2000
- The role of CD4 and CD8 T cells in the development of autoimmune diabetes.
- J Autoimmun. 1999 Nov;13(3):285-90. Unique Identifier : AIDSLINE MED/20019749
- Dilts SM; Solvason N; Lafferty KJ; The John Curtin School of Medical Research, Division of Molecular; Medicine, Australian National University, Canberra, ACT, 0200,; Australia.
- The role of CD4 vs. CD8 T cells in IDDM.
- J Autoimmun. 1999 Nov;13(3):290-5. Unique Identifier : AIDSLINE MED/20019750
- Wong FS; Janeway CA Jr; Section of Immunobiology and Howard Hughes Medical Institute,; Yale School of Medicine, New Haven, CT, 06520-8011, USA.
- Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen.
- Unique Identifier : AIDSLINE MED/20019753
- Garcia G; Komagata Y; Slavin AJ; Maron R; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital,; Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA,; 02115, USA.
- We directly compared the effects of oral and nasal administration of collagen type II (CII) on disease progression, cytokine production and T cell responses in DBA/1 mice. Lymphocytes were assayed for proliferation and cytokine production and cell lines established. T cells from fed or nasally treated groups prolifera
- Anti-phospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome: comparisons of phospholipid specificity, avidity and reactivity with beta2-GPI.
- J Autoimmun. 1999 Nov;13(3):347-55. Unique Identifier : AIDSLINE MED/20019756
- Petrovas C; Vlachoyiannopoulos PG; Kordossis T; Moutsopoulos HM; Department of Pathophysiology, Medical School, National; University of Athens, Athens, Greece.
- Increased prevalence of anti-phospholipid antibodies (aPL) and increased levels of lipid peroxidation have been described in patients with HIV infection. To assess the binding specificity and avidity of aPL antibodies in HIV infection, sera from 44 HIV-1 infected patients were evaluated for antibodies to cardiolipin (
- Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells?
- J Autoimmun. 1999 Dec;13(4):373-82. Unique Identifier : AIDSLINE MED/20054046
- Radosevic K; Casteels KM; Mathieu C; Van Ewijk W; Drexhage HA; Leenen PJ; Department of Immunology, Erasmus University Rotterdam, The; Netherlands. radosevic@immu.fgg.eur.nl
- In this study we have tried to detect abnormalities in the immunophenotype and/or function of dendritic cells from the non-obese diabetic mouse (NOD DC), that might be related to islet autoimmunity. The immunophenotype of NOD splenic DC did not show significant abnormalities as compared with the immunophenotype of spl
- Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-gamma secretion pathway.
- J Autoimmun. 1999 Dec;13(4):383-92. Unique Identifier : AIDSLINE MED/20054047
- Ablamunits V; Quintana F; Reshef T; Elias D; Cohen IR; Department of Immunology, The Weizmann Institute of Science,; Rehovot, 76100, Israel.
- Cyclophosphamide (CY), an alkylating cytostatic drug, is known for its ability to accelerate a number of experimental autoimmune diseases including spontaneous diabetes in NOD mice. The mechanism(s) by which CY renders autoreactive lymphocytes more pathogenic is largely unknown, but it has been postulated that the dru
- Suppression of systemic lupus erythematosus disease in mice by oral administration of kidney extract.
- J Autoimmun. 1999 Dec;13(4):405-14. Unique Identifier : AIDSLINE MED/20054049
- Ofosu-Appiah W; Sfeir G; Viti D; Burashnikova E; Department of Immunology, Masonic Medical Research Laboratory,; Utica, NY 13501, USA. ofosu@mmrl.edu
- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increased production of antibodies reactive with a variety of self and non-self antigens. A number of immunomodulatory therapies have been investigated for the disease process. Intragastric administration of low dose kidney extract (KE) t
- Intracytoplasmic Th1 and Th2 cytokines in rheumatoid arthritis blood and synovial tissue.
- J Autoimmun. 1999 Dec;13(4):415-22. Unique Identifier : AIDSLINE MED/20054050
- Bourg V; Portales P; Fiorito S; Combe B; Jorgensen C; Sany J; Clot J; Laboratory of Immunology -INSERM U475, Saint-Eloi Hospital,; Montpellier, France.
- In rheumatoid arthritis (RA), T cells have been proposed either as a main actor or as an epiphenomenon in such a primarily synoviocyte-driven disease. A major issue remains the remarkable paradox between the T cell infiltrate and the relative failure to detect definite markers of their activity. To determine the Th1/T
- Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-type bias in normal pregnancy and pregnancy failure.
- Am J Reprod Immunol. 1999 Nov;42(5):273-81. Unique Identifier : AIDSLINE MED/20049676
- Makhseed M; Raghupathy R; Azizieh F; Al-Azemi MM; Hassan NA; Bandar A; Department of Obstetrics and Gynecology, Faculty of Medicine,; Kuwait University. abrar@hsc.kuniv.edu.kw
- PROBLEM: Profiles of Th1- and Th2-type cytokines were studied in women with a history of successful pregnancy and in women with a history of unexplained recurrent spontaneous abortions (RSA) with the objective of elucidating Th1- and Th2-type bias in normal pregnancy and pregnancy failure. METHOD OF STUDY: Peripheral
- Inhibitor of HIV-1 reverse transcriptase: N'-(5-bromo-2-pyridyl)-N-[2-(2,5-dimethoxyphenyl)ethyl]thiourea.
- Acta Crystallogr C. 1999 Dec 15;55 ( Pt 12):2122-4. Unique Identifier : AIDSLINE MED/20106037
- Sudbeck EA; Jennissen JD; Venkatachalam TK; Uckun FM; Department of Structural Biology, Hughes Institute, St Paul, MN; 55113, USA. esudbeck@ih.org
- The crystal structure of the title compound, C16H18Br-N3O2S (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase, revealed an intramolecular hydrogen bond between a thiourea N atom and the pyridyl-N atom [N-H...N = 2.671 (3) A, graph-set motif S1(1)(6)] that imparts a more rigid conformation to t
- Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: biological correlates of clinical outcome.
- Eur J Cancer. 1999 Dec;35(13):1809-15. Unique Identifier : AIDSLINE MED/20138951
- Cattelan AM; Calabro ML; Aversa SM; Zanchetta M; Meneghetti F; De Rossi A; Chieco-Bianchi L; Department of Infectious Diseases, General Hospital of Padova,; Italy.
- The clinical response of AIDS-related Kaposi s sarcoma (KS) to highly active antiretroviral therapy (HAART), a combination of human immunodeficiency virus type 1 (HIV-1) protease and reverse transcriptase inhibitors, was studied in 11 patients, all but one with progressive KS. CD4+ cell counts, plasma HIV-1 RNA levels
- Detection of antibodies to human herpesvirus 8 in Italian children: evidence for horizontal transmission.
- Br J Cancer. 2000 Feb;82(3):702-4. Unique Identifier : AIDSLINE MED/20144890
- Whitby D; Luppi M; Sabin C; Barozzi P; Di Biase AR; Balli F; Cucci F; Weiss RA; Boshoff C; Torelli G; Institute of Cancer Research, London, UK.
- Human herpesvirus 8 (HHV-8), also known as Kaposi s sarcoma associated herpesvirus (KSHV), has been shown to be the causative agent for Kaposi s sarcoma (KS) and to be more prevalent in populations or risk groups at increased risk for KS. HHV-8 infection is rare in children from the US and the UK, but has been reporte
- Human herpesvirus type 8 and epstein-barr virus-associated cutaneous lymphoma taking anaplastic large cell morphology in a man with HIV infection.
- Br J Dermatol. 1999 Jul;141(1):141-5. Unique Identifier : AIDSLINE MED/99348108
- Nakamura K; Katano H; Hoshino Y; Nakamura T; Hosono O; Masunaga A; Mori S; Iwamoto A; Tamaki K; Department of Dermatology, University of Tokyo, 7-3-1 Hongo,; Bunkyo-ku, Tokyo 113-0033, Japan. makamura-der@h.u-tokyo.ac.jp
- Human herpesvirus type 8 (HHV-8, Kaposi s sarcoma-associated herpesvirus)-positive lymphoma taking anaplastic large cell morphology in the skin is described in a 46-year-old man with AIDS. Multiple erythematous nodules appeared on the trunk and extremities during the treatment of AIDS. Histological examination of cuta
- Absence of a link between human herpesvirus 8 and pemphigus [letter]
- Br J Dermatol. 1999 Jul;141(1):159-60. Unique Identifier : AIDSLINE MED/99348114
- Dupin N; Marcelin AG; Calvez V; Andr C
- Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment.
- Unique Identifier : AIDSLINE MED/99348086
- Fearfield LA; Rowe A; Francis N; Bunker CB; Staughton RC
- The predominant itchy folliculitis associated with human immunodeficiency virus (HIV) infection appears to be an
- Evidence for the cofactor role of human T-cell lymphotropic virus type 1 in mycosis fungoides and Sezary syndrome.
- Br J Dermatol. 1999 Jul;141(1):44-9. Unique Identifier : AIDSLINE MED/99348091
- Shohat M; Hodak E; Hannig H; Bodemer W; David M; Shohat B; Department of Dermatology and Cellular Immunology Unit, Rabin; Medical Center, Petah Tiqva 49100, Israel and Deutsches; Primatenzentrum, Gottingen, Germany.
- The aetiology of mycosis fungoides (MF) and Sezary syndrome (SS) is unknown. A pathogenic role for the human T-cell lymphotropic virus type 1 (HTLV-1) has been suggested but remains controversial. We used an animal model to test the possibility that peripheral blood mononuclear cells (PBMC) obtained from MF patients h
- No evidence for a role of human herpesvirus type 8 in sarcoidosis: molecular and serological analysis.
- Br J Dermatol. 1999 Sep;141(3):492-6. Unique Identifier : AIDSLINE MED/20050136
- Lebbe C; Agbalika F; Flageul B; Pellet C; Rybojad M; Cordoliani F; Farge D; Vignon-Pennamen MD; Sheldon J; Morel P; Calvo F; Schulz TF; Department of Dermatology, Hopital Saint-Louis, Paris, France.
- The aim of this study was to analyse the association between human herpesvirus type 8 (HHV8) and sarcoidosis. Using nested polymerase chain reaction (PCR), we tested the presence of HHV8 DNA sequences in 13 skin specimens and peripheral blood mononuclear cells from eight patients suffering from sarcoidosis. We also lo
- Pneumocystis carinii pneumonia in patients receiving immunosuppressive drugs for dermatological diseases.
- Br J Dermatol. 1999 Sep;141(3):528-30. Unique Identifier : AIDSLINE MED/20050144
- Raychaudhuri SP; Siu S; Department of Medicine, Kaiser Permanente, Oakland, CA, USA.
- In recent years, Pneumocystis carinii pneumonia (PCP) has been increasingly reported in patients without human immunodeficiency virus (HIV) infection. The increased occurrence of PCP in non-HIV-immunocompromised subjects has been attributed to several factors: use of stronger immunosuppressive regimens, higher awarene
- Micrococcus folliculitis in HIV-1 disease.
- Br J Dermatol. 1999 Sep;141(3):558-61. Unique Identifier : AIDSLINE MED/20050152
- Smith KJ; Neafie R; Yeager J; Skelton HG; Departments of Dermatology and Pathology, National Naval Medical; Center, 8901 Wisconsin Avenue, Bethesda, MD 20889-5600, USA.; HSkelIII@aol.com
- Organisms with little pathogenic potential in immunocompetent hosts may produce disease in HIV-1 + patients. We describe three HIV-1 + patients in late disease who presented with pruritic papules with central ulceration over the face and arms. In all the patients the eruptions had been present for months, and the pati
- Evaluation of a drama-in-education programme to increase AIDS awareness in South African high schools: a randomized community intervention trial.
- Int J STD AIDS. 2000 Feb;11(2):105-11. Unique Identifier : AIDSLINE MED/20141946
- Harvey B; Stuart J; Swan T; AIDS Programme, KwaZulu Department of Health, South Africa.
- A community intervention trial was undertaken in KwaZulu Natal, South Africa to evaluate the effectiveness of a high school drama-in-education programme. Seven pairs of secondary schools were randomized to receive either written information about HIV/AIDS or the drama programme. Q
- Risk perception and counselling among HIV-positive women in Sao Paulo, Brazil.
- Int J STD AIDS. 2000 Feb;11(2):112-4. Unique Identifier : AIDSLINE MED/20141947
- Ventura-Filipe EM; Bugamelli LE; Leme B; Santos NJ; Garcia S; Paiva V; Hearst N; Programa Estadual de DST/AIDS de Sao Paulo (Sao Paulo State; STD/AIDS Programme), Brazil. efilipe@cebinet.com.br
- This study of HIV-positive women at a clinic for HIV/AIDS in Sao Paulo examined their risk perception for HIV before they had learned of their diagnosis and their experiences with pre- and post-test counselling. A sample of 148 women was interviewed regarding demographics, HIV risk factors and risk perception, pre- an
- Trend of antimicrobial resistance in Neisseria gonorrhoeae at New Delhi, India.
- Int J STD AIDS. 2000 Feb;11(2):115-8. Unique Identifier : AIDSLINE MED/20141948
- Ray K; Bala M; Kumar J; Misra RS; Regional STD Teaching, Training and Research Centre, Safdarjung; Hospital, New Delhi, India.
- We aim to monitor the trends of antimicrobial resistance in Neisseria gonorrhoeae and to compare the results of antimicrobial sensitivity by disc diffusion and minimum inhibitory concentration (MIC). Two hundred and eleven confirmed strains of N. gonorrhoeae were subjected to antimicrobial sensitivity testing by disc
- Lymphocytic interstitial pneumonitis in an HIV-infected adult: response to antiretroviral therapy.
- Int J STD AIDS. 2000 Feb;11(2):119-22. Unique Identifier : AIDSLINE MED/20141949
- Scarborough M; Lishman S; Shaw P; Fakoya A; Miller RF; HIV/AIDS Unit, UCL Hospitals Trust, London, UK.
