2000

Ophthalmoplegia associated with the anti-Ri antibody.: J Neuroophthalmol. 1999 Dec;19(4):246-8. Unique Identifier : AIDSLINE MED/20074390; Ohmer R; Golnik KC; Richards AI; Kosmorsky GS; Cincinnati Eye Institute, Ohio, USA.; Anti-Ri antibodies most often occur in patients with breast cancer and typically are associated with the paraneoplastic syndrome of opsoclonus-myoclonus-ataxia. This study reports a patient with diplopia and ophthalmoplegia. She had anti-Ri antibodies, and despite an exhaustive search for malignancy at presentation, b
A dosimetric comparison of fan-beam intensity modulated radiotherapy with Gamma Knife stereotactic radiosurgery for treating intermediate intracranial lesions.: Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1325-30. Unique Identifier : AIDSLINE MED/20078490; Ma L; Xia P; Verhey LJ; Boyer AL; Department of Radiation Oncology, University of Maryland School; of Medicine, Baltimore 21201, USA. lma001@umaryland.edu; PURPOSE: To compare and evaluate treatment plans for the fan-beam intensity modulated radiotherapy and the Gamma Knife radiosurgery for treating medium-size intracranial lesions (range 4-25 cm3). METHODS AND MATERIALS: Treatment plans were developed for the Leksell Gamma Knife and a fan-beam inverse treatment planning
And will we ever cure AIDS? [news]: Time. 1999 Nov 8;154(19):84. Unique Identifier : AIDSLINE AHA/20078392; Ho D
Evaluation of HIV risk reduction intervention programs via latent growth model.: Eval Rev. 1999 Dec;23(6):648-62. Unique Identifier : AIDSLINE HTA/20058223; Wang J; Siegal HA; Falck RS; Carlson RG; Rahman A; Wright State University, USA.; The latent growth model (LGM) has drawn increasing attention in behavioral studies using longitudinal data. The LGM captures the level and trajectory of behavior change, variation in both the initial status and the trend of behavior change, as well as the time-ordered covariation between the initial status and change.
Ocular manifestations of HIV infection.: Curr Opin Ophthalmol. 1999 Dec;10(6):431-7. Unique Identifier : AIDSLINE HTA/20064414; Robinson MR; Ross ML; Whitcup SM; National Institutes of Health, National Eye Institute, Bethesda,; Maryland 20892-1863, USA. mrobin@Box-m.nih.gov; Ophthalmic abnormalities are common in HIV-infected patients. Serious ophthalmic diseases often result from opportunistic infections and can cause blindness in the absence of prompt diagnosis and therapy. We review recent advances in the diagnosis and management of HIV-associated ocular disease, including
Courage as a process of pushing beyond the struggle.: Qual Health Res. 1999 Nov;9(6):803-14. Unique Identifier : AIDSLINE HTA/20038784; Finfgeld DL; Sinclair School of Nursing, University of Missouri-Columbia, USA.; Six qualitative studies have been carried out to better understand courage among individuals who range in age from 14 to 94 years and are experiencing a variety of lingering threats to their well-being. The purpose of this meta-interpretation was to synthesize those works and further delineate an emergent formal theor
Social aspects of AIDS-related stigma in rural Uganda.: Health Place. 1997 Sep;3(3):143-7. Unique Identifier : AIDSLINE HTA/20038688; Muyinda H; Seeley J; Pickering H; Barton T; MRC/ODA Research Programme on AIDS in Uganda/Uganda Virus; Research Institute UVRI, Uganda.; In the process of collecting sexual behaviour data through in-depth interviews, 24 respondents offered information on stigma related to HIV-1 infection. Observations of social relations in public places and families of infected individuals were made. The findings suggest that although HIV/AIDS-related stigma has had a
Stigmatization, HIV/AIDS, and communities of color: exploring response to human service facilities.: Health Place. 1997 Sep;3(3):187-99. Unique Identifier : AIDSLINE HTA/20038693; Takahashi LM; Department of Urban and Regional Planning, School of Social; Ecology, University of California, Irvine 92697-7075, USA.; HIV and AIDS are rapidly becoming leading causes of death for men and women in large cities across the US. Epidemiological data indicate that persons of color in particular have been disproportionately affected by HIV/AIDS. The continuing growth in the incidence of HIV/AIDS among persons of color implies that human se
Cattle markets and local festivals: development of HIV/AIDS prevention interventions for specific risk situations in rural northeast Thailand.: Health Place. 1998 Sep;4(3):265-72. Unique Identifier : AIDSLINE HTA/20038726; Dole LR; Elkins DB; Boonjear K; Phiensrithom S; Maticka-Tyndale E; Multi-sectoral AIDS Prevention Strategy (MAPS), Northeast Centre; for AIDS Prevention and Care, Khon Kaen University, Thailand.; In rural Northeast Thailand , risk of sexual transmission of HIV is popularly perceived to be site-specific. Risk of HIV transmission in local scenarios like cattle markets and village festivals has not been adequately addressed. This paper assesses the use of community consultati
Health economics. Perfect combination.: Health Serv J. 1999 Oct 7;109(5675):26-7. Unique Identifier : AIDSLINE AHA/20064496; Youle M; Weston R; Trueman P; Swaden L; Leake H; Royal Free Hampstead Trust.; The assumption by some HAs that a shift from mono to combination drug therapies for HIV results in a proportional increase in drug expenditure, regardless of health gains, is misguided. Methods of calculating anti-HIV drug expenditure have failed to keep up with changing treatment regimes. There is an urgent need to c
Health status of Asian Americans: United States, 1992-94.: Adv Data. 1998 Aug 7;(298):1-16. Unique Identifier : AIDSLINE AHA/20064472; Kuo J; Porter K; OBJECTIVES: This report compares the health status of selected Asian national origin groups. METHODS: 1992-94 National Health Interview Survey (NHIS) data were analyzed for six Asian national origin groups (Chinese, Filipino, Asian Indian, Japanese, Vietnamese, and Korean), the Asian and Pacific Islander (API) populat
Paying for HIV/AIDS care at the turn of the century.: Am J Manag Care. 1999 Nov;5(11):1442. Unique Identifier : AIDSLINE AHA/20093894; O'Neill JF; HIV/AIDS Bureau, Health Resources and Services Administration, US; Department of Health and Human Services, Washington, DC, USA.
Developing a managed care delivery system for people with HIV/AIDS.: Am J Manag Care. 1999 Nov;5(11):1443-7. Unique Identifier : AIDSLINE AHA/20093895; Singer B; Gamliel S; Conviser R; Special Projects of National Significance Program, Office of; Science and Epidemiology, HIV/AIDS Bureau, US Department of; Health and Human Services, Washington, DC, USA.; Capitated managed care is now a significant part of the healthcare landscape in the United States . Consequently, states across the country are looking to it as a means of lowering their costs for Medicaid recipients. Implementing Medicaid managed care plans, however, requires considera
Comprehensive HIV services under a capitated reimbursement system: AIDS Healthcare Foundation.: Am J Manag Care. 1999 Nov;5(11):1450-6. Unique Identifier : AIDSLINE AHA/20093896; Reis PD; AIDS Healthcare Foundation, Los Angeles, CA 90028, USA.; The application of capitated managed care systems to Medicaid populations has increased as part of an effort to control healthcare costs. The difficulties of caring for people with HIV and AIDS in the Medicaid population is compounded by the issues of impoverishment and access to care. In this profile, we discuss the
Developing a managed care delivery system in New York State for Medicaid recipients with HIV.: Unique Identifier : AIDSLINE AHA/20093897; Feldman I; Cruz H; DeLorenzo J; Hidalgo J; Plavin H; Whitaker J; In the state of New York, models of care known as HIV Special Needs Plans (HIV SNPs) are being developed to meet the unique health and medical needs of Medicaid recipients with HIV.
Will drug resistance testing prove reliable enough to enhance HIV treatments?: Fac Notes. 1998 Nov-Dec;10(6):1-3. Unique Identifier : AIDSLINE AIDS/20700001; Murphy MJ; Drug resistance testing is important in evaluating and determining the effectiveness of HIV treatments. Genotypic tests evaluate genetic segments of the virus which correspond to resistance in particular drugs. Phenotypic tests assess the level of drugs needed to stop viral growth. The advantages and disadvantages of
Anti-discrimination laws protect both patients and HCWs.: Fac Notes. 1998 Nov-Dec;10(6):4-5. Unique Identifier : AIDSLINE AIDS/20700002; Murphy G; Murphy and McKnight, LLC, New Orleans.; Most courts have interpreted the Americans with Disabilities Act to include health care workers (HCWs) and others with HIV and AIDS as having a life impairment. Therefore, the Act protects these people from discrimination in the work place or from their medical care provider. Some job activities of HIV-positive employ
LaCARP seeks patients for study that will compare protease inhibitors.: Fac Notes. 1998 Nov-Dec;10(6):6. Unique Identifier : AIDSLINE AIDS/20700003; The Louisiana Community AIDS Research Program (LaCARP) is conducting a Protease Inhibitor Progression (PIP) study to determine how to lower the amount of HIV virus in the body. The trial is for HIV-positive patients, over 13 years of age, who have detectable viral loads, and who are on their initial course of protease
Patients sought for ACTU studies that will help answer questions about drugs.: Fac Notes. 1998 Nov-Dec;10(6):6. Unique Identifier : AIDSLINE AIDS/20700004; Two trials are being conducted by the Tulane-LSU Adult AIDS Clinical Trials Unit. ACTG 384 is for patients who have not had previous antiretroviral therapy. Study objectives address when to use protease inhibitor (PI) therapy, comparisons between different drug combinations, and long-term treatment. ACTG 398 is for pe
HOP wins 3-year grant to develop palliative care program.: Fac Notes. 1998 Nov-Dec;10(6):7-8. Unique Identifier : AIDSLINE AIDS/20700005; Kutzen H; Bennett M; Medical Center of Louisiana at New Orleans, HIV Outpatient; Program.; A grant from the Robert Wood Johnson Foundation to the HIV Outpatient Program of the Medical Center of Louisiana (HOP) will establish PalCare, a program to assist people with advanced HIV/AIDS by supplying palliative care services. Palliative care bridges the gap between traditional medical responses and hospice care
Case illustrates social work philosophy in a practical setting.: Fac Notes. 1998 Nov-Dec;10(6):9-10. Unique Identifier : AIDSLINE AIDS/20700006; Rankin D; Medical Center of Louisiana at New Orleans, HIV Outpatient; Program.; A case of an unemployed, addiction-prone, homeless man with HIV is profiled by a social worker. Discussing the man s circumstances enabled the man to explore issues about his treatment, including his ability to sustain a treatment regimen. Key issues of adherence to treatment, drug use, and confidentiality were consid
Now approved: Sustiva in combination offers patients a new first-line therapy.: Fac Notes. 1998 Nov-Dec;10(6):10. Unique Identifier : AIDSLINE AIDS/20700007; DuPont Pharmaceuticals Sustiva ( efavirenz ) was approved by the FDA as the first once-daily- dosing anti-HIV drug. Sustiva is a non-nucleoside revers
When caregivers can't agree on patient's competence.: Fac Notes. 1998 Nov-Dec;10(6):11-2. Unique Identifier : AIDSLINE AIDS/20700008; Dralle PW; LSU School of Medicine, Department of Psychiatry.; The issue of whether a specific patient is capable of making decisions regarding medical treatment is discussed. A psychiatrist deemed the patient incapable of making such decisions, however, an attending physician found the patient alert and agreed to honor a request for declining treatment and returning home. Such d
Understanding the reverse transcriptase inhibitors in HIV.: Fac Notes. 1998 Nov-Dec;10(6):13-5. Unique Identifier : AIDSLINE AIDS/20700009; Edmonds-Ogbuokiri J; Xavier University College of Pharmacy, Clinical Pharmacy.; Recent progress in treatment methods and medicines has made HIV more manageable. Factors contributing to this progress include advances in testing; the use and approval of protease inhibitors , non-nucleoside reverse transcriptase inhibitors, and other nucleosides; a
Ziagen (abacavir) approved: caution essential.: AIDS Treat News. 1999 Jan 8;(No 310):1, 3-6. Unique Identifier : AIDSLINE AIDS/20700010; James JS; The Food and Drug Administration ( FDA ) announced accelerated approval of Glaxo-Wellcome s abacavir ( Ziagen , 1592) in combination with other antiretrovirals.
1999: treatments, issues to watch.: AIDS Treat News. 1999 Jan 8;(No 310):1-3. Unique Identifier : AIDSLINE AIDS/20700011; James JS; Although the future of AIDS research is unclear, there are several treatment issues that need to be addressed. One drug that is in development is T-20, an antiviral which may be especially useful to those who have HIV-1 or who have already undergone HIV treatment. Research is also underway to study the body s ability
Improving drug development: exploratory clinical studies.: AIDS Treat News. 1999 Jan 8;(No 310):6. Unique Identifier : AIDSLINE AIDS/20700012; James JS; The problems that occurred during the development process of abacavir and the limitations of the data that resulted from that process can indicate ways to improve future research. For instance, researchers need to explore how to design a study with mo
Robert Gallo calls for new treatment approach.: AIDS Treat News. 1999 Jan 8;(No 310):6-7. Unique Identifier : AIDSLINE AIDS/20700013; Dr. Robert Gallo of the University of Maryland s Institute of Human Virology hopes to develop natural, patient-friendly, nontoxic treatments. It is hoped that these treatments will also be economically affordable for those who are unable to afford current treatments. The United Nations predicts that by 2015 there will
Writer needs help: legal defense fund.: AIDS Treat News. 1999 Jan 8;(No 310):8. Unique Identifier : AIDSLINE AIDS/20700014; James JS; A reporter who focuses on gay and lesbian youth issues and HIV/AIDS was arrested by the Sacramento Police Department during a sting operation to catch online pedophiles. Bruce Mirken was investigating a story about a gay teenager when he agreed to meet with a teenager that he had been communicating with online. The te
San Francisco: HMO coverage of acupuncture.: AIDS Treat News. 1999 Jan 8;(No 310):8. Unique Identifier : AIDSLINE AIDS/20700015; In 1995, the city of San Francisco passed legislation to provide its employees with insurance coverage for acupuncture and prescribed herbs. The goal was to encourage HMOs to incorporate traditional Chinese medicine into Western care. However, because of the way the law was implemented, the city ended up providing sep
New healthcare economics threaten HIV specialization, patient choice, & quality care.: AIDS Treat News. 1999 Jan 22;(No 311):1-4. Unique Identifier : AIDSLINE AIDS/20700016; James JS; Changes in managed care programs have forced many HIV physicians to spend a significant amount of time on non-HIV cases to support their practices. HIV patients are more negatively impacted than other high-cost patients, such as those with cancer or diabetes, because HIV is treated as part of primary care rather than
A visit to India: drug prices, research, & global access.: AIDS Treat News. 1999 Jan 22;(No 311):6-8. Unique Identifier : AIDSLINE AIDS/20700017; Scondras D; Drugs manufactured in India are 1,000 to 4,000 percent cheaper than the same product in U.S. pharmacies. Because of the possible effect on profits, drug companies are working hard to stop India and other nations that make inexpensive copies of lifesaving medicines. Most drugs are in
6 HIV riddles intersect at ICAAC.: J Int Assoc Physicians AIDS Care. 1998 Dec;4(12):4-27. Unique Identifier : AIDSLINE AIDS/20700018; Mascolini M; Recurring themes at the 38th ICAAC conference were new drugs, new toxicities, renewed immunity, resistance, adherence, and salvage therapy. Speedy and effective treatment for the newly infected was discussed, and diverging opinions were voiced on whether it is best to hit the disease hard and early or defer treatment
If silence = death, will numbers = answers?: J Int Assoc Physicians AIDS Care. 1998 Dec;4(12):28-30. Unique Identifier : AIDSLINE AIDS/20700019; Miskell B; The HIV Treatment Data Project (TDP) is an internet study that asks patients to self-report treatment, symptoms, and side effects. By tracking the experiences of many patients, TDP hopes to influence clinical strategies and minimize the need for lengthy clinical trials. Patients will report data on their clinical outc
Therapeutic options or antiretroviral anarchy?: J Int Assoc Physicians AIDS Care. 1999 Jan;5(1):10-30. Unique Identifier : AIDSLINE AIDS/20700020; Mascolini M; The number of drug combinations being used to treat HIV infections may produce a public health nightmare by creating multidrug resistance. The issue of whether to use aggressive multidrug combinations early in the infectious cycle or whether to delay treatment as long as possible remains controversial and unresolved.
