patients. Since kinin is an important mediator in inflammation, we evaluated the levels of total kininogen (TKg), low and high molecular weight kininogen (LKg and HKg, respectively) and the activity of kallikrein in pla
- Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant.
- Immunopharmacology. 2000 Jan;46(1):29-37. Unique Identifier : AIDSLINE MED/20127543
- Azuma T; Watanabe N; Yagisawa H; Hirata H; Iwamura M; Kobayashi Y; Department of Biomolecular Science, Faculty of Science, Toho; University, Funabashi, Chiba, Japan.
- Two types of immunosuppressants, cycloprodigiosin hydrochloride (cPrG) and L-leucyl-L-leucine methyl ester (LeuLeuOMe), both have the ability to selectively inhibit the lysosomal function, and a related compound to cPrG, prodigiosin 25-C, and LeuLeuOMe have been reported to selectively inhibit the T cell function in v
- Mexican and Mexican American women in a battered women's shelter: barriers to condom negotiation for HIV/AIDS prevention.
- Issues Ment Health Nurs. 1999 Jul-Aug;20(4):333-55. Unique Identifier : AIDSLINE MED/20089362
- Davila YR; Brackley MH; University of Texas Health Science Center, San Antonio, USA.
- Anecdotal information suggests that, for Hispanic women who are involved with abusive partners, condom use request as an HIV/AIDS sexual risk-reduction behavior may expose the women to risk of both abuse and HIV/AIDS. A qualitative study explored barriers to condom negotiation for HIV/AIDS prevention among Mexican and
- HLA-class I-specific inhibitory receptors in HIV-1 infection.
- Hum Immunol. 2000 Jan;61(1):74-81. Unique Identifier : AIDSLINE MED/20122090
- De Maria A; Moretta L; Department of Internal Medicine, University of Genova, Italy.
- One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou
- beta-lactams: variations on a chemical theme, with some surprising biological results.
- J Antimicrob Chemother. 1999 Dec;44(6):729-34. Unique Identifier : AIDSLINE MED/20059773
- Hamilton-Miller JM; Department of Medical Microbiology, Royal Free and University; College Medical School, London, UK. j.hamilton-miller@rfhsm.ac.uk
- Cost-effectiveness of azithromycin for preventing Mycobacterium avium complex infection in HIV-positive patients in the era of highly active antiretroviral therapy.The Swiss HIV Cohort Study.
- Unique Identifier : AIDSLINE MED/20059784
- Sendi PP; Craig BA; Meier G; Pfluger D; Gafni A; Opravil M; Battegay M; Bucher HC
- We conducted a cost-effectiveness analysis to determine the clinical and economic consequences of Mycobacterium avium complex (MAC) prophylaxis in HIV-infected patients in the era of highly active antiretroviral therapy (HAART) in a health care system with access unrestricted by financial barriers. The analysis was pe
- beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.
- J Biol Chem. 2000 Jan 28;275(4):2479-85. Unique Identifier : AIDSLINE MED/20112807
- Cheng ZJ; Zhao J; Sun Y; Hu W; Wu YL; Cen B; Wu GX; Pei G; Shanghai Institute of Cell Biology, Chinese Academy of Sciences,; Shanghai 200031, People's Republic of China.
- The chemokine receptor CXCR4 has recently been shown to be a co-receptor involved in the entry of human immunodeficiency virus type 1 into target cells. This study shows that coexpression of beta-arrestin with CXCR4 in human embryonic kidney 293 cells attenuated chemokine-stimulated G protein activation and inhibition
- The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells.
- J Biol Chem. 2000 Jan 28;275(4):2654-60. Unique Identifier : AIDSLINE MED/20112831
- Rohr O; Schwartz C; Hery C; Aunis D; Tardieu M; Schaeffer E; Unite 338 INSERM, 5 rue Blaise Pascal, 67084 Strasbourg Cedex,; France.
- Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system and plays a direct role in the pathogenesis of AIDS dementia . However, the molecular mechanisms underlying HIV-1 expression in the central nervous system are poorly understood. We have recently reported
- Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.
- J Biol Chem. 2000 Jan 28;275(4):2852-8. Unique Identifier : AIDSLINE MED/20112857
- Huang N; Miller WL; Department of Pediatrics, University of California, San; Francisco, San Francisco, California 94143-0978, USA.
- The cholesterol side-chain cleavage enzyme, cytochrome P450scc, initiates the biosynthesis of all steroid hormones. Adrenal and gonadal strategies for P450scc gene transcription are essentially identical and depend on the orphan nuclear receptor steroidogenic factor-1, but the placental strategy for transcription of P
- Stability-activity relationships of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors. A basis for anti-HIV drug design.
- J Biol Chem. 2000 Feb 4;275(5):3421-30. Unique Identifier : AIDSLINE MED/20119302
- Jing N; De Clercq E; Rando RF; Pallansch L; Lackman-Smith C; Lee S; Hogan ME; Department of Molecular Physiology, Baylor College of Medicine,; Houston, Texas 77030, USA.
- Recently, we have demonstrated that T30695, a G-tetrad-forming oligonucleotide, is a potent inhibitor of human immunodeficiency virus, type I (HIV-1) integrase and the K(+)-induced loop folding of T30695 plays a key role in the inhibition of HIV-1 integrase (Jing, N., and Hogan, M. E. (1998) J. Biol. Chem. 273, 34992-
- Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.
- J Biol Chem. 2000 Feb 4;275(5):3693-8. Unique Identifier : AIDSLINE MED/20119335
- Choi J; Liu RM; Kundu RK; Sangiorgi F; Wu W; Maxson R; Forman HJ; Department of Molecular Pharmacology, University of Southern; California School of Pharmacy, Los Angeles, California 90033,; USA.
- Human immunodeficiency virus (HIV) progressively depletes GSH content in humans. Although the accumulated evidence suggests a role of decreased GSH in the pathogenesis of HIV, significant controversy remains concerning the mechanism of GSH depletion, especially in regard to envisioning appropriate therapeutic strategi
- HTLV-1-induced cell fusion is limited at two distinct steps in the fusion pathway after receptor binding.
- J Cell Sci. 2000 Jan;113 ( Pt 1):37-44. Unique Identifier : AIDSLINE MED/20059810
- Daenke S; Booth S; Nuffield Department of Clinical Medicine, University of Oxford,; John Radcliffe Hospital, Oxford OX3 9DU, UK.; sdaenke@molbiol.ox.ac.uk.
- Human T-cell leukemia virus type 1 (HTLV-1) is notable among retroviruses for its poor ability to infect permissive cells, particularly as cell free virus. The virus is most efficiently transmitted between individuals by infected cells, where it is presumed that intracellular particles and viral RNA are transferred to
- Viral sexually transmitted infections: current management strategies.
- J Clin Pharm Ther. 1999 Dec;24(6):409-14. Unique Identifier : AIDSLINE MED/20117867
- Tariq A; Ross JD; Department of GU Medicine, New Cross Hospital, Wolverhampton,; U.K.
- Viral sexually transmitted infections are a major health problem associated with considerable morbidity. This article reviews the current strategies used in the management of infections such as genital warts, genital herpes and molluscum contagiosum. Pros and cons of different ts
- Neurocognitive complaints in HIV-infection and their relationship to depressive symptoms and neuropsychological functioning.
- J Clin Exp Neuropsychol. 1999 Dec;21(6):737-56. Unique Identifier : AIDSLINE MED/20119371
- Rourke SB; Halman MH; Bassel C; Department of Psychiatry, University of Toronto, ONT, Canada.; sean.rourke@utoronto.ca
- We examined the degree to which depressive symptoms, clinical staging of HIV disease, and neuropsychological (NP) functioning were related to neurocognitive complaints in HIV-infection. One hundred adults with HIV-infection (12 asymptomatic, 41 mildly symptomatic, and 47 with AIDS) were administered NP tests of attents
- Neuropsychiatric correlates of memory-metamemory dissociations in HIV-infection.
- J Clin Exp Neuropsychol. 1999 Dec;21(6):757-68. Unique Identifier : AIDSLINE MED/20119372
- Rourke SB; Halman MH; Bassel C; Department of Psychiatry, University of Toronto, ONT, Canada.; sean.rourke@utoronto.ca
- Ninety-one adults with HIV-infection who varied in the concordance between their subjective memory complaints (or metamemory) on the Patient s Assessment of Own Functioning (Chelune, Heaton, & Lehman, 1986) and their memory performance on the California Verbal Learning Test (CVLT), were compared on the Beck Depress
- Effects of depressed mood versus clinical depression on neuropsychological test performance among African American men impacted by HIV/AIDS.
- J Clin Exp Neuropsychol. 1999 Dec;21(6):769-83. Unique Identifier : AIDSLINE MED/20119373
- Richardson MA; Satz PF; Myers HF; Miller EN; Bing EG; Fawzy FI; Maj M; Department of Psychiatry, Neuropsychiatric Institute, University; of California, Los Angeles, CA, USA. Mark.Richardson@bmc.org
- The utility of self-report measures in identifying those at risk for depressive disorder and the adverse impact of depression versus depressed mood and HIV serostatus on neuropsychological (NP) test performance were examined in a large sample (N = 243) of gay and bisexual African American men. Results indicate high ra
- Clinical application of the Quantiplex HCV RNA 2.0 and Amplicor HCV Monitor assays for quantifying serum hepatitis C virus RNA.
- J Clin Pathol. 1999 Nov;52(11):807-11. Unique Identifier : AIDSLINE MED/20154758
- Yu ML; Chuang WL; Chen SC; Lin ZY; Hsieh MY; Wang LY; Chang WY; Department of Internal Medicine, Kaohsiung Medical College; Hospital, Taiwan, Republic of China.
- AIM: To compare the performance characteristics and clinical application of two different technologies for quantifying serum hepatitis C virus (HCV) RNA levels. METHODS: HCV RNA was quantified by Amplicor HCV Monitor assay (Amplicor) and Quantiplex HCV RNA 2.0 assay (bDNA-2) in 119 sera from 107 HCV infected patients.
- Multiple eruptive dermatofibromas in a patient with HIV infection: case report and literature review.
- J Cutan Pathol. 2000 Jan;27(1):54-6. Unique Identifier : AIDSLINE MED/20123529
- Kanitakis J; Carbonnel E; Delmonte S; Livrozet JM; Faure M; Claudy A; Department of Dermatology, Hopital Ed. Herriot, Lyon, France.; kanitak@lyon151.inserm.fr
- Multiple eruptive dermatofibromas have been reported in the setting of autoimmune diseases treated with immunosuppressive drugs and more recently in the course of human immunodeficiency virus (HIV) infection. We report herein the ninth case of multiple eruptive dermato fibromas associated with HIV infection. The relev
- PCR-derived ssDNA probes for fluorescent in situ hybridization to HIV-1 RNA.
- J Histochem Cytochem. 2000 Feb;48(2):285-94. Unique Identifier : AIDSLINE MED/20107151
- Knuchel MC; Graf B; Schlaepfer E; Kuster H; Fischer M; Weber R; Cone RW; Division of Infectious Diseases, Department of Internal Medicine,; University Hospital Zurich, Zurich, Switzerland.
- We developed a simple and rapid technique to synthesize single-stranded DNA (ssDNA) probes for fluorescent in situ hybridization (ISH) to human immunodeficiency virus 1 (HIV-1) RNA. The target HIV-1 regions were amplified by the polymerase chain reaction (PCR) and were simultaneously labeled with dUTP. This product se
- Hospital infection control in an era of HIV infection and multi-drug resistant tuberculosis.
- J Hosp Infect. 2000 Jan;44(1):5-11. Unique Identifier : AIDSLINE MED/20100801
- Hannan MM; Azadian BS; Gazzard BG; Hawkins DA; Hoffman PN; Medical Microbiology Department, Department of HIV/GUM, Chelsea; and Westminster Hospital, 369 Fulham Rd, SW10 9NH, UK.
- Tuberculosis infection control in hospitals has received renewed interest after decades of low prominence following the occurrence of multiply drug-resistant strains in populations of patients with immune systems affected by HIV. This paper examines the history of tuberculosis infection control in hospitals and how re
- Human anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDS.
- J Immunol Methods. 1999 Dec 10;231(1-2):223-38. Unique Identifier : AIDSLINE MED/20115642
- Marasco WA; LaVecchio J; Winkler A; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, 44 Binney Street, Boston, MA; 02115, USA. wayne_marasco@dfci.harvard.edu
- The early successes of highly active anti-retroviral therapies (HAART) for the treatment of HIV-1-infection and AIDS have raised the question as to whether there is a legitimate role for gene therapy in the treatment of this chronic infectious disease. However, in many patients the profound suppression of viral replic
- The immunomodulatory role of CD4-positive cytotoxic T-lymphocytes in health and disease.
- Int Rev Immunol. 1999;18(5-6):449-64. Unique Identifier : AIDSLINE MED/20136450
- Hahn S; Erb P; Institute for Medical Microbiology, University of Basel,; Switzerland.
- Among the CD4-positive (CD4+) T-lymphocytes a population exists which expresses cytolytic activity. These killer cells belong to the T helper type 1 (Th1) subset and if activated, express Fas-ligand (FasL) which induces apoptosis in Fas-positive target cells. The major targets of these CD4+ cytotoxic T-lymphocytes (
- Limited access to antiretroviral therapy for intravenous drug users in Europe [letter]
- J Epidemiol Community Health. 1999 Nov;53(11):739. Unique Identifier : AIDSLINE MED/20121559
- Schrooten W; Fleerackers Y; Andraghetti R; Dreezen C; Finazzi R; Caldeira L; Colebunders R
- Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus.
- J Gen Virol. 2000 Feb;81 Pt 2:407-14. Unique Identifier : AIDSLINE MED/20112902
- Jones CM; Cose SC; McNally JM; Jennings SR; Heath WR; Carbone FR; Department of Pathology, Monash Medical School, Commercial Road,; Prahran, Victoria 3181, Australia.
- We have shown that C57BL/6-derived CD8(+) CTL specific for an immunodominant herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) determinant express a highly conserved Vbeta10/junctional sequence combination. This extreme T cell receptor beta-chain bias can be used to track the activation of gB-specific CTL in lym
- Changes of leukocyte phenotype and function in the broncho-alveolar lavage fluid of pigs infected with porcine reproductive and respiratory syndrome virus: a role for CD8(+) cells.
- J Gen Virol. 2000 Feb;81 Pt 2:497-505. Unique Identifier : AIDSLINE MED/20112912
- Samsom JN; de Bruin TG; Voermans JJ; Meulenberg JJ; Pol JM; Bianchi AT; Department of Mammalian Virology, Institute for Animal Science; and Health, NL-8200 AB Lelystad, The Netherlands.; jn.samsom.cell@med.vu.nl
- Porcine reproductive and respiratory virus (PRRSV) primarily infects and destroys alveolar macrophages of the pig. The aim of the present study was to characterize the changes of leukocyte populations in the broncho-alveolar lavage fluid (BALF) of PRRSV-infected pigs. Piglets were inoculated intranasally with PRRSV st
- Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an in vivo model.
- J Gen Virol. 2000 Feb;81 Pt 2:507-13. Unique Identifier : AIDSLINE MED/20112913
- van Der Ende ME; Guillon C; Boers PH; Gruters RA; Racz P; Tenner-Racz K; Osterhaus AD; Schutten M; Department of Virology, Erasmus Medical Centre Rotterdam, Dr; Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
- The pathogenic properties of four primary human immunodeficiency virus type 2 (HIV-2) isolates and two primary HIV-2 biological clones were studied in an in vivo human-to-mouse chimeric model. The cell-associated viral load and the ability to reduce the severity of the induced graft-versus-host disease symptoms, the C
- Spread of distinct human immunodeficiency virus type 1 AG recombinant lineages in Africa.
- J Gen Virol. 2000 Feb;81 Pt 2:515-23. Unique Identifier : AIDSLINE MED/20112914
- Cornelissen M; van Den Burg R; Zorgdrager F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; University of Amsterdam, Meibergdreef 45, 1105BA Amsterdam, The; Netherlands. M.I.Cornelissen@amc.uva.nl
- To identify new subtype G human immunodeficiency virus type 1 (HIV-1) strains and AG recombinant forms, we collected 28 serum samples from immigrants to the Netherlands from 12 countries throughout Africa. Based on the gag sequences 22 isolates were identified as subtype A or
- Serinol-derived malyngamides from an Australian cyanobacterium.
- J Nat Prod. 1999 Dec;62(12):1698-9. Unique Identifier : AIDSLINE MED/20119915
- Wan F; Erickson KL; Carlson School of Chemistry, Clark University, Worcester,; Massachusetts 01610, USA.
- Serinol derivatives 4a and 4b were isolated from an Australian blue-green alga and characterized by spectroscopic means. Their absolute stereochemistry was established by chemical methods.
- Enhanced analytical sensitivity of a quantitative PCR for CMV using a modified nucleic-acid extraction procedure.
- J Clin Lab Anal. 2000;14(1):32-7. Unique Identifier : AIDSLINE MED/20112963
- Ferreira-Gonzalez A; Yanovich S; Langley MR; Weymouth LA; Wilkinson DS; Garrett CT; Department of Pathology, Medical College of Virginia Campus of; Virginia Commonwealth University, Richmond, Virginia 23298-0248,; USA. agonzalez@hsc.vcu.edu
- Accurate and rapid diagnosis of CMV disease in immunocompromised individuals remains a challenge. Quantitative polymerase chain reaction (QPCR) methods for detection of CMV in peripheral blood mononuclear cells (PBMC) have improved the positive and negative pred
- Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern.
- J Pathol. 1999 Jun;188(2):133-8. Unique Identifier : AIDSLINE MED/99359586
- Delecluse HJ; Hummel M; Marafioti T; Anagnostopoulos I; Stein H; Consultation and Reference Centre for Lymph Node Pathology and; Hematopathology, Institute of Pathology, Klinikum Benjamin; Franklin, Free Univerisity of Berlin, Germany.
- HIV-infected patients are at high risk of developing diffuse large B-cell lymphomas (DLBCL). It is currently unclear whether these lymphomas represent Epstein-Barr virus (EBV)-driven lymphoproliferations that develop in the setting of immunodeficiency, or whether these tumours are more closely related to the DLBCL see
- Cytokine secretion profiles of cloned T cells from human aortic atherosclerotic plaques.
- J Pathol. 1999 Jun;188(2):174-9. Unique Identifier : AIDSLINE MED/99359592
- de Boer OJ; van der Wal AC; Verhagen CE; Becker AE; Department of Cardiovascular Pathology, Academic Medical Center,; University of Amsterdam, Amsterdam, The Netherlands.
- T cells take part in the chronic inflammatory reaction in atherosclerotic plaques, but their specific role in atherosclerosis has not yet been fully elucidated. Nevertheless, one may anticipate that activated T cells may secrete cytokines capable of modulating the morphology and hence the stability of plaques by regul
- Antibody responses to a mucosally delivered HIV-1 gp120-derived C4/V3 peptide.
- J Reprod Immunol. 1999 Dec;45(2):99-112. Unique Identifier : AIDSLINE MED/20137444
- Zinckgraf JW; Winchell JM; Silbart LK; University of Connecticut, Department of Molecular and Cell; Biology, Storrs 06269, USA.
- T1-SP10MN(A) is a synthetic peptide containing a T-helper (Th), cytotoxic T cell (CTL) and a B-cell epitope derived from the HIV-1 gp120 envelope protein. This peptide can elicit both systemic and mucosal antibody responses following nasal immunization in various species. In the present study, three different mucosal
- Signaling activities of gammaherpesvirus membrane proteins.
- J Virol. 2000 Feb;74(4):1593-601. Unique Identifier : AIDSLINE MED/20111276
- Damania B; Choi JK; Jung JU; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.
- The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites.
- J Virol. 2000 Feb;74(4):1632-40. Unique Identifier : AIDSLINE MED/20111280
- Lim SP; Garzino-Demo A; Institute of Molecular and Cell Biology, Singapore 117609,; Singapore.
- It has been shown that the human immunodeficiency virus type 1 (HIV-1) Tat protein can specifically enhance expression and release of monocyte chemoattractant protein 1 (MCP-1) from human astrocytes. In this study, we show evidence that Tat-induced MCP-1 expression is mediated at the transcriptional level. Transient t
- Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus.
- J Virol. 2000 Feb;74(4):1648-57. Unique Identifier : AIDSLINE MED/20111282
- Giavedoni LD; Velasquillo MC; Parodi LM; Hubbard GB; Hodara VL; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78245, USA.; Lgiavedoni@icarus.sfbr.org
- We studied the innate and adaptive immune system of rhesus macaques infected with the virulent simian immunodeficiency virus isolate SIVmac251 by evaluating natural killer (NK) cell activity, cytokine levels in plasma, humoral and virological parameters, and changes in the activation markers CD25 (interleukin 2R :IL-2
- The central proline of an internal viral fusion peptide serves two important roles.
- J Virol. 2000 Feb;74(4):1686-93. Unique Identifier : AIDSLINE MED/20111286
- Delos SE; Gilbert JM; White JM; Department of Cell Biology, University of Virginia Health System,; School of Medicine, Charlottesville, Virginia 22908, USA.
- The fusion peptide of the avian sarcoma/leukosis virus (ASLV) envelope protein (Env) is internal, near the N terminus of its transmembrane (TM) subunit. As for most internal viral fusion peptides, there is a proline near the center of this sequence. Robson-Garnier structure predictions of the ASLV fusion peptide and i
- Multiepitopic B- and T-cell responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine.
- J Virol. 2000 Feb;74(4):1694-703. Unique Identifier : AIDSLINE MED/20111287
- Gah:ery-S:egard H; Pialoux G; Charmeteau B; Sermet S; Poncelet H; Raux M; Tartar A; L:evy JP; Gras-Masse H; Guillet JG; Laboratoire d'Immunologie des Pathologies Infectieuses et; Tumorales, INSERM Unit:e 445, Institut Cochin de G:en:etique; Mol:eculaire, Universit:e Ren:ee Descartes, H^opital Cochin,; 75014 Paris, France. gahery@icgm.cochin.inserm.fr
- We have attempted to develop an anti-human immunodeficiency virus (HIV) lipopeptide vaccine with several HIV-specific long peptides modified by C-terminal addition of a single palmitoyl chain. A mixture of six lipopeptides derived from regulatory or structural HIV-1 proteins (Nef, Gag, and Env) was prepared. A phase I
- Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques.
- J Virol. 2000 Feb;74(4):1704-11. Unique Identifier : AIDSLINE MED/20111288
- Rosenwirth B; ten Haaft P; Bogers WM; Nieuwenhuis IG; Niphuis H; Kuhn EM; Bischofberger N; Heeney JL; Uberla K; Departments of Virology and Animal Science, Biomedical Primate; Research Center, 2288 GJ Rijswijk, The Netherlands.
- A limited period of chemotherapy during primary immunodeficiency virus infection might provide a long-term clinical benefit even if treatment is initiated at a time point when virus is already detectable in plasma. To evaluate this strategy, we infected rhesus macaques with the pathogenic simian/human immunodeficiency
- Diminished human immunodeficiency virus type 1 reverse transcription and nuclear transport in primary macrophages arrested in early G(1) phase of the cell cycle.
- J Virol. 2000 Feb;74(4):1712-7. Unique Identifier : AIDSLINE MED/20111289
- Kootstra NA; Zwart BM; Schuitemaker H; Department of Clinical Viral-Immunology, Central Laboratory of; the Netherlands Red Cross Blood Transfusion Service, Academic; Medical Center, University of Amsterdam, 1066 CX Amsterdam, The; Netherlands.
- Previously, we and others have demonstrated that the process of reverse transcription of human immunodeficiency virus type 1 (HIV-1) is disturbed in nondividing macrophages and quiescent T lymphocytes. Here we analyzed which phase of the cell cycle in macrophages is crucial for early steps in the HIV-1 replication cyc
- Multiple integrations of human foamy virus in persistently infected human erythroleukemia cells.
- J Virol. 2000 Feb;74(4):1718-26. Unique Identifier : AIDSLINE MED/20111290
- Meiering CD; Comstock KE; Linial ML; Division of Basic Sciences, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.
- Foamy viruses are complex retroviruses whose replication strategy resembles that of conventional retroviruses. However, foamy virus replication also resembles that of hepadnaviruses in many respects. Because hepadnaviruses replicate in an integrase-independent manner, we were interested in investigating the characteri
- Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA.
- J Virol. 2000 Feb;74(4):1767-74. Unique Identifier : AIDSLINE MED/20111296
- Van Rompay KK; Miller MD; Marthas ML; Margot NA; Dailey PJ; Canfield DR; Tarara RP; Cherrington JM; Aguirre NL; Bischofberger N; Pedersen NC; California Regional Primate Research Center, University of; California, Davis, California 95616, USA. kkvanrompay@ucdavis.edu
- Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study pathogenesis and to develop intervention strategies aimed at preventing infection or delaying disease progression. In previous studies, we demonstrated that 9-:2-(R)-(phosphonomethoxy)propyladeni
- Abundant defective viral particles budding from microglia in the course of retroviral spongiform encephalopathy.
- J Virol. 2000 Feb;74(4):1775-80. Unique Identifier : AIDSLINE MED/20111297
- Hansen R; Czub S; Werder E; Herold J; Gosztonyi G; Gelderblom H; Schimmer S; Mazgareanu S; ter Meulen V; Czub M; Institut f]ur Virologie und Immunbiologie, Universit]at; W]urzburg, D-97078 W]urzburg, Germany.
- A pathogenetic hallmark of retroviral neurodegeneration is the affinity of neurovirulent retroviruses for microglia cells, while degenerating neurons are excluded from retroviral infections. Microglia isolated ex vivo from rats peripherally infected with a neurovirulent retrovirus released abundant mature type C virio
- Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha.
- J Virol. 2000 Feb;74(4):1787-93. Unique Identifier : AIDSLINE MED/20111299
- Maeda Y; Foda M; Matsushita S; Harada S; Department of Biodefence and Medical Virology, School of; Medicine, Kumamoto University, Kumamoto, Japan.; ymaeda@kaiju.medic.kumamoto-u.ac.jp
- To determine whether C-C chemokines play an important role in the phenotype switch of human immunodeficiency virus (HIV) from CCR5 to CXCR4 usage during the course of an infection in vivo, macrophage inflammatory protein (MIP)-1alpha-resistant variants were isolated from CCR5-tropic (R5) HIV-1 in vitro. The selected v
- Expanded host cell tropism and cytopathic properties of feline immunodeficiency virus strain PPR subsequent to passage through interleukin-2-independent T cells.
- J Virol. 2000 Feb;74(4):1854-63. Unique Identifier : AIDSLINE MED/20111306
- Lerner DL; Elder JH; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.
- A cytopathic variant of feline immunodeficiency virus (FIV) strain PPR emerged after passage of wild-type virus on an interleukin-2-independent cell line. The virus, termed FIV-PPRglial, displayed a phenotype markedly different from the parental virus, including the ability to productively infect previously refractory
- The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cells.
- J Virol. 2000 Feb;74(4):1871-84. Unique Identifier : AIDSLINE MED/20111308
- Holtappels R; Thomas D; Podlech J; Geginat G; Steffens HP; Reddehase MJ; Institute for Virology, Johannes Gutenberg University, 55101; Mainz, Germany.
- Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation to cytolytic T lymphocytes (CTL). Specifically, the m152 gene product gp37/40 c
- Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120.
- J Virol. 2000 Feb;74(4):1948-60. Unique Identifier : AIDSLINE MED/20111316
- Moulard M; Lortat-Jacob H; Mondor I; Roca G; Wyatt R; Sodroski J; Zhao L; Olson W; Kwong PD; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, 13288 Marseille Cedex; 9, France.
- It is well established that the gp120 V3 loop of T-cell-line-adapted human immunodeficiency virus type 1 (HIV-1) binds both cell-associated and soluble polyanions. Virus infectivity is increased by interactions between HIV-1 and heparan sulfate proteoglycans on some cell types, and soluble polyanions such as heparin a
- Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus.
- Unique Identifier : AIDSLINE MED/20111317
- Kwong PD; Wyatt R; Sattentau QJ; Sodroski J; Hendrickson WA
- The human immunodeficiency virus envelope glycoproteins, gp120 and gp41, function in cell entry by binding to CD4 and a chemokine receptor on the cell surface and orchestrating the direct fusion of the viral and target cell membranes. On the virion surface, three gp120 molecules associate noncovalently with the ectodo
- CXC-chemokine receptor 4 is not a coreceptor for human herpesvirus 7 entry into CD4(+) T cells.
- J Virol. 2000 Feb;74(4):2011-6. Unique Identifier : AIDSLINE MED/20111322
- Zhang Y; Hatse S; De Clercq E; Schols D; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, B-3000 Leuven, Belgium. Ying.Zhang@rega.kuleuven.ac.be
- Human herpesvirus 7 (HHV-7) is a T-lymphotropic virus which utilizes the CD4 receptor as its main receptor to enter the target cells. Hence, HHV-7 can interfere with human immunodeficiency virus type 1 (HIV-1) infection in CD4(+) T cells. It was recently suggested that the CXC chemokine receptor 4 (CXCR4), which was f
- Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.
- J Virol. 2000 Feb;74(4):2023-8. Unique Identifier : AIDSLINE MED/20111324
- de Quiros JC; Shupert WL; McNeil AC; Gea-Banacloche JC; Flanigan M; Savage A; Martino L; Weiskopf EE; Imamichi H; Zhang YM; Adelsburger J; Stevens R; Murphy PM; Zimmerman PA; Hallahan CW; Davey RT Jr; Connors M; Servicio de Medicina Interna 1, Clinica Puerta de Hierro,; Universidad Autonoma de Madrid, and Servicio de Microbiologia,; Hospital General Gregorio Maranon, Madrid, Spain.
- High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative re
- Pathogenic conversion of live attenuated simian immunodeficiency virus vaccines is associated with expression of truncated Nef.
- J Virol. 2000 Feb;74(4):2038-45. Unique Identifier : AIDSLINE MED/20111326
- Sawai ET; Hamza MS; Ye M; Shaw KE; Luciw PA; Department of Medical Pathology, University of California, Davis,; California 95616, USA.
- Rhesus macaques infected with simian immunodeficiency virus (SIV) containing either a large nef deletion (SIVmac239Delta(152)nef) or interleukin-2 in place of nef developed high virus loads and progressed to simian AIDS. Viruses recovered from both juvenile and neonatal macaques with disease produced a novel truncated
- Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels.
- JAMA. 2000 Feb 9;283(6):763-70. Unique Identifier : AIDSLINE MED/20145260
- Bhasin S; Storer TW; Javanbakht M; Berman N; Yarasheski KE; Phillips J; Dike M; Sinha-Hikim I; Shen R; Hays RD; Beall G; Division of Endocrinology, Metabolism, and Molecular Medicine,; Charles R. Drew University of Medicine and Science, Los Angeles,; CA 90059, USA. sbhasin@ucla.edu
- CONTEXT: Previous studies of testosterone supplementation in HIV-infected men failed to demonstrate improvement in muscle strength. The effects of resistance exercise combined with testosterone supplementation in HIV-infected men are unknown. OBJECTIVE: To determine the effects of testosterone replacement with and wit
- Genital herpes and public health: addressing a global problem.
- JAMA. 2000 Feb 9;283(6):791-4. Unique Identifier : AIDSLINE MED/20145264
- Corey L; Handsfield HH; Fred Hutchinson Cancer Research Center, Department of Laboratory; Medicine, University of Washington School of Medicine, Seattle; 98109, USA.
- Genital herpes can be caused by herpes simplex virus 2 (HSV-2) or, less commonly, by herpes simplex virus 1 (HSV-1). With a seroprevalence of antibodies to HSV-2 of 22% in the general population, genital herpes is 1 of the 3 most prevalent sexually transmitted diseases (STDs) in
- Access to antiretroviral therapy [letter]
- JAMA. 2000 Feb 16;283(7):883-4; discussion 884. Unique Identifier : AIDSLINE MED/20148141
- Bassetti S; Battegay M; Sudre P
- Access to antiretroviral therapy [letter]
- JAMA. 2000 Feb 16;283(7):884. Unique Identifier : AIDSLINE MED/20148142
- Bartlett JG
- Sicca syndrome and HTLV-I-associated myelopathy/tropical spastic paraparesis.
- Jpn J Ophthalmol. 1999 Nov-Dec;43(6):509-12. Unique Identifier : AIDSLINE MED/20135435
- Merle H; Cabre P; Smadja D; Josset P; Landau M; Vernant JC; Service d'Ophtalmologie, Centre Hospitalier Universitaire de Fort; de France, Martinique, French West Indies.
- PURPOSE: The objective of this study is to describe the clinical and immunological aspects observed in patients with both human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis and ocular dryness. METHODS: In 15 such patients, clinical and biological examinations completed with a bio
- Molecular profile of Epstein-Barr virus infection in HHV-8-positive primary effusion lymphoma.
- Leukemia. 2000 Feb;14(2):271-7. Unique Identifier : AIDSLINE MED/20139548
- Fassone L; Bhatia K; Gutierrez M; Capello D; Gloghini A; Dolcetti R; Vivenza D; Ascoli V; Coco FL; Pagani L; Dotti G; Rambaldi A; Raphael M; Tirelli U; Saglio G; Magrath IT; Carbone A; Gaidano G; Division of Internal Medicine, Department of Medical Sciences,; Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
- Primary effusion lymphoma (PEL) selectively involves the serous body cavities, occurs predominantly in immunodeficient patients and is infected consistently by human herpesvirus type-8. PEL is also frequently infected by Epstein-Barr virus (EBV). The precise pathogenetic role of EBV coinfection in PEL is not fully und
- The tyrosine kinase receptor met and its ligand HGF are co-expressed and functionally active in HHV-8 positive primary effusion lymphoma.
- Leukemia. 2000 Feb;14(2):285-91. Unique Identifier : AIDSLINE MED/20139550
- Capello D; Gaidano G; Gallicchio M; Gloghini A; Medico E; Vivenza D; Buonaiuto D; Fassone L; Avanzi GC; Saglio G; Prat M; Carbone A; Division of Internal Medicine, Department of Medical Sciences,; Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
- Primary effusion lymphoma (PEL) harbors consistent infection by human herpesvirus-8, preferentially develops in immunodeficient patients and selectively localizes to the serous body cavities. Histogenetic analysis has suggested that PEL originates from post-germinal center, pre-terminally differentiated B cells sharin
- Improvement of anemia induced by parvovirus B19 in a patient with AIDS after combined antiretroviral therapy [letter]
- Mayo Clin Proc. 2000 Feb;75(2):215-6. Unique Identifier : AIDSLINE MED/20147288
- Scapellato PG; Palumbo AM; Del Valle S
- [A neck abscess due to Streptococcus pneumoniae in a man with HIV infection (letter)]
- Med Clin (Barc). 1999 Dec 11;113(20):795-6. Unique Identifier : AIDSLINE MED/20144399
- Javaloyas M; Vallet J; Sueiras A; Gonzalez X
- HIV/AIDS cases in 1999 set to keep increasing into the next century [news]
- Lancet. 1999 Nov 27;354(9193):1886. Unique Identifier : AIDSLINE MED/20049432
- Ashraf H
- Condoms banned from Israel's anti-AIDS campaign [news]
- Lancet. 1999 Nov 27;354(9193):1887. Unique Identifier : AIDSLINE MED/20049433
- Fishman RH
- Global trade and access to medicines: AIDS treatments in Thailand.
- Lancet. 1999 Nov 27;354(9193):1893-5. Unique Identifier : AIDSLINE MED/20049436
- Wilson D; Cawthorne P; Ford N; Aongsonwang S; Medecins Sans Frontieres, Bangkok, Thailand.; msfbthai@asianet.co.th
- Infant-feeding patterns and HIV-1 transmission [letter; comment]
- Lancet. 1999 Nov 27;354(9193):1901; discussion 1902. Unique Identifier : AIDSLINE MED/20049438
- Shaffer N; Van de Perre P; de Vincenzi I; Bertolli J
- Infant-feeding patterns and HIV-1 transmission [letter; comment]
- Lancet. 1999 Nov 27;354(9193):1901-2. Unique Identifier : AIDSLINE MED/20049439
- Matchaba PT
- Infant-feeding patterns and HIV-1 transmission [letter; comment]
- Lancet. 1999 Nov 27;354(9193):1903-4. Unique Identifier : AIDSLINE MED/20049441
- Smith MM; Kuhn L
- Unrecognised Mycobacterium tuberculosis [letter]
- Lancet. 2000 Jan 8;355(9198):143. Unique Identifier : AIDSLINE MED/20137652
- David T; Brahmadathan KN; Mukundan UD; John TJ
- Indinavir concentrations and St John's wort [letter]
- Lancet. 2000 Feb 12;355(9203):547-8. Unique Identifier : AIDSLINE MED/20145212
- Piscitelli SC; Burstein AH; Chaitt D; Alfaro RM; Falloon J
- St John s wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitu
- Experts hear sobering side of HIV-1 treatment story [news]
- Lancet. 2000 Feb 12;355(9203):555. Unique Identifier : AIDSLINE MED/20145219
- Morris K
- South Africa's AIDS taskforce questioned [news]
- Lancet. 2000 Feb 12;355(9203):558. Unique Identifier : AIDSLINE MED/20145223
- Baleta A
- Either a CD4(+)or CD8(+)T cell function is sufficient for clearance of infectious virus from trigeminal ganglia and establishment of herpes simplex virus type 1 latency in mice.
- Microb Pathog. 1999 Dec;27(6):387-94. Unique Identifier : AIDSLINE MED/20057964
- Ghiasi H; Perng G; Nesburn AB; Wechsler SL; Ophthalmology Research, Cedars-Sinai Burns and Allen Research; Institute, CSMC - Davis Bldg, Rm 5072, 8700 Beverly Blvd, Los; Angeles, CA, 90048, USA.
- Following ocular infection of normal mice, herpes simplex virus type 1 (HSV-1) establishes a latent infection in the trigeminal ganglia (TG) with the complete absence of detectable infectious virus. In this study, the role of CD4(+)and CD8(+)T cell dependent immune responses is examined in relation to clearing infecti
- Genetic identification of Candida species in HIV-positive patients using the polymerase chain reaction and restriction fragment length polymorphism analysis of its DNA.
- Mol Cell Probes. 1999 Dec;13(6):401-6. Unique Identifier : AIDSLINE MED/20126215
- Irobi J; Schoofs A; Goossens H; Department of Biochemistry, University of Antwerp, UIA, Antwerp,; Belgium. jirobi@uia.ua.ac.be
- The polymerase chain reaction was used to amplify a targeted region: an internal transcribed spacer region of the ribosomal DNA from 114 Candida isolates and 65 reference strains. Unique product sizes were obtained for Candida glabrata, C. guillermondii and C. inconspicua. Isolates of C. albicans, C. tropicalis, C. du
- Idiopathic eosinophilia [letter]
- N Engl J Med. 2000 Mar 2;342(9):660; discussion 660-1. Unique Identifier : AIDSLINE MED/20143088
- Suzuki R; Seto M; Nakaura S
- New drugs 2000. Part I.
- Nursing. 2000 Jan;30(1):55-62; quiz 63-4. Unique Identifier : AIDSLINE MED/20161213
- Hussar DA; Philadelphia College of Pharmacy, University of the Sciences,; Pa., USA.
- Adherence to antiretroviral therapy by pregnant women infected with human immunodeficiency virus: a pharmacy claims-based analysis.
- Obstet Gynecol. 2000 Feb;95(2):167-73. Unique Identifier : AIDSLINE MED/20137039
- Laine C; Newschaffer CJ; Zhang D; Cosler L; Hauck WW; Turner BJ; Division of General Internal Medicine, the Center for Research in; Medical Education and Health Care, Jefferson Medical College of; Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
- OBJECTIVE: To assess adherence to antiretroviral therapy with the use of Medicaid pharmacy claims data for human immunodeficiency virus (HIV)-infected pregnant women and to identify associated maternal and health care factors. METHODS: We retrospectively studied a cohort of 2714 HIV-infected women in New York State wh
- Scintigraphic imaging of sarcomatous tumors with [(111)In-DTPA-phe-1]-octreotide.
- Oncology. 2000;58(1):18-24. Unique Identifier : AIDSLINE MED/20113037
- Giannakenas C; Kalofonos HP; Apostolopoulos D; Petsas T; Kalogeropoulou C; Tzorakelefterakis E; Skopa CD; Vassilakos PJ; Department of Nuclear Medicine, Regional University Hospital of; Patras, Rion - Patras, Greece. cgian@med.upatras.gr
- The objective of the present study was to investigate the efficacy of (111)In-DTPA-octreotide (OC) for in vivo scintigraphic imaging of these relatively uncommon tumors. Thirteen patients (9 males, 4 females, mean age 59 years) with known sarcomatous lesions were studied. All patients had known lesions as demonstrated
- Emerging pathogens: Isospora, Cyclospora and microsporidia.
- Unique Identifier : AIDSLINE MED/20126774
- Curry A; Smith HV; Public Health Laboratory, Withington Hospital, Manchester, UK.
- Isospora belli, Cyclospora cayetanensis as well as several species of microsporidia are recognized as emerging protozoan pathogens of humans. All are obligate intracellular parasites, with Isospora and the microsporidia being primarily associated with immunocompromised hosts. Cyclospora is a cause of traveller s diarr
- Human immunodeficiency virus reverse transcriptase and protease sequence database.
- Nucleic Acids Res. 2000 Jan 1;28(1):346-8. Unique Identifier : AIDSLINE MED/20063304
- Shafer RW; Jung DR; Betts BJ; Xi Y; Gonzales MJ; Department of Medicine, Stanford University, Stanford, CA 94305,; USA. rshafer@cmgm.stanford.edu
- The HIV RT and Protease Sequence Database is an online relational database that catalogs evolutionary and drug-related human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease sequence variation (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protea
- Prevention strategies other than male condoms employed by low-income women to prevent HIV infection.
- Public Health Nurs. 2000 Jan-Feb;17(1):53-60. Unique Identifier : AIDSLINE MED/20137518
- Crosby RA; Yarber WL; Meyerson B; Behavioral Interventions and Research Branch, Division of; Sexually Transmitted Disease Prevention, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA. rqc4@cdc.gov
- This study sought to determine HIV prevention strategies other than male condom use employed by low-income women who have sex with men (WSM) and to identify variables that predict use of these strategies. A cross-sectional survey of nearly 4,000 women receiving Women, Infants, and Children (WIC) benefits in 21 Missour
- Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability.
- Pharm Res. 1999 Dec;16(12):1812-7. Unique Identifier : AIDSLINE MED/20106883
- Yu L; Bridgers A; Polli J; Vickers A; Long S; Roy A; Winnike R; Coffin M; Glaxo Wellcome, Inc., Research Triangle Park, North Carolina; 27709, USA. yul@eder.fda.gov
- PURPOSE: To investigate the effect of vitamin E-TPGS, d-alpha-tocopheryl polyethylene glycol 1000 succinate, on the solubility and permeability of amprenavir , a potent HIV protease inhibitor. METHODS: The aqueous solubility of amprenavir was measured
- Tablet dissolution affected by a moisture mediated solid-state interaction between drug and disintegrant.
- Pharm Res. 1999 Dec;16(12):1850-6. Unique Identifier : AIDSLINE MED/20106889
- Rohrs BR; Thamann TJ; Gao P; Stelzer DJ; Bergren MS; Chao RS; Pharmaceutical Development, Pharmacia & Upjohn, Kalamazoo,; Michigan 49001, USA. brian.r.rohrs@am.pnu.com
- PURPOSE: To investigate the cause for decrease in delavirdine mesylate 200 mg tablet dissolution upon exposure to high humidity. METHODS: Dissolution testing was performed using the USP 2 (paddle) apparatus. Water in tablets was measured by Karl Fisch
- [Therapeutic management of HIV-infected subjects. Report of the expert group under the direction of Prof. J.F. Delfraissy, 1999]
- Presse Med. 2000 Jan 15;29(1):25-8. Unique Identifier : AIDSLINE MED/20146634
- [Therapeutic management of HIU-infected persons. Interview with A, Sobel]
- Presse Med. 2000 Jan 15;29(1):28-31. Unique Identifier : AIDSLINE MED/20146635
- Sobel A
- [HIV infection in Africa. Clinical and therapeutical research]
- Presse Med. 2000 Jan 29;29(3):146-52. Unique Identifier : AIDSLINE MED/20151584
- Salamon R; Anglaret X; Leroy V; Dabis F; Unite INSERM 330, Universite Victor Segalen Bordeaux 2.; Roger.Salamon@dim.u-bordeaux2.fr
- A MAJOR HEALTH PROBLEM: Human Immunodeficiency Virus (HIV) infection is a major public health problem in sub-Saharan Africa and the care of HIV-infected patients is limited by the lack of resources. Clinical research can play a major role to assess the benefit of preventive and/or curative measures adapted to the cont
- [The 39th ICAAC (San Francisco, September 1999). HIV infection in clinical practice]
- Presse Med. 2000 Jan 29;29(3):153-4. Unique Identifier : AIDSLINE MED/20151585
- Piketty C; Unite d'Immunologie clinique, Hopital Broussais, Paris.
- Incremental cost-effectiveness of two zidovudine regimens to prevent perinatal HIV transmission in the United States.