- An annular erythema secondary to primary genital herpes.
- Int J STD AIDS. 2000 Feb;11(2):123-5. Unique Identifier : AIDSLINE MED/20141950
- Mahto M; Mandal D; Beck MH; Wells S; Bolton Centre for Sexual Health, Royal Bolton Hospital,; Farnworth, UK.
- Disseminated Penicillium marneffei in a patient infected with human immunodeficiency virus.
- Int J STD AIDS. 2000 Feb;11(2):126-8. Unique Identifier : AIDSLINE MED/20141951
- Vilar FJ; Hunt R; Wilkins EG; Wilson G; Jones NP; Department of Infectious Diseases and Tropical Medicine, North; Manchester General Hospital, UK.
- A case of a 31-year-old man with systemic Penicillium marneffei infection acquired in Thailand and who developed endophthalmitis is described. This presentation has not previously been reported. He responded to combined treatment with intravenous and intravitreal amphotericin.
- Sexual health knowledge of adolescents in a Great Yarmouth high school [letter]
- Int J STD AIDS. 2000 Feb;11(2):129-31. Unique Identifier : AIDSLINE MED/20141952
- Harry TC
- The need to exercise caution in the management of patients co-infected with HIV and hepatitis B [letter]
- Int J STD AIDS. 2000 Feb;11(2):131-2. Unique Identifier : AIDSLINE MED/20141953
- Joseph AT; Chandramani S; Cox M
- Four-drug salvage antiretroviral treatment including nelfinavir and efavirenz in highly treated children with congenital HIV disease [letter]
- Int J STD AIDS. 2000 Feb;11(2):132-3. Unique Identifier : AIDSLINE MED/20141954
- Manfredi R; Chiodo F
- Behavioural and biomedical risk factors for the transmission of HIV/AIDS in Bangladesh [letter]
- Int J STD AIDS. 2000 Feb;11(2):133-4. Unique Identifier : AIDSLINE MED/20141955
- Shah SA; Kristensen S; Khan OA
- The emerging AIDS crisis in Russia: review of enabling factors and prevention needs.
- Int J STD AIDS. 2000 Feb;11(2):71-5. Unique Identifier : AIDSLINE MED/20141940
- Kalichman SC; Kelly JA; Sikkema KJ; Koslov AP; Shaboltas A; Granskaya J; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Department of Psychiatry and Behavioral Medicine,; 53226, USA. sethk@mcw.edu
- Eastern Europe is experiencing increased rates of HIV/AIDS, and the Russian Federation is among the countries with the most alarming case rate increases. Behavioural and biological studies demonstrate that the transmission of HIV in Russia is occurring as a result of injection drug use, homosexual, and heterosexual ri
- Mycoplasma species in rapid and slow HIV progressors.
- Int J STD AIDS. 2000 Feb;11(2):76-9. Unique Identifier : AIDSLINE MED/20141941
- Ainsworth JG; Hourshid S; Easterbrook PJ; Gilroy CB; Weber JN; Taylor-obinson D; Division of Medicine, Imperial College School of Medicine, St; Mary's Hospital, London, UK.
- We determined the relationship between the presence of Mycoplasma fermentans and Mycoplasma penetrans and the rate of progression of HIV-associated disease in a nested case-control study based on a cohort of 159 HIV-infected patients with different rates of disease progression. Study participants were divided into 3 p
- Asymptomatic penile HPV infection: a prospective study.
- Int J STD AIDS. 2000 Feb;11(2):80-4. Unique Identifier : AIDSLINE MED/20141942
- Wikstrom A; Popescu C; Forslund O; Department of Dermatovenereology, Karolinska Hospital, Stockholm,; Sweden.
- The occurrence of human papillomavirus (HPV) among males was analysed with the polymerase chain reaction (PCR) method. Penile brush samples were taken once from 147 males attending for a control or for HPV non-related reasons, and consecutive samples were collected from 88 males re-attending the clinic. Of the males a
- Detection of human cytomegalovirus retinitis and monitoring of ganciclovir treatment using conjunctival swab with polymerase chain reaction in AIDS patients.
- Int J STD AIDS. 2000 Feb;11(2):85-91. Unique Identifier : AIDSLINE MED/20141943
- Chiou SH; Liu JH; Wong WW; Chan YJ; Chang YC; Wang JJ; Liu CY; Liu WT; Chen SC; Hsu WM; Department of Ophthalmology, Veterans General Hospital, Taipei,; Taiwan, Republic of China.
- This report studies the accuracy of conjunctival swab polymerase chain reaction (CS-PCR) for the diagnosis of human cytomegalovirus retinitis (HCMV) in AIDS patients. PCR and virus culture were used for the detection of HCMV in conjunctival swab, serum, and urine specimens from 38
- A survey of patients with Chlamydia trachomatis infection: sexual behaviour and perceptions about contact tracing.
- Int J STD AIDS. 2000 Feb;11(2):92-5. Unique Identifier : AIDSLINE MED/20141944
- Tyden T; Ramstedt K; Department of Public Health and Caring Sciences, University of; Uppsala, Sweden. tanja.tyden@vard.uu.se
- The aim of this study was to evaluate how patients with Chlamydia trachomatis infection perceived the legal enforcement of partner notification and to seek their views on legislation impinging on their own sexual behaviour. The investigation was performed at STD clinics in Stockholm, S
- Condom use and 'withdrawal': exploring gay men's practice of anal intercourse.
- Int J STD AIDS. 2000 Feb;11(2):96-104. Unique Identifier : AIDSLINE MED/20141945
- Richters J; Knox S; Crawford J; Kippax S; National Centre in HIV Social Research, University of New South; Wales, Sydney, Australia. j.richters@unsw.edu.au
- Some gay men who have unprotected anal intercourse avoid ejaculation-they practise withdrawal . Using data collected in 1997 from a sample of Sydney gay men (n=625), we explored the relation between men s practice of ejaculation and their use of condoms. We also investigated whether men who had unprotected withdrawal
- [Prevention of transmissible diseases. Work Group for Transmissible Diseases of the PAPPS]
- Aten Primaria. 1999 Dec;24 Suppl 1:99-117. Unique Identifier : AIDSLINE MED/20131580
- Pareja Bezares A; Alvarez Pasquin MJ; Batalla Martinez C; Comin Bertran E; Gomez Marco JJ; Nino Martin V; Pineiro Guerrero R
- Human obesity and thinness, hyperlipidemia, hyperglycemia, and insulin resistance associated with HIV1 protease inhibitors. Prevention by alternating several antiproteases in short sequences [editorial]
- Biomed Pharmacother. 1999 Dec;53(10):449-51. Unique Identifier : AIDSLINE MED/20128721
- Mathe G
- In 1997, and mainly in 1998 and 1999, a lipodystrophic syndrome with central obesity, peripheral fat loss, hyperlipidemia, hyperglycemia and insulin-resistant-diabetes II, was described as the most frequent manifestation of toxicity of HIV1 virostatic therapy, associated with
- In-vivo delivery of therapeutic proteins by genetically-modified cells: comparison of organoids and human serum albumin alginate-coated beads.
- Biomed Pharmacother. 1999 Dec;53(10):471-83. Unique Identifier : AIDSLINE MED/20128726
- Shinya E; Dervillez X; Edwards-Levy F; Duret V; Brisson E; Ylisastigui L; Levy MC; Cohen JH; Klatzmann D; Laboratoire de biologie et therapeutique des pathologies; immunitaires, UPMC/CNRS ESA 7087, Hopital de la; Pitie-Salpetriere, Paris, France.
- We have designed a self-assembling multimeric soluble CD4 molecule by inserting the C-terminal fragment of the alpha chain of human C4-binding protein (C4bp alpha) at the C-terminal end of human soluble CD4 genes. This CD4-C4bp alpha fusion protein (sMulti-CD4) and two other reference molecules, a fusion protein of hu
- Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment? A ten-year experiment must liberate them [editorial]
- Biomed Pharmacother. 1999 Dec;53(10):484-6. Unique Identifier : AIDSLINE MED/20128727
- Mathe G
- We detected in 1989, with the inhibitor test of proviral insertion into c-erb B erythroblastosis, two retrovirus integrase inhibitors: hydroxy-methyl-ellipticine and acriflavine. They have been used for ten years in AIDS patients with high efficacy and no toxicity. Since vitamin B12 and cobalt, which it contains, have
- Functional status of the immune system after chronic administration of 2'-deoxycoformycin in the BB rat.
- Unique Identifier : AIDSLINE MED/20133370
- Thliveris JA; HayGlass KT; Manchur D; Rector E; Begleiter A; Johnston JB; Department of Human Anatomy and Cell Science, University of; Manitoba, Winnipeg, Canada. thliver@ms.umanitoba.ca
- Insulin-dependent diabetes mellitus (IDDM) is caused by autoimmune destruction of pancreatic beta cells with the primary mechanism being cell mediated. The BB rat develops insulitis and IDDM with many features analogous to the disease in man. In previous studies we reported that weekly administration of 2 -deoxycoform
- [Regression of cytomegalovirus retinitis in AIDS patients without systemic maintenance anti-cytomegalovirus therapy treated with highly active antiretroviral therapy]
- Ophthalmologe. 1999 Dec;96(12):829-31. Unique Identifier : AIDSLINE MED/20107930
- Schaller UC; Walli RK; Mueller AJ; Klauss V; Universitats-Augenklinik Munchen.
- BACKGROUND: The purpose of this study was to evaluate the course of CMV retinitis after initiation of highly active antiretroviral therapy (HAART) and discontinuation of systemic anti-CMV maintenance therapy. PATIENTS AND METHODS: Case reports are presented for
- HIV infection of megakaryocytic cell lines.
- Leuk Lymphoma. 2000 Jan;36(3-4):397-404. Unique Identifier : AIDSLINE MED/20137377
- Sato T; Sekine H; Kakuda H; Miura N; Sunohara M; Fuse A; Department of Pediatrics, School of Medicine, Chiba University,; Japan.
- Thrombocytopenia is a common hematologic disorder in HIV infection and occurs in both asymptomatic and AIDS patients. An autoimmune mechanism has been postulated for the platelet destruction associated with some forms of thrombocytopenia. However, recent studies revealed that megakaryocytes are susceptible to HIV infe
- In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain.
- Neurochem Int. 2000 Mar;36(3):185-91. Unique Identifier : AIDSLINE MED/20140021
- Pocernich CB; La Fontaine M; Butterfield DA; Department of Chemistry, University of Kentucky, Lexington 40506,; USA.
- Glutathione deficiency has been associated with a number of neurodegenerative diseases including Lou Gehrig s disease, Parkinson s disease, and HIV. A crucial role for glutathione is as a free radical scavenger. Alzheimer s disease (AD) brain is characterized by oxidative stress, manifested by protein oxidation, lipid
- Protists as opportunistic pathogens: public health impact in the 1990s and beyond.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):15-20. Unique Identifier : AIDSLINE MED/20114712
- Kaplan JE; Jones JL; Dykewicz CA; Division of AIDS, STD and TB Laboratory Research, National Center; for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA. jxk2@cdc.gov
- Protist organisms (protozoa and fungi) have become increasingly prominent as opportunistic pathogens among persons infected with human immunodeficiency virus (HIV) and among organ transplant recipients--two immunocompromised populations that have increased dramatically in the past two decades. Pneumocystis carinii pne
- Clinical presentation and significance of emerging opportunistic infections.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):21-3. Unique Identifier : AIDSLINE MED/20114713
- Miller RF; Windeyer Institute of Medical Sciences, Royal Free and University; College Medical School, London, UK. rmiller@gum.ucl.ac.uk
- In recent years the clinical face of the Acquired Immune Deficiency Syndrome has changed significantly as a consequence of use of prophylaxis against Pneumocystis carinii pneumonia and combination antiretroviral therapy. In this context several opportunistic pathogens have emerged as causes of clinically important dis
- Penicillium marneffei: an insurgent species among the penicillia.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):24-8. Unique Identifier : AIDSLINE MED/20114714
- Cooper CR Jr; Haycocks NG; WHO Collaborating Center for Tropical Diseases, Department of; Pathology, University of Texas Medical Branch, Galveston; 77555-0609, USA. crcooper@utmb.edu
- Most species of Penicillium are considered relatively benign with respect to causing human disease. However, one species, P. marneffei, has emerged as a significant pathogen particularly among individuals who live in Southeast Asia and are concurrently infected with the human immunodeficiency virus. While environmenta
- The increasing importance of Acanthamoeba infections.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):29-36. Unique Identifier : AIDSLINE MED/20114715
- Marciano-Cabral F; Puffenbarger R; Cabral GA; Department of Microbiology & Immunology, Medical College of; Virginia of Virginia Commonwealth University, Richmond; 23298-0678, USA. ))). fmcabral@hsc.vcu.edu
- Free-living amebae belonging to the genus Acanthamoeba are the causative agents of granulomatous amebic encephalitis, a chronic progressive disease of the central nervous system, and of amebic keratitis, a chronic eye infection. Granulomatous amebic encephalitis occurs more frequently in immunocompromised patients whi
- Leishmania, Trypanosoma and monoxenous trypanosomatids as emerging opportunistic agents.
- J Eukaryot Microbiol. 2000 Jan-Feb;47(1):37-9. Unique Identifier : AIDSLINE MED/20114716
- Dedet JP; Pratlong F; Laboratoire de Parasitologie, C.H.U. de Montpellier, 163, France.; parasito@sc.univ-montp1.fr
- Immunosuppression is associated with the occurrence of a large variety of infections, several of them due to opportunistic protozoa. The parasitic protozoa of the family Trypanosomatidae vary greatly in their importance as potential opportunistic pathogens. African trypanosomiasis is no more common nor severe during A
- The sensitivity and specificity of self-reported symptoms in individuals with traumatic brain injury.