Report on HIV/AIDS from IDSA: news from the mile high city.: Hopkins HIV Rep. 1999 Jan;11(1):1, 4, 7. Unique Identifier : AIDSLINE AIDS/20700021; Bartlett JG; HIV/AIDS was the subject of some of the presentations at the annual meeting of the Infectious Diseases Society of America (ISDA). The most significant presentation was by Dr. Anthony Fauci, who described the possibility of using IL-2 to purge latently-infected CD4 cell
The new drugs and how to use them.: Hopkins HIV Rep. 1999 Jan;11(1):2, 7. Unique Identifier : AIDSLINE AIDS/20700022; Gallant JE; More antiretroviral drugs are becoming available, increasing potential treatment regimens but also increasing the complexity of HIV treatment. The 4 newest of the 15 available antiretroviral agents are described: efavirenz (
Hepatitis C virus and HIV co-infection: a sleeping giant wakes.: Hopkins HIV Rep. 1999 Jan;11(1):3, 10-2. Unique Identifier : AIDSLINE AIDS/20700023; Sulkowski MS; Advances in HIV therapy have greatly reduced the incidence of HIV-related complications and mortality, but co-infection with hepatitis C (HCV) virus is becoming more visible. The two infections share transmission routes, with injection drug users and transfusion patients the most commonly infected. Although sexual tra
The restless tide: the HIV pandemic.: Hopkins HIV Rep. 1999 Jan;11(1):5, 9. Unique Identifier : AIDSLINE AIDS/20700024; Quinn TC; The second decade of the AIDS epidemic shows that the disease has proliferated at shocking speed, with an estimated 47 million people now infected. In spite of news that HIV medications have reduced the spread of infection in developed countries, the dramatic increases in Asia and sub-Saharan Africa show how dangerous
Product information.: Hopkins HIV Rep. 1999 Jan;11(1):6. Unique Identifier : AIDSLINE AIDS/20700025; Bartlett JG; Information is provided on efavirenz ( Sustiva , formerly DMP-266), including dosage information, resistance and clinical trial results, and pharmacology. Side effects are reviewed, as
Treatment of HIV related weight loss.: Hopkins HIV Rep. 1999 Jan;11(1):8-9. Unique Identifier : AIDSLINE AIDS/20700026; Cofrancesco J Jr; Weight loss is a significant problem with HIV and AIDS patients. The definition of wasting syndrome is provided. Men and women do not lose weight and body mass in the same way; the differences between the genders are reviewed. Treatment includes insuring an adequate oral intake of calories, correcting malabsorption pr
ACTG adult clinical trials unit at Johns Hopkins.: Hopkins HIV Rep. 1999 Jan;11(1):suppl 1-4. Unique Identifier : AIDSLINE AIDS/20700027; Brief descriptions are provided on clinical trials being conducted at Johns Hopkins. The drugs being studied, participation requirements, and time commitments are provided. The trials cover treatment of HIV-1 disease, complications related to HIV-1 infection, investigative services clinical trials, neurology and ocula
Valuable clinical tips from recent medical meetings.: Body Posit. 1999 Feb;12(2):13-4. Unique Identifier : AIDSLINE AIDS/20700028; Prescott LM; Recent medical meetings have included presentations on dietary, pharmacologic, and biotechnological studies that have immediate value in improving the life span or health of persons with HIV. Several of these advances are highlighted, such as famciclovir has been approved for herpes treatment in HIV-infected people an
Life beyond disability.: Body Posit. 1999 Feb;12(2):16-7. Unique Identifier : AIDSLINE AIDS/20700029; Larson P; Significant numbers of people with HIV are physically feeling better and would like to return to work but are concerned about losing their disability-related benefits. If they return to work and forfeit coverage, and then their health declines, they could be left with inadequate benefits. Issues to explore when making
Keep covered.: Body Posit. 1999 Feb;12(2):18-25. Unique Identifier : AIDSLINE AIDS/20700030; Medical insurance should be a primary consideration when a person with HIV is planning a return to the workforce. Regulatory issues are reviewed, emphasizing those from New York State. Medicare pitfalls and solutions are outlined, and AIDS Drug Assistance Plan (ADAP) eligibility is spelled out. The process for continu
The road back - one step at a time.: Body Posit. 1999 Feb;12(2):26-30. Unique Identifier : AIDSLINE AIDS/20700031; As people with HIV return to the work force in significant numbers, they can face a difficult transition. HIV symptoms, such as the inability to concentrate and intermittent fatigue, may interfere with work. HIV-positive people are advised to document their symptoms and learn as much as possible about their public and
State of emergency: HIV/AIDS among African Americans.: Body Posit. 1999 Feb;12(2):32-5. Unique Identifier : AIDSLINE AIDS/20700032; Maldonado M; HIV medical care has improved the health and the quality of life for many people with HIV, but African Americans are not experiencing the full benefits of these advances. AIDS is still the leading cause of death in African Americans between the ages of 25 and 44, and African American women account for 56 percent of th
CDC wants all States to add HIV to current AIDS surveillance programs. Centers for Disease Control and Prevention.: AIDS Alert. 1999 Feb;14(2):13-7. Unique Identifier : AIDSLINE AIDS/20700033; The Centers for Disease Control and Prevention (CDC) recommends that all States include HIV cases in their AIDS surveillance programs, which could add 200,000 people to the overall surveillance count. Thirty-two States already perform HIV surveillance, but three of them collect only pediatric information. There are no
CDC recommends new guidelines for HIV tracking. Centers for Disease Control and Prevention.: AIDS Alert. 1999 Feb;14(2):17-8. Unique Identifier : AIDSLINE AIDS/20700034; The Centers for Disease Control and Prevention (CDC) issued guidelines recommending that States conduct HIV infection case surveillance. The report includes revised case definitions for HIV in adults and children. The guidelines recommend that States collect standard sets of data for all cases of HIV and AIDS, includi
Testosterone therapy can improve mood, energy.: Unique Identifier : AIDSLINE AIDS/20700035; Columbia University researchers report significant improvements in mood, energy levels, libido, and muscle mass among HIV-positive men treated with testosterone therapy. The 8-week trial program was extended 4 additional weeks for persons who responded to therapy. The study had 112 male participants; no women were inc
Doctors should coordinate use of alternative therapies.: AIDS Alert. 1999 Feb;14(2):20-3. Unique Identifier : AIDSLINE AIDS/20700036; Nearly half of the U.S. population uses alternative medicine, and for people with HIV/AIDS, that figure may be up to 70 percent. Because of the potential effects of alternative treatments, physicians need to learn about these medicines and ask patients whether they are using them. One study that is addressed collected
East clashes with West in approach to HIV treatment.: AIDS Alert. 1999 Feb;14(2):22. Unique Identifier : AIDSLINE AIDS/20700037; Many alternative treatments for HIV disease have grown out of traditional Chinese or ayurvedic medicine. However, many practitioners of Western medicine regard alternative medicine with hostility. Whereas Western HIV treatments are aimed at fighting the virus, Chinese medicine focuses on bolstering the patient s immun
Study to track benefits of compliance intervention.: AIDS Alert. 1999 Feb;14(2):23-4. Unique Identifier : AIDSLINE AIDS/20700038; The main reason people fail their HIV treatment is lack of adherence to their prescribed regimen. Judith A. Erlen of the University of Pittsburgh School of Nursing will conduct a study on how habit training, problem solving, and intervention can affect patient adherence to protease inhibitor therapy. The study will be
People with HIV misunderstand viral-load tests.: AIDS Alert. 1999 Feb;14(2):suppl 1-2. Unique Identifier : AIDSLINE AIDS/20700039; Three-quarters of the HIV-positive people surveyed know their viral load counts according to a study conducted by Roche Diagnostics, but nearly half do not know how often testing should be done. Two-thirds of the patients surveyed also did not know when viral load tests should not be conducted, such as when the patien
HIV-negative moms may present higher transmission risk.: AIDS Alert. 1999 Feb;14(2):suppl 1-3. Unique Identifier : AIDSLINE AIDS/20700040; Although interventions aimed at preventing HIV transmission have focused on HIV-positive pregnant women, a larger group is also at risk: HIV-negative pregnant women. These women are at risk of becoming infected unknowingly and transmitting the disease to their infants. Forced sexual abstinence before and after deliver
'Ideal' microbicide may be best form of protection.: AIDS Alert. 1999 Feb;14(2):suppl 3-4. Unique Identifier : AIDSLINE AIDS/20700041; AIDS vaccines are a long way from being commercially available, however, microbicides may be a viable way to help prevent HIV transmission. In several observational studies microbicides have performed well, but in two controlled studies there was no decrease in infection rates. Nonoxynol-9 (N-9) may be able to kill pa
Dentist again loses in bias case; vows new appeal to Supreme Court.: AIDS Policy Law. 1999 Jan 22;14(1):1, 4-5. Unique Identifier : AIDSLINE AIDS/20700042; The U.S. Supreme Court upheld that the American with Disabilities Act (ADA) can protect a person with asymptomatic HIV but asked the First U.S. Circuit Court of Appeals to review part of its previous decision. Upon review, the U.S. Circuit Court upheld its earlier decision that dentist Randon Bragdon violated the ADA
Despite demand, employer interest in AIDS education wanes.: AIDS Policy Law. 1999 Jan 22;14(1):2. Unique Identifier : AIDSLINE AIDS/20700043; A survey of 2,000 adults, commissioned by the National AIDS Fund, found that AIDS remains a top health concern in the workplace, but fewer employers are offering workplace education programs. AIDS education reduces the risk of employer liability, avoids interruptions in productivity, and reduces anxiety about on-the-j
Homeless shelter agrees to educate clients about AIDS.: AIDS Policy Law. 1999 Jan 22;14(1):3. Unique Identifier : AIDSLINE AIDS/20700044; Rather than facing litigation for evicting a man with AIDS, a homeless shelter agreed to educate clients and staff about HIV. Patrick Biggers, a person with AIDS, was evicted from the Emmaus Center after staff and residents voiced fears that they would be exposed to infection. The American Civil Liberties Union (ACLU)
Judge orders mother to give baby AZT, stop breast-feeding.: AIDS Policy Law. 1999 Jan 22;14(1):5. Unique Identifier : AIDSLINE AIDS/20700045; A Lane County Circuit Court judge in Oregon ordered Kathleen Tyson to comply with her doctor s wishes to treat her newborn with AZT and to stop breast-feeding. The parents opposed the use of AZT because of possible side effects. The newborn has his mo
Hypodermic needle, plus AIDS threat, equals deadly weapon.: AIDS Policy Law. 1999 Jan 22;14(1):7. Unique Identifier : AIDSLINE AIDS/20700046; Robert Ainis was sentenced by the New Jersey Superior Court to 11 years in prison for robbing a convenience store and brandishing a hypodermic needle while threatening to inject the clerk with AIDS. The New Jersey Superior Court ruled that using the needle in that manner, combined with the threat to deliberately infec
Guilty plea in needle case ends syringe swap program.: AIDS Policy Law. 1999 Jan 22;14(1):7. Unique Identifier : AIDSLINE AIDS/20700047; The executive director of a needle-exchange project received a 90-day suspended sentence on a charge of illegally distributing hypodermic syringes. In exchange for the suspended sentence, Diane McCague of the Chai Project had to shut down her program. Her sentence also included paying a fine of nearly $800, performing
HIV/AIDS and the States: a look at laws enacted in 1998.: AIDS Policy Law. 1999 Jan 22;14(1):8-13. Unique Identifier : AIDSLINE AIDS/20700048; This annual review of legislation tracks major developments in HIV policies at the State level. State legislatures appeared to have two primary objectives in 1998: surveillance programs and punishment for those who knowingly spread HIV. Legislative actions are arranged by topic, including criminal exposure and partner
Testing of defendant is valid even 18 months after the crime.: AIDS Policy Law. 1999 Jan 22;14(1):13. Unique Identifier : AIDSLINE AIDS/20700049; Eighteen months after his alleged sexual offenses against a child, David Isom was ordered by a Brevard County trial judge to be tested for HIV. The testing was requested by the guardians of the victim. On appeal, Isom argued that testing now would provide useless information since the law mandated testing to allow the
L.A. County settles suit by Healthcare Foundation.: AIDS Policy Law. 1999 Jan 22;14(1):14. Unique Identifier : AIDSLINE AIDS/20700050; The Los Angeles County Board of Supervisors agreed to pay a $1.2 million settlement to the AIDS Healthcare Foundation, which charged that the county eliminated much of its funding in retribution for a series of protests criticizing county officials for cutting AIDS services funding. The foundation produced an audio re
For biting to be a felony, attacker must have HIV.: AIDS Policy Law. 1999 Jan 22;14(1):14. Unique Identifier : AIDSLINE AIDS/20700051; The Ohio Court of Appeals vacated the conviction of Constance Reif-Hill, who resisted routine blood testing on admission to a psychiatric hospital. The blood test was required to determine her alcohol and medication levels. Reif-Hill became highly agitated, telling staff that she had AIDS. She then bit one employee, p
HIV transfusion suit killed because blood was the patient's.: AIDS Policy Law. 1999 Jan 22;14(1):15. Unique Identifier : AIDSLINE AIDS/20700052; A New York Supreme Court ruled against a patient who claimed to have received HIV from a blood transfusion. The patient, identified as John Doe, donated four units of his own blood prior to cardiac surgery. Doe argued that he was given blood from someone else and then contracted HIV. All of the evidence showed that th
HIV reporting.: AIDS Policy Law. 1999 Jan 22;14(1):16. Unique Identifier : AIDSLINE AIDS/20700053; The California debate over HIV surveillance resumed with the introduction of a bill to use coded identifiers to track HIV infections. Bill 103 is similar to another bill vetoed by Gov. Pete Wilson in 1998. Wilson favors name-based reporting. The new governor, Democrat Gray Davis, appears more open to using unique iden
Life sentence.: AIDS Policy Law. 1999 Jan 22;14(1):16. Unique Identifier : AIDSLINE AIDS/20700054; Brian Stewart, convicted of first-degree assault for injecting his infant son with HIV-contaminated blood, has been sentenced to life in prison. Stewart, who will be eligible for parole in 15 years, plans to appeal the verdict. It was alleged that Stewart injected the boy to avoid child support payments. His son is no
Lawsuit settled.: AIDS Policy Law. 1999 Jan 22;14(1):16. Unique Identifier : AIDSLINE AIDS/20700055; Charlene Riling settled her lawsuit against a physician whom she claimed misdiagnosed her with AIDS. Riling went to the doctor with a low-grade fever, swollen glands, headaches, coughing, and digestive problems, and told the doctor she had previously received a positive HIV test result. The doctor did not confirm the
Glutamania-is there anything Glutamine doesn't do?: Notes Undergr. 1998-99 Winter;(No 38):1-4. Unique Identifier : AIDSLINE AIDS/20700056; Szalavitz M; Glutamine, a nutritional supplement, has been acclaimed to stop diarrhea and wasting, enhance muscularity, promote immune cell growth, and possibly slow HIV progression. It is most commonly used with anti-oxidants, which help relieve oxidative stress and neutralize chemicals that are built up in the bloodstream as a r
Anti-HIV medications + street drugs: some cocktails don't mix.: Notes Undergr. 1998-99 Winter;(No 38):1, 4-5. Unique Identifier : AIDSLINE AIDS/20700057; The combination of HIV medications and street drugs not only taxes the liver and/or kidneys, but can be lethal. Several potential interactions are discussed. One dangerous combination is when ecstasy (X, MDMA) is taken with any protease inhibitor or non-nucleoside reverse transcriptase inhibitor. Sedatives, barbiturat
Pain medications and recovery.: Notes Undergr. 1998-99 Winter;(No 38):6-7. Unique Identifier : AIDSLINE AIDS/20700058; Szalavitz M; Pain medication is an important part of healing, and concerns about relapsing into addiction can be destructive. Patients should inform their doctor about previous addictions and can investigate other avenues of pain management, such as acupuncture or massage. If these methods do not prove effective, patients should f
Hepatitis treatment update: new approvals, not much news.: Notes Undergr. 1998-99 Winter;(No 38):7-8. Unique Identifier : AIDSLINE AIDS/20700059; Learned J; Thymosin-Alpha-1 (Zadaxin) is a synthetic hormone that has been studied as a treatment for HIV, hepatitis B, and hepatitis C. Recently approved in Mexico as a booster for the flu vaccine, it was also approved in nine other countries for flu, hepatitis B, and hepatitis C. The demand
Protease inhibitors at a glance....: Notes Undergr. 1998-99 Winter;(No 38):suppl 1-4. Unique Identifier : AIDSLINE AIDS/20700060; Four protease inhibitors are compared: Saquinavir ( Invirase , Fortovase), Indinavir ( Crixivan
Retroviruses Conference, Chicago 1999.: AIDS Treat News. 1999 Feb 12;(No 312):1-2. Unique Identifier : AIDSLINE AIDS/20700061; James JS; The 6th Conference on Retroviruses and Opportunistic Infections was the largest AIDS scientific meeting of 1999. It provided an overview of the current state of basic and applied medical science related to the disease. Promising drugs are in development, and HIV-specific immunity remains an important area of study. Ot
Restoring HIV-specific immunity.: AIDS Treat News. 1999 Feb 12;(No 312):2-6. Unique Identifier : AIDSLINE AIDS/20700062; James JS; When HIV is controlled with antiretrovirals, immunity to other infections often returns. Sometimes patients can stop prophylactic treatment, and sometimes opportunistic infections can clear up without treatment. However, immunity to HIV itself does not return, or returns very slowly, even when HIV has been suppressed
Global patent police block cost-reduction efforts.: GMHC Treat Issues. 1999 Mar;13(3):1-2. Unique Identifier : AIDSLINE AIDS/20700063; Kasper T; Sub-Saharan Africa has been seriously affected by the AIDS epidemic, with infection rates exceeding 30 percent in some areas. Unfortunately, most of the drugs used for treatment in the United States are not available in other countries because of high costs. The high costs can be attri
HAL in 2001: a fat oddity.: GMHC Treat Issues. 1999 Mar;13(3):2-5, 8. Unique Identifier : AIDSLINE AIDS/20700064; Grinberg L; Torres G; HIV-associated lipodystrophy (HAL) is a side effect of successful viral suppression using highly active antiretroviral therapy (HAART). HAL manifests itself through a variety of changes in body composition and metabolism. Changes include unusual fat redistribution throughout the body and altered mechanics of fat metab
Pregnant women's urine analyzed for antiviral agents.: GMHC Treat Issues. 1999 Mar;13(3):6-7. Unique Identifier : AIDSLINE AIDS/20700065; Commercial preparations of human chorionic gonadotropin (HCG) inhibit growth of Kaposi s sarcoma (KS) in laboratory animals and test tube cultures. HCG is made from the urine of pregnant women, who secrete large quantities of the hormone during their first trimester. The actual mechanisms at work with HCG are still un
Fat, sugar and drugs on the French Riviera.: GMHC Treat Issues. 1999 Mar;13(3):9-11. Unique Identifier : AIDSLINE AIDS/20700066; Lands L; The 3rd International Conference on Nutrition and HIV Infection emphasized lipodystrophy and the metabolic implications of highly active antiretroviral therapy (HAART). Several presentations challenged the idea that protease inhibitors alone caused lipodystrophy. Th
Protease inhibitors, sexual dysfunction and Viagra.: GMHC Treat Issues. 1999 Mar;13(3):12. Unique Identifier : AIDSLINE AIDS/20700067; Gilden D; Impotence is often associated with protease inhibitor use, but much of the medical press ignored this issue until Spanish doctors described sexual difficulties following protease inhibitor therapy in 14 of 260 patients. Causes of sexual dysfunction in HIV-infected men are difficult to isolate but may also be traced to
Peripheral facial paralysis revealing HIV infection [letter]: Unique Identifier : AIDSLINE MED/20062240; Vanpee D; Gillet JB; Laloux P
A placenta-derived suppressor factor with a T-cell bias [see comments]: Am J Reprod Immunol. 1999 Oct;42(4):205-18. Unique Identifier : AIDSLINE MED/20046547; Raghupathy R; Khan SF; Syamasundar PV; Bansal P; Azizieh F; Department of Microbiology, Faculty of Medicine, Kuwait; University. raj@hsc.kuniv.edu.kw; PROBLEM: Functional and mechanistic aspects of immunosuppression by murine placental supernatants (MPS) were investigated. METHOD OF STUDY: MPS and a low molecular weight fraction of the supernatant (MPSf) were tested for suppressive action on T-cell reactivity in vitro and in vivo, on B-cell responses and on T-cell a
Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells.: Am J Reprod Immunol. 1999 Oct;42(4):240-5. Unique Identifier : AIDSLINE MED/20046551; Saito S; Tsukaguchi N; Hasegawa T; Michimata T; Tsuda H; Narita N; Department of Obstetrics and Gynecology, Toyama Medical and; Pharmaceutical University, Japan. s30saito@m.s.toyama-mpu.ac.jp; PROBLEM: To examine whether normal pregnancy involves type 2 T-helper (Th2) immune condition or not. METHOD OF STUDY: We measured the percentage of Th0, Th1, and Th2 and the Th1/Th2 cell ratios of human peripheral blood and endometrial T cells using flow cytometry, which can analyze both the surface marker CD3, and in
Membrane destabilization assay based on potassium release from liposomes.: Biochim Biophys Acta. 1999 Nov 9;1461(1):103-12. Unique Identifier : AIDSLINE MED/20025447; Silberstein A; Mirzabekov T; Anderson WF; Rozenberg Y; Gene Therapy Laboratories, School of Medicine, University of; Southern California, 1441 EastLake Ave., Room 610, Los Angeles,; CA, USA.; Inorganic ions are highly suitable markers for monitoring release of the inner content of liposomes. In the present study, a potassium (K(+)) selective electrode was used to evaluate the rate of K(+) release from large unilamellar vesicles (LUV). The developed method is highly sensitive, reproducible and inexpensive.