- Prev Med. 2000 Jan;30(1):64-9. Unique Identifier : AIDSLINE MED/20111383
- Pinkerton SD; Holtgrave DR; Layde PM; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee,; Wisconsin 53202, USA. pinkrton@mcw.edu
- BACKGROUND: Recently concluded clinical trials in Thailand have demonstrated that a short course of zidovudine therapy administered to human immunodeficiency virus-infected women during late pregnancy and labor can substantially reduce the likelihood of perinatal transmission of
- T cell receptor interactions with class I heavy-chain influence T cell selection.
- Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):756-60. Unique Identifier : AIDSLINE MED/20105545
- Kuhns ST; Tallquist MD; Johnson AJ; Mendez-Fernandez Y; Pease LR; Departments of Biochemistry and Molecular Biology, Mayo; Clinic/Foundation, Rochester, MN 55905, USA.
- The interaction of the T cell receptor (TCR) with peptide in the binding site of the major histocompatibility complex molecule provides the basis for T cell recognition during immune surveillance, repertoire development, and tolerance. Little is known about the extent to which repertoire selection is influenced direct
- Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion.
- Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):805-10. Unique Identifier : AIDSLINE MED/20105554
- Steinberger P; Andris-Widhopf J; Buhler B; Torbett BE; Barbas CF 3rd; Skaggs Institute for Chemical Biology and Department of Molecular; Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
- Studies of naturally occurring polymorphisms of the CCR5 gene have shown that deletion of the functional receptor or reduced expression of the gene can have beneficial effects in preventing HIV-1 infection or delaying disease. Because these polymorphisms are found in otherwise healthy people, strategies that aim to pr
- Cationic microparticles: A potent delivery system for DNA vaccines.
- Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):811-6. Unique Identifier : AIDSLINE MED/20105555
- Singh M; Briones M; Ott G; O'Hagan D; Chiron Vaccines, Chiron Corporation, 4560 Horton Street,; Emeryville, CA 94608, USA.
- An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection. The microparticles released intact and functional DNA over 2 weeks in vitro. In addition, the microparticles induced hi
- HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells.
- Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1178-83. Unique Identifier : AIDSLINE MED/20122591
- Cicala C; Arthos J; Rubbert A; Selig S; Wildt K; Cohen OJ; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA. CCicala@nih.gov
- Binding of HIV type 1 (HIV-1) envelope glycoproteins to the surface of a CD4(+) T cell transduces intracellular signals through the primary envelope receptor, CD4, and a coreceptor, either CCR5 or CXCR4. Furthermore, envelope-CD4(+) cell interactions increase rates of apoptosis in peripheral blood mononuclear cells (P
- In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline.
- Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1269-74. Unique Identifier : AIDSLINE MED/20122607
- Blaak H; van't Wout AB; Brouwer M; Hooibrink B; Hovenkamp E; Schuitemaker H; Department of Clinical Viro-Immunology, CLB, and Laboratory for; Experimental and Clinical Immunology, Academic Medical Center,; University of Amsterdam, Plesmanlaan 125, 1066CX Amsterdam, The; Netherlands.
- Switch from non-syncytium-inducing (NSI) to syncytium-inducing (SI) HIV type 1 (HIV-1) is associated with accelerated CD4(+) T cell depletion, which might partially be explained by higher virulence of SI variants compared with NSI variants. Because NSI and SI variants use different coreceptors for entry of target cell
- Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes.
- Radiology. 2000 Feb;214(2):427-32. Unique Identifier : AIDSLINE MED/20138658
- Edinburgh KJ; Jasmer RM; Huang L; Reddy GP; Chung MH; Thompson A; Halvorsen RA Jr; Webb RA; Dept of Radiology, Univ of California, San Francisco, USA.; kedinburgh@subrad.com
- PURPOSE: To determine whether the computed tomographic (CT) appearances of multiple pulmonary nodules in patients with acquired immunodeficiency syndrome (AIDS) can help differentiate the potential infectious and neoplastic causes. MATERIALS AND METHODS: The thoracic CT scans obtained in 60 patients with AIDS and mult
- Casein kinase 2 as a potentially important enzyme in the nervous system.
- Prog Neurobiol. 2000 Feb;60(3):211-46. Unique Identifier : AIDSLINE MED/20121729
- Blanquet PR; Unite de Recherche de Physiopharmacologie du Systeme Nerveux,; U-161 INSERM, Paris, France. u161@broca.inserm.fr
- Protein kinase CK2 is a ubiquitous and pleiotropic seryl/threonyl protein kinase which is highly conserved in evolution indicating a vital cellular role for this kinase. The holoenzyme is generally composed of two catalytic (alpha and/or alpha ) and two regulatory (beta) subunits, but the free alpha/alpha subunits ar
- Using AIDS mortality data to reconstruct HIV/AIDS epidemics.
- Stat Med. 2000 Jan 30;19(2):161-74. Unique Identifier : AIDSLINE MED/20109177
- Mariotto AB; Verdecchia A; Istituto Superiore di Sanita, Viale Regina Elena 299, Roma; 00161, Italy.
- The back-calculation methods used to reconstruct HIV epidemics and to predict future AIDS cases use data on the number of AIDS reported cases and information about the time from HIV infection to AIDS diagnosis. In this paper we modify a back-calculation method, presented in Verdecchia and Mariotto, to estimate HIV inc
- Uncertainty of AIDS incubation time and its effects on back-calculation estimates.
- Stat Med. 2000 Jan 30;19(2):175-89. Unique Identifier : AIDSLINE MED/20109178
- Gigli A; Verdecchia A; Istituto per le Applicazioni del Calcolo, Consiglio Nazionale; delle Ricerche, Viale del Policlinico 137, 00161 Roma, Italy.; GIGLI@IAC.RM.CNR.IT
- Incubation time is the period from the onset of HIV infection to AIDS. The distribution of the incubation time is one of the main parameters of the back-calculation method for the estimation of incidence of HIV infection. Because of the long and variable incubation time, the assessment of its distribution is uncertain
- R(2): a useful measure of model performance when predicting a dichotomous outcome [letter]
- Stat Med. 2000 Jan 30;19(2):271-4. Unique Identifier : AIDSLINE MED/20109184
- Buyse M
- The relationship between nutritional status and physical activity, ulcer history and ulcer-related problems in patients with leg and foot ulcers.
- Scand J Caring Sci. 1999;13(2):123-8. Unique Identifier : AIDSLINE MED/20099560
- Wissing U; Unosson M; Department of Medicine and Care, Faculty of Health Sciences,; Linkoping University, Sweden.
- The nutritional status in patients with leg and foot ulcers is assessed in relation to sociodemographic data, mobility, physical activity, ulcer history, and ulcer-related problems from the patients point of view. The patients (20 men and 50 women, mean age 79 years) were living in their own homes and treatment was g
- [Hepatitis B: when to use lamivudine?]
- Schweiz Med Wochenschr. 2000 Jan 11;130(1-2):39-41. Unique Identifier : AIDSLINE MED/20134942
- Renner EL; Abteilung fur Gastroenterologie und Hepatologie,; Universitatsspital Zurich. gasree@usz.unizh.ch
- Social network methods for endemic foci of syphilis: a pilot project [see comments]
- Sex Transm Dis. 2000 Jan;27(1):12-8. Unique Identifier : AIDSLINE MED/20119023
- Rothenberg R; Kimbrough L; Lewis-Hardy R; Heath B; Williams OC; Tambe P; Johnson D; Schrader M; Department of Family and Preventive Medicine, Emory University; School of Medicine, Atlanta, Georgia 30333, USA.; rrothen@emory.edu
- BACKGROUND: Social network methods have improved our understanding of sexually transmitted disease transmission dynamics, and may be of use in routine field operations for partner notification. GOAL: To augment traditional syphilis-control activities with social network methods in an Atlanta area with high syphilis mo
- Human immunodeficiency virus infection and genital ulcer disease in South Africa: the herpetic connection [see comments]
- Sex Transm Dis. 2000 Jan;27(1):21-9. Unique Identifier : AIDSLINE MED/20119025
- Chen CY; Ballard RC; Beck-Sague CM; Dangor Y; Radebe F; Schmid S; Weiss JB; Tshabalala V; Fehler G; Htun Y; Morse SA; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA.
- BACKGROUND AND OBJECTIVES: While genital ulcers are a risk factor in HIV infection, the association of specific agents of genital ulcer disease (GUD) with HIV infection may vary. GOAL: To determine the etiology of GUD in HIV-infected and HIV-uninfected men attending sexually transmitted disease (STD) clinics in Durban
- Herpes simplex type 2 infection in the developing world: is it time to address this disease? [editorial; comment]
- Sex Transm Dis. 2000 Jan;27(1):30-1. Unique Identifier : AIDSLINE MED/20119026
- Corey L
- HIV prevalence in patients with syphilis, United States.
- Sex Transm Dis. 2000 Jan;27(1):53-9. Unique Identifier : AIDSLINE MED/20119031
- Blocker ME; Levine WC; St. Louis ME; Epidemiology and Surveillance Branch, Division of STD Prevention,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia, USA.
- BACKGROUND: Among persons with a sexually transmitted disease (STD), the proportion who are also infected with HIV is a major factor influencing the public health impact of that STD on HIV transmission. GOAL: To assess HIV infection in persons with syphilis in the United States . STUDY
- More of the same is not validation [letter]
- Sex Transm Dis. 2000 Jan;27(1):60-1. Unique Identifier : AIDSLINE MED/20119032
- Potterat JJ; Brody S
- [Antitubercular agents]
- Ther Umsch. 1999 Dec;56(12):687-90. Unique Identifier : AIDSLINE MED/20103629
- Gartmann J; Ehemalige Kantonal-Zurcherische Hohenklinik Altein, Arosa.
- The personally experienced development of chemotherapy for tuberculosis during the last half century represents some highlights of new knowledges and practical successes: the discovery of antituberculosis drugs; the comprehension of their actions and side effects; the exploration of mechanisms of resistance against an
- Tuberculosis diagnosed during pregnancy: a prospective study from London.
- Thorax. 2000 Feb;55(2):129-32. Unique Identifier : AIDSLINE MED/20107267
- Llewelyn M; Cropley I; Wilkinson RJ; Davidson RN; Wellcome Centre for Clinical Tropical Medicine, Imperial College; School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, UK.
- BACKGROUND: A study was undertaken to characterise the presentation of tuberculosis in pregnancy and the difficulties in diagnosis in an area of the UK with a high incidence of tuberculosis. METHODS: A prospective case series was investigated at Northwick Park Hospital, a university affiliated district general hospita
- The CC-chemokine receptor 5 (CCR5) is a marker of, but not essential for the development of human Th1 cells.
- Tissue Antigens. 1999 Dec;54(6):572-7. Unique Identifier : AIDSLINE MED/20137436
- Odum N; Bregenholt S; Eriksen KW; Skov S; Ryder LP; Bendtzen K; Van Neerven RJ; Svejgaard A; Garred P; Institute of Medical Microbiology and Immunology, The Panum; Institute, Copenhagen, Denmark.
- The CC-chemokine receptor 5 (CCR5) has recently been described as a surface marker of human T cells producing type 1 (Th1) cytokines. Here we confirm that CCR5 is expressed on human Th1 but not on Th2 T-cell clones. Using intracellular cytokine staining, we show that alloantigen specific CD4+ T-cell lines derived from
- Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4.
- Toxicol Appl Pharmacol. 2000 Jan 15;162(2):77-85. Unique Identifier : AIDSLINE MED/20105579
- Vandebriel RJ; De Jong WH; Spiekstra SW; Van Dijk M; Fluitman A; Garssen J; Van Loveren H; Laboratory for Pathology and Immunobiology, National Institute of; Public Health and the Environment, Bilthoven, 3720 BA, The; Netherlands. r.vandebriel@rivm.nl
- The local lymph node assay (LLNA) is a new and promising test in mice used to identify contact allergens by means of dermal exposure. Experimentally this assay, which comprises a sensitizing phase only, is also used to identify respiratory allergens. Another, experimentally used test in mice to identify allergens is a
- Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator.
- Virology. 2000 Jan 20;266(2):246-56. Unique Identifier : AIDSLINE MED/20107278
- Nekhai S; Shukla RR; Fernandez A; Kumar A; Lamb NJ; Department of Biochemistry, George Washington University School; of Medicine, Washington, DC, 20037, USA.
- Activation of the HIV-1 promoter by the virally encoded Tat protein is characterized by efficient processive transcription, mediated by host cell factors that are tethered to the promoter with the Tat-TAR RNA complex. Importantly, viral gene activation has been shown to be stimulated in mitogenically induced cells, al
- Defining parameters for successful immunocytotherapy of persistent viral infection.
- Virology. 2000 Jan 20;266(2):257-63. Unique Identifier : AIDSLINE MED/20107279
- Berger DP; Homann D; Oldstone MB; Division of Virology, Department of Neuropharmacology, The; Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla,; California, 92037, USA.
- Persistent infections with viruses such as HIV, Epstein-Barr virus, cytomelagovirus, and hepatitis B and C viruses continue to be major human health problems. Immunocytotherapy for persistent viral infections has proven successful in animal models but less effective in humans. While the requirement of antigen-specific
- Implication of the C-terminal domain of nef protein in the reversion to pathogenicity of attenuated SIVmacBK28-41 in macaques.
- Virology. 2000 Jan 20;266(2):286-98. Unique Identifier : AIDSLINE GENBANK/AF128391
- Lafont BA; Riviere Y; Gloeckler L; Beyer C; Hurtrel B; Paule Kieny M; Kirn A; Aubertin AM; INSERM U-74 et Laboratoire de Virologie, 3 rue Koeberle,; Strasbourg, 67000, France.
- We have analyzed the nef gene sequences amplified from 12 macaques presenting various patterns of infection with SIVmacBK28-41, a clone derived from attenuated SIVmacBK28. We have observed seven mutation hot spots at positions 56, 75, 432, 588, 680, 699, and 779. The major alteration was a thymidine insertion at posit
- Changes in a murine leukemia virus (MLV) receptor encoded by an alphavirus vector during passage in cells expressing the MLV envelope.
- Virology. 2000 Feb 1;267(1):124-32. Unique Identifier : AIDSLINE MED/20115974
- Kazachkov Y; Long D; Wang C; Silver J; Laboratory of Molecular Microbiology, National Institutes of; Health, Bethesda, Maryland, 20892, USA.
- We constructed alphavirus vectors encoding the ecotropic murine leukemia virus (MLV) receptor mCAT1. Cells electroporated with these vector RNAs expressed mCAT1 protein and fused with cells that expressed a fusogenic form of the MLV envelope on the cell surface. Electroporated cells also released submicron particles t
- Incorporation of simian virus 5 fusion protein into murine leukemia virus particles and its effect on the co-incorporation of retroviral envelope glycoproteins.
- Virology. 2000 Feb 1;267(1):49-57. Unique Identifier : AIDSLINE MED/20115967
- Hatziioannou T; Russell SJ; Cosset FL; Laboratoire de Vectorologie Retrovirale et Therapie Genique,; INSERM U412, Lyon Cedex 07, 69364, France.
- We describe the generation of murine leukemia virus (MLV) virus particles carrying the paramyxovirus fusion protein F from simian virus 5 (SV5-F). This glycoprotein was expressed in cells providing Moloney MLV (MoMLV) Gag and Pol proteins and a lacZ retroviral vector. SV5-F was correctly expressed, processed, and effi
- Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein.
- Virology. 2000 Feb 1;267(1):8-16. Unique Identifier : AIDSLINE MED/20115963
- Kaneko H; Bednarek I; Wierzbicki A; Kiszka I; Dmochowski M; Wasik TJ; Kaneko Y; Kozbor D; Department of Microbiology, Thomas Jefferson University, 1020; Locust Street, Philadelphia, Pennsylvania, 19107-6799, USA.
- In this report, we described induction of HIV envelope (env)-specific systemic and mucosal immune responses by oral vaccination of BALB/c mice with env-encoded plasmid DNA encapsulated in poly(dl-lactide-co-glycolide) (PLG) microparticles. We demonstrated that intragastric administration of the encapsulated plasmid DN
- HIV protease: enzyme function and drug resistance.
- Vitam Horm. 2000;58:213-56. Unique Identifier : AIDSLINE MED/20133579
- Gulnik S; Erickson JW; Xie D; SAIC Frederick, National Cancer Institute, Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.
- HIV protease is responsible for processing of the gag and gag-pol polyproteins during virion maturation. The activity of this enzyme is essential for virus infectivity, rendering the protein a major therapeutic target for AIDS treatment. This articles reviews the biochemical and biophysical properties of the enzyme. T
- Autoimmune diseases in families of French patients with multiple sclerosis.
- Acta Neurol Scand. 2000 Jan;101(1):36-40. Unique Identifier : AIDSLINE MED/20123546
- Heinzlef O; Alamowitch S; Sazdovitch V; Chillet P; Joutel A; Tournier-Lasserve E; Roullet E; Department of Neurology, Hospital Tenon, Paris, France.
- Multiple sclerosis (MS) is associated with autoimmune disorders (AIDs) in individual patients, and limited data suggest a possible familial association of MS and AIDs; however, no systematic study has been conducted on the occurrence of AIDs in the families of MS patients. Using a standardized interview focused on AID
- Analysis of effector CD4 (OX-40+) and CD8 (CD45RA+CD27-) T lymphocytes in active multiple sclerosis.
- Acta Neurol Scand. 2000 Jan;101(1):57-60. Unique Identifier : AIDSLINE MED/20123550
- Hintzen RQ; Pot K; Paty D; Oger J; Multiple Sclerosis Clinic and Department of Medicine, University; of British Columbia, Vancouver, Canada.
- OBJECTIVE: Recently, effector T-cell subpopulations have been identified that can be distinguished by expression of members of the TNF-R family: CD4+OX-40+ cells are CD4 helper-effector cells CD8+CD45RA+CD27 cells are CD8-killer-effector cells. We investigated whether these lymphocyte subsets were increased in the act
- [Tuberculous orchiepididymitis as clinical onset of human immunodeficiency virus (HIV) infection]
- Actas Urol Esp. 1999 Nov-Dec;23(10):898-9. Unique Identifier : AIDSLINE MED/20135032
- Anglada Curado FJ; Gomez Bermudo J; Carmona Campos E; Blanco Espinosa A; Prieto Castro R; Regueiro Lopez JC; Requena Tapia MJ; Servicio de Urologia, Hospital Regional Universitario Reina; Sofia, Cordoba.
- The emergence of acquired immunodeficiency syndrome has changed the natural history of tuberculosis which has now become the second most common infection associated to human immunodeficiency virus infection. It is only rarely that a tuberculous infection has an urogenital location, and extrapulmonary locations are gen
- Psychosocial correlates of contraceptive practices during late adolescence.
- Adolescence. 1999 Fall;34(135):463-82. Unique Identifier : AIDSLINE MED/20121965
- Lagana L; American School of Professional Psychology, Honolulu, Hawaii; 96816, USA.
- This article reviews the literature on psychosocial correlates of contraceptive practices among sexually active late adolescents (primarily college undergraduates). It seeks to help identify subgroups of adolescents who either do not use or misuse contraceptive means, putting them at risk for unwanted pregnancy, AIDS,
- 1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with HIV: Part III. Prevention of disease recurrence. United States Public Health Service/Infectious Diseases Society of America.
- Am Fam Physician. 2000 Feb 1;61(3):771-8, 780, 785. Unique Identifier : AIDSLINE MED/20158135
- U.S. Department of Health and Human Services, Public Health; Service Centers for Disease Control and Prevention, Atlanta,; Georgia, USA.
- Impact of psychiatric conditions on health-related quality of life in persons with HIV infection.
- Am J Psychiatry. 2000 Feb;157(2):248-54. Unique Identifier : AIDSLINE MED/20137698
- Sherbourne CD; Hays RD; Fleishman JA; Vitiello B; Magruder KM; Bing EG; McCaffrey D; Burnam A; Longshore D; Eggan F; Bozzette SA; Shapiro MF; RAND Health Division, Santa Monica, CA 90407-2138, USA.; Cathy_Sherbourne@rand.org
- OBJECTIVE: Little is known about the impact of comorbid psychiatric symptoms in persons with HIV. This study estimates the burden on health-related quality of life associated with comorbid psychiatric conditions in a nationally representative sample of persons with HIV. METHOD: The authors conducted a multistage sampl
- Epstein-Barr virus-related intravascular lymphomatosis [letter]
- Am J Surg Pathol. 2000 Feb;24(2):309-10. Unique Identifier : AIDSLINE MED/20143138
- Au WY; Shek TW; Kwong YL
- Infectious and tropical diseases in Oman: a review.
- Am J Trop Med Hyg. 1999 Dec;61(6):920-5. Unique Identifier : AIDSLINE MED/20137136
- Scrimgeour EM; Mehta FR; Suleiman AJ; Department of Medicine, Sultan Qaboos University, Al-Khod,; Muscat, Sultanate of Oman.
- Oman is generally hot and dry, but the Salalah region in southern Dhofar province is relatively cool and rainy during the summer monsoon, and has a distinctive pattern of infection. Important, notifiable infections in Oman include t
- Apoptosis in coxsackievirus B3-induced myocarditis and dilated cardiomyopathy.
- Ann N Y Acad Sci. 1999;887:181-90. Unique Identifier : AIDSLINE MED/20133653
- Huber SA; Budd RC; Rossner K; Newell MK; Department of Pathology, University of Vermont, Burlington 05405,; USA. shuber(a)salus.uvm.edu
- Group B coxsackieviruses (CVB), which infect the myocardium, cause myocarditis and dilated cardiomyopathy. However, not all infections of the myocardium result in disease. In the mouse model, CVB infection stimulates autoimmune T cell response to cardiac antigens, and these autoimmune effectors cause myocyte necrosis
- Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS. Molecular control and effect of highly active anti-retroviral therapy.
- Ann N Y Acad Sci. 1999;887:199-212. Unique Identifier : AIDSLINE MED/20133655
- Gougeon ML; Montagnier L; Unite d'Oncologie Virale and CNRS ERS 572, Departement SIDA et; Retrovirus, Institut Pasteur, Paris, France. mlgougeo@pasteur.fr
- Infection with human immunodeficiency virus (HIV) results in the progressive destruction of CD4 T lymphocytes, generally associated with progression of the disease. The progressive disappearance of CD4 T lymphocytes leads to the lack of control of HIV replication and to the development of severe immune deficiency resp
- Inhibition of beta-globin gene expression by 3'-azido-3'-deoxythymidine in human erythroid progenitor cells.
- Antiviral Res. 1999 Dec 31;44(3):167-77. Unique Identifier : AIDSLINE MED/20114490
- Spiga MG; Weidner DA; Trentesaux C; LeBoeuf RD; Sommadossi JP; Department of Biochemistry and Molecular Biology, School of; Medicine, University of Miami, FL 33136, USA.
- 3 -Azido-3 -deoxythymidine ( AZT ) treatment in HIV-infected patients is limited by bone marrow suppression including neutropenia and anemia. Previous studies had shown a direct effect of high concentrations of this drug on globin gene expression in K-5
- T-cell clones from early-stage cutaneous T-cell lymphoma show no polarized Th-1 or Th-2 cytokine profile.
- Unique Identifier : AIDSLINE MED/20129441
- Harwix S; Zachmann K; Neumann C
- Recent studies of the cytokine pattern in skin lesions of patients with cutaneous T-cell lymphoma (CTCL) have shown that interleukin-4 (IL-4) and Il-10, both cytokines produced by T-helper type 2 cells, dominate in these lesions. Also, in single studies, interferon-gamma (IFN-gamma), a major cytokine of
- Preventive intervention to reduce sexually transmitted infections: a field trial in the Royal Thai Army.
- Arch Intern Med. 2000 Feb 28;160(4):535-40. Unique Identifier : AIDSLINE MED/20158241
- Celentano DD; Bond KC; Lyles CM; Eiumtrakul S; Go VF; Beyrer C; na Chiangmai C; Nelson KE; Khamboonruang C; Vaddhanaphuti C; School of Hygiene and Public Health, The Johns Hopkins; University, Baltimore, MD 21205, USA. dcelenta@jhsph.edu
- BACKGROUND: During 1991 through 1993, sexually transmitted infections among conscripts in the Royal Thai Army in the upper-northern provinces were common: human immunodeficiency virus (HIV) prevalence at induction was 12%, HIV incidence was 2.4% per year, and incidence of sexually transmitted diseases was 17% per year
- Outcomes of intensive care for patients with human immunodeficiency virus infection.
- Unique Identifier : AIDSLINE MED/20158242
- Nickas G; Wachter RM; Department of Medicine, University of California, San Francisco,; USA.
- BACKGROUND: Intensive care for patients with human immunodeficiency virus is common, costly, and associated with high morbidity. Accurate and up-to-date outcome and prognostic data are needed to effectively counsel patients and to make difficult decisions regarding admission to the intensive care unit. METHODS: We rev
- Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immunodeficiency virus type 1 promoter.
- J Biol Chem. 1999 Nov 12;274(46):33114-22. Unique Identifier : AIDSLINE MED/20020290
- Mischiati C; Borgatti M; Bianchi N; Rutigliano C; Tomassetti M; Feriotto G; Gambari R; Department of Biochemistry, Ferrara University, 44100 Ferrara,; Italy.
- We determined whether peptide nucleic acids (PNAs) are able to interact with NF-kappaB p52 transcription factor. The binding of NF-kappaB p52 to DNA-DNA, DNA-PNA, PNA-DNA, and PNA-PNA hybrid molecules carrying the NF-kappaB binding sites of human immunodeficiency type 1 long terminal repeat was studied by (i) biospeci
- Saquinavir therapy in patients with the advanced HIV infection and liver cirrhosis.
- Jpn J Infect Dis. 1999 Aug;52(4):177-8. Unique Identifier : AIDSLINE MED/20060490
- Tachikawa N; Yoshizawa S; Kikuchi Y; Yasuoka A; Oka S; AIDS Clinical Center, International Medical Center of Japan,; Tokyo.
- HIV disease-related neutropenia: an independent risk factor for severe infections.
- AIDS. 1999;13 Suppl 2:S11-7. Unique Identifier : AIDSLINE MED/20061790
- Hermans P; Department of Internal Medicine, CHU Saint-Pierre, Brussels,; Belgium. crmiclum@ulb.ac.be
- An increasing number of clinical studies have been reported in which neutropenia has been identified as an important independent risk factor in the development of infectious complications in patients with HIV and AIDS. Information on the clinical significance of infecting pathogens and the causes of neutropenia within
- Characterization of active reverse transcriptase and nucleoprotein complexes of the yeast retrotransposon Ty3 in vitro.
- Unique Identifier : AIDSLINE MED/20062890
- Cristofari G; Gabus C; Ficheux D; Bona M; Le Grice SF; Darlix JL; LaboRetro, Unite de Virologie Humaine, INSERM (#412), Ecole; Normale Superieure de Lyon, 69364 Lyon Cedex 07, France.
- Human immunodeficiency virus (HIV) and the distantly related yeast Ty3 retrotransposon encode reverse transcriptase (RT) and a nucleic acid-binding protein designated nucleocapsid protein (NCp) with either one or two zinc fingers, required for HIV-1 replication and Ty3 transposition, respectively. In vitro binding of
- [Clinical analysis of Pseudomonas aeruginosa bacteremia]
- Rinsho Byori. 1999 Nov;47(11):1064-9. Unique Identifier : AIDSLINE MED/20058190
- Kumasaka K; Hosokawa N; Yanai M; Yagoshi M; Simoguchi K; Kawano K; Department of Clinical Pathology, Nihon University School of; Medicine, Tokyo.
- To determine the outcome of Pseudomonas aeruginosa bacteremia and to identify risk factors for these infections in our University hospital, 46 cases (65 episodes) of Pseudomonas aeruginosa bacteremia were retrospectively investigated. The most frequent underlying diseases or cases were from Emergency and Critical care
- Necrotising fasciitis in a HIV positive male: an unusual indication for abdomino-perineal resection.
- Ir J Med Sci. 1999 Oct-Dec;168(4):251-3. Unique Identifier : AIDSLINE MED/20089490
- Caird J; Abbasakoor F; Quill R; Department of General Surgery, St. James's Hospital, Dublin.
- We report a case of necrotising fasciitis of the genitoperineum (Fournier s gangrene) in a HIV positive male following incision and drainage of bilateral ischiorectal fossa abscesses. During surgery to debride the necrotic tissue the rectum was found to be perforated necessitating laparotomy and subsequent abdomino-pe
- The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.
- J Exp Med. 2000 Jan 3;191(1):33-46. Unique Identifier : AIDSLINE MED/20088890
- Jacotot E; Ravagnan L; Loeffler M; Ferri KF; Vieira HL; Zamzami N; Costantini P; Druillennec S; Hoebeke J; Briand JP; Irinopoulou T; Daugas E; Susin SA; Cointe D; Xie ZH; Reed JC; Roques BP; Kroemer G; Centre National de la Recherche Scientifique, F-94801 Villejuif,; France.
- Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr cause a rapid dissipation of the mitochondrial transmembrane potential (DeltaPsi(m)), as well as the mitochondrial release of apoptogeni
- Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia.
- Leuk Lymphoma. 1999 Nov;35(5-6):607-11. Unique Identifier : AIDSLINE MED/20075890
- Sakai R; Maruta A; Tomita N; Taguchi J; Fujisawa S; Ogawa K; Motomura S; Kodama F; Mohri H; Ishigatsubo Y; Department of Hematology and Chemotherapy, Kanagawa Cancer; Center, Yokahama-shi, Japan.
- A 34-year-old woman of HTLV-I carrier with T-PLL, whose quality of life improved and survival was prolonged after splenectomy, is described. The patient had marked splenomegaly, generalized lymphadenopathy and marked proliferation of abnormal lymphocytes in the peripheral blood with an irregular nucleus, deeply basoph
- T-cell function in the human newborn [letter]
- Immunol Today. 2000 Feb;21(2):107-8. Unique Identifier : AIDSLINE MED/20119152
- Hassan I; Reen DJ
- The role of CpG motifs in innate immunity.
- Curr Opin Immunol. 2000 Feb;12(1):35-43. Unique Identifier : AIDSLINE MED/20145578
- Krieg AM; Department of Veterans Affairs Medical Center, Department of; Internal Medicine, University of Iowa College of Medicine, Iowa; City, IA 52242, USA. arthur-krieg@uiowa.edu
- Pattern recognition receptors of the innate immune system are able to distinguish certain prokaryotic DNAs from vertebrate DNAs by detecting unmethylated CpG dinucleotides in particular base contexts ( CpG motifs ). Recent studies have begun to define the molecular mechanisms of actions of CpG motifs and have demonstr
- The role of IL-18 in innate immunity.
- Curr Opin Immunol. 2000 Feb;12(1):59-63. Unique Identifier : AIDSLINE MED/20145581
- Akira S; Department of Host Defense, CREST of Japan Science and Technology; Corporation, Research Institute for Microbial Diseases, Osaka; University, Suita, 565-0871, Japan. sakira@biken.osaka-u.ac.jp
- IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient i
- Rational antigen modification as a strategy to upregulate or downregulate antigen recognition.
- Curr Opin Immunol. 2000 Feb;12(1):85-91. Unique Identifier : AIDSLINE MED/20145584
- Abrams SI; Schlom J; Laboratory of Tumor Immunology and Biology, National Cancer; Institute, National Institutes of Health, Bethesda, MD; 20892-1750, USA. sa47z@nih.gov
- Recent and rapid advances in our understanding of the cellular and molecular mechanisms of antigen recognition by CD8(+) and CD4(+) T lymphocytes have led to the birth of possibilities for site-directed, rational modification of cognate antigenic determinants. This immunologic concept has vast biomedical implications
- The stimulation of gene expression by the R region from HTLV-1 and BLV.
- J Biotechnol. 2000 Feb 17;77(2-3):179-89. Unique Identifier : AIDSLINE MED/20146859
- Attal J; Theron MC; Kann G; Bolifraud P; Puissant C; Houdebine LM; Unite de Differenciation Cellulaire, Institut National de la; Recherche Agronomique, Jouy-en-Josas, France.
- The 5 untranslated regions (5 UTR) of mRNA are known to stimulate or inhibit more or less translation. SR alpha, an association of SV40 early gene promoter and of the R region plus the first 39 nucleotides of the U5 region (designated as R) from the human T-cell leukemia virus (HTLV-1) is currently used to stimulate
- Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response? [see comments]
- Am J Respir Cell Mol Biol. 2000 Feb;22(2):139-42. Unique Identifier : AIDSLINE MED/20125649
- von Hertzen LC; Haahtela T; The Finnish Lung Health Association; and Helsinki University; Central Hospital, Skin and Allergy Hospital, Helsinki, Finland.
- Could asthma be worsened by stimulating the T-helper type 1 immune response? [comment]
- Am J Respir Cell Mol Biol. 2000 Feb;22(2):143-6. Unique Identifier : AIDSLINE MED/20125650
- Castro M; Chaplin DD; Walter MJ; Holtzman MJ; Departments of Medicine and Cell Biology, Washington University; School of Medicine, St. Louis, Missouri 63110, USA.; mcastro@im.wustl.edu
- Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs.
- Unique Identifier : AIDSLINE MED/20125655
- Shirota H; Sano K; Kikuchi T
- Recognition of defined epitopes by affinity-purified anti-immunoglobulin fab autoantibodies isolated from HIV-infected humans.
- J Mol Recognit. 1999 May-Jun;12(3):169-76. Unique Identifier : AIDSLINE MED/99326382
- Marchalonis JJ; Garza A; Lake DF; Landsperger WJ; Susal C; Microbiology and Immunology, College of Medicine, Arizona Health; Sciences Center, P.O. Box 24-5049, Tucson AZ 85724, USA.; dianah@u.arizona.edu
- Infection of humans with HIV-1 has previously been independently shown to result in the generation of autoantibodies (AAbs) reactive with immunoglobulin Fab fragments (Heidelberg), and with autoantibodies to T-cell receptors (TCRs) (Tucson). Here, we carry out epitope mapping studies of affinity-purified AAbs to Fab f
- Prediction of the binding energy for small molecules, peptides and proteins.
- J Mol Recognit. 1999 May-Jun;12(3):177-90. Unique Identifier : AIDSLINE MED/99326383
- Schapira M; Totrov M; Abagyan R; Skirball Institute of Biomolecular Medicine, Structural Biology,; New York University Medical Center, 540 First Avenue, New York,; NY 10016, USA.
- A fast and reliable evaluation of the binding energy from a single conformation of a molecular complex is an important practical task. Knowledge-based scoring schemes may not be sufficiently general and transferable, while molecular dynamics or Monte Carlo calculations with explicit solvent are too computationally exp
- Proline affects oligomerization of a coiled coil by inducing a kink in a long helix.
- J Struct Biol. 1999 Dec 30;128(3):270-9. Unique Identifier : AIDSLINE MED/20100643
- Chang DK; Cheng SF; Trivedi VD; Lin KL; Institute of Chemistry, Academia Sinica, Taipei, 115, Taiwan,; Republic of China. dkc@chem.sinica.edu.tw
- The structural effect of a proline in a helix in trifluoroethanol (TFE)/water medium was examined on a 29-mer peptide and its proline analog derived from the leucine zipper (LZ)-like motif of gp41 (the transmembrane glycoprotein of HIV-1) by NMR and circular dichroism (CD) spectroscopies. Lower helical content was fou
- Immune reconstitution after transplantation of autologous peripheral CD34+ cells: analysis of predictive factors and comparison with unselected progenitor transplants.
- Br J Haematol. 2000 Jan;108(1):105-15. Unique Identifier : AIDSLINE MED/20117452
- Rutella S; Rumi C; Laurenti L; Pierelli L; Sora' F; Sica S; Leone G; Department of Haematology, Centre for the Flow Cytometry Study of; Blood Cells, Catholic University School of Medicine, Rome, Italy.
- The recovery of lymphocyte count, CD4+ and CD8+ T-cell subsets, natural killer (NK) cells and CD19+ B-cells was evaluated in a cohort of 15 patients receiving autologous CD34+ peripheral blood progenitor cells (PBPCs; group A) for haematological malignancies and in 20 patients transplanted with autologous unselected P
- Kaposi's sarcoma-associated herpesvirus (KSHV) in bone marrow biopsy from patients with multiple myeloma: PCR amplification of orf26 but not orf72 and orf75 sequences [letter]
- Br J Haematol. 2000 Jan;108(1):197-8. Unique Identifier : AIDSLINE MED/20174501
- Brousset P; Meggetto F; Laharrague P; Attal M; Delsol
- Danish patients with untreated multiple myeloma do not harbour human herpesvirus 8.
- Br J Haematol. 2000 Jan;108(1):96-8. Unique Identifier : AIDSLINE MED/20117450
- Rask C; Kelsen J; Olesen G; Nielsen JL; Obel N; Abildgaard N; Department of Haematology, Aarhus University Hospital, Denmark.
- The role of human herpesvirus 8 (HHV-8) in multiple myeloma (MM) remains controversial. We examined 15 Danish MM patients before cytoreductive therapy. Mononuclear cells isolated from peripheral blood and bone marrow aspirates, as well as long-term cultured bone marrow stromal cells, were assayed for the presence of H
- Diagnosis of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients with polymerase chain reaction: a blinded comparison to standard methods.
- Clin Infect Dis. 2000 Jan;30(1):141-5. Unique Identifier : AIDSLINE MED/20086545
- Torres J; Goldman M; Wheat LJ; Tang X; Bartlett MS; Smith JW; Allen SD; Lee CH; Division of Infectious Diseases and Wishard Memorial Hospital and; Indiana University School of Medicine, Indianapolis, IN 46202,; USA.
- Pneumocystis carinii pneumonia (PCP) is an important cause of morbidity and death among persons with human immunodeficiency virus (HIV) infection. Polymerase chain reaction (PCR) analysis of respiratory specimens has been investigated as a rapid diagnostic method. We have previously reported on the utility of this tec
- Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections.
- Clin Infect Dis. 2000 Jan;30(1):146-51. Unique Identifier : AIDSLINE MED/20086546
- Chien JW; Kucia ML; Salata RA; Division of Infectious Diseases, Case Western Reserve University; School of Medicine, University Hospitals of Cleveland, OH; 44106-5083, USA.
- We report our experience with linezolid in an investigation of its use against resistant gram-positive bacterial infections. Fifteen patients who had renal failure (n=6), recent liver transplantation (n=5) or surgery (n=6), cancer (n=3), endocarditis (n=2), or human immunodeficiency virus infection (n=1), along with i
- Intravenous cidofovir for compassionate use in AIDS patients with cytomegalovirus retinitis. Spanish Cidofovir Study Group.
- Clin Infect Dis. 2000 Jan;30(1):182-4. Unique Identifier : AIDSLINE MED/20086553
- Berenguer J; Mallolas J; Servicio de Microbiologia y Enfermedades Infecciosas, Hospital; Gregorio Maranon, 28007, Madrid, Spain. juaberber@retemail.es
- We report the compassionate use of intravenous cidofovir for the treatment of cytomegalovirus retinitis in 51 patients with AIDS who were receiving highly active antiretroviral therapy (HAART). After a median of 9 doses, 49 patients showed no retinitis activity. However, treatment
- Lactic acidosis associated with stavudine administration: a report of five cases.
- Clin Infect Dis. 2000 Jan;30(1):198-200. Unique Identifier : AIDSLINE MED/20086558
- Mokrzycki MH; Harris C; May H; Laut J; Palmisano J; Montefiore Medical Center, Renal Division, Bronx, NY 10467, USA.; mokrzm@aol.com
- Type B lactic acidosis has been described in patients receiving the nucleoside analogs zidovudine, didanosine, and fialuridine. Lactic acidosis has also been described in 4 patients receiving combination therapy with
- Safety and immunogenicity of preexposure rabies vaccination in children infected with human immunodeficiency virus type 1.
- Clin Infect Dis. 2000 Jan;30(1):218. Unique Identifier : AIDSLINE MED/20086568
- Thisyakorn U; Pancharoen C; Ruxrungtham K; Ubolyam S; Khawplod P; Tantawichien T; Phanuphak P; Wilde H; Department of Pediatrics, Faculty of Medicine, Chulalongkorn; University, Bangkok 10330, Thailand.
- Human immunodeficiency virus-seropositive individual with persistent human herpesvirus 8 infection for >11 years without development of Kaposi's sarcoma.
- Clin Infect Dis. 2000 Jan;30(1):221-2. Unique Identifier : AIDSLINE MED/20086570
- Meng YX; Lam LL; Kite-Powell K; Stamey FR; Pau CP; Pellett PE; Spira TJ; Division of Viral and Rickettsial Diseases, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.
- Hypersensitivity syndrome associated with efavirenz therapy.
- Clin Infect Dis. 2000 Jan;30(1):227-8. Unique Identifier : AIDSLINE MED/20086575
- Bossi P; Colin D; Bricaire F; Caumes E; Department of Infectious Diseases, Hopital Pitie-Salpetriere,; 75651 Paris Cedex 13, France. philippe.bossi@psl.ap-hop-paris.fr
- Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy.
- Unique Identifier : AIDSLINE MED/20086577
- Jacobson MA; Stanley H; Holtzer C; Margolis TP; Cunningham ET; Department of Medicine University of California at San Francisco,
- Successful resolution of progressive multifocal leukoencephalopathy after combination therapy with cidofovir and cytosine arabinoside [letter]
- Clin Infect Dis. 2000 Jan;30(1):234. Unique Identifier : AIDSLINE MED/20086578
- Chocarro Martinez A; Gonzalez Lopez A; Garcia Garcia I
- Helminth infections in HIV-infected persons in the United States, 1990-1999 [letter]
- Clin Infect Dis. 2000 Jan;30(1):241-2. Unique Identifier : AIDSLINE MED/20086590
- McCombs SB; Dworkin MS; Wan PC
- Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups.
- Clin Infect Dis. 2000 Jan;30(1):47-54. Unique Identifier : AIDSLINE MED/20086535
- Graybill JR; Sobel J; Saag M; van Der Horst C; Powderly W; Cloud G; Riser L; Hamill R; Dismukes W; Infectious Diseases Section, South Texas Veterans Health Care; System, Audie L. Murphy Memorial Veterans Hospital Division, San; Antonio, TX 78284, USA. graybill@uthscsa.edu
- This study was undertaken to characterize the laboratory and clinical course of patients with AIDS and cryptococcal meningitis who had normal or elevated cerebrospinal fluid (CSF) pressure. Data were obtained retrospectively from a randomized multicenter quasifactorial phase III study comparing amphotericin B with or
- Sporotrichosis in Peru: description of an area of hyperendemicity.
- Clin Infect Dis. 2000 Jan;30(1):65-70. Unique Identifier : AIDSLINE MED/20086538
- Pappas PG; Tellez I; Deep AE; Nolasco D; Holgado W; Bustamante B; Division of Infectious Diseases, University of Alabama at; Birmingham School of Medicine, Birmingham, AL 35294-0006, USA.; ppappas@uabid. dom.uab.edu
- Sporotrichosis is a sporadic and rare mycotic infection in most of the developed world. In many parts of the developing world, sporotrichosis is much more commonly recognized, but epidemiological data are generally lacking from these regions. We report epidemiological, clinical, and treatment data from 238 cases of cu
- Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response.
- Clin Infect Dis. 2000 Jan;30(1):95-9. Unique Identifier : AIDSLINE MED/20086542
- Giudici B; Vaz B; Bossolasco S; Casari S; Brambilla AM; Luke W; Lazzarin A; Weber T; Cinque P; Division of Infectious Diseases, San Raffaele Hospital, 20127; Milano, Italy.
- Cerebrospinal fluid (CSF) samples were examined from 7 patients infected with human immunodeficiency virus type 1 (HIV-1) who had progressive multifocal leukoencephalopathy (PML). Samples were obtained both before and after 35-365 days of highly active antiretroviral therapy (HAART). By polymerase chain reaction, JC v
- Anti-Beta 2-glycoprotein I antibody isotype and IgG subclass in antiphospholipid syndrome patients.
- Autoimmunity. 1999 Oct;31(2):109-16. Unique Identifier : AIDSLINE MED/20142942
- Guerin J; Casey E; Feighery C; Jackson J; Department of Immunology, St. James's Hospital, Dublin, Ireland.
- Beta 2-glycoprotein I (beta2-GPI) is an antigenic target recognised by antiphospholipid antibodies found in association with the antiphospholipid syndrome (APS). In this study, the prevalence of Immunoglobulin M (IgM) and IgA anti-beta2-GPI antibodies was examined in APS patients and compared with IgG antibodies. In a
- Management protocol for abacavir-related hypersensitivity reaction.
- Ann Pharmacother. 2000 Feb;34(2):247-9. Unique Identifier : AIDSLINE MED/20140003
- Clay PG; Rathbun RC; Slater LN; Fellow of Infectious Diseases, College of Pharmacy, University of; Oklahoma, Oklahoma City, USA. pclay@cctr.umkc.edu
- OBJECTIVE: To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center. DATA SYNTHESIS: Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take w
- Oral sex may be important risk factor for HIV infection [news]
- BMJ. 2000 Feb 12;320(7232):400. Unique Identifier : AIDSLINE MED/20134462
- Gottlieb S
- Prospective investigation of transfusion transmitted infection in recipients of over 20 000 units of blood. TTI Study Group.