- Brain Inj. 2000 Jan;14(1):21-33. Unique Identifier : AIDSLINE MED/20134119
- Gordon WA; Haddad L; Brown M; Hibbard MR; Sliwinski M; Department of Rehabilitation Medicine, Mount Sinai School of; Medicine, New York, NY 10029, USA. Wayne_Gordon@mssm.edu
- In this study, self-reported symptoms (cognitive, physical, behavioural/affective) from the TIRR Symptom Checklist are compared across six panels: 135 individuals with mild TBI, 275 with moderate/severe TBI, 287 with no disability, 104 with spinal cord injury, 197 who are HIV positive and 107 who had undergone liver t
- The unveiling of traumatic brain injury in an HIV/AIDS population.
- Brain Inj. 2000 Jan;14(1):35-44. Unique Identifier : AIDSLINE MED/20134120
- Jaffe MP; O'Neill J; Vandergoot D; Gordon WA; Small B; Center for Essential Management Services, NY, USA.
- This study examines the frequency of traumatic brain injury (TBI) in an HIV/AIDS population and its associated symptomatology. A panel of 173 individuals with HIV were split into two groups--those who have experienced a blow to the head within their lifetime (n = 128) and those who have not (n = 45). Self-reported sym
- [Drug-induced urinary calculi in 1999]
- Prog Urol. 1999 Dec;9(6):1023-33. Unique Identifier : AIDSLINE MED/20122707
- Daudon M; Laboratoire de Biochimie A, Hopital Necker-Enfants Malades,; Paris, France.
- Drug-induced urolithiasis are observed in 1.6% of the urinary calculi in France . Drugs crystals are identified in two thirds of these stones. Other drugs are responsible for stones which have an apparent metabolic origin (one third of the cases). Stone analysis using physical metho
- One-step capillary isoelectric focusing for the separation of the recombinant human immunodeficiency virus envelope glycoprotein glycoforms.
- J Chromatogr A. 2000 Jan 7;866(1):121-35. Unique Identifier : AIDSLINE MED/20143250
- Tran NT; Taverna M; Chevalier M; Ferrier D; Laboratoire de Chimie Analytique, Faculte de Pharmacie,; Chatenay-Malabry, France.
- One-step capillary isoelectric focusing was investigated as a rapid method to resolve the glycoforms of the heterogeneous recombinant human immunodeficiency virus (HIV) envelope glycoprotein (rgp 160sMN/LAI). The separation was performed in a poly(vinyl alcohol) (PVA) coated capillary using a mixture of ampholyte of n
- In vitro ethanol suppresses alveolar macrophage TNF-alpha during simian immunodeficiency virus infection.
- Am J Respir Crit Care Med. 2000 Jan;161(1):135-40. Unique Identifier : AIDSLINE MED/20087336
- Stoltz DA; Nelson S; Kolls JK; Zhang P; Bohm RP Jr; Murphey-Corb M; Bagby GJ; Department of Medicine, Section of Pulmonary/Critical Care,; Alcohol Research Center, New Orleans, Louisiana, USA.
- Pulmonary infections are a significant cause of morbidity and mortality in patients with alcohol abuse and human immunodeficiency virus (HIV) infection, two immunocompromising conditions that frequently coexist. This study examined the separate and combined effects of in vivo lentiviral infection and in vitro alcohol
- Reversal of human immunodeficiency virus type 1 protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):101-5. Unique Identifier : AIDSLINE MED/20087391
- Nair MP; Schwartz SA; Department of Medicine and Microbiology, Division of Allergy,; Immunology and Rheumatology, and Buffalo General Hospital, School; of Medicine and Biomedical Sciences, State University of New York; at Buffalo, New York 14203, USA. mnair@acsu.buffalo.edu
- A recombinant fusion peptide, Env-Gag, derived from the human immunodeficiency virus type 1 (HIV-1) genome corresponding to a defined portion of the envelope (Env) and internal core (Gag) proteins was examined for immunoregulatory effects on the cytotoxic activity of natural killer (NK) cell-enriched, large granular l
- Evaluation of the quantiplex human immunodeficiency virus type 1 RNA 3.0 assay in a tertiary-care center.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):122-4. Unique Identifier : AIDSLINE MED/20087396
- Gale H; Infectious Diseases Section, Medical Service, Veterans Affairs; Medical Center, Washington, D.C 20422, USA.; gale.howard@washington.va.gov
- The Quantiplex human immunodeficiency virus type 1 RNA 3.0 Assay (bDNA) (Bayer Diagnostics, Walpole, Mass.) produced linear and reproducible (intra-assay and interassay) results over its quantification range of 50 to 500,000 copies/ml of plasma with 96% specificity. A threefold or 0.5-log(10) change or greater was cli
- Development of positive selectable markers for the fungal pathogen Cryptococcus neoformans.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):125-8. Unique Identifier : AIDSLINE MED/20087397
- Hua J; Meyer JD; Lodge JK; Edward A. Doisy Department of Biochemistry and Molecular Biology,; St. Louis University School of Medicine, St. Louis, Missouri; 63104, USA.
- Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningitis in approximately 10% of patients with AIDS. New selectable markers which confer resistance to G418 or phleomycin when transformed into C. neoformans were made. A hygromycin-selectable marker was modified to allow selection with a single
- Diagnosis of human immunodeficiency virus infection using an immunoglobulin E-based assay.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):55-7. Unique Identifier : AIDSLINE MED/20087382
- Fletcher M; Miguez-Burbano MJ; Shor-Posner G; Lopez V; Lai H; Baum MK; Department of Medicine, University of Miami School of Medicine,; Miami, Florida.
- Immunoglobulin assays that are sensitive and specific for detecting human immunodeficiency virus type 1 (HIV-1) infection are especially important in developing countries where PCR and viral culture may not be readily available. Immunoglobulin E (IgE), which is elevated in HIV-1 infection, is the only antibody that do
- Validation of immune-complex enzyme immunoassays for diagnosis of pneumococcal pneumonia among adults in Kenya.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):64-7. Unique Identifier : AIDSLINE MED/20087384
- Scott JA; Hall AJ; Leinonen M; Centre for Geographic Medicine Research-Coast, Kenya Medical; Research Institute, Kilifi, Kenya. Ascott@kilifi.mimcom.net
- The efficacy of pneumococcal vaccines in protecting against pneumococcal pneumonia can feasibly be measured only with a diagnostic technique that has a high specificity (0.98 to 1.00) and a sensitivity greatly exceeding that of blood cultures (>0.2 to 0.3). In this context immune-complex enzyme immunoassays (EIAs) off
- Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.
- Clin Diagn Lab Immunol. 2000 Jan;7(1):96-100. Unique Identifier : AIDSLINE MED/20087390
- Nair MP; Chadha KC; Hewitt RG; Mahajan S; Sweet A; Schwartz SA; State University of New York at Buffalo, Buffalo General; Hospital, Buffalo, New York 14203, USA. mnair@acsu.buffalo.edu
- Earlier studies have supported a significant role for cocaine in the susceptibility to and the progression of human immunodeficiency virus type 1 (HIV-1) infection. Recently, several unique HIV-1 entry coreceptors (e.g., CCR5 and CCR3) and a trio of HIV-1-specific suppressor chemokines, namely, RANTES (regulated-upon-
- Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.
- Immunity. 2000 Jan;12(1):27-37. Unique Identifier : AIDSLINE MED/20125019
- Ouyang W; Lohning M; Gao Z; Assenmacher M; Ranganath S; Radbruch A; Murphy KM; Department of Pathology and Center for Immunology, Howard Hughes; Medical Institute, Washington University School of Medicine, St.; Louis, Missouri 63110, USA.
- The initial source of IL-4-inducing Th2 development and the mechanism of stable Th2 commitment remain obscure. We found the reduced level of IL-4 production in Stat6-deficient T cells to be significantly higher than in Th1 controls. Using a novel cell surface affinity matrix technique, we found that IL-4-secreting Sta
- Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
- Immunity. 2000 Jan;12(1):61-70. Unique Identifier : AIDSLINE MED/20125022
- Kanazawa S; Okamoto T; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine,; University of California, San Francisco 94143, USA.
- AIDS and the bare lymphocyte syndrome (BLS) are severe combined immunodeficiencies. BLS results from mutations in genes that regulate the expression of class II major histocompatibility (MHC II) determinants. One of these is the class II transactivator (CIITA). HIV and its transcriptional transactivator (Tat) also blo
- Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.
- Immunity. 2000 Jan;12(1):83-93. Unique Identifier : AIDSLINE MED/20125024
- Chen W; Anton LC; Bennink JR; Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892-0440, USA.
- Following influenza virus infection, the numbers of mouse TCD8+ cells responding to five different determinants vary more than 50-fold in primary responses but less so in secondary responses. Surprisingly, each determinant elicits a highly diverse and highly sensitive TCD8+ response. Inefficient antigen processing by
- Immunogene therapy against mouse leukemia using B7 molecules.
- Cancer Gene Ther. 2000 Jan;7(1):144-50. Unique Identifier : AIDSLINE MED/20141835
- Takahashi T; Hirano N; Takahashi T; Chiba S; Yazaki Y; Hirai H; Third Department of Internal Medicine, Faculty of Medicine,; University of Tokyo, Japan.
- B7 costimulatory molecules play an important role in T-cell activation. It is well known that tumor cells that express B7 molecules can elicit antitumor immunity, but little is known regarding which B7 molecule, B7-1 (CD80) or B7-2 (CD86), can do so more efficiently. To address this issue, we have introduced B7-1 or B
- CXC and CC chemokine receptors on coronary and brain endothelia.
- Mol Med. 1999 Dec;5(12):795-805. Unique Identifier : AIDSLINE MED/20133089
- Berger O; Gan X; Gujuluva C; Burns AR; Sulur G; Stins M; Way D; Witte M; Weinand M; Said J; Kim KS; Taub D; Graves MC; Fiala M; Department of Neurology, UCLA School of Medicine, Los Angeles,; California 90095-1769, USA.
- BACKGROUND: Chemokine receptors on leukocytes play a key role in inflammation and HIV-1 infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue invasion and angiogenesis. MATERIALS AND METHODS: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC)
- Critical role of nitric oxide during the apoptosis of peripheral blood leukocytes from patients with AIDS.
- Unique Identifier : AIDSLINE MED/20133091
- Mossalayi MD; Becherel PA; Debre P
- BACKGROUND: Highly active antiretroviral therapies (HAART) increase the CD4(+) cell count, but complete normalization of this parameter has not been obtained in some patients. As oxidative stress plays an important role during human immunodeficiency virus type 1 (HIV-1)-associated deme
- Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome.
- RNA. 2000 Jan;6(1):96-102. Unique Identifier : AIDSLINE MED/20132236
- Takahashi KI; Baba S; Chattopadhyay P; Koyanagi Y; Yamamoto N; Takaku H; Kawai G; Department of Industrial Chemistry, Chiba Institute of; Technology, Japan.
- Generation of RNA dimeric form of the human immunodeficiency virus type 1 (HIV-1) genome is crucial for viral replication. The dimerization initiation site (DIS) has been identified as a primary sequence that can form a stem-loop structure with a self-complementary sequence in the loop and a bulge in the stem. It has
- Avascular necrosis of bone in human immunodeficiency virus infected patients.
- Clin Imaging. 1999 Sep-Oct;23(5):314-8. Unique Identifier : AIDSLINE MED/20128735
- Blacksin MF; Kloser PC; Simon J; Department of Radiology, University of Medicine & Dentistry of; New Jersey, C-320 University Hospital, Newark 07103-2426, USA.
- The objective of this article was to delineate the causes of avascular necrosis (AVN) in patients with human immunodeficiency virus (HIV). HIV-infected patients with pain in large joints were prospectively screened. Patients had radiographs and magnetic resonance imaging of their affected joints. Serum lipids, anticar
- A patient with an acute viral syndrome.
- Tenn Med. 2000 Feb;93(2):64-5. Unique Identifier : AIDSLINE MED/20133550
- Aronoff DM; Morgan HJ; Vanderbilt University Medical Center, Nashville, USA.
- CPHA and the global effort to strengthen responses to HIV/AIDS [news]
- Can J Public Health. 1999 Nov-Dec;90(6):364. Unique Identifier : AIDSLINE MED/20144507
- Dafoe GH
- Fas-resistance in ATL cell lines not associated with HTLV-I or FAP-1 production.
- Cancer Lett. 1999 Dec 1;147(1-2):215-9. Unique Identifier : AIDSLINE MED/20123505
- Yamada Y; Sugahara K; Tsuruda K; Nohda K; Hata T; Maeda T; Honda M; Tawara M; Hayashibara T; Joh T; Tomonaga M; Miyazaki Y; Kamihira S; Department of Laboratory Medicine, Nagasaki University School of; Medicine, Japan.
- A preventive role for human T-cell leukemia virus type-I (HTLV-I) and Fas-associated phosphatase-1 (FAP-1) in Fas-mediated apoptosis has been reported in HTLV-I-infected cells. In the present study, we examined whether these molecules increased during the acquisition of Fas-resistance in adult T-cell leukemia (ATL) ce
- Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo.
- Cancer Res. 2000 Jan 15;60(2):253-8. Unique Identifier : AIDSLINE MED/20129032
- Bronte V; Apolloni E; Ronca R; Zamboni P; Overwijk WW; Surman DR; Restifo NP; Zanovello P; Department of Oncology and Surgical Sciences, University of; Padova, Italy. vbronte@ux1.unipd.it
- Self melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet
- Cytokine replacement in patients with HIV-1 non-Hodgkin's lymphoma: the rationale for low-dose interleukin-2 therapy.
- Cancer J Sci Am. 2000 Feb;6 Suppl 1:S45-51. Unique Identifier : AIDSLINE MED/20148094
- Shah MH; Baiocchi RA; Fehniger TA; Khatri VP; Gould M; Poiesz B; Bernstein ZP; Caligiuri MA; Division of Hematology/Oncology, The Arthur G. James Cancer; Hospital and Solove Research Institute, Columbus, Ohio, USA.