Regulation of HIV-1 transcription.: Gene Expr. 1999;8(2):67-84. Unique Identifier : AIDSLINE MED/20017958; Roebuck KA; Saifuddin M; Department of Immunology/Microbiology, Rush Presbyterian St.; Luke's Medical Center, Chicago, IL 60612, USA. kroebuck@rush.edu; Human immunodeficiency virus type-1 (HIV-1) is a highly pathogenic lentivirus that requires transcription of its provirus genome for completion of the viral life cycle and the production of progeny virions. Since the first genetic analysis of HIV-1 in 1985, much has been learned about the transcriptional regulation of
Patterns of relative cerebral blood flow in minor cognitive motor disorder in human immunodeficiency virus infection.: J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):222-33. Unique Identifier : AIDSLINE MED/99266535; Wiseman MB; Sanchez JA; Buechel C; Mintun MA; Lopez OL; Milko D; Becker JT; Neuropsychology Research Program, University of Pittsburgh; Medical Center, Pennsylvania, USA.; Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia , others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood
The role of precise conceptualization in the treatment of a complicated HIV-1-infected neuropsychiatric patient.: J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):234-40. Unique Identifier : AIDSLINE MED/99266536; LoPiccolo CJ; Goodkin K; Department of Psychiatry and Behavioral Sciences, University of; Miami School of Medicine, Florida 33136, USA.; Patients infected with human immunodeficiency virus, type 1, may present with neuropsychiatric manifestations across all stages of disease. Frequently, these patients may present with more than one neuropsychiatric disorder concomitantly. The case presented highlights the utility of detailed clinical observation, care
Spatial working memory in asymptomatic HIV-infected subjects.: J Neuropsychiatry Clin Neurosci. 1999 Summer;11(3):387-91. Unique Identifier : AIDSLINE MED/99368889; Grassi B; Garghentini G; Campana A; Grassi E; Bertelli S; Cinque P; Epifani M; Lazzarin A; Scarone S; Psychiatric Branch, Centro San Luigi, University of Milan Medical; School, Italy.; Many clinical and research findings converge to indicate that frontal lobe, basal ganglia, and related neuronal connections are primarily involved in human immunodeficiency virus (HIV) infection; frontal lobe, mainly the prefrontal cortex, has a specialized role in working memory processes. This study focused on neuro
Induction of IgE responses using a recombinant mosquito salivary allergen rAed a 2 without adjuvant in mice.: Int Arch Allergy Immunol. 1999 Oct;120(2):135-40. Unique Identifier : AIDSLINE MED/20014682; Wang H; Mao X; Simons FE; Peng Z; Section of Allergy and Clinical Immunology, Department of; Pediatrics and Child Health, Winnipeg, Canada.; BACKGROUND: Reactions to mosquito bites are a global problem. Several salivary proteins from Aedes (Ae.) aegypti, the most common mosquito species, have been cloned and expressed. Plasmid DNA vaccination has been shown to be effective in the downregulation of IgE responses. To investigate the in vivo antigenicity of t
Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance.: Brain Res Cogn Brain Res. 1999 Oct 25;8(3):185-201. Unique Identifier : AIDSLINE MED/20025662; Weed MR; Taffe MA; Polis I; Roberts AC; Robbins TW; Koob GF; Bloom FE; Gold LH; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA, USA.; A computerized behavioral battery based upon human neuropsychological tests (CANTAB, CeNeS, Cambridge, UK) has been developed to assess cognitive behaviors of rhesus monkeys. Monkeys reliably performed multiple tasks, providing long-term assessment of changes in a number of behaviors for a given animal. The overall go
Health situation in former communist bloc is dire, says Unicef [news]: BMJ. 1999 Nov 20;319(7221):1324. Unique Identifier : AIDSLINE MED/20035246; Ciment J
Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly.: J Gastroenterol. 1999 Dec;34(6):706-12. Unique Identifier : AIDSLINE MED/20053410; Kojima K; Nagayama R; Hirama S; Maeda T; Takikawa H; Miyake K; Yamanaka M; Shiga J; Department of Medicine, Teikyo University School of Medicine,; Tokyo, Japan.; A 73-year-old man had fever, lymphadenopathy, granulocytopenia, thrombocytopenia, ascites, pleural effusion, liver injury, and an allergic-like skin rash. Autoantibodies, such as anti-nuclear antibody, were shown, and there were lactate dehydrogenase and alkaline phosphatase anomalies and platelet-associated IgG. His
Preliminary comparison of precursor scans and liquid chromatography-tandem mass spectrometry on a hybrid quadrupole time-of-flight mass spectrometer.: J Chromatogr A. 1999 Aug 27;854(1-2):119-30. Unique Identifier : AIDSLINE MED/99426221; Borchers C; Parker CE; Deterding LJ; Tomer KB; Laboratory of Structural Biology, National Institute of; Environmental Health Sciences, National Institutes of Health,; Research Triangle Park, NC 27709, USA.; Recent mass spectrometry instrumentation developments include the appearance of novel hybrid tandem instrumentation, Q-TOF, consisting of a quadrupole mass analyzer (MS1) and a time-of-flight (TOF) analyzer. The TOF analyzer is not scanned, but collects all fragment ions entering the analyzer at a given time. Thus, th
Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.: Curr Biol. 1999 Aug 26;9(16):861-8. Unique Identifier : AIDSLINE +; Barbulescu M; Turner G; Seaman MI; Deinard AS; Kidd KK; Lenz J; Department of Molecular Genetics, Albert Einstein College of; Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.; BACKGROUND: Endogenous retroviruses contribute to the evolution of the host genome and can be associated with disease. Human endogenous retrovirus K (HERV-K) is related to the mouse mammary tumor virus and is present in the genomes of humans, apes and cercopithecoids (Old World monkeys). It is unknown how long ago in
AIDS-related services and training in outpatient mental health care agencies in New York.: Psychiatr Serv. 1999 Sep;50(9):1225-8. Unique Identifier : AIDSLINE MED/99406027; McKinnon K; Cournos F; Herman R; Satriano J; Silver BJ; Puello I; Columbia University College of Physicians and Surgeons and the; Washington Heights Community Service of the New York State; Psychiatric Institute, New York 10032, USA. kmm49@columbia.edu; Directors of 471 outpatient mental health settings in New York State (82.1 percent of 574 settings located in counties with intermediate to high AIDS case rates) completed a survey about HIV and AIDS services, training needs, and barriers to care. Most of the sites served one to ten persons with HIV infection annually
Procoagulant expression in platelets and defects leading to clinical disorders.: Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2841-6. Unique Identifier : AIDSLINE MED/20060032; Solum NO; Research Institute for Internal Medicine, Rikshospitalet,; University of Oslo, Oslo, Norway. n.o.solum@rh.uio.no; Hemostasis is a result of interactions between fibrillar structures in the damaged vessel wall, soluble components in plasma, and cellular elements in blood represented mainly by platelets and platelet-derived material. During formation of a platelet plug at the damaged vessel wall, factors IXa and VIIIa form the ten
Cytokine and cytokine receptor concentrations in bone marrow supernatant from patients with HIV: correlation with hematologic parameters.: J Investig Med. 1999 Nov;47(9):477-83. Unique Identifier : AIDSLINE MED/20038517; Dallalio G; North M; McKenzie SW; Means RT Jr; Division of Hematology/Oncology, Ralph H. Johnson VA Medical; Center, Charleston SC, USA.; BACKGROUND: To determine the concentrations of tumor necrosis factor (TNF) alpha, soluble TNF receptors (sTNFR), interleukin (IL)-1 beta, gamma-interferon (IFN), macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES to which hematopoietic progenitors are exposed in vivo in HIV patients and the correlat
The hairpin ribozyme. Discovery, mechanism, and development for gene therapy.: Mol Biotechnol. 1999 Aug;12(1):117-29. Unique Identifier : AIDSLINE MED/20022426; Shippy R; Lockner R; Farnsworth M; Hampel A; Department of Biological Sciences, Northern Illinois University,; DeKalb 60115, USA.; The hairpin ribozyme is a member of a family of small RNA endonucleases, which includes hammer-head, human hepatitis delta virus, Neurospora VS, and the lead-dependent catalytic RNAs. All these catalytic RNAs reversibly cleave the phosphodiester bond of substrate RNA to generate 5 -hydroxyl and 2 ,3 -cyclic phosphate
Replacing competition with cooperation [editorial]: Nat Med. 1999 Dec;5(12):1329. Unique Identifier : AIDSLINE MED/20048122
Viral phenotype and CCR5 genotype [letter]: Nat Med. 1999 Dec;5(12):1330. Unique Identifier : AIDSLINE MED/20048125; Michael NL; Moore JP
Ancient HTLV-1 [news; comment]: Nat Med. 1999 Dec;5(12):1357. Unique Identifier : AIDSLINE MED/20048151; Novak K
A new HIV hideout [news]: Nat Med. 1999 Dec;5(12):1358. Unique Identifier : AIDSLINE MED/20048152; Mariani S
The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy.: Nat Med. 1999 Dec;5(12):1428-32. Unique Identifier : AIDSLINE MED/20048165; Li HC; Fujiyoshi T; Lou H; Yashiki S; Sonoda S; Cartier L; Nunez L; Munoz I; Horai S; Tajima K; Department of Virology, Faculty of Medicine, Kagoshima; University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.; The worldwide geographic and ethnic clustering of patients with diseases related to human T-cell lymphotropic virus type I (HTLV-I) may be explained by the natural history of HTLV-I infection. The genetic characteristics of indigenous people in the Andes are similar to those of the Japanese, and HTLV-I is generally de
Effective delivery of a lipophilic 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) into rat lymphoid tissues.: Exp Anim. 1999 Oct;48(4):241-6. Unique Identifier : AIDSLINE MED/20058532; Fujii Y; Akari H; Machida M; Kojima E; Murakami K; Yoshikawa Y; Iwakuni Research Laboratory, Nippon Paper Industries Co., Ltd.,; Yamaguchi, Japan.; Lipophilic 6-chloro-2 ,3 -dideoxyguanosine (6-Cl-ddG) was evaluated for its improved lymph node delivery by comparison with the parental nucleoside (ddG) in vitro and in vivo. The in vitro studies with rat plasma, lymph node homogenate and stomach content indicated that 6-Cl-ddG converted to ddG more effectively in th
Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease.: Diabetes Metab. 1999 Nov;25(5):383-92. Unique Identifier : AIDSLINE MED/20060445; Vigouroux C; Gharakhanian S; Salhi Y; Nguyen TH; Adda N; Rozenbaum W; Capeau J; Service de Biochimie, Hopital Rothschild, Paris, France.; capeau@st-antoine.inserm.fr; Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i
Tolerability of an extract of European mistletoe among immunocompromised and healthy individuals.: Unique Identifier : AIDSLINE MED/20018567; Gorter RW; van Wely M; Reif M; Stoss M; CONTEXT: European mistletoe (Viscum album L) has been used parenterally for more than 80 years as an anticancer medication with significant immunomodulating action. Since 1984, clinical experience with a Viscum album extract (Viscum album Quercus Frischsaft [Qu FrF]) among HIV-positive patients has suggested that it i
Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-hodgkin lymphoma.: Cancer. 1999 Nov 1;86(9):1840-7. Unique Identifier : AIDSLINE MED/20016314; Desai J; Mitnick RJ; Henry DH; Llena J; Sparano JA; Department of Radiation Oncology, Albert Einstein Comprehensive; Cancer Center, Montefiore Medical Center, Bronx, New York 10467,; USA.; BACKGROUND: Central nervous system involvement is a common manifestation of non-Hodgkin lymphoma (NHL) in human immunodeficiency virus (HIV)-infected individuals. The purpose of this study was to review the frequency and pattern of neurologic manifestation of lymphoma in a cohort of HIV-infected individuals with syste
Clinical efficacy of protease inhibitor based antiretroviral combination therapy--a prospective cohort study.: Eur J Med Res. 1999 Nov 22;4(11):449-55. Unique Identifier : AIDSLINE MED/20054892; Salzberger B; Rockstroh J; Wieland U; Franzen C; Schwenk A; Jutte A; Hegener P; Cornely O; Morchen C; Gaensicke T; Diehl V; Fatkenheuer G; Klinik I fur Innere Medizin, Universitatsklinik Koln, D-50924; Koln, Germany. bernd.salzberger@uni-koeln.de; OBJECTIVES: To analyze virological and clinical efficacy of protease inhibitor based antiretroviral regimens in a cohort of unselected HIV-infected patients. METHODS: Prospective analysis of all HIV-infected patients started on protease inhibitor therapy until August 31, 1997 in two outpatient clinics. Partial viral s
Antiretroviral therapy (ART) from a neurological point of view. German Neuro-AIDS study group (DNAA).: Eur J Med Res. 1999 Nov 22;4(11):456-62. Unique Identifier : AIDSLINE MED/20054893; Enzensberger W; von Giesen HJ; Neurologische Klinik der Heinrich-Heine-Universitat Dusseldorf,; Postfach 10 10 07, D-40001 Dusseldorf, Germany.; giesenhj@uni-duesseldorf.de.; Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART,
Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model.: Biol Blood Marrow Transplant. 1999;5(6):357-68. Unique Identifier : AIDSLINE MED/20061262; Ito M; Shizuru JA; Department of Medicine, Stanford University School of Medicine,; California 94305, USA.; It is known that an important curative benefit of allogeneic bone marrow transplantation (BAMT) in the treatment of hematolymphoid malignancies is a graft-vs.-tumor (GVT) effect. GVT activity has been attributed to mature immune cells contained within the graft because T-cell depletion of bone marrow results in increa
[Brain as an organ of immunity]: Zh Nevrol Psikhiatr Im S S Korsakova. 1999;99(9):62-5. Unique Identifier : AIDSLINE MED/20003453; Malashkhiia IuA; Nadareishvili ZG; Malashkhiia NIu; Malashkhiia VIu
Antibodies to the cytoplasm, cell membrane and nuclear membrane of malignant neoplasms in pooled normal human polyspecific immunoglobulin G.: Unique Identifier : AIDSLINE MED/20038240; Bar-Dayan Y; Barshack I; Blank M; Goldberg I; Levy Y; Kopolovic J; Fishman P; Shoenfeld Y; IVIg is a preparation of normal polyspecific IgG obtained from pooled plasma of a large number of healthy donors. IVIg treatment of patients with chronic lymphocytic leukemia induced a reduction
Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase BCL-2 expression.: Cell Death Differ. 1999 Oct;6(10):1002-11. Unique Identifier : AIDSLINE MED/20027821; Naora H; Gougeon ML; Unite d'Oncologie Virale and URA CNRS 1930, Departement SIDA et; Retrovirus Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris,; Cedex 15, France.; IL-15 shares many biological properties with IL-2 , a cytokine whose administration to HIV-infected individuals has been effective in enhancing depleted CD4 T lymphocyte numbers. The present study examined whether exogenous IL-15 could protect lymphocytes of HIV-infecte
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxy alcohols derived from alpha-amino acids.: Bioorg Med Chem Lett. 1999 Oct 18;9(20):3027-30. Unique Identifier : AIDSLINE MED/20035947; Benedetti F; Magnan M; Miertus S; Norbedo S; Parat D; Tossi A; Dipartimento di Scienze Chimiche, Biofisica e Chimica delle; Macromolecole, Universita di Trieste, Italy.; benedett@univ.trieste.it; (1R,2R,3S,4S)-4-Amino-3-hydroxy-1,2-epoxybutanes, accessible in four steps from L-aminoesters, react regio- and stereoselectively with diethyl aluminum cyanide to give (1R,2S,3S,4S)-4-amino-2,3-dihydroxynitriles. Hydrolysis yields hydroxylactones equivalent to 2,3-dihydroxy-4-aminoacids. The sequence provides a novel
The right to health fifty years on: still skeptical?: Health Hum Rights. 1999;4(1):6-25. Unique Identifier : AIDSLINE MED/20048204; Kirby M; The drafting of the Universal Declaration of Human Rights was a crucial step in the recognition of a legal right to health. Although the past 50 years have revealed weaknesses in the Declaration, it has been an important catalyst for social and legal change worldwide and for new thinking about public health. Recently,
Drug-induced lupus nephritis in HIV infection [letter]: Rheumatology (Oxford). 1999 Oct;38(10):1017-8. Unique Identifier : AIDSLINE MED/20006409; Smith PR; D'Cruz D; Raftery MJ; Dodd SM; Helbert M; Skinner CJ
Th1-type cytokine mRNA in rheumatoid arthritis mononuclear cells induced by streptococcal pyrogenic exotoxin A [letter]: Rheumatology (Oxford). 1999 Oct;38(10):1022-4. Unique Identifier : AIDSLINE MED/20006413; Szczepanska K; Chrzanowska-Lightowlers Z; Degnan BA; Diamond AG; Robson T; Ryzewska A; Goodacre JA
Frequency and predictors of medically attended injuries in HIV-infected children.: Clin Pediatr (Phila). 1999 Nov;38(11):625-35. Unique Identifier : AIDSLINE MED/20055093; Turner BJ; Cocroft J; Hauck WW; Schwarz DF; Casey R; Division of General Internal Medicine, Jefferson Medical College; of Thomas Jefferson University, Philadelphia, PA 19107-5083, USA.; The extent to which medically attended injuries complicate the clinical course of HIV-infected (HIV+) children is unknown. In a cohort of HIV+ children delivered from 1985 to 1990 and aged less than 60 months, we determined medically attended injuries per 100 child-years, Injury Severity Scores (ISS), and predictors o
Can HIV infection be prevented with a vaccine?: Drugs R D. 1999 Jun;1(6):431-40. Unique Identifier : AIDSLINE MED/20032510; Joy AK; Dale CJ; Kent SJ; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; The global human immunodeficiency virus type 1 (HIV-1) epidemic is devastating many communities and a well tolerated and effective vaccine is urgently required. Several lines of evident suggest that vaccine-induced protective immunity can be achieved. This evidence includes individuals shown to have natural immunity,
Prophylactic HIV vaccines. Summary and table.: Drugs R D. 1999 Jun;1(6):441-3. Unique Identifier : AIDSLINE MED/20032511; Wagstaff A; Brooke G; Adis International Limited, Auckland, New Zealand.f1
HIV gp120 vaccine (Chiron).: Drugs R D. 1999 Jun;1(6):445-7. Unique Identifier : AIDSLINE MED/20032512
HIV gp120 vaccine gene therapy (Wyeth-Lederle Vaccines-Malvern).: Drugs R D. 1999 Jun;1(6):448. Unique Identifier : AIDSLINE MED/20032513
HIV gp160 vaccine (Immuno AG).: Drugs R D. 1999 Jun;1(6):449-50. Unique Identifier : AIDSLINE MED/20032514
HIV gp160 vaccine gene therapy (Wyeth-Lederle Vaccines-Malvern).: Unique Identifier : AIDSLINE MED/20032515
HIV HGP-30W vaccine (Cel-Sci).: Drugs R D. 1999 Jun;1(6):453-5. Unique Identifier : AIDSLINE MED/20032516
HIV vaccine AIDSVAX.: Drugs R D. 1999 Jun;1(6):456-8. Unique Identifier : AIDSLINE MED/20032517
HIV vaccine vCP205. ALVAC-HIV vCP205, ALVAC vCP205.: Drugs R D. 1999 Jun;1(6):459-60. Unique Identifier : AIDSLINE MED/20032518
Immune reconstitution: is there a potential role for Filgrastim (r-metHuG-CSF).: J Hematother Stem Cell Res. 1999;8 Suppl 1:S1-2. Unique Identifier : AIDSLINE MED/20059194; Walker BD; Harvard Medical School, Charlestown, MA 02129, USA.
