Protease inhibitors at a glance.... NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Protease inhibitors at a glance....

Notes Undergr. 1998-99 Winter;(No 38):suppl 1-4. Unique Identifier : AIDSLINE AIDS/20700060


Abstract: Four protease inhibitors are compared: Saquinavir (Invirase, Fortovase), Indinavir (Crixivan), Ritonavir (Norvir), and Nelfinavir (Viracept). Key questions are answered on how dosages change when combined with nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and other protease inhibitors. Information on administration and storage and the impact of each drug on disease development are reviewed. Drug interactions between protease inhibitors and other HIV drugs and non-HIV medications are described. Side effects are also discussed. Pediatric use is addressed, including suggested dosages. Contact information for each manufacturer is provided, along with approximate annual price for treatment.


Keywords: NEWSLETTER ARTICLE Anti-HIV Agents/ADMINISTRATION & DOSAGE CD4 Lymphocyte Count/DRUG EFFECTS Disease Progression Drug Storage Drug Therapy, Combination HIV Infections/*DRUG THERAPY HIV Protease Inhibitors/*ADMINISTRATION & DOSAGE Human Reverse Transcriptase Inhibitors/ADMINISTRATION & DOSAGE

KWDnewsletterarticleanti-hivagents/administration&dosagecd4lymphocytecount/drugeffectsdiseaseprogressiondrugstoragedrugtherapy,combinationhivinfections/KWDdrugtherapyhivproteaseinhibitors/KWDadministration&dosagehumanreversetranscriptaseinhibitors/administration&dosage
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