- PURPOSE: The drastic increase in the incidence of non-Hodgkin s lymphoma in patients infected with HIV-1 is testimony to the fact that our immune system is critical for the prevention of certain malignancies. Preclinical and clinical studies were conducted to (1) gain further insig
- The future of interleukin-2: enhancing therapeutic anticancer vaccines.
- Cancer J Sci Am. 2000 Feb;6 Suppl 1:S76-80. Unique Identifier : AIDSLINE MED/20148100
- Overwijk WW; Theoret MR; Restifo NP; Surgery Branch, National Cancer Institute, National Institutes of; Health, Bethesda, Maryland 20892-1502, USA.
- PURPOSE: The purpose of our efforts is to trigger the immune destruction of established cancer. Interleukin (IL)-2 can mediate the regression of tumors in patients with melanoma and renal cell carcinoma. In animal models, the antitumor effects of IL-2 are mediated by T
- [Use of plasmapheresis in patients with AIDS and peripheral polyneuropathy]
- Pol Merkuriusz Lek. 1999 Nov;7(41):215-7. Unique Identifier : AIDSLINE MED/20144705
- Lapinski TW; Prokopowicz D; Kliniki Obserwacyjno- Zakaznej Akademii Medycznej w Bialymstoku.
- The plasmapheresis is procedure removal of plasma and simultaneously, together with plasma, toxins, incorrect metabolites, antigens and immunological complexes. In patients with HIV infection often appearance periphery polyneuropathy. This is connected with autoantibody action on the damage of neurone. The aim of this
- The art of molecular graphics. The 1998 Molecular Graphics Art Show.
- J Mol Graph Model. 1999 Feb;17(1):55-6. Unique Identifier : AIDSLINE MED/20126747
- Goodsell DS; Scripps Research Institute, Department of Molecular Biology, La; Jolla, CA 92037, USA. goodsell@scripps.edu
- HIV testing of patients: let's waive the waiver.
- CMAJ. 2000 Jan 25;162(2):210-1. Unique Identifier : AIDSLINE MED/20139011
- Tyndall MW; Schechter MT; Department of Health Care and Epidemiology, Faculty of Medicine,; University of British Columbia, Vancouver.; martin.schechter@ubc.ca
- Determination of nelfinavir, a potent HIV protease inhibitor, and its active metabolite M8 in human plasma by high-performance liquid chromatography with photodiode-array detection.
- J Chromatogr B Biomed Sci Appl. 1999 Dec 10;735(2):159-70. Unique Identifier : AIDSLINE MED/20134192
- Lamotte C; Peytavin G; Farinotti R; Service de Pharmacie Clinique et des Biomateriaux, Groupe; Hospitalier X.Bichat-C.Bernard, Paris, France.
- We developed and characterized a high-performance liquid chromatographic assay for the determination of nelfinavir (NFV), a potent HIV protease inhibitor, and its active metabolite M8 in human plasma. Extraction of the internal standard, M8 and NFV from the plasma buffered at pH 9.5 was achieved by a liquid-liquid ext
- Expression, purification and biological properties of the carboxyl half part of the HTLV-I surface envelope glycoprotein.
- J Chromatogr B Biomed Sci Appl. 2000 Jan 14;737(1-2):85-95. Unique Identifier : AIDSLINE MED/20143280
- Tallet B; Astier-Gin T; Londos-Gagliardi D; Guillemain B; EP630 CNRS-Universite Victor Segalen Bordeaux 2, France.
- The carboxyl half of the surface envelope protein of HTLV-I contains the major immunodominant and neutralizable domains. Using two affinity chromatography steps and a combination of high salt concentration and non-ionic detergent, we purified this part of the envelope protein from Escherichia coli. Analysis of some im
- Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.
- Clin Cancer Res. 2000 Jan;6(1):102-11. Unique Identifier : AIDSLINE MED/20120231
- Rempel SA; Dudas S; Ge S; Gutierrez JA; Henry Ford Midwest Neuro-Oncology Center, Department of; Neurosurgery, Henry Ford Health Sciences Center, Detroit,; Michigan 48202, USA. nssan@neuro.hfh.edu
- Glioblastoma multiforme (GBM) tumors display extensive histomorphological heterogeneity, with great variability in the extent of invasiveness, angiogenesis, and necrosis. The identification of genes associated with these phenotypes should further the molecular characterization, permitting better definition of glioma s
- Behavioral-diagnostic analysis of compliance with universal precautions among nurses.
- J Occup Health Psychol. 2000 Jan;5(1):127-41. Unique Identifier : AIDSLINE MED/20122001
- DeJoy DM; Searcy CA; Murphy LR; Gershon RR; Department of Health Promotion and Behavior, University of; Georgia, Athens 30602-6522, USA. ddejoy@coe.uga.edu
- This study used the PRECEDE model (L.W. Green, M.W. Kreuter, S.G. Deeds, & K.B. Partridge, 1980) to examine individual, job-task, and environmental-organizational factors related to compliance with universal precautions (UP) among nurses. Structural equation modeling showed that the hypothesized model did a better
- Nutrients and HIV: part one -- beta carotene and selenium.
- Altern Med Rev. 1999 Dec;4(6):403-13. Unique Identifier : AIDSLINE MED/20076811
- Patrick L
- Micronutrient deficiencies are common in HIV/AIDS, resulting from both malabsorption and virally-caused depletion. Beta carotene and selenium deficiencies, two of the most common nutrient deficiencies, are important due to their dual function as nutrients necessary for immune modulation and as antioxidants. Beta carot
- Acetyl-L-carnitine.
- Altern Med Rev. 1999 Dec;4(6):438-41. Unique Identifier : AIDSLINE MED/20076816
- Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and st
- Chemical process evolution of efavirenz, a potent non-nucleosidal HIV reverse transcriptase inhibitor.
- Enantiomer. 1999;4(6):599-608. Unique Identifier : AIDSLINE MED/20136402
- Chen CY; Tan L; Department of Process Research, Merck Research Laboratories,; Rahway, NJ 07065, USA. cheng_chen@merck.com
- Highly loaded nanoparticulate carrier using an hydrophobic antisense oligonucleotide complex.
- Eur J Pharm Sci. 1999 Dec;9(2):163-70. Unique Identifier : AIDSLINE MED/20089035
- Berton M; Allemann E; Stein CA; Gurny R; School of Pharmacy, University of Geneva, quai E.-Ansermet; CH-1211, Geneva, Switzerland.
- Antisense oligonucleotides, and particularly those with phosphorothioate backbones, have emerged as potential gene specific therapeutic agents and are currently undergoing evaluation in clinical trials for a variety of diseases. In the area of HIV-1 therapeutics, targeting of oligonucleotides to infected cells, such a
- Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity.
- Bioorg Med Chem Lett. 2000 Jan 3;10(1):87-90. Unique Identifier : AIDSLINE MED/20100206
- Dong Y; Venkatachalam TK; Narla RK; Trieu VN; Sudbeck EA; Uckun FM; Drug Discovery Program, Department of Chemistry, Hughes; Institute, St Paul, MN 55113, USA.
- In a systematic search for novel dual function antioxidants with potent anti-HIV activity, we evaluated 9 rationally designed non-nucleoside inhibitors (NNI) of HIV-1 RT for antioxidant and anti-HIV activities. Our lead phenethyl-5-bromopyridyl thiourea (PEPT) compounds, N-[2-(2-methoxyphenylethyl)]-N -[2-(5-bromopyri
- 5' Nuclease assays for the loci CCR5-+/Delta32, CCR2-V64I, and SDF1-G801A related to pathogenesis of AIDS.
- Clin Chem. 2000 Jan;46(1):24-30. Unique Identifier : AIDSLINE MED/20088722
- Yuan CC; Peterson RJ; Wang CD; Goodsaid F; Waters DJ; Laboratory of Genomic Diversity, National Cancer; Institute-Frederick Cancer Research and Development Center,; Frederick, MD 21702, USA.
- BACKGROUND: Variations within the human genome play important roles in human disease. To study variations related to susceptibility to AIDS, we have developed 5 nuclease assays that eliminate post-PCR molecular biology steps. METHODS: TaqMan assays based on the 5 nuclease activity of Taq polymerase and fluorescent r
- Simultaneous HPLC assay for quantification of indinavir, nelfinavir, ritonavir, and saquinavir in human plasma.
- Clin Chem. 2000 Jan;46(1):73-81. Unique Identifier : AIDSLINE MED/20088728
- Remmel RP; Kawle SP; Weller D; Fletcher CV; Departments of Medicinal Chemistry and Experimental and Clinical; Pharmacology, College of Pharmacy, University of Minnesota,; Minneapolis, MN 55455, USA. remme001@tc.umn.edu
- BACKGROUND: HIV protease inhibitors are recommended as part of combination antiretroviral therapy. Dual protease inhibitor therapy is also being used clinically. Consequently, a simultaneous assay for indinavir, nelfinavir,
- Clinical significance of serum soluble IL-2R levels in patients with adult T cell leukaemia (ATL) and HTLV-1 carriers.
- Clin Exp Immunol. 2000 Feb;119(2):259-63. Unique Identifier : AIDSLINE MED/20098463
- Araki K; Harada K; Nakamoto K; Shiroma M; Miyakuni T; Department of Medical Technology, School of Health Science,; Faculty of Medicine, University of the Ryukyu, Japan.; karaki@med.u-ryukyu.ac.jp
- The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the
- Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro.
- Clin Exp Immunol. 2000 Feb;119(2):299-304. Unique Identifier : AIDSLINE MED/20098469
- Brodskyn C; Beverley SM; Titus RG; Laboratorio de Imunologia, Departamento de Biointeracao,; Instituto de Ciencias da Saude, Universidade Federal da Bahia,; Bahia, Brazil.
- In this study we have compared the immune response of normal human cells cultured in vitro to two virulent strains of Leishmania major (CC1 and LV39), and to an avirulent vaccine strain (dhfr-ts-) made by targeted deletion of the essential gene DHFR-TS. We utilized an in vitro system in which naive T cells from normal
- Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response.
- Clin Exp Immunol. 2000 Feb;119(2):354-60. Unique Identifier : AIDSLINE MED/20098478
- Saegusa K; Ishimaru N; Yanagi K; Haneji N; Nishino M; Azuma M; Saito I; Hayashi Y; Department of Pathology, Tokushima University School of; Dentistry, Tokushima, Japan.
- Intraperitoneal administration with anti-CD86 (B7.2) MoAb into the murine model for primary SS in NFS/sld mutant mice resulted in dramatically inhibitory effects on the development of autoimmune lesions, while no significant effects were observed when the mice were administered with anti-CD80 (B7.1) MoAb. We found tha
- Finding a role for zalcitabine in the HAART era.
- Antivir Ther. 1998;3(3):125-37. Unique Identifier : AIDSLINE MED/20146711
- Moyle GJ; Gazzard BG; Kobler Clinic, Chelsea and Westminster Hospital, London, UK.
- Zalcitabine ( ddC ) is a nucleoside analogue reverse transcriptase inhibitor with demonstrated clinical benefit in combination use. More widespread use of zalcitabine has been limited by a number of factors including
- Meta-analysis of antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death.
- Antivir Ther. 1998;3(3):139-45. Unique Identifier : AIDSLINE MED/20146712
- Hill AM; DeMasi R; Dawson D; GlaxoWellcome, Greenford, Middlesex, UK. AMH21137@GGR.CO.UK
- There is uncertainty as to how the effects of antiretroviral treatments on human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4 cell counts can predict reductions in clinical progression to AIDS or death. A meta-analysis was conducted for 27 pairwise comparisons of antiretroviral treatments in 15 randomized
- Management of antiretroviral therapy for HIV infection: modelling when to change therapy.
- Antivir Ther. 1998;3(3):147-58. Unique Identifier : AIDSLINE MED/20146713
- D'Amato RM; D'Aquila RT; Wein LM; Operations Research Center, Massachusetts Institute of; Technology, Cambridge 02139, USA.
- OBJECTIVE: To evaluate four strategies for monitoring plasma HIV RNA levels and/or resistance genotypes to decide when to change antiretroviral therapy. The strategies include: (i) 1997 guidelines recommending a therapy switch when plasma RNA exceeds a threshold level; (ii) a viral load policy, using a fixed increase
- Improvement in immune function due to treatment with indinavir despite severe immune deficiency.
- Unique Identifier : AIDSLINE MED/20146714
- Rothen M; Bisset LR; Joller-Jemelka HI; Grob P; Luthy R; Opravil M; Division of Infectious Diseases and Hospital Epidemiology,; University Hospital Zurich, Switzerland.
- To study the virological, immunological and clinical effects of the protease inhibitor indinavir in human immunodeficiency virus (HIV)-infected patients with CD4 counts
- Prediction of HIV-1 RNA suppression and its durability during treatment with zidovudine/lamivudine.
- Unique Identifier : AIDSLINE MED/20146715
- Opravil M; Hill AM; DeMasi R; Dawson D
- To predict the probability of long-term viral suppression during treatment with zidovudine and lamivudine, human immunodeficiency virus type 1 (HIV-1) RNA values were retrospectively pooled for 1083 patients from six randomized, double-blind clinical trials. All analyses of HIV-1 RNA were obtained using the Roche Ampl
- Diminished HIV-1 sensitivity to stavudine in patients on prolonged therapy occurs only at low levels and cannot be attributed to any single amino acid substitution in reverse transcriptase.
- Antivir Ther. 1998;3(3):177-82. Unique Identifier : AIDSLINE MED/20146716
- Salomon H; Montaner JS; Belmonte A; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.
- To study the extent to which phenotypic resistance to stavudine occurs under therapy, we studied 18 pairs of human immunodeficiency virus type 1 (HIV-1) isolates from patients both prior to and following 24-48 weeks of treatment with stavudine monothe
- Genotypic and phenotypic resistance to stavudine after long-term monotherapy. BMS-020 Spanish Study Group.
