Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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GMHC Treat Issues. 1999 Mar;13(3):2-5, 8. Unique Identifier : AIDSLINE AIDS/20700064
Grinberg L; Torres G
Abstract: HIV-associated lipodystrophy (HAL) is a side effect of successful viral suppression using highly active antiretroviral therapy (HAART). HAL manifests itself through a variety of changes in body composition and metabolism. Changes include unusual fat redistribution throughout the body and altered mechanics of fat metabolism that can result in high levels of triglycerides and cholesterol. Some of these symptoms were apparent before protease inhibitors (PIs) became widely available, and may be associated with other factors, including different antivirals and underlying metabolism problems. However, the majority of cases appear to be linked to PI use. There is no definitive test to diagnose HAL, and prevalence rates range from 3 percent to 80 percent. Results of several studies are presented, including some involving patients with lipodystrophy who have not taken PIs. The long-term effects of hyperlipidemia are described.
000330
A0030885
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