- BMJ. 2000 Feb 12;320(7232):403-6. Unique Identifier : AIDSLINE MED/20134471
- Regan FA; Hewitt P; Barbara JA; Contreras M; National Blood Service, London and South East Zone, North London; Centre, London NW9 5BG.
- OBJECTIVES: To follow up recipients of 20 000 units of blood to identify any transmissions of infections through blood transfusion. DESIGN: Follow up study of recipients of transfusion. SETTING: 22 hospitals in north London. PARTICIPANT: Adult patients who had recently been transfused. MAIN OUTCOME MEASURES: Patients
- Case management of the HIV/AIDS client.
- J Case Manag. 1998 Summer;7(2):62-6. Unique Identifier : AIDSLINE MED/20168014
- Kucera KA
- One of the most difficult issues a case manager has to deal with is how to stay knowledgeable and current in the face of rapidly changing medical advances. As treatment protocols for diseases change, so must the case management plans for clients. In the case of HIV/AIDS, this is especially true. This article examines
- Analysis of immunization with DNA encoding Pseudomonas aeruginosa exotoxin A.
- FEMS Immunol Med Microbiol. 2000 Feb;27(2):147-54. Unique Identifier : AIDSLINE MED/20108725
- Denis-Mize KS; Price BM; Baker NR; Galloway DR; Department of Microbiology, The Ohio State University, 484 West; 12th Avenue, Columbus, OH 43210-1292, USA.
- The promising arena of DNA-based vaccines has led us to investigate possible candidates for immunization against bacterial pathogens. One such target is the opportunistic pathogen Pseudomonas aeruginosa which produces exotoxin A (PE), a well-characterized virulence factor encoded by the toxA gene. In its native protei
- The redox pathway of S-nitrosoglutathione, glutathione and nitric oxide in cell to neuron communications.
- Free Radic Res. 1999 Dec;31(6):641-50. Unique Identifier : AIDSLINE MED/20094383
- Chiueh CC; Rauhala P; Unit on Neurodegeneration and Neuroprotection, Laboratory of; Clinical Science, National Institute of Mental Health, National; Institutes of Health, Bethesda, MD 20892-1264, USA.; chiueh@helix.nih.gov
- Recent results demonstrated that S-nitrosoglutathione (GSNO) and nitric oxide (*NO) protect brain dopamine neurons from hydroxyl radical (*OH)-induced oxidative stress in vivo because they are potent antioxidants. GSNO and *NO terminate oxidant stress in the brain by (i) inhibiting iron-stimulated hydroxyl radicals fo
- Newly approved abacavir to carry hypersensitivity warning [news]
- Am J Health Syst Pharm. 1999 Feb 15;56(4):304. Unique Identifier : AIDSLINE MED/20154801
- Miller JL
- Azithromycin-induced hearing loss.
- Am J Health Syst Pharm. 1999 Feb 15;56(4):380-3. Unique Identifier : AIDSLINE MED/20154810
- Lo SH; Kotabe S; Mitsunaga L; Laguna Honda Hospital, San Francisco, CA 94116, USA.
- Antibody to human endogenous retrovirus peptide in urine of human immunodeficiency virus type 1-positive patients.
- Clin Diagn Lab Immunol. 1999 Nov;6(6):783-6. Unique Identifier : AIDSLINE MED/20018381
- Stevens RW; Baltch AL; Smith RP; McCreedy BJ; Michelsen PB; Bopp LH; Urnovitz HB; Biomedical Resource Group, Albany, New York, USA.
- Human endogenous retrovirus (HERV)-like sequences are normal inherited elements that constitute several hundredths of the human genome. The expression of genes located within these elements can occur as a consequence of several different events, including persistent inflammation or genotoxic events. Antibodies to endo
- Enhanced secretory leukocyte protease inhibitor in human immunodeficiency virus type 1-infected patients.
- Clin Diagn Lab Immunol. 1999 Nov;6(6):808-11. Unique Identifier : AIDSLINE MED/20018386
- Baqui AA; Meiller TF; Falkler WA Jr; Department of Oral Medicine, Dental School, University of; Maryland, Baltimore, Maryland 21201, USA.; aab001@dental.umaryland.edu
- Secretory leukocyte protease inhibitor (SLPI) has been found to possess activity against the human immunodeficiency virus type 1 (HIV-1) in vitro at physiological concentrations. A study was undertaken to evaluate SLPI levels in human saliva and plasma among HIV-positive (HIV(+)) patients with various HIV-1 viral load
- Further characterization of human salivary anticandidal activities in a human immunodeficiency virus-positive cohort by use of microassays.
- Clin Diagn Lab Immunol. 1999 Nov;6(6):851-5. Unique Identifier : AIDSLINE MED/20018393
- Lin AL; Shi Q; Johnson DA; Patterson TF; Rinaldi MG; Yeh CK; Department of Dental Diagnostic Science, University of Texas; Health Science Center at San Antonio, San Antonio, Texas, USA.
- Salivary anticandidal activities play an important role in oral candidal infection. R. P. Santarpia et al. (Oral Microbiol. Immunol. 7:38-43, 1992) developed in vitro anticandidal assays to measure the ability of saliva to inhibit the viability of Candida albicans blastoconidia and the formation of germ tubes by C. al
- Regeneration and tolerance factor: a correlate of human immunodeficiency virus-associated T-cell activation.
- Clin Diagn Lab Immunol. 1999 Nov;6(6):872-7. Unique Identifier : AIDSLINE MED/20018397
- Givens TS; DuChateau BK; Boomer JS; Westerman MP; Gilman-Sachs A; Beaman KD; Clinical Immunology Laboratory and Department of; Microbiology/Immunology, Finch University of Health Sciences/The; Chicago Medical School, North Chicago, Illinois 60064, USA.
- Human immunodeficiency virus (HIV) infection causes extensive phenotypic alterations in lymphocytes. Cellular markers that are normally absent or expressed at low levels on quiescent cells are upregulated throughout the disease course. The transmembrane form of regeneration and tolerance factor (RTF) is expressed at n
- Genotyping of the CCR5 chemokine receptor by isothermal NASBA amplification and differential probe hybridization.
- Clin Diagn Lab Immunol. 1999 Nov;6(6):959-65. Unique Identifier : AIDSLINE MED/20018411
- Romano JW; Tetali S; Lee EM; Shurtliff RN; Wang XP; Pahwa S; Kaplan MH; Ginocchio CC; Advanced BioScience Laboratories, Inc., Kensington, Maryland; 20895, USA.
- The human CCR5 chemokine receptor functions as a coreceptor with CD4 for infection by macrophage-tropic isolates of human immunodeficiency virus type 1 (HIV-1). A mutated CCR5 allele which encodes a protein that does not function as a coreceptor for HIV-1 has been identified. Thus, expression of the wild-type and/or m
- Sterols of Pneumocystis carinii hominis organisms isolated from human lungs [published erratum appears in Clin Diagn Lab Immunol 2000 Jan;7(1):129]
- Clin Diagn Lab Immunol. 1999 Nov;6(6):970-6. Unique Identifier : AIDSLINE MED/20018413
- Kaneshiro ES; Amit Z; Chandra J; Baughman RP; Contini C; Lundgren B; Department of Biological Sciences, University of Cincinnati,; Cincinnati, Ohio 45221, USA. Edna.Kaneshiro@uc.edu
- The opportunistic pathogen Pneumocystis carinii causes pneumonia (P. carinii pneumonia, or PCP) in immunocompromised individuals such as AIDS patients. Rat-derived P. carinii carinii organisms have distinct sterols which are not synthesized by mammals and not found in other microbes infecting mammalian lungs. The domi
- Declining immunoglobulin A production in prostates of men with AIDS.
- Clin Diagn Lab Immunol. 1999 Nov;6(6):981-2. Unique Identifier : AIDSLINE MED/20018415
- Carson HJ; Lueck NE; Department of Pathology, Mercy Medical Center, Cedar Rapids, Iowa; 52403, USA. hjcmd@earthlink.net
- We studied immunoglobulin A production (IgA) in prostates of men with AIDS. Prostate sections from AIDS patients and human immunodeficiency virus-negative men were stained for IgA with immunoperoxidase. Prostate sections from nondiseased men were positive for IgA, while prostate sections from AIDS patients were essent
- Anti-tumour activity against B16-F10 melanoma with a GM-CSF secreting allogeneic tumour cell vaccine [published erratum appears in Gene Ther 1999 Nov;6(11):1905]
- Gene Ther. 1999 Aug;6(8):1475-81. Unique Identifier : AIDSLINE MED/99398761
- Kayaga J; Souberbielle BE; Sheikh N; Morrow WJ; Scott-Taylor T; Vile R; Chong H; Dalgleish AG; Department of Oncology, St George's Hospital Medical School,; London, UK.
- Genetic modification of tumour cells with the GM-CSF encoding gene renders these cells more potent, as autologous tumour cell vaccine, than their wild-type counterparts. However, autologous vaccines are impractical for wide-scale clinical use and we have therefore investigated the efficacy of the GM-CSF genetic modifi
- [Recent advances in the treatment the nervous system disorders with interferon-alpha]
- Rev Neurol. 1999 Dec 16-31;29(12):1225-35. Unique Identifier : AIDSLINE MED/20118345
- Cabrera-Gomez JA; Lopez-Saura P; Servicio de Neurologia, Hospital Provincial Dr. Gustavo; Aldereguia Lima, Cienfuegos, Cuba. cabrera@jagua.cfg.sld.cu
- INTRODUCTION: The interferons (IFN) have had considerable effect on the course of relapses and the natural course of the disability of patients with multiple sclerosis (MS). However, the effects of IFN in other neurological disorders are little known. OBJECTIVES: To review the literature on the experimental and clinic
- [Opsoclonus-myoclonus in a patient with AIDS: a good response to treatment with IV immunoglobulins (letter)]
- Rev Neurol. 1999 Dec 16-31;29(12):1346-8. Unique Identifier : AIDSLINE MED/20118363
- Garcia-Morales I; Porta-Etessam J; Saiz-Diaz R; Gomez-Escalonilla C; Galan L; Parrilla G; Molina JA
- [Tropical spastic paraparesis and mixed infection due to Treponema pallidum and HTLV-1 (letter)]
- Rev Neurol. 1999 Dec 16-31;29(12):1350-1. Unique Identifier : AIDSLINE MED/20118366
- Carod-Artal FJ
- Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation.
- RNA. 2000 Feb;6(2):170-7. Unique Identifier : AIDSLINE MED/20151064
- Ashe MP; Furger A; Proudfoot NJ; Sir William Dunn School of Pathology, University of Oxford,; United Kingdom.
- The inactivity or occlusion of the HIV-1 poly(A) signal when in the 5 long terminal repeat (LTR) has been mechanistically investigated. First we show that neither the homologous HIV-1 promoter nor the close proximity of this RNA processing signal to the transcript initiation site is required for the occlusion effect.
- Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP.
- RNA. 2000 Feb;6(2):178-88. Unique Identifier : AIDSLINE MED/20151065
- Vagner S; Ruegsegger U; Gunderson SI; Keller W; Mattaj IW; European Molecular Biology Laboratory, Heidelberg, Germany.
- The 3 ends of most eukaryotic pre-mRNAs are generated by 3 endonucleolytic cleavage and subsequent polyadenylation. 3 -end formation can be influenced positively or negatively by various factors. In particular, U1 snRNP acts as an inhibitor when bound to a 5 splice site located either upstream of the 3 -end formati
- The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure.
- RNA. 2000 Feb;6(2):282-95. Unique Identifier : AIDSLINE MED/20151074
- Berkhout B; van Wamel JL; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands. b.berkhout@amc.uva.nl
- The untranslated leader of the RNA genome of the human immunodeficiency virus type 1 (HIV-1) encodes multiple signals that regulate distinct steps of the viral replication cycle. The RNA secondary structure of several replicative signals in the HIV-1 leader is critical for function. Well-known examples include the TAR
- HIV/AIDS and infection control [letter]
- J Can Dent Assoc. 1999 Dec;65(11):603. Unique Identifier : AIDSLINE MED/20122846
- Hardie J
- The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine.
- Biol Chem. 1999 Dec;380(12):1383-94. Unique Identifier : AIDSLINE MED/20125507
- Fernandez PC; Machado J Jr; Heussler VT; Botteron C; Palmer GH; Dobbelaere DA; Laboratory of Molecular Pathology, Institute of Animal Pathology,; University of Berne, Switzerland.
- Nuclear factor-kappaB regulates genes that control immune and inflammatory responses and are involved in the pathogenesis of several diseases, including AIDS and cancer. It has been proposed that reactive oxygen intermediates participate in NF-kappaB activation pathways, and compounds with putative antioxidant activit
- Miscellaneous treatments: thalidomide, potassium iodide, levamisole, clofazimine, colchicine, and D-penicillamine.
- Clin Dermatol. 2000 Jan-Feb;18(1):131-45. Unique Identifier : AIDSLINE MED/20165922
- Sanchez MR; New York University School of Medicine, Ronald O. Perelman; Department of Dermatology, NY 10016, USA.
- Delays and continuation of hospital visits among HIV-infected persons and AIDS cases in Japan.
- J Epidemiol. 2000 Jan;10(1):65-70. Unique Identifier : AIDSLINE MED/20159586
- Hashimoto S; Matsumoto T; Nagai M; Matsuyama Y; Nakamura Y; Umeda T; Kamakura M; Ichikawa S; Kimura S; Fukutomi K; Kihara M; Department of Biostatistics/Epidemiology and Preventive Health; Sciences, School of Health Sciences and Nursing, University of; Tokyo, Japan.
- This study attempts to clarify the distribution patterns of delay between HIV transmission and the first hospital visit among HIV-infected persons and AIDS cases in Japan except those infected through blood products. Such hospital visit patterns were analyzed, and the rates of repor
- Training issues for supervisors of marriage and family therapists working with persons living with HIV.
- J Marital Fam Ther. 2000 Jan;26(1):103-11. Unique Identifier : AIDSLINE MED/20149617
- Serovich JM; Mosack KE; Department of Human Development and Family Science, Ohio State; University, Columbus 43210, USA. Serovich.1@osu.edu
- The purpose of this article is to address the special issues and considerations Martial and Family Therapy (MFT) supervisors might face with the increasing HIV/AIDS epidemic. Three primary issues will be addressed in this article. First, the importance of educating therapists regarding various aspects of the disease p
- Mechanism of impaired immunologic response to bacterial antigens in burn wounds in children.
- Pediatr Surg Int. 2000;16(1-2):85-8. Unique Identifier : AIDSLINE MED/20130980
- Andrzejewska E; Niewiadomska H; Nawrot E; Clinic of Paediatric and Oncological Surgery, Institute of; Paediatrics, Medical University of Lodz, Sporna 36/50, Lodz,; Poland 91-738.
- Material was obtained from necrotic tissue excised from burn wounds in 60 children and examined immunohistochemically for the percentages of CD3, CD4, CD8, CD20, and CD68 cells. The results were then correlated with the burn surface area (BSA). Bacteriologic studies revealed the presence of bacteria in only 22 wounds
- Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection.
- J Chromatogr B Biomed Sci Appl. 1999 Dec 24;736(1-2):123-8. Unique Identifier : AIDSLINE MED/20140161
- Veldkamp AI; Sparidans RW; Hoetelmans RM; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands. apabg@slz.nl
- Abacavir is a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infection. A simple and rapid high-performance liquid chromatographic method for the quantification of abacavir in human plasma suitable for pharmacokinetic rese
- Human polyomavirus BK (BKV) load and haemorrhagic cystitis in bone marrow transplantation patients.
- J Clin Virol. 1999 Oct;14(2):79-86. Unique Identifier : AIDSLINE MED/20053671
- Azzi A; Cesaro S; Laszlo D; Zakrzewska K; Ciappi S; De Santis R; Fanci R; Pesavento G; Calore E; Bosi A; Department of Public Health, University of Florence, Italy.; azzi@dsp.igiene.unifi.it
- Several observations suggest an association between long-lasting haemorrhagic cystitis (HC) in bone marrow transplantation (BMT) recipients and human polyomavirus BK (BKV) reactivation, but no conclusive evidence has been obtained so far. The amount of BKV measured in the urine of BMT patients during an episode of HC
- Comparison of three commercial assays for the quantification of HIV-1 RNA in plasma from individuals infected with different HIV-1 subtypes.
- J Clin Virol. 1999 Oct;14(2):87-94. Unique Identifier : AIDSLINE MED/20053672
- Chew CB; Herring BL; Zheng F; Browne C; Saksena NK; Cunningham AL; Dwyer DE; Department of Virology, CIDMLS, ICPMR, and Centre for Virus; Research, Westmead Millenium Institute, Westmead Hospital, NSW,; Australia.
- BACKGROUND: Commercial human immunodeficiency virus 1 (HIV-1) ribonucleic acid (RNA) quantification assays vary in their ability to quantify different subtypes of HIV-1, a problem in regions where multipte HIV-1 subtypes may be circulating. OBJECTIVES: To assess commercial HIV-1 RNA quantification assays on two plasma
- Visualisation of phenotypically mixed HIV-1 and HTLV-I virus particles by electron microscopy.
- J Biomed Sci. 2000 Jan-Feb;7(1):71-4. Unique Identifier : AIDSLINE MED/20113132
- Lawson VA; Lee JY; Doultree JC; Marshall JA; McPhee DA; AIDS Cellular Biology Unit, National Centre for HIV Virology; Research, Macfarlane Burnet Centre for Medical Research,; Fairfield, Australia. lawson@burnet.edu.au
- Virions produced after HIV-1 infection of HTLV-I transformed cells have an expanded tropism that has been attributed to the presence of HTLV-I glycoproteins in the envelope. This report now directly identifies these phenotypically mixed virions by immunogold labelling electron microscopy. Furthermore we estimate there
- [Gastroduodenal uptakes in the scans with 67Ga of the HIV infected patients studied for un-affiliated fever]
- Rev Esp Med Nucl. 1999 Oct;18(5):336-9. Unique Identifier : AIDSLINE MED/20032121
- del Val Gomez Mf; Gallardo F; Carbo J; Cobo J; Garcia-Samaniego J; Servicio de Medicina Nuclear, Hospital Carlos III, Madrid, 28029,; Espana.
- This work aimed to assess the significance of abnormal gastroduodenal uptake in the 67Ga scintigraphy of HIV patients who have been studied for fever of unknown origin. The examinations of 12 patients who had had a normal panedoscopy when the 67Ga scan was done, were selected. One out of 7 patients without gastroduode
- Histologic examination of bone marrow core biopsy specimens has limited value in the diagnosis of mycobacterial and fungal infections in patients with the acquired immunodeficiency syndrome.
- Ann Diagn Pathol. 2000 Feb;4(1):1-6. Unique Identifier : AIDSLINE MED/20149361
- Marques MB; Waites KB; Jaye DL; Kilby JM; Reddy VV; Departments of Pathology and Medicine, University of Alabama at; Birmingham, Birmingham, AL 35233-7331, USA.
- Bone marrow cultures and biopsy specimens are commonly obtained to rule out disseminated infections, especially in persons with the acquired immunodeficiency syndrome (AIDS) and cytopenias. Using culture as the gold standard, we reviewed 130 consecutive bone marrow cores obtained from 114 AIDS patients along with resu
- Plant-derived and semi-synthetic calanolide compounds with in vitro activity against both human immunodeficiency virus type 1 and human cytomegalovirus.
- Antivir Chem Chemother. 2000 Jan;11(1):23-9. Unique Identifier : AIDSLINE MED/20155318
- Xu ZQ; Kern ER; Westbrook L; Allen LB; Buckheit RW Jr; Tseng CK; Jenta T; Flavin MT; MediChem Research and Sarawak MediChem Pharmaceuticals, Lemont,; IL 60439, USA. zxu@mcr.medichem.com
- Plant-derived and semi-synthetic calanolide compounds with anti-human immunodeficiency virus type 1 (HIV-1) activity were tested for anti-human cytomegalovirus (HCMV) activity in both cytopathic effect inhibition and plaque reduction assays. The results indicated that the anti-HCMV
- Importance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudine.
- Antivir Chem Chemother. 2000 Jan;11(1):31-9. Unique Identifier : AIDSLINE MED/20155319
- Venkatachalam TK; D'Cruz OJ; Uckun FM; Drug Discovery Program, Department of Chemistry, Hughes; Institute, St Paul, MN 55113, USA.
- In a systematic search for developing a virucidal spermicide with potent anti-human immunodeficiency virus (HIV) and spermicidal activities, we synthesized and evaluated 14 phosphoramidate derivatives of 5-bromo-6-methoxy-zidovudine (PP-BMZ) with differing amino acid ester side chains and para substitutions on the phe
- TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity.
- Antivir Chem Chemother. 2000 Jan;11(1):61-9. Unique Identifier : AIDSLINE MED/20155322
- Chamorro C; De Clercq E; Balzarini J; Camarasa MJ; San-Felix A; Instituto de Quimica Medica (C.S.I.C.), Madrid, Spain.
- Novel analogues of the anti-HIV-1 lead compound [1-[2 ,5 -bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]th- ymine]- 3 -spiro-5 -(4 -amino-1 ,2 -oxathiole-2 ,2 -dioxide) (TSAO-T) bearing different amino acids at position N-3 of thymine were prepared and evaluated as inhibitors of HIV replication. The synthesis o
- Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors.
- Bioorg Med Chem Lett. 2000 Jan 17;10(2):193-5. Unique Identifier : AIDSLINE MED/20135664
- Corbett JW; Gearhart LA; Ko SS; Rodgers JD; Cordova BC; Klabe RM; Erickson-Viitanen SK; DuPont Pharmaceuticals Company, Experimental Station, Wilmington,; DE 19880-0500, USA. jeffrey.w.corbett@dupontpharma.com
- Benzothiadiazine non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV have been synthesized via a novel process to afford active inhibitors, with the most potent compound exhibiting an IC90 = 180 nM in a whole cell assay. The 2,2-dioxide-1H-2,1,3-benzothiadiazine ring system was constructed in one step from
- Could a nasal spray protect people against human immunodeficiency virus? [news]
- Bull World Health Organ. 1999;77(12):1017-8. Unique Identifier : AIDSLINE MED/20168378
- Iron metabolism and HIV infection: reciprocal interactions with potentially harmful consequences?
- Cell Biochem Funct. 1999 Dec;17(4):279-87. Unique Identifier : AIDSLINE MED/20056139
- Savarino A; Pescarmona GP; Boelaert JR; Departiment of Medical and Surgical Sciences, University of; Turin, Turin, Italy.
- Humans with advanced human immunodeficiency virus (HIV) infection present some evidence suggestive of iron accumulation. Ferritin concentrations increase with HIV disease progression, and iron accumulates in several tissues. Iron excess may exert negative effects in individuals with HIV. Indeed, iron accumulation seem
- A review of HIV/AIDS case management research.
- Care Manag J. 1999 Spring;1(2):105-13. Unique Identifier : AIDSLINE MED/20105805
- Chernesky RH; Graduate School of Social Service, Fordham University, New York,; NY 10023, USA.
- Published research on HIV/AIDS case management is reviewed. Twenty-five studies are placed within a conceptual framework that can be used to guide a research agenda. Unlike other case management fields, research in this field has not kept pace with the growth and development of HIV/AIDS case management. Reasons for th
- Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum.
- Comb Chem High Throughput Screen. 1999 Dec;2(6):319-25. Unique Identifier : AIDSLINE MED/20113144
- Baecher-Allan CM; Santora K; Sarantopoulos S; Den W; Sompuram SR; Sharon J; Cevallos AM; Bhat N; Ward H; Department of Pathology and Laboratory Medicine, Boston; University School of Medicine, Boston, MA, 02118, USA.
- We had developed a technology for creation of recombinant polyclonal antibody libraries, standardized perpetual mixtures of polyclonal whole antibodies for which the genes are available and can be altered as desired. We report here the first phase of generating a polyclonal antibody library to Cryptosporidium parvum,
- N-acetyl-cysteine in the therapy of HIV-positive patients.
- Curr Opin Clin Nutr Metab Care. 1999 Nov;2(6):493-8. Unique Identifier : AIDSLINE MED/20142147
- Droge W; Breitkreutz R; Division of Immunochemistry, Deutsches Krebforschungszentrum,; Heidelberg, Germany. w.droege@dkfz-heidelberg.de
- Randomly selected asymptomatic HIV-positive persons reveal, on average, a massive daily loss of sulphur, which appears to represent in first approximation the mean loss throughout the asymptomatic stage, and may explain the widely observed decrease in cyst(e)ine and glutathione levels. This sulphur loss is reasonably
- Nosocomial tuberculosis prevention measures among two groups of US hospitals, 1992 to 1996.
- Unique Identifier : AIDSLINE MED/20135789
- Manangan LP; Bennett CL; Tablan N; Simonds DN; Pugliese G; Collazo E; Jarvis WR
- OBJECTIVE: To compare trends in nosocomial tuberculosis (TB) prevention measures and health-care worker (HCW) tuberculin skin test (TST) conversion of hospitals with HIV-related Pneumocystis carinii pneumonia (PCP) patients and other US hospitals from 1992 through 1996. Design and setting: Surveys in 1992 and 1996 of
- Miliary coccidioidomycosis in the immunocompetent.
- Chest. 2000 Feb;117(2):404-9. Unique Identifier : AIDSLINE MED/20135793
- Arsura EL; Kilgore WB; Kern Medical Center, Department of Internal Medicine,; Bakersfield, CA, USA.
- BACKGROUND: Miliary coccidioidomycosis indicates hematogenous or lymphatic spread of Coccidioides immitis and is characterized by the development of multiple small granulomas throughout the lungs and other organs. Previous reports have suggested that this disorder oc
- Intrathoracic Kaposi's sarcoma in women with AIDS.
- Chest. 2000 Feb;117(2):410-4. Unique Identifier : AIDSLINE MED/20135794
- Haramati LB; Wong J; Department of Radiology, Albert Einstein College of Medicine,; Montefiore Medical Center and Jacobi Medical Center, Bronx, NY; 10467, USA. lharamati@aecom.yu.edu
- STUDY OBJECTIVE: To describe the radiographic features of intrathoracic Kaposi s sarcoma in women with AIDS. Subjects and methods: From 1987 to 1998, we identified seven women with biopsy-proven (n = 4) or autopsy-proven (n = 3) pulmonary Kaposi s sarcoma. Charts were reviewed for HIV risk factors, cutaneous and/or or
- Fine-needle aspiration of cytomegalovirus sialadenitis in a patient with acquired immunodeficiency syndrome: pitfalls of diff-quik staining.
- Diagn Cytopathol. 2000 Feb;22(2):101-3. Unique Identifier : AIDSLINE MED/20115410
- Santiago K; Rivera A; Cabaniss D; Dhurhar N; Moroz K; Department of Pathology and Laboratory Medicine, Tulane; University School of Medicine, New Orleans, LA 70112-2699, USA.
- A case of cytomegalovirus ( CMV ) sialadenitis in a patient with acquired immunodeficiency syndrome (AIDS) diagnosed by fine-needle aspiration biopsy (FNAB) is reported. Although a diagnosis of CMV sialadenitis can be establish
- Predictors of women's decision to ask new partners to use condoms to avoid HIV/AIDS in South Africa.
- Unique Identifier : AIDSLINE MED/20149576
- Kirigia JM; Muthuri LH
- OBJECTIVES: (i) to identify the key determinants of women s decision to ask a new partner to use condoms during sexual intercourse in order to reduce the probability of HIV infection. (ii) to estimate the impact of social, economic and educational
- Nutrition in the management of acquired immunodeficiency syndrome.
- East Afr Med J. 1999 Sep;76(9):507-9. Unique Identifier : AIDSLINE MED/20149582
- Thuita FM; Mirie W; Department of Community Health, College of Health Sciences,; University of Nairobi.
- OBJECTIVE: To highlight the influence of nutrition on the progress of HIV/AIDS and the role and importance of good nutrition in the management of the disease. STUDY SELECTION: The subject was selected because it is now recognised that nutritional care and support is an essential component of the health care plan and m
- A model of a gp120 V3 peptide in complex with an HIV-neutralizing antibody based on NMR and mutant cycle-derived constraints.
- Eur J Biochem. 2000 Feb;267(3):767-79. Unique Identifier : AIDSLINE MED/20117685
- Zvi A; Tugarinov V; Faiman GA; Horovitz A; Anglister J; Department of Structural Biology, The Weizmann Institute of; Science, Rehovot, Israel.
- The 0.5beta monoclonal antibody is a very potent strain-specific HIV-neutralizing antibody raised against gp120, the envelope glycoprotein of HIV-1. This antibody recognizes the V3 loop of gp120, which is a major neutralizing determinant of the virus. The antibody-peptide interactions, involving aromatic and negativel
- Intestinal protozoa in HIV-infected patients in Apulia, South Italy.
- Unique Identifier : AIDSLINE MED/20155849
- Brandonisio O; Maggi P; Panaro MA; Lisi S; Andriola A
- Type I interferons and the Th1/Th2 paradigm.
- Dev Comp Immunol. 1999 Oct-Dec;23(7-8):657-63. Unique Identifier : AIDSLINE MED/20043995
- Sinigaglia F; D'Ambrosio D; Rogge L; Roche Milano Ricerche, Italy. francesco.sinigaglia@roche.com
- During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4+ T helper cell subsets. These have been driven, in part, by the realization that cytokines from the innate immune response, such as interleukin-12 (IL-12) and interferons (IFNs), play
- The promise of public/private sector collaboration in the development of vaginal microbicides.
- Int J Gynaecol Obstet. 1999 Dec;67 Suppl 2:S31-8. Unique Identifier : AIDSLINE MED/20125381
- Gabelnick HL; Harper MJ; CONRAD Program, Arlington, VA, USA.
- This paper describes the efforts of the public sector, primarily the CONRAD Program and its Consortium for Industrial Collaboration in Contraceptive Research (CICCR), to work with industry in the development of vaginal microbicides for the prevention of transmission of STDs including HIV. The results of a meeting on t
- Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection.
- Gut. 2000 Feb;46(2):260-9. Unique Identifier : AIDSLINE MED/20111149
- McGuinness PH; Painter D; Davies S; McCaughan GW; The A W Morrow Gastroenterology and Liver Centre, Royal Prince; Alfred Hospital, Camperdown, Australia.
- BACKGROUND: Upregulation of Th1 associated intrahepatic cytokines in chronic hepatitis C virus (HCV) infection should lead to a significant non-specific cellular immune response, a prerequisite for viral clearance. However, to date, the role of this non-specific response in HCV has been understudied. AIMS: To analyse
- Immunoprecipitation against exogenous antigens in the zone of alpha-1, alpha-2 and beta-globulins--a new immune phenomenon?
- Folia Med (Plovdiv). 1999;41(3):26-33. Unique Identifier : AIDSLINE MED/20122824
- Zlatev S; Zlateva D; Zhabilov H; Zhabilova J; Department of Microbiology and Immunology, Higher Medical; Institute, Plovdiv, Bulgaria.
- According to data by H. Zhabilov serum fractions in the zone of alpha 1, alpha 2 and beta-globulins from healthy people form a characteristic precipitation curve in terms of structure and density with the TNP (thymus nuclear protein) and CNP (carcinoma nuclear protein) as antigens when tested in two-dimensional agaros
- Unusual bone marrow manifestations of parvovirus B19 infection in immunocompromised patients.
- Hum Pathol. 2000 Feb;31(2):161-8. Unique Identifier : AIDSLINE MED/20148065
- Crook TW; Rogers BB; McFarland RD; Kroft SH; Muretto P; Hernandez JA; Latimer MJ; McKenna RW; Department of Pathology, University of Texas Southwestern Medical; Center, Dallas 75235-9072, USA.
- Parvovirus B19 is responsible for a spectrum of disease in humans. The usual bone marrow findings in acute parvovirus infections are marked erythroid hypoplasia and occasional giant erythroblasts. Intranuclear inclusions in developing erythroid precursors are rarely described in children or adults with parvovirus infe
- Raman Viswanathan Memorial Lecture. Host response in tuberculosis.
- Indian J Chest Dis Allied Sci. 1999 Oct-Dec;41(4):195-200. Unique Identifier : AIDSLINE MED/20126849
- Singh MM
- Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1 ) product.
- Immunogenetics. 2000 Feb;51(2):99-107. Unique Identifier : AIDSLINE MED/20130143
- Oka Y; Elisseeva OA; Tsuboi A; Ogawa H; Tamaki H; Li H; Oji Y; Kim EH; Soma T; Asada M; Ueda K; Maruya E; Saji H; Kishimoto T; Udaka K; Sugiyama H; Department of Molecular Medicine, Osaka University Medical; School, 2-2, Yamada-Oka, Suita City, Osaka 565-0871, Japan.
- The product of the Wilms tumor gene WT1 is a transcription factor overexpressed not only in leukemic blast cells of almost all patients with acute myeloid leukemia, acute lymphoid leukemia, and chronic myeloid leukemia, but also in various types of solid tumor cells. Thus, it is suggested that the WT1 gene plays an i
- Evaluation of adult T-cell leukemia/lymphoma incidence and its impact on non-Hodgkin lymphoma incidence in southwestern Japan.
- Int J Cancer. 2000 Feb 1;85(3):319-24. Unique Identifier : AIDSLINE MED/20121907
- Arisawa K; Soda M; Endo S; Kurokawa K; Katamine S; Shimokawa I; Koba T; Takahashi T; Saito H; Doi H; Shirahama S; Department of Preventive Medicine and Health Promotion, Nagasaki; University School of Medicine, Japan.; k-iwata@net.nagasaki-u.ac.jp
- The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is endemic. The first study area comprised 4 towns located
- [Allergen-specific immunotherapy (hyposensitization). Part 1. Basics and subcutaneous application]
- HNO. 2000 Jan;48(1):59-67. Unique Identifier : AIDSLINE MED/20130091
- Klimek L; Universitats-HNO-Klinik Mainz.
- Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy.
- J Clin Endocrinol Metab. 2000 Feb;85(2):776-80. Unique Identifier : AIDSLINE MED/20152749
- Aniszewski JP; Valyasevi RW; Bahn RS; Division of Endocrinology, Mayo Clinic/Foundation, Rochester,; Minnesota 55905, USA.
- We sought to determine whether the predominant orbital T helper (T(H)) cell subset in orbital T cell clones established from patients with Graves ophthalmopathy (GO) might be related to disease duration. A total of 117 clones were established from orbital adipose/connective tissues of 6 GO patients, and cytokine prod
- Effects of immunosuppression and disease severity upon neuropsychological function in HIV infection.
- Unique Identifier : AIDSLINE MED/20119389
- Basso MR; Bornstein RA; University of Tulsa, OK 74104, USA. michael-basso@utulsa.edu
- Effects of immunosuppression and illness severity upon neuropsychological function were assessed in a group of homosexual men with AIDS across 6 months. Participants included 62 who were seronegative (HIV-), 74 asymptomatic seropositives (HIV+A), 31 symptomatic seropositives (HIV+S), 23 with AIDS defining illnesses (A
- Dual task performance in HIV-1 infection.
- J Clin Exp Neuropsychol. 2000 Feb;22(1):16-24. Unique Identifier : AIDSLINE MED/20119382
- Hinkin CH; Castellon SA; Hardy DJ; Department of Psychiatry and Biobehavioral Sciences, UCLA School; of Medicine, CA 90024, USA. chinkin@ucla.edu
- Fifty HIV-infected individuals and 20 uninfected controls participated in an investigation of dual task performance in HIV-1 infection. Participants first engaged in a simple auditory reaction time (RT) task followed by a visual choice RT task (single task condition), and then they simultaneously engaged in both tasks
- IFN-beta modulates specific T cell responses in vitro but does not affect Experimental Autoimmune Encephalomyelitis in the SJL mouse.
- J Neuroimmunol. 1999 Dec;100(1-2):190-6. Unique Identifier : AIDSLINE MED/20158276
- Luca ME; Visser L; Lucas CJ; Nagelkerken L; Division of Immunological and Infectious Diseases, TNO Prevention; and Health, Leiden, Netherlands. me.luca@pg.tno.nl
- In this study, mouse recombinant IFN-beta was shown to favor PLP139-151-specific Th2 responses in vitro, by inhibiting IFN-gamma production and stimulating IL-4 and IL-10 production. IFN-beta (5000 U/day) failed to prevent the development or severity of EAE induced with PLP139-151. Whereas efficacy of IL-10 was found
- Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 bias.
- J Neuroimmunol. 1999 Dec;100(1-2):64-73. Unique Identifier : AIDSLINE MED/20158264
- Charles PC; Weber KS; Cipriani B; Brosnan CF; Department of Pathology, Albert Einstein College of Medicine,; Bronx, NY 10461, USA.
- The resistance or susceptibility of inbred strains of mice to various pathogens and autoimmune diseases such as EAE has been linked to differences in the balance between cytokines associated with Th1- and Th2-type immune responses. Previous work from this laboratory on the mouse strain specific resistance to mouse ade
- Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation.
- J Immunol. 2000 Feb 15;164(4):1658-62. Unique Identifier : AIDSLINE MED/20126022
- Chan OT; Shlomchik MJ; Section of Immunobiology, Department of Laboratory Medicine, Yale; University School of Medicine, New Haven, CT 06520, USA.
- Spontaneous CD8+ T cell activation in MRL-Faslpr mice is B cell dependent. It is unclear whether this B-dependent activation is mediated by direct Ag presentation via MHC class I proteins (i.e., cross-presentation) or whether activation occurs by an indirect mechanism, e.g., via effects on CD4+ cells. To determine how
- Adenoviral-mediated overexpression of monocyte chemoattractant protein-1 differentially alters the development of Th1 and Th2 type responses in vivo.
- J Immunol. 2000 Feb 15;164(4):1699-704. Unique Identifier : AIDSLINE MED/20126028
- Matsukawa A; Lukacs NW; Standiford TJ; Chensue SW; Kunkel SL; Department of Pathology, Division of Pulmonary Medicine,; University of Michigan Medical School, Ann Arbor, MI 48109, USA.
- The expression of chemokines during an immune response may participate in determining the intensity and type of the developing immune response. In the present study, we have examined the effect of overexpressing monocyte chemoattractant protein (MCP)-1 at the site of immunization during different stages of Th1- and Th
- Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells.
- J Immunol. 2000 Feb 15;164(4):1705-12. Unique Identifier : AIDSLINE MED/20126029
- Aloisi F; De Simone R; Columba-Cabezas S; Penna G; Adorini L; Laboratory of Organ Pathophysiology, Istituto Superiore di; Sanita, Rome, Italy.
- A precise knowledge of the early events inducing maturation of resting microglia into a competent APC may help to understand the involvement of this cell type in the development of CNS immunopathology. To elucidate whether signals from preactivated T cells are sufficient to induce APC features in resting microglia, mi
- Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells.
- J Immunol. 2000 Feb 15;164(4):1753-60. Unique Identifier : AIDSLINE MED/20126036
- Servet-Delprat C; Vidalain PO; Bausinger H; Manie S; Le Deist F; Azocar O; Hanau D; Fischer A; Rabourdin-Combe C; Immunobiologie Fondamentale et Clinique, Institut National de la; Sante et de la Recherche Medicale U503, Ecole Normale; Superieur Lyon, Lyon, France.
- Measles virus (MV) infection induces a profound immunosuppression responsible for a high rate of mortality in malnourished children. MV can encounter human dendritic cells (DCs) in the respiratory mucosa or in the secondary lymphoid organs. The purpose of this study was to investigate the consequences of DC infection
- Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes.
- J Immunol. 2000 Feb 15;164(4):1768-74. Unique Identifier : AIDSLINE MED/20126038
- Franchimont D; Galon J; Gadina M; Visconti R; Zhou Y; Aringer M; Frucht DM; Chrousos GP; O'Shea JJ; Lymphocyte Cell Biology Section, National Institute of Arthritis; and Musculoskeletal and Skin Diseases, National Institutes of; Health, Bethesda, MD 20892, USA.
- Glucocorticoids are widely used in the therapy of inflammatory, autoimmune, and allergic diseases. As the end-effectors of the hypothalamic-pituitary-adrenal axis, endogenous glucocorticoids also play an important role in suppressing innate and cellular immune responses. Previous studies have indicated that glucocorti
- Ly49I NK cell receptor transgene inhibition of rejection of H2b mouse bone marrow transplants.
- J Immunol. 2000 Feb 15;164(4):1793-9. Unique Identifier : AIDSLINE MED/20126041
- Liu J; Morris MA; Nguyen P; George TC; Koulich E; Lai WC; Schatzle JD; Kumar V; Bennett M; Department of Pathology, Laboratory of Molecular Pathology,; Graduate Program in Immunology, University of Texas Southwestern; Medical Center, Dallas, TX 75235, USA.
- The Ly49 family of genes encode NK cell receptors that bind class I MHC Ags and transmit negative signals if the cytoplasmic domains have immunoregulatory tyrosine-based inhibitory motifs (ITIMs). 5E6 mAbs recognize Ly49C and Ly49I receptors and depletion of 5E6+ NK cells prevents rejection of allogeneic or parental-s
- The balance of protein kinase C and calcium signaling directs T cell subset development.
- J Immunol. 2000 Feb 15;164(4):1807-13. Unique Identifier : AIDSLINE MED/20126043
- Noble A; Truman JP; Vyas B; Vukmanovic-Stejic M; Hirst WJ; Kemeny DM; Department of Immunology, Guy's, King's, and St. Thomas' School; of Medicine, Rayne Institute, London, United Kingdom.; alistair.noble@kcl.ac.uk
- Development of naive T cells into type 1 (Th1, Tc1) or type 2 (Th2, Tc2) effector cells is thought to be under the control of cytokines. In this study, we show that when both IL-12 and IL-4 are present, murine and human T cell differentiation is regulated by the balance of protein kinase C (PKC) and calcium signaling
- Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity.
- J Immunol. 2000 Feb 15;164(4):1862-72. Unique Identifier : AIDSLINE MED/20126050
- Karulin AY; Hesse MD; Tary-Lehmann M; Lehmann PV; Department of Pathology, Case Western Reserve University,; Cleveland, OH 44106, USA.
- The patterns of Ag-induced cytokine coexpression in normal, in vivo-primed CD4 memory T cells has remained controversial because the low frequency at which these cells occur has effectively prevented direct ex vivo measurements. We have overcome this limitation by using two-color cytokine enzyme-linked immunospot assa
- Intestinal intraepithelial lymphocytes exert potent protective cytotoxic activity during an acute virus infection.
- J Immunol. 2000 Feb 15;164(4):1986-94. Unique Identifier : AIDSLINE MED/20126064
- Muller S; Buhler-Jungo M; Mueller C; Institute of Pathology, Division of Immunopathology, University; of Bern, Bern, Switzerland.
- After systemic infection of mice with 104 PFU of lymphocytic choriomeningitis virus (LCMV), infected cells are detected simultaneously in various organs, including spleen and intestinal mucosa. Most notably, virus-infected cells are also present among CD11c+ dendritic cells in the subepithelial area of the small intes
- NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells.
- J Immunol. 2000 Feb 15;164(4):2009-15. Unique Identifier : AIDSLINE MED/20126067
- Slifka MK; Pagarigan RR; Whitton JL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA. mslifka@scripps.edu
- NK cells have been phenotypically defined by the expression of specific markers such as NK1.1, DX5, and asialo-GM1 (ASGM1). In addition to NK cells, a small population of CD3+ T cells has been shown to express these markers, and a unique subpopulation of NK1. 1+CD3+ T cells that expresses an invariant TCR has been nam
- CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection.
- J Immunol. 2000 Feb 15;164(4):2021-7. Unique Identifier : AIDSLINE MED/20126069
- Traynor TR; Kuziel WA; Toews GB; Huffnagle GB; Pulmonary Division, Department of Internal Medicine, University; of Michigan, Ann Arbor, MI 48109, USA.
- Pulmonary clearance of the encapsulated yeast Cryptococcus neoformans requires the development of T1-type immunity. The objective of this study was to determine the role of CCR2 in leukocyte recruitment and development of T1-type cell-mediated immunity during pulmonary C. neoformans infection. Intratracheal inoculatio
- Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism.
- J Immunol. 2000 Feb 15;164(4):2046-52. Unique Identifier : AIDSLINE MED/20126072
- Urban JF Jr; Schopf L; Morris SC; Orekhova T; Madden KB; Betts CJ; Gamble HR; Byrd C; Donaldson D; Else K; Finkelman FD; U.S. Department of Agriculture, Beltsville, MD, 20705, USA.
- Studies in mice infected with the gastrointestinal nematode parasite Nippostrongylus brasiliensis demonstrated that IL-4/IL-13 activation of Stat6 suppresses development of intestinal mastocytosis and does not contribute to IL-4/IL-13 production, but is still essential for parasite expulsion. Because expulsion of anot
- Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease.
- J Immunol. 2000 Feb 15;164(4):2102-9. Unique Identifier : AIDSLINE MED/20126079
- Kawai T; Eisen-Lev R; Seki M; Eastcott JW; Wilson ME; Taubman MA; Department of Immunology, The Forsyth Institute, Boston, MA; 02115, USA.
- The CD28 costimulation at TCR signaling plays a pivotal role in the regulation of the T cell response. To elucidate the role of T cells in periodontal disease, a system of cell transfer with TCR/CD28-dependent Th1 or Th2 clones was developed in rats. Gingival injection of specific Ag, Actinobacillus actinomycetemcomit
- Resection of solid tumors reverses T cell defects and restores protective immunity.