Clinical experience with Filgrastim in AIDS.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S17-9. Unique Identifier : AIDSLINE MED/20059197; Kuritzkes DR; University of Colorado Health Sciences Center, Denver 80262, USA.; Data have shown that neutropenia is a risk factor for severe bacterial infections. Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections. The incidence of Mycobacterium avium complex (MAC) infection in this setting was also evalu
Anti-inflammatory aspects of Filgrastim and impact on IL-2 release.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S21-2. Unique Identifier : AIDSLINE MED/20059198; Hartung T; University of Konstanz, Germany.; G-CSF has immunomodulatory effects of neutrophilic granulocytes and monocytes/macrophages. Two studies were done: one in normal volunteers and the other in HIV-infected patients plus their respective control donors to evaluate the effect of Filgrastim on cytokine responses. Filgrastim treatment of volunteers resulted
Neutropenia in patients with HIV infection: a case control study in a cohort of 1403 patients between 1982 and 1993.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S23-32. Unique Identifier : AIDSLINE MED/20059199; Hermans P; Sommereijns B; Van Cutsem N; Clumeck N; Division of Infectious Diseases, C.H.U. Saint-Pierre, Brussels,; Belgium.; The relationship between neutropenia and increased risks of severe infections in patients with HIV infection and the factors associated with neutropenia-induced infections was studied by a retrospective comparative study using matched case-control analysis. A database (1982-1993) of 1870 patients with HIV infection wa
Biopharmaceutical drug development: Filgrastim (r-metHuG-CSF) use in patients with HIV infection.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S3-8. Unique Identifier : AIDSLINE MED/20059195; Foote M; Welch W; Amgen Inc., Thousand Oaks, CA 91320-1799, USA.; Hematopoietic growth factors are well known to increase neutrophil counts and support the administration of myelotoxic and myelosuppressive therapies, especially chemotherapies. Filgrastim (r-metHuG-CSF) has been used in the setting of HIV disease to treat neutropenia and HIV-associated neutrophil defects. This articl
The use of Filgrastim in AIDS-related neutropenia.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S9-16. Unique Identifier : AIDSLINE MED/20059196; Welch W; Foote M; Amgen Inc., Thousand Oaks, CA 91320-1799, USA.; Neutropenic individuals are at high risk for bacterial and fungal infections. Filgrastim (r-metHuG-CSF, NEUPOGEN) has been shown to improve chemotherapy-induced neutropenia significantly. Because a high incidence of HIV-infected patients have neutropenia, often associated with myelosuppressive antiretroviral medicatio
Women with schizophrenia and co-occurring substance use disorders: an increased risk for violent victimization and HIV.: Community Ment Health J. 1999 Oct;35(5):401-19. Unique Identifier : AIDSLINE MED/20012607; Gearon JS; Bellack AS; University of Maryland-Baltimore, Department of Psychiatry,; 21201-1549, USA. jgearon@umaryland.edu; Women with serious mental illnesses are at risk for victimization and HIV. Schizophrenia related neurocognitive and social competency deficits exacerbated by the effects of substance abuse may make women with schizophrenia particularly vulnerable. Information processing deficits may impair the ability to identify situ
Motivations for condom use: do pregnancy prevention goals undermine disease prevention among heterosexual young adults?: Health Psychol. 1999 Sep;18(5):464-74. Unique Identifier : AIDSLINE MED/99446951; Cooper ML; Agocha VB; Powers AM; Department of Psychology, University of Missouri-Columbia 65211,; USA. cooperm@missouri.edu; Differences in motives for condom use and their implications for understanding frequency of use were investigated in a random, biracial (Black, White) sample of heterosexuals, aged 17 to 25 years (n = 902). Results indicated that sexually active young adults-regardless of race, age, gender, or relationship status-were
Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity.: Eur J Immunol. 1999 Nov;29(11):3562-70. Unique Identifier : AIDSLINE MED/20025992; Potsch C; Vohringer D; Pircher H; Institute of Medical Microbiology, Department of Immunology,; University of Freiburg, Freiburg, Germany.; Changes in the migration pattern of lymphocytes represent a key event in the evolution of an immune response since they enable lymphocytes to gain access to infected tissues. We studied the location of virus-specific CD8 T cells in various splenic compartments in response to infection with lymphocytic choriomeningitis
The increased CD38 expressed by lymphocytes infected with HIV-1 is a fully active NADase.: Eur J Immunol. 1999 Nov;29(11):3583-7. Unique Identifier : AIDSLINE MED/20025994; Bofill M; Parkhouse RM; Immunology Department Royal Free Hampstead NHS Trust, London, GB.; bofill@rfhsm.ac.uk; The NADase activity of the ectoenzyme CD38 on intact cells has been measured by a fluorometric assay using epsilon-NAD as a substrate. The enzyme activity was tested in the Daudi cell line, PHA-activated blasts and peripheral blood and tonsil lymphocytes from HIV-1-negative and -positive individuals. There was a direc
Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection.: Unique Identifier : AIDSLINE MED/20025999; Kropf P; Schopf LR; Chung CL; Xu D; Liew FY; Sypek JP; Muller I; In this study we characterized Th2 responses in the absence of IL-4. We show that ST2L, a stable Th2 marker, is expressed at similar levels in Leishmania major-infected IL-4-deficient
Selective pressure exerted by immunodominant HIV-1-specific cytotoxic T lymphocyte responses during primary infection drives genetic variation restricted to the cognate epitope.: Eur J Immunol. 1999 Nov;29(11):3629-35. Unique Identifier : AIDSLINE MED/20026000; Soudeyns H; Paolucci S; Chappey C; Daucher MB; Graziosi C; Vaccarezza M; Cohen OJ; Fauci AS; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Department of Internal; Medicine,Centre hospitalier universitaire vaudois, Lausanne,; Switzerland.; HIV-specific cytotoxic T lymphocytes (CTL) play a central role in the control of HIV-1 replication during primary infection. It has been hypothesized that the appearance of CTL escape mutants represents an important mechanism by which HIV-1 escapes the host cell-mediated immune response. However, evidences for a direc
Dual role of TNF-alpha in NK/LAK cell-mediated lysis of chronically HIV-infected U1 cells. Concomitant enhancement of HIV expression and sensitization of cell-mediated lysis.: Eur J Immunol. 1999 Nov;29(11):3654-62. Unique Identifier : AIDSLINE MED/20026003; Fortis C; Biswas P; Soldini L; Veglia F; Careddu AM; Delfanti F; Mantelli B; Murone M; Lazzarin A; Poli G; Laboratory of Clinical Immunology, Division of Infectious; Diseases, Centro San Luigi, San Raffaele Scientific Institute,; Milano, Italy. fortis.claudio@hsr.it; The U937-derived chronically HIV-infected U1 cell line and uninfected U937 cell clones were efficiently lysed by both unstimulated (NK) and IL-2-stimulated (lymphokine-activated killer; LAK) peripheral blood mononuclear cells (PBMC) of healthy HIV-seronegative donors. Pretreatment of target cells with IFN-gamma down-m
Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in a virus infection.: Eur J Immunol. 1999 Nov;29(11):3674-82. Unique Identifier : AIDSLINE MED/20026005; Gangappa S; Deshpande SP; Rouse BT; Department of Microbiology, College of Veterinary Medicine, The; University of Tennessee, Knoxville, USA.; Herpetic stromal keratitis (HSK) is an immunopathological lesion involving herpes simplex virus (HSV) infection and CD4(+) T cells of the Th1 phenotype, but the nature of the target antigens which drive HSK remains uncertain. In the present report we show that ovalbumin TCR-transgenic mice backcrossed to SCID mice una
IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection.: Unique Identifier : AIDSLINE MED/20026017; Wang S; Fan Y; Brunham RC; Yang X; Delayed-type hypersensitivity (DTH) has been demonstrated to be a Th1 type immune response which is important in the host defense against infection with intracellular bacteria, including Chlamydia. In the present study, we surprisingly observed that C. trachomatis mouse pneumonitis MoPn-infected IFN-gamma gene knockou
Protection against lethal toxoplasmosis in mice by an avirulent strain of Toxoplasma gondii: stimulation of IFN-gamma and TNF-alpha response.: Exp Parasitol. 1999 Dec;93(4):231-40. Unique Identifier : AIDSLINE MED/20070974; Haque S; Franck J; Dumon H; Kasper LH; Haque A; Department of Medicine and Microbiology, Dartmouth Medical School; Hanover, New Hampshire, 03755, USA. s.haque@medecine.univ-mrs.fr; In this study, we examined whether the PTN strain (isolated from an AIDS patient) of Toxoplasma gondii could induce cross-protection in mice against infection with a lethal dose of the PLK strain. Mice were first infected with tachyzoites (5 x 10(5)) of PTN and 5 days later challenged with PLK (1 x 10(5), LD(90)) para
Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides.: Unique Identifier : AIDSLINE MED/20036432; Hosoya T; Takeuchi H; Kanesaka Y; Yamakawa H; Miyano-Kurosaki N; Takai K; Yamamoto N; Takaku H; The inhibition of specific transcription regulatory proteins is a new approach to control gene expression. The transcriptional activities of DNA-binding proteins can be inhibited by the use of double-stranded oligonucleotides that compete for the binding to
National probability samples in studies of low-prevalence diseases. Part I: Perspectives and lessons from the HIV cost and services utilization study.: Health Serv Res. 1999 Dec;34(5 Pt 1):951-68. Unique Identifier : AIDSLINE MED/20057224; Shapiro MF; Berk ML; Berry SH; Emmons CA; Athey LA; Hsia DC; Leibowitz AA; Maida CA; Marcus M; Perlman JF; Schur CL; Schuster MA; Senterfitt JW; Bozzette SA; Department of Medicine, The University of California, Los; Angeles, USA.; OBJECTIVE: To examine the trade-offs inherent in selecting a sample design for a national study of care for an uncommon disease, and the adaptations, opportunities and costs associated with the choice of national probability sampling in a study of HIV/AIDS. SETTING: A consortium of public and private funders, research
National probability samples in studies of low-prevalence diseases. Part II: Designing and implementing the HIV cost and services utilization study sample.: Health Serv Res. 1999 Dec;34(5 Pt 1):969-92. Unique Identifier : AIDSLINE MED/20057225; Frankel MR; Shapiro MF; Duan N; Morton SC; Berry SH; Brown JA; Burnam MA; Cohn SE; Goldman DP; McCaffrey DF; Smith SM; St. Clair PA; Tebow JF; Bozzette SA; Baruch College, CUNY, USA.; OBJECTIVE: The design and implementation of a nationally representative probability sample of persons with a low-prevalence disease, HIV/AIDS. DATA SOURCES/STUDY SETTING: One of the most significant roadblocks to the generalizability of primary data collected about persons with a low-prevalence disease is the lack of
Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells.: J Biol Chem. 1999 Nov 26;274(48):33881-7. Unique Identifier : AIDSLINE MED/20036519; De Bleser PJ; Xu G; Rombouts K; Rogiers V; Geerts A; Laboratory for Cell Biology, Free University Brussels, B-1090; Brussels, Belgium.; Reactive oxygen species are implicated in the pathogenesis of several diseases, including Alzheimer s disease, multiple sclerosis, human immunodeficiency virus, and liver fibrosis. With respect to liver fibrosis, we have investigated differences in antioxidant enzymes expression in stellate cells (SCs) and parenchymal
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.: J Biol Chem. 1999 Nov 26;274(48):33913-20. Unique Identifier : AIDSLINE MED/20036523; Zhong M; Munzer JS; Basak A; Benjannet S; Mowla SJ; Decroly E; Chretien M; Seidah NG; Laboratory of Biochemical, Clinical Research Institute of; Montreal, University of Montreal, Montreal, Quebec H2W 1R7.; All proprotein convertases (PCs) of the subtilisin/kexin family contain an N-terminal prosegment that is presumed to act both as an intramolecular chaperone and an inhibitor of its parent enzyme. In this work, we examined inhibition by purified, recombinant bacterial prosegments of furin and PC7 on the in vitro proces
Self-association and domains of interactions of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by analytical ultracentrifugation and NMR experiments in trifluoroethanol/H(2)O mixtures.: Unique Identifier : AIDSLINE MED/20036559 P; Maroun RG
Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA.: J Biol Chem. 1999 Nov 26;274(48):34226-32. Unique Identifier : AIDSLINE MED/20036565; Kimzey AL; Dynan WS; Gene Regulation Program, Institute of Molecular Medicine and; Genetics, Medical College of Georgia, Augusta, Georgia 30912,; USA.; The human T-cell leukemia virus Tax protein directs binding of a host factor, cAMP response element binding protein, to an extended recognition sequence in the proviral promoter. Prior cross-linking experiments have revealed that Tax makes restricted contact with this DNA at two symmetric positions, 14 nucleotides apa
Functional disparity of distinct CD28 response elements toward mitogenic responses.: J Biol Chem. 1999 Nov 26;274(48):34369-74. Unique Identifier : AIDSLINE MED/20036584; Civil A; Rensink I; Aarden LA; Verweij CL; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Department of Autoimmune Diseases, 1066 CX Amsterdam,; The Netherlands.; Activation of T cells through the antigen-specific T-cell receptor in combination with a costimulatory signal results in efficient cytokine gene transcription. The CD28-induced signal represents a major costimulatory signal for T cells. A CD28 response element, named CD28RE, was first identified in the interleukin-2 (
The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.: J Biol Chem. 1999 Nov 26;274(48):34417-24. Unique Identifier : AIDSLINE MED/20036591; Li XH; Murphy KM; Palka KT; Surabhi RM; Gaynor RB; Division of Hematology-Oncology, Department of Medicine, Simmons; Cancer Center, University of Texas Southwestern Medical Center,; Dallas, Texas 75235-8594, USA.; Two cytokine-inducible kinases, IKKalpha and IKKbeta, are components of a 700-kDa kinase complex that specifically phosphorylates IkappaB. Phosphorylation of IkappaB by IKK leads to its ubiquitination and subsequent degradation, resulting in the nuclear translocation of NF-kappaB. The oncogenic protein Tax, encoded by
Enhancement of antibody responses by DNA immunization using expression vectors mediating efficient antigen secretion.: J Immunol Methods. 1999 Aug 31;228(1-2):121-30. Unique Identifier : AIDSLINE MED/20027004; Svanholm C; Bandholtz L; Lobell A; Wigzell H; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Box 280, 171 77, Stockholm, Sweden. cecilia.svanholm@mtc.ki.se; The immune responses elicited in mice, after intradermal (i.d.) immunization with plasmids encoding secreted or intracellular forms of HIV-1 nef, HIV-1 tat or C. pneumoniae omp2 proteins, respectively, were compared. To mediate secretion of these proteins the genes were fused to a heterologous signal sequence from mur
Generation and maintenance of autoantigen-specific CD8(+) T cell clones isolated from NOD mice.: J Immunol Methods. 1999 Aug 31;228(1-2):87-95. Unique Identifier : AIDSLINE MED/20027001; Bowie L; Tite J; Cooke A; Department of Medicine, Institute of Medical Sciences, University; of Aberdeen, Foresterhill, Aberdeen, UK. l.bowie@abdn.ac.uk; The non-obese diabetic (NOD) mouse develops insulin dependent diabetes mellitus (IDDM) spontaneously with a higher incidence in females than in males. There are many similarities to the human disease, making it an ideal model. Our group is examining the role that CD4(+) and CD8(+) T cells play in IDDM in the NOD mouse
Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1.: J Neurochem. 1999 Dec;73(6):2348-57. Unique Identifier : AIDSLINE MED/20047418; Bajetto A; Bonavia R; Barbero S; Piccioli P; Costa A; Florio T; Schettini G; Neuroscience Unit, Advanced Biotechnology Centre, Genova, Italy.; Chemokines are a family of proteins that chemoattract and activate cells by interacting with specific receptors on the surface of their targets. The chemokine stromal cell-derived factor 1, (SDF1), binds to the seven-transmembrane G protein-coupled CXCR4 receptor and acts to modulate cell migration, differentiation, a
Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: frequency and clinical significance.: J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):789-92. Unique Identifier : AIDSLINE MED/20036732; Bossolasco S; Marenzi R; Dahl H; Vago L; Terreni MR; Broccolo F; Lazzarin A; Linde A; Cinque P; Division of Infectious Diseases, San Raffaele Hospital, Via; Stamira d'Ancona 20, 20127 Milano, Italy.; The objective was to evaluate the frequency of human herpesvirus 6 (HHV-6) DNA detection in the CSF of patients infected with HIV and its relation to brain disease and systemic HHV-6 infection. Nested polymerase chain reaction (PCR) was used to analyse CSF samples from 365 consecutive HIV infected patients with neurol
The Outpatient Developmental Services Project: integration of pediatric psychology with primary medical care for children infected with HIV.: J Pediatr Psychol. 1999 Oct;24(5):381-91. Unique Identifier : AIDSLINE MED/20022101; Armstrong FD; Harris LL; Thompson W; Semrad JL; Jensen MM; Lee DY; Miloslavich K; Garcia A; University of Miami School of Medicine, USA.; darmstro@peds.med.miami.edu; OBJECTIVE: To present a model in which pediatric psychology services are programmatically integrated into the primary care of children seen in a special immunology program. The program centers around serial neurodevelopmental/neuropsychological evaluation of children infected with HIV. METHOD: We describe the populati
A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes.: J Mol Cell Cardiol. 1999 Nov;31(11):2037-47. Unique Identifier : AIDSLINE MED/20058559; Sakoda T; Kasahara N; Hamamori Y; Kedes L; Institute for Genetic Medicine, University of Southern California; School of Medicine, Los Angeles 90033, USA.; Human immunodeficiency virus (HIV, lentivirus) type-1 based vectors have a number of attractive features for gene therapy, including the ability to transduce non-dividing cells and long term transgene expression. We used a three-plasmid expression system to generate pseudotyped lentivirus-based vectors by transient tr
AIDS in paradise.: JAMA. 1999 Dec 15;282(23):2195-6. Unique Identifier : AIDSLINE MED/20071974; Koenig RE
AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study.: JAMA. 1999 Dec 15;282(23):2220-6. Unique Identifier : AIDSLINE MED/20071989; Ledergerber B; Egger M; Erard V; Weber R; Hirschel B; Furrer H; Battegay M; Vernazza P; Bernasconi E; Opravil M; Kaufmann D; Sudre P; Francioli P; Telenti A; Division of Infectious Diseases and Hospital Epidemiology,; University Hospital, Zurich, Switzerland.; CONTEXT: Acquired immunodeficiency syndrome-related opportunistic illnesses (Ols) continue to occur after initiation of potent antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection. Risk factors for clinical progression to Ols during potent therapy are not well defined. OBJECTIVE: To exa
Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial [see comments]: JAMA. 1999 Dec 22-29;282(24):2305-12. Unique Identifier : AIDSLINE MED/20077564; Kahn J; Lagakos S; Wulfsohn M; Cherng D; Miller M; Cherrington J; Hardy D; Beall G; Cooper R; Murphy R; Basgoz N; Ng E; Deeks S; Winslow D; Toole JJ; Coakley D; Positive Health Program University of California San Francisco,; San Francisco General Hospital, 94110, USA. jkahn@php.ucsf.edu; CONTEXT: Adefovir dipivoxil is a nucleotide analog that has demonstrated effective antiretroviral activity against human immunodeficiency virus (HIV) with once-daily administration. OBJECTIVE: To determine if adefovir confers antiretroviral or immunologic benefit when added to stable antiretroviral therapy. DESIGN: Mu
Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology.: JAMA. 1999 Dec 22-29;282(24):2321-7. Unique Identifier : AIDSLINE MED/20077566; Bifani PJ; Mathema B; Liu Z; Moghazeh SL; Shopsin B; Tempalski B; Driscol J; Frothingham R; Musser JM; Alcabes P; Kreiswirth BN; Public Health Research Institute Tuberculosis Center, Department; of Microbiology, New York University School of Medicine, NY; 10016, USA.; CONTEXT: Typing of Mycobacterium tuberculosis could provide a more sensitive means of identifying outbreaks than use of conventional surveillance techniques alone. Variants of the New York City W strain of M tuberculosis were identified in New Jersey. OBJECTIVE: To describe the spread of the W family of M tuberculosis
Adefovir for the treatment of HIV infection: if not now, when? [editorial; comment]: Unique Identifier : AIDSLINE MED/20077572; Mellors JW
Clinical course of HTLV-I-associated uveitis.: Unique Identifier : AIDSLINE MED/20046630; Nakao K; Ohba N; Nakagawa M; Osame M; PURPOSE: To define the long-term clinical course and visual outcome of human T-cell lymphotrophic virus type I (HTLV-I)-associated uveitis (HAU). METHODS: We reviewed the clinical data on 96 eyes of 70 patients, 26 men and 44 women, with HAU, with specific reference to recurrence of the disease and long-term visual ou
Antiviral agents for non-human immunodeficiency virus infections.: Mayo Clin Proc. 1999 Dec;74(12):1266-83. Unique Identifier : AIDSLINE MED/20058930; Keating MR; Division of Infectious Diseases and Internal Medicine, Mayo; Clinic Rochester, Minnesota 55905, USA.; Several new agents for treating viral infections have been developed in recent years. All available agents are virustatic, inhibiting specific steps in the process of viral replication. No agent is active against nonreplicating or latent viruses. Acyclovir is useful in the treat
Antiretrovirals.: Mayo Clin Proc. 1999 Dec;74(12):1284-301. Unique Identifier : AIDSLINE MED/20058931; Temesgen Z; Wright AJ; Mayo HIV Clinic, Division of Infectious Diseases and Internal; Medicine, Mayo Clinic Rochester, Minnesota, USA.; Deaths related to the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome and the incidence of opportunistic infections have been drastically decreased in the industrialized world. These reductions are mainly due to recent advances in the management of HIV infection, including the availabilit
Intestinal parasites of some diarrhoeic HIV-seropositive individuals in North Brazil, with particular reference to Isospora belli Wenyon, 1923 and Dientamoeba fragilis Jepps & Dobell, 1918.: Mem Inst Oswaldo Cruz. 1999 Sep-Oct;94(5):611-3. Unique Identifier : AIDSLINE MED/99395230; Lainson R; da Silva BA; Secao de Parasitologia, Instituto Evandro Chagas, Belem, PA,; 66090-000, Brasil.