- Antivir Ther. 1998;3(3):183-6. Unique Identifier : AIDSLINE MED/20146717
- Holguin A; Dietrich U; Immelmann A; Soriano V; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
- Protocol BMS 020 was a double-blind, prospective clinical trial in which two different doses of stavudine (20 and 40 mg twice daily) were compared in human immunodeficiency virus (HIV)-infected patients with previous exposure to zidovudine for longer
- Quantitative p24 antigenaemia for monitoring response to antiretroviral therapy in HIV-1 group O-infected patients.
- Antivir Ther. 1998;3(3):187-9. Unique Identifier : AIDSLINE MED/20146718
- Machuca A; Gutierrez M; Mur A; Soriano V; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
- Failure to recognize infection caused by human immunodeficiency virus type 1 (HIV-1) group O variants has been described using both serological and genetic techniques. Moreover, the monitoring of response to antiretroviral therapy is difficult in persons carrying this infection since most currently available tests for
- Anti-HIV antiviral activity of stavudine in a thymidine kinase-deficient cellular line.
- Antivir Ther. 1998;3(3):191-4. Unique Identifier : AIDSLINE MED/20146719
- Turriziani O; Simeoni E; Dianzani F; Antonelli G; Institute of Virology, University La Sapienza, Rome, Italy.; virosap@flashnet.it
- Stavudine ( d4T ) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. It is known that stavudine is metabolized in cells to the mono-, di- and tr
- Loss of lamivudine resistance in a zidovudine and lamivudine dual-resistant HIV-1 isolate after discontinuation of in vitro lamivudine drug pressure.
- Antivir Ther. 1998;3(4):203-7. Unique Identifier : AIDSLINE MED/20146720
- Rusconi S; De Pasquale MP; Milazzo L; Kurtagic S; Bulgheroni E; Citterio P; Galazzi M; La Seta Catamancio S; Galli M; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Italy. rusconi@imiucca.csi.unimi.it
- We examined the in vitro phenotypic and genotypic profiles of an extensively passaged human immunodeficiency virus type 1 clinical isolate which has been selected for lamivudine resistance, with an M184V mutation in a zidovudine-resistant genetic background, and then cultured with zidovudine alone. Our passaging strat
- Kinetics of productive and latent HIV infection in lymphatic tissue and peripheral blood during triple-drug combination therapy with or without additional interleukin-2.
- Antivir Ther. 1998;3(4):209-14. Unique Identifier : AIDSLINE MED/20146721
- Stellbrink HJ; Hufert FT; Tenner-Racz K; Lauer J; Schneider C; Albrecht H; Racz P; van Lunzen J; Medical Department, University Hospital Eppendorf, Hamburg,; Germany. stellbri@uke.uni-hamburg.de
- OBJECTIVE: To study decay rates of productively and latently infected cells in peripheral blood and lymph nodes during triple antiretroviral therapy and the possible impact of interleukin-2 ( IL-2 ) on viral kinetics. METHODS: In this non-randomized study, nine antiretro
- Low plasma concentrations of indinavir are related to virological treatment failure in HIV-1-infected patients on indinavir-containing triple therapy.
- Antivir Ther. 1998;3(4):215-20. Unique Identifier : AIDSLINE MED/20146722
- Burger DM; Hoetelmans RM; Hugen PW; Mulder JW; Meenhorst PL; Koopmans PP; Brinkman K; Keuter M; Dolmans W; Hekster YA; Department of Clinical Pharmacy, University Hospital Nijmegen,; The Netherlands. D.Burger@klinfarm.azn.nl
- All human immunodeficiency virus type 1 (HIV-1)-infected patients who started to use indinavir (800 mg three times a day) as part of their triple drug regimen were included in a study to determine the importance of low plasma concentrations of indinav
- Evaluation of mixtures of wild-type HIV-1 and HIV-1 with resistance point mutations against reverse transcriptase inhibitors.
- Antivir Ther. 1998;3(4):221-7. Unique Identifier : AIDSLINE MED/20146723
- Villahermosa ML; Contreras G; Perez-Alvarez L; Bru F; Medrano L; Delgado E; Colomo C; Thomson M; Najera R; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, Madrid, Spain.
- The presence of resistance-related mutations in 185 serial proviral DNA samples from 108 HIV-infected patients was monitored using the line probe assay (LiPA). The proportions of wild-type and mutant virus in each sample were determined. Subsequent samples from the same patient were analysed. Resistance mutations were
- Opportunistic infections shortly after beginning highly active antiretroviral therapy.
- Antivir Ther. 1998;3(4):229-31. Unique Identifier : AIDSLINE MED/20146724
- Rodriguez-Rosado R; Soriano V; Dona C; Gonzalez-Lahoz J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; SaludCarlos III, Madrid, Spain. rafael.rodriguez@mad.servicom.es
- The clinical benefit of highly active antiretroviral therapy (HAART) has been attributed to its suppression of viral replication and improvement in the CD4 lymphocyte count. However, the development of clinical symptoms secondary to previously silent opportunistic pathogens shortly after beginning HAART has been repor
- Combination treatment for hepatitis C can be hazardous in patients co-infected with HIV [letter]
- Unique Identifier : AIDSLINE MED/20146725
- Schvarcz R; Moberg L; Sonnerborg A
- Hepatitis B virus antiviral drug resistance: from the laboratory to the patient.
- Antivir Ther. 1998;3(4):243-6. Unique Identifier : AIDSLINE MED/20146728
- Mutimer D; Liver & Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham,; UK. david.mutimer@university-b.wmids.nhs.uk
- The development and application of nucleoside (and nucleotide) analogues for the treatment of chronic hepatitis B infection will transform the management of this condition. For instance, treatment with lamivudine effects a dramatic and measurable reduction of serum virus titre. This is associated with biochemical and
- Laboratory markers of antiviral activity.
- Antivir Ther. 1998;3(4):247-50. Unique Identifier : AIDSLINE MED/20146729
- Christopherson C; Lu SD; Kwok S; Roche Molecular Systems, Alameda, CA 94501, USA.
- Quantitative assays for viral nucleic acids have been instrumental in monitoring the response of patients to various antiviral therapies. The level of viraemia is predictive of clinical outcome in that a reduced risk of progression to AIDS or death was observed with lower plasma human immunodeficiency virus (HIV) RNA
- Stavudine resistance: an update on susceptibility following prolonged therapy.
- Unique Identifier : AIDSLINE MED/20146706
- Lin PF; Gonzalez CJ; Griffith B; Friedland G; Calvez V; Ferchal F; Schinazi RF; Shepp DH; Ashraf AB; Wainberg MA; Soriano V; Mellors JW; Colonno RJ; Bristol-Myers Squibb, Wallingford, Conn., USA. linp@bms.com
- The current report summarizes the available published and unpublished data from several investigators on resistance in clinical isolates following prolonged stavudine therapy. Results suggest that stavudine resistance is both modest in degree and infr
- Induction and maintenance treatment regimens for HIV-1 infection in vitro.
- Antivir Ther. 1999;4(1):29-34. Unique Identifier : AIDSLINE MED/20146707
- Oh MD; Merrill DP; Hirsch MS; Department of Medicine, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA.
- Can aggressive anti-human immunodeficiency virus (HIV) induction regimens be simplified after sufficient virus suppression is achieved? In vitro studies were conducted to evaluate the hypothesis that aggressive induction regimens could be followed by less aggressive maintenance regimens. A clinical HIV-1 isolate and l
- Quality of life outcomes of saquinavir, zalcitabine and combination saquinavir plus zalcitabine therapy for adults with advanced HIV infection with CD4 counts between 50 and 300 cells/mm3.
- Antivir Ther. 1999;4(1):35-44. Unique Identifier : AIDSLINE MED/20146708
- Revicki DA; Swartz C; Wu AW; Haubrich R; Collier AC; MEDTAP International Inc., Bethesda, Md., USA. revicki@medtap.com
- BACKGROUND: Benefits in patient health-related quality of life (HRQL) have not yet been demonstrated for combination antiretroviral therapy with protease inhibitors and nucleoside analogues. This double-blind study evaluated zalcitabine or saquinavir monotherapy and
- Presence of genotypic resistance in nucleoside analogue-treated HIV-1-infected patients with undetectable viral load.
- Antivir Ther. 1999;4(1):45-9. Unique Identifier : AIDSLINE MED/20146709
- Rubio A; Gomez-Cano M; Puig T; Leal M; Perez-Olmeda M; Ruiz L; Clotet B; Rey C; Zamora L; Xaus N; Soriano V; Department of Biochemistry, Virgen del Rocio University Hospital,; Seville, Spain.
- Patients harbouring drug-resistance viruses usually suffer a rise in serum viraemia after a variable period of time. We have investigated the relationship between the appearance of resistant genotypes and the viral load of each patient after treatment. Our objective was to assess the association between human immunode
- Retroviruses et opportunistic infections '99 [editorial]
- Antivir Ther. 1999;4(1):5-6. Unique Identifier : AIDSLINE MED/20146703
- Lange JM; Richman DD
- Acute hypersensitivity with delavirdine [letter]
- Antivir Ther. 1999;4(1):51. Unique Identifier : AIDSLINE MED/20146710
- Mills G; Morgan J; Hales G; Smith D
- Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation.
- Antivir Ther. 1999;4(1):7-14. Unique Identifier : AIDSLINE MED/20146704
- Cane PA; Mutimer D; Ratcliffe D; Cook P; Beards G; Elias E; Pillay D; PHLS Antiviral Susceptibility Reference Unit, University of; Birmingham Medical School, UK. p.cane@bham.ac.uk
- This report describes nucleotide sequence analysis of part of the polymerase gene of hepatitis B virus (HBV) during the development of lamivudine-resistant HBV in five patients who received lamivudine treatment in conjunction with liver transplantation. Samples from patients were analysed before, during and after drug
- Effect of weekly adefovir (PMEA) infusions on HIV-1 virus load: results of a phase I/II study.
- Antivir Ther. 1999;4(2):101-7. Unique Identifier : AIDSLINE MED/20146736
- Kamp W; Schokker J; Cambridge E; De Jong S; Schuurman R; De Groot T; Boucher CA; Fight for Life Foundation, Amsterdam, The Netherlands.
- The compound 9-(2-phosphonylmethoxyethyl)adenine (adefovir; PMEA) is a potent inhibitor of a number of viruses in vitro, such as human immunodeficiency virus (HIV) type 1 and 2, herpes simplex virus (HSV) type 1 and 2, human papillomavirus virus (HBV) and Epstein-Barr virus (EBV). Adefovir also proved to be effective
- Kinetics of beta-chemokine levels during anti-HIV therapy.
- Antivir Ther. 1999;4(2):109-15. Unique Identifier : AIDSLINE MED/20146737
- Aleman S; Pehrson P; Sonnerborg A; Division of Clinical Virology, Karolinska Institutet, Huddinge; University Hospital, Sweden. soki@labd01.hs.sll.se
- Chemokines are pro-inflammatory cytokines that inhibit human immunodeficiency virus type 1 (HIV-1) replication in vitro. We studied the kinetics of the beta-chemokines, macrophage inhibitory protein (MIP)-1 alpha, MIP-1 beta, RANTES, and monocyte chemotactic protein (MCP)-1 in plasma during 12 months of antiretroviral
- Patients failing saquinavir therapy require an early change to indinavir before HIV-1 viral load reaches high levels.
- Antivir Ther. 1999;4(2):117-21. Unique Identifier : AIDSLINE MED/20146738
- Dronda F; Perez-Elias MJ; Antela A; Casado JL; Marti-Belda P; Cobo J; Unidad de Enfermedades Infecciosas, Hospital Ramon y Cajal,; Universidad de Alcala, Madrid, Spain. fdronda@hrc.insalud.es
- Sequential use of antiretroviral therapy with protease inhibitors (PI) is frequently prescribed owing to failure or intolerance of the first selected agent. Controversial data exist about the virological and immunological outcome of patients in whom a change to a se
- Efficiency of drug resistance genotypic tests in specimens with low HIV viral load.
- Antivir Ther. 1999;4(2):123-4. Unique Identifier : AIDSLINE MED/20146739
- Gomez-Cano M; Rubio A; Ruiz L; Perez-Olmeda M; Leal M; Clotet B; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- The early recognition of resistance to antiretroviral agents could allow a rapid switch in therapy and therefore avoid the accumulation of mutations and reduce the risk of cross-resistance. However, the efficiency of genotypic tests in specimens with low viral load (VL) is severely compromised since human immunodefici
- Different outcome in the first two patients with an HIV-1 multinucleoside drug-resistant T69SSS insertion in Spain.
- Antivir Ther. 1999;4(2):125-7. Unique Identifier : AIDSLINE MED/20146740
- Briones C; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- A novel multidrug-resistance mechanism has been described in human immunodeficiency virus type 1 (HIV-1), which involves the insertion of 6 bp between codons 69 and 70 in the reverse transcriptase (RT) gene. Herein, we report the first two patients in Spain carrying viral population
- Effective salvage therapy for HIV-1 infection--an unmet challenge [editorial]
- Antivir Ther. 1999;4(2):59-60. Unique Identifier : AIDSLINE MED/20146730
- Montaner JS; Mellors JW
- Zidovudine resensitization and dual HIV-1 resistance to zidovudine and lamivudine in the delta lamivudine roll-over study.
- Antivir Ther. 1999;4(2):69-77. Unique Identifier : AIDSLINE MED/20146732
- Masquelier B; Descamps D; Carriere I; Ferchal F; Collin G; Denayrolles M; Ruffault A; Chanzy B; Izopet J; Buffet-Janvresse C; Schmitt MP; Race E; Fleury HJ; Aboulker JP; Yeni P; Brun-Vezinet F; Laboratoire de Virologie, University Hospital of Bordeaux,; France. bernard.masquelier@viro.u-bordeaux2.fr
- OBJECTIVE: To study zidovudine resensitization and dual resistance to zidovudine/lamivudine in HIV-1 isolates from nucleoside reverse transcriptase (RT) inhibitor-experienced patients during selective pressure exerted by zidovudine/lamivudine combination therapy . DESIG
- AVANTI 1: randomized, double-blind trial to evaluate the efficacy and safety of zidovudine plus lamivudine versus zidovudine plus lamivudine plus loviride in HIV-infected antiretroviral-naive patients. AVANTI Study Group.