- J Immunol. 2000 Feb 15;164(4):2214-20. Unique Identifier : AIDSLINE MED/20126092
- Salvadori S; Martinelli G; Zier K; Division of Clinical Immunology, Department of Surgery, Mount; Sinai School of Medicine, New York, NY 10029, USA.
- We have previously reported that CTL were demonstrable early after inoculation of CMS5 fibrosarcoma cells, but that they disappeared within 3 wk. These mice were unable to reject a challenge with CMS5 tumor cells. Other studies demonstrated cell surface phenotype and signaling abnormalities of cells within the spleen.
- Clonotype analysis of human alloreactive T cells: a novel approach to studying peripheral tolerance in a transplant recipient.
- Unique Identifier : AIDSLINE MED/20126095
- Kusaka S; Grailer AP; Fechner JH Jr; Jankowska-Gan E; Oberley T; Sollinger HW; Burlingham WJ
- The recognition of allo-MHC and associated peptides on the surface of graft-derived APC by host T cells (direct pathway allorecognition) plays an important role in acute rejection after organ transplantation. However, the status of the direct pathway T cells in stable long term transplants remains unclear. To
- Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides.
- J Invest Dermatol. 2000 Jan;114(1):117-21. Unique Identifier : AIDSLINE MED/20087068
- Fraser-Andrews EA; Woolford AJ; Russell-Jones R; Seed PT; Whittaker SJ; Skin Tumour Unit, St. John's Institute of Dermatology, United; Medical and Dental School of Guy's and St. Thomas's Hospital,; London, UK. e.fraser-andrews@umds.ac.uk
- T cell receptor gene analysis is a sensitive method for assessment of peripheral blood involvement in mycosis fungoides. This study uses polymerase chain reaction/single-strand conformational polymorphism (PCR/SSCP) analysis of the T cell receptor gamma gene and relates the results to skin stage and outcome in mycosis
- Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping.
- J Infect Dis. 2000 Jan;181(1):107-20. Unique Identifier : AIDSLINE MED/20087004
- Soudeyns H; Champagne P; Holloway CL; Silvestri GU; Ringuette N; Samson J; Lapointe N; Sekaly RP; Laboratoire d'Immunologie, Institut de Recherches Cliniques de; Montreal, McGill University, Montreal, Canada.; hsoudeyns@justine.umontreal.ca
- T cell receptor (TCR) repertoire perturbations are commonly detected in CD8+ T cells during adult primary human immunodeficiency virus (HIV) infection and have been associated with HIV-specific cytotoxic T cell responses. By use of flow cytometry, transient high-level TCR beta-chain variable region-specific expansions
- Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection.
- J Infect Dis. 2000 Jan;181(1):121-31. Unique Identifier : AIDSLINE MED/20087005
- Malhotra U; Berrey MM; Huang Y; Markee J; Brown DJ; Ap S; Musey L; Schacker T; Corey L; McElrath MJ; Department of Medicine, University of Washington, Fred Hutchinson; Cancer Research Center, Seattle, Washington, USA.
- T-cell responses were evaluated prospectively in 41 patients with acute human immunodeficiency virus type 1 (HIV-1) infection (30 untreated and 11 receiving zidovudine, lamivudine, and indinavir ) and in 38 uninfected adults. By 6-12 months, treated pa
- Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection.
- J Infect Dis. 2000 Jan;181(1):132-40. Unique Identifier : AIDSLINE MED/20087006
- Carl S; Daniels R; Iafrate AJ; Easterbrook P; Greenough TC; Skowronski J; Kirchhoff F; Institute for Clinical Virology, University of; Erlangen-Nurnberg, Erlangen, Germany.
- A 36-bp deletion close to the 5 end of NEF that impaired Nef function was found in a long-term nonprogressor with human immunodeficiency virus type 1 (HIV-1) infection. Forms containing an adjacent duplication of 33 bp were also frequently observed. The duplication showed no homology to the deleted region but restore
- Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy.
- J Infect Dis. 2000 Jan;181(1):141-7. Unique Identifier : AIDSLINE MED/20087007
- Smith KY; Valdez H; Landay A; Spritzler J; Kessler HA; Connick E; Kuritzkes D; Gross B; Francis I; McCune JM; Lederman MM; Section of Infectious Diseases, Rush Presbyterian-St. Luke's; Medical Center, Chicago, IL 60612, USA. ksmith2@rush.edu
- Human immunodeficiency virus (HIV) infection is associated with progressive loss of circulating CD4+ lymphocytes. Treatment with highly active antiretroviral therapy (HAART) has led to increases in CD4+ T lymphocytes of naive (CD45RA+62L+) and memory (CD45R0+RA-) phenotypes. Thymic computerized tomography scans were o
- Reduced mobilization of CD34+ stem cells in advanced human immunodeficiency virus type 1 disease.
- J Infect Dis. 2000 Jan;181(1):148-57. Unique Identifier : AIDSLINE MED/20087008
- Schooley RT; Mladenovic J; Sevin A; Chiu S; Miles SA; Pomerantz RJ; Campbell TB; Bell D; Ambruso D; Wong R; Landay A; Coombs RW; Fox L; Kamoun M; Jacovini J; University of Colorado Health Sciences Center, Division of; Infectious Diseases, Denver, CO 80262, USA.; Robert.Schooley@uchsc.edu
- Granulocyte colony-stimulating factor (r-met Hu G-CSF; filgrastim; 10 microgram/kg/day for 7 days) was used to mobilize CD34+stem cells into the peripheral blood of human immunodeficiency virus type 1 (HIV-1)-infected individuals and a group of HIV-1-uninfected donors as a measure of immunologic reserve in HIV-1-infec
- Risk factors for community-acquired pneumonia among persons infected with human immunodeficiency virus.
- J Infect Dis. 2000 Jan;181(1):158-64. Unique Identifier : AIDSLINE MED/20087009
- Navin TR; Rimland D; Lennox JL; Jernigan J; Cetron M; Hightower A; Roberts JM; Kaplan JE; Division of Parasitic Diseases, Centers for Disease Control and; Prevention, Atlanta, GA 30341, USA. trn1@cdc.gov
- Two hundred eleven adults with human immunodeficiency virus (HIV) infection hospitalized for community-acquired pneumonia, including Pneumocystis carinii pneumonia (PCP; patients), and 192 matched HIV-infected hospitalized patients without pneumonia (controls) were interviewed to determine risk factors for pneumonia.
- High frequency of cytomegalovirus-specific cytotoxic T-effector cells in HLA-A*0201-positive subjects during multiple viral coinfections.
- J Infect Dis. 2000 Jan;181(1):165-75. Unique Identifier : AIDSLINE MED/20087010
- Jin X; Demoitie MA; Donahoe SM; Ogg GS; Bonhoeffer S; Kakimoto WM; Gillespie G; Moss PA; Dyer W; Kurilla MG; Riddell SR; Downie J; Sullivan JS; McMichael AJ; Workman C; Nixon DF; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York, USA.
- How the cellular immune response copes with diverse antigenic competition is poorly understood. Responses of virus-specific cytotoxic T lymphocytes (CTL) were examined longitudinally in an individual coinfected with human immunodeficiency virus type 1 (HIV-1), Epstein-Barr virus (EBV), and
- Virulent Treponema pallidum, lipoprotein, and synthetic lipopeptides induce CCR5 on human monocytes and enhance their susceptibility to infection by human immunodeficiency virus type 1.
- J Infect Dis. 2000 Jan;181(1):283-93. Unique Identifier : AIDSLINE MED/20087024
- Sellati TJ; Wilkinson DA; Sheffield JS; Koup RA; Radolf JD; Norgard MV; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas, Texas, USA.
- Treponema pallidum, its membrane lipoproteins, and synthetic lipoprotein analogues (lipopeptides) were each examined to determine whether they induced CCR5 expression on human peripheral blood mononuclear cells (PBMC). Reverse transcription-polymerase chain reaction for CCR5 gene transcripts, macrophage inflammatory p
- A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan.
- J Infect Dis. 2000 Jan;181(1):35-41. Unique Identifier : AIDSLINE MED/20086995
- Boschi-Pinto C; Stuver S; Okayama A; Trichopoulos D; Orav EJ; Tsubouchi H; Mueller N; Oswaldo Cruz Foundation and Fluminense Federal University, Rio de; Janeiro, Brazil.
- A follow-up study was performed to analyze the effects of hepatitis C virus (HCV) infection on morbidity and mortality in the adult population from a village in Japan found to have endemic levels of both HCV and human T lymphotropic virus type I (HTLV-I). By use of the Cox proportio
- Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy.
- J Infect Dis. 2000 Jan;181(1):354-7. Unique Identifier : AIDSLINE MED/20087035
- Schacker T; Little S; Connick E; Gebhard-Mitchell K; Zhang ZQ; Krieger J; Pryor J; Havlir D; Wong JK; Richman D; Corey L; Haase AT; Department of Medicine/Infectious Diseases, University of; Minnesota, 216 Delaware St., Minneapolis, MN 55455, USA.; schacker@lenti.med.umn.edu
- The follicular dendritic cell network (FDC) in lymphoid tissues (LTs) is the major site of human immunodeficiency virus (HIV) storage in presymptomatic and late stages of disease. However, little is known about the rate of virus accumulation during the acute and early stages. In situ hybridization and quantitative ima
- Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response.
- J Infect Dis. 2000 Jan;181(1):358-63. Unique Identifier : AIDSLINE MED/20087036
- Connick E; Lederman MM; Kotzin BL; Spritzler J; Kuritzkes DR; St Clair M; Sevin AD; Fox L; Chiozzi MH; Leonard JM; Rousseau F; D'Arc Roe J; Martinez A; Kessler H; Landay A; University of Colorado Health Sciences Center, Box B168, 4200 E.; Ninth Ave., Denver, CO 80220, USA. liz.connick@uchsc.edu
- The effects of 1 year of zidovudine, lamivudine, and ritonavir treatment on immune reconstitution were evaluated in 34 human immunodeficiency virus (HIV)-infected individuals. After 48 weeks of therapy, 20 (59%) subjects had
- Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo.
- J Infect Dis. 2000 Jan;181(1):390-4. Unique Identifier : AIDSLINE MED/20087042
- Kedzierska K; Mak J; Mijch A; Cooke I; Rainbird M; Roberts S; Paukovics G; Jolley D; Lopez A; Crowe SM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre, and; National Centre for HIV Virology Research, Fairfield, Australia.
- The role of human immunodeficiency virus type 1 (HIV-1) infection on the ability of human monocytes/macrophages to phagocytose Mycobacterium avium complex (MAC) in vivo and in vitro and the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on this function were investigated. By use of a flow cytometr
- Safety and immune responses to a DNA-based human immunodeficiency virus (HIV) type I env/rev vaccine in HIV-infected recipients: follow-up data [letter]
- J Infect Dis. 2000 Jan;181(1):406. Unique Identifier : AIDSLINE MED/20087047
- MacGregor RR; Boyer JD; Ciccarelli RB; Ginsberg RS; Weiner DB
- The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients.
- J Infect Dis. 2000 Jan;181(1):51-7. Unique Identifier : AIDSLINE MED/20086997
- Nordoy I; Muller F; Nordal KP; Rollag H; Lien E; Aukrust P; Froland SS; Section of Clinical Immunology, Research Institute of Internal; Medicine, Medical Dept., Rikshospitalet, N-0027 Oslo, Norway.; ingvild.nordoy@klinmed.uio.no
- The effects of cytomegalovirus ( CMV ) infection on monocyte and T cell activation and the role of the tumor necrosis factor (TNF) system and interleukin (IL)-10 were studied in a prospective study of 25 renal transplant recipi
- Cervical shedding of herpes simplex virus in human immunodeficiency virus-infected women: effects of hormonal contraception, pregnancy, and vitamin A deficiency.
- J Infect Dis. 2000 Jan;181(1):58-63. Unique Identifier : AIDSLINE MED/20086998
- Mostad SB; Kreiss JK; Ryncarz AJ; Mandaliya K; Chohan B; Ndinya-Achola J; Bwayo JJ; Corey L; International AIDS Research and Training Program, Department of; Epidemiology, University of Washington, Seattle, Washington; 98195, USA.
- Genital shedding of herpes simplex virus (HSV) results in frequent transmission of infection to sexual partners and neonates. In a cross-sectional study, cervical shedding of HSV DNA was detected in 43 (17%) cervical swab samples from 273 women seropositive for HSV-1, HSV-2, and human immunodeficiency virus type 1 (HI
- Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: correlation of T cell apoptosis with beta2 microglobulin concentration and disease evolution.
- J Infect Dis. 2000 Jan;181(1):64-75. Unique Identifier : AIDSLINE MED/20086999
- Michel P; Balde AT; Roussilhon C; Aribot G; Sarthou JL; Gougeon ML; Institut Pasteur, Dakar, Senegal, West Africa.
- This study analyzes the degree of immune activation and characterizes apoptosis in lymphocytes from healthy West African donors or patients infected with human immunodeficiency virus (HIV)-1 or -2. The lower decline of CD4 T cells in HIV-2- compared with HIV-1-infected donors is associated with lower levels of immune
- Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus type 1 subtype C in Southern Africa is associated with an NF-kappaB enhancer gain-of-function.
- J Infect Dis. 2000 Jan;181(1):76-81. Unique Identifier : AIDSLINE MED/20087000
- Montano MA; Nixon CP; Ndung'u T; Bussmann H; Novitsky VA; Dickman D; Essex M; Department of Immunology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.
- The human immunodeficiency virus type 1 (HIV-1) epidemic within southern Africa is predominantly associated with the HIV-1C subtype. Functional analysis of the enhancer region within the long terminal repeat (LTR) indicates that HIV-1C isolates have >/=3 NF-kappaB binding sites, unlike other subtypes, which have only
- Impact of the ovulatory cycle on virologic and immunologic markers in HIV-infected women.
- J Infect Dis. 2000 Jan;181(1):82-90. Unique Identifier : AIDSLINE MED/20087001
- Greenblatt RM; Ameli N; Grant RM; Bacchetti P; Taylor RN; University of California, Infectious Diseases Division, San; Francisco, CA 94122, USA. ruthg@itsa.ucsf.edu ruthg@itsa.ucsf.edu
- An individual s sex influences plasma human immunodeficiency virus type 1 (HIV-1) RNA level and rate of CD4 cell decline, but the mechanism for this effect is currently unknown. To determine the effect of the ovulatory cycle on HIV-1 RNA level and lymphocyte subsets in HIV-infected women, blood specimens were obtained
- Epidemic transmission of human immunodeficiency virus in renal dialysis centers in Egypt.
- J Infect Dis. 2000 Jan;181(1):91-7. Unique Identifier : AIDSLINE MED/20087002
- El Sayed NM; Gomatos PJ; Beck-Sague CM; Dietrich U; von Briesen H; Osmanov S; Esparza J; Arthur RR; Wahdan MH; Jarvis WR; National AIDS Programme, Ministry of Health and Population,; Cairo, Egypt.
- In 1993 an epidemic of human immunodeficiency virus (HIV) infection occurred among 39 patients at 2 renal dialysis centers in Egypt . The centers, private center A (PCA) and university center A (UCA) were visited, HIV-infected patients were interviewed, seroconversion rates at UCA we
- Short-course antenatal zidovudine reduces both cervicovaginal human immunodeficiency virus type 1 RNA levels and risk of perinatal transmission. Bangkok Collaborative Perinatal HIV Transmission Study Group.
- J Infect Dis. 2000 Jan;181(1):99-106. Unique Identifier : AIDSLINE MED/20087003
- Chuachoowong R; Shaffer N; Siriwasin W; Chaisilwattana P; Young NL; Mock PA; Chearskul S; Waranawat N; Chaowanachan T; Karon J; Simonds RJ; Mastro TD; Faculty of Medicine, Siriraj Hospital, Mahidol University, and; HIV/AIDS Collaboration, Nonthaburi, Thailand. rfc3@cdc.gov
- Human immunodeficiency virus (HIV) levels in cervicovaginal lavage (CVL) and plasma samples were evaluated in relation to perinatal transmission in a randomized placebo-controlled trial of brief antenatal zidovudine treatment. Samples were collected at 38 weeks gestation from 310 women and more frequently from a subs
- Glucocorticoids exacerbate the deleterious effects of gp120 in hippocampal and cortical explants.
- J Neurochem. 2000 Mar;74(3):1000-7. Unique Identifier : AIDSLINE MED/20155597
- Yusim A; Franklin L; Brooke S; Ajilore O; Sapolsky R; Department of Biological Sciences, Stanford University,; California 94305-5020, USA.
- Glucocorticoids (GCs), the adrenal steroids secreted during stress, can compromise the ability of hippocampal neurons to survive numerous necrotic insults. We have previously observed that GCs worsen the deleterious effects of gp120, the glycoprotein of the acquired immune deficiency syndrome virus, which can indirect
- Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea.
- J Nat Prod. 2000 Jan;63(1):29-33. Unique Identifier : AIDSLINE MED/20117914
- Cichewicz RH; Kouzi SA; Hamann MT; Division of Basic Pharmaceutical Sciences, School of Pharmacy,; University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.
- Resveratrol (trans-3,4 ,5-trihydroxystilbene) is produced by grapes (Vitis spp.) in response to microbial attack by the fungal grapevine pathogen Botrytis cinerea. Several reports indicate that pathogenic B.cinerea strains are capable of biotransforming resveratrol into an assortment of unidentified oxidized metabolit
- Effect of dexamethasone on lymphocyte subpopulations in premature infants with bronchopulmonary dysplasia.
- J Perinatol. 1999 Jul-Aug;19(5):347-51. Unique Identifier : AIDSLINE MED/20149516
- Parimi PS; Birnkrant DJ; Rao LV; Diaz G; Moore JJ; Department of Pediatrics, MetroHealth Medical Center, Case; Western Reserve University, Cleveland, OH, USA.
- OBJECTIVE: This study was designed to determine the effect of dexamethasone treatment on peripheral blood lymphocyte counts and subpopulations in premature infants with bronchopulmonary dysplasia (BPD). STUDY DESIGN: Peripheral blood lymphocyte subpopulations in 12 premature infants with BPD were analyzed before treat
- Human immunodeficiency virus (HIV)-related risk-taking behaviors in women attending inner-city prenatal clinics in the mid-west.
- J Perinatol. 1999 Oct-Nov;19(7):483-7. Unique Identifier : AIDSLINE MED/20149556
- Toltzis P; Stephens RC; Adkins I; Lombardi E; Swami S; Snell A; Cargill V; Department of Pediatrics, Case Western Reserve University School; of Medicine, Cleveland, OH, USA.
- OBJECTIVE: Federal guidelines recommend the provision of human immunodeficiency virus education to all attendees of prenatal clinics. The current study was conducted to assess risk-taking behaviors among urban women voluntarily pursuing prenatal care. DESIGN AND SETTING: African American women attending urban prenatal
- Predictors of symptomatic urinary tract infection after 20 weeks' gestation.
- J Perinatol. 1999 Oct-Nov;19(7):488-93. Unique Identifier : AIDSLINE MED/20149557
- Pastore LM; Savitz DA; Thorp JM Jr; Koch GG; Hertz-Picciotto I; Irwin DE; Department of Epidemiology, School of Public Health, University; of North Carolina, Chapel Hill 27599-7400, USA.
- OBJECTIVE: To identify predictors of symptomatic urinary tract infection (UTI) after 20 weeks gestation. STUDY DESIGN: A retrospective cohort analysis was conducted of all deliveries at three North Carolina hospitals between 1990 and 1993. A total of 7403 deliveries remained after exclusions (pre-pregnancy diabetes,
- Expression of potentially oncogenic HHV-8 genes in an EBV-negative primary effusion lymphoma occurring in an HIV-seronegative patient.
- J Pathol. 1999 Oct;189(2):288-93. Unique Identifier : AIDSLINE MED/20016442
- Cobo F; Hernandez S; Hernandez L; Pinyol M; Bosch F; Esteve J; Lopez-Guillermo A; Palacin A; Raffeld M; Montserrat E; Jaffe ES; Campo E; Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona,; Spain.
- Primary effusion lymphoma (PEL) is a novel lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection. Most PELs develop in HIV-seropositive individuals and are nearly always positive for Epstein-Barr virus (EBV), a finding which obscures the role of HHV-8 in lymphomagenesis. However, rare EBV-
- Immune cell populations in the equine corpus luteum throughout the oestrous cycle and early pregnancy: an immunohistochemical and flow cytometric study.
- J Reprod Fertil. 1999 Nov;117(2):281-90. Unique Identifier : AIDSLINE MED/20154785
- Lawler DF; Hopkins J; Watson ED; Department of Veterinary Clinical Studies, Royal (Dick) School of; Veterinary Studies, Easter Bush Veterinary Centre, Midlothian,; UK.
- Recent evidence indicates that the cells of the immune system and their large network of secretory products, or cytokines, play an active role in the ovary throughout the oestrous cycle. In the present study, immune cell populations (T and B lymphocytes, macrophages, granulocytes and eosinophils) and expression of maj
- Antenatal screening for HIV [letter]
- J R Soc Med. 1999 Oct;92(10):545. Unique Identifier : AIDSLINE MED/20157302
- de Zulueta P; Sheikh A
- Autoimmune enteropathy with goblet cell antibodies [letter]
- J R Soc Med. 1999 Oct;92(10):547. Unique Identifier : AIDSLINE MED/20157306
- Carr CS; Alkhulaifi AM
- The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.
- J Mol Biol. 2000 Jan 28;295(4):711-7. Unique Identifier : AIDSLINE MED/20123964
- Ippolito JA; Steitz TA; Department of Molecular Biophysics, Howard Hughes Medical; Institute, New Haven, CT 06520-8114, USA.
- The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-pu
- Selection of amino acid substitutions restoring activity of HIV-1 integrase mutated in its catalytic site using the yeast Saccharomyces cerevisiae.
- J Mol Biol. 2000 Jan 28;295(4):755-65. Unique Identifier : AIDSLINE MED/20123969
- Parissi V; Caumont AB; de Soultrait VR; Calmels C; Pichuantes S; Litvak S; Dupont CH; Laboratoire REGER, UMR 5097 CNRS-Universite Victor Segalen; Bordeaux 2, IFR 66 Pathologies Infectieuses. 1, rue Camille Saint; Saens, Bordeaux cedex, 33077, France.; vincent.parissi@ibgc.u-bordeaux2.fr
- The integration of proviral DNA into the genome of the host cell is an essential step in the replication of retroviruses. This reaction is catalyzed by a viral-encoded enzyme, the integrase (IN). We have previously shown that human immunodeficiency virus type 1 (HIV-1) IN causes a lethal effect when expressed in yeast
- Incidence of cervical squamous intraepithelial lesions in HIV-infected women.
- JAMA. 2000 Feb 23;283(8):1031-7. Unique Identifier : AIDSLINE MED/20160136
- Ellerbrock TV; Chiasson MA; Bush TJ; Sun XW; Sawo D; Brudney K; Wright TC Jr; Division of HIV/AIDS Prevention, Surveillance, and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA, USA.
- CONTEXT: Women infected with human immunodeficiency virus (HIV) are at increased risk for cervical squamous intraepithelial lesions (SILs), the precursors to invasive cervical cancer. However, little is known about the causes of this association. OBJECTIVES: To compare the incidence of SILs in HIV-infected vs uninfect
- From the Centers for Disease Control and Prevention. HIV/AIDS among racial/ethnic minority men who have sex with men--United States, 1989-1998 [published erratum appears in JAMA 2000 Mar 1;283(9):1136]
- JAMA. 2000 Feb 23;283(8):995-7. Unique Identifier : AIDSLINE MED/20160122
- Risk of HIV transmission through breastfeeding [letter]
- JAMA. 2000 Feb 23;283(8):999-1000. Unique Identifier : AIDSLINE MED/20160124
- Castetbon K; Spira R; Leroy V; Dabis F
- AIDS researchers explore new drug options [news]
- JAMA. 2000 Mar 1;283(9):1125. Unique Identifier : AIDSLINE MED/20166503
- Stephenson J
- Residual HIV-1 RNA after highly active antiretroviral therapy [letter]
- JAMA. 2000 Mar 1;283(9):1138-9. Unique Identifier : AIDSLINE MED/20166509
- Onuigbo MA
- Selective referral to high-volume hospitals: estimating potentially avoidable deaths [see comments]
- JAMA. 2000 Mar 1;283(9):1159-66. Unique Identifier : AIDSLINE MED/20166518
- Dudley RA; Johansen KL; Brand R; Rennie DJ; Milstein A; Department of Medicine, School of Medicine, and the Institute for; Health Policy Studies, University of California, San Francisco,; 94118, USA. adudley@itsa.ucsf.edu
- CONTEXT: Evidence exists that high-volume hospitals (HVHs) have lower mortality rates than low-volume hospitals (LVHs) for certain conditions. However, few employers, health plans, or government programs have attempted to increase the number of patients referred to HVHs. OBJECTIVES: To determine the difference in hosp
- Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial.
- JAMA. 2000 Mar 1;283(9):1167-74. Unique Identifier : AIDSLINE MED/20166519
- Nduati R; John G; Mbori-Ngacha D; Richardson B; Overbaugh J; Mwatha A; Ndinya-Achola J; Bwayo J; Onyango FE; Hughes J; Kreiss J; Department of Paediatrics, University of Nairobi, Kenya.
- CONTEXT: Transmission of human immunodeficiency virus type 1 (HIV-1) is known to occur through breastfeeding, but the magnitude of risk has not been precisely defined. Whether breast milk HIV-1 transmission risk exceeds the potential risk of formula-associated diarrheal mortality in developing countries is unknown. OB
- Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice.
- JAMA. 2000 Mar 1;283(9):1175-82. Unique Identifier : AIDSLINE MED/20166520
- De Cock KM; Fowler MG; Mercier E; de Vincenzi I; Saba J; Hoff E; Alnwick DJ; Rogers M; Shaffer N; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.; kmd2@cdc.gov
- Each year, an estimated 590,000 infants acquire human immunodeficiency virus type 1 (HIV) infection from their mothers, mostly in developing countries that are unable to implement interventions now standard in the industrialized world. In resource-poor settings, the HIV pandemic has eroded hard-won gains in infant and
- Dominant T cells in idiopathic nephrotic syndrome of childhood.
- Kidney Int. 2000 Feb;57(2):510-7. Unique Identifier : AIDSLINE MED/20117958
- Frank C; Herrmann M; Fernandez S; Dirnecker D; Boswald M; Kolowos W; Ruder H; Haas JP; Children's Hospital and Institute for Clinical Immunology,; Friedrich-Alexander University, Erlangen-Nuremberg,and Children's; Rheumatology Hospital, Garmisch-Partenkirchen, Germany.
- BACKGROUND: Because of several studies, idiopathic nephrotic syndrome (INS) of childhood is suspected to have an immunologic pathogenesis with T cells playing a major role. To investigate this hypothesis further, we studied the diversity of the CDR3 region of the T-cell receptor (TCR) beta-chain from peripheral T cell
- Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis.
- Kidney Int. 2000 Feb;57(2):518-25. Unique Identifier : AIDSLINE MED/20117959
- Kitching AR; Tipping PG; Timoshanko JR; Holdsworth SR; Center for Inflammatory Diseases, Monash University Department of; Medicine, Monash Medical Center, Clayton, Victoria, Australia.; richard.kitching@med.monash.edu.au
- BACKGROUND: Interleukin (IL)-10 plays a pivotal role in regulating the Th1/Th2 predominance of immune responses. Exogenously administered IL-10 suppresses nephritogenic Th1 responses, inhibits macrophage function, and attenuates crescentic glomerulonephritis (GN). To determine the role of endogenous IL-10, the develop
- Aging affects the regeneration of the CD8+ T cell compartment in bone marrow transplanted mice.
- Mech Ageing Dev. 2000 Jan 3;112(2):113-24. Unique Identifier : AIDSLINE MED/20152783
- Mu XY; Thoman ML; Department of Immunology, Sidney Kimmel Cancer Center, San Diego,; CA 92121, USA.
- A chimeric mouse model has been used to determine the effect of aging on the differentiation of CD8+ T cells and on the regeneration capacity of the mature peripheral T cell pool after radiation induced depletion. Bone marrow cells from Thy 1.1+ mice were transplanted into lethally irradiated young or aged mice (Thy 1
- Infectiousness of Mycobacterium tuberculosis in HIV-1-infected patients with tuberculosis: a prospective study.
- Lancet. 2000 Jan 22;355(9200):275-80. Unique Identifier : AIDSLINE MED/20137540
- Espinal MA; Perez EN; Baez J; Henriquez L; Fernandez K; Lopez M; Olivo P; Reingold AL; National Centre for Research on Maternal and Child Health, Santo; Domingo, Dominican Republic. espinalm@who.ch
- BACKGROUND: Previous studies concerning the relative infectiousness of HIV-1-positive individuals with pulmonary tuberculosis have produced conflicting results. Thus, we assessed the effect of HIV-1 on the infectiousness of Mycobacterium tuberculosis in a prospective study. METHODS: We organised in Santo Domingo,
- Structured treatment interruptions to control HIV-1 infection [letter]
- Lancet. 2000 Jan 22;355(9200):287-8. Unique Identifier : AIDSLINE MED/20137545
- Lori F; Maserati R; Foli A; Seminari E; Timpone J; Lisziewicz J
- Structured treatment interruptions progressively lowered the rate of viral rebound in some HIV-1 infected patients. This approach should be explored as an alternative to continuous antiretroviral therapies.
- Subunit-dependent inhibition of recombinant rodent N-methyl-D-aspartate receptors by a HIV-1 glycoprotein 120 derived peptide.
- Neurosci Lett. 2000 Feb 18;280(2):151-4. Unique Identifier : AIDSLINE MED/20153732
- Wittekindt B; Betz H; Laube B; Department of Neurochemistry, Max-Planck-Institute for Brain; Research, Deutschordenstrasse 46, 60528, Frankfurt, Germany.
- Considerable evidence suggests that low (picomolar) concentrations of the HIV-1 envelope glycoprotein gp120 induce neuronal cell death by stimulating the release of microglial toxins, which in turn activate N-methyl-D-aspartate (NMDA) receptors. Conversely, high (micromolar) concentrations of gp120 have been reported
- HIV in 2000: historical perspectives and an outlook for the future [news]
- Nurse Pract. 2000 Jan;25(1):103-6, 109. Unique Identifier : AIDSLINE MED/20128388
- Klaus BD; Grodesky MJ
- Adolescents and sexually transmissible diseases.
- Obstet Gynecol Clin North Am. 2000 Mar;27(1):163-79. Unique Identifier : AIDSLINE MED/20157577
- Vermillion ST; Holmes MM; Soper DE; Department of Obstetrics and Gynecology, Medical University of; South Carolina, Charleston, USA. vermills@musc.edu
- Sexually transmitted infections are alarmingly common among adolescents in the United States . Behavioral, biologic, and health care access factors place adolescent girls at high risk for many common infections. This population also experiences a disproportionate burden related to the s
- Comparison of ritonavir plus saquinavir- and nelfinavir plus saquinavir-containing regimens as salvage therapy in children with human immunodeficiency type 1 infection.
- Pediatr Infect Dis J. 2000 Jan;19(1):47-51. Unique Identifier : AIDSLINE MED/20106644
- Hoffmann F; Notheis G; Wintergerst U; Eberle J; Gurtler L; Belohradsky BH; Children's Hospital of the Ludwig Maximilians-University Munich,; Germany. ida@KK-i.med.uni-muenchen.de
- BACKGROUND: In this retrospective study we compared the antiretroviral effect of regimens consisting of simultaneous administration of two protease inhibitors (PI) with at least one nucleoside reverse transcriptase inhibitor on plasma viral load (VL) and CD4 cell co
- Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children.
- Pediatr Infect Dis J. 2000 Jan;19(1):66-72. Unique Identifier : AIDSLINE MED/20106647
- Michelow IC; Nicol M; Tiemessen C; Chezzi C; Pettifor JM; Department of Paediatrics and Child Health, University of; Witwatersrand, Johannesburg, South Africa.; imiche@mednet.swmed.edu
- BACKGROUND: Current laboratory tests often cannot distinguish between bacterial and aseptic meningitis rapidly and accurately. The ability to make a prompt diagnosis has important implications for the management and outcome of children with meningitis. The observation that leukocytes aggregate in the cerebrospinal flu
- A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.
- Unique Identifier : AIDSLINE MED/20105443
- Pereira LA; Bentley K; Peeters A; Churchill MJ; Deacon NJ; AIDS Molecular Biology Unit, National Centre for HIV Virology; Research, The Macfarlane Burnet Centre for Medical Research, PO; Box 254, Fairfield, Victoria 3078, Australia.
- The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. T
- Selection of functional tRNA primers and primer binding site sequences from a retroviral combinatorial library: identification of new functional tRNA primers in murine leukemia virus replication.
- Unique Identifier : AIDSLINE MED/20105459
- Lund AH; Duch M; Pedersen FS; Department of Molecular and Structural Biology, University of; Aarhus, Denmark.
- Retroviral reverse transcription is initiated from a cellular tRNA molecule and all known exogenous isolates of murine leukemia virus utilise a tRNA(Pro)molecule. While several studies suggest flexibility in murine leukemia virus primer utilisation, studies on human immunodeficiency virus and avian retro-viruses have
- Human immunodeficiency virus drug resistance testing: state of the art in genotypic and phenotypic testing of antiretrovirals.
- Pharmacotherapy. 2000 Feb;20(2):151-7. Unique Identifier : AIDSLINE MED/20141761
- Romanelli F; Pomeroy C; Division of Pharmacy Practice and Science, College of Pharmacy,; University of Kentucky, Lexington 40536, USA.
- Antiretroviral drugs have significantly reduced death rates from the acquired immunodeficiency syndrome in the United States . They are highly effective in reducing viral replication, but their utility is threatened by rapid development of drug resistance. Although antiretroviral drug r
- Aerosolized antimicrobial therapy in acutely ill patients.
- Pharmacotherapy. 2000 Feb;20(2):166-81. Unique Identifier : AIDSLINE MED/20141763
- Wood GC; Boucher BA; Department of Clinical Pharmacy, College of Pharmacy, The; University of Tennessee, Memphis 38163, USA.
- Recent data are sparking renewed interest in therapy with aerosolized antimicrobials in critically ill patients as well as other populations such as those with neutropenia, human immunodeficiency virus infection, and cystic fibrosis. Pneumonia is a common complication in these patients and is associated with substanti
- Effects of photoperiod and melatonin on lymphocyte activities in male broiler chickens.
- Poult Sci. 2000 Jan;79(1):18-25. Unique Identifier : AIDSLINE MED/20148320
- Kliger CA; Gehad AE; Hulet RM; Roush WB; Lillehoj HS; Mashaly MM; Department of Poultry Science, The Pennsylvania State University,; University Park 16802-3501, USA.
- Understanding the role of the pineal gland in regulating the immune response and the role of photoperiod in influencing pineal gland secretions are becoming increasingly important. The purposes of the present experiments were to investigate the effects of different photoperiod regimens on T- and B-lymphocyte activitie
- Granulocyte chemiluminescence activity, antibody production and percentage of CD4(+) and CD8(+) lymphocytes in peripheral blood of offspring of salbutamol-treated pregnant C3H mice.
- Pharmacol Res. 2000 Jan;41(1):89-94. Unique Identifier : AIDSLINE MED/20070169
- Kaminski P; Skopinska-Rozewska E; Wasik M; Barcz E; Bany J; Marianowski L; Department of Obstetrics and Gynaecology, The Medical University; of Warsaw, Poland.
- Preterm delivery is one of the most important problems in obstetric care. One of commonly used treatment of such high risk cases is salbutamol-beta(2) adrenoceptor agonist. The aim of present study was to determine if such treatment causes any changes in neonatal immune system and therefore should be considered in new
- Combined antiviral treatment in HIV infection. Is it value for money?
- Public Health. 1999 Nov;113(6):315-7. Unique Identifier : AIDSLINE MED/20105791
- Davies D; Carne C; Camilleri-Ferrante C; Anglia Clinical Audit and Effectiveness Team (ACET), Institute of; Public Health, University Forvie Site, Robinson Way, Cambridge,; CB2 2SR, UK.
- There is compelling evidence that combinations of antiretroviral drugs are significantly more effective than monotherapy and appear, at least in the short run, to offset problems caused by the rapid emergence of drug resistance which is characteristic of human immunodeficiency virus (HIV) infection.1,2 The routine pre
- 3rd Brazilian Symposium on Basic Research of HIV/AIDS. Comandatuba, Brahia, Brazil. 16-20 October 1999. Abstracts.
- Rev Inst Med Trop Sao Paulo. 1999 Oct;41 Suppl 11:S1-72. Unique Identifier : AIDSLINE MED/20166071
- Intranasal administration of recombinant mouse interleukin-12 increases inflammation and demyelination in chronic experimental autoimmune neuritis in Lewis rats.
- Scand J Immunol. 2000 Jan;51(1):29-35. Unique Identifier : AIDSLINE MED/20098785
- Pelidou SH; Zou LP; Deretzi G; Nennesmo I; Wei L; Mix E; Van Der Meide PH; Zhu J; Division of Geriatric Medicine, Karolinska Institute, Huddinge; University Hospital, Stockholm, Sweden.
- To examine whether interleukin (IL)-12 modulates ongoing chronic experimental autoimmune neuritis (EAN), we evaluated the effects of recombinant mouse IL-12 (rmIL-12) in Lewis rats with chronic EAN, induced by immunization with P0 peptide (180-199) plus complete Freund s adjuvant. Rats were treated intranasally with e
- Self and nonself stimulatory molecules induce preferential expansion of CD5+ B cells or activated T cells of chagasic patients, respectively.
- Scand J Immunol. 2000 Jan;51(1):91-7. Unique Identifier : AIDSLINE MED/20098794
- Dutra WO; Colley DG; Pinto-Dias JC; Gazzinelli G; Brener Z; Pereira ME; Coffman RL; Correa-Oliveira R; Carvalho-Parra JF; Departamento de Morfologia, Instituto de Ciencias Biologicas,; Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627,; Pampulha, Belo Horizonte, 31270-911, MG, Brazil.
- It has previously been demonstrated that Trypanosoma cruzi-derived antigens (TRP) and human parasite-specific antibodies (Id) stimulate proliferation of cells from Chagasic patients. More recently, we have shown that activated T cells and CD5+ B cells are present in elevated levels in the peripheral blood of Chagasic
- First person account: schizophrenia, substance abuse, and HIV.
- Schizophr Bull. 1999;25(4):863-6. Unique Identifier : AIDSLINE MED/20129216
- Hummingbird
- [HIV 1999: suppression at what price?]
- Schweiz Med Wochenschr. 1999 Dec 28;129(51-52):2010-3. Unique Identifier : AIDSLINE MED/20139265
- Vernazza PL; Departement Innere Medizin Kantonsspital, St. Gallen.; Pietro.Vernazza@kssg.ch
- Policy forum: public health. The health and wealth of nations.
- Science. 2000 Feb 18;287(5456):1207, 1209. Unique Identifier : AIDSLINE MED/20168410
- Bloom DE; Canning D; Harvard University School of Public Health.
- Current status of infection-related gastrointestinal and hepatobiliary diseases in Thailand.
- Southeast Asian J Trop Med Public Health. 1999 Mar;30(1):96-105. Unique Identifier : AIDSLINE MED/20158343
- Kullavanijaya P; Tangkijvanich P; Poovorawan Y; Department of Medicine, Faculty of Medicine, Chulalongkorn; University and Hospital, Bangkok, Thailand.
- The objective of this overview is to assess the present situation with regards to gastrointestinal and hepatobiliary diseases prevailing in Thailand . In that context, special emphasis has been put on those forms of viral hepatitis prevalent in the region, namely, hepatitis A the
- Evaluating AIDS prevention interventions using behavioral and biological outcome measures.
- Sex Transm Dis. 2000 Feb;27(2):101-10. Unique Identifier : AIDSLINE MED/20140147
- Fishbein M; Pequegnat W; Annenberg Public Policy Center, Annenberg School for; Communication, University of Pennsylvania, Philadelphia 19104,; USA.
- OBJECTIVE: To begin a dialogue on the role of behavioral and biological outcome measures in evaluating the effectiveness of behavior change interventions to reduce the risk of transmitting and acquiring HIV and other sexually transmitted diseases (STDs). METHODS: A selective review of the literature was undertaken to
- Acceptability of formulations and application methods for vaginal microbicides among drug-involved women: results of product trials in three cities.
- Sex Transm Dis. 2000 Feb;27(2):119-26. Unique Identifier : AIDSLINE MED/20140150
- Hammett TM; Mason TH; Joanis CL; Foster SE; Harmon P; Robles RR; Finlinson HA; Feudo R; Vining-Bethea S; Jeter G; Mayer KH; Doherty-Iddings P; Seage GR 3rd; Abt Associates Inc, Cambridge, Massachusetts 02138-1168, USA.; ted_hammett@abtassoc.com
- BACKGROUND AND OBJECTIVES: Female-controlled methods of HIV prevention, such as vaginal microbicides, are urgently needed, particularly among drug-involved women. Acceptability research is critical to product development. GOAL: To assess the acceptability of forms and application methods for future microbicides. DESIG
- Syphilis in Atlanta during an era of declining incidence.
- Sex Transm Dis. 2000 Feb;27(2):68-73. Unique Identifier : AIDSLINE MED/20140142
- Fleming DT; Levine WC; Trees DL; Tambe P; Toomey K; St. Louis ME; Division of STD Prevention, National Center for HIV, STD and TB; Prevention. Flemindt@umdnj.edu
- BACKGROUND: Syphilis transmission in Atlanta is ongoing despite declining incidence. OBJECTIVES: To identify risk factors and missed opportunities for prevention. STUDY DESIGN: A case-control study design was used. Twenty-five sexually transmitted disease (STD) clinic patients with primary or secondary syphilis by pol
- Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases.
- Sex Transm Dis. 2000 Feb;27(2):87-92. Unique Identifier : AIDSLINE MED/20140145
- Giuliani M; Rezza G; Lepri AC; Di Carlo A; Maini A; Crescimbeni E; Palamara G; Prignano G; Caprilli F; Centro Operativo AIDS-Istituto Superiore di Sanita, Rome, Italy.
- BACKGROUND: To date, few studies have provided information on risk factors for human t-lymphotropic viruses (HTLV) types I and II in European countries. In particular, few data are available from published studies conducted in STD centers. GOALS: To identify risk factors for HTLV-I and HTLV-II infection and to better
- Predictors of female condom use among women exchanging street sex in New York City.
- Sex Transm Dis. 2000 Feb;27(2):93-100. Unique Identifier : AIDSLINE MED/20140146
- Witte SS; Wada T; El-Bassel N; Gilbert L; Wallace J; Social Intervention Group, Columbia University School of Social; Work, New York, New York, USA.
- BACKGROUND: Alternative female-initiated barrier methods, such as the female condom, are needed among women exchanging street sex to enhance their ability to protect themselves from HIV and STD infection. OBJECTIVE: To describe predictors of female condom use among 96 women exchanging sex for money and drugs on the st
- Association of DRB1*1501 with disseminated Mycobacterium avium complex infection in North American AIDS patients.
- Tissue Antigens. 2000 Jan;55(1):17-23. Unique Identifier : AIDSLINE MED/20166343
- LeBlanc SB; Naik EG; Jacobson L; Kaslow RA; Department of Epidemiology, School of Public Health, University; of Alabama at Birmingham, 35294-0022, USA.
- The HLA class II allele, DR2 (DRB1*1501), has been repeatedly found to be associated with development of tuberculosis and leprosy. We searched for associations of these and other class II alleles with disseminated Mycobacterium avium complex infection (DMAC) in North American Caucasian homosexual AIDS patients. Molecu
- Intravirion targeting of a functional anti-human immunodeficiency virus ribozyme directed to pol.
- Virology. 2000 Feb 15;267(2):174-84. Unique Identifier : AIDSLINE MED/20130732
- Giordano V; Jin DY; Rekosh D; Jeang KT; Molecular Virology Section, Laboratory of Molecular Microbiology,; National Institute of Allergy and Infectious Diseases, 9000; Rockville Pike, Bethesda, Maryland 20892-0460, USA.
- Ribozymes are catalytic RNAs that offer several advantages as specific therapeutic genes against human immunodeficiency virus type 1 (HIV-1). Significant challenges in antiviral uses of ribozymes include (1) how best to express and to deliver this agent and (2) what is the best locale to target ribozymes against HIV-1
- Effects of oligomerization on the epitopes of the human immunodeficiency virus type 1 envelope glycoproteins.
- Virology. 2000 Feb 15;267(2):220-8. Unique Identifier : AIDSLINE MED/20130736
- Gorny MK; VanCott TC; Williams C; Revesz K; Zolla-Pazner S; Department of Pathology, New York University School of Medicine,; New York, New York 10016, USA.
- To understand the differential expression of epitopes on monomeric and oligomeric forms of the envelope glycoproteins, nine human monoclonal antibodies (mAbs) were derived from the cells of human immunodeficiency virus-infected subjects by selection with soluble oligomeric gp140 (o.140). These nine mAbs and 12 human m
- MLV-derived retroviral vectors selective for CD4-expressing cells and resistant to neutralization by sera from HIV-infected patients.