Plasma platelet-activating factor acetylhydrolase activity in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.: Metabolism. 1999 Dec;48(12):1524-31. Unique Identifier : AIDSLINE MED/20066966; Khovidhunkit W; Memon RA; Shigenaga JK; Pang M; Schambelan M; Mulligan K; Feingold KR; Grunfeld C; Department of Veterans Affairs Medical Center, San Francisco, CA; 94121, USA.; Platelet-activating factor (PAF) acetylhydrolase (PAF-AH) catalyzes the hydrolysis of PAF, a mediator of inflammation, as well as other biologically active oxidized phospholipids. In humans, plasma PAF-AH activity is bound to low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Higher levels of plasma PAF
[Role of chorionic gonadotropin in the differentiation of thymocytes]: Ontogenez. 1999 Sep-Oct;30(5):341-5. Unique Identifier : AIDSLINE MED/20048307; Kuklina EM; Shirshev SV; Sharova NI; Iarilin AA; Institute of Ecology and Genetics of Microorganisms, Ural Branch; of the Russian Academy of Sciences, Perm, Russia.; The effects of chorionic gonadotropin, a basic hormone of pregnancy, on the differentiation of the human thymocytes were studied. The hormone does not affect the phenotype as determined by expression of the membrane molecules CD3, CD4, CD8 and functional activity of intrathymic pre-T-lymphocytes, but stimulates produc
Characterization of murine Th1 clones specific to egg antigen of Schistosoma japonicum and their interaction with cytokines.: Parasite Immunol. 1999 Nov;21(11):583-93. Unique Identifier : AIDSLINE MED/20051371; Yang JQ; Tasaka K; Chuang CK; Yoshikawa H; Nakajima Y; Department of Parasitology and Immunology, Yamanashi Medical; University, Tamaho, Yamanashi 409-3898, Japan.; T cell clones (B1, B21, B7, A25) specific to the soluble egg antigen (SEA) of Schistosoma japonicum were established from C3H/He mice immunized with SEA. These clones belonged to CD3+, CD4+ and CD8-Th1 cells, showing TCR-gamma delta-, TCR-alpha beta+ and Vbeta10b+. The molecular weights of target antigens recognized b
The distribution of RNA motifs in natural sequences.: Nucleic Acids Res. 1999 Nov 15;27(22):4457-67. Unique Identifier : AIDSLINE MED/20007891; Bourdeau V; Ferbeyre G; Pageau M; Paquin B; Cedergren R; Departement de Biochimie, Universite de Montreal, C.P. 6128,; Succursale Centre-Ville, Montreal, QC H3C 3J7, Canada.; Functional analysis of genome sequences has largely ignored RNA genes and their structures. We introduce here the notion of ribonomics to describe the search for the distribution of and eventually the determination of the physiological roles of these RNA structures found in the sequence databases. The utility of thi
Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia.: Planta Med. 1999 Oct;65(7):604-9. Unique Identifier : AIDSLINE MED/20042628; Berge JP; Bourgougnon N; Alban S; Pojer F; Billaudel S; Chermann JC; Robert JM; Franz G; Laboratoire de Biochimie et molecules Marines, IFREMER, Nantes,; France.; A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50% inhibitory concentration (EC50) of 14 micrograms/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation
The natural history of type 2 diabetes. Implications for clinical practice.: Prim Care. 1999 Dec;26(4):771-89. Unique Identifier : AIDSLINE MED/99453076; Ramlo-Halsted BA; Edelman SV; Division of Endocrinology and Metabolism, University of; California, San Diego, San Diego, California, USA.; This article reviews the natural history of type 2 diabetes and emphasizes that the disease is a continuum from impaired glucose tolerance and impaired fasting glucose to frank diabetes. Understanding this natural history aids the clinician in identifying those individuals most at risk for developing type 2 diabetes.
[The prattle with respect to the acquired immunodeficiency syndrome (letter; comment)]: Rev Clin Esp. 1999 Oct;199(10):695-6. Unique Identifier : AIDSLINE MED/20056641; Munoz Sanz A
[Chemokines, a new family of cytokines in inflammatory cell recruitment]: Rev Invest Clin. 1999 Jul-Aug;51(4):255-68. Unique Identifier : AIDSLINE MED/20013830; Martinez Martinez CM; Hernandez Pando R; Departamento de Patologia, Instituto Nacional de la Nutricion; Salvador Zubiran, Mexico, D.F.; Cell recruitment is a crucial event in the establishment of both acute and chronic inflammatory responses, including acute and delayed type hypersensitivity reactions. Among other significant factors like adhesion molecules, chemokines and its receptors are crucial elements that lead leukocyte migration to the tissues
Randomization-based methods for correcting for treatment changes: examples from the Concorde trial.: Stat Med. 1999 Oct 15;18(19):2617-34. Unique Identifier : AIDSLINE MED/99426978; White IR; Babiker AG; Walker S; Darbyshire JH; Medical Statistics Unit, London School of Hygiene and Tropical; Medicine, Keppel Street, London WC1E 7HT, U.K.; We develop analysis methods for clinical trials with time-to-event outcomes which correct for treatment changes during follow-up, yet are based on comparisons of randomized groups and not of selected groups. A causal model relating observed event times to event times that would have been observed under other treatment
Bayesian analysis of prevalence with covariates using simulation-based techniques: applications to HIV screening.: Stat Med. 1999 Nov 30;18(22):3059-73. Unique Identifier : AIDSLINE MED/20013163; Tu XM; Kowalski J; Jia G; Department of Biostatistics and Epidemiology, University of; Pennsylvania School of Medicine, 604 Blockley Hall, 423 Guardian; Drive, Philadelphia, PA 19104-6021, USA.; Ignoring the limited precision of medical diagnostic tests can incur serious bias in prevalence estimation. Conversely, treating the values of sensitivity and specificity as constants, as in most studies, inevitably underestimates the variability of prevalence estimates. Bayesian inference provides a natural framework
A non-parametric maximum likelihood estimator for bivariate interval censored data.: Stat Med. 1999 Nov 30;18(22):3089-100. Unique Identifier : AIDSLINE MED/20013165; Betensky RA; Finkelstein DM; Department of Biostatistics, Harvard School of Public Health, 655; Huntington Avenue, Boston, Massachusetts 02115, USA.; betensky@hsph.harvard.edu; We derive a non-parametric maximum likelihood estimator for bivariate interval censored data using standard techniques for constrained convex optimization. Our approach extends those taken for univariate interval censored data. We illustrate the estimator with bivariate data from an AIDS study. Copyright 1999 John Wil
An extension of Kendall's coefficient of concordance to bivariate interval censored data.: Stat Med. 1999 Nov 30;18(22):3101-9. Unique Identifier : AIDSLINE MED/20013166; Betensky RA; Finkelstein DM; Department of Biostatistics, Harvard School of Public Health, 655; Huntington Avenue, Boston, Massachusetts 02115, USA.; betensky@hsph.harvard.edu; Non-parametric tests of independence, as well as accompanying measures of association, are essential tools for the analysis of bivariate data. Such tests and measures have been developed for uncensored and right censored failure time data, but have not been developed for interval censored failure time data. Bivariate
The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo.: Science. 1999 Dec 10;286(5447):2159-62. Unique Identifier : AIDSLINE MED/20059937; Randolph DA; Huang G; Carruthers CJ; Bromley LE; Chaplin DD; Division of Allergy and Immunology, Department of Internal; Medicine, Center for Immunology, Washington University School of; Medicine. Howard Hughes Medical Institute, St. Louis, MO 63110,; USA.; Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naive and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones ne
Where do we stand with 5-fluorouracil?: Semin Oncol. 1999 Dec;26(6):589-605. Unique Identifier : AIDSLINE MED/20072268; Schmoll HJ; Buchele T; Grothey A; Dempke W; Department of Hematology/Oncology, Martin-Luther-University; Halle-Wittenberg, Halle, Germany.; For nearly four decades, 5-fluorouracil (5-FU) has been the mainstay of treatment for colorectal cancer. Due to the lack of other agents with significant activity, tremendous efforts have been undertaken to increase the efficacy of 5-FU by investigating alternative schedules of delivery and biomodulation. However, bol
Challenged by the small screen--responding to HIV-positive people on video in KwaZulu-Natal.: S Afr Med J. 1999 Oct;89(10):1060-6. Unique Identifier : AIDSLINE MED/20048758; Coleman R; Mngomezulu P
A quick, simple, and inexpensive method of surgical navigation for superficial intracranial targets.: Surg Neurol. 1999 Nov;52(5):530-1. Unique Identifier : AIDSLINE MED/20061224; Amar AP; Levy ML; Weiss MH; Department of Neurosurgery, University of Southern California,; Los Angeles, USA.
[HIV infection, gonorrhea and syphilis from Thailand to Norway]: Tidsskr Nor Laegeforen. 1999 Oct 30;119(26):3915-8. Unique Identifier : AIDSLINE MED/20060337; Aavitsland P; Nilsen O; Seksjon for forebyggende infeksjonsmedisin Statens institutt for; folkehelse, Oslo.; Thailand , a popular tourist destination for Norwegians, is experiencing an increasing epidemic of HIV infection. We used the Norwegian surveillance system for communicable diseases to assess the connections between the Norwegian and Thai epidemics. Before 1999, 1,869 cases of HIV
HIV-1 DNA vaccines and chemokines.: Vaccine. 1999 Oct 1;17 Suppl 2:S53-64. Unique Identifier : AIDSLINE MED/99436492; Boyer JD; Kim J; Ugen K; Cohen AD; Ahn L; Schumann K; Lacy K; Bagarazzi ML; Javadian A; Ciccarelli RB; Ginsberg RS; MacGregor RR; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.; DNA vaccines have a demonstrated ability to induce humoral and cellular immune responses in animal models and humans. The technology, although it dates back to the 1950 s, has had an insurgence of interest within the past few years following concurrent research papers. The basic technology is being applied broadly to
AIDS and HIV vaccines.: Vaccine. 1999 Oct 1;17 Suppl 2:S65-70. Unique Identifier : AIDSLINE MED/99436493; Klein M; Pasteur Merieux Connaught, 1541 Avenue Marcel Merieux, 69280,; Marcy l'Etoile, France.; In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite
Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidate.: Vaccine. 1999 Sep;18(3-4):259-67. Unique Identifier : AIDSLINE MED/99438260; Klinguer C; David D; Kouach M; Wieruszeski JM; Tartar A; Marzin D; Levy JP; Gras-Masse H; UMR 8525, IBL, Institut Pasteur de Lille, 1 rue Calmette, 59021,; Lille, France.; A multi-component vaccine has been defined, which contains six different synthetic 24- to 32-amino acid lipopeptides derived from the sequence of HIV-1 proteins. The physicochemical properties of the lipopeptide components were compatible with multi-dimensional analysis, using RP-HPLC, Edman sequencing, electrospray m
Accelerated clearance of SHIV in rhesus monkeys by virus-like particle vaccines is dependent on induction of neutralizing antibodies.: Vaccine. 1999 Sep;18(3-4):291-301. Unique Identifier : AIDSLINE MED/99438264; Notka F; Stahl-Hennig C; Dittmer U; Wolf H; Wagner R; Institute of Medical Microbiology, University of Regensburg,; Franz-Josef-Strauss Allee 11, D-93053, Regensburg, Germany.; Recombinant, insect cell derived SIV Pr56(gag) virus-like particles (VLPs) have been modified either by inserting HIV-1 Gp160 derived peptides into the Pr56(gag) precursor or by integrating the complete HIV-1 gp120 in the particle membrane. To investigate the protective efficacy of these particulate antigens, rhesus m
Specificity of anti-Nef antibodies produced in mice immunized with DNA encoding the HIV-1 nef gene product.: Vaccine. 1999 Sep;18(3-4):333-41. Unique Identifier : AIDSLINE MED/99438270; Moureau C; Moynier M; Kavsan V; Montagnier L; Bahraoui E; Laboratoire d'Immuno-virologie, Universite Paul Sabatier, 118; route de Narbonne, 31062, Toulouse, France.; Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo
Mapping the specificity of an anti-feline immunodeficiency virus monoclonal antibody using a filamentous phage displayed peptide library.: Vaccine. 1999 Sep;18(3-4):371-5. Unique Identifier : AIDSLINE MED/99438274; D'Mello F; Kairo SK; Howard CR; Partidos CD; Department of Pathology and Infectious Diseases, Royal Veterinary; College, Royal College Street, London, UK.; Recent developments in peptide technology enable the use of random peptide libraries for identifying linear amino acid sequences (mimotopes) which can mimic conformational epitopes without necessarily exhibiting amino acid sequence homology with the native linear sequence. In this study a 15-mer random peptide library
New developments in antiretroviral treatment.: Am Fam Physician. 1999 Dec;60(9):2663, 2666. Unique Identifier : AIDSLINE MED/20072013; Sadovsky R
Maternal HIV levels correlate with perinatal transmission.: Am Fam Physician. 1999 Dec;60(9):2684, 2687. Unique Identifier : AIDSLINE MED/20072014; Kirchner JT
The Village AIDS Day Treatment Program: a model of interdisciplinary and interdependent care.: Am J Occup Ther. 1999 Nov-Dec;53(6):561-5. Unique Identifier : AIDSLINE MED/20045385; Murphy N; Messina W; Getter E; Gutterman L; Martin T; Rincon P; Zimmerman J; Village AIDS Day Treatment Program, New York, New York 10011,; USA.; This article describes the Village AIDS Day Treatment Program, a program for people living with HIV/AIDS that provides health care by using a full range of interdependent services. Opened in 1988, this program was the first of its kind in the country. It has provided leadership in developing a model of care that addre
Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis.: Am J Pathol. 1999 Dec;155(6):1915-27. Unique Identifier : AIDSLINE MED/20063638; Dallasta LM; Pisarov LA; Esplen JE; Werley JV; Moses AV; Nelson JA; Achim CL; Department of Pathology, Division of Neuropathology, University; of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; dallasta@np.awing.upmc.edu; The blood-brain barrier (BBB) plays a critical role in regulating cell trafficking through the central nervous system (CNS) due to several unique anatomical features, including the presence of interendothelial tight junctions that form impermeable seals between the cells. Previous studies have demonstrated BBB perturb
Sexual and drug-use risk factors for HIV and STDs: a comparison of women with and without bisexual experiences.: Am J Public Health. 1999 Dec;89(12):1841-6. Unique Identifier : AIDSLINE MED/20056691; Gonzales V; Washienko KM; Krone MR; Chapman LI; Arredondo EM; Huckeba HJ; Downer A; Center for Health Education and Research, University of; Washington, Seattle 98104, USA. gonza@u.washington.edu; OBJECTIVES: This study was done to compare risk factors for HIV/STDs in women who reported having had sex with both men and women and women who reported having had sex with men only. METHODS: Female participants in a multisite, randomized HIV/STD prevention study in the Seattle area reported both having had sex with a
Cigarette smoking among gay and bisexual men.: Am J Public Health. 1999 Dec;89(12):1875-8. Unique Identifier : AIDSLINE MED/20056701; Stall RD; Greenwood GL; Acree M; Paul J; Coates TJ; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA. rstall@psg.ucsf.edu; OBJECTIVES: This study measured the prevalence of cigarette smoking among gay men and identified associations with smoking. METHODS: Household-based (n = 696) and bar-based (n = 1897) sampling procedures yielded 2593 gay male participants from Portland, Ore, and Tucson, Ariz, in the spring of 1992. RESULTS: Forty-eigh
Detection of DNA hybridization using the TISPR-1 surface plasmon resonance biosensor.: Anal Biochem. 1999 Oct 1;274(1):7-17. Unique Identifier : AIDSLINE MED/99459221; Kukanskis K; Elkind J; Melendez J; Murphy T; Miller G; Garner H; Joint Program of Biomedical Engineering, University of Texas; Southwestern Medical Center at Dallas, Dallas, Texas, USA.; Biotinylated oligonucleotide probes were immobilized to the gold sensor surface of the TISPR-1 miniature integrated surface plasmon resonance liquid sensor system for the purpose of detecting specific DNA hybridization. The immobilization of the oligonucleotide capture probes was carried out through streptavidin-bioti
The synthetic CD4 exocyclic CDR3.AME(82-89) inhibits NF-kappaB nuclear translocation, HIV-1 promoter activation, and viral gene expression.: DNA Cell Biol. 1999 Nov;18(11):819-28. Unique Identifier : AIDSLINE MED/20060844; Roland J; Berezov A; Greene MI; Murali R; Piatier-Tonneau D; Devaux C; Briant L; Laboratoire Infections Retrovirales et Signalisation Cellulaire,; CNRS EP J0004, Institut de Biologie, Montpellier, France.; We have previously shown that the synthetic aromatically modified exocyclic (AME) analog (CDR3.AME(82-89), derived from the CDR3 (residues 82-89) region of CD4 domain 1, inhibits replication of human immunodeficiency virus type 1 (HIV-1) in infected cells. In this work, we investigated the mechanism by which this inhi
Nurses with blood-borne pathogens and the moral responsibilities of nurse regulating authorities.: Aust J Adv Nurs. 1999 Mar-May;16(3):7-13. Unique Identifier : AIDSLINE MED/99354720; Johnstone MJ; Crock E; Department of Nursing and Public Health, Faculty of Biomedical; and Health Sciences and Nursing, RMIT University, Victoria,; Australia.; This paper examines, for consideration by nurses and nurse regulating authorities (NRA), certain ethical and practice issues concerning registered/enrolled nurses with blood-borne pathogens (BBPs), such as Human Immunodeficiency Virus and Hepatitis Viruses. Under existing legislation, the identity and infectious statu
Interleukin-10: The missing link in asthma regulation? [comment]: Am J Respir Cell Mol Biol. 1999 Nov;21(5):562-3. Unique Identifier : AIDSLINE MED/20007693; Umetsu DT; DeKruyff RH; Department of Pediatrics, Center for Asthma and Allergic; Diseases, and Stanford University, Stanford, California; 34305-5208, USA.