- Antivir Ther. 1999;4(2):79-86. Unique Identifier : AIDSLINE MED/20146733
- Gatell J; Lange J; Gartland M; Glaxo Wellcome Research and Development, Middlesex, UK.
- The objective of this randomized double-blind, placebo-controlled trial was to investigate the effect of combination antiretroviral therapy on plasma HIV-1 RNA as measured by HIV RNA PCR and to assess the safety and tolerability of such regimens. The trial was carried out in seven European countries,
- In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA.
- Antivir Ther. 1999;4(2):87-94. Unique Identifier : AIDSLINE MED/20146734
- Wainberg MA; Miller MD; Quan Y; Salomon H; Mulato AS; Lamy PD; Margot NA; Anton KE; Cherrington JM; McGill University AIDS Center, Jewish General Hospital, Montreal,; Quebec, Canada.
- 9-(2-phosphonomethoxypropyl)adenine (PMPA) has demonstrated remarkable anti-simian immunodeficiency virus (SIV) activity in macaque models of SIV infection and transmission prevention. Recently, PMPA and its oral prodrug, bis-POC PMPA, have also shown potent anti-human immunodeficiency virus type 1 (HIV-1) activity in
- A combination of nucleoside analogues and a protease inhibitor reduces HIV-1 RNA levels in semen: implications for sexual transmission of HIV infection.
- Antivir Ther. 1999;4(2):95-9. Unique Identifier : AIDSLINE MED/20146735
- Liuzzi G; Chirianni A; Bagnarelli P; Clementi M; Piazza M; Istituto Malattie Infettive, Universita di Napoli Federico II,; Naples, Italy.
- Direct contact with semen is the major route of sexual acquisition of human immunodeficiency virus (HIV) in homosexual and heterosexual partners of seropositive men. In this study, we show that concentrations of HIV-1 RNA molecules in plasma and semen of seropositive patients are related to the duration and type of an
- Acetylcysteine. Fluimucil, Mucomyst, N-acetylcysteine, NAC, NSC 111180.
- Drugs R D. 1999 Oct;2(4):265-6. Unique Identifier : AIDSLINE MED/20124631
- Aldesleukin. Interleukin-2 (IL-2), IL-2 (Chiron), Macrolin, Proleukin, recombinant IL-2 (Chiron), T cell growth factor.
- Drugs R D. 1999 Oct;2(4):267-70. Unique Identifier : AIDSLINE MED/20124632
- Interferon-alpha-n3. Alferon, Alferon LDO, Alferon N, Alferon N Gel, Altemol, natural alpha interferon, alpha-n3-IF.
- Drugs R D. 1999 Oct;2(4):271-3. Unique Identifier : AIDSLINE MED/20124633
- Microvolume fluorimetry for the determination of absolute CD4 and CD8 lymphocyte counts in patients with HIV: a comparative evaluation.
- Clin Lab Haematol. 1999 Dec;21(6):391-5. Unique Identifier : AIDSLINE MED/20138634
- Glencross D; Scott L; Aggett H; Sonday S; Scott CS; Department of Haematology, South African Institute for Medical; Research, Johannesburg Hospital, Johannesburg, South Africa.
- This study compared CD4 and CD8 lymphocyte counts obtained by microvolume fluorimetry (MVF) with those derived by flow cytometry (FC). Samples from 192 patients with known or suspected HIV were analysed, and the distribution of CD4 counts for these samples ranged from 0 and 1,279/microl, with 142/192 (74%) of the samp
- Association of HLA-DQ and -DR alleles with protection from or infection with HIV-1.
- Exp Mol Pathol. 2000 Feb;68(1):21-8. Unique Identifier : AIDSLINE MED/20108856
- Roe DL; Lewis RE; Cruse JM; Department of Pathology, University of Mississippi Medical; Center, Jackson, Mississippi, 39216, USA.
- Infection with human immunodeficiency virus type 1 (HIV-1) and progression to acquired immune deficiency syndrome (AIDS) are controlled by both host genetic factors and viral factors. The HLA (human leukocyte antigen) region in humans controls immune response functions and tissue rejection and influences susceptibilit
- Granulomatous Pneumocystis carinii pneumonia in Wegener's granulomatosis.
- Eur Respir J. 2000 Jan;15(1):213-6. Unique Identifier : AIDSLINE MED/20142117
- Ullmer E; Mayr M; Binet I; Ebnother-Staub C; Dalquen P; Soler M; Tamm M; Division of Pneumology, University Hospital Basel, Switzerland.
- This study reports on a first case of granulomatous Pneumocystis carinii pneumonia (PCP) in a human immunodeficiency virus-negative patient with antineutrophil cytoplasmic antibody-positive Wegener s granulomatosis whilst receiving immunosuppressive treatment. The patient presented with diffuse alveolar haemorrhage, p
- Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society.
- Eur Respir J. 2000 Jan;15(1):217-31. Unique Identifier : AIDSLINE MED/20142118
- de Blic J; Midulla F; Barbato A; Clement A; Dab I; Eber E; Green C; Grigg J; Kotecha S; Kurland G; Pohunek P; Ratjen F; Rossi G
- A disulfide conjugate between anti-tetanus antibodies and HIV (37-72)Tat neutralizes tetanus toxin inside chromaffin cells.
- FEBS Lett. 1999 Sep 24;458(3):383-6. Unique Identifier : AIDSLINE MED/20035722
- Stein S; Weiss A; Adermann K; Lazarovici P; Hochman J; Wellhoner H; Institute of Legal Medicine, University of Hamburg, Germany.
- Conjugates between anti-tetanus F(ab )2 fragments and the (37-72) fragment of the HIV Tat protein were taken up by chromaffin cells, NG108-15 neurohybridoma cells and Rev-2-T-6 lymphoma cells. The uptake could not be inhibited by competition with (37-72)Tat, but was reduced in the presence of metabolic inhibitors or a
- NMR structure of the mature dimer initiation complex of HIV-1 genomic RNA.
- FEBS Lett. 1999 Sep 24;458(3):387-92. Unique Identifier : AIDSLINE MED/20035723
- Mujeeb A; Parslow TG; Zarrinpar A; Das C; James TL; Department of Pharmaceutical Chemistry, University of California; at San Francisco, 94143, USA.
- The two identical genomic RNA strands inside each HIV-1 viral particle are linked through homodimerization of an RNA stem-loop, termed SL1, near their 5 ends. SL1 first dimerizes through a palindromic sequence in its loop, forming a transient kissing-loop complex which then refolds to a mature, linear duplex. We prev
- Accuracy of endoscopic databases for assessing patient symptoms: comparison with self-reported questionnaires in patients infected with the human immunodeficiency virus [see comments]
- Gastrointest Endosc. 2000 Feb;51(2):129-33. Unique Identifier : AIDSLINE MED/20117752
- Corley DA; Cello JP; Koch J; Division of Gastroenterology, and the Gastroenterology Clinical; Outcomes and Epidemiology Research Group, University of; California, San Francisco 94143-0538, USA.
- BACKGROUND: Endoscopic databases are increasingly used for clinical research, but their validity as research instruments has not been assessed. We compared the accuracy of endoscopic indications recorded in an endoscopic database with patient symptom questionnaires. METHODS: All patients infected with the human immuno
- Oral Kaposi's sarcoma in a non-AIDS patient.
- Gen Dent. 1999 Jul-Aug;47(4):413-5. Unique Identifier : AIDSLINE MED/20152088
- Bowie SA Jr; Bach D; Medical University of South Carolina School of Dentistry, USA.
- Kaposi s sarcoma involving the oral cavity is seen frequently in AIDS patients but rarely in transplant patients. When the oral cavity is involved in transplant patients, it usually is located on the palate or the oropharynx. This article reports a renal transplant patient who developed Kaposi s sarcoma which mimicked
- Not all patients are the same: systemic risk factors for adult periodontitis.
- Gen Dent. 1999 Nov-Dec;47(6):580-8. Unique Identifier : AIDSLINE MED/20152068
- Wilson TG; University of Texas at San Antonio Dental School, USA.
- Periodontal diseases are viewed today as multifactoral problems that are initiated and sustained by bacteria but significantly modified by the body s response to bacterial plaque. Local and systemic risk factors are involved in the disease process and both should be included when prognosis and treatment plans are deve
- Long-term immune recovery after CD34+ immunoselected and unselected peripheral blood progenitor cell transplantation: a case-control study.
- Haematologica. 1999 Dec;84(12):1100-3. Unique Identifier : AIDSLINE MED/20054321
- Laurenti L; Sica S; Sora F; Piccirillo N; Ortu La Barbera E; Chiusolo P; Salutari P; Rumi C; Rutella S; Leone G; Divisione di Ematologia, Istituto Semeiotica Medica, Universita; Cattolica Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy.; emacat@rm.unicatt.it
- BACKGROUND AND OBJECTIVE: CD34+ stem cell selection induces extensive T-cell depletion as a consequence of ex vivo manipulation. The impact of T-cell depletion on long-term immunologic recovery after autologous CD34+ peripheral blood progenitor cell transplantation (CD34+ PBPCT) is not well characterized. We compared
- Polymorphisms of the human IFNG gene noncoding regions.
- Immunogenetics. 2000 Jan;51(1):50-8. Unique Identifier : AIDSLINE MED/20130133
- Bream JH; Carrington M; O'Toole S; Dean M; Gerrard B; Shin HD; Kosack D; Modi W; Young HA; Smith MW; Laboratory of Experimental Immunology, National Cancer Institute,; Frederick, Maryland 21702-1201, USA.
- Interferon gamma (IFN-gamma) is a multifunctional cytokine that is essential in the development of Th1 cells and in cellular responses to a variety of intracellular pathogens including human immunodeficiency virus (HIV-1). We screened genomic DNA samples from a predominately Caucasian male population of HIV-infected a
- Diagnostic accuracy of physician review, expert algorithms and data-derived algorithms in adult verbal autopsies.
- Int J Epidemiol. 1999 Dec;28(6):1081-7. Unique Identifier : AIDSLINE MED/20125293
- Quigley MA; Chandramohan D; Rodrigues LC; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
- BACKGROUND: The verbal autopsy (VA) is used to collect information on cause-specific mortality from bereaved relatives. A cause of death may be assigned by physician review of the questionnaires, or by an algorithm. We compared the diagnostic accuracy of physician review, an expert algorithm, and data-derived algorith
- An age-period-cohort analysis of 50,875 AIDS cases among injecting drug users in Europe.
- Int J Epidemiol. 1999 Dec;28(6):1141-8. Unique Identifier : AIDSLINE MED/20125302
- Houweling H; Wiessing LG; Hamers FF; Termorshuizen F; Gill ON; Sprenger MJ; Department of Infectious Diseases Epidemiology, National; Institute of Public Health and the Environment (RIVM), Bilthoven,; The Netherlands. hans.houweling@gr.nl
- BACKGROUND: The long average incubation time from HIV infection to AIDS makes it difficult to estimate recent HIV transmission from AIDS incidence data. Age-period-cohort (APC) analysis can separate out the effects of age, calendar time and birth cohort to provide a clearer picture of transmission trends. METHODS: AID
- Trends in HIV and AIDS based on HIV/AIDS surveillance data in Japan.
- Int J Epidemiol. 1999 Dec;28(6):1149-55. Unique Identifier : AIDSLINE MED/20125303
- Matsuyama Y; Hashimoto S; Ichikawa S; Nakamura Y; Kidokoro T; Umeda T; Kamakura M; Kimura S; Fukutomi K; Ikeda C; Kihara M; Biostatistics/Epidemiology and Preventive Health Sciences, School; of Health Sciences and Nursing, University of Tokyo, Japan.; matuyama@epistat.m.u-tokyo.ac.jp
- BACKGROUND: In recent years a decline in the number of new AIDS cases has been observed in several industrialized countries. It is important to know whether these recent trends observed in North America and Europe are also occurring in Japan . METHODS: The number of people reported w
- AIDS incidence and survival in a hospital-based cohort of asymptomatic HIV seropositive patients in Sao Paulo, Brazil.
- Int J Epidemiol. 1999 Dec;28(6):1156-60. Unique Identifier : AIDSLINE MED/20125304
- Fonseca LA; Reingold AL; Casseb JR; Brigido LF; Duarte AJ; University of California, Berkeley, School of Public Health, USA.
- BACKGROUND: In spite of the high incidence of AIDS in Brazil , few studies have tried to evaluate the prognosis of asymptomatic HIV seropositive Brazilian patients. METHODS: A hospital outpatient facility-based cohort of HIV seropositive asymptomatic subjects was followed to determi
- The deadly return of tuberculosis.
- Int Nurs Rev. 1999 Nov-Dec;46(6):176-7, 180. Unique Identifier : AIDSLINE MED/20139159
- Harrington J
- South Africa responds to a TB emergency [interview]
- Int Nurs Rev. 1999 Nov-Dec;46(6):178, 181. Unique Identifier : AIDSLINE MED/20139160
- Molefe M
- A strong nursing role in tuberculosis control [interview]
- Int Nurs Rev. 1999 Nov-Dec;46(6):179, 182. Unique Identifier : AIDSLINE MED/20139161
- Boutotte J
- Kininogens and kallikrein in pruritic papular eruption.
- Immunopharmacology. 1999 Dec;45(1-3):115-20. Unique Identifier : AIDSLINE MED/20080662
- Reis ML; Maeda S; Rosatelli JB; Donadi EA; Roselino AM; Laboratory of Pharmacology, Faculty of Pharmaceutical Science,; University of Sao Paulo, Ribeirao Preto, SP, Brazil.; mldreis@usp.br
- Pruritic papular eruption (PPE) is a common inflammatory cutaneous lesion observed only in HIV/AIDS patients. Since kinin is an important mediator in inflammation, we evaluated the levels of total kininogen (TKg), low and high molecular weight kininogen (LKg and HKg, respectively) and the activity of kallikrein in pla
- Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant.