- Virology. 2000 Feb 15;267(2):229-36. Unique Identifier : AIDSLINE MED/20130737
- Stitz J; Steidl S; Merget-Millitzer H; Konig R; Muller P; Nocken F; Engelstadter M; Bobkova M; Schmitt I; Kurth R; Buchholz CJ; Cichutek K; Department of Medical Biotechnology, Paul-Ehrlich-Institut,; Paul-Ehrlich-Str. 51-59, Langen, D-63225, Germany.
- Retroviral vectors derived from amphotropic murine leukemia viruses (MLV) mediate gene transfer into almost all human cells and are thus not suitable for in vivo applications in gene therapy in which cell-specific gene delivery is required. We and others recently reported the generation of MLV-derived vectors pseudoty
- Susceptibility of in vitro stimulated PBMC to infection with NSI HIV-1 is associated with levels of CCR5 expression and beta-chemokine production.
- Virology. 2000 Feb 15;267(2):237-46. Unique Identifier : AIDSLINE MED/20130738
- Blaak H; Ran LJ; Rientsma R; Schuitemaker H; Department of Clinical Viro-Immunology, CLB and Laboratory for; Experimental and Clinical Immunology, University of Amsterdam,; Academic Medical Center, Amsterdam, Plesmanlaan 125, Amsterdam,; 1066 CX, The Netherlands.
- Susceptibility of PHA/rIL-2-stimulated PBMC from 14 healthy blood donors for NSI HIV-1 infection was analyzed in relation to CCR5 expression and beta-chemokine production. After 1 week of culture in the presence of rIL-2, but not at the moment of inoculation, CCR5 surface expression was positively and beta-chemokine p
- Differential expression of the HHV-8 vGCR cellular homolog gene in AIDS-associated and classic Kaposi's sarcoma: potential role of HIV-1 Tat.
- Virology. 2000 Feb 15;267(2):247-51. Unique Identifier : AIDSLINE MED/20130739
- Yen-Moore A; Hudnall SD; Rady PL; Wagner RF Jr; Moore TO; Memar O; Hughes TK; Tyring SK; Department of Dermatology, The University of Texas Medical; Branch, Galveston, Texas 77555, USA.
- Human herpesvirus 8 (HHV-8) has been causally linked to Kaposi s sarcoma (KS). There is significant homology between some HHV-8 genes and cellular genes including D-type cyclin (vCYC), G protein coupled receptor (vGCR), macrophage inflammatory proteins (vMIP-I, vMIP-II), bcl-2 (vBCL2), interferon regulatory factor-1 (
- Induction of cytotoxic T lymphocyte activity by fusion-active peptide-containing virosomes.
- Vaccine. 2000 Jan 31;18(14):1327-33. Unique Identifier : AIDSLINE MED/20087288
- Arkema A; Huckriede A; Schoen P; Wilschut J; Daemen T; University of Groningen, Department of Physiological Chemistry,; Ant. Deusinglaan 1, 9713 AV, Groningen, Netherlands.
- Priming of cytotoxic T lymphocyte (CTL) activity with exogenous antigen requires introduction of the antigen into the MHC class I presentation pathway of antigen-presenting cells. In the present study, we used fusogenic reconstituted envelopes (virosomes), derived from influenza virus, as a carrier system for delivery
- Kaposi sarcoma after treatment of Hodgkin's disease in a young adult non-AIDS patient: case report and review.
- Am J Clin Oncol. 2000 Feb;23(1):26-8. Unique Identifier : AIDSLINE MED/20145274
- Deutsch M; Jacobs SA; Department of Radiation Oncology, University of Pittsburgh; Medical Center, Pennsylvania 15213, USA.
- We describe a young woman diagnosed with Hodgkin s disease, stage I, at age 20 years. She delayed treatment until age 23, at which time she was considered to have stage II-A disease and was then treated with chemotherapy and involved field irradiation. Two years later, Kaposi sarcoma, which developed on her right shou
- Declining prevalence of opportunistic gastrointestinal disease in the era of combination antiretroviral therapy.
- Am J Gastroenterol. 2000 Feb;95(2):457-62. Unique Identifier : AIDSLINE MED/20148186
- Monkemuller KE; Call SA; Lazenby AJ; Wilcox CM; Department of Medicine, University of Alabama at Birmingham,; 35294-0007, USA.
- OBJECTIVE: Opportunistic disorders (OD) are the most frequent GI manifestations of the acquired immunodeficiency syndrome (AIDS). Since the introduction of highly active antiretroviral therapy (HAART), there appears to be have been a reduction in the incidence of many of these OD; however, the effect of HAART on the p
- Maintenance hemodialysis decreases serum hepatitis C virus (HCV) RNA levels in hemodialysis patients with chronic HCV infection.
- Am J Gastroenterol. 2000 Feb;95(2):490-6. Unique Identifier : AIDSLINE MED/20148192
- Furusyo N; Hayashi J; Ariyama I; Sawayama Y; Etoh Y; Shigematsu M; Kashiwagi S; Department of General Medicine, Kyushu University Hospital,; Fukuoka, Japan.
- OBJECTIVE: Hepatitis C virus (HCV) infection is a major complication among hemodialysis patients the world over. To determine the natural course of HCV viremic levels in patients on maintenance hemodialysis, we prospectively quantified the HCV RNA levels in serial blood samples from hemodialysis patients and compared
- Frequent T and B cell oligoclones in histologically and immunophenotypically characterized angioimmunoblastic lymphadenopathy.
- Am J Pathol. 2000 Feb;156(2):661-9. Unique Identifier : AIDSLINE MED/20132836
- Smith JL; Hodges E; Quin CT; McCarthy KP; Wright DH; Molecular Immunology Group of the Wessex Immunology Service,; Department of Pathology, Southampton University Hospitals; National Health Service Trust, Southampton, United Kingdom.; smithj6@hotmail.com
- The identification of clonal rearrangements of T cell receptor (TCR) genes is central to the diagnosis of T cell lymphomas. However, in angioimmunoblastic lymphadenopathy (AILD), first described as a nonneoplastic proliferation associated with immunodeficiency, the heterogeneity of TCR and IgH gene rearrangements sugg
- Otologic and audiologic evaluation of human immunodeficiency virus-infected patients.
- Am J Otolaryngol. 2000 Jan-Feb;21(1):1-9. Unique Identifier : AIDSLINE MED/20132104
- Chandrasekhar SS; Connelly PE; Brahmbhatt SS; Shah CS; Kloser PC; Baredes S; Divisions of Otolaryngology--Head and Neck Surgery, University of; Medicine and Dentistry of New Jersey, New Jersey Medical School,; Newark 07103-2714, USA.
- PURPOSE: To quantify the incidence of ear disease in patients infected with human immunodeficiency virus (HIV). MATERIALS AND METHODS: This is a descriptive case series of HIV-positive patients, with data collected using an otologic questionnaire. otologic examination, audiologic evaluation, and chart review. The stud
- Head and neck manifestations of non-Hodgkin's lymphoma in human immunodeficiency virus-infected patients.
- Am J Otolaryngol. 2000 Jan-Feb;21(1):10-3. Unique Identifier : AIDSLINE MED/20132105
- Singh B; Poluri A; Shaha AR; Michuart P; Har-El G; Lucente FE; Department of Otolaryngology, State University of New York-Health; Science Center at Brooklyn, USA.
- PURPOSE: Non-Hodgkin s lymphoma is the 2nd most common malignancy in human immunodeficiency virus (HIV)-infected patients. However, limited information regarding head and neck manifestations of non-Hodgkin s lymphoma is present in the literature. The aim of this article is to descr
- [Primary infection in vertically infected HIV-1 infants: biological characteristics of isolated virus, viral load and CD4 t-lymphocytes]
- An Esp Pediatr. 1999 Nov;51(5):469-74. Unique Identifier : AIDSLINE MED/20118389
- Resino Garcia S; Jimenez Fuentes JL; Gurbindo Gutierrez D; Navarro J; Abad ML; Munoz-Fernandez MA; Servicio de Inmunologia, Hospital General Universitario,; Gregorio Maranon, Madrid.
- OBJECTIVE: Our aim was to study the relationship between virological and/or immunological markers during the first month of life in vertically HIV-1 infected infants without prior antiviral treatment. PATIENTS AND METHODS: Thirty HIV-1 infected infants that had not received prior antiviral therapy, nor had their mothe
- [Adolescents with clinical course suggestive of acquired immunodeficiency and non-confirming conventional tests (letter)]
- An Esp Pediatr. 1999 Nov;51(5):570-1. Unique Identifier : AIDSLINE MED/20118406
- Mur Sierra A; Garcia Lopez C; Vinolas Tolosa M; Bonet M; Sanchez Garcia-Vao C; Soriano V
- Caspase inhibitor blocks human immunodeficiency virus 1-induced T-cell death without enhancement of HIV-1 replication and dimethyl sulfoxide increases HIV-1 replication without influencing T-cell survival.
- Arch Pathol Lab Med. 2000 Feb;124(2):240-5. Unique Identifier : AIDSLINE MED/20122196
- Taddeo B; Nickoloff BJ; Foreman KE; Department of Pathology, Skin Cancer Research Laboratories,; Cardinal Bernardin Cancer Center, Loyola University Medical; Center, Maywood, Illinois, USA.
- OBJECTIVES: To determine the relationship, if any, between reagents that modulate survival of T-cells and replication of human immunodeficiency virus 1 (HIV-1) and to determine the effects of the solvent dimethyl sulfoxide (DMSO) and drugs such as cyclosporin A and all-trans retinoic acid on HIV-1 replication. DESIGN:
- Detection of indinavir crystals in urine: dependence on method of analysis.
- Arch Pathol Lab Med. 2000 Feb;124(2):246-50. Unique Identifier : AIDSLINE MED/20122197
- Hortin GL; King C; Miller KD; Kopp JB; Clinical Pathology Department, Warren Grant Magnusson Clinical; Center, National Institute of Diabetes and Digestive Kidney; Diseases, National Institutes of Health, Bethesda, MD, USA.
- OBJECTIVES: To determine the frequency of crystalluria in patients treated with the human immunodeficiency virus protease inhibitor indinavir and to compare methods of detecting crystalluria. METHODS: A total of 308 freshly voided urine specimens from
- Aggressive natural killer cell lymphoma presenting as an anterior mediastinal mass in a patient with acquired immunodeficiency syndrome.
- Arch Pathol Lab Med. 2000 Feb;124(2):304-9. Unique Identifier : AIDSLINE MED/20122209
- Tao J; Savargaonkar P; Vallejo C; Cesarman E; Fuchs A; Department of Pathology, Long Island Jewish Medical Center, The; Long Island Campus for the Albert Einstein College of Medicine,; New Hyde Park, NY, USA.
- We report a case of aggressive natural killer cell lymphoma presenting as an anterior mediastinal mass in an African-American man with acquired immunodeficiency syndrome. Histologically, the anterior mediastinal mass showed a diffuse dense infiltrate of atypical intermediate-sized and large lymphoid cells, as well as
- Coccidioidomycosis meningitis with massive dural and cerebral venous thrombosis and tissue arthroconidia.
- Arch Pathol Lab Med. 2000 Feb;124(2):310-4. Unique Identifier : AIDSLINE MED/20122210
- Kleinschmidt-DeMasters BK; Mazowiecki M; Bonds LA; Cohn DL; Wilson ML; Department of Pathology, University of Colorado Health Sciences; Center, Denver, CO 80262, USA.
- To our knowledge we report the first case of meningitis from Coccidioides immitis associated with massive dural and cerebral venous thrombosis and with mycelial forms of the organism in brain tissue. The patient was a 43-year-old man with late-stage acquired immunodeficiency syndrome (AIDS) whose premortem and postmor
- Repair of chronic anorectal fistulae using commercial fibrin sealant.
- Arch Surg. 2000 Feb;135(2):166-9. Unique Identifier : AIDSLINE MED/20132359
- Park JJ; Cintron JR; Orsay CP; Pearl RK; Nelson RL; Sone J; Song R; Abcarian H; Department of Surgery, The University of Illinois Hospital and; Clinics, Chicago, USA.
- HYPOTHESIS: Commercially produced fibrin sealant can be used to completely close both simple and complex fistulae in ano. METHODS: A 29-patient prospective nonrandomized clinical trial was performed. In the operating room, the patient underwent an examination with anesthesia and the primary and secondary fistula tract
- Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?
- Biochem Biophys Res Commun. 2000 Jan 27;267(3):677-85. Unique Identifier : AIDSLINE MED/20139710
- Azad AA; Biomolecular Research Institute, 343 Royal Parade, Parkville,; Victoria, 3052, Australia. Ahmed.Azad@bioresi.com.au
- A growing body of literature suggests that the HIV accessory proteins Nef and Vpr could be involved in depletion of CD4(+) and non-CD4(+) cells and tissue atrophy, and in delaying the death of HIV-infected cells. Cell depletion is likely to be predominantly a bystander effect because the number of cells dying far outn
- [Mechanism of action of aspartic proteinases. V. Conformational characteristics of fragments of substrate-binding sites in rhizopuspepsin and HIV-1 proteinase]
- Bioorg Khim. 1999 Aug;25(8):597-602. Unique Identifier : AIDSLINE MED/20045427
- Kashparov IV; Popov ME; Rumsh LD; Popov EM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian; Academy of Sciences, Moscow, Russia. ilko@enzyme.siobc.ras.ru
- The conformational states of side chains of catalytic Asp residues in active sites of HIV-1 protease and rhizopuspepsin in the potential field of free enzymes were studied by using theoretical conformational analysis. Structural factors that stabilize the conformation of these residues in free enzymes were revealed. M
- Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection.
- Arthritis Rheum. 2000 Feb;43(2):365-9. Unique Identifier : AIDSLINE MED/20155543
- Soden M; Vasudevan H; Roberts B; Coelen R; Hamlin G; Vasudevan S; La Brooy J; University of Queensland, Townsville, Australia.
- OBJECTIVE: To document the histology of Ross River virus (RRV) arthritis and to examine inflamed synovium for viral RNA. METHODS: Biopsy tissue from the inflamed knees of 12 patients with RRV infection was studied using conventional and immunostaining techniques. Reverse transcriptase-polymerase chain reaction technol
- Infant-feeding patterns and HIV-1 transmission [letter; comment]
- Lancet. 1999 Nov 27;354(9193):1903. Unique Identifier : AIDSLINE MED/20049440
- Numazaki K; Chiba S
- Sumatriptan increases the proliferation of peripheral blood mononuclear cells from HIV-infected individuals and healthy blood donors in vitro.
- APMIS. 2000 Jan;108(1):74-8. Unique Identifier : AIDSLINE MED/20161914
- Afzelius P; Nielsen JO; Department of Infectious Diseases 144, Hvidovre Hospital,; Denmark.
- HIV infection is characterized by the loss of CD4+ T cells as well as the loss of T-cell function, leading to severe immunodeficiency. The proliferative capacity of T cells measured in vitro as responses to antigens and mitogens is severely reduced during HIV infection. An increased level of the intracellular second ma
- Virus safety of avital bone tissue transplants: evaluation of sterilization steps of spongiosa cuboids using a peracetic acid-methanol mixture.
- Biologicals. 1999 Sep;27(3):195-201. Unique Identifier : AIDSLINE MED/20119163
- Pruss A; Kao M; Kiesewetter H; von Versen R; Pauli G; Institute for Transfusion Medicine, Tissue Bank, University; Hospital Charite, Medical Faculty of Humboldt-University Berlin,; Germany.
- The aim of this study was to validate the virus-inactivating/eliminating capacity of the manufacturing process of spongiosa cuboids. Both the sterilization step with peracetic acid (PAA)/ethanol and the defatting step of bones with chloroform/methanol (2:1, v/v) were investigated. Relevant enveloped, non-enveloped, ana
- The role of family and friend social support in reducing risk behaviors among HIV-positive Gay men.
- AIDS Educ Prev. 1999 Dec;11(6):465-75. Unique Identifier : AIDSLINE MED/20155311
- Kimberly JA; Serovich JM; Office of Program Evaluation and Research, Ohio Department of; Mental Health, Columbus 43266, USA.; kimberlyj@mhmail.mh.state.oh.us
- Researchers have intimated a link between social support and risk-taking behaviors for HIV-positive persons, yet few have empirically examined this assumption. This study examined HIV-positive Gay men regarding their perceptions of family and friend social support, behavioral intentions, and risk-taking behaviors. Resa
- Sexual risk behaviors of Gay, Lesbian, and bisexual youths in New York City: prevalence and correlates.
- AIDS Educ Prev. 1999 Dec;11(6):476-96. Unique Identifier : AIDSLINE MED/20155312
- Rosario M; Meyer-Bahlburg HF; Hunter J; Gwadz M; Department of Psychology, City College and Graduate School, The; City University of New York, NY 10031, USA.
- The lifetime and recent sexual risk behaviors of 156 Gay, Lesbian, and bisexual youths, recruited from Gay-focused organizations in New York City, were examined. The data indicated seven reasons why the youths are at risk for HIV and other STDs: They initiated sex during early adolescence; their first sexual partners a
- Developing, implementing, and evaluating a condom promotion program targeting sexually active adolescents.
- AIDS Educ Prev. 1999 Dec;11(6):497-512. Unique Identifier : AIDSLINE MED/20155313
- Alstead M; Campsmith M; Halley CS; Hartfield K; Goldbaum G; Wood RW; Public Health-Seattle & King County HIV/AIDS Program, Seattle, WA; 98104, USA.
- This article describes the development, implementation, and evaluation of the Condom Campaign, a 1995 HIV prevention program promoting condom use among sexually active adolescents in three King County, Washington, urban communities. This program employed three main strategies: (a) mobilizing all levels of the target ca
- What high-risk women are telling us about access to primary and reproductive health care and HIV prevention services.
- AIDS Educ Prev. 1999 Dec;11(6):513-24. Unique Identifier : AIDSLINE MED/20155314
- Oliva G; Rienks J; McDermid M; University of California, San Francisco, 94118, USA.; dyleli@itsa.ucsf.edu
- Focus group discussions on barriers to health care and attitudes toward family planning, reproductive health services, and condom use were conducted with 63 women at high risk for HIV due to their own injection drug use, sex with injection drug users, sex industry work, or a history of multiple sexually transmitted dia
- The AIDS Memorial Quilt as preventative education: a developmental analysis of the Quilt.
- AIDS Educ Prev. 1999 Dec;11(6):525-40. Unique Identifier : AIDSLINE MED/20155315
- Knaus CS; Austin EW; Education Leadership and Policy Studies, University of; Washington, Seattle 98195-3600, USA. educate@u.washington.edu
- This study consisted of a survey given to college students (N = 560) at a rural university in the Pacific Northwest. The sample was randomly assigned into four groups, following the Solomon four-group study design. The two levels of treatment included interventions consisting of a visit to the AIDS Memorial Quilt for a
- Oral health perceptions and adherence with dental treatment referrals among caregivers of children with HIV.
- Unique Identifier : AIDSLINE MED/20155316
- Broder HL; Russell SL; Varagiannis E; Reisine ST; University of Medicine and Dentistry of New Jersey, Dental; School, Newark 07103-2400, USA. Broder@umdnj.edu
- Results from a 3-year longitudinal study on the oral manifestations of AIDS (OMA) among seropositive children and their siblings indicated poor adherence with recommendations for dental treatment (Broder, Catalanotto, Reisine, & Variagiannis, 1996). The purposes of this study were to (a) to examine oral health beha
- Erythema elevatum diutinum and HIV infection: a report of five cases.
- Br J Dermatol. 1999 Aug;141(2):335-8. Unique Identifier : AIDSLINE MED/99398022
- Muratori S; Carrera C; Gorani A; Alessi E; Institute of Dermatological Sciences, University of Milan, IRCCS; Ospedale Maggiore, Via Pace 9, 20122 Milan, Italy.
- Erythema elevatum diutinum (EED) is emerging as a specific HIV-associated dermatosis, 11 cases having so far been reported in the medical literature and five patients with the disease having been seen by us during the last 4 years. As the disease is poorly known, it is easily confused with Kaposi s sarcoma or
- Failure to detect human herpesvirus type 8-DNA sequences in systemic plasmacytosis from HIV-uninfected Japanese patients [letter]
- Br J Dermatol. 1999 Aug;141(2):360-1. Unique Identifier : AIDSLINE MED/99398034
- Watanabe T; Tada Y; Nakamura K; Tsuchida T; Tamaki K
- Graft-versus-host disease-like immunophenotype and apoptotic keratinocyte death in paraneoplastic pemphigus.
- Br J Dermatol. 1999 Oct;141(4):739-46. Unique Identifier : AIDSLINE MED/20050213
- Reich K; Brinck U; Letschert M; Blaschke V; Dames K; Braess J; Wormann B; Runger TM; Neumann C; Department of Dermatology, Georg-August-University, Gottingen,; Germany. kreich@gwdg.de
- Paraneoplastic pemphigus (PP) is an autoimmune disease, which is frequently associated with non-Hodgkin s lymphoma . Autoantibodies against components of the cytoplasmic plaque of epithelial desmosomes are usually present in the sera and are believed to play a major pathogenic part
- Sezary syndrome revealed by routine blood examination [letter]
- Br J Dermatol. 1999 Oct;141(4):768-9. Unique Identifier : AIDSLINE MED/20050231
- Boulec A; Wechsler J; Delfau-Larue MH; Revuz J; Bagot M
- Human herpesvirus type 8 is not detected in cutaneous lesions of sarcoidosis [letter]
- Br J Dermatol. 1999 Oct;141(4):769. Unique Identifier : AIDSLINE MED/20050232
- Sugaya M; Nakamura K; Takahiro W; Tamaki K
- Cidofovir for the treatment of Kaposi's sarcoma in an HIV-negative homosexual man [letter]
- Br J Dermatol. 1999 Dec;141(6):1148-9. Unique Identifier : AIDSLINE MED/20184651
- Fife K; Gill J; Bourboulia D; Gazzard B; Nelson M; Bower M
- Liposomal vincristine in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial.
- Ann Oncol. 2000 Jan;11(1):69-72. Unique Identifier : AIDSLINE MED/20154980
- Sarris AH; Hagemeister F; Romaguera J; Rodriguez MA; McLaughlin P; Tsimberidou AM; Medeiros LJ; Samuels B; Pate O; Oholendt M; Kantarjian H; Burge C; Cabanillas F; Department of Lymphoma and Myeloma, University of Texas M.D.; Anderson Cancer Center, Houston, USA. asarris@notes.mdacc.tmc.edu
- OBJECTIVE: Vincristine is an active agent in lymphomas, but is often neurotoxic, and the resulting dose reductions have been associated with lower remission and survival rates in Hodgkin s disease. Liposomal vincristine (Onco-TCS) has prolonged half-life, reaches higher concentration in tumors and lymph nodes than in
- A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
- Cell Growth Differ. 1999 Dec;10(12):829-38. Unique Identifier : AIDSLINE MED/20083198
- Zhu JW; DeRyckere D; Li FX; Wan YY; DeGregori J; Department of Biochemistry, University of Colorado Health; Sciences Center, Denver 80262, USA.
- E2F transcriptional activity controls the expression of many of the genes required for G1 to S phase progression. E2F1, one member of the E2F family, plays an important role in the induction of apoptosis. We have examined the role of the E2F1 transcription factor in apoptosis during T-cell maturation in the thymus. We
- Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethy- lthy mine.
- Biochemistry. 2000 Feb 15;39(6):1427-33. Unique Identifier : AIDSLINE MED/20150417
- Sluis-Cremer N; Dmitrienko GI; Balzarini J; Camarasa MJ; Parniak MA; Lady Davis Institute for Medical Research and McGill University; AIDS Centre, Montreal, Quebec H3T 1E2, Canada.
- The nonnucleoside inhibitor binding pocket is a well-defined region in the p66 palm domain of the human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT). This binding pocket opens toward the interface of the p66/p51 heterodimer and we have investigated whether ligand binding at or near this site induces
- The NMR structure of the nucleocapsid protein from the mouse mammary tumor virus reveals unusual folding of the C-terminal zinc knuckle.
- Biochemistry. 2000 Feb 22;39(7):1604-12. Unique Identifier : AIDSLINE PDB/1DSV
- Klein DJ; Johnson PE; Zollars ES; De Guzman RN; Summers MF; Howard Hughes Medical Institute and Department of Chemistry and; Biochemistry, University of Maryland Baltimore County, Baltimore,; Maryland 21250, USA.
- The nucleocapsid protein (NC) from the mouse mammary tumor virus (MMTV) has been overexpressed in Escherichia coli and purified to homogeneity for structural studies by nuclear magnetic resonance (NMR) spectroscopy. The protein contains two copies of a conserved zinc-coordinating CCHC array or zinc knuckle motif c
- Helical interactions in the HIV-1 gp41 core reveal structural basis for the inhibitory activity of gp41 peptides.
- Biochemistry. 2000 Feb 22;39(7):1634-42. Unique Identifier : AIDSLINE PDB/1DLB
- Shu W; Liu J; Ji H; Radigen L; Jiang S; Lu M; Department of Biochemistry, Weill Medical College of Cornell; University, 1300 York Avenue, New York, New York 10021, USA.
- The HIV-1 gp41 envelope protein mediates membrane fusion that leads to virus entry into the cell. The core structure of fusion-active gp41 is a six-helix bundle in which an N-terminal three-stranded coiled coil is surrounded by a sheath of antiparallel C-terminal helices. A conserved glutamine (Gln 652) buried in this
- Activation of NF-kappa B and p38 MAP kinase is not sufficient for triggering efficient HIV gene expression in response to stress.
- Biochemistry. 2000 Feb 22;39(7):1709-15. Unique Identifier : AIDSLINE MED/20143486
- Taher MM; Oakley JD; Hershey C; Valerie K; Department of Radiation Oncology and Massey Cancer Center,; Medical College of Virginia, Virginia Commonwealth University,; Richmond, Virginia 23298-0058, USA.
- Recent studies have established an essential role for p38 MAP kinase in UV activation of human immunodeficiency virus (HIV) gene expression. However, p38 MAP kinase is not involved in activation of NF-kappa B, a key transcriptional activator of HIV gene expression, in response to UV, suggesting that NF-kappa B acts in
- The polar region consecutive to the HIV fusion peptide participates in membrane fusion.
- Biochemistry. 2000 Feb 22;39(7):1826-33. Unique Identifier : AIDSLINE MED/20143500
- Peisajovich SG; Epand RF; Pritsker M; Shai Y; Epand RM; Department of Biological Chemistry, Weizmann Institute of; Science, Rehovot 76100, Israel.
- The fusion peptide of HIV-1 gp41 is formed by the 16 N-terminal residues of the protein. This 16-amino acid peptide, in common with several other viral fusion peptides, caused a reduction in the bilayer to hexagonal phase transition temperature of dipalmitoleoylphosphatidylethanolamine (T(H)), suggesting its ability t
- Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo.
- Hum Gene Ther. 2000 Jan 20;11(2):305-21. Unique Identifier : AIDSLINE MED/20143037
- Kim JJ; Yang JS; Lee DJ; Wilson DM; Nottingham LK; Morrison L; Tsai A; Oh J; Dang K; Dentchev T; Agadjanyan MG; Sin JI; Chalian AA; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.
- Studies have indicated that professional APCs in the periphery, such as dendritic cells and macrophages, play an important role in initiating DNA vaccine-specific immune responses. To engineer the immune response induced by DNA vaccines in vivo we investigated the modulatory effects of codelivering growth factor genes
- Lentiviral and murine retroviral transduction of T cells for expression of human CD40 ligand.
- Hum Gene Ther. 2000 Jan 20;11(2):323-32. Unique Identifier : AIDSLINE MED/20143038
- Barry SC; Seppen J; Ramesh N; Foster JL; Seyama K; Ochs HD; Garcia JV; Osborne WR; Department of Pediatrics, University of Washington, Seattle; 98195, USA.
- Efficient transduction of primary human T cells is an important goal toward treating a number of genetic defects. Patient T cells could be harvested by leukapheresis, transduced, and returned to the donor. A wide range of secreted or cell surface therapeutic proteins may be delivered in this way. The ability to produc
- Anti-human immunodeficiency virus type 1 gene therapy in human central nervous system-based cells: an initial approach against a potential viral reservoir.
- Hum Gene Ther. 2000 Jan 20;11(2):347-59. Unique Identifier : AIDSLINE MED/20143040
- Mukhtar M; Duke H; BouHamdan M; Pomerantz RJ; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, PA 19107, USA.
- Studies have demonstrated that human immunodeficiency virus type 1 (HIV-1) infection of central nervous system (CNS)-based cells in vivo results in a series of devastating clinical conditions collectively termed acquired immune deficiency syndrome (AIDS) dementia complex (ADC). Gen
- Genitourinary medicine and sexually transmitted infections in the 21st century.
- Int J STD AIDS. 2000 Jan;11(1):1-7. Unique Identifier : AIDSLINE MED/20129355
- Thin RN; Department of Genitourinary Medicine, Guy's & St Thomas Hospital; Trust, London, UK.
- Psychosocial impact of type-specific herpes simplex serological testing on asymptomatic sexual health clinic attendees.
- Int J STD AIDS. 2000 Jan;11(1):15-20. Unique Identifier : AIDSLINE MED/20129357
- Smith A; Denham I; Keogh L; Jacobs D; McHarg V; Marceglia A; Wood V; Australian Research Centre in Sex, Health & Society, La Trobe; University, Melbourne, Australia. Anthony.Smith@LATROBE.EDU.AU
- The usefulness of type-specific testing for herpes simplex virus type 2 (HSV-2) is much debated with proponents arguing for likely change in the sexual behaviour of asymptomatic carriers and opponents suggesting that testing may have significant adverse psychological impact while not promoting behaviour change. In the
- Going underground and going after women: trends in sexual risk behaviour among gold miners in South Africa.
- Int J STD AIDS. 2000 Jan;11(1):21-6. Unique Identifier : AIDSLINE MED/20129358
- Meekers D; Research Division, Population Services International, Washington,; DC 20036, USA. dmeekers@psiwash.org
- This paper examines trends in risk behaviour among South African gold miners, a population with an estimated HIV prevalence of 10-20%. The study is based on a 1995 and 1997 survey of a random sample gold miners in the town of Welkom, South Africa. The results show that the percentage of miners who perceived they were
- The effect of modest monetary incentives on follow-up rates in sexually transmitted disease studies.
- Int J STD AIDS. 2000 Jan;11(1):27-30. Unique Identifier : AIDSLINE MED/20129359
- Kissinger P; Kopicko JJ; Myers L; Wustrack S; Elkins W; Farley TA; Martin D; Tulane University, School of Public Health and Tropical Medicine,; LA, USA.
- The purpose of the study was to determine if follow-up rates in sexually transmitted disease (STD) research could be improved by offering modest monetary incentives. Women aged 14-34, infected with Chlamydia trachomatis, and enrolled in either of 2 studies between May 1995 and January 1999 were included. Beginning in
- Seronegative HIV-2 carriers in India.
- Int J STD AIDS. 2000 Jan;11(1):31-7. Unique Identifier : AIDSLINE MED/20129360
- Kageyama S; Maniar JK; Iwasaki M; Zhang J; Saple DG; Tsuchie H; Tanabe-Tochikura A; Taniguchi K; Shiraki K; Kurimura T; Department of Virology, Toyama Medical and Pharmaceutical; University, Japan.
- The discordant cases of seronegative, but culture and proviral HIV-2 DNA positive were found in Mumbai, India . This was corroborated by the successful isolation of HIV-2-RNA in culture medium, HIV-2 cDNA sequence determination and the detection of the antigen. The sequence of the is
- Secondary HIV transmission rates in a mixed-gender sample.
- Int J STD AIDS. 2000 Jan;11(1):38-44. Unique Identifier : AIDSLINE MED/20129361
- Pinkerton SD; Abramson PR; Kalichman SC; Catz SL; Johnson-Masotti AP; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee, USA. pinkrton@mcw.edu
- Information about the sexual behaviour of HIV-infected individuals is needed to predict the course of the sexually transmitted HIV epidemic in the US. The present study provides model-based estimates of the secondary transmission rate (i.e. the number of infections expected among the sex partners of already infected i
- Disease prevalence in women attending the STD clinic in Mumbai (formerly Bombay), India.
- Unique Identifier : AIDSLINE MED/20129362
- Divekar AA; Gogate AS; Shivkar LK; Gogate S; Badhwar VR
- Our objectives were to determine the prevalence of Neisseria gonorrhoeae and its association with other STD causing organisms. Three hundred and thirty-six consecutive women (female sex workers (FSWs) and married contacts), attending a sexually transmitted disease (STD) clinic in Mumbai, were screened for N. gonorrhoe
- Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India.
- Int J STD AIDS. 2000 Jan;11(1):49-51. Unique Identifier : AIDSLINE MED/20129363
- Srikanth P; Castillo RC; Sridharan G; John TJ; Zachariah A; Mathai D; Schwartz DH; Department of Clinical Virology, Christian Medical College; Hospital, Vellore, India.
- Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in sout
- The impact of zidovudine on dementia-free survival in a population of HIV-positive men and women on antiretroviral therapy.
- Int J STD AIDS. 2000 Jan;11(1):52-6. Unique Identifier : AIDSLINE MED/20129364
- Cornelisse PG; Montessori V; Yip B; Craib KJ; O'Shaughnessy MV; Montaner JS; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.
- Our objective was to characterize the effect of zidovudine therapy on AIDS dementia complex (dementia) free survival among HIV-infected men and women in a population-based cohort with free access to antiretroviral therapy in the province of British Columbia. Time to diagnosis of de
- Perceived compliance with AZT dosing among a sample of African-American drug users.
- Int J STD AIDS. 2000 Jan;11(1):57-63. Unique Identifier : AIDSLINE MED/20129365
- Williams M; Bowen A; Ross M; Freeman R; Elwood W; Center for Health Promotion Research and Development, School of; Public Health, University of Texas-Houston, 77225, USA.; mwilliams@sph.uth.tmc.edu
- The purpose of this report was to present findings from a pilot study conducted to explore the associations between sociodemographic, drug use, and health belief factors and perceived compliance with zidovudine ( AZT ) among African-American drug users.
- Pneumocystis carinii pneumonia following discontinuation of primary prophylaxis despite highly active antiretroviral therapy.
- Int J STD AIDS. 2000 Jan;11(1):64-5. Unique Identifier : AIDSLINE MED/20129366
- Mammen-Tobin A; Monteiro EF; Department of Genitourinary Medicine, Leeds General Infirmary,; UK.
- Sexually transmitted infections and cervical neoplasia [letter]
- Int J STD AIDS. 2000 Jan;11(1):67-8. Unique Identifier : AIDSLINE MED/20129367
- la Ruche G; Faye-Kette H; Bankole HS; Dabis F
- Update on the experimental human model for chancroid infection [letter]
- Int J STD AIDS. 2000 Jan;11(1):68-9. Unique Identifier : AIDSLINE MED/20129368
- Lewis DA
- Ciprofloxacin-resistant gonorrhoea [letter]
- Int J STD AIDS. 2000 Jan;11(1):69. Unique Identifier : AIDSLINE MED/20129369
- Wildman G; Rajamanoharan S; Tang A
- Antibiotic prophylaxis and suction termination of pregnancy [letter]
- Int J STD AIDS. 2000 Jan;11(1):69-70. Unique Identifier : AIDSLINE MED/20129370
- Singh G
- Termination of pregnancy, chlamydia and contact tracing [letter]
- Int J STD AIDS. 2000 Jan;11(1):70. Unique Identifier : AIDSLINE MED/20129371
- Evans A; Carlin E; Slack R; Allaby M
- A retrospective study of neutropenia in HIV disease.
- Int J STD AIDS. 2000 Jan;11(1):8-14. Unique Identifier : AIDSLINE MED/20129356
- Moore DA; Sullivan A; Hilstead P; Gazzard BG; Kobler Clinic, Chelsea and Westminster Hospital, London, UK.
- In aiming to define the characteristics of HIV-infected subjects developing neutropenia and describe the causes, features and effects of neutropenia we undertook a retrospective study in a dedicated HIV unit in London, UK. Two hundred and forty-four patients with documented neutropenia, defined as absolute neutrophil
- [Herpetic tracheobronchitis in a patient with the acquired immunodeficiency syndrome (letter)]
- An Med Interna. 1999 Dec;16(12):656-7. Unique Identifier : AIDSLINE MED/20151340
- Abellan Martinez J; Herraez Herrera PL; Toral Vazquez D; Sanz Garcia RM; Guillen Camargo V; Lizasoain Hernandez M; Lopez-Rios F
- KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
- Blood. 2000 Feb 15;95(4):1151-7. Unique Identifier : AIDSLINE MED/20129565
- Stine JT; Wood C; Hill M; Epp A; Raport CJ; Schweickart VL; Endo Y; Sasaki T; Simmons G; Boshoff C; Clapham P; Chang Y; Moore P; Gray PW; Chantry D; ICOS Corporation, Bothell, WA 98021, USA.
- Kaposi s sarcoma-associated herpesvirus (KSHV) encodes 3 genes that are homologous to cellular chemokines. vMIP-III, the product of open reading frame K4.1, is the most distantly related to human chemokines and has yet to be characterized. We have examined the interaction of vMIP-III with chemokine receptors, its expr
- Limited expression of R5-tropic HIV-1 in CCR5-positive type 1-polarized T cells explained by their ability to produce RANTES, MIP-1alpha, and MIP-1beta.
- Blood. 2000 Feb 15;95(4):1167-74. Unique Identifier : AIDSLINE MED/20129567
- Annunziato F; Galli G; Nappi F; Cosmi L; Manetti R; Maggi E; Ensoli B; Romagnani S; Department of Internal Medicine, Section of Immunoallergology and; Respiratory Disorders, University of Florence, Florence, Italy.
- Human T helper (Th) cells (Th1- or Th2-oriented memory T cells as well as Th1- or Th2-polarized naive T cells) were infected in vitro with an R5-tropic HIV-1 strain (BaL) and assessed for their profile of cytokine production, CCR5 receptor expression, and HIV-1 p24 antigen (p24 Ag) production. Higher p24 Ag production
- Targeted disruption of stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response.
- Blood. 2000 Feb 15;95(4):1249-57. Unique Identifier : AIDSLINE MED/20129578
- Wang LH; Yang XY; Kirken RA; Resau JH; Farrar WL; Cytokine Molecular Mechanisms Section, Laboratory of Molecular; Immunoregulation, Division of Basic Sciences, Frederick, MD, USA.
- The transcription factor, signal transducer and activator of transcription (Stat) 6, regulates T(H)2-lymphocyte activity by controlling the expression and responsiveness to interleukin (IL)-4, which plays a key role in numerous allergic maladies. Therefore, we sought to use a phosphorothiolate cis-element decoy to tar
- Stimulation of cytotoxic T cells against idiotype immunoglobulin of malignant lymphoma with protein-pulsed or idiotype-transduced dendritic cells.
- Blood. 2000 Feb 15;95(4):1342-9. Unique Identifier : AIDSLINE MED/20129590
- Osterroth F; Garbe A; Fisch P; Veelken H; Departments of Hematology/Oncology and Pathology, Freiburg; University Medical Center, Freiburg, Germany.
- Because of their hypervariable regions and somatic mutations, the antigen receptor molecules of lymphomas (idiotypes) are tumor-specific antigens and attractive targets for antilymphoma immunotherapy. For the optimal induction of human idiotype-specific cytotoxic T cells (CTL), idiotype was presented to CD8(+) periphe
- Thymocyte development past the CD4(+)CD8(+) stage requires an active p38 mitogen-activated protein kinase.
- Blood. 2000 Feb 15;95(4):1356-61. Unique Identifier : AIDSLINE MED/20129592
- Fernandez E; Structural Biology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Rockville,; MD, USA. efernamdez@cbm.uam.es
- Activation of the p38 mitogen-activated protein kinase (MAPK) pathway is important for some T-cell functions, but its role in intrathymic development is unclear. To investigate the function of p38 MAPK during the late stages of thymocyte differentiation, pharmacologic and genetic manipulations were used to inhibit p38
- Migration of activated CD8(+) T lymphocytes to sites of viral infection does not require endothelial selectins.
- Blood. 2000 Feb 15;95(4):1362-9. Unique Identifier : AIDSLINE MED/20129593
- Bartholdy C; Marker O; Thomsen AR; Institute of Medical Microbiology and Immunology, University of; Copenhagen, Denmark.
- Using mice deficient of E-selectin and E/P-selectin, we have studied the requirement for endothelial selectins in extravasation of leukocytes at sites of viral infection, with major emphasis on the recruitment of virus-specific T(C)1 cells. Lymphocytic choriomeningitis virus (LCMV)-induced meningitis was used as our p
- Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes.
- Blood. 2000 Feb 15;95(4):1386-92. Unique Identifier : AIDSLINE MED/20129596
- Hanon E; Hall S; Taylor GP; Saito M; Davis R; Tanaka Y; Usuku K; Osame M; Weber JN; Bangham CR; Department of Immunology and Genito-Urinary Medicine and; Communicable Diseases, Imperial College School of Medicine, St; Mary's Campus, London, United Kingdom.
- The role of the cellular immune response in human T-cell leukemia virus type I (HTLV-I) infection is not fully understood. A persistently activated cytotoxic T lymphocyte (CTL) response to HTLV-I is found in the majority of infected individuals. However, it remains unclear whether this CTL response is protective or ca
- Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens.
- Blood. 2000 Feb 15;95(4):1393-9. Unique Identifier : AIDSLINE MED/20129597
- Cunto-Amesty G; Przybylski G; Honczarenko M; Monroe JG; Silberstein LE; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA 19104-6082,; USA.
- Chronic B-cell stimulation may be a predisposing event in the early pathogenesis of the acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL). ARL-derived immunoglobulin (Ig) genes are significantly diversified from germline, suggesting that antigenic stimulation via Ig receptors may occur prior to malignan
- HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma.
- Blood. 2000 Feb 15;95(4):1406-12. Unique Identifier : AIDSLINE MED/20129599
- Dupin N; Diss TL; Kellam P; Tulliez M; Du MQ; Sicard D; Weiss RA; Isaacson PG; Boshoff C; Departments of Oncology, Molecular Pathology and Histopathology,; University College London, UK.
- Castleman disease (CD) is a lymphoproliferative disorder of unknown etiology that is associated with the development of secondary tumors, including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi s sarcoma-associated herpesvirus) sequences have been described in some cases of multicentric Castleman disease (MCD).
- Confidentiality. 6: HIV/AIDS patients and the duty of confidentiality.
- Br J Nurs. 1999 Jul 22-Aug 11;8(14):961-2. Unique Identifier : AIDSLINE MED/20176362
- Dimond B; University of Glamorgan.
- Recent developments in CD8+ T-lymphocyte memory research.
- J Formos Med Assoc. 1999 Nov;98(11):736-9. Unique Identifier : AIDSLINE MED/20169867
- Kung JT; Institute of Molecular Biology, Academia Sinica, Nankang, Taipei,; Taiwan.
- Appropriately activated CD8+ T cells differentiate into cytotoxic effectors capable of eliminating cancer cells and virally infected cells. Successful generation and maintenance of effective CD8+ T-cell memory, through either natural infection or through vaccination, establishes long-term protection against various pa
- Varicella pneumonia complicated by acute respiratory distress syndrome in an adult.
- J Formos Med Assoc. 1999 Nov;98(11):778-82. Unique Identifier : AIDSLINE MED/20169874
- Chou DW; Lee CH; Chen CW; Chang HY; Hsiue TR; Department of Medicine, National Cheng Kung University, College; of Medicine, Tainan, Taiwan.
- Primary varicella infection is uncommon in adults, but carries a higher rate of morbidity and mortality than in children. Pneumonia is the most common complication of primary varicella infection in adults. However, varicella pneumonia complicated with acute respiratory distress syndrome (ARDS) is very rare. We report
- South African minister accused of human rights abuse [news]
- BMJ. 2000 Jan 29;320(7230):271. Unique Identifier : AIDSLINE MED/20115289
- Sidley P
- Getting HIV/AIDS accepted on the political agenda [letter]
- BMJ. 2000 Feb 19;320(7233):516. Unique Identifier : AIDSLINE MED/20143638
- O'Farrell N
- Latest developments in gene transfer technology: achievements, perspectives, and controversies over therapeutic applications.
- Stem Cells. 2000;18(1):19-39. Unique Identifier : AIDSLINE MED/20125211
- Romano G; Michell P; Pacilio C; Giordano A; Kimmel Cancer Institute, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.; Gaetano.Romano@mail.tju.edu
- Over the last decade, more than 300 phase I and phase II gene-based clinical trials have been conducted worldwide for the treatment of cancer and monogenic disorders. Lately, these trials have been extended to the treatment of AIDS and, to a lesser extent, cardiovascular diseases. There are 27 currently active gene th
- [Combination of phosphazide and crixivan inhibit replication of HIV-1 strains that are resistant to azidothymidine]
- Dokl Akad Nauk. 1999 Dec;369(6):847-9. Unique Identifier : AIDSLINE MED/20151672
- Selimova LM; Kraevskii AA; Galegov GA
- Promptly reported diagnoses of HIV infection reached highest UK total in 1999.