HIV complicates the management of oncological emergencies: a case involving the superior vena cava syndrome.: Clin Oncol (R Coll Radiol). 1999;11(5):355-7. Unique Identifier : AIDSLINE MED/20059414; Videtic GM; Kocha WI; Malthaner RA; London Regional Cancer Centre, University of Western Ontario,; London, Ontario, Canada. gvidetic@lrcc.on.ca; An association exists between human immunodeficiency virus (HIV) and an increased incidence of lung cancer. Superior vena cava syndrome (SVCS) is an oncological emergency seen in the presence of chest tumours. We report on an otherwise well HIV-positive male who presented with SVCS due to lung cancer. He was commenced
Socio-demographic characteristics and sexual behaviour of adolescents attending the STC, UCH, Ibadan: a 5 year review.: West Afr J Med. 1999 Jul-Sep;18(3):165-9. Unique Identifier : AIDSLINE MED/20060735; Fawole OI; Ajayi IO; Babalola TD; Oni AA; Asuzu MC; Department of Preventive and Social Medicine, University College; Hospital, Ibadan, Nigeria.; As a continuation of the on-going efforts to prevent and control the spread of sexually transmitted diseases (STDs) and the Acquired Immunodeficiency Syndrome (AIDS) in adolescents, this retrospective clinic-based study identifies the socio- demographic characteristics, describes the sexual practices, identifies the c
Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress [see comments]: Br J Nutr. 1999 May;81(5):405-11. Unique Identifier : AIDSLINE MED/20082075; Malpuech-Brugere C; Nowacki W; Gueux E; Kuryszko J; Rock E; Rayssiguier Y; Mazur A; Centre de Recherche en Nutrition Humaine d'Auvergne, Unite; Maladies Metaboliques et Micronutriments, INRA,; St-Genes-Champanelle, France.; Experimental Mg deficiency leads to alterations in the immune response. Reduction of thymus weight and histological changes were previously observed in Mg-deficient rats after several weeks on a deficient diet, suggesting that functions of this immune organ may be affected by Mg deficiency. More recently, changes in t
Synthesis of biotinylated glycoconjugates and their use in a novel ELISA for direct comparison of HIV-1 Gp120 recognition of GalCer and related carbohydrate analogues.: Bioconjug Chem. 1999 Nov-Dec;10(6):1021-31. Unique Identifier : AIDSLINE MED/20031552; McReynolds KD; Hadd MJ; Gervay-Hague J; The University of Arizona, Department of Chemistry, Tucson, AZ; 85721, USA.; As part of our program directed toward the design and synthesis of high-affinity ligands for the GalCer-binding site on the HIV cell surface glycoprotein, gp120, we required a reliable method for qualitatively assessing relative binding affinities for related analogues. Due to the hydrophilic nature of these synthetic
Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases.: Hum Gene Ther. 1999 Dec 10;10(18):2961-72. Unique Identifier : AIDSLINE MED/20075748; Dow SW; Elmslie RE; Fradkin LG; Liggitt DH; Heath TD; Willson AP; Potter TA; Department of Medicine, National Jewish Medical and Research; Center, Denver, CO 80206-2761, USA. dows@njc.org; Local expression of cytokine genes by ex vivo transfection or intratumoral gene delivery can control the growth of cutaneous tumors. However, control of tumor metastases by conventional nonviral gene therapy approaches is more difficult. Intravenous injection of lipid-DNA complexes containing noncoding plasmid DNA can
Tumor necrosis factor alpha and gamma interferon are required for the development of protective immunity to secondary Corynebacterium pseudotuberculosis infection in mice.: J Vet Med Sci. 1999 Nov;61(11):1203-8. Unique Identifier : AIDSLINE MED/20059150; Lan DT; Makino S; Shirahata T; Yamada M; Nakane A; Department of Veterinary Microbiology, Obihiro University of; Agriculture and Veterinary Medicine, Hokkaido, Japan.; The production and role of endogenous cytokines during the course of secondary Corynebacterium (C.) pseudotuberculosis infection were investigated in mice. When immunized mice were challenged on day 28 after primary infection, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were found to appea
[The prevalence of infection by the hepatitis B, C and human immunodeficiency viruses in drug users]: Aten Primaria. 1999 Oct 15;24(6):368-71. Unique Identifier : AIDSLINE MED/20064026; Jimenez Fabrega X; Carballo Almeida A; Batalla Martinez C; Comin Bertran E; Cuenca Oliva AM; Ezpeleta Garcia A; Lopez Gonzalo E; Parellada Esquius N; ABS Dr. Pujol i Capsada, El Prat de Llobregat, Barcelona.; OBJECTIVE: Estimate the prevalence of the hepatitis B (HBV) infection, hepatitis C (HCV) and human immunodeficiency virus (HIV) and its coexistence in intravenous drug users, in order to start afterwards a vaccination and sanitary training programmes. PATIENTS AND METHODS: Intravenous drug users attended in a health c
Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation.: Blood. 1999 Dec 1;94(11):3847-54. Unique Identifier : AIDSLINE MED/20042219; Kawakami A; Nakashima T; Sakai H; Urayama S; Yamasaki S; Hida A; Tsuboi M; Nakamura H; Ida H; Migita K; Kawabe Y; Eguchi K; The First Department of Internal Medicine, and the Department of; Hospital Pharmacy, Nagasaki University School of Medicine, Japan.; NF-kappaB is required for prevention of apoptosis. We examined the importance of human T-cell leukemia virus-I (HTLV-I) Tax protein to stimulate NF-kappaB nuclear translocation, thus preventing apoptosis. Jurkat cells and JPX-9 cells in which the inducible Tax expression plasmid vector was stably transfected were used
Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome.: Blood. 1999 Dec 1;94(11):3897-905. Unique Identifier : AIDSLINE MED/20042225; Coffey MJ; Phare SM; Cinti S; Peters-Golden M; Kazanjian PH; Divisions of Pulmonary and Critical Care Medicine and Infectious; Diseases, University of Michigan Medical Center, Ann Arbor, MI; 48109-0642, USA. coffeym@umich.edu; Leukotrienes (LT) are mediators derived from the 5-lipoxygenase (5-LO) pathway, which play a role in host defense, and are synthesized by both monocytes (peripheral blood monocyte [PBM]) and neutrophils (PMN). Because 5-LO metabolism is reduced in alveolar macrophages and PMN from acquired immunodeficiency syndrome (A
Zidovudine prophylaxis and perinatal HIV-1 transmission [letter]: Acta Paediatr. 1999 Nov;88(11):1298. Unique Identifier : AIDSLINE MED/20057397; Zuccotti GV; Ferraris G; Agostoni C; Rancilio L; Ravizza M; Bucceri AM; Riva E; Marini A
Salivary gland cancer in the United States.: Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1095-100. Unique Identifier : AIDSLINE MED/20078503; Sun EC; Curtis R; Melbye M; Goedert JJ; Division of Cancer Epidemiology and Genetics, National Cancer; Institute, NIH, Rockville, Maryland 20852, USA.; The risk of salivary gland cancer (SGC) is increased in atomic bomb survivors and after radiotherapy, but other risk factors are not well established. Some studies have suggested an association of SGC with breast cancer and with exposure to various viruses or UVB radiation. Corroborating evidence of these associations
Activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells.: Leuk Lymphoma. 1999 Dec;36(1-2):15-23. Unique Identifier : AIDSLINE MED/20078607; Tanaka Y; The First Department of Internal Medicine, University of; Occupational and Environmental Health, Japan, School of Medicine,; Kitakyushu. tanaka@med.uoeh-u.ac.jp; Adult T cell leukemia (ATL) is characterized by massive infiltration of circulating ATL cells into a variety of tissues, a finding often associated with poor prognosis. Leukocyte migration from circulation into tissue depends on integrin-mediated adhesion to endothelium and integrins are tightly regulated by several s
Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma.: Unique Identifier : AIDSLINE MED/20078612; Matsushita K; Matsumoto T; Ohtsubo H; Fujiwara H; Imamura N; Hidaka S; Kukita T; Tei C; Matsumoto M; Arima N; Acute leukemia and lymphoma varieties of adult T-cell leukemia/lymphoma (ATL) usually carry a poor prognosis. While etoposide is generally useful for treating ATL, especially as a daily oral maintenance regimen, etoposide has not proven effective in severe types of ATL efficient in some patients. Of 87 ATL patients wh
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1999 Nov 26;9(48):431-3. Unique Identifier : AIDSLINE MED/20060237
Monitoring the transmission of antiviral resistance in HIV in the United Kingdom.: Commun Dis Rep CDR Wkly. 1999 Dec 3;9(49):435, 438. Unique Identifier : AIDSLINE MED/20066345
Different models, different trees: the geographic origin of PTLV-I.: Mol Phylogenet Evol. 1999 Nov;13(2):336-47. Unique Identifier : AIDSLINE MED/20072933; Kelsey CR; Crandall KA; Voevodin AF; Department of Zoology, Brigham Young University, Provo, Utah; 84602-5255, USA.; Using nucleotide sequences from three genomic regions of the human and simian T-cell lymphotropic virus type I (HTLV-I/STLV-I)-consisting of 69 sequences from a 140-bp segment of the pol region, 98 sequences from a 503-bp segment of the LTR, and 154 sequences from a 386-bp segment of the env region-we tested two hypot
Clinical, immunohistochemical and phenotypic features of aggressive nodal cytotoxic lymphomas, including alpha/beta, gamma/delta T-cell and natural killer cell types.: Virchows Arch. 1999 Aug;435(2):92-100. Unique Identifier : AIDSLINE MED/20067413; Ohshima K; Suzumiya J; Sugihara M; Kanda M; Shimazaki K; Kawasaki C; Haraoka S; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; Cytotoxic cells include natural killer (NK) cells and cytotoxic alpha beta and gamma delta T lymphocytes (CTLs). These cells express cytotoxic molecules of T-cell restricted intracellular antigen (TIA-1), and activated cytotoxic molecules of perforin, granzyme B, and FasL. Recent studies suggest that most extranodal T
Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages.: Unique Identifier : AIDSLINE MED/99441284; Kang BY; Song YJ; Kim KM; Choe YK; Hwang SY; Kim TS; College of Pharmacy, Chonnam National University, Kwangju; 500-757, South Korea.; 1 Interleukin-12 (IL-12) plays a central role in the immune system by driving the immune response towards T helper 1 (Th1) type responses which are characterized by high IFN-gamma and low IL-4 production. In this study we investigated the effects of curcumin, a natural product of plants obtained from Curcuma longa (tu
CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers.: Immunity. 1999 Nov;11(5):579-90. Unique Identifier : AIDSLINE MED/20057140; Gandy KL; Domen J; Aguila H; Weissman IL; Department of Pathology and Developmental Biology, Stanford; University Medical Center, Stanford University, California 94305,; USA. gandy001@mc.duke.edu; Although purified hematopoietic stem cells (HSC) are sufficient to engraft irradiated allogeneic recipients, bone marrow (BM) contains other cells that facilitate engraftment. Here, several candidate facilitators were tested by cotransplantation with HSC. Both TCR+ and TCR- CD8alpha+ BM subpopulations have facilitativ
[Vacuolar myelopathy associated with AIDS: premortem diagnosis by MRI (letter)]: Rev Neurol. 1999 Sep 1-15;29(5):491-2. Unique Identifier : AIDSLINE MED/20051646; Cozar-Bartos M; Fernandez-Larraz L; Villarreal M; Villalon M; Villacampa V; Mazas L; Valero P
The International Prognostic Index can be used as a guide to treatment decisions regarding patients with human immunodeficiency virus-related systemic non-Hodgkin lymphoma.: Cancer. 1999 Dec 1;86(11):2391-7. Unique Identifier : AIDSLINE MED/20059595; Rossi G; Donisi A; Casari S; Re A; Cadeo G; Carosi G; Sezione Ematologia, Spedali Civili, Brescia, Italy.; BACKGROUND: The International Prognostic Index (IPI) effectively separates aggressive lymphomas into four groups with significantly different responses to therapy and survival. The authors have applied the IPI to evaluate a series of patients with human immunodeficiency virus (HIV) related lymphoma, a disease for whic
Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation.: Cancer Res. 1999 Dec 1;59(23):5887-91. Unique Identifier : AIDSLINE MED/20072245; Suganuma M; Kawabe T; Hori H; Funabiki T; Okamoto T; Department of Molecular Genetics, Nagoya City University School; of Medicine, Nagoya, Japan.; We devised two short peptides corresponding to amino acids 211-221 of human Cdc25C fused with a part of HIV1-TAT. These peptides inhibited hChk1 and Chk2/HuCds1 kinase activity in vitro and specifically abrogated the G2 checkpoint in vivo. These peptides sensitized p53-defective cancer cell lines to DNA-damaging agent
Retroviral DNA integration.: Microbiol Mol Biol Rev. 1999 Dec;63(4):836-43, table of contents. Unique Identifier : AIDSLINE MED/20054902; Hindmarsh P; Leis J; Department of Biochemistry, Case Western Reserve University; School of Medicine, Cleveland, Ohio 44106, USA.; DNA integration is a unique enzymatic process shared by all retroviruses and retrotransposons. During integration, double-stranded linear viral DNA is inserted into the host genome in a process catalyzed by the virus-encoded integrase (IN). The mechanism involves a series of nucleophilic attacks, the first of which re
Trends in world population: how will the millenium compare with the past?: Hum Reprod Update. 1999 Sep-Oct;5(5):500-5. Unique Identifier : AIDSLINE MED/20047612; Raleigh VS; National Institute of Epidemiology, University of Surrey,; Guildford, UK.; This paper reviews historical and projected trends in world population numbers, and the underlying determinants of those trends. Whereas the world s population has shown little change over most of its one million-year history, the past 200 years have witnessed dramatic changes in fertility, mortality and population gr
Prophylactic contraceptives for HIV/AIDS.: Hum Reprod Update. 1999 Sep-Oct;5(5):506-14. Unique Identifier : AIDSLINE MED/20047613; Uckun FM; D'Cruz OJ; Department of Virology, Hughes Institute, St Paul, Minnesota; 55113, USA. faith_uckun@mercury.ih.org; The current pandemic of sexually transmitted human immunodeficiency virus (HIV) infection--the causative agent of acquired immunodeficiency syndrome (AIDS), has created an urgent need for a new type of contraceptive: one that is both a spermicide and a microbicide. Because most women at risk for HIV infection are of r
The AIDS diagnosis--down but certainly not out [editorial]: Sex Transm Infect. 1999 Aug;75(4):213-4. Unique Identifier : AIDSLINE MED/20082165; Goldberg D; Evans B
Opportunistic infections in the era of HAART [editorial]: Sex Transm Infect. 1999 Aug;75(4):214-7. Unique Identifier : AIDSLINE MED/20082166; Matthews G; Pozniak AL
Immune reconstitution in HIV-1 infected subjects treated with potent antiretroviral therapy.: Sex Transm Infect. 1999 Aug;75(4):218-24. Unique Identifier : AIDSLINE MED/20082167; Kaufmann GR; Zaunders J; Cooper DA; Centre for Immunology, St Vincent's Hospital, Sydney, NSW,; Australia.; The introduction of potent antiretroviral drug regimens contributed to a decline in HIV-1 associated morbidity and mortality. Clinical observations of spontaneous remission of previously untreatable opportunistic infections in subjects on highly active antiretroviral therapy (HAART) reflect the substantial degree of i
Homosexual men's HIV related sexual risk behaviour in Scotland.: Sex Transm Infect. 1999 Aug;75(4):242-6. Unique Identifier : AIDSLINE MED/20082172; Hart GJ; Flowers P; Der GJ; Frankis JS; MRC Social and Public Health Sciences Unit, University of; Glasgow.; OBJECTIVE: To date, the epidemic of HIV infection in Scotland has been primarily associated with injecting drug use. However, the epidemiology of HIV in Scotland changed in the late 1980s, with homosexual men becoming the largest group at risk of HIV infection and AIDS. Our aim was to describe homosexual men s sexual
Survival and progression of HIV disease in women attending GUM/HIV clinics in Britain and Ireland. Study Group for the MRC Collaborative Study of HIV Infection in Women.: Sex Transm Infect. 1999 Aug;75(4):247-52. Unique Identifier : AIDSLINE MED/20082173; OBJECTIVES: To describe the pattern of clinical disease in women with HIV infection and to examine the effect of potential cofactors, including oral contraceptive use, alcohol and smoking, ethnic group, and route of HIV transmission, on progression to AIDS and death. DESIGN: Prospective observational cohort study. SET
Association of human papillomavirus with HIV and CD4 cell count in women with high or low numbers of sex partners.: Sex Transm Infect. 1999 Aug;75(4):253-7. Unique Identifier : AIDSLINE MED/20082174; Piper MA; Severin ST; Wiktor SZ; Unger ER; Ghys PD; Miller DL; Horowitz IR; Greenberg AE; Reeves WC; Vernon SD; National Cancer Institute, Rockville, MD, USA.; OBJECTIVE: To explore whether HIV serostatus (HIV-1, HIV-2, and dual (HIV-D) reactivity) and CD4 cell count affect human papillomavirus (HPV) in two groups of women from Cote d Ivoire . METHODS: We conducted a cross sectional study of two groups of women. One group had low numb
HIV and human papillomavirus as independent risk factors for cervical neoplasia in women with high or low numbers of sex partners.: Sex Transm Infect. 1999 Aug;75(4):258-60. Unique Identifier : AIDSLINE MED/20082175; Vernon SD; Unger ER; Piper MA; Severin ST; Wiktor SZ; Ghys PD; Miller DL; Horowitz IR; Greenberg AE; Reeves WC; Centers for Disease Control and Prevention, Department of Health; and Human Services, Atlanta, GA 30333, USA.; OBJECTIVE: To explore whether HIV types 1 and 2 and CD4 cell count affect cervical neoplasia independent of human papillomavirus (HPV) in women with high or low numbers of sexual partners residing in Abidjan, Cote d Ivoire . METHODS: The study population and methods are describ
Asymptomatic urethritis and detection of HIV-1 RNA in seminal plasma.: Sex Transm Infect. 1999 Aug;75(4):261-3. Unique Identifier : AIDSLINE MED/20082176; Winter AJ; Taylor S; Workman J; White D; Ross JD; Swan AV; Pillay D; Whittall Street Clinic, Birmingham.; OBJECTIVE: To define risk factors for detection of HIV-1 RNA in semen in men attending the two largest HIV clinics in the West Midlands. METHODS: 94 HIV-1 seropositive men at any stage of infection donated matched semen and blood samples. 36 subjects (38%) were on no antiretroviral treatment, 12 (13%) were on dual the
Cardiovascular autonomic neuropathy in HIV infected patients.: Sex Transm Infect. 1999 Aug;75(4):264-7. Unique Identifier : AIDSLINE MED/20082177; Rogstad KE; Shah R; Tesfaladet G; Abdullah M; Ahmed-Jushuf I; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield.; OBJECTIVE: To evaluate the presence and extent of autonomic dysfunction in HIV infected individuals of one ethnic group. DESIGN: Prospective, age-sex matched study. METHODS: 25 patients (seven asymptomatic (HIV), eight AIDS related complex (ARC), 10 AIDS) and 25 controls were recruited from patients and staff at the A
HIV protease inhibitors, the lipodystrophy syndrome and polycystic ovary syndrome--is there a link?: Sex Transm Infect. 1999 Aug;75(4):268-9. Unique Identifier : AIDSLINE MED/20082178; Wilson JD; Dunham RJ; Balen AH; Department of Genitourinary Medicine, General Infirmary at Leeds.