- Immunopharmacology. 2000 Jan;46(1):29-37. Unique Identifier : AIDSLINE MED/20127543
- Azuma T; Watanabe N; Yagisawa H; Hirata H; Iwamura M; Kobayashi Y; Department of Biomolecular Science, Faculty of Science, Toho; University, Funabashi, Chiba, Japan.
- Two types of immunosuppressants, cycloprodigiosin hydrochloride (cPrG) and L-leucyl-L-leucine methyl ester (LeuLeuOMe), both have the ability to selectively inhibit the lysosomal function, and a related compound to cPrG, prodigiosin 25-C, and LeuLeuOMe have been reported to selectively inhibit the T cell function in v
- Mexican and Mexican American women in a battered women's shelter: barriers to condom negotiation for HIV/AIDS prevention.
- Issues Ment Health Nurs. 1999 Jul-Aug;20(4):333-55. Unique Identifier : AIDSLINE MED/20089362
- Davila YR; Brackley MH; University of Texas Health Science Center, San Antonio, USA.
- Anecdotal information suggests that, for Hispanic women who are involved with abusive partners, condom use request as an HIV/AIDS sexual risk-reduction behavior may expose the women to risk of both abuse and HIV/AIDS. A qualitative study explored barriers to condom negotiation for HIV/AIDS prevention among Mexican and
- HLA-class I-specific inhibitory receptors in HIV-1 infection.
- Hum Immunol. 2000 Jan;61(1):74-81. Unique Identifier : AIDSLINE MED/20122090
- De Maria A; Moretta L; Department of Internal Medicine, University of Genova, Italy.
- One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou
- beta-lactams: variations on a chemical theme, with some surprising biological results.
- J Antimicrob Chemother. 1999 Dec;44(6):729-34. Unique Identifier : AIDSLINE MED/20059773
- Hamilton-Miller JM; Department of Medical Microbiology, Royal Free and University; College Medical School, London, UK. j.hamilton-miller@rfhsm.ac.uk
- Cost-effectiveness of azithromycin for preventing Mycobacterium avium complex infection in HIV-positive patients in the era of highly active antiretroviral therapy.The Swiss HIV Cohort Study.
- Unique Identifier : AIDSLINE MED/20059784
- Sendi PP; Craig BA; Meier G; Pfluger D; Gafni A; Opravil M; Battegay M; Bucher HC
- We conducted a cost-effectiveness analysis to determine the clinical and economic consequences of Mycobacterium avium complex (MAC) prophylaxis in HIV-infected patients in the era of highly active antiretroviral therapy (HAART) in a health care system with access unrestricted by financial barriers. The analysis was pe
- beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.
- J Biol Chem. 2000 Jan 28;275(4):2479-85. Unique Identifier : AIDSLINE MED/20112807
- Cheng ZJ; Zhao J; Sun Y; Hu W; Wu YL; Cen B; Wu GX; Pei G; Shanghai Institute of Cell Biology, Chinese Academy of Sciences,; Shanghai 200031, People's Republic of China.
- The chemokine receptor CXCR4 has recently been shown to be a co-receptor involved in the entry of human immunodeficiency virus type 1 into target cells. This study shows that coexpression of beta-arrestin with CXCR4 in human embryonic kidney 293 cells attenuated chemokine-stimulated G protein activation and inhibition
- The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells.
- J Biol Chem. 2000 Jan 28;275(4):2654-60. Unique Identifier : AIDSLINE MED/20112831
- Rohr O; Schwartz C; Hery C; Aunis D; Tardieu M; Schaeffer E; Unite 338 INSERM, 5 rue Blaise Pascal, 67084 Strasbourg Cedex,; France.
- Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system and plays a direct role in the pathogenesis of AIDS dementia . However, the molecular mechanisms underlying HIV-1 expression in the central nervous system are poorly understood. We have recently reported
- Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.
- J Biol Chem. 2000 Jan 28;275(4):2852-8. Unique Identifier : AIDSLINE MED/20112857
- Huang N; Miller WL; Department of Pediatrics, University of California, San; Francisco, San Francisco, California 94143-0978, USA.
- The cholesterol side-chain cleavage enzyme, cytochrome P450scc, initiates the biosynthesis of all steroid hormones. Adrenal and gonadal strategies for P450scc gene transcription are essentially identical and depend on the orphan nuclear receptor steroidogenic factor-1, but the placental strategy for transcription of P
- Stability-activity relationships of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors. A basis for anti-HIV drug design.
- J Biol Chem. 2000 Feb 4;275(5):3421-30. Unique Identifier : AIDSLINE MED/20119302
- Jing N; De Clercq E; Rando RF; Pallansch L; Lackman-Smith C; Lee S; Hogan ME; Department of Molecular Physiology, Baylor College of Medicine,; Houston, Texas 77030, USA.
- Recently, we have demonstrated that T30695, a G-tetrad-forming oligonucleotide, is a potent inhibitor of human immunodeficiency virus, type I (HIV-1) integrase and the K(+)-induced loop folding of T30695 plays a key role in the inhibition of HIV-1 integrase (Jing, N., and Hogan, M. E. (1998) J. Biol. Chem. 273, 34992-
- Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.
- J Biol Chem. 2000 Feb 4;275(5):3693-8. Unique Identifier : AIDSLINE MED/20119335
- Choi J; Liu RM; Kundu RK; Sangiorgi F; Wu W; Maxson R; Forman HJ; Department of Molecular Pharmacology, University of Southern; California School of Pharmacy, Los Angeles, California 90033,; USA.
- Human immunodeficiency virus (HIV) progressively depletes GSH content in humans. Although the accumulated evidence suggests a role of decreased GSH in the pathogenesis of HIV, significant controversy remains concerning the mechanism of GSH depletion, especially in regard to envisioning appropriate therapeutic strategi
- HTLV-1-induced cell fusion is limited at two distinct steps in the fusion pathway after receptor binding.
- J Cell Sci. 2000 Jan;113 ( Pt 1):37-44. Unique Identifier : AIDSLINE MED/20059810
- Daenke S; Booth S; Nuffield Department of Clinical Medicine, University of Oxford,; John Radcliffe Hospital, Oxford OX3 9DU, UK.; sdaenke@molbiol.ox.ac.uk.
- Human T-cell leukemia virus type 1 (HTLV-1) is notable among retroviruses for its poor ability to infect permissive cells, particularly as cell free virus. The virus is most efficiently transmitted between individuals by infected cells, where it is presumed that intracellular particles and viral RNA are transferred to
- Viral sexually transmitted infections: current management strategies.
- J Clin Pharm Ther. 1999 Dec;24(6):409-14. Unique Identifier : AIDSLINE MED/20117867
- Tariq A; Ross JD; Department of GU Medicine, New Cross Hospital, Wolverhampton,; U.K.
- Viral sexually transmitted infections are a major health problem associated with considerable morbidity. This article reviews the current strategies used in the management of infections such as genital warts, genital herpes and molluscum contagiosum. Pros and cons of different ts
- Neurocognitive complaints in HIV-infection and their relationship to depressive symptoms and neuropsychological functioning.
- J Clin Exp Neuropsychol. 1999 Dec;21(6):737-56. Unique Identifier : AIDSLINE MED/20119371
- Rourke SB; Halman MH; Bassel C; Department of Psychiatry, University of Toronto, ONT, Canada.; sean.rourke@utoronto.ca
- We examined the degree to which depressive symptoms, clinical staging of HIV disease, and neuropsychological (NP) functioning were related to neurocognitive complaints in HIV-infection. One hundred adults with HIV-infection (12 asymptomatic, 41 mildly symptomatic, and 47 with AIDS) were administered NP tests of attents
- Neuropsychiatric correlates of memory-metamemory dissociations in HIV-infection.
- J Clin Exp Neuropsychol. 1999 Dec;21(6):757-68. Unique Identifier : AIDSLINE MED/20119372
- Rourke SB; Halman MH; Bassel C; Department of Psychiatry, University of Toronto, ONT, Canada.; sean.rourke@utoronto.ca
- Ninety-one adults with HIV-infection who varied in the concordance between their subjective memory complaints (or metamemory) on the Patient s Assessment of Own Functioning (Chelune, Heaton, & Lehman, 1986) and their memory performance on the California Verbal Learning Test (CVLT), were compared on the Beck Depress
- Effects of depressed mood versus clinical depression on neuropsychological test performance among African American men impacted by HIV/AIDS.
- J Clin Exp Neuropsychol. 1999 Dec;21(6):769-83. Unique Identifier : AIDSLINE MED/20119373
- Richardson MA; Satz PF; Myers HF; Miller EN; Bing EG; Fawzy FI; Maj M; Department of Psychiatry, Neuropsychiatric Institute, University; of California, Los Angeles, CA, USA. Mark.Richardson@bmc.org
- The utility of self-report measures in identifying those at risk for depressive disorder and the adverse impact of depression versus depressed mood and HIV serostatus on neuropsychological (NP) test performance were examined in a large sample (N = 243) of gay and bisexual African American men. Results indicate high ra
- Clinical application of the Quantiplex HCV RNA 2.0 and Amplicor HCV Monitor assays for quantifying serum hepatitis C virus RNA.
- J Clin Pathol. 1999 Nov;52(11):807-11. Unique Identifier : AIDSLINE MED/20154758
- Yu ML; Chuang WL; Chen SC; Lin ZY; Hsieh MY; Wang LY; Chang WY; Department of Internal Medicine, Kaohsiung Medical College; Hospital, Taiwan, Republic of China.
- AIM: To compare the performance characteristics and clinical application of two different technologies for quantifying serum hepatitis C virus (HCV) RNA levels. METHODS: HCV RNA was quantified by Amplicor HCV Monitor assay (Amplicor) and Quantiplex HCV RNA 2.0 assay (bDNA-2) in 119 sera from 107 HCV infected patients.
- Multiple eruptive dermatofibromas in a patient with HIV infection: case report and literature review.
- J Cutan Pathol. 2000 Jan;27(1):54-6. Unique Identifier : AIDSLINE MED/20123529
- Kanitakis J; Carbonnel E; Delmonte S; Livrozet JM; Faure M; Claudy A; Department of Dermatology, Hopital Ed. Herriot, Lyon, France.; kanitak@lyon151.inserm.fr
- Multiple eruptive dermatofibromas have been reported in the setting of autoimmune diseases treated with immunosuppressive drugs and more recently in the course of human immunodeficiency virus (HIV) infection. We report herein the ninth case of multiple eruptive dermato fibromas associated with HIV infection. The relev
- PCR-derived ssDNA probes for fluorescent in situ hybridization to HIV-1 RNA.
- J Histochem Cytochem. 2000 Feb;48(2):285-94. Unique Identifier : AIDSLINE MED/20107151
- Knuchel MC; Graf B; Schlaepfer E; Kuster H; Fischer M; Weber R; Cone RW; Division of Infectious Diseases, Department of Internal Medicine,; University Hospital Zurich, Zurich, Switzerland.
- We developed a simple and rapid technique to synthesize single-stranded DNA (ssDNA) probes for fluorescent in situ hybridization (ISH) to human immunodeficiency virus 1 (HIV-1) RNA. The target HIV-1 regions were amplified by the polymerase chain reaction (PCR) and were simultaneously labeled with dUTP. This product se
- Hospital infection control in an era of HIV infection and multi-drug resistant tuberculosis.
- J Hosp Infect. 2000 Jan;44(1):5-11. Unique Identifier : AIDSLINE MED/20100801
- Hannan MM; Azadian BS; Gazzard BG; Hawkins DA; Hoffman PN; Medical Microbiology Department, Department of HIV/GUM, Chelsea; and Westminster Hospital, 369 Fulham Rd, SW10 9NH, UK.
- Tuberculosis infection control in hospitals has received renewed interest after decades of low prominence following the occurrence of multiply drug-resistant strains in populations of patients with immune systems affected by HIV. This paper examines the history of tuberculosis infection control in hospitals and how re
- Human anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDS.
- J Immunol Methods. 1999 Dec 10;231(1-2):223-38. Unique Identifier : AIDSLINE MED/20115642
- Marasco WA; LaVecchio J; Winkler A; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, 44 Binney Street, Boston, MA; 02115, USA. wayne_marasco@dfci.harvard.edu
- The early successes of highly active anti-retroviral therapies (HAART) for the treatment of HIV-1-infection and AIDS have raised the question as to whether there is a legitimate role for gene therapy in the treatment of this chronic infectious disease. However, in many patients the profound suppression of viral replic
- The immunomodulatory role of CD4-positive cytotoxic T-lymphocytes in health and disease.
- Int Rev Immunol. 1999;18(5-6):449-64. Unique Identifier : AIDSLINE MED/20136450
- Hahn S; Erb P; Institute for Medical Microbiology, University of Basel,; Switzerland.
- Among the CD4-positive (CD4+) T-lymphocytes a population exists which expresses cytolytic activity. These killer cells belong to the T helper type 1 (Th1) subset and if activated, express Fas-ligand (FasL) which induces apoptosis in Fas-positive target cells. The major targets of these CD4+ cytotoxic T-lymphocytes (
- Limited access to antiretroviral therapy for intravenous drug users in Europe [letter]
- J Epidemiol Community Health. 1999 Nov;53(11):739. Unique Identifier : AIDSLINE MED/20121559
- Schrooten W; Fleerackers Y; Andraghetti R; Dreezen C; Finazzi R; Caldeira L; Colebunders R
- Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus.
- J Gen Virol. 2000 Feb;81 Pt 2:407-14. Unique Identifier : AIDSLINE MED/20112902
- Jones CM; Cose SC; McNally JM; Jennings SR; Heath WR; Carbone FR; Department of Pathology, Monash Medical School, Commercial Road,; Prahran, Victoria 3181, Australia.