- Commun Dis Rep CDR Wkly. 2000 Jan 28;10(4):29, 32. Unique Identifier : AIDSLINE MED/20163032
- AIDS and HIV infection in the United Kingdom: monthly report.
- Commun Dis Rep CDR Wkly. 2000 Jan 28;10(4):37-40. Unique Identifier : AIDSLINE MED/20163033
- Different serum interleukin-12 and sCD30 levels in food- and pollen-sensitized children.
- Pediatr Allergy Immunol. 1999 Nov;10(4):235-40. Unique Identifier : AIDSLINE MED/20142186
- Blanco Quiros A; Arranz E; Hoyos C; Carrasco JA; Andion R; Department of Paediatrics and Immunology, University of; Valladolid, Spain. ablanco@ped.uva.es
- It has been proposed that a down-regulation of interleukin (IL)-12 and interferon (IFN)-gamma might be related to susceptibility to allergy in early life. The aim of this study was to assess serum IL-12 levels in food-sensitized and pollen-sensitized children and to compare these with another activation marker, sCD30.
- [Mitochondrial disfunction and perinatal exposure to antiretroviral nucleoside analogues]
- Arch Pediatr. 2000 Jan;7(1):7-9. Unique Identifier : AIDSLINE MED/20133258
- Blanche S; Tardieu M; Rustin P
- [Accidental HIV exposure of children through injury with discarded syringes]
- Arch Pediatr. 2000 Jan;7(1):83-6. Unique Identifier : AIDSLINE MED/20133271
- Blanche S; Unite d'immunologie-hematologie pediatrique, hopital; Necker-Enfants-Malades, Paris, France.
- Potential HIV exposure through injury with discarded syringes is a frequent event among children. Although no case of HIV infection has been reported so far in this context, an antiretroviral prophylaxis is generally proposed. Such treatment is extrapolated from consensus for management of exposed health care workers.
- [Sensitivity of screening kits for anti-HIV antibodies. 1999 update. Retrovirus Working Group of the French Society for Blood Transfusion]
- Unique Identifier : AIDSLINE MED/20131448
- Courouce AM; Institut national de la transfusion sanguine, Paris, France.
- A comparative evaluation of the sensitivity of anti-HIV screening assays has been recently performed with a selected panel of 65 samples which included HIV1 group M (per-seroconversions, seroconversions and seropositives infected with genotypes A, B, C, D, E), HIV1 group O and HIV2. The results obtained with the 21 EL
- Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes.
- Eur J Neurosci. 2000 Jan;12(1):117-25. Unique Identifier : AIDSLINE MED/20117548
- Lazarini F; Casanova P; Tham TN; De Clercq E; Arenzana-Seisdedos F; Baleux F; Dubois-Dalcq M; Unite de Neurovirologie et Regeneration du Systeme Nerveux,; Institut Pasteur, 75724, Cedex 15, Paris, France.
- CXCR4 is the Gi protein-linked seven-transmembrane receptor for the alpha chemokine stromal cell-derived factor 1 (SDF-1), a chemoattractant for lymphocytes. This receptor is highly conserved between human and rodent. CXCR4 is also a coreceptor for entry of human immunodeficiency virus (HIV) in T cells and is expresse
- Advancing safety.
- Revolution. 1998 Summer;8(2):16-7. Unique Identifier : AIDSLINE MED/20176532
- Arnold L
- Lentiviral vectors: turning a deadly foe into a therapeutic agent.
- Gene Ther. 2000 Jan;7(1):20-3. Unique Identifier : AIDSLINE MED/20146292
- Trono D; Department of Genetics and Microbiology, Faculty of Medicine,; University of Geneva, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4,; Switzerland.
- The past 3 years have witnessed the spectacular irruption of lentiviral vectors into the limelight of the gene therapy scene. Owing to their ability to deliver transgenes in tissues that had long appeared irremediably refractory to stable genetic manipulation, lentivectors have opened fresh perspectives for the geneti
- Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer.
- Gene Ther. 2000 Jan;7(1):53-60. Unique Identifier : AIDSLINE MED/20146297
- Maruyama-Tabata H; Harada Y; Matsumura T; Satoh E; Cui F; Iwai M; Kita M; Hibi S; Imanishi J; Sawada T; Mazda O; Department of Pediatrics, Kyoto Prefectural University of; Medicine, Kamikyo, Kyoto, Japan.
- This study demonstrates in vivo effectiveness of a nonviral vector system, Epstein-Barr virus (EBV)-based plasmid vector coupled with polyamidoamine (PAMAM) dendrimer (EBV/polyplex), in suicide gene therapy of cancer. The EBV-based vector is a plasmid vector containing EBV nuclear antigen 1 (EBNA1) gene and oriP from
- Efficient transduction of mature CD83+ dendritic cells using recombinant adenovirus suppressed T cell stimulatory capacity.
- Gene Ther. 2000 Feb;7(3):249-54. Unique Identifier : AIDSLINE MED/20161131
- Jonuleit H; Tuting T; Steitz J; Bruck J; Giesecke A; Steinbrink K; Knop J; Enk AH; Department of Dermatology, J Gutenberg-University,; Langenbeckstrasse 1, D-55101 Mainz, Germany.
- We have developed a culture method for the foreign serum-free generation of highly immunostimulatory, CD83+ human dendritic cells (DC). In this study, we evaluated the feasibility and consequences of endogenously expressing antigens in mature DC using adenoviral vectors. Transduction of DC with Ad-EGFP demonstrated en
- Expression of human Wiskott-Aldrich syndrome protein in patients' cells leads to partial correction of a phenotypic abnormality of cell surface glycoproteins.
- Gene Ther. 2000 Feb;7(4):314-20. Unique Identifier : AIDSLINE MED/20161141
- Huang MM; Tsuboi S; Wong A; Yu XJ; Oh-Eda M; Derry JM; Francke U; Fukuda M; Weinberg KI; Kohn DB; Division of Research Immunology/Bone Marrow Transplantation,; Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
- The Wiskott-Aldrich syndrome (WAS) is an uncommon X-linked recessive disease characterized by thrombocytopenia, eczema and immunodeficiency. The biochemical defect of this disorder primarily affects cells derived from bone marrow. To understand better the molecular mechanisms underlying this disease and to evaluate th
- Inhibition of HIV-1 replication in chronically infected cell lines and peripheral blood mononuclear cells by retrovirus-mediated antitat gene transfer.
- Gene Ther. 2000 Feb;7(4):321-8. Unique Identifier : AIDSLINE MED/20161142
- Li Y; Starr SE; Lisziewicz J; Ho WZ; Division of Immunologic and Infectious Diseases, Joseph Stokes Jr; Research Institute of The Children's Hospital of Philadelphia,; Department of Pediatrics, University of Pennsylvania Medical; School, Philadelphia, PA 19104, USA.
- Among potential genetic targets for intervention in the HIV-1 life cycle, the tat gene product is a key target. We investigated the ability of an antitat gene to inhibit HIV-1 activation and replication in chronically infected promonocyte (U1) and T cell (ACH-2) lines in vitro. U1 and ACH-2 cells were transduced with
- Characterization of the cytokine network at a single cell level in mice with collagen-induced arthritis using a dual color ELISPOT assay.
- J Interferon Cytokine Res. 2000 Jan;20(1):55-61. Unique Identifier : AIDSLINE MED/20134112
- Okamoto Y; Gotoh Y; Tokui H; Mizuno A; Kobayashi Y; Nishida M; Department of Clinical Pharmacy, Faculty of Pharmacy, Meijo; University, Nagoya, Japan. yokamoto@meijo-u.ac.jp
- Collagen-induced arthritis (CIA) in mice has been classified as a Thl-mediated disease. However, most evidence for this has been obtained by indirect experiments; for example, the administration of neutralizing anti-interferon-gamma (IFN-gamma) antibody reduced the severity of arthritis. To obtain direct evidence abou
- The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice.
- J Interferon Cytokine Res. 2000 Jan;20(1):63-77. Unique Identifier : AIDSLINE MED/20134113
- Lehmann J; Enssle KH; Lehmann I; Emmendorfer A; Lohmann-Matthes ML; Fraunhofer Institute for Toxicology and Aerosolresearch Hannover,; Department of Immunobiology, Germany. Lehj@medizin.uni-leipzig.de
- The immune response against Leishmania donovani infection has been investigated in one resistant mouse strain (C3H/HeJ) and three susceptible mouse strains (C57BL/6, BALB/c, and B10D2/n). In order to correlate the strain-specific course of infection with the individual T cell response phenotype, the ex vivo cytokine s
- Orthodontic movement induces high numbers of cells expressing IFN-gamma at mRNA and protein levels.
- Unique Identifier : AIDSLINE MED/20134107
- Alhashimi N; Frithiof L; Brudvik P; Bakhiet M
- Cytokines are important signaling proteins that are liberated during immune challenges and exhibit many modulatory activities. However, their role in periodontal modeling during orthodontic tooth movement is not fully understood. The aim of this study was to analyze effects of mechanical force during orthodontic tooth
- Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response, whereas susceptibility is associated with absence of IFN-gamma production.
- Unique Identifier : AIDSLINE MED/20134115
- Kashino SS; Fazioli RA; Cafalli-Favati C; Meloni-Bruneri LH; Vaz CA; Burger E; Singer LM; Calich VL
- The secretion of interferon-gamma (IFN-gamma), interleukin-2 ( IL-2 ), IL-4, IL-5, and IL-10 by antigen-stimulated lymph node cells, eosinophil maturation, and the antibody isotypes produced were examined during intraperitoneal infection of susceptible (B10.A) and resist
- The target plot: a new way of displaying the performance of a screening test.
- J Med Screen. 1999;6(4):195-9. Unique Identifier : AIDSLINE MED/20157454
- Wald NJ; Watt HC; Department of Environmental and Preventive Medicine, Wolfson; Institute of Preventive Medicine, St Bartholomew's and the Royal; London School of Medicine and Dentistry, UK.
- OBJECTIVES: To produce a graphical method to represent the performance of a screening test that illustrates the prevalence of the disorder being screened for, as well as its discriminatory potential. CONCEPT: A target plot was constructed in which the risk of the disorder is represented by a series of concentric circl
- Human leptin enhances activation and proliferation of human circulating T lymphocytes.
- Unique Identifier : AIDSLINE MED/20141139
- Martin-Romero C; Santos-Alvarez J; Goberna R; Sanchez-Margalet V
- Leptin is an adipocyte-secreted hormone that centrally regulates weight control. However, leptin receptor is expressed not only in the central nervous system, but also in other systems such as reproductive and hematopoietic tissues. Human leptin has previously been shown to enhance cytokine production by murine perito
- Macrophage-derived nitric oxide inhibits the proliferation of activated T helper cells and is induced during antigenic stimulation of resting T cells.
- Cell Immunol. 2000 Jan 10;199(1):43-9. Unique Identifier : AIDSLINE MED/20141142
- van der Veen RC; Dietlin TA; Dixon Gray J; Gilmore W; Department of Neurology, University of Southern California School; of Medicine, Los Angeles, California 90033, USA.
- To examine how macrophage-derived nitric oxide (NO) affects T helper (Th) cell activity, T cell clones representing Th1 and Th2 subsets were activated before exposure to stimulated peritoneal macrophages or microglia. Both Th subsets were similarly sensitive to inhibition by NO, indicating that macrophage-derived NO r
- Education of medical students and house staff to prevent hazardous occupational exposure.
- CMAJ. 2000 Feb 8;162(3):344-5. Unique Identifier : AIDSLINE MED/20157980
- Doig C; Division of Critical Care, University of Calgary, Alta.; cdoig@ucalgary.ca
- Recent advances in the therapy and prevention of CMV infections.
- J Clin Virol. 2000 Feb;16(1):25-40. Unique Identifier : AIDSLINE MED/20142931
- Nichols WG; Boeckh M; Program in Infectious Diseases, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109-4417, USA.
- The introduction of highly active antiretroviral therapy (HAART) for HIV has had a major impact on the treatment of CMV disease in HIV-infected individuals. There is mounting evidence that in patients with CMV retinitis who have a sustained response to HAART, CM
- Rates and risk factors for discontinuation of rifampicin.
- Int J Tuberc Lung Dis. 2000 Feb;4(2):118-22. Unique Identifier : AIDSLINE MED/20155781
- Cook SV; Fujiwara PI; Frieden TR; New York City Department of Health, Bureau of Tuberculosis; Control, New York 10013, USA.
- SETTING: All patients with culture-confirmed, rifampin-susceptible Mycobacterium tuberculosis diagnosed during a 20-month period in New York City, who were started on a rifampin-containing regimen and received > or =60 days of treatment. OBJECTIVE: To identify rates of and reasons for rifampin discontinuation. DESIGN:
- Lymph node biopsies in HIV-infected and non-infected children with persistent lung disease.
- Unique Identifier : AIDSLINE MED/20155784
- Jeena PM; Coovadia HM; Hadley LG; Wiersma R; Grant H; Chrystal V
- OBJECTIVE: The diagnosis of opportunistic infections in children with persistent lung disease (PLD) who are infected with the human immunodeficiency virus (HIV) is difficult to establish, especially in resource-poor countries. Lymphadenopathy is a frequent associated clinical finding among these children. We evaluated
- Mycobacterium tuberculosis lipid antigens: use of multi-antigen based enzyme immunoassay for free and complex dissociated antibodies.
- Int J Tuberc Lung Dis. 2000 Feb;4(2):161-7. Unique Identifier : AIDSLINE MED/20155787
- Harrington JJ 3rd; Ho JL; Lapa e Silva JR; Conde MB; Kritski AL; Fonseca LS; Saad MH; Cornell University Medical College, Ithaca, New York, USA.
- OBJECTIVE: To test the sensitivity and specificity of four lipid antigens of Mycobacterium tuberculosis: BDA-TDA, DAT, SL-I, and PIMs, adsorbed in the same microplate well, to detect reactive IgG by enzyme-immunoassay (EIA) from plain serum (MA-EIA) and dissociated immune complexes (ICMA-EIA). DESIGN: IgG antibodies a
- A review of the diagnosis and treatment of smear-negative pulmonary tuberculosis.
- Unique Identifier : AIDSLINE MED/20155778
- Colebunders R; Bastian I
- Recommendations on the management of smear-negative pulmonary tuberculosis (TB) are still based on the behaviour of this disease in populations unaffected by the human immunodeficiency virus (HIV). Studies prior to the HIV epidemic estimated that there were 1.22 cases of smear-negative and extra-pulmonary TB for each
- Disclosure of diagnosis and planning for the future in HIV-affected families in Europe.
- Child Care Health Dev. 2000 Jan;26(1):29-40. Unique Identifier : AIDSLINE MED/20161506
- Thorne C; Newell ML; Peckham CS; Department of Epidemiology and Public Health, Institute of Child; Health, London, UK.
- Information relating to disclosure of infection status in families affected by HIV and the existence of plans for the future social care of children with infected parents was collected as part of a larger survey on clinical and psychosocial service use of these families. Parents and alternative carers of HIV-affected
- Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):1-7. Unique Identifier : AIDSLINE MED/20170323
- Fenoglio D; Li Pira G; Lozzi L; Bracci L; Saverino D; Terranova P; Bottone L; Lantero S; Megiovanni A; Merlo A; Manca F; Advanced Biotechnology Center, San Martino Hospital-University of; Genoa, Italy.
- Neutralizing antibodies and specific cytotoxic T lymphocytes (CTL) may contribute to controlling viral spread, and ideally, to virus clearance in HIV infection. Both effector mechanisms depend on specific CD4 T-helper (Th) cells. Nevertheless, HIV hypervariability facilitates appearance of escape mutants for antibodie
- Factors associated with the decline in sexually transmitted infections among HIV-positive women [letter]
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):100-2. Unique Identifier : AIDSLINE MED/20170338
- Slavinsky J 3rd; Clayton JL; Clark RA; Kissinger P
- Polymerase chain reaction monitoring of HIV-1 infection: should the CCR5 genotype be considered? [letter]
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):102-3. Unique Identifier : AIDSLINE MED/20170339
- Barlow KL; Clewley JP
- Peripheral blood lymphocyte proliferation specific for HTLV-Tax peptides in enzyme-linked immunosorbent assay-negative HTLV DNA-positive blood donors [letter]
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):103-5. Unique Identifier : AIDSLINE MED/20170340
- Zehender G; Zagliani A; De Maddalena C; Bianchi Bosisio A; Colasante C; Biasin M; Girotto M; Clerici M; Galli M
- Effects of early antiretroviral treatment on HIV-1 RNA in blood and lymphoid tissue: a randomized trial of double versus triple therapy. Swiss HIV Cohort Study.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):17-25. Unique Identifier : AIDSLINE MED/20170325
- Opravil M; Cone RW; Fischer M; Vernazza PL; Bassetti S; Lorenzi P; Bisset LR; Ott P; Huber W; Knuchel MC; Roos M; Luthy R; Weber R; Division of Infectious Diseases and Hospital Epidemiology,; University Hospital, Zurich, Switzerland.; Milos.Opravil@dim.usz.ch
- To assess the effects of early initiation of antiretroviral therapy on cell-free and cell-associated viral load in blood and lymphoid tissue, we performed a randomized, open-label, multicenter trial comparing a double (zidovudine + lamivudine) and triple (zidovudine + lamivudine +
- Emergence of dual resistance to zidovudine and lamivudine in HIV-1-infected patients treated with zidovudine plus lamivudine as initial therapy.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):26-34. Unique Identifier : AIDSLINE MED/20170326
- Kuritzkes DR; Shugarts D; Bakhtiari M; Poticha D; Johnson J; Rubin M; Gingeras TR; Kennedy M; Eron JJ; University of Colorado Health Sciences Center and Veterans; Affairs Medical Center, Denver 80262, USA.; daniel.kuritzkes@uchsc.edu
- Presence of mutations associated with resistance to zidovudine or lamivudine was determined in isolates of HIV-1 obtained after long-term follow-up of 64 infected individuals who received zidovudine, lamivudine, or both drugs as initial antiretroviral therapy. Zidovudine resistance mutations were less frequent in isol
- Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):35-43. Unique Identifier : AIDSLINE MED/20170327
- Mulligan K; Grunfeld C; Tai VW; Algren H; Pang M; Chernoff DN; Lo JC; Schambelan M; Department of Medicine, University of California, San Francisco; General Hospital, 94110, USA. kmulligan@sfghgcrc.ucsf.edu
- Although protease inhibitor (PI) therapy has improved the clinical status of patients with HIV infection, concerns have arisen that such treatment may have deleterious effects on glucose control, lipid metabolism, and body fat distribution. To determine whether initiation of PI therapy uniquely affects glucose and lip
- Prediction of imminent complications in HIV-1-infected patients by markers of lymphocyte apoptosis.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):44-51. Unique Identifier : AIDSLINE MED/20170328
- Wasmuth JC; Klein KH; Hackbarth F; Rockstroh JK; Sauerbruch T; Spengler U; Department of General Internal Medicine, University of Bonn,; Germany. j-c.wasmuth@uni-bonn.de
- OBJECTIVE: The aim of the study was to compare accepted surrogate markers of HIV disease progression with markers of lymphocyte apoptosis in their ability to predict short-term disease progression. METHODS: In all, 40 HIV-positive patients were studied prospectively and observed during follow-up for HIV-related advers
- Protective effect of CCR2-64I and not of CCR5-delta32 and SDF1-3'A in pediatric HIV-1 infection.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):52-7. Unique Identifier : AIDSLINE MED/20170329
- Mangano A; Kopka J; Batalla M; Bologna R; Sen L; Laboratorio de Biologia Celular y Retrovirus, Hospital de; Pediatria J.P. Garrahan, Buenos Aires, Argentina.
- The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3 A), CCR2-64I, and CCR5-delta32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We
- Molecular epidemiology of HIV-1 in Switzerland: evidence for a silent mutation in the C2V3 region distinguishing intravenous drug users from homosexual men. Swiss HIV Cohort Study.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):58-67. Unique Identifier : AIDSLINE +
- Stoeckli TC; Steffen-Klopfstein I; Erb P; Brown TM; Kalish ML; Division of AIDS, STD, and TB Laboratory Research, National; Center for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA. Thomas.Stoecki@uchsc.edu
- OBJECTIVES: To study the molecular epidemiology of HIV-1 strains found in Switzerland and to determine possible genetic linkages among strains sorted by risk group or geographic region. DESIGN: A cross-sectional, clinic-based survey of HIV-1 molecular sequences and linked pati
- Genetic analysis of HIV-1 samples from Spain.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):68-74. Unique Identifier : AIDSLINE +
- Casado C; Urtasun I; Martin-Walther MV; Garcia S; Rodriguez C; del Romero J; Lopez-Galindez C; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, Madrid, Spain.
- To characterize the viruses responsible for the HIV-1 epidemic in Spain , we genetically characterized 79 samples obtained from Spanish patients with different risk practices (injecting drug users and male homosexuals) in two regions (Madrid and Navarra). Genetic characterization was
- Risk factors for developing tuberculosis in HIV-1-infected adults from communities with a low or very high incidence of tuberculosis.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):75-80. Unique Identifier : AIDSLINE MED/20170332
- Wood R; Maartens G; Lombard CJ; Department of Medicine, University of Cape Town, South Africa.
- OBJECTIVE: To estimate the incidence rate of tuberculosis in HIV-1-infected adults resident in a region with a high tuberculosis prevalence and to identify clinical and laboratory parameters associated with increased risk of developing tuberculosis. METHODS: Adult patients going to the University of Cape Town HIV clin
- Neurophysiologic and immunologic abnormalities associated with feline immunodeficiency virus molecular clone FIV-PPR DNA inoculation.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):8-16. Unique Identifier : AIDSLINE MED/20170324
- Phipps AJ; Hayes KA; Buck WR; Podell M; Mathes LE; Department of Veterinary Biosciences, College of Veterinary; Medicine, The Ohio State University, Columbus, USA.
- Although direct feline immunodeficiency virus (FIV) proviral DNA inoculation has been shown to be infectious in cats, long-term studies to assess the pathogenic nature of DNA inoculation are lacking. We have recently reported that direct feline leukemia virus (FeLV) DNA inoculation resulted in infection and the develo
- When obesity is desirable: a longitudinal study of the Miami HIV-1-infected drug abusers (MIDAS) cohort.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):81-8. Unique Identifier : AIDSLINE MED/20170333
- Shor-Posner G; Campa A; Zhang G; Persaud N; Miguez-Burbano MJ; Quesada J; Fletcher MA; Page JB; Baum MK; Department of Psychiatry and Behavioral Sciences, University of; Miami School of Medicine, Florida 33136, USA.
- Despite widespread nutrient deficiencies, a substantial proportion of the MIDAS cohort exhibits obesity, which has been linked to immune dysregulation in other clinical settings. Herein, the effects of obesity on immune function, disease progression, and mortality were evaluated longitudinally in 125 HIV-1-seropositiv
- Prevalence and route of transmission of infection with a novel DNA virus (TTV), hepatitis C virus, and hepatitis G virus in patients infected with HIV.
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):89-94. Unique Identifier : AIDSLINE MED/20170334
- Puig-Basagoiti F; Cabana M; Guilera M; Gimenez-Barcons M; Sirera G; Tural C; Clotet B; Sanchez-Tapias JM; Rodes J; Saiz JC; Martinez MA; Department of Medicine, Institut d'Investigacions Biomediques; August Pi i Sunyer, Facultad de Medicina, Universidad de; Barcelona, Spain.
- OBJECTIVES: To evaluate the prevalence, route of transmission and clinical significance that current co-infection with TT virus (TTV), hepatitis C virus (HCV), and hepatitis G virus (HGV) have in HIV-1-infected patients. DESIGN: Presence of TTV, HCV, and HGV was analyzed in plasma samples from 160 HIV-1-infected patie
- Switch to an antiretroviral treatment of expected lower potency after effective highly active antiretroviral therapy (HAART) [letter]
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):95-8. Unique Identifier : AIDSLINE MED/20170335
- Manfredi R; Chiodo F
- HIV viral load and viral cultures in sexually active heterosexual men [letter]
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):98-9. Unique Identifier : AIDSLINE MED/20170336
- Buchacz K; Pan CY; van der Straten A; Hanson CV; Padian N
- Perimenopausal symptomatology among HIV-infected women at least 40 years of age [letter]
- J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):99-100. Unique Identifier : AIDSLINE MED/20170337
- Clark RA; Cohn SE; Jarek C; Craven KS; Lyons C; Jacobson M; Kamemoto L
- Dermatofibrosarcoma protuberans in two patients with acquired immunodeficiency syndrome.
- Cutis. 2000 Feb;65(2):85-8. Unique Identifier : AIDSLINE MED/20161549
- Sapadin AN; Gelfand JM; Howe KL; Phelps RG; Grand D; Rudikoff D; Department of Dermatology, Mount Sinai School of Medicine, New; York, New York 10029-6574, USA.
- Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive cutaneous tumor of intermediate malignancy. Most commonly, it arises as an asymptomatic, indurated plaque on the trunk within which protuberant nodules develop over time. We describe its occurrence in two patients with human immunodeficiency virus, a previ
- HIV-1 RNA load in needles/syringes from shooting galleries in Miami: a preliminary laboratory report.
- Unique Identifier : AIDSLINE MED/20132550
- Shapshak P; Fujimura RK; Page JB; Segal D; Rivers JE; Yang J; Shah SM; Graham G; Metsch L; Weatherby N; Chitwood DD; McCoy CB; Comprehensive Drug Research Center, University of Miami and; University of Miami School of Medicine, FL 33136, USA.; pshapsha@med.miami.edu
- We quantified HIV-1 RNA load in rinses from needles/syringes (N/S) obtained at shooting galleries in Miami and also analyzed the rinses for antibodies for viral proteins. In rinses from 36 N/S that contained visible blood, 14 (39%) had detectable amounts of HIV-1 RNA. Numbers of copies of HIV-1 RNA ranged from the det
- An approach to the medical marijuana controversy.
- Drug Alcohol Depend. 2000 Feb 1;58(1-2):3-7. Unique Identifier : AIDSLINE MED/20132534
- Hollister LE; University of Texas Medical Branch, UT Harris County Psychiatric; Center, Houston 77021, USA.
- The use of smoked marijuana as a therapeutic agent is presently a matter of considerable debate in the United States . Many people suffering from a variety of disorders maintain that it is necessary for their adequate treatment. Yet, the evidence to support claims is insufficient for
- [HIV: no virus eradication with HAART. Highly active antiretroviral therapy (news)]
- Dtsch Med Wochenschr. 2000 Feb 11;125(6):A11. Unique Identifier : AIDSLINE MED/20165702
- Bubenzer RH
- Efficacy of treatment with paromomycin, azithromycin, and nitazoxanide in a patient with disseminated cryptosporidiosis.
- Eur J Clin Microbiol Infect Dis. 1999 Dec;18(12):885-9. Unique Identifier : AIDSLINE MED/20153059
- Giacometti A; Burzacchini F; Cirioni O; Barchiesi F; Dini M; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Ospedale Umberto I, Italy. cmalinf@popcsi.unian.it
- A 24-year-old HIV-positive heterosexual woman with disseminated cryptosporidiosis was monitored from January 1998 to May 1999. During this period, consecutive stool, sputum, and bile examinations showed the constant presence of Cryptosporidium oocysts. Although the patient was repeatedly treated with oral paromomycin
- Pulmonary adiaspiromycosis in a patient with acquired immunodeficiency syndrome.
- Eur J Clin Microbiol Infect Dis. 1999 Dec;18(12):893-5. Unique Identifier : AIDSLINE MED/20153061
- Turner D; Burke M; Bashe E; Blinder S; Yust I; Department of Internal Medicine A, AIDS Center, Tel-Aviv Sourasky; Medical Center, TEl-Aviv University, Sackler Faculty of Medicine,; Israel. dntrnr@hotmail.com
- Adiaspiromycosis is a noninfectious, nonarthropod-transmitted fungal infection that occurs worldwide in lower vertebrates, especially rodents. However, humans may become accidental hosts. Reported here is a case of adiaspiromycosis of the lung in an HIV-positive, 40-year-old, bisexual man who first presented with coug
- Endogenous IL-12 synthesis is not required to prevent hyperexpression of type 2 cytokine and antibody responses.
- Eur J Immunol. 2000 Feb;30(2):347-55. Unique Identifier : AIDSLINE MED/20135836
- Rempel JD; Lewkowich IP; HayGlass KT; Department of Immunology, University of Manitoba, Winnipeg,; Canada.
- Endogenous IL-12 production is hypothesized to play an essential role preventing spontaneous expression of type 2 responses, acting as a natural inhibitor limiting development of immediate hypersensitivity. Here, IL-12-deficient p35(- / -) and p40(- / -) mice were used to examine the role of endogenous IL-12 and p40 h
- Different doses of agonistic ligand drive the maturation of functional CD4 and CD8 T cells from immature precursors.
- Eur J Immunol. 2000 Feb;30(2):371-81. Unique Identifier : AIDSLINE MED/20135839
- Lovatt M; Yang TH; Stauss HJ; Fisher AG; Merkenschlager M; Lymphocyte Development Group, MRC Clinical Sciences Centre,; Imperial College School of Medicine, London, Great Britain.
- MHC molecules are normally required for the development of thymocytes from the CD4(+)CD8(+) double-positive to the CD4 or CD8 single-positive stage. Here we show that mitogenic plant lectins can substitute for MHC molecules in driving the differentiation of phenotypically and functionally mature CD4 as well as CD8 T c
- Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3).
- Eur J Immunol. 2000 Feb;30(2):498-508. Unique Identifier : AIDSLINE MED/20135852
- Mattner F; Smiroldo S; Galbiati F; Muller M; Di Lucia P; Poliani PL; Martino G; Panina-Bordignon P; Adorini L; Roche Milano Ricerche Milano, Italy.
- 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] inhibits production of IL-12, a cytokine involved in the development of Th1 cells and in the pathogenesis of Th1-mediated autoimmune diseases. Here, we show that 1,25(OH)(2)D(3) and a non-hypercalcemic analogue are selective and potent inhibitors of Th1 development in
- CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1.
- Eur J Immunol. 2000 Feb;30(2):577-85. Unique Identifier : AIDSLINE MED/20135861
- Wallace DL; Matear PM; Davies DC; Hicks R; Lebosse C; Eyeson J; Beverley PC; Vyakarnam A; Edward Jenner Institute for Vaccine Research, Compton, GB.; diana.wallace@jenner.ac.uk
- Enrichment of a subset of CD4(+)CD45R0(+)CD7(-) T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7(+) and CD7(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7(+) cells. Several possible mechanisms that may underlie such difference
- Heat shock proteins generate beta-chemokines which function as innate adjuvants enhancing adaptive immunity.
- Eur J Immunol. 2000 Feb;30(2):594-603. Unique Identifier : AIDSLINE MED/20135863
- Lehner T; Bergmeier LA; Wang Y; Tao L; Sing M; Spallek R; van der Zee R; Department of Immunobiology, Guy's King's and St. Thomas'; Hospitals, Medical and Dental School, London, GB.; thomas.lehner@kcl.ac.uk
- Heat shock proteins (HSP) are widely distributed and highly immunogenic molecules. A novel property reported here is that stimulation with HSP70 of CD8-enriched T cells derived from naive non-human primates caused a dose-dependent increase in concentrations of the beta-chemokines RANTES, macrophage inflammatory protei
- T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB.
- Eur J Immunol. 2000 Feb;30(2):661-70. Unique Identifier : AIDSLINE MED/20135871
- Li-Weber M; Laur O; Dern K; Krammer PH; Tumor Immunology Program, German Cancer Research Center (DKFZ),; Heidelberg, Germany. m.li-weber@dkfz-heidelberg.de
- CD95(APO-1 / Fas) ligand (CD95L) gene expression is critically involved in activation-induced T cell apoptosis. We and other have previously shown that HIV-1 Tat which is essential for efficient HIV gene expression sensitizes CD95-mediated apoptosis and up-regulates CD95L expression in T cells. In the present study we
- Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1).
- Eur J Immunol. 2000 Feb;30(2):678-82. Unique Identifier : AIDSLINE MED/20135873
- Reich A; Korner H; Sedgwick JD; Pircher H; Institut fur Medizinische Mikrobiologie und Hygiene, University; of Freiburg, Germany.
- TNF receptor-ligand interactions and CD95 (Fas / APO-1) have been demonstrated to be involved in activation-induced death of mature T cells. Here, we examined the role of these molecules in the murine model of lymphocytic choriomeningitis virus (LCMV) infection using LCMV TCR transgenic (tg) mice lacking TNF, TNF rece
- Impact of in utero Th2 immunity on T cell deviation and subsequent immediate-type hypersensitivity in the neonate.
- Eur J Immunol. 2000 Feb;30(2):714-8. Unique Identifier : AIDSLINE MED/20135879
- Herz U; Ahrens B; Scheffold A; Joachim R; Radbruch A; Renz H; Hospital of the Philipps University Marburg, Dept. Clinical; Chemistry and Central Laboratory, Marburg, Germany.; herzu@post.med.uni-marburg.de
- It was the aim of this study to analyze the impact of maternal Th2 immune responses on onset and subsequent development of allergen-specific immunity and immediate-type hypersensitivity in early childhood. In a well characterized mouse model of Th2 immunity, BALB / c mice were sensitized to ovalbumin (OVA) before mati
- Functional association between the nef gene product and gag-pol region of HIV-1.
- FEBS Lett. 2000 Jan 28;466(2-3):233-8. Unique Identifier : AIDSLINE MED/20145039
- Ono T; Iwatani Y; Nishimura A; Ishimoto A; Sakai H; Department of Viral Oncology, Institute for Virus Research, Kyoto; University, Japan.
- Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV-1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions o
- Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women.
- Hepatology. 2000 Mar;31(3):751-5. Unique Identifier : AIDSLINE MED/20172029
- Conte D; Fraquelli M; Prati D; Colucci A; Minola E; Cattedra di Gastroenterologia, IRCCS Ospedale Maggiore, Milan,; Italy. Dario.Conte@unimi.it
- The prevalence and natural course of chronic hepatitis C virus (HCV) infection was evaluated in 15,250 consecutive pregnant women. The rate of HCV vertical and perinatal transmission was also assessed. The presence of anti-HCV was tested by means of EIA III and confirmed by recombinant immunoblot assay III. Alanine tr
- Inhibition of immunoglobulin E response to Japanese cedar pollen allergen (Cry j 1) in mice by DNA immunization: different outcomes dependent on the plasmid DNA inoculation method.
- Immunology. 2000 Feb;99(2):179-86. Unique Identifier : AIDSLINE MED/20157072
- Toda M; Sato H; Takebe Y; Taniguchi Y; Saito S; Inouye S; Takemori T; Sakaguchi M; Department of Immunology, AIDS Research Center and Infectious; Disease Surveillance Center, National Institute of Infectious; Diseases, Tokyo, Japan.
- To develop a new immunotherapy for Japanese cedar (Cryptomeria japonica; CJ) pollinosis, we evaluated the use of DNA immunization by inoculating mice with plasmid DNA encoding Cry j 1 as a CJ pollen major allergen (pCACJ1). Repeated intramuscular (i.m.) inoculation of BALB/c mice with pCACJ1 produced anti-Cry j 1 anti
- In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B.
- Immunology. 2000 Feb;99(2):243-8. Unique Identifier : AIDSLINE MED/20157081
- Lee MH; Kataoka T; Honjo N; Magae J; Nagai K; Department of Bioengineering, Tokyo Institute of Technology, 4259; Nagatsuta-cho, Midori-ku, Yokohama, Japan.
- Prodigiosin (PrG) 25-C and concanamycin B (CMB) are immunosuppressants that specifically inhibit the induction of cytotoxic T cells (CTL) without affecting the function of B cells and helper T cells in vivo. Both compounds inhibit acidification of intracellular organelles and induce destruction of cytotoxic granules a
- Characterization and role in experimental systemic lupus erythematosus of T-cell lines specific to peptides based on complementarity-determining region-1 and complementarity-determining region-3 of a pathogenic anti-DNA monoclonal antibody.
- Immunology. 2000 Feb;99(2):257-65. Unique Identifier : AIDSLINE MED/20157083
- Brosh N; Eilat E; Zinger H; Mozes E; Department of Immunology, The Weizmann Institute of Science,; Rehovot, Israel.
- Peptides based on the complementarity-determining region 1 (CDR1) and CDR3 of an anti-DNA monoclonal antibody (mAb) carrying the 16/6 idiotype (Id) were shown to induce experimental systemic lupus erythematosus (SLE) in susceptible mouse strains. In the present study, T-cell lines specific to the pCDR1 and pCDR3 pepti
- Human B-cell lines constitutively express and secrete interleukin-16.
- Immunology. 2000 Feb;99(2):266-71. Unique Identifier : AIDSLINE MED/20157084
- Sharma V; Sparks JL; Vail JD; Laboratory of Cytokine Research, Department of Biology,; University of West Florida, Pensacola, FL 32514, USA.
- Interleukin-16 (IL-16), produced by activated CD8+ T lymphocytes, is inhibitory to human immunodeficiency virus-1 (HIV-1) replication. In an attempt to determine whether human B cells express and secrete IL-16, a wide panel of B-cell lines derived from patients with acquired immune deficiency syndrome (AIDS)-associate
- CD40-CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1beta production by monocytes.
- Immunology. 2000 Feb;99(2):279-86. Unique Identifier : AIDSLINE MED/20157086
- Ribbens C; Dayer JM; Chizzolini C; Division of Immunology and Allergy, Department of Internal; Medicine, University Hospital, Geneva, Switzerland.
- To investigate whether antigen-independent, interleukin-2 ( IL-2 ) or IL-15 activation of polarized T helper (Th) cells would result in contact-dependent activation of monocytes, living Th1 and Th2 cell clones were co-cultured with THP-1 cells or fresh peripheral blood m
- Studies on delayed systemic effects of ultraviolet B radiation on the induction of contact hypersensitivity, 3. Dendritic cells from secondary lymphoid organs are deficient in interleukin-12 production and capacity to promote activation and differentiation of T helper type 1 cells.
- Immunology. 2000 Feb;99(2):296-304. Unique Identifier : AIDSLINE MED/20157088
- Kitazawa T; Streilein JW; The Schepens Eye Research Institute & Department of Dermatology,; Harvard Medical School, Boston, MA 02114, USA.
- Ultraviolet-B radiation (UVR) of mouse skin promotes both local and systemic immune aberrations that are thought to be important in the pathogenesis of cutaneous malignancies. Acute, low-dose UVR regimens inhibit the induction of contact hypersensitivity (CH) in genetically susceptible mice by TNF-alpha-dependent mech
- Knowledge and practices about HIV transmission among barbers of Nagpur City.
- Indian J Med Sci. 1999 Apr;53(4):167-71. Unique Identifier : AIDSLINE MED/20159552
- Khandait DW; Ambadekar NN; Vasudeo ND; Dept. of Preventive and Social Medicine, Govt. Medical College,; Nagpur.
- Of 60 cases of culture bound syndromes seen in psychiatry OPD. Dhat syndrome was most common (76.7%), followed by possession syndrome (13.3%). Depression by the most common associated psychiatric disorder. As the data on culture bound syndromes in Indian subcontinent is less, this study calls for careful evaluation of
- Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin.
- Infect Immun. 2000 Mar;68(3):1014-8. Unique Identifier : AIDSLINE MED/20143700
- Lauw FN; ten Hove T; Dekkers PE; de Jonge E; van Deventer SJ; van Der Poll T; Laboratory of Experimental Internal Medicine, University of; Amsterdam, Amsterdam, The Netherlands. F.N.Lauw@AMC.UVA.NL
- Endotoxin (lipopolysaccharide [LPS]) tolerance is characterized by a reduced capacity of monocytes to produce proinflammatory cytokines upon restimulation in vitro. To determine whether LPS exposure induces a change in lymphocyte cytokine production and whether this results in a shift in the T-helper 1 (Th1)/Th2 balan
- Decreased production of local immunoglobulin A to Pneumocystis carinii in bronchoalveolar lavage fluid from human immunodeficiency virus-positive patients.
- Infect Immun. 2000 Mar;68(3):1054-60. Unique Identifier : AIDSLINE MED/20143706
- Jalil A; Moja P; Lambert C; Perol M; Cotte L; Livrozet JM; Boibieux A; Vergnon JM; Lucht F; Tran R; Contini C; Genin C; Groupe Immunite des Muqueuses et Agents Pathogenes, University; of Saint-Etienne, Saint-Etienne, Hopital de Lyon, Lyon, France.
- An enzyme-linked immunosorbent assay and a Western blot analysis were developed to study the antibody response to Pneumocystis carinii in serum and bronchoalveolar lavage fluid from 27 human immunodeficiency virus 27 (HIV)-infected patients with P. carinii pneumonia (Pcp), 32 patients without Pcp, and 51 HIV-negative
- Tumor necrosis factor receptor p55-deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance.
- Infect Immun. 2000 Mar;68(3):1243-51. Unique Identifier : AIDSLINE MED/20143732
- Zhao YX; Lajoie G; Zhang H; Chiu B; Payne U; Inman RD; Division of Rheumatology, Toronto Western Hospital, University of; Toronto, Toronto, Canada.
- Tumor necrosis factor (TNF) has generally been regarded as a protective cytokine in host defense against bacterial infections. In the present study, we evaluated the role of TNF in the acute phase of infection by Yersinia enterocolitica by using mice rendered genetically deficient in TNF receptor p55 (TNFRp55(-/-)). U
- The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis.
- Infect Immun. 2000 Mar;68(3):1312-8. Unique Identifier : AIDSLINE MED/20143742
- Reichmann G; Walker W; Villegas EN; Craig L; Cai G; Alexander J; Hunter CA; Department of Pathobiology, University of Pennsylvania,; Philadelphia, Pennsylvania 19104-6050, USA.
- Since the CD40/CD40 ligand (CD40L) interaction is involved in the regulation of macrophage production of interleukin 12 (IL-12) and T-cell production of gamma interferon (IFN-gamma), effector cell functions associated with resistance to Toxoplasma gondii, the role of CD40L in immunity to this parasite was assessed. In
- A regulatory role for interleukin 4 in differential inflammatory responses in the lung following infection of mice primed with Th1- or Th2-inducing pertussis vaccines.
- Infect Immun. 2000 Mar;68(3):1383-90. Unique Identifier : AIDSLINE MED/20143750
- McGuirk P; Mills KH; Infection and Immunity Group, Department of Biology, National; University of Ireland, Maynooth, County Kildare, Ireland.
- Protection against infectious pathogens at mucosal surfaces is dependent on local antibody responses, production of inflammatory mediators, and recruitment of immune effector cells to the site of infection. Since Th1 and Th2 cells produce cytokines with pro- and anti-inflammatory activities, immunization with vaccines
- Listeria monocytogenes as a short-lived delivery system for the induction of type 1 cell-mediated immunity against the p36/LACK antigen of Leishmania major.
- Infect Immun. 2000 Mar;68(3):1498-506. Unique Identifier : AIDSLINE MED/20143765
- Soussi N; Milon G; Colle JH; Mougneau E; Glaichenhaus N; Goossens PL; Unite d'Immunophysiologie et Parasitisme Intracellulaire,; Institut Pasteur, 75724 Paris Cedex 15, France.
- Listeria monocytogenes has been used as an experimental live vector for the induction of CD8-mediated immune responses in various viral and tumoral experimental models. Susceptibility of BALB/c mice to Leishmania major infection has been correlated to the preferential development of Th2 CD4 T cells through an early pr
- Complement activation in Mycoplasma fermentans-induced mycoplasma clearance from infected cells: probing of the organism with monoclonal antibodies against M161Ag.
- Infect Immun. 2000 Mar;68(3):1672-80. Unique Identifier : AIDSLINE MED/20143786
- Kikkawa S; Matsumoto M; Sasaki T; Nishiguchi M; Tanaka K; Toyoshima K; Seya T; Department of Immunology, Osaka Medical Center for Cancer and; Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan.
- Mycoplasma fermentans, a cell wall-less prokaryote, is capable of infecting humans and has been suggested to serve as a cofactor in AIDS development. Recently, we discovered a novel lipoprotein with a molecular mass of 43 kDa originating from M. fermentans. This protein, named M161Ag, activated human complement via th
- Polymorphonuclear neutrophils are necessary for the recruitment of CD8(+) T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection.
- Infect Immun. 2000 Mar;68(3):1746-51. Unique Identifier : AIDSLINE MED/20143801
- de Oca RM; Buendia AJ; Del Rio L; Sanchez J; Salinas J; Navarro JA; Departamento de Histologia y Anatomia Patologica, Facultad de; Veterinaria, Universidad de Murcia, Murcia, Spain.
- The role of polymorphonuclear neutrophils (PMNs) in the development of the specific immune response against Chlamydophila abortus (Chlamydia psittaci serotype 1) infection was studied in a pregnant mouse model involving treatment with RB6-8C5 monoclonal antibody. PMN depletion significantly affected the immune respons
- Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive.
- Invest Ophthalmol Vis Sci. 2000 Mar;41(3):805-10. Unique Identifier : AIDSLINE MED/20174839
- Hazlett LD; McClellan S; Kwon B; Barrett R; Department of Anatomy/Cell Biology, Wayne State University School; of Medicine, Detroit, Michigan 48201, USA. lhazlett@med.wayne.edu
- PURPOSE: Mice favoring Th1 (C57BL/6, C57BL/10, and B10.D2/nSn) versus Th2 (BALB/c, BALB/cBy, BALB.B, and BALB.K) response development were evaluated for their response to infection with Pseudomonas aeruginosa. This study addresses the question of whether Th1 versus Th2 response propensity affects the pathogenesis of b
- Th1 versus Th2 immune responses in autoimmune lacrimal gland disease in MRL/Mp mice.
- Invest Ophthalmol Vis Sci. 2000 Mar;41(3):826-31. Unique Identifier : AIDSLINE MED/20174842
- Jabs DA; Lee B; Whittum-Hudson JA; Prendergast RA; Department of Ophthalmology, The Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205, USA. dajabs@jhmi.edu
- PURPOSE: In MRL/Mp-lpr/lpr (MRL/lpr) and MRL/Mp-+/+ (MRL/+) mice, a T-cell-driven lacrimal gland inflammation spontaneously develops that is a model for Sjogren s syndrome. The lacrimal gland lesions in these mice were evaluated by immunohistochemistry for the relative contributions of T-helper (Th)1 versus Th2 immune
- HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells.
- J Biol Chem. 2000 Feb 11;275(6):4159-65. Unique Identifier : AIDSLINE MED/20127897
- Zauli G; Secchiero P; Rodella L; Gibellini D; Mirandola P; Mazzoni M; Milani D; Dowd DR; Capitani S; Vitale M; Department of Morphology and Embryology, Anatomy Section,; University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara,; Italy. zlg@dns.unife.it
- Treatment of dopaminergic rat PC12 cells with human immunodeficiency virus, type 1 (HIV-1) Tat protein or tat cDNA inhibited the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for the dopamine biosynthetic pathway, as well as the production and release of dopamine into the culture medium. Moreover,
- HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution.
- J Biol Chem. 2000 Feb 11;275(6):4171-6. Unique Identifier : AIDSLINE MED/20127899
- Collette Y; Arold S; Picard C; Janvier K; Benichou S; Benarous R; Olive D; Dumas C; U119 INSERM, Universite de la Mediterranee, 13009 Marseille,; France. collette@marseille.inserm.fr
- The nef gene is required for optimal viral spread of human and simian immunodeficiency viruses. However, the molecular mechanisms underlying the action of the Nef proteins may not be identical for all viral families. Here we investigate the interaction between the Nef protein of human and simian immunodeficiency virus
- Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.
- J Biol Chem. 2000 Feb 11;275(6):4383-90. Unique Identifier : AIDSLINE MED/20127929
- Tetsuka T; Uranishi H; Imai H; Ono T; Sonta S; Takahashi N; Asamitsu K; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi; 467-8601, Japan.
- The amino-terminal enhancer of split (AES) encodes a 197-amino acid protein that is homologous to the NH(2)-terminal domain of the Drosophila Groucho protein but lacks COOH-terminal WD40 repeats. Although the Drosophila Groucho protein and its mammalian homologs, transducin-like enhancer of split proteins, are known t
- Green fluorescence protein as a transcriptional reporter for the long terminal repeats of the human immunodeficiency virus type 1.
- J Virol Methods. 2000 Feb;84(2):127-38. Unique Identifier : AIDSLINE MED/20143197
- Kar-Roy A; Dong W; Michael N; Li Y; Department of Microbiology and Immunology, University of Maryland; School of Medicine, Baltimore 21201, USA.
- Using the enhanced green fluorescence protein (EGFP), a transient reporter expression system was established to assess the transcriptional activity of the long terminal repeats (LTR) of primary isolates of the human immunodeficiency virus type 1 (HIV-1). Consistent with the conventional chloramphenicol acetyl transfer
- Species identification of Mycobacterium avium complex isolates by a variety of molecular techniques.
- J Clin Microbiol. 2000 Feb;38(2):508-12. Unique Identifier : AIDSLINE MED/20122413
- Beggs ML; Stevanova R; Eisenach KD; Departments of Pathology, University of Arkansas for Medical; Sciences, Little Rock, AR, USA. BeggsMarjorieL@exchange.uams.edu
- Organisms in the Mycobacterium avium complex (MAC; M. avium, M. intracellulare, and nonspecific or X MAC) are emerging pathogens among individual organisms of which significant genetic variability is displayed. The objective of the present study was to evaluate various molecular methods for the rapid and definitive
- Value of different assays for detection of human cytomegalovirus (HCMV) in predicting the development of HCMV disease in human immunodeficiency virus-infected patients.
- J Clin Microbiol. 2000 Feb;38(2):563-9. Unique Identifier : AIDSLINE MED/20122423
- Blank BS; Meenhorst PL; Mulder JW; Weverling GJ; Putter H; Pauw W; van Dijk WC; Smits P; Lie-A-Ling S; Reiss P; Lange JM; National AIDS Therapy Evaluation Center, Department of Internal; Medicine, Academic Medical Center, University of Amsterdam, The; Netherlands. S.N.Blank@amc.uva.nl
- In the present prospective study, five blood tests for detection of human cytomegalovirus (HCMV), nucleic acid sequence-based amplification (NASBA) for detection of early (immediate-early antigen) and late (pp67) mRNA, PCR for detection of HCMV DNA (DNA PCR), culture, and pp65 anti
- Screening for hepatitis C virus in human immunodeficiency virus-infected individuals.
- J Clin Microbiol. 2000 Feb;38(2):575-7. Unique Identifier : AIDSLINE MED/20122425
- Thio CL; Nolt KR; Astemborski J; Vlahov D; Nelson KE; Thomas DL; Division of Infectious Diseases, The Johns Hopkins School of; Medicine, Baltimore, Maryland 21205, USA.
- Immunosuppression from human immunodeficiency virus (HIV) may impair antibody formation, and false-negative hepatitis C virus antibody (anti-HCV) tests have been reported in individuals coinfected with HIV and HCV. It is unknown if the frequency of false-negative tests is sufficiently high to change screening recommen
- PCR-Based assay to quantify human immunodeficiency virus type 1 DNA in peripheral blood mononuclear cells.
- J Clin Microbiol. 2000 Feb;38(2):630-4. Unique Identifier : AIDSLINE MED/20122435
- Christopherson C; Kidane Y; Conway B; Krowka J; Sheppard H; Kwok S; Roche Molecular Systems, Inc., Alameda, California 94501, USA.; Cindy.Christopherson@Roche.com
- An assay that quantifies the amount of human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells has been developed. PCR amplification of the HIV-1 DNA is performed in the presence of an internal quantitation standard, and colorimetric detection of the amplified product is performed with mi
- Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies.
- J Clin Microbiol. 2000 Feb;38(2):696-701. Unique Identifier : AIDSLINE MED/20122446
- Martin JN; Amad Z; Cossen C; Lam PK; Kedes DH; Page-Shafer KA; Osmond DH; Forghani B; Department of Epidemiology and Biostatistics, University of; California, San Francisco, San Francisco, California 94105, USA.; martin@psg.ucsf.edu
- Agreement between assays for the detection of human herpesvirus 8 (HHV-8) antibodies has been limited. In part, this disagreement has been because assay calibration (i.e., differentiating positive from negative results) has not been done in a standardized fashion with reference to a wide spectrum of HHV-8-infected (tr
- Performance of a multiplex qualitative PCR LCx assay for detection of human immunodeficiency virus type 1 (HIV-1) group M subtypes, group O, and HIV-2.
- J Clin Microbiol. 2000 Feb;38(2):716-23. Unique Identifier : AIDSLINE MED/20122450
- Abravaya K; Esping C; Hoenle R; Gorzowski J; Perry R; Kroeger P; Robinson J; Flanders R; Abbott Laboratories, Abbott Park, Illinois 60064, USA.; klara.abravaya@add.ssw.abbott.com
- Early detection of human immunodeficiency virus (HIV) in blood and blood products can be achieved by a sensitive nucleic acid amplification-based assay. We report on the performance of a PCR-based qualitative assay that detects both HIV type 1 (HIV-1) and HIV-2 with a sensitivity of 20 to 50 copies/ml. The assay has a
- Comparison of three assays for cytomegalovirus detection in AIDS patients at risk for retinitis.
- J Clin Microbiol. 2000 Feb;38(2):727-32. Unique Identifier : AIDSLINE MED/20122452
- Wattanamano P; Clayton JL; Kopicko JJ; Kissinger P; Elliot S; Jarrott C; Rangan S; Beilke MA; Section of Infectious Diseases, Tulane University School of; Medicine, and Tulane University School of Public Health and; Tropical Medicine, New Orleans, Louisiana 70112, USA.
- The purpose of this study was to determine the sensitivity and specificity of three different methods of cytomegalovirus ( CMV ) detection for AIDS patients at risk for CMV retinitis. Patients with CD4(+) counts of
- Resistance of Trichomonas vaginalis to metronidazole: report of the first three cases from Finland and optimization of in vitro susceptibility testing under various oxygen concentrations.
- J Clin Microbiol. 2000 Feb;38(2):763-7. Unique Identifier : AIDSLINE MED/20122459
- Meri T; Jokiranta TS; Suhonen L; Meri S; Department of Bacteriology and Immunology, Haartman Institute and; HD Laboratories, University and University Central Hospital of; Helsinki, Finland. Taru.Meri@helsinki.fi
- Trichomonas vaginalis is a globally common sexually transmitted human parasite. Many strains of T. vaginalis from around the world have been described to be resistant to the current drug of choice, metronidazole. However, only a few cases of metronidazole resistance have been reported from Europe. The resistant strain
- Analysis of genetic variability within the immunodominant epitopes of envelope gp41 from human immunodeficiency virus type 1 (HIV-1) group M and its impact on HIV-1 antibody detection.
- J Clin Microbiol. 2000 Feb;38(2):773-80. Unique Identifier : AIDSLINE MED/20122461
- Dorn J; Masciotra S; Yang C; Downing R; Biryahwaho B; Mastro TD; Nkengasong J; Pieniazek D; Rayfield MA; Hu DJ; Lal RB; HIV Immunology and Diagnostics Branch, National Center for HIV,; STD and TB Prevention, Centers for Disease Control and Prevntion,; Atlanta, Georgia 30333, USA.
- The serodiagnosis of human immunodeficiency virus type 1 (HIV-1) infection primarily relies on the detection of antibodies, most of which are directed against the immunodominant regions (IDR) of HIV-1 structural proteins. Among these, the N-terminal region of gp41 contains cluster I (amino acids [aa] 580 to 623), comp
- Comparison of blood collected in acid-citrate-dextrose and EDTA for use in human immunodeficiency virus peripheral blood mononuclear cell cultures.
- J Clin Microbiol. 2000 Feb;38(2):858-60. Unique Identifier : AIDSLINE MED/20122475
- Fiscus SA; Chakraborty H; Shepard R; Goodman M; Department of Microbiology & Immunology, University of North; Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7140,; USA. fiscussa@med.unc.edu
- Paired blood samples collected in acid-citrate-dextrose and EDTA were compared for human immunodeficiency virus (HIV) infectivity on the day of collection or after 1 day of storage at room temperature. No significant differences between the anticoagulants were observed. Culture positivity was significantly associated
- Hepatitis C virus quantitation: optimization of strategies for detecting low-level viremia.
- J Clin Microbiol. 2000 Feb;38(2):888-91. Unique Identifier : AIDSLINE MED/20122486
- Hofgartner WT; Kant JA; Weck KE; Department of Pathology, University of Pittsburgh, Pittsburgh,; Pennsylvania 15213-2500, USA.
- A long-term assessment of quantitative hepatitis C virus (HCV) testing was performed at the University of Pittsburgh Medical Center. The Quantiplex HCV RNA 2.0 branched-chain DNA (bDNA) assay (Bayer Diagnostics) for hepatitis C viral load determination was used to test 3,471 specimens. bDNA-negative samples were also
- Growth competition between Candida dubliniensis and Candida albicans under broth and biofilm growing conditions.
- J Clin Microbiol. 2000 Feb;38(2):902-4. Unique Identifier : AIDSLINE MED/20122490
- Kirkpatrick WR; Lopez-Ribot JL; McAtee RK; Patterson TF; Departments of Medicine, The University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78284, USA.; KIRKPATRICK@UTHSCSA.EDU
- Seven isolates each of Candida albicans and Candida dubliniensis were paired (11 pairs) and examined for competitive interaction. Equal numbers of CFU of each competitor were inoculated into Sabouraud dextrose broth and incubated at 37 degrees C with vigorous shaking under conditions favorable to either broth or biofi
- Comparative evaluation of two branched-DNA human immunodeficiency virus type 1 RNA quantification assays with lower detection limits of 50 and 500 copies per milliliter.
- J Clin Microbiol. 2000 Feb;38(2):914-7. Unique Identifier : AIDSLINE MED/20122493
- Manegold C; Krempe C; Jablonowski H; Kajala L; Dietrich M; Adams O; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Germany.; manegold@bni.uni-hamburg.de
- We have comparatively evaluated Quantiplex version 3.0 and version 2. 0 on 133 plasma samples and a repetitive dilution series. Version 3. 0 yielded higher human immunodeficiency virus RNA values, and the ratio of version 3.0 results to version 2.0 results decreased from 3. 47 below 1,000 copies/ml to 1.97 above 50,00
- 1,25-dihydroxyvitamin D3 treatment decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis.
- J Neuroimmunol. 2000 Mar 1;103(2):171-9. Unique Identifier : AIDSLINE MED/20159985
- Nashold FE; Miller DJ; Hayes CE; Department of Biochemistry, University of Wisconsin-Madison,; 53706, USA.
- Sunlight, which is required for vitamin D biosynthesis, may be protective in multiple sclerosis (MS), due to the immunoregulatory functions of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the hormonally active vitamin D metabolite. This hypothesis provided the impetus for the experiments reported here investigating mechan
- Prevention works for women: women's health at the CDC.
- J Am Med Womens Assoc. 2000 Winter;55(1):41-2, 46. Unique Identifier : AIDSLINE MED/20144661
- Coffin N; Green Y; Division of Media Relations, Centers for Disease Control and; Prevention, Atlanta, USA.
- Actively protecting America s health and safety, the Centers for Disease Control and Prevention (CDC) focuses on four priorities: 1) strengthening science for public health action, 2) collaborating with health care partners for prevention, 3) promoting healthy living at every stage of life, and 4) promoting health glo
- Transient expression of bacterial gene fragments in eukaryotic cells: implications for CD8(+) T cell epitope analysis.
- J Immunol Methods. 2000 Feb 3;234(1-2):137-47. Unique Identifier : AIDSLINE MED/20135947
- Wilson RL; White DW; Harty JT; Department of Microbiology, University of Iowa, 3-512 Bowen; Science Building, Iowa City, IA 52242, USA.
- CD8(+) T cells are potent effectors of acquired immunity against some viruses and intracellular bacterial pathogens. Antigens recognized by CD8(+) T cells are small, 8-9 amino acid peptides derived from proteins produced by the pathogen. These peptides are presented by MHC class I molecules on the surface of the infec
- Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses.
- J Invest Dermatol. 2000 Feb;114(2):295-302. Unique Identifier : AIDSLINE MED/20117883
- Cavani A; Nasorri F; Prezzi C; Sebastiani S; Albanesi C; Girolomoni G; Laboratory of Immunology, Istituto Dermopatico dell'Immacolata,; IRCCS, Rome, Italy. cavani@idi.it
- The contribution of T helper (Th) and T cytotoxic (Tc) type 1 lymphocytes in the expression of allergic contact dermatitis to haptens has been amply documented. Conversely, the existence of T cell-based regulatory mechanisms has been poorly investigated. Here, we examined the properties of a subset of nickel-specific
- Relationship between Sjogren's syndrome and human T-lymphotropic virus type I infection: follow-up study of 83 patients.
- J Lab Clin Med. 2000 Feb;135(2):139-44. Unique Identifier : AIDSLINE MED/20158205
- Nakamura H; Kawakami A; Tominaga M; Hida A; Yamasaki S; Migita K; Kawabe Y; Nakamura T; Eguchi K; The First Department of Internal Medicine, Nagasaki University; School of Medicine, Nagasaki City, Japan.
- We have previously demonstrated a high prevalence of Sjogren s syndrome (SS) in patients with human T-lymphotropic virus type I-associated myelopathy (HAM) in Nagasaki prefecture. The present follow-up study compared the clinical and laboratory findings of SS with or without human T-lymphotropic virus type I (HTLV-I)
- Periodic solutions: a robust numerical method for an S-I-R model of epidemics.
- J Math Biol. 1999 Dec;39(6):471-92. Unique Identifier : AIDSLINE MED/20136462
- Milner FA; Pugliese A; Department of Mathematics, Purdue University, West Lafayette, IN; 47907, USA. milner@math.purdue.edu
- We describe and analyze a numerical method for an S-I-R type epidemic model. We prove that it is unconditionally convergent and that solutions it produces share many qualitative and quantitative properties of the solution of the differential problem being approximated. Finally, we establish explicit sufficient conditi
- Taenia crassiceps cysticercosis: protective effect and immune response elicited by DNA immunization.
- J Parasitol. 2000 Feb;86(1):67-74. Unique Identifier : AIDSLINE MED/20163501
- Cruz-Revilla C; Rosas G; Fragoso G; Lopez-Casillas F; Toledo A; Larralde C; Sciutto E; Instituto de Investigaciones Biomedicas, Universidad Nacional; Autonoma de Mexico, Mexico, DF.
- The nucleotide sequence of a protective recombinant antigen of Taenia crassiceps cysticerci present in all stages of Taenia solium (KETc7), cloned into pcDNA3 plasmid with the signal peptide sequence of the beta-glycan receptor (pTc-sp7), has been shown to be effective in protecting mice against experimental infection
- Comparison of gingival and peripheral blood T cells among patients with periodontitis suggests skewing of the gingival T cell antigen receptor V beta repertoire.
- J Periodontal Res. 1999 Nov;34(8):445-56. Unique Identifier : AIDSLINE MED/20162909
- Karimzadeh K; Morrison J; Zadeh HH; Department of Periodontology, University of Southern; California-School of Dentistry, Los Angeles 90089, USA.
- The present study investigated the expression of different variable regions of T cell receptor beta-chain (V beta) among functional subsets of T cells, i.e. CD45RO+ (activated/memory), CD4+ and CD8+ in gingiva and peripheral blood of patients with periodontitis. Gingival tissue specimens (n = 25) and peripheral blood
- Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.
- J Med Chem. 2000 Feb 10;43(3):401-8. Unique Identifier : AIDSLINE MED/20135958
- Perola E; Xu K; Kollmeyer TM; Kaufmann SH; Prendergast FG; Pang YP; Mayo Clinic Cancer Center, Tumor Biology Program, Department of; Molecular Pharmacology, Molecular Neuroscience Program, Mayo; Medical School and Mayo Clinic, 200 First Street SW, Rochester,; Minnesota 55905, USA.
- Virtual screening of chemical databases is an emerging approach in drug discovery that uses computers to dock chemicals into the active site of a drug target to identify leads through evaluation of binding affinities of the chemicals. However, there are concerns about the validity and scope of the reported virtual scr
- Cryptosporidiosis: the treatment dilemma [editorial]
- J Med Microbiol. 2000 Mar;49(3):207-8. Unique Identifier : AIDSLINE MED/20170212
- Sterling CR
- A clinical, microbiological and economic analysis of a national service for the rapid molecular diagnosis of tuberculosis and rifampicin resistance in Mycobacterium tuberculosis.
- J Med Microbiol. 2000 Mar;49(3):271-8. Unique Identifier : AIDSLINE MED/20170220
- Drobniewski FA; Watterson SA; Wilson SM; Harris GS; Public Health Laboratory Service Mycobacterium Reference Unit,; Department of Microbiology, Guy's King's and St Thomas School of; Medicine, London.
- A clinical, microbiological and economic study of a national rapid molecular service for the identification of Mycobacterium tuberculosis and the determination of rifampicin resistance in smear-positive sputum samples (and other primary specimens) was performed. Ninety-one primary specimens, of which 55 were smear-pos
- Viral infections in free-living populations of the European wildcat.
- J Wildl Dis. 1999 Oct;35(4):678-86. Unique Identifier : AIDSLINE MED/20039683
- Leutenegger CM; Hofmann-Lehmann R; Riols C; Liberek M; Worel G; Lups P; Fehr D; Hartmann M; Weilenmann P; Lutz H; Department of Internal Veterinary Medicine, University of Zurich,; Switzerland. cmleutenegger@ucdavis.edu
- While the importance of viral infections is well studied in domestic cats, only limited information is available on their occurence and prevalence in the European wildcat (Felis silvestris silvestris). The aim of this study was to determine the prevalence of antibodies to feline coronavirus (FCoV), calicivirus (FCV),
- HIV risk from oral sex higher than many realize [news]
- JAMA. 2000 Mar 8;283(10):1279. Unique Identifier : AIDSLINE MED/20177197
- Stephenson J
- HIV's origins traced to 1930s [news]
- JAMA. 2000 Mar 8;283(10):1279. Unique Identifier : AIDSLINE MED/20177198
- Stephenson J
- A program to provide antiretroviral prophylaxis to health care personnel working overseas [letter]
- JAMA. 2000 Mar 8;283(10):1292-3. Unique Identifier : AIDSLINE MED/20177208
- Russi M; Hajdun M; Barry M
- Methadone maintenance vs 180-day psychosocially enriched detoxification for treatment of opioid dependence: a randomized controlled trial [see comments]
- Unique Identifier : AIDSLINE MED/20177211
- Sees KL; Delucchi KL; Masson C; Rosen A; Clark HW; Robillard H; Banys P; Hall SM; Department of Psychiatry, University of California, San Francisco; 94143-0984, USA.
- CONTEXT: Despite evidence that methadone maintenance treatment (MMT) is effective for opioid dependence, it remains a controversial therapy because of its indefinite provision of a dependence-producing medication. OBJECTIVE: To compare outcomes of patients with opioid dependence treated with MMT vs an alternative trea
- Strategies for long-term success in the treatment of HIV infection [clinical conference]
- JAMA. 2000 Mar 8;283(10):1329-34. Unique Identifier : AIDSLINE MED/20177216
- Gallant JE; Division of Infectious Diseases, The Johns Hopkins University; School of Medicine, Baltimore, MD 21287, USA.
- Highly active antiretroviral therapy has revolutionized the treatment of human immunodeficiency virus (HIV) infection, which can now be viewed as a chronic and manageable disease. However, HIV infection differs from other chronic diseases in that early treatment decisions can irrevocably alter the patient s response t
- [Human T lymphotropic virus type I]
- Unique Identifier : AIDSLINE MED/20101777
- Yamaguchi K; Blood Transfusion Service, Kumamoto University School of; Medicine.
- [Human immunodeficiency virus type 1, type 2]
- Nippon Rinsho. 1999 Nov;57 Suppl:372-8. Unique Identifier : AIDSLINE MED/20101778
- Handa N; Department of Clinical Laboratory, Tokyo Metropolitan Komagome; Hospital.
- Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine.
- Lab Invest. 2000 Feb;80(2):187-97. Unique Identifier : AIDSLINE MED/20163623
- Lewis W; Grupp IL; Grupp G; Hoit B; Morris R; Samarel AM; Bruggeman L; Klotman P; Department of Pathology, University of Cincinnati College of; Medicine, Ohio, USA. wlewis@emory.edu
- Cardiomyopathy in AIDS is an increasingly important clinical problem. Mechanisms of AIDS cardiomyopathy were explored using AIDS transgenic mice that express replication-incompetent HIV-1 (NL4-3delta gag/pol). Transgenic and FVB/n mice (n = 3 to 6 per cohort) received water ad libitum with and without zidovudine (3 -a
- Evolutionary stable strategy: a test for theories of retroviral pathology which are based upon the concept of molecular mimicry.
- J Theor Biol. 2000 Feb 7;202(3):213-29. Unique Identifier : AIDSLINE MED/20127960
- Powell PD; DeMartini JC; Azari P; Stargell LA; Cordain L; Tucker A; Department of Pathology, Colorado State University, Ft. Collins,; CO, USA.
- The genetic makeup of animal and plant populations is determined by established principles and concepts. Ecology and evolution provide a basic theoretical framework for understanding how genetic changes occur in populations. Whether these rules can be applied to host retroviral populations is unknown. Individuals infe
- [HIV infection: to eradicate it or control it? (editorial)]
- Med Clin (Barc). 1999 Dec 4;113(19):741-2. Unique Identifier : AIDSLINE MED/20144378
- Gatell JM
- Tolerability and side-effects of post-exposure prophylaxis for HIV infection [letter]
- Lancet. 2000 Feb 26;355(9205):722-3. Unique Identifier : AIDSLINE MED/20166547
- Parkin JM; Murphy M; Anderson J; El-Gadi S; Forster G; Pinching AJ
- A study of HIV post-exposure prophylaxis in 28 recipients showed that indinavir-containing regimens were poorly tolerated. This finding has implications for compliance and efficacy of the currently recommended combinations.
- Gene therapy HIV scare proves to be a false alarm [news]
- Lancet. 2000 Feb 26;355(9205):733. Unique Identifier : AIDSLINE MED/20166554
- McCarthy M
- Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice.
- Lipids. 2000 Jan;35(1):61-9. Unique Identifier : AIDSLINE MED/20158472
- Tomobe YI; Morizawa K; Tsuchida M; Hibino H; Nakano Y; Tanaka Y; Tsukuba Research Laboratory, NOF Corporation, Ibaraki, Japan.
- This study was designed to examine the immunomodulatory effects of dietary docosahexaenoic acid (DHA) in the absence of eicosapentaenoic acid (EPA). We investigated the effects of feeding dietary DHA ethyl ester (DHA-Et) (97% pure) at levels of 4.8 wt% of the total diet and of feeding EPA ethyl ester (EPA-Et) (99% pur
- Predictive value of the acid fast smear for detection of Mycobacterium tuberculosis in respiratory specimens in a reference center of HIV/AIDS in Rio de Janeiro, Brazil.
- Unique Identifier : AIDSLINE MED/20138384
- Conde MB; Figueira CM; Moraes R; Fonseca LS
- Elevated blood lead levels among internationally adopted children--United States, 1998.
- MMWR Morb Mortal Wkly Rep. 2000 Feb 11;49(5):97-100. Unique Identifier : AIDSLINE MED/20181022
- Lead poisoning has been reported recently among Chinese children adopted by U.S. citizens. However, little is known about the prevalence of elevated blood lead levels (BLLs) among adoptees from China and other countries. Persistent sources of lead exposure outside the
- Differential regulation of germinal center genes, BCL6 and SWAP-70, during the course of MAIDS.
- Mol Immunol. 1999 Oct-Nov;36(15-16):1043-53. Unique Identifier : AIDSLINE MED/20162133
- Qi CF; Jessberger R; Torrey TA; Taddesse-Heath L; Ohta Y; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-0760, USA. cqi@atlas.niaid.nih.gov
- Germinal centers (GC) are the sites of antigen-driven B cell switch recombination, V(D)J gene hypermutation, and selection to generate high-afinity CD38+ memory B cells. A marked expansion of GC associated with hypergammaglobulinemia followed by complete disruption of normal splenic architecture and a striking drop in
- Immunostimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83.
- Mol Immunol. 1999 Dec;36(17):1131-9. Unique Identifier : AIDSLINE MED/20162141
- Rico AI; Angel SO; Alonso C; Requena JM; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad; Autonoma de Madrid, Spain.
- Emerging evidence indicates that the heat shock proteins (HSPs), a set of highly evolutionary conserved proteins, are playing essential roles in both normal processes of the immune system and specific immune responses. In a previous work, we demonstrated that the Leishmania infantum HSP70 possesses remarkable immunost
- Kaposi's sarcoma herpesvirus-associated Castleman's disease with POEMS syndrome.
- Muscle Nerve. 2000 Mar;23(3):436-9. Unique Identifier : AIDSLINE MED/20146041
- Kim DE; Kim HJ; Kim YA; Lee KW; Department of Neurology, College of Medicine, Seoul National; University Hospital, 28 Yongon-dong, Chongno-ku, Seoul 110-744,; Korea.
- The pathogenic link between POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes, and various other clinical signs) syndrome and Castleman s disease is unclear. Roles for M protein in POEMS syndrome and cytokines in systemic manifestations of multicentric Castleman s disease have been suggested
- Images in clinical medicine. Hepatic hemangioma.
- N Engl J Med. 2000 Mar 16;342(11):791. Unique Identifier : AIDSLINE MED/20166596
- Landor M; Petrozzo P; Catholic Medical Center of Brooklyn and Queens, Elmhurst, NY; 11373, USA.
- Carcinoma of the anal canal.
- N Engl J Med. 2000 Mar 16;342(11):792-800. Unique Identifier : AIDSLINE MED/20166597
- Ryan DP; Compton CC; Mayer RJ; Department of Adult Oncology, Dana-Farber Cancer Institute,; Massachusetts General Hospital, Boston 02115, USA.
- Despite the rarity of carcinoma of the anal canal, remarkable progress has been achieved during the past 30 years in understanding its pathogenesis and improving treatment. Largely because of the rigorous collection of data and the treatment of patients in clinical trials, it is now widely accepted that the majority o
- [Missed infections in immigrant children and the medical care for underage refugees (letter; comment)]
- Ned Tijdschr Geneeskd. 2000 Jan 8;144(2):97-8. Unique Identifier : AIDSLINE MED/20139068
- Jak LG
- Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.
- Oncogene. 2000 Feb 3;19(5):599-607. Unique Identifier : AIDSLINE MED/20162330
- Epinat JC; Kazandjian D; Harkness DD; Petros S; Dave J; White DW; Gilmore TD; Department of Biology, Boston University, Massachusetts; 02215-2406, USA.
- The retroviral oncoprotein v-Rel is a member of the Rel/ NF-kappaB family of transcription factors. v-Rel has multiple changes as compared to the proto-oncoprotein c-Rel, and these changes render v-Rel highly oncogenic in avian lymphoid cells. Previous results have shown that three mutant residues in the eleven helper
- Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein.
- Oncogene. 2000 Feb 10;19(6):827-30. Unique Identifier : AIDSLINE MED/20162327
- Kaida A; Ariumi Y; Ueda Y; Lin JY; Hijikata M; Ikawa S; Shimotohno K; Department of Viral Oncology, Institute for Virus Research, Kyoto; University, Japan.
- We have previously demonstrated that the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein represses the trans-activation function of p53 tumor suppressor protein. Recently, several proteins with sequence homology to p53 have been identified. In this study, we demonstrated that Tax represses the trans-activa
- The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2.
- Oncogene. 2000 Feb 17;19(7):850-7. Unique Identifier : AIDSLINE MED/20169585
- Kratzer F; Rosorius O; Heger P; Hirschmann N; Dobner T; Hauber J; Stauber RH; Institute for Clinical and Molecular Virology, University of; Erlangen-Nurnberg, Schlossgarten 4, D-91054 Erlangen, Germany.
- The E1B-55K and E4orf6 oncoproteins of adenovirus type 5 are involved in the export of viral mRNAs. Previously, it was suggested that a complex composed of E1B-55K and E4orf6 serves as a nucleocytoplasmic transporter for viral mRNAs in which the E4orf6 protein directs both nuclear import and export. We now demonstrate
- Efficacy of a vibratory stimulus for the relief of HIV-associated neuropathic pain.
- Pain. 2000 Feb;84(2-3):291-6. Unique Identifier : AIDSLINE MED/20133068
- Paice JA; Shott S; Oldenburg FP; Zeller J; Swanson B; Palliative Care, Division of Hematology/Oncology, Northwestern; Memorial Hospital, Chicago, IL, USA. jpaice@nmh.org
- Pain related to HIV disease is frequently debilitating. Of the many pain syndromes that occur in persons with HIV, distal symmetrical polyneuropathy (DSPN) is particularly devastating. Because DSPN often responds, at best, only partially to available pharmacologic interventions, non-pharmacologic interventions need to
- Epidemiology of HIV/AIDS in children.
- Pediatr Clin North Am. 2000 Feb;47(1):1-20, v. Unique Identifier : AIDSLINE MED/20162747
- Lindegren ML; Steinberg S; Byers RH Jr; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; Centers for Disease Control and Prevention, Atlanta, Georgia,; USA. mll3@cdc.gov
- HIV infection has been a major cause of morbidity and mortality since the first cases of AIDS among children were reported in 1982 in the United States . Considerable advances, especially in the past 5 years, in the understanding of the pathogenesis, diagnosis, treatment, monitoring, an
- Organ-specific manifestations of HIV disease in children.
- Pediatr Clin North Am. 2000 Feb;47(1):109-25. Unique Identifier : AIDSLINE MED/20162752
- Abuzaitoun OR; Hanson IC; Department of Pediatrics, Texas Children's Hospital, Baylor; College of Medicine, Houston, USA.
- The clinical manifestations of HIV disease in children affect multiple organ systems. The severity of each manifestation varies by organ system and can be related in many cases to multifactorial causes, namely HIV replication in affected tissue, concomitant opportunistic infection of the organ, effect of concurrent im
- Medical management of HIV disease in children.
- Pediatr Clin North Am. 2000 Feb;47(1):127-53. Unique Identifier : AIDSLINE MED/20162753
- Laufer M; Scott GB; Division of Pediatric Infectious Disease, University of Miami; School of Medicine, Florida, USA.
- Significant advances have been made in the understanding of the pathophysiology of HIV infection since the beginning of the epidemic. This knowledge has translated into the development of new therapies for HIV and opportunistic infections, laboratory advances in monitoring viral and immune status, and a better underst
- Antiretroviral therapy of HIV infection in children.
- Pediatr Clin North Am. 2000 Feb;47(1):155-69. Unique Identifier : AIDSLINE MED/20162754
- Palumbo PE; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark, USA.; palumbo@umdnj.edu
- Much progress has been made in the therapy of pediatric HIV infection, which has been transformed from a usually fatal disease into that of a chronic disease model. Early, aggressive therapy with the goal of complete suppression of viral replication (undetectable plasma virus) should be the therapeutic goal, but this
- HIV and AIDS in adolescents.
- Pediatr Clin North Am. 2000 Feb;47(1):171-88. Unique Identifier : AIDSLINE MED/20162755
- Futterman D; Chabon B; Hoffman ND; Adolescent AIDS Program, Montefiore Medical Center, Bronx, New; York, USA. futterma@aecom.yu.edu
- HIV infection in adolescents continues to challenge health care providers, policy makers, and advocates for youth. Primary care providers working with parents of adolescents and at-risk youth are in a unique position to identify or help develop HIV prevention and care programs that address many needs. Effective interv
- Caring for the child and family with HIV disease.
- Unique Identifier : AIDSLINE MED/20162756
- Boland MG; Francois-Xavier Bagnoud Center, University of Medicine and; Dentistry of New Jersey, Newark, USA. Bolandmg@umdnj.edu
- Caring for children with HIV infection is a much more optimistic process than in the beginning of the epidemic. Antiretroviral therapies are available, and additional drugs are receiving approval from the US Food and Drug Administration. Cautious optimism must be tempered with an understanding that living with the dis
- Management of HIV-infected children in the home and institutional settings. Care of children and infections control in schools, day care, hospital settings, home, foster care, and adoption.
- Pediatr Clin North Am. 2000 Feb;47(1):203-39. Unique Identifier : AIDSLINE MED/20162757
- Dominguez KL; Maternal Child Transmission, Pediatric and Adolescent Studies; Section, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA.
- The likelihood of high-risk pediatric exposure to HIV infection, other than perinatal exposure, has been shown to be low in most cases, and HIV PEP should be considered on a case-by-case basis. Generic considerations in the management of children who have become HIV infected emphasizes the principles of inclusion, mai
- Update on perinatal HIV transmission.
- Pediatr Clin North Am. 2000 Feb;47(1):21-38. Unique Identifier : AIDSLINE MED/20162748
- Fowler MG; Simonds RJ; Roongpisuthipong A; Pediatric and Adolescent Studies Section, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA. mgf1@cdc.gov
- Over the past decade, much progress has been made in understanding the risk factors and timing of perinatal HIV transmission. Even more impressive have been the successful clinical trials with antiretrovirals, such as ZDV, ZDV- 3TC , and
- Prevention of HIV infection in children.
- Pediatr Clin North Am. 2000 Feb;47(1):241-60. Unique Identifier : AIDSLINE MED/20162758
- Bulterys M; Fowler MG; Mother-Child Transmission, Pediatric and Adolescent Studies; Section, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA.
- The threshold of a new century is an opportune time to review advances in the prevention of HIV infection in children. In the United States , progress in the ability to virtually eliminate perinatal HIV transmission that was unthinkable just a few years ago has been achieved. Clinicians
- Diagnosis of HIV infection in children.
- Pediatr Clin North Am. 2000 Feb;47(1):39-63. Unique Identifier : AIDSLINE MED/20162749
- Nielsen K; Bryson YJ; Department of Pediatrics, University of California, Los Angeles,; School of Medicine, USA.
- Many advances have been made in the area of HIV diagnostics. Commercially available virologic assays are sensitive and specific for the early detection of HIV in perinatal infection. The timing of the transmission of HIV from mother to child (in utero, at the time of birth, or postnatally by breast-feeding) is a criti
- Viral and immunopathogenesis of vertical HIV-1 infection.
- Pediatr Clin North Am. 2000 Feb;47(1):65-78. Unique Identifier : AIDSLINE MED/20162750
- Luzuriaga K; Sullivan JL; Department of Pediatrics, University of Massachusetts Medical; School, Worcester, USA. katherine.luzuriaga@ummed.edu
- High-level viral replication is the primary determinant of CD4 depletion or disease development in HIV-1--infected children. The developing immune system of infants might allow for more efficient viral replication and less efficient immune containment of viral replication. Advances in the understanding of the pathogen
- Opportunistic infections and other clinical manifestations of HIV disease in children.
- Pediatr Clin North Am. 2000 Feb;47(1):79-108. Unique Identifier : AIDSLINE MED/20162751
- Abrams EJ; Department of Pediatrics, College of Physicians and Surgeons,; Columbia University, New York, USA. eja1@columbia.edu
- As the decade draws to a close, physicians can be cautiously optimistic about the prevention and treatment of opportunistic infections in children with HIV disease. As more children receive therapy with powerful antiretroviral regimens, fewer are likely to be at risk for opportunistic pathogens. The widespread use of
- Inhibition of in vitro and ex vivo translation by a transplatin-modified oligo(2'-O-methylribonucleotide) directed against the HIV-1 gag-pol frameshift signal.
- Nucleic Acids Res. 2000 Jan 15;28(2):438-45. Unique Identifier : AIDSLINE MED/20075132
- Aupeix-Scheidler K; Chabas S; Bidou L; Rousset JP; Leng M; Toulme JJ; INSERM U.386, IFR Pathologies Infectieuses, Universite Victor; Segalen Bordeaux 2, 146 Rue Leo Saignat, 33076 Bordeaux Cedex,; France,
- A 2 -O-methylribooligonucleotide containing a G1.U.G3 triad modified by trans-diamminedichloro-platinum(II) was targeted to the RNA region responsible for the gag-pol frameshifting during translation of the HIV-1 mRNA. The binding of the platinated oligonucleotide to its target RNA induced a rearrangement of the (G1,
- In vitro evidence for the interaction of tRNA(3)(Lys) with U3 during the first strand transfer of HIV-1 reverse transcription.
- Nucleic Acids Res. 2000 Jan 15;28(2):634-40. Unique Identifier : AIDSLINE MED/20075156
- Brule F; Bec G; Keith G; Le Grice SF; Roques BP; Ehresmann B; Ehresmann C; Marquet R; Unite Propre de Recherche No. 9002 du CNRS, Institut de Biologie; Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084; Strasbourg Cedex, France,
- Over the course of its evolution, HIV-1 has taken maximum advantage of its tRNA(3)(Lys)primer by utilizing it in several steps of reverse transcription. Here, we have identified a conserved nonanucleotide sequence in the U3 region of HIV-1 RNA that is complementary to the anticodon stem of tRNA(3)(Lys). In order to te
- Commentary on the possibility that Viagra may contribute to transmission of HIV and other sexual diseases among older adults.
- Psychol Rep. 1999 Dec;85(3 Pt 1):942-4. Unique Identifier : AIDSLINE MED/20136713
- Paniagua FA; Department of Psychiatry and Behavioral Sciences, University of; Texas Medical Branch, Galveston 77550-0425, USA.
- Many older male adults experiencing impotence are being treated with Viagra. Scientific and media reports indicate that this medication is effective in re-establishing sexual relationships among these men. Despite the benefits that Viagra may have in the treatment of impotence among older adults, increased sexual acti
- Alexithymic characteristics of HIV-positive patients.
- Psychol Rep. 1999 Dec;85(3 Pt 1):963-70. Unique Identifier : AIDSLINE MED/20136717
- Fukunishi I; Hirabayashi N; Matsumoto T; Yamanaka K; Fukutake K; Tokyo Metropolitan Organization for Medical Research, Tokyo; Institute of Psychiatry, Japan. fukunisi@prit.go.jp
- Despite extensive psychiatric research on HIV-positive patients, there are no published studies on alexithymia. Alexithymic characteristics and related factors were examined in a sample of 81 HIV-positive patients using the modified Beth Israel Psychosomatic Questionnaire and the Social Support of Stress and Coping In
- [Candida pneumopathy: fact or fiction? (editorial)]
- Rev Pneumol Clin. 1999 Dec;55(6):349-51. Unique Identifier : AIDSLINE MED/20149730
- Azoulay E; Mayaud C
- [Bacteremia and Pasteurella multocida pneumonia revealing HIV infection]
- Rev Pneumol Clin. 1999 Dec;55(6):403-6. Unique Identifier : AIDSLINE MED/20149737
- Bernier C; Bouvard E; Saidi F; Parrot A; Meyniel D; Service des Urgences Medicales, Hopital Tenon, Paris.
- Pasteurella multocida is a major pathogen in local wound infections due to animal bites. Pneumonia and bacteremia are less frequent and usually associated with local or general impairment of host defenses. Scarce reports exist about Pasteurella multocida infections in HIV infected patients. We report here a case of hy
- Possible role of the plasminogen receptor as a site of interaction of the human immunodeficiency virus p24 immunosuppressive heptapeptide Ch7 with the host immune system.
- Scand J Immunol. 2000 Feb;51(2):164-7. Unique Identifier : AIDSLINE MED/20182630
- Giacomini E; Chersi A; Giordani L; Luzzati AL; Department of Immunology, Istituto Superiore di Sanita, Rome,; Italy.
- Previous work from our laboratory demonstrated that a synthetic heptapeptide (Ch7: RGSDIAG), corresponding to a conserved sequence of human immunodeficiency virus (HIV) core protein p24 (amino acids 232- 238), was able to specifically abrogate antigen-induced responses in cultures of normal human peripheral blood mono
- Effects of subcutaneous interleukin-2 therapy on phenotype and function of peripheral blood mononuclear cells in human immunodeficiency virus infected patients.
- Scand J Immunol. 2000 Feb;51(2):168-75. Unique Identifier : AIDSLINE MED/20182631
- Aladdin H; Larsen CS; Moller BK; Ullum H; Buhl MR; Gerstoft J; Skinhoj P; Pedersen BK; Department of Infectious Diseases, Righospitalet, Copenhagen N,; Denmark.
- In the context of clinical therapy with recombinant human interleukin-2 ( IL-2 ), we monitored immunological alteration in 10 human immunodeficiency virus type-I (HIV-1)-infected individuals, on stable antiretroviral therapy, who had a CD4+ cell count between 200 and 500
- Recruitment of monocyte derived dendritic cells ex vivo from SIV infected and non-infected cynomolgus monkeys.
- Scand J Immunol. 2000 Feb;51(2):186-94. Unique Identifier : AIDSLINE MED/20118065
- Soderlund J; Nilsson C; Ekman M; Walther L; Gaines H; Biberfeld G; Biberfeld P; Immunopathology Laboratory, Karolinska Institutet, Stockholm,; Sweden.
- This study shows that characteristic dendritic, antigen presenting cells, can be generated from adherent peripheral blood mononuclear cells (PBMC)/monocytes of uninfected and SIVsm-infected cynomolgus monkeys after stimulation in vitro with granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin (IL)
- Early changes in peripheral blood T cell subsets induced by antiretroviral treatment of human immunodeficiency virus-1 positive individuals.
- Scand J Immunol. 2000 Feb;51(2):195-201. Unique Identifier : AIDSLINE MED/20118066
- Dyrhol-Riise AM; Brantsaeter AB; Dunlop O; Baklien K; Skar AG; Asjo B; Bruun JN; Rosok BI; Center for Research in Virology, Department of Microbiology and; Immunology, The Gade Institute, University of Bergen, Norway.
- Human immunodeficiency virus (HIV)-1 infection causes a gradual decline in peripheral blood CD4+ T cells. Shortly after the primary infection, an expansion of the activated memory CD8+ T-cell pool is also observed paralleling increased levels of plasma viraemia. In the present study we investigated the immediate effec
- [Spontaneous bacterial peritonitis with Streptococcus constellatus in an HIV positive patient]
- Schweiz Med Wochenschr. 2000 Jan 22;130(3):72-6. Unique Identifier : AIDSLINE MED/20147507
- Bielecki JW; Gsteiger C; Briner V; Medizinische Klinik, Kantonsspital Luzern.