Seroprevalence of HIV, hepatitis B, and syphilis in an urban population and isolated villages in Gabon.: Sex Transm Infect. 1999 Aug;75(4):271. Unique Identifier : AIDSLINE MED/20082180; Bertherat E; Nabias R; Georges-Courbot MC; Renaut A; Centre International de Recherches Medicales de Franceville,; Gabon.
"Try this HIV test"--an evaluation of a mass media campaign targeting homosexual men [letter]: Sex Transm Infect. 1999 Aug;75(4):273. Unique Identifier : AIDSLINE MED/20082181; Sherr L; Nardone A; Leaity S; Wells H; Mercey D; Elford J
Prevalence of STDs and HIV infection among immigrant sex workers attending an STD centre in Bologna, Italy [letter]: Sex Transm Infect. 1999 Aug;75(4):273-4. Unique Identifier : AIDSLINE MED/20082182; D'Antuono A; Cocci C; Carla E; de Tommaso S
Cushing's syndrome and severe adrenal suppression in patients treated with ritonavir and inhaled nasal fluticasone [letter]: Sex Transm Infect. 1999 Aug;75(4):274. Unique Identifier : AIDSLINE MED/20082183; Chen F; Kearney T; Robinson S; Daley-Yates PT; Waldron S; Churchill DR
HIV associated eosinophilic folliculitis--differential diagnosis and management.: Sex Transm Infect. 1999 Oct;75(5):291-3. Unique Identifier : AIDSLINE MED/20083723; Simpson-Dent S; Fearfield LA; Staughton RC; Department of Dermatology, Chelsea and Westminster Hospital,; London.; Eosinophilic folliculitis (EF) is a chronic, intensely pruritic condition of unknown pathogenesis that causes marked morbidity in those HIV patients whom it affects. There is a wide differential diagnosis of itchy skin conditions in HIV which are amenable to different treatments. It is therefore essential to take a bi
Trends in undiagnosed HIV-1 infection among attenders at genitourinary medicine clinics, England, Wales, and Northern Ireland: 1990-6.: Sex Transm Infect. 1999 Oct;75(5):332-6. Unique Identifier : AIDSLINE MED/20083731; Simms I; Rogers P; Catchpole M; McGarrigle CA; Nicoll A; HIV and STD Division, Communicable Disease Surveillance Centre,; London.; OBJECTIVE: To describe trends in seroprevalence of undiagnosed HIV-1 infection among attenders at 15 genitourinary medicine clinics in England, Wales, and Northern Ireland between 1990 and 1996. METHOD: Prospective, cross sectional
Poor reduction of HIV-1 RNA titres in nucleoside reverse transcriptase inhibitor experienced patients treated with indinavir combination therapy.: Sex Transm Infect. 1999 Oct;75(5):337-9. Unique Identifier : AIDSLINE MED/20083732; Ball JK; Rowe T; Curran R; Irving WL; Beards GM; Sontag G; Youle M; Moyle G; Pillay D; Department of Clinical Laboratory Sciences, University of; Nottingham, Queen's Medical Centre.; OBJECTIVES: The long term effectiveness of combination therapy at reducing viral loads in seminal fluid and blood plasma obtained from HIV-1 infected men who had undergone previous antiretroviral therapy was assessed. METHODS: Samples of semen and blood were obtained f
Risky business: health and safety in the sex industry over a 9 year period.: Sex Transm Infect. 1999 Oct;75(5):340-3. Unique Identifier : AIDSLINE MED/20083733; Ward H; Day S; Weber J; Department of Epidemiology and Public Health, Imperial College; School of Medicine, St Mary's Hospital, London.; OBJECTIVES: To assess whether a previously established low sexually transmitted infection/HIV risk in prostitutes in London has been sustained, and to measure other occupational risks, including mortality. DESIGN: 9 year prospective study in west London. SUBJECTS: 402 prostitutes recruited from 1985 to 1991, 320 were
Is partner notification in the public interest?: Sex Transm Infect. 1999 Oct;75(5):354-7. Unique Identifier : AIDSLINE MED/20083738
Sexually transmitted infections and AIDS in the tropics [letter]: Sex Transm Infect. 1999 Oct;75(5):362-3. Unique Identifier : AIDSLINE MED/20083742; Ayra OP; Hart CA
National guideline for the management of molluscum contagiosum. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases).: Sex Transm Infect. 1999 Aug;75 Suppl 1:S80-1. Unique Identifier : AIDSLINE MED/20083765
National guideline for the management of adult victims of sexual assault. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases).: Sex Transm Infect. 1999 Aug;75 Suppl 1:S82-4. Unique Identifier : AIDSLINE MED/20083766
Quantitative determination of thalidomide in human serum with high-performance liquid chromatography using protein precipitation with trichloroacetic acid and ultraviolet detection.: J Chromatogr B Biomed Sci Appl. 1999 Nov 12;734(2):203-10. Unique Identifier : AIDSLINE MED/20061167; Torano JS; Verbon A; Guchelaar HJ; Department of Pharmacy, Academic Medical Center, University of; Amsterdam, The Netherlands.; A validated and precise reversed-phase high-performance liquid chromatographic method for the determination of thalidomide in serum, with phenacetin as an internal standard, is described. Protein precipitation, using trichloroacetic acid, was used for clean-up. The aliquot was chromatographed on a octadecyl column, us
Progressive multifocal leukoencephalopathy case report and review.: WMJ. 1999 Sep-Oct;98(5):50-1. Unique Identifier : AIDSLINE MED/20073283; Massa CS; Wagner DK; Medical College of Wisconsin, USA.
Interpreting DNA fingerprint clusters of Mycobacterium tuberculosis. European Concerted Action on Molecular Epidemiology and Control of Tuberculosis.: Int J Tuberc Lung Dis. 1999 Dec;3(12):1055-60. Unique Identifier : AIDSLINE MED/20066066; Glynn JR; Bauer J; de Boer AS; Borgdorff MW; Fine PE; Godfrey-Faussett P; Vynnycky E; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK. j.glynn@lshtm.ac.uk; Many studies of tuberculosis have defined clusters of patients on the basis of shared DNA fingerprint patterns of their Mycobacterium tuberculosis isolates. Clustering has been equated with recent transmission, and factors associated with clustering have been sought as a guide to population subgroups with high rates o
Who fails to complete tuberculosis treatment? Temporal trends and risk factors for treatment interruption in a community-based directly observed therapy programme in a rural district of South Africa.: Int J Tuberc Lung Dis. 1999 Dec;3(12):1081-7. Unique Identifier : AIDSLINE MED/20066070; Connolly C; Davies GR; Wilkinson D; Centre for Epidemiological Research in Southern Africa, South; African Medical Research Council.; SETTING: Hlabisa Tuberculosis Programme, Hlabisa, South Africa . OBJECTIVE: To determine trends in and risk factors for interruption of tuberculosis treatment. METHODS: Data were extracted from the control programme database starting in 1991. Temporal trends in treatment interrupti
Humoral immune responses to multiple antigens of Mycobacterium tuberculosis in tuberculosis patients co-infected with the human immunodeficiency virus.: Int J Tuberc Lung Dis. 1999 Dec;3(12):1127-31. Unique Identifier : AIDSLINE MED/20066077; Colangeli R; Antinori A; Cingolani A; Ortona L; Lyashchenko K; Fadda G; Gennaro ML; Public Health Research Institute, New York, New York 10016, USA.; A panel of ten protein antigens of Mycobacterium tuberculosis was used to evaluate serum antibody responses to tuberculosis in patients co-infected with the human immunodeficiency virus (HIV) and in HIV-infected control individuals without tuberculosis. Most (70%) of the tuberculosis patients had serum reactivity to a
AIDS and TB drug absorption [letter]: Int J Tuberc Lung Dis. 1999 Dec;3(12):1143-4. Unique Identifier : AIDSLINE MED/20066081; Peloquin CA; Berning SE; Huitt GA; Iseman MD
Childhood TB/HIV co-infection: correction, confusion and compliance [letter]: Int J Tuberc Lung Dis. 1999 Dec;3(12):1144. Unique Identifier : AIDSLINE MED/20066082; Graham SM; Harries AD
AIDS-related Kaposi's sarcoma: a phase II study of liposomal doxorubicin. The TLC D-99 Study Group.: Clin Cancer Res. 1999 Nov;5(11):3432-7. Unique Identifier : AIDSLINE MED/20055672; Cheung TW; Remick SC; Azarnia N; Proper JA; Barrueco JR; Dezube BJ; Division of Neoplastic Diseases and Infectious Diseases, Mount; Sinai School of Medicine, New York, New York 10029, USA.; TLC D-99 is a unique liposomal formulation of doxorubicin that consists of phosphatidyl choline/cholesterol. The objectives of the study were to evaluate safety and efficacy of two doses of TLC D-99 in the treatment of patients with AIDS-related Kaposi s Sarcoma (KS). Forty HIV-infected persons with biopsy-proven KS w
Recent advantages in cannabinoid research.: Forsch Komplementarmed. 1999 Oct;6 Suppl 3:16-20. Unique Identifier : AIDSLINE MED/20045173; Mechoulam R; Hebrew University, Medical Faculty, Jerusalem, Israel.; Mechou@yam-suff.cc.huji.ac.il; Although the active component of cannabis Delta9-THC was isolated by our group 35 years ago, until recently its mode of action remained obscure. In the last decade it was established that Delta9-THC acts through specific receptors - CB1 and CB2 - and mimics the physiological activity of endogenous cannabinoids of two
Unsafe injections in the developing world and transmission of bloodborne pathogens: a review.: Bull World Health Organ. 1999;77(10):789-800. Unique Identifier : AIDSLINE MED/20060611; Simonsen L; Kane A; Lloyd J; Zaffran M; Kane M; World Health Organization, Geneva, Switzerland.; Unsafe injections are suspected to occur routinely in developing countries. We carried out a literature review to quantify the prevalence of unsafe injections and to assess the disease burden of bloodborne infections attributable to this practice. Quantitative information on injection use and unsafe injections (define
Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates.: Bull World Health Organ. 1999;77(10):801-7. Unique Identifier : AIDSLINE MED/20060612; Kane A; Lloyd J; Zaffran M; Simonsen L; Kane M; Trinity College, Duke University, Durham, NC, USA.; Thousands of millions of injections are delivered every year in developing countries, many of them unsafe, and the transmission of certain bloodborne pathogens via this route is thought to be a major public health problem. In this article we report global and regional estimates of the number of hepatitis B virus (HBV)
The cost of unsafe injections.: Bull World Health Organ. 1999;77(10):808-11. Unique Identifier : AIDSLINE MED/20060613; Miller MA; Pisani E; Children's Vaccine Initiative, Geneva, Switzerland.; millermark@who.ch; Unsafe injection practices are associated with substantial morbidity and mortality, particularly from hepatitis B and C and human immunodeficiency virus (HIV) infections. These inadvertently transmitted bloodborne diseases become manifest some considerable time after infection and hence may not be appropriately accoun
Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue.: Clin Immunol. 1999 Dec;93(3):239-44. Unique Identifier : AIDSLINE MED/20071220; Schroeder JR; Saah AJ; Ambinder RF; Martinez-Maza O; Crabb Breen E; Variakojis D; Margolick JB; Jacobson LP; Rowe DT; Hoover DR; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland, USA.; The cytokine soluble CD23 (sCD23) acts as a B cell growth factor and is associated with Epstein-Barr virus (EBV) infection. To elucidate the role sCD23 might play in the pathogenesis of AIDS-related non-Hodgkin s lymphoma (AIDS NHL), 101 AIDS NHL patients from the Multicenter AIDS
Lymphocyte proliferation assays may underestimate antigen responsiveness in human immunodeficiency virus infection.: Clin Immunol. 1999 Dec;93(3):245-9. Unique Identifier : AIDSLINE MED/20071221; Patki AH; Purvis SF; Meyerson HJ; Lederman MM; Case Western Reserve University School of Medicine, Cleveland,; Ohio 44106, USA.; The objective of this study was to examine the relationships among lymphocyte proliferation, interferon-gamma (IFN-gamma) production, and apoptosis in peripheral blood mononuclear cells (PBMC) of HIV-1-infected patients and controls. PBMC were prepared from 19 HIV-1-infected patients and 16 healthy controls. Using tet
A human anti-HIV autoantibody enhances EBV transformation and HIV infection.: Clin Immunol. 1999 Dec;93(3):263-73. Unique Identifier : AIDSLINE GENBANK/AF175560; Cavacini LA; Wisnewski A; Peterson JE; Montefiori D; Emes C; Duval M; Kingsbury G; Wang A; Scadden D; Posner MR; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Boston, Massachusetts 02215, USA.; A highly specific, human IgG mAb, F223, which reacts with both HIV-1-infected cells and uninfected lymphoid cells, has been derived. F223 reacts with gp120 but fails to neutralize viral infection. The antibody does enhance HIV-1 infection in a complement-dependent manner. The autoantigen recognized by F223 is expresse
Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells.: Clin Immunol. 1999 Dec;93(3):294-301. Unique Identifier : AIDSLINE MED/20071227; Chang WK; Yang KD; Shaio MF; Graduate Institute of Medical Sciences, National Defense Medical; Center, Taipei, Taiwan, Republic of China.; Decreased glutamine concentrations are found in patients with catabolic stress and are related to susceptibility to infections. In this study, we evaluated the role of glutamine in Th1/Th2 cytokine responses. Peripheral blood mononuclear cells were stimulated with phytohemagglutinin (PHA), live attenuated bacillus Cal
Recurrent respiratory papillomatosis: altered CD8(+) T-cell subsets and T(H)1/T(H)2 cytokine imbalance.: Clin Immunol. 1999 Dec;93(3):302-11. Unique Identifier : AIDSLINE MED/20071228; Bonagura VR; Hatam L; DeVoti J; Zeng F; Steinberg BM; Department of Pediatrics, Schneider Children's Hospital, Long; Island Jewish Medical Center, 269-01 76th Avenue, New Hyde Park,; New York 11040, USA. bonagura@lij.edu; Human papillomaviruses (HPVs) cause benign papillomas and squamous cell carcinomas in the genital and respiratory tracts. Recurrent respiratory papillomas (RRP) generate a high level of morbidity and significant mortality because of their location, resistance to treatment, and relentless recurrence that can vary in fr
Cytomegalovirus pneumonitis as an initial presentation in an HIV-infected patient.: Conn Med. 1999 Oct;63(10):585-8. Unique Identifier : AIDSLINE MED/20045510; Zhao GG; Li JY; Atlas E; Cleary JP; Department of Medicine, Norwalk Hospital, Yale University School; of Medicine, USA.; Human immunodeficiency (HIV) infection often presents with an unusual symptom complex. Although cytomegalovirus ( CMV ) is a frequent opportunistic infection in the late stage of acquired immunodeficiency syndrome (AIDS), CMV p
Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees.: Drug Metab Dispos. 1999 Dec;27(12):1434-47. Unique Identifier : AIDSLINE MED/20040209; Riska PS; Joseph DP; Dinallo RM; Davidson WC; Keirns JJ; Hattox SE; Department of Drug Metabolism and Pharmacokinetics, Boehringer; Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut; 06877-0368, USA.; The study objectives were to characterize the metabolism of nevirapine (NVP) in mouse, rat, rabbit, dog, monkey, and chimpanzee after oral administration of carbon-14-labeled or unlabeled NVP. Liquid scintillation counting quantitated radioactivity an
Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.: Drug Metab Dispos. 1999 Dec;27(12):1488-95. Unique Identifier : AIDSLINE MED/20040215; Erickson DA; Mather G; Trager WF; Levy RH; Keirns JJ; Department of Drug Metabolism and Pharmacokinetics, Boehringer; Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877,; USA. derickso@rdg.boehringer-ingelheim.com; Nevirapine (NVP), a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is concomitantly administered to patients with a variety of medications. To assess the potential for its involvement in drug interactions, cytochrome P-450 (CYP) reaction phenotyping of NVP to its four oxidative metabolites, 2-, 3-, 8-, and 1
[AIDS is an immediate theme]: Dtsch Med Wochenschr. 1999 Nov 19;124(46):A16. Unique Identifier : AIDSLINE MED/20067350; Brockmeyer NH
HIV-1 tat transcriptional activity is regulated by acetylation.: EMBO J. 1999 Nov 1;18(21):6106-18. Unique Identifier : AIDSLINE MED/20012920; Kiernan RE; Vanhulle C; Schiltz L; Adam E; Xiao H; Maudoux F; Calomme C; Burny A; Nakatani Y; Jeang KT; Benkirane M; Van Lint C; Laboratoire de Virologie Moleculaire et Transfert de Gene,; Institut de Genetique Humaine, UPR1142 Montpellier, 34396,; France.; The human immunodeficiency virus (HIV) trans- activator protein, Tat, stimulates transcription from the viral long-terminal repeats (LTR) through an RNA hairpin element, trans-activation responsive region (TAR). We and others have shown that trans-activator protein (Tat)-associated histone acetyltransferases (TAHs), p
Hepatic steatosis: a frequent non-specific finding in HIV-infected children.: Eur J Pediatr. 1999 Dec;158(12):971-4. Unique Identifier : AIDSLINE MED/20059670; Albisetti M; Braegger CP; Stallmach T; Willi UV; Nadal D; University Children's Hospital of Zurich, Infectious Diseases; Unit, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.; Thirty HIV-infected children were cross-sectionally examined for morphologic hepatic abnormalities, using ultrasonography or histology. Abdominal ultrasonography was performed in 27 children. The liver structure was normal in four patients, one of whom had moderate symptoms of the HIV infection and three of them sever
Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo.: Eur J Immunol. 1999 Dec;29(12):3914-24. Unique Identifier : AIDSLINE MED/20070939; Rodriguez-Palmero M; Hara T; Thumbs A; Hunig T; Institute for Virology and Immunobiology, University of; Wurzburg, Wurzburg, Germany.; The relative contribution of T cell receptor-versus CD28-mediated signals in co-stimulation of resting CD4 T cells is thought to influence their functional differentiation towards T helper (Th) 1 versus Th2 subsets. We have used a conventional and a mitogenic CD28-specific monoclonal antibody to assess the effect of p