- We have shown that C57BL/6-derived CD8(+) CTL specific for an immunodominant herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) determinant express a highly conserved Vbeta10/junctional sequence combination. This extreme T cell receptor beta-chain bias can be used to track the activation of gB-specific CTL in lym
- Changes of leukocyte phenotype and function in the broncho-alveolar lavage fluid of pigs infected with porcine reproductive and respiratory syndrome virus: a role for CD8(+) cells.
- J Gen Virol. 2000 Feb;81 Pt 2:497-505. Unique Identifier : AIDSLINE MED/20112912
- Samsom JN; de Bruin TG; Voermans JJ; Meulenberg JJ; Pol JM; Bianchi AT; Department of Mammalian Virology, Institute for Animal Science; and Health, NL-8200 AB Lelystad, The Netherlands.; jn.samsom.cell@med.vu.nl
- Porcine reproductive and respiratory virus (PRRSV) primarily infects and destroys alveolar macrophages of the pig. The aim of the present study was to characterize the changes of leukocyte populations in the broncho-alveolar lavage fluid (BALF) of PRRSV-infected pigs. Piglets were inoculated intranasally with PRRSV st
- Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an in vivo model.
- J Gen Virol. 2000 Feb;81 Pt 2:507-13. Unique Identifier : AIDSLINE MED/20112913
- van Der Ende ME; Guillon C; Boers PH; Gruters RA; Racz P; Tenner-Racz K; Osterhaus AD; Schutten M; Department of Virology, Erasmus Medical Centre Rotterdam, Dr; Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
- The pathogenic properties of four primary human immunodeficiency virus type 2 (HIV-2) isolates and two primary HIV-2 biological clones were studied in an in vivo human-to-mouse chimeric model. The cell-associated viral load and the ability to reduce the severity of the induced graft-versus-host disease symptoms, the C
- Spread of distinct human immunodeficiency virus type 1 AG recombinant lineages in Africa.
- J Gen Virol. 2000 Feb;81 Pt 2:515-23. Unique Identifier : AIDSLINE MED/20112914
- Cornelissen M; van Den Burg R; Zorgdrager F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; University of Amsterdam, Meibergdreef 45, 1105BA Amsterdam, The; Netherlands. M.I.Cornelissen@amc.uva.nl
- To identify new subtype G human immunodeficiency virus type 1 (HIV-1) strains and AG recombinant forms, we collected 28 serum samples from immigrants to the Netherlands from 12 countries throughout Africa. Based on the gag sequences 22 isolates were identified as subtype A or
- Serinol-derived malyngamides from an Australian cyanobacterium.
- J Nat Prod. 1999 Dec;62(12):1698-9. Unique Identifier : AIDSLINE MED/20119915
- Wan F; Erickson KL; Carlson School of Chemistry, Clark University, Worcester,; Massachusetts 01610, USA.
- Serinol derivatives 4a and 4b were isolated from an Australian blue-green alga and characterized by spectroscopic means. Their absolute stereochemistry was established by chemical methods.
- Enhanced analytical sensitivity of a quantitative PCR for CMV using a modified nucleic-acid extraction procedure.
- J Clin Lab Anal. 2000;14(1):32-7. Unique Identifier : AIDSLINE MED/20112963
- Ferreira-Gonzalez A; Yanovich S; Langley MR; Weymouth LA; Wilkinson DS; Garrett CT; Department of Pathology, Medical College of Virginia Campus of; Virginia Commonwealth University, Richmond, Virginia 23298-0248,; USA. agonzalez@hsc.vcu.edu
- Accurate and rapid diagnosis of CMV disease in immunocompromised individuals remains a challenge. Quantitative polymerase chain reaction (QPCR) methods for detection of CMV in peripheral blood mononuclear cells (PBMC) have improved the positive and negative pred
- Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern.
- J Pathol. 1999 Jun;188(2):133-8. Unique Identifier : AIDSLINE MED/99359586
- Delecluse HJ; Hummel M; Marafioti T; Anagnostopoulos I; Stein H; Consultation and Reference Centre for Lymph Node Pathology and; Hematopathology, Institute of Pathology, Klinikum Benjamin; Franklin, Free Univerisity of Berlin, Germany.
- HIV-infected patients are at high risk of developing diffuse large B-cell lymphomas (DLBCL). It is currently unclear whether these lymphomas represent Epstein-Barr virus (EBV)-driven lymphoproliferations that develop in the setting of immunodeficiency, or whether these tumours are more closely related to the DLBCL see
- Cytokine secretion profiles of cloned T cells from human aortic atherosclerotic plaques.
- J Pathol. 1999 Jun;188(2):174-9. Unique Identifier : AIDSLINE MED/99359592
- de Boer OJ; van der Wal AC; Verhagen CE; Becker AE; Department of Cardiovascular Pathology, Academic Medical Center,; University of Amsterdam, Amsterdam, The Netherlands.
- T cells take part in the chronic inflammatory reaction in atherosclerotic plaques, but their specific role in atherosclerosis has not yet been fully elucidated. Nevertheless, one may anticipate that activated T cells may secrete cytokines capable of modulating the morphology and hence the stability of plaques by regul
- Antibody responses to a mucosally delivered HIV-1 gp120-derived C4/V3 peptide.
- J Reprod Immunol. 1999 Dec;45(2):99-112. Unique Identifier : AIDSLINE MED/20137444
- Zinckgraf JW; Winchell JM; Silbart LK; University of Connecticut, Department of Molecular and Cell; Biology, Storrs 06269, USA.
- T1-SP10MN(A) is a synthetic peptide containing a T-helper (Th), cytotoxic T cell (CTL) and a B-cell epitope derived from the HIV-1 gp120 envelope protein. This peptide can elicit both systemic and mucosal antibody responses following nasal immunization in various species. In the present study, three different mucosal
- Signaling activities of gammaherpesvirus membrane proteins.
- J Virol. 2000 Feb;74(4):1593-601. Unique Identifier : AIDSLINE MED/20111276
- Damania B; Choi JK; Jung JU; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.
- The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites.
- J Virol. 2000 Feb;74(4):1632-40. Unique Identifier : AIDSLINE MED/20111280
- Lim SP; Garzino-Demo A; Institute of Molecular and Cell Biology, Singapore 117609,; Singapore.
- It has been shown that the human immunodeficiency virus type 1 (HIV-1) Tat protein can specifically enhance expression and release of monocyte chemoattractant protein 1 (MCP-1) from human astrocytes. In this study, we show evidence that Tat-induced MCP-1 expression is mediated at the transcriptional level. Transient t
- Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus.
- J Virol. 2000 Feb;74(4):1648-57. Unique Identifier : AIDSLINE MED/20111282
- Giavedoni LD; Velasquillo MC; Parodi LM; Hubbard GB; Hodara VL; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78245, USA.; Lgiavedoni@icarus.sfbr.org
- We studied the innate and adaptive immune system of rhesus macaques infected with the virulent simian immunodeficiency virus isolate SIVmac251 by evaluating natural killer (NK) cell activity, cytokine levels in plasma, humoral and virological parameters, and changes in the activation markers CD25 (interleukin 2R :IL-2
- The central proline of an internal viral fusion peptide serves two important roles.
- J Virol. 2000 Feb;74(4):1686-93. Unique Identifier : AIDSLINE MED/20111286
- Delos SE; Gilbert JM; White JM; Department of Cell Biology, University of Virginia Health System,; School of Medicine, Charlottesville, Virginia 22908, USA.
- The fusion peptide of the avian sarcoma/leukosis virus (ASLV) envelope protein (Env) is internal, near the N terminus of its transmembrane (TM) subunit. As for most internal viral fusion peptides, there is a proline near the center of this sequence. Robson-Garnier structure predictions of the ASLV fusion peptide and i
- Multiepitopic B- and T-cell responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine.
- J Virol. 2000 Feb;74(4):1694-703. Unique Identifier : AIDSLINE MED/20111287
- Gah:ery-S:egard H; Pialoux G; Charmeteau B; Sermet S; Poncelet H; Raux M; Tartar A; L:evy JP; Gras-Masse H; Guillet JG; Laboratoire d'Immunologie des Pathologies Infectieuses et; Tumorales, INSERM Unit:e 445, Institut Cochin de G:en:etique; Mol:eculaire, Universit:e Ren:ee Descartes, H^opital Cochin,; 75014 Paris, France. gahery@icgm.cochin.inserm.fr
- We have attempted to develop an anti-human immunodeficiency virus (HIV) lipopeptide vaccine with several HIV-specific long peptides modified by C-terminal addition of a single palmitoyl chain. A mixture of six lipopeptides derived from regulatory or structural HIV-1 proteins (Nef, Gag, and Env) was prepared. A phase I
- Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques.
- J Virol. 2000 Feb;74(4):1704-11. Unique Identifier : AIDSLINE MED/20111288
- Rosenwirth B; ten Haaft P; Bogers WM; Nieuwenhuis IG; Niphuis H; Kuhn EM; Bischofberger N; Heeney JL; Uberla K; Departments of Virology and Animal Science, Biomedical Primate; Research Center, 2288 GJ Rijswijk, The Netherlands.
- A limited period of chemotherapy during primary immunodeficiency virus infection might provide a long-term clinical benefit even if treatment is initiated at a time point when virus is already detectable in plasma. To evaluate this strategy, we infected rhesus macaques with the pathogenic simian/human immunodeficiency
- Diminished human immunodeficiency virus type 1 reverse transcription and nuclear transport in primary macrophages arrested in early G(1) phase of the cell cycle.
- J Virol. 2000 Feb;74(4):1712-7. Unique Identifier : AIDSLINE MED/20111289
- Kootstra NA; Zwart BM; Schuitemaker H; Department of Clinical Viral-Immunology, Central Laboratory of; the Netherlands Red Cross Blood Transfusion Service, Academic; Medical Center, University of Amsterdam, 1066 CX Amsterdam, The; Netherlands.
- Previously, we and others have demonstrated that the process of reverse transcription of human immunodeficiency virus type 1 (HIV-1) is disturbed in nondividing macrophages and quiescent T lymphocytes. Here we analyzed which phase of the cell cycle in macrophages is crucial for early steps in the HIV-1 replication cyc
- Multiple integrations of human foamy virus in persistently infected human erythroleukemia cells.
- J Virol. 2000 Feb;74(4):1718-26. Unique Identifier : AIDSLINE MED/20111290
- Meiering CD; Comstock KE; Linial ML; Division of Basic Sciences, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.
- Foamy viruses are complex retroviruses whose replication strategy resembles that of conventional retroviruses. However, foamy virus replication also resembles that of hepadnaviruses in many respects. Because hepadnaviruses replicate in an integrase-independent manner, we were interested in investigating the characteri
- Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA.
- J Virol. 2000 Feb;74(4):1767-74. Unique Identifier : AIDSLINE MED/20111296
- Van Rompay KK; Miller MD; Marthas ML; Margot NA; Dailey PJ; Canfield DR; Tarara RP; Cherrington JM; Aguirre NL; Bischofberger N; Pedersen NC; California Regional Primate Research Center, University of; California, Davis, California 95616, USA. kkvanrompay@ucdavis.edu
- Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study pathogenesis and to develop intervention strategies aimed at preventing infection or delaying disease progression. In previous studies, we demonstrated that 9-:2-(R)-(phosphonomethoxy)propyladeni
- Abundant defective viral particles budding from microglia in the course of retroviral spongiform encephalopathy.
- J Virol. 2000 Feb;74(4):1775-80. Unique Identifier : AIDSLINE MED/20111297
- Hansen R; Czub S; Werder E; Herold J; Gosztonyi G; Gelderblom H; Schimmer S; Mazgareanu S; ter Meulen V; Czub M; Institut f]ur Virologie und Immunbiologie, Universit]at; W]urzburg, D-97078 W]urzburg, Germany.
- A pathogenetic hallmark of retroviral neurodegeneration is the affinity of neurovirulent retroviruses for microglia cells, while degenerating neurons are excluded from retroviral infections. Microglia isolated ex vivo from rats peripherally infected with a neurovirulent retrovirus released abundant mature type C virio
- Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha.
- J Virol. 2000 Feb;74(4):1787-93. Unique Identifier : AIDSLINE MED/20111299
- Maeda Y; Foda M; Matsushita S; Harada S; Department of Biodefence and Medical Virology, School of; Medicine, Kumamoto University, Kumamoto, Japan.; ymaeda@kaiju.medic.kumamoto-u.ac.jp
- To determine whether C-C chemokines play an important role in the phenotype switch of human immunodeficiency virus (HIV) from CCR5 to CXCR4 usage during the course of an infection in vivo, macrophage inflammatory protein (MIP)-1alpha-resistant variants were isolated from CCR5-tropic (R5) HIV-1 in vitro. The selected v
- Expanded host cell tropism and cytopathic properties of feline immunodeficiency virus strain PPR subsequent to passage through interleukin-2-independent T cells.
- J Virol. 2000 Feb;74(4):1854-63. Unique Identifier : AIDSLINE MED/20111306
- Lerner DL; Elder JH; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.
- A cytopathic variant of feline immunodeficiency virus (FIV) strain PPR emerged after passage of wild-type virus on an interleukin-2-independent cell line. The virus, termed FIV-PPRglial, displayed a phenotype markedly different from the parental virus, including the ability to productively infect previously refractory
- The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cells.
- J Virol. 2000 Feb;74(4):1871-84. Unique Identifier : AIDSLINE MED/20111308
- Holtappels R; Thomas D; Podlech J; Geginat G; Steffens HP; Reddehase MJ; Institute for Virology, Johannes Gutenberg University, 55101; Mainz, Germany.
- Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation to cytolytic T lymphocytes (CTL). Specifically, the m152 gene product gp37/40 c
- Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120.
- J Virol. 2000 Feb;74(4):1948-60. Unique Identifier : AIDSLINE MED/20111316
- Moulard M; Lortat-Jacob H; Mondor I; Roca G; Wyatt R; Sodroski J; Zhao L; Olson W; Kwong PD; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, 13288 Marseille Cedex; 9, France.
- It is well established that the gp120 V3 loop of T-cell-line-adapted human immunodeficiency virus t