Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):222-33. Unique Identifier : AIDSLINE MED/99266535
Wiseman MB; Sanchez JA; Buechel C; Mintun MA; Lopez OL; Milko D; Becker JT; Neuropsychology Research Program, University of Pittsburgh; Medical Center, Pennsylvania, USA.
Abstract: Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia, others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood flow was measured with PET imaging in HIV+ MCMD patients, HIV+ control subjects, and HIV- control subjects; analyses were performed by using statistical parametric mapping. Comparing a short-term memory task versus a rest state yielded activation in superior temporal cortex, postcentral gyrus, and cerebellum in all three subject groups. Comparing long- and short-term memory tasks yielded activation throughout the frontal cortex, including BA46. Activation in this area was reduced in the HIV+ control subjects and further reduced in the MCMD+ patients. Thus, brain activation associated with lower-level, automatic processing appears normal in HIV+ MCMD+ subjects, but activation associated with effortful retrieval and organizational processes is abnormal.
000330
A0030876
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