CD8(+) T cell cytolytic activity independent of mitogen-activated protein kinase / extracellular regulatory kinase signaling (MAP kinase / ERK).: Eur J Immunol. 1999 Dec;29(12):3971-7. Unique Identifier : AIDSLINE MED/20070946; Lilic M; Kulig K; Messaoudi I; Remus K; Jankovic M; Nikolic-Zugic J; Vukmanovic S; Michael Heidelberger Division of Immunology Department of; Pathology and Kaplan Comprehensive Cancer Center, NYU Medical; Center, New York, USA.; Cytotoxicity is a major effector function of CD8(+) T cells. Although mitogen-activated protein kinase (MAP kinase) / extracellular regulatory kinase (ERK) activity is indispensable for cytotoxic activity of most CD8(+) T cells a portion of CD8(+) T cells appears resistant to MEK inhibition as cytotoxicity of bulk cul
Memory phenotype CD8(+) T cells persist in livers of mice protected against malaria by immunization with attenuated Plasmodium berghei sporozoites.: Eur J Immunol. 1999 Dec;29(12):3978-86. Unique Identifier : AIDSLINE MED/20070947; Guebre-Xabier M; Schwenk R; Krzych U; Department of Immunology, Division of Communicable Diseases and; Immunology, Walter Reed Army Institute of Research, Washington,; USA.; Natural exposure to Plasmodium parasites induces short-lived protective immunity. In contrast, exposure to radiation-attenuated sporozoites (gamma spz) promotes long-lasting protection that is in part mediated by CD8(+) T cells that target exoerythrocytic stage antigens. The mechanisms underlying the maintenance of lo
Presentation of epstein-barr virus latency antigens to CD8(+), interferon-gamma-secreting, T lymphocytes.: Eur J Immunol. 1999 Dec;29(12):3995-4001. Unique Identifier : AIDSLINE MED/20070949; Subklewe M; Chahroudi A; Bickham K; Larsson M; Kurilla MG; Bhardwaj N; Steinman RM; Laboratory of Cellular Physiology and Immunology Rockefeller; University, New York, NY 10021-6399, USA.; subklem@rockvax.rockefeller.edu; Epstein-Barr virus (EBV) infects more than 95 % of the human population and causes an asymptomatic life-long infection in the majority of EBV carriers. Cell-mediated immunity provides resistance to EBV, as demonstrated by the occurrence of EBV-induced post-transplant lymphoproliferative disease in immunosuppressed pat
Enrichment and detection of live antigen-specific CD4(+) and CD8(+) T cells based on cytokine secretion.: Eur J Immunol. 1999 Dec;29(12):4053-9. Unique Identifier : AIDSLINE MED/20070956; Brosterhus H; Brings S; Leyendeckers H; Manz RA; Miltenyi S; Radbruch A; Assenmacher M; Schmitz J; Miltenyi Biotec GmbH Bergisch Gladbach, Germany.; Following appropriate antigen-specific stimulation, CD4(+) and CD8(+) T lymphocytes rapidly express cytokines. Based on this stimulation-induced cytokine secretion and using cell surface affinity matrix technology we have developed a new method that permits specific, rapid and efficient detection, isolation and charac
The interplay between the duration of TCR and cytokine signaling determines T cell polarization.: Eur J Immunol. 1999 Dec;29(12):4092-101. Unique Identifier : AIDSLINE MED/20070960; Iezzi G; Scotet E; Scheidegger D; Lanzavecchia A; Basel Institute for Immunology, Basel, Switzerland. lezzi@bii.ch; Development of Th1 and Th2 effector lymphocytes is driven primarily by IL-12 or IL-4, but is also influenced by the strength of antigenic stimulation. However, the mechanism by which TCR signaling contributes to T cell polarization remains elusive. We show that in the presence of IL-12 a short TCR stimulation can lead
Effects of the human CD38 glycoprotein on the early stages of the HIV-1 replication cycle.: FASEB J. 1999 Dec;13(15):2265-76. Unique Identifier : AIDSLINE MED/20062719; Savarino A; Bottarel F; Calosso L; Feito MJ; Bensi T; Bragardo M; Rojo JM; Pugliese A; Abbate I; Capobianchi MR; Dianzani F; Malavasi F; Dianzani U; Department of Medical and Surgical Sciences, University of Turin,; Italy.; CD38 displays lateral association with the HIV-1 receptor CD4. This association is potentiated by the HIV-1 envelope glycoprotein gp120. The aim of this work was to evaluate the CD38 role in T cell susceptibility to HIV-1 infection. Using laboratory X4 HIV-1 strains and X4 and X4/R5 primary isolates, we found that CD3
Synthesis of IFN-gamma by CD8(+) T cells is preserved in HIV-infected women with HPV-related cervical squamous intraepithelial lesions.: Gynecol Oncol. 1999 Dec;75(3):379-86. Unique Identifier : AIDSLINE MED/20069528; Lee BN; Follen M; Tortolero-Luna G; Eriksen N; Helfgott A; Hammill H; Shearer WT; Reuben JM; Division of Pathology and Laboratory Medicine, The University of; Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.; OBJECTIVE: The aim of this study was to investigate whether coinfection with HIV affects the synthesis of Th1 and Th2 cytokines by peripheral blood T cells of women infected with human papillomavirus (HPV). METHODS: Cervical swabs and peripheral blood were obtained from women referred for colposcopy. HPV DNA by Digene
Human papillomavirus testing in primary screening for cervical cancer of human immunodeficiency virus-infected women, 1990-1998.: Gynecol Oncol. 1999 Dec;75(3):427-31. Unique Identifier : AIDSLINE MED/20069536; Petry KU; Bohmer G; Iftner T; Flemming P; Stoll M; Schmidt RE; Department of Gynecological Oncology, Medizinische Hochschule; Hannover, Podbielskistrasse 380, Hannover, 30659, Germany.; OBJECTIVE: Women infected with the human immunodeficiency virus (HIV) have an increased risk of cervical neoplasia while the value of cytologic screening is limited due to a high prevalence of inflammatory disease. The study was conducted to determine whether testing for human papillomavirus (HPV) DNA could improve pr
Absence of the deltaccr5 mutation in indigenous populations of the Brazilian Amazon.: Hum Genet. 1999 Nov;105(5):442-3. Unique Identifier : AIDSLINE MED/20065869; Leboute AP; de Carvalho MW; Simoes AL; Departamento de Genetica, Faculdade de Medicina de Ribeirao; Preto, Universidade de Sao Paulo, Brasil.; Carriers of the deltaccr5 allele, which contains a deletion of 32 bases in relation to the normal allele of the beta-chemokine receptor gene (CCR5), have increased resistance to HIV-1 infection. The higher frequency of this mutation in Europeans than in Blacks and Asians, has generated interest in determining its dist
SH2D1A mutation analysis for diagnosis of XLP in typical and atypical patients.: Hum Genet. 1999 Nov;105(5):501-5. Unique Identifier : AIDSLINE MED/20065878; Yin L; Ferrand V; Lavoue MF; Hayoz D; Philippe N; Souillet G; Seri M; Giacchino R; Castagnola E; Hodgson S; Sylla BS; Romeo G; International Agency for Research on Cancer, Lyon, France.; X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency to Epstein-Barr virus (EBV). The gene responsible for XLP has recently been identified as the four-exon SH2D1A gene encoding a 128-amino-acid protein that contains an SH2-domain. Functional studies indicate the SH2D1A protein acts as a reg
Low dose of orally administered antigen down-regulates the T helper type 2-response in a murine model of dust mite hypersensitivity.: Immunology. 1999 Nov;98(3):338-44. Unique Identifier : AIDSLINE MED/20051313; Sato MN; Carvalho AF; Silva AO; MacIel M Jr; Fusaro AE; Duarte AJ; Laboratorio de Alergia e Imunologia Clinica e Experimental-LIM; 56, Faculdade de Medicina da Universidade de Sao Paulo, Sao; Paulo, Brazil.; One of the main goals of immunotherapy of allergic diseases is the down-regulation of the type I hypersensitivity reaction. We investigated in this study the effect of oral administration of varying doses (0.25, 1.0, 4.0 and 10 mg) of dust mite extract (Dermatophagoides pteronyssinus, Dp) in sensitized A/Sn mice. A ma
Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool.: Immunology. 1999 Nov;98(3):400-5. Unique Identifier : AIDSLINE MED/20051322; Webb LM; Foxwell BM; Feldmann M; Kennedy Institute of Rheumatology, Hammersmith, London, UK.; The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova
L-selectin expression on thymic emigrants defines two distinct tissue-migration pathways.: Immunology. 1999 Nov;98(3):422-6. Unique Identifier : AIDSLINE MED/20051325; Holder JE; Kimpton WG; Washington EA; Cahill RN; Laboratory for Foetal and Neonatal Immunology, The University of; Melborne, Parkville, Victoria, Australia.; We have studied the appearance and phenotype of recent thymic emigrants in blood, spleen and lymph nodes (LN) of neonatal lambs. Using in situ labelling of thymocytes with fluoroscein isothiocyanate (FITC), we examined the expression of the LN homing receptor L-selectin on alphabeta and gammadelta subsets of recent th
Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type-1.: Immunology. 1999 Nov;98(3):436-42. Unique Identifier : AIDSLINE MED/20051327; Ihata A; Watabe S; Sasaki S; Shirai A; Fukushima J; Hamajima K; Inoue J; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.; CD40 ligand is a costimulatory molecule which acts a potent immunomodulator. We found the mice inoculated with human CD40 ligand expression plasmid (pMEhCD40L) combined with human immunodeficiency virus type-1 (HIV-1) DNA vaccine exhibited both humoral and cellular antigen-specific immunological enhancement. The expre
Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28- CD8+ T-cell population.: Immunology. 1999 Nov;98(3):443-9. Unique Identifier : AIDSLINE MED/20051328; Weekes MP; Wills MR; Mynard K; Hicks R; Sissons JG; Carmichael AJ; Department of Medicine, University of Cambridge Clinical School,; UK.; The proportion of human peripheral blood CD8+ T cells that are CD57+ CD28- is low at birth but increases with age and in individuals infected with human cytomegalovirus (HCMV) or human immunodeficiency virus (HIV). These CD57+ CD28- CD8+ T cells contain large oligoclonal T-cell exp
Houdini's box: towards an understanding of AIDS virus escape from the cytotoxic T-lymphocyte response.: Immunogenetics. 1999 Nov;50(3-4):237-41. Unique Identifier : AIDSLINE MED/20069582; O'Connor DH; Watkins DI; Wisconsin Regional Primate Research Center, University of; Wisconsin, 1220 Capitol Court, Madison, WI 53715-1299, USA.
Cancer incidence in the African population of Harare, Zimbabwe: second results from the cancer registry 1993-1995.: Int J Cancer. 2000 Jan 1;85(1):54-9. Unique Identifier : AIDSLINE MED/20054376; Chokunonga E; Levy LM; Bassett MT; Mauchaza BG; Thomas DB; Parkin DM; Zimbabwe Cancer Registry, Parirenyatwa Hospital, Harare,; Zimbabwe. cancer_registry@healthnet.zw; The data of the population-based cancer registry in Harare, Zimbabwe , for 1993-1995 are presented and compared with those from 1990-1992. The most significant change in rates is the striking increase in the incidence of Kaposi s sarcoma (KS) in both men and women, compatible with
105Ad7 cancer vaccine stimulates anti-tumour helper and cytotoxic T-cell responses in colorectal cancer patients but repeated immunisations are required to maintain these responses.: Int J Cancer. 2000 Jan 1;85(1):87-92. Unique Identifier : AIDSLINE MED/20054382; Durrant LG; Buckley DJ; Robins RA; Spendlove I; CRC Department of Clinical Oncology, University of Nottingham,; Nottingham, UK. lindy.durrant@nott.ac.uk; 105AD7 is a human anti-idiotypic antibody that recognises the binding site of the anti-tumour antibody 791T/36 and can thereby mimic the CD55 antigen. The molecular basis of 105AD7 mimicry has been identified with 3 CDR regions of 105AD7 showing similarity to 3 regions of CD55. These regions have been analysed for pot
The infectious complications of anabolic-androgenic steroid injection.: Int J Sports Med. 1999 Nov;20(8):563-6. Unique Identifier : AIDSLINE MED/20072239; Rich JD; Dickinson BP; Feller A; Pugatch D; Mylonakis E; The Miriam Hospital and Brown University, Providence, Rhode; Island 02906, USA. Josiah_Rich@brown.edu; One million individuals in the United States alone are estimated to be current or past users of anabolic-androgenic steroids. In the United States fifty-percent of anabolic-androgenic steroid users administer their compounds intramuscularly, and twenty-five percent of adolescent anabol
Pathogenicity of selected Toxoplasma gondii isolates in young pigs.: Int J Parasitol. 1999 Aug;29(8):1307-19. Unique Identifier : AIDSLINE MED/20041999; Jungersen G; Jensen L; Riber U; Heegaard PM; Petersen E; Poulsen JS; Bille-Hansen V; Lind P; Danish Veterinary Laboratory, Copenhagen, Denmark. gju@svs.dk; The pathogenicity in 7-week-old pigs to five different Toxoplasma gondii strains of various host species origin was compared after i.v. inoculation of 10(4) tachyzoites. Additionally, one group of pigs was inoculated i.v. with 10(6) tachyzoites of the reference strain, SSI 119. In response to the infection a significa
Reporting delay in the AIDS Surveillance System of the Eastern Health Board [letter]: Ir Med J. 1999 Sep-Oct;92(6):405. Unique Identifier : AIDSLINE MED/20066370; O'Sullivan P; Barry J
Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase.: J Biol Chem. 1999 Nov 12;274(46):32924-30. Unique Identifier : AIDSLINE MED/20020266; Lewis DA; Bebenek K; Beard WA; Wilson SH; Kunkel TA; Laboratory of Structural Biology, NIEHS, National Institutes of; Health, Research Triangle Park, North Carolina 27709, USA.; Arginine 72 in human immunodeficiency virus type 1 reverse transcriptase (RT), a highly conserved residue among retroviral polymerases and telomerases, forms part of the binding pocket for the nascent base pair. We show here that replacement of Arg(72) by alanine strongly alters fidelity in a highly unusual manner. R7
Glucocorticoid can reduce the transcriptional activation of HIV-1 promoter through the reduction of active NF-kappaB.: J Cell Biochem. 1999;76(1):13-9. Unique Identifier : AIDSLINE MED/20047930; Kurata Si; Yamamoto N; Department of Biochemical Genetics, Medical Research Institute,; Tokyo Medical and Dental University, Yushima, Tokyo 113, Japan.; It is well documented that glucocorticoid (GC) can induce the transcription of the IkappaBalpha gene in several cell lines. GC treatment then increases IkappaBalpha protein levels and markedly reduces the amount of active NF-kappaB. NF-kappaB is a strong activator of HIV-1 promoter, but the mechanism by which GC influ
HIV-1 gp120 envelope protein modulates proliferation of human glomerular epithelial cells.: J Cell Biochem. 1999;76(1):61-70. Unique Identifier : AIDSLINE MED/20047935; Singhal PC; Reddy K; Franki N; Ding G; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York 11040, USA.; Glomerular epithelial cells (GEC) have been demonstrated to undergo morphological alterations in human immunodeficiency virus (HIV)-associated focal glomerulosclerosis. In the present study, we evaluated the effect of HIV-1 gp120 envelope protein on the growth of cultured human (H) GEC. gp120 protein enhanced (P
Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect [see comments]: Unique Identifier : AIDSLINE MED/20056165; Wang G; Slepushkin V; Zabner J; Keshavjee S; Johnston JC; Sauter SL; Jolly DJ; Dubensky TW Jr; Davidson BL; McCray PB Jr; Several problems limit the application of gene transfer to correct the cystic fibrosis (CF) Cl(-) transport defect in airway epithelia. These include inefficient transduction with vectors applied to the apical surface, a low rate of division by airway epithelial cells, failure of transgene expression to persist, and i
Bad for cats, good for humans? Modified feline immunodeficiency virus for gene therapy [comment]: J Clin Invest. 1999 Dec;104(11):1491-3. Unique Identifier : AIDSLINE MED/20056147; Crystal RG
Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis.: J Clin Invest. 1999 Dec;104(11):1549-57. Unique Identifier : AIDSLINE MED/20056155; Topham PS; Csizmadia V; Soler D; Hines D; Gerard CJ; Salant DJ; Hancock WW; LeukoSite Inc., Cambridge, Massachusetts 02142, USA.; During the development of nephrotoxic nephritis (NTN) in the mouse, we find that a variety of chemokines and chemokine receptors are induced: CCR1 (RANTES, MIP-1alpha), CCR2 (MCP-1), CCR5 (RANTES, MIP-1alpha, MIP-1beta), CXCR2 (MIP-2), and CXCR3 (IP-10). Their timing of expression indicated that CXCR2 and CCR1 are pro
Disclosure of HIV seropositivity.: J Clin Psychol. 1999 Sep;55(9):1041-9. Unique Identifier : AIDSLINE MED/20041738; Levy A; Laska F; Abelhauser A; Delfraissy JF; Goujard C; Boue F; Dormont J; University of Paris XI, Hopital Antoine Beclere, Clamart,; France.; Deciding whether or not to disclose one s HIV-positive status to another person is an important decision: the way each person experiences and copes with the illness is reflected in this choice. We conducted a study of 174 patients (29.3% of women) to examine how the decision to disclose or conceal was made, as well as
Dermatofibroma parasitized by Leishmania in HIV infection: a new morphologic expression of dermal Kala Azar in an immunodepressed patient.: J Cutan Pathol. 1999 Nov;26(10):516-9. Unique Identifier : AIDSLINE MED/20066926; Castellano VM; Rodriguez-Peralto JL; Alonso S; Gomez-De la Fuente E; Ibarrola C; Department of Pathology, Doce de Octubre University Hospital,; Universidad Complutense, Madrid, Spain.; Visceral leishmaniasis is a protozoan infection that may complicate the course of patients with human immunodeficiency virus (HIV). Dermatofibroma is a cutaneous fibrohistiocytic lesion considered neoplastic by some authors and inflammatory by others. Eruptive dermatofibromas have been described in patients with HIV i
Infection with parapoxvirus induces CD30-positive cutaneous infiltrates in humans.: J Cutan Pathol. 1999 Nov;26(10):520-2. Unique Identifier : AIDSLINE MED/20066927; Rose C; Starostik P; Brocker EB; Department of Dermatology, University of Wurