Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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J Gastroenterol. 1999 Dec;34(6):706-12. Unique Identifier : AIDSLINE MED/20053410
Kojima K; Nagayama R; Hirama S; Maeda T; Takikawa H; Miyake K; Yamanaka M; Shiga J; Department of Medicine, Teikyo University School of Medicine,; Tokyo, Japan.
Abstract: A 73-year-old man had fever, lymphadenopathy, granulocytopenia, thrombocytopenia, ascites, pleural effusion, liver injury, and an allergic-like skin rash. Autoantibodies, such as anti-nuclear antibody, were shown, and there were lactate dehydrogenase and alkaline phosphatase anomalies and platelet-associated IgG. His liver injury resembled that in autoimmune hepatitis. He was diagnosed with Epstein-Barr virus (EBV) infection associated with autoimmunization because of his clinical course, fluctuation of anti EBV antibodies and positive EBV genome in circulating lymphocytes and serum. This case suggests a close relationship between EBV infection and autoimmunization or autoimmune-like hepatitis.
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