A placenta-derived suppressor factor with a T-cell bias [see comments]

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

A placenta-derived suppressor factor with a T-cell bias [see comments]

Am J Reprod Immunol. 1999 Oct;42(4):205-18. Unique Identifier : AIDSLINE MED/20046547
Raghupathy R; Khan SF; Syamasundar PV; Bansal P; Azizieh F; Department of Microbiology, Faculty of Medicine, Kuwait; University. raj@hsc.kuniv.edu.kw

Abstract: PROBLEM: Functional and mechanistic aspects of immunosuppression by murine placental supernatants (MPS) were investigated. METHOD OF STUDY: MPS and a low molecular weight fraction of the supernatant (MPSf) were tested for suppressive action on T-cell reactivity in vitro and in vivo, on B-cell responses and on T-cell activation events. RESULTS: MPS and MPSf suppress mitogen-induced proliferation and mixed lymphocyte reactions of human and murine lymphocytes, antigen-induced proliferation of T cells in vitro and in vivo, proliferation of CD8+ lymphocytes, proliferation induced by cross-linking of surface CD3 and the in vivo response of mice to allogeneic stimuli. MPSf affects cell cycling of activated T cells and blocks interleukin (IL)-2 production. MPSf does not affect antibody production or the induction of MHC class II expression on B cells. CONCLUSIONS: MPSf is a potent inhibitor of T-cell responses in vitro and in vivo, with no demonstrable effect on B-cell function.

Keywords: JOURNAL ARTICLE Animal Antigens, CD3/IMMUNOLOGY B-Lymphocytes/CYTOLOGY/IMMUNOLOGY Cell Division/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Female Human Interferon Type II/PHARMACOLOGY Interleukin-2/ANTAGONISTS & INHIB/SECRETION Interleukin-4/PHARMACOLOGY K562 Cells Lymphocyte Transformation/IMMUNOLOGY Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Ovalbumin/IMMUNOLOGY/PHARMACOLOGY Pregnancy Pregnancy Proteins/ISOLATION & PURIF/*PHYSIOLOGY Receptors, Interleukin-2/ANTAGONISTS & INHIB/BIOSYNTHESIS Support, Non-U.S. Gov't Suppressor Factors, Immunologic/ISOLATION & PURIF/*PHYSIOLOGY T-Lymphocytes/*IMMUNOLOGY

Comment in: Am J Reprod Immunol 1999 Oct;42(4):199-204
000330
A0030880

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