Therapeutic options or antiretroviral anarchy? NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Therapeutic options or antiretroviral anarchy?

J Int Assoc Physicians AIDS Care. 1999 Jan;5(1):10-30. Unique Identifier : AIDSLINE AIDS/20700020
Mascolini M

Abstract: The number of drug combinations being used to treat HIV infections may produce a public health nightmare by creating multidrug resistance. The issue of whether to use aggressive multidrug combinations early in the infectious cycle or whether to delay treatment as long as possible remains controversial and unresolved. The use of viral markers to track disease progression is discussed. Tables illustrate the relationships between CD4+ counts and opportunistic infections, disease progression, and long-term viral load reduction. The effectiveness of different drugs combinations is discussed. Results of various clinical trials are presented.

Keywords: NEWSLETTER ARTICLE Anti-HIV Agents/*THERAPEUTIC USE CD4 Lymphocyte Count Clinical Trials Congresses Disease Progression Drug Resistance, Microbial Drug Therapy, Combination Drugs, Investigational HIV Infections/*DRUG THERAPY/IMMUNOLOGY HIV-1/*DRUG EFFECTS Human Quality of Life RNA, Viral/BLOOD Scotland Time Factors Viral Load Virus Replication/DRUG EFFECTS

KWDnewsletterarticleanti-hivagents/KWDtherapeuticusecd4lymphocytecountclinicaltrialscongressesdiseaseprogressiondrugresistance,microbialdrugtherapy,combinationdrugs,investigationalhivinfections/KWDdrugtherapy/immunologyhiv-1/KWDdrugeffectshumanqualityofliferna,viral/bloodscotlandtimefactorsviralloadvirusreplication/drugeffects
000330
A0030929

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