- Liver diseases are an important cause of high morbidity and mortality in HIV-infected patients, and liver cirrhosis is the commonest cause of ascites in this population. We describe the case of a 38-year-old HIV-positive male (CDC stage B3, CD4 cell count 199/mm3) with a history of hepatitis C-associated liver cirrhos
- Gene patents. Patent on HIV receptor provokes an outcry [news]
- Unique Identifier : AIDSLINE MED/20178783
- Marshall E
- [Research on inflammatory mediators in asthma: new therapeutic approaches]
- Therapie. 1999 Jul Aug;54(4):447-61. Unique Identifier : AIDSLINE MED/20131763
- Magnan A; Molimard M; Braunstein G; Devillier P; Service de Pneumologie, Hopital Sainte Marguerite, Marseille,; France.
- During the National Meeting of Clinical Pharmacology (Giens 1998), the working group exchanged information and examined the new therapeutic approaches to inflammation in asthma. The group performed a state of the art review of the current research on mediators of bronchial inflammation to determine new pharmacological
- Ocular myositis and diffuse meningoencephalitis from Trypanosoma cruzi in an AIDS patient.
- Trans R Soc Trop Med Hyg. 1999 Sep-Oct;93(5):535-6. Unique Identifier : AIDSLINE MED/20161405
- dos Santos S de S; Almeida GM; Monteiro ML; Gemignani P; Duarte MI; Toscano CM; Barone AA; Department of Infectious and Parasitic Diseases, Faculdade de; Medicina da Universidade de Sao Paulo, Brazil.
- Histoplasmosis in eastern India: the tip of the iceberg?
- Trans R Soc Trop Med Hyg. 1999 Sep-Oct;93(5):540-2. Unique Identifier : AIDSLINE MED/20161407
- Goswami RP; Pramanik N; Banerjee D; Raza MM; Guha SK; Maiti PK; Department of Tropical Medicine, Calcutta School of Tropical; Medicine, West Bengal, India.
- Systemic histoplasmosis has various clinical presentations and is of especially concern in immunocompromised patients. A high index of suspicion is required for its diagnosis. A total of 38 cases had been reported from India up to 1996. The most frequent occurrence of cases was arou
- Committee report. Nucleic acid amplification testing of blood donors for transfusion-transmitted infectious diseases: Report of the Interorganizational Task Force on Nucleic Acid Amplification Testing of Blood Donors.
- Transfusion. 2000 Feb;40(2):143-59. Unique Identifier : AIDSLINE MED/20150314
- Busch MP; Kleinman SH; Jackson B; Stramer SL; Hewlett I; Preston S
- Passive transfer of HIV-1 antibodies and absence of HIV infection after the transfusion of HIV-1-seropositive red cells [letter]
- Transfusion. 2000 Feb;40(2):252-3. Unique Identifier : AIDSLINE MED/20150327
- Salomao R; Oliveira JS; Oliveira CF; Diaz RS; Minelli H; Valdetaro F
- Blood component recalls in the United States, 1998 [letter]
- Transfusion. 2000 Feb;40(2):253-4. Unique Identifier : AIDSLINE MED/20150328
- Ramsey G; Sherman LA
- Do intravenous immunoglobulin products manufactured from plasma collected in Italy place immunocompromised patients at risk of contracting human herpesvirus 8? [letter]
- Transfusion. 2000 Feb;40(2):258-9. Unique Identifier : AIDSLINE MED/20150331
- Cristiano K; Wirz M; Gentili G
- Effect of hepatitis C virus coinfection on liver function of patients infected with HIV.
- Trop Gastroenterol. 1999 Jul-Sep;20(3):128-30. Unique Identifier : AIDSLINE MED/20159743
- Sud A; Wanchu A; Bambery P; Singh S; Chawla Y; Postgraduate Institute of Medical Education and Research,; Chandigarh, India.
- AIMS: Both the human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) share similar routes for their transmission, encouraging the possibility of a coinfection with the two viruses in some individuals. We wanted to find out the prevalence of HCV in patients infected with the HIV virus. METHODS: We tested 57 HI
- [Inhibition of nuclear import of HIV-1 Vpr protein by Gag polyprotein in the process of virus-like particles formation]
- Vopr Virusol. 1999 Nov-Dec;44(6):261-5. Unique Identifier : AIDSLINE MED/20128446
- Chikova AK; Lideman LF; Iordanskii SN; Gibadulin RA
- For studies of intracellular Vpr transport and the effect of the HIV-1 Gag polyprotein on the process, a recombinant baculovirus strain was constructed, which directs the synthesis of Vpr fused with the baculovirus secretory polypeptide. During infection the majority of Vpr has been observed in the cell nuclear fracti
- Building and testing an effective HIV vaccine.
- West J Med. 1999 Nov-Dec;171(5-6):363-5. Unique Identifier : AIDSLINE MED/20104071
- Kahn J; Positive Health Program, San Francisco General Hospital, CA; 94110, USA. JKahn@sfaids.ucsf.edu
- What about the ethics?
- West J Med. 1999 Nov-Dec;171(5-6):365-6. Unique Identifier : AIDSLINE MED/20104072
- Wolf LE; Lo B; Center for AIDS Prevention Studies and the Program in Medical; Ethics, University of California, San Francisco 94143, USA.; lwolf@medicine.ucsf.edu
- Apricot orchards: doctors and patients in Japan [letter]
- West J Med. 1999 Nov-Dec;171(5-6):388. Unique Identifier : AIDSLINE MED/20184638
- Feldman M
- When AIDS became a chronic disease.
- West J Med. 2000 Feb;172(2):130-3. Unique Identifier : AIDSLINE MED/20157767
- Scandlyn J; Department of Anthropology, University of Colorado, Denver; 80218-4011, USA. Jsint@aol.com
- Epidemiology of feline leukaemia and feline immunodeficiency virus infections in the Czech Republic.
- Zentralbl Veterinarmed [B]. 1999 Dec;46(10):665-71. Unique Identifier : AIDSLINE MED/20140552
- Knotek Z; Hajkova P; Svoboda M; Toman M; Raska V; Small Animal Clinic, Faculty of Veterinary Medicine, University; of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
- Commercial serological sets were used for the examination of 727 cats kept in larger towns of the Czech Republic . FeLV antigen and antibodies to FIV were demonstrated in 96 (13.2%) and 42 (5.8%) of the animals, respectively. Seven (0.96%) animals were positive for both FeLV
- HIV transmission in children :news
- Am Fam Physician. 2000 Feb 15;61(4):1205-6. Unique Identifier : AIDSLINE MED/20168679
- Preboth M
- NIAID renews funding for the adult AIDS clinical trials group :news
- Am Fam Physician. 2000 Feb 15;61(4):940. Unique Identifier : AIDSLINE MED/20168664
- Sweeney R; Rose VL
- Role of T lymphocytes in renal disease in HIV-transgenic mice.
- Am J Kidney Dis. 2000 Mar;35(3):408-17. Unique Identifier : AIDSLINE MED/20160413
- Shrivastav S; Cusumano A; Kanno Y; Chen G; Bryant JL; Kopp JB; Kidney Disease Section, Metabolic Diseases Branch, National; Institute of Diabetes and Digestive and Kidney Diseases, and Oral; Infection and Immunity Branch, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD, USA.
- The pathogenesis of human immunodeficiency virus (HIV)-associated focal segmental glomerulosclerosis (FSGS) has remained obscure. It has been proposed that renal parenchymal cells may be infected with HIV-1. If such infection occurs, the target cells would be expected to express viral proteins and thus could be target
- Acute renal failure with interstitial nephritis in a patient with AIDS.
- Am J Kidney Dis. 2000 Mar;35(3):557-61. Unique Identifier : AIDSLINE MED/20160435
- Mouratoff JG; Tokumoto J; Olson JL; Chertow GM; Divisions of Nephrology, Moffitt-Long Hospitals, and UCSF-Mt.; Zion Medical Center, Departments of Medicine and Pathology,; University of California, San Francisco, CA 94143-0532, USA.
- Decrease in methodone levels with nelfinavir mesylate [letter]
- Am J Psychiatry. 2000 Mar;157(3):481. Unique Identifier : AIDSLINE MED/20163966
- McCance-Katz EF; Farber S; Selwyn PA; O'Connor A
- HIV incidence among injection drug users in New York City, 1992-1997: evidence for a declining epidemic.
- Am J Public Health. 2000 Mar;90(3):352-9. Unique Identifier : AIDSLINE MED/20170029
- Des Jarlais DC; Marmor M; Friedmann P; Titus S; Aviles E; Deren S; Torian L; Glebatis D; Murrill C; Monterroso E; Friedman SR; Beth Israel Medical Center, New York, NY 10003, USA.
- OBJECTIVES: We assessed recent (1992-1997) HIV incidence in the large HIV epidemic among injection drug users in New York City. METHODS: Data were compiled from 10 separate studies (N = 4979), including 6 cohort studies, 2 repeat service user studies, and 2 analyses of voluntary HIV testing and counseling services w
- Hospitalization of homeless persons with tuberculosis in the United States.
- Am J Public Health. 2000 Mar;90(3):435-8. Unique Identifier : AIDSLINE MED/20170045
- Marks SM; Taylor Z; Burrows NR; Qayad MG; Miller B; Division of Tuberculosis Elimination, National Center for HIV,; STD, and TB Prevention, Centers for Disease Control and; Prevention, Atlanta, Ga. 30333, USA. sgm3@cdc.gov
- OBJECTIVES: This study assessed whether homeless patients are hospitalized for tuberculosis (TB) more frequently and longer than other patients and possible reasons for this. METHODS: We prospectively studied hospitalizations of a cohort of TB patients. RESULTS: HIV-infected homeless patients were hospitalized more fr
- Histopathologic features of progression in Mediterranean and immunodeficiency-related Kaposi sarcoma [letter]
- Am J Dermatopathol. 2000 Feb;22(1):89-91. Unique Identifier : AIDSLINE MED/20162052
- Castelli E; Wollina U
- Survey on attitudes toward HIV-infected individuals and infection control practices among dentists in Mexico City.
- Am J Infect Control. 2000 Feb;28(1):21-4. Unique Identifier : AIDSLINE MED/20143409
- Maupome G; Acosta-Gio E; Borges-Yanez SA; Diez-de-Bonilla FJ; Faculty of Dentistry, University of British Columbia, Vancouver,; Canada.
- BACKGROUND: The teaching of infection control is gradually being introduced at dental schools in Mexico. However, most practicing dentists have limited access to current infection control standards. Deficiencies of knowledge with regard to blood-borne pathogens such as HIV and hepatitis B virus may influence attitudes
- [Motivations of requests for human immunodeficiency virus (HIV) infection screening at the Centers of Information and Anonymous and Free-of-Charge Screening. Study of 891 cases]
- Ann Med Interne (Paris). 1999 Dec;150(8):591-3. Unique Identifier : AIDSLINE MED/20151255
- Pages B; Vergnon P; Claudy A; Misery L; Clinique Dermatologique, Hopital Edouard-Herriot, Lyon.
- In France , human immunodeficiency virus (HIV) testing is usually performed in centers for information and anonymous cost-free detection (Centres d Information et de Depistage Anonyme et Gratuit, CIDAG). In this work, we studied the reasons people ask for HIV testing at the CIDAG in
- [Human immunodeficiency virus resistance to antiretroviral drugs]
- Ann Med Interne (Paris). 1999 Dec;150(8):615-22. Unique Identifier : AIDSLINE MED/20151259
- Karmochkine M; Descamps D; Service d'Immunologie Clinique, Hopital Broussais, Paris.
- Antiretroviral compounds can select viral strains presenting mutations of the HIV genome. Certain genotypic modifications are expressed by phenotypic resistance. There is no cross resistance between different classes of compounds (nucleosides, non nucleosides, antiproteases), but cross resistance is common within a gi
- Neuroprotective strategies for HIV-1-associated neurologic disease.
- Ann N Y Acad Sci. 1999;890:312-3. Unique Identifier : AIDSLINE MED/20133615
- Gelbard HA; Department of Neurobiology, University of Rochester, NY; 14642-8677, USA. hgelbard@neurology.rochester.edu
- Paediatric hospital admissions at a South African urban regional hospital: the impact of HIV, 1992-1997.
- Ann Trop Paediatr. 1999 Jun;19(2):135-42. Unique Identifier : AIDSLINE MED/20154843
- Zwi KJ; Pettifor JM; Soderlund N; Department of Paediatrics, Chris Hani Baragwanath Hospital, South; Africa. kzwi@icon.co.za
- Rates of infection by the human immunodeficiency virus (HIV) have been increasing rapidly in South Africa over the last decade. This study documents the changes over time in prevalence of HIV infection amongst hospitalized children, and its effects on the profile of disease and in
- Knowledge of and attitudes to HIV/AIDS of senior secondary school pupils and trainee teachers in Udupi District, Karnataka, India.
- Ann Trop Paediatr. 1999 Jun;19(2):143-9. Unique Identifier : AIDSLINE MED/20154844
- Agrawal HK; Rao RS; Chandrashekar S; Coulter JB; Tropical Child Health, Liverpool School of Tropical Medicine, UK.
- A cross-sectional descriptive study using a questionnaire with mostly closed-ended questions was carried out on 990 pupils and 46 trainee teachers to investigate their knowledge of and attitudes to HIV/AIDS. Pupils in one school were reassessed after a health talk and distribution of a handout. Despite having had no f
- Serum levels of measles IgG antibody activity in children under 5 years in Dar-es-Salaam, Tanzania.
- Ann Trop Paediatr. 1999 Jun;19(2):175-83. Unique Identifier : AIDSLINE MED/20154848
- Lyamuya EF; Matee MI; Aaby P; Scheutz F; Department of Microbiology/Immunology, Muhimbili University,; College of Health Sciences, Dar-es-Salaam, Tanzania.; hdmim@muchs.ac.tz
- Measles IgG antibody levels were estimated in sera from 685 Tanzanian children, 374 (54.6%) boys and 311 (45.4%) girls aged 18 months to 5 years, using an enzyme-linked immunosorbent assay (ELISA). The children were screened for HIV-1 and 2 antibodies using ELISA, and reactive sera were confirmed by Western blot. Nutr
- Lentivirus replication and regulation.
- Annu Rev Genet. 1999;33:133-70. Unique Identifier : AIDSLINE MED/20154996
- Tang H; Kuhen KL; Wong-Staal F; Department of Medicine and Biology, University of California, San; Diego 92093-0665, USA. htang@biomail.ucsd.edu
- Lentiviruses are associated with chronic diseases of the hematological and neurological systems in animals and man. In particular, human immunodeficiency virus type 1 (HIV-1) is the etiological agent of the global AIDS epidemic. The genomes of lentiviruses are complex, encoding a number of regulatory and accessory pro
- Antiviral properties of a mangrove plant, Rhizophora apiculata Blume, against human immunodeficiency virus.
- Antiviral Res. 1999 Dec 15;44(2):113-22. Unique Identifier : AIDSLINE MED/20132745
- Premanathan M; Arakaki R; Izumi H; Kathiresan K; Nakano M; Yamamoto N; Nakashima H; Department of Microbiology and Immunology, Kagoshima University; Dental School, Japan.
- A polysaccharide extracted from the leaf of Rhizophora apiculata (RAP) was assessed in cell culture systems, for its activity against human and simian immunodeficiency viruses. RAP inhibited HIV-1 or HIV-2 or SIV strains in various cell cultures and assay systems. It blocked the expression of HIV-1 antigen in MT-4 cel
- Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system.
- Arch Biochem Biophys. 2000 Feb 15;374(2):334-8. Unique Identifier : AIDSLINE MED/20132872
- Veldman CM; Cantorna MT; DeLuca HF; Department of Biochemistry, University of Wisconsin-Madison,; Madison, Wisconsin 53706, USA.
- In addition to its role in calcium and skeletal homeostasis, there is increasing evidence that the hormonal form of vitamin D, 1, 25-dihydroxyvitamin D(3), appears to serve as a modulator of the immune system. We have determined the level of the 1, 25-dihydroxyvitamin D(3) receptor (VDR) in resting and activated lymph
- Blood screening--the next generation in testing [editorial]
- Aust N Z J Med. 1999 Dec;29(6):763-4. Unique Identifier : AIDSLINE MED/20140288
- Chappel RJ; Dax EM
- Computational design of new cyclic urea inhibitors for improved binding of HIV-1 aspartic protease.
- Biochem Biophys Res Commun. 2000 Feb 16;268(2):384-9. Unique Identifier : AIDSLINE MED/20145442
- Kotamarthi B; Bonin I; Benedetti F; Miertus S; International Centre for Science and High Technology, UNIDO,; Trieste, Italy.
- We report in this paper the design, by means of computational techniques, of new cyclic urea inhibitors of the HIV aspartic protease. The relationship between the complexation energies of the enzyme with known inhibitors and the experimentally determined log K(i) have been studied and used to predict inhibition consta
- Identification of a nuclear ribonucleoprotein particle which contains incompletely spliced HIV-1 RNAs.
- Biochem Biophys Res Commun. 2000 Feb 16;268(2):509-13. Unique Identifier : AIDSLINE MED/20145464
- Boe SO; Kalland KH; Center for Research in Virology, Department of Microbiology and; Immunology, The Gade Institute, University of Bergen, Bergen High; Technology Center, Bergen, N-5020, Norway. Stig.boe@vir.uib.no
- Unspliced and partially spliced HIV RNAs are transported to the cytoplasm by the HIV encoded Rev protein. In the present study, a ribonucleoprotein complex which contains such incompletely spliced HIV RNA is identified. Soluble nuclear extracts were prepared from the lymphocyte cell line H9/IIIB that constitutively pr
- Dismissing the threat: maladaptive coping with AIDS- prevention messages.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 101). Unique Identifier : AIDSLINE AIDS/20710037
- Blemberg SJ; DHHS/CDC, National Center for Health Statistics, Hyattsville, MD.; Fax: (301) 436-3484.
- ISSUE: Within many HIV risk-reduction programs, students learn several threatening facts about HIV infection and AIDS. When these facts are reinforced with discussions about students risk for contracting the disease, intense anxiety should develop. These programs then hope that the anxiety will be a motivating force
- Public/private partnerships in HIV/STD risk reduction: bar outreach targeting men who have sex with men.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 102). Unique Identifier : AIDSLINE AIDS/20710038
- Schulze F; Pennsylvania Department of Health, Williamsport. Fax: (570); 327-3748. E-mail: rschulze@health.state.pa.us.
- ISSUE: Men who have sex with men are at increased risk acquisition of HIV/STD s due to risk factors of unprotected anal intercourse, multiple sex partners, sex while under the influence of drugs/alcohol, history of STD s and perceived lack of susceptibility in rural regions. Further, rural and small city men who have
- Trends in HIV-related risk behaviors among high school students--selected U.S. cities, 1991-1997.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 103). Unique Identifier : AIDSLINE AIDS/20710039
- Brener ND; Kinchen S; Everett SE; Kann L; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (770) 488-3112. E-mail: nad1@cdc.gov.
- BACKGROUND/OBJECTIVES: HIV-related risk behaviors among high school students have been decreasing nationwide during the 1990s. To determine whether these same trends hold in urban areas hardest hit by the HIV epidemic, we analyzed data from Youth Risk Behavior Surveys (YRBS) conducted in eight large cities in 1991, 19
- The informed consumer, the road to a healthier, happier, and safer life.
- Unique Identifier : AIDSLINE AIDS/20710040
- Lennox-Smith JL
- ISSUE: Too little emphasis is placed on secondary prevention and consumer education, while much time and effort is spent on prevention education on those not infected or even affected by HIV AIDS, and often do not feel that they are at risk. Primary prevention education is critical to prevent the spread of HIV, but no
- Management of intravaginal warts in HIV-infected women with a dual combination therapy: 5-Fluorouracil (L%) in injectable hydrophilic gel and Zidovudine 250 mg.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 105). Unique Identifier : AIDSLINE AIDS/20710041
- Sved TA; Quresh ZA; Ahmad SA; Shahida M; University of California, Department of Dermatology, San; Francisco. Fax: (415) 753-5304. E-mail: tasyed@itsa.ucsf.edu.
- OBJECTIVE: The aim of this placebo-controlled, double- blinded study was to evaluate the clinical efficacy and tolerability of5-Fluorouracil (1%) incorporated in a hydrophilic gel to cure intravaginal warts in HIV-infected women who were already on an oral regimen of Zidovudine (250 mg.), twice daily three time a week
- HIV/AIDS risk behaviors among Native American high school students.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 106). Unique Identifier : AIDSLINE AIDS/20710042
- Geboe C; Everett SA; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (770) 488-3112. E-mail: sce2@cdc.gov.
- BACKGROUND/OBJECTIVES: The Youth Risk Behavior Survey (YRBS) was administered to students in Bureau of Indian Affairs (BIA) funded high schools nationwide to determine the prevalence of health risk behaviors among Native American students attending these schools. METHODS: BIA conducted a census of schools and students
- Designing, evaluating and expanding programs to rural and suburban sex workers.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 107). Unique Identifier : AIDSLINE AIDS/20710043
- Tkachik A; Gardner, IL. Fax: (815) 237-0136.
- ISSUE: Literature in print on programs to sex workers are programs and interventions specific to inner city issues. SETTING: Community based, not-for-profit, peer led agency in the mid-west (suburban and rural) delivering HIV prevention and testing to sex-workers and IDU s. PROJECT: A peer founded, governed, directed
- Effective sexual health education in hard to reach populations.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 108). Unique Identifier : AIDSLINE AIDS/20710044
- Giffin M; Larson K; Alaskan AIDS Assistance Association, Anchorage, AK. Fax: (907); 263-2051. E-mail: ahmcg@uaa.alaska.edu.
- ISSUE: Delivering HIV prevention education in Anchorage presents the challenges of reaching diverse and disenfranchised populations. In Alaska, these groups are represented by women and youth in treatment as well as immigrant populations. SETTING: The intended audience is youth and women of color in substance abuse tr
- A novel mechanism of oral transmission of HIV by infected seminal fluid and milk.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 109). Unique Identifier : AIDSLINE AIDS/20710045
- Baron S; Poast J; Richardson CJ; Nguyen D; Cloyd M; University of Texas Medical Branch, Department of Microbiology; and Immunology, Galveston. Fax: (409) 772-5065. E-mail:; sabaron@tmb.edu.
- BACKGROUND: Salivary transmission by the 30 million carriers is a rare event despite kissing, aerosolization, and dental treatment. The main salivary protective mechanism has been reported to be due to inactivation of the HIV-infected leukocytes in the mouth by the unique hypotonicity of saliva, resulting in a 10,000-
- Published HIV/AIDS information--a knowledge base for service providers at the community level.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 110). Unique Identifier : AIDSLINE AIDS/20710046
- Newby LC; HIV Resource Library, New York City Department of Health, NY.; Fax: (212) 693-1307. E-mail: hivlibrary@compuserve.com.
- ISSUE: Program managers and their staff need published information to provide effective and efficient service to their clientele. There is a wealth of information available but there needs to be some coordination and promotion of these resources in order for maximum use to be made of them. Programs are being funded to
- Among friends: crisis transition program for GLBTs.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 111). Unique Identifier : AIDSLINE AIDS/20710047
- Kraft JD; Among Friends Job Support Group, Vienna, VA. Fax: (703) 281-; 3762. E-mail: jkraft715#aol.com.
- ISSUE: Among Friends is a non-profit, incorporated ministry to GLBT persons in crisis. It provides short-term housing (3 to 6 months), a job search support group, and a peer- counseling program. This poster is presented as a model for similar local program development. The house has a permanent house mother and can
- Maximizing PIR in community prevention planning.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 112). Unique Identifier : AIDSLINE AIDS/20710048
- Leedom S; Rivera H; Washington, DC. Fax: (202) 898-0435. E-mail: hrivera@napwg.org.
- ISSUE: Parity, Inclusion and Representation are key components for the success of CPG when addressing community needs. Studies and documents from the USC Conference of Mayors (HIV Prevention Community Planning Profiles-1998), USMBHA (Taking a Closer Look: An Assessment of HIV Prevention Community Planning Groups-1997)
- High-risk sexual behaviors among HIV-infected adolescents and young adults.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 113). Unique Identifier : AIDSLINE AIDS/20710049
- Denning PH; Nakashima AK; Wortley P; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-2980. E-mail: pbdO@cdc.gov.
- OBJECTIVE: To describe high-risk sexual behaviors among adolescents and young adults recently reported with HIV infection or AIDS, and to determine risk factors associated with these behaviors. METHODS: Between January 1995 and November 1998, we interviewed 1,446 persons aged 18-29 years who were newly reported with H
- Communities at risk-estimating the impact of the HIV epidemic upon adolescents and adults at the local level.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 114). Unique Identifier : AIDSLINE AIDS/20710050
- Denning P; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-2980. E-mail: pbd0@cdc.gov.
- BACKGROUND: Since HIV-infected persons who develop AIDS by age 25 tend to have been recently infected, trends in AIDS incidence among these young persons will closely parallel trends in HIV incidence. AIDS incidence data for persons aged 18-25 years can thus provide a population-based means of estimating recent patter
- Addressing HIV/AIDS in the workplace.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 115). Unique Identifier : AIDSLINE AIDS/20710051
- Laporte Y; Williams R; Milan J; Petesch P; Benson B; Monford J; Washington, DC. Fax: (202) 296-3727. E-mail:; yolan.laporte@dc.ogilvypr.com.
- ISSUE: The American workplace has been profoundly affected by HIV/AIDS, and advanced medical treatments promise to bring more challenges. As optimism flourishes, the urgency surrounding the epidemic dissipates, and the resolve to maintain preventive behaviors potentially becomes weaker. Many workplaces are unprepared
- Understanding the culture of masculinity and creating effective prevention messages.
- Unique Identifier : AIDSLINE AIDS/20710052
- William P; Britton C; North Carolina Department of Health and Human Services, HIV/STD
- ISSUE: CDC standards for effective HIV prevention messages require cultural appropriateness and Sensitivity and are focused on risk reduction behaviors that curtail and/or alter sexual behaviors. The professional literature and prevention programs seldom acknowledge or account for the impact of the culture of masculin
- Rapid HIV testing vs. traditional testing: in a public health outreach setting.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 117). Unique Identifier : AIDSLINE AIDS/20710053
- Bennett SB; Fordan S; Buff EE; Haddock-Morilla L; Caldwell R; Hill L; Williams D; Retrovirology Unit, Florida Department of Health, Bureau of; Laboratories, Jacksonville. Fax: (904) 791-1567.
- OBJECTIVES: To compare the performance of a fingerstick- based HIV rapid test against a traditional serum-based EIA screening assay. This assessment is to target a high volume, high seroprevalent public health outreach setting. We are evaluating this rapid test on the basis of its potential benefit to identify and ass
- Ethnic identify, gay identify, sexual sensation seeking and HIV risk taking among men of color who have sex with men.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 118). Unique Identifier : AIDSLINE AIDS/20710054
- Chng CL; Geliga-Vargas J; University of North Texas, Dallas. Fax: (214) 522-4604. E- mail:; Geliga@Resourcecenterdallas.org.
- BACKGROUND/OBJECTIVES: This study identified relationships among ethnic identity, gay identity, sexual sensation seeking, and HIV risk-taking behaviors among MSM of color. The following hypotheses were investigated: 1) MSM of color who report high ethnic identity will report significantly more HIV risk-taking behavior
- National assessment of the technical assistance needs of Asian and Pacific Islander HIV prevention programs.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 119). Unique Identifier : AIDSLINE AIDS/20710055
- Bau I; Asian and Pacific Islander American Health Forum, San Francisco,; CA. Fax: (415) 954-9999. E-mail: ibau@apiahf.org.
- BACKGROUND/OBJECTIVES: Asians and Pacific Islanders (APIs) are one of the fastest growing populations in the U.S. Although the reported number of AIDS cases remain relatively low among APIs, rapid population growth and the diversity of API languages and cultures make HIV prevention in these communities particularly ch
- Protection from STD, HIV/AIDS, and unintended pregnancy implications: for multiple method use.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 120). Unique Identifier : AIDSLINE AIDS/20710056
- Wilson TE; Hogben M; Minkoff H; SUNY Downstate Medical Center, Brooklyn, NY. Fax: (718) 270-; 3386. E-mail: Twilson@netmail.hsckblyn.edu.
- OBJECTIVE: To identify psychosocial antecedents and behavioral outcomes associated with the use of dual methods of contraception (i.e., a condom plus one other method). METHODS: 1,050 sexually active women reported attitudes toward pregnancy/STD, sexual behaviors, STI: history, and were asked to rate condom attributes
- Mandatory HIV testing of infants and rates of follow-up.
- Unique Identifier : AIDSLINE AIDS/20710057
- Wilson T; Minkoff H
- OBJECTIVE: In 1996, New York State passed legislation that would unblind previously anonymous results of newborn heelstick serosurveys used to track rates of HIV infection among childbearing women and infants. Concerns arose that women who do not wish to learn their serostatus might be deterred seeking infant care i
- Current reproductive health and HIV prevention issues for incarcerated women.
- Unique Identifier : AIDSLINE AIDS/20710058
- de Ravello L
- BACKGROUND: In 1997, almost 80,000 women were incarcerated in over 300 State and Federal correctional facilities, 60,000 women were held daily in county and local jails, and 748,000 female juvenile arrests were made in the United States . Although women make up less than 10% of the tota
- Survival of AIDS patients according to injecting drug use in a cohort of Puerto Rican AIDS patients according to injecting drug use in a cohort of Puerto Rican AIDS patients.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 123). Unique Identifier : AIDSLINE AIDS/20710059
- Fernandez DM; Gomez MA; Velazquez M; Mayor M; Gomez O; Hunter RF; Retrovirus Research Center, Internal Medicine Department,; Universidad Central del Caribe, Bayamon, Puerto Rico. Fax: (787); 787-8733.
- OBJECTIVES: This paper aims to: (1) describe IDU s and non- IDU s according to age, gender, AIDS criteria and antiretroviral use; and (2) assess survival differences between IDU s and non-IDU s according to age, gender, AIDS diagnosis criteria and antiretroviral use. METHODS: This study is a survival study of a longit
- HIV/AIDS in a late-middle aged and elderly Puerto Rican population.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 127). Unique Identifier : AIDSLINE AIDS/20710060
- Gomez MA; Hunter R; Minino A; Retrovirus Research Center, Internal Medicine Department,; Universidad Central Del Caribe, Bayamon, Puerto Rico. Fax: (787); 787-8733. E-mail: mgomez@caribe.net.
- OBJECTIVES: To characterize and describe HIV-infected patients of advanced age who seek health services at the public facilities of the health region of Bayamon, Puerto Rico and to compare this population with the younger sample complement. METHODS: A subsample of subjects (n=1
- HIV risk scenario among Puerto Rican HIV/AIDS women.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 128). Unique Identifier : AIDSLINE AIDS/20710061
- Gomez MA; Fernandez DM; Hunter R; Internal Medicine Department, Universidad Central Del Caribe,; Bayamon, Puerto Rico. Fax: (787) 787-8733. E-mail:; mgomez@caribe.net.
- OBJECTIVE: To assess the socio-demographic, behavioral, psychological, clinical and immunological differences of Puerto Rican HIV/AIDS women sample according to their HIV transmission mode. DESIGN: Cross-sectional survey of a longitudinal cohort (n=1,901). METHODS: The HIV Central Registry of the Universidad Central d
- Behavioral intervention research on alcohol and AIDS.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 129). Unique Identifier : AIDSLINE AIDS/20710062
- Bryant KJ; National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.; Fax: (301) 443-8774. E-mail: Kbryant@willco.niaaa.nih.gov.
- ISSUE: The National Institute on Alcohol Abuse and Alcoholism (NIAAA) supports a comprehensive research program on the relationship of alcohol abuse and the risk of HIV infection. The interrelationships between alcohol abuse and HIV risk behaviors are complex. To stem the HIV epidemic, it is critical to develop knowle
- Improving failure to return rates with men who have sex with men-HIV counseling and testing in gay bars and sex parks.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 131). Unique Identifier : AIDSLINE AIDS/20710063
- Charles M; Community AIDS Resource & Education Services, Kalamazoo, MI. Fax:; (616) 381-6048. E-mail: Mark@CARESSWM.ORG.
- ISSUE: Recent directives from the Center for Disease Control require grantees to have no less than a 90% return rate for seropositive test results, and no less than 75% for high- risk seronegatives. Agencies that fail to achieve these standards must then document their low return rates and take additional steps to imp
- The unsafe sexual behavior of persons living with HIV/AIDS: an empirical approach to developing new HIV prevention interventions targeting HIV-positive persons.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 132). Unique Identifier : AIDSLINE AIDS/20710064
- Rosser BR; Gobby JM; Striepe M; Department of Family Practice and Community Health, Medical; School, University of Minnesota, Minneapolis. Fax: (612); 628-8311.
- BACKGROUND/OBJECTIVES: This study aims to examine the psychosexual concerns of persons living with HIV in order to develop new HIV prevention interventions. METHODS: In all, 106 persons living with HIV/AIDS in Minnesota completed an anonymous survey that examined risk behavior at time of infection, pre-diagnosis, post
- Lowering internalized homophobia in men who have sex with men: a randomized controlled trial.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 133). Unique Identifier : AIDSLINE AIDS/20710065
- Rugg DL; Rosser BR; Ross MW; Bockting WO; Kraft C; Bauer G; Robinson BE; Coleman E; Centers for Disease Control and Prevention, National Center for; HIV, STD, and TB Prevention, Atlanta, GA. Fax: (404) 639-1950.; E-mail: dlr3@cdc.gov.
- BACKGROUND OBJECTIVES: Can internalized homophobia, a major cofactor hypothesized as mediating risk behavior in men who have sex with men (MSM), be reduced? This question was studied as part of a wider study evaluating an innovative approach to HIV prevention. METHODS: MSM volunteers (N=443) were randomly assigned to
- Safer sex and unsafe sex behavior in a seminar-based sample of midwestern men who have sex with men (1994-1997).
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 134). Unique Identifier : AIDSLINE AIDS/20710066
- Rosser BR; Bauer GR; Bockting WO; Welles SL; Department of Family Practice and Community Health, Medical; School, University of Minnesota, Minneapolis. Fax: (612); 628-8311.
- BACKGROUND/OBJECTIVES: Recent studies based in areas of high HIV prevalence have reported increases in unsafe sex among men who have sex with men (MSM), and have attributed this to behavioral relapse resulting from HIV/AIDS anti-retroviral therapy. This study examines safer sex behavior, unsafe sexual behavior and c
- AIDS in the deaf community.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 135). Unique Identifier : AIDSLINE AIDS/20710067
- Lester MR; Dekalb County Boardoff Deaf Health, Decatur, GA. Fax: (404); 294-3842. E-mail: Maryl@PH.dr.ga.state.us.
- ISSUE: HIV/AIDS continues to be a major problem in the deaf community. Although public health agencies do not record statistics regarding incidence of AIDS cases among the deaf, it is known that deaf people practice the same risk behaviors that cause hearing persons to become infected: primarily, unprotected sex and s
- An evaluation of an integrative HIV prevention education model for Latinas.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 136). Unique Identifier : AIDSLINE AIDS/20710068
- Munoz L; Congreso de Latinos Unidos, Philadelphia, PA. Fax: (215); 763-7023. E-mail: Lorenam@Congreso.net.
- ISSUE: Despite the over-representation of Latinas in the AIDS epidemic, traditional HIV/AIDS prevention programs are often designed to provide standard HIV/AIDS information to participants such as transmission through sexual practices and IV drug use. Most prevention programs lack an analysis of race, class and gender
- Accuracy of newer whole-blood rapid HIV tests.
- Unique Identifier : AIDSLINE AIDS/20710069
- Branson BM; Fridlund C; Granade T; Phillips S; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-2029. E-mail: BMB2@cdc.gov.
- OBJECTIVE: To evaluate the sensitivity and specificity of recently developed-HIV rapid tests which can be performed on whole blood by persons with minimal technical training. METHODS: Five investigational rapid tests (a) which could be performed on whole blood or fingerstick specimens and (b) whose manufacturers plann
- Adapting a standardized project to meet local needs: the supplement to HIV/AIDS (SHAS) project in Washington state.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 138). Unique Identifier : AIDSLINE AIDS/20710070
- Courogen M; Washington State Department of Health, Olympia. Fax: (360); 586-5440. E-mail: mtc0303@doh.wa.gov.
- ISSUE: HIV/AIDS reports provide limited information about those infected. Data from the supplement to HIV/AIDS Surveillance (SHAS) Project provide enhanced information on important characteristics and needs of the infected population. This information can be used to plan, develop, and monitor HIV prevention interventi
- What's love got to do with it? Quantifying the risk of HIV.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 139). Unique Identifier : AIDSLINE AIDS/20710071
- Varghese B; Maher JE; Peterman TA; Branson B; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-2029. E-mail: bav7@cdc.gov.
- BACKGROUND/OBJECTIVES: In addition to condom use, other HIV prevention approaches are associated with different risks and benefits and would provide more choices to people. We used decision analyses to estimate the relative risks of acquiring HIV on the basis of a person s choice of (a) sex act, (b) condom use, (c) pa
- Using GIS to improve methods of targeting HIV resources to communities in need.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 140). Unique Identifier : AIDSLINE AIDS/20710072
- Egan J; Favuzzi M; Mesh B; Bureau of HIV Prevention, New York City Department of Health, NY.; Fax: (212) 788-4278.
- ISSUE: To make comprehensible huge amounts of information for a diverse constituency by relating complex and disparate data into a meaningful whole: To respond to community demands for information that heretofore was slow to assemble or difficult to communicate: to enhance our planning capacity so as to improve our ma
- Minnesota pharmacy syringe/needle access initiative (SAI)- implementation.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 141). Unique Identifier : AIDSLINE AIDS/20710073
- Novotny G; DeBoer J; Collison E; Nelson R; Moore S; Minnesota Department of Health, Minneapolis. Fax: (612) 676-; 5739. E-mail: GARY.NOUTNY@HEALTH.STATE.MN.US.
- ISSUE: There is overwhelming evidence that syringe access programs reduce HIV-related risk factors among injection drug users and can be implemented without harmful social repercussions. Given the limited political and financial support for needle exchange programs, ensuring pharmacy sales of needles/syringes becomes
- Quality assurance of HIV counseling, testing, and referral services: where do we start?
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 142). Unique Identifier : AIDSLINE AIDS/20710074
- Lindsey T; Bruce A; Jordan R; Manning D; Vonderwabl C; Colorado Department of Public Health and Environment, Denver.; Fax: (303) 78205393.
- ISSUE: Research shows that HIV counseling, testing, and referral (CTR). when presented in a client-centered manner that is tailored to the individual and specific needs of each client, is an effective method of risk reduction and HIV prevention. Many public and private agencies, clinics and community-based organizatio
- Studylink: improving access to clinical research as a prevention method.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 143). Unique Identifier : AIDSLINE AIDS/20710075
- Kennedy AO; Rosenwald V; Clinical Directors Network (CDN-STUDYLINK), New York, NY. Fax:; (212) 382-0669. E-mail: AYISAKENN@AOL.COM.
- ISSUE: Although the NYC metropolitan area has the highest HIV case rate in the US, local clinical research sites sometimes have difficulty filling studies of new treatments. This inability to connect patients with research opportunities may be because most newly diagnosed and infected people live in the outer boroughs
- Skills-based intervention for youth in high risk situations.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 144). Unique Identifier : AIDSLINE AIDS/20710076
- Oldknow L; AIDGwinnett, Lawrenceville, GA. Fax: (770) 962-1291.
- ISSUE: Teens at risk for HIV infection need effective, culturally sensitive interventions to decrease their risk of HIV infection. SETTING: Several locations associated with teen youth in high-risk situations. Locations include the regional Youth Detention Center, Buford Health Center and Gwinnett County court-ordered
- HIV counseling and testing-a new approach.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 145). Unique Identifier : AIDSLINE AIDS/20710077
- Gery EH; New York, NY. Fax: (212) 367-1101.
- ISSUE: HIV counseling and testing helps clients use the knowledge of their HIV status to make decisions towards taking better care of their lives. When linked with prevention and medical services, testing serves as a gateway for individuals to access care without delay, with focus on staying negative if negative, or g
- Economic evaluation of safer choices: a school-based HIV, STD and pregnancy prevention program.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 146). Unique Identifier : AIDSLINE AIDS/20710078
- Wang LY; Davis M; Robin L; Collins J; Banspach S; Parcel G; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (770) 488-3112. E-mail: lgw0@cdc.gov.
- OBJECTIVES: this study evaluated the cost-effectiveness and cost-benefit of Safer Choices, a well-evaluated, school- based HIV/STD, and unintended pregnancy prevention intervention for high school students. METHODS: A societal perspective was used in this study, and cost-effectiveness and cost-benefit were derived thr
- Outcome evaluation of the women's initiative for sexual health: preintervention data.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 147). Unique Identifier : AIDSLINE AIDS/20710079
- Robinson B; Westover BJ; Uhl G; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-0929. E-mail: bjw0@cdc.gov.
- BACKGROUND/OBJECTIVES: The Women s Initiative for Sexual Health (WISH) is a comprehensive, culturally-specific sexuality education intervention targeting African American women in Minneapolis-St. Paul, MN. This intervention is a collaboration between a university-based human sexuality center and three African-American
- Minnesota pharmacy syringe/needle access initiative (SAI).
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 148). Unique Identifier : AIDSLINE AIDS/20710080
- Novotny G; DeBoer J; Collison E; Nelson R; Moore S; Minneapolis, MN. Fax: (612) 676-5739. E-mail:; GARY.NOVOTNY@HEALTH.STATE>MN.US.
- ISSUE: There is overwhelming evidence that syringe access programs reduce HIV-related risk factors among injecting drug users and can be implemented without harmful social repercussions. Given the limited olitica7 and financial support for needle exchange programs, ensuring pharmacy sales of needles/syringes becomes p
- Prevalence, predictors, and presumptions for never having been HIV tested among young men who have sex with men in seven urban areas.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 149). Unique Identifier : AIDSLINE AIDS/20710081
- Valleroy LA; MacKellar D; Secura G; Magee E; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-2029. E-mail: LAV0@CDC.GOV.
- BACKGROUND/OBJECTIVES: Although young men who have sex with men (YMSM) may be at high risk for becoming HIV-infected or infecting others, their HIV testing behaviors are not well described. Our objectives are to identify the prevalence, the predictors, and the reported reasons for never having been previously HIV-test
- Are negative affective states associated with sexual risk behaviors? A review of T empirical literature with implications for clinical.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 150). Unique Identifier : AIDSLINE AIDS/20710082
- Crepaz N; Marks G; Mansergh G; Centers for Disease Control and Prevention, Division of HIV/AIDS,; Epi Branch, Atlanta, GA. Fax: (404) 639-6118. E- mail:; ncc9@cdc.gov.
- BACKGROUND/OBJECTIVE: Negative affective states (e.g., depressive sympromatology, anxiety, anger, stress, mood disturbance) may promote sexual risk behaviors that lead to HIV infection. This hypothesis has been the focus of many empirical studies. If substantiated, then clinical intervention efforts to alleviate negat
- HIV prevention in the disability community.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 151). Unique Identifier : AIDSLINE AIDS/20710083
- DeRocher TL; BWCIL, Post Huron, MI. Fax: (810) 987-9548. E-mail:; tderocher@hotmail.com.
- ISSUE: Available research suggests that those with developmental, psychiatric and other disabilities are at particularly high risk for contracting STDs generally and HIV as well. However, few resource available to guide prevention efforts with these groups, and fewer still for these groups in rural areas. SETTING: Thi
- Antiretroviral medication adherence among the REACH HIV- infected adolescent cohort.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 152). Unique Identifier : AIDSLINE AIDS/20710084
- Murphy DA; Wilson C; Durako S; Muenz L; Belzer M; University of California Health Risk Reduction Projects, Los; Angeles. Fax: (310) 794-8297. E-mail: dmurphy@mednet.ucla.edu.
- BACKGROUND/OBJECTIVES: HIV-infected adolescents from 16 locations in 13 U.S. cities were recruited into the REACH (Reaching for Excellence in Adolescent Care and Health) project, the first large-scale disease progression study of HIV-positive adolescents infected through sexual behavior or injection drug use. Adherenc
- Targeted opt-in vs. routine opt-out HIV testing in an STD clinic.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 153). Unique Identifier : AIDSLINE AIDS/20710085
- Lee JH; Mitchell B; Nolt B; Robbins B; Thomas MC; Branson BM; Centers for Disease Control and Prevention, Atlanta, GA. Fax:; (404) 639-2029. E-mail: BMB2@cdc.gov.
- BACKGROUND: Despite several strategies for targeting HIV testing, blinded prevalence studies revealed that half of HIV-positive clients in some Texas STD clinics were not tested. OBJECTIVE: To compare the acceptance and effectiveness of a new opt-out approach (routine HIV test included in clinic consent and done on
- HIV prevention education for preservice and beginning classroom teachers.
- Natl HIV Prev Conf. 1999 Aug 29-Sep 1;:(abstract no. 154). Unique Identifier : AIDSLINE AIDS/20710086
- Michael-Bandele M; Wright L; Summerfield LM; AACTE, Washington, DC. Fax: (202) 457-8095. E-mail:; Isummerfield@aacte.org.
- ISSUE: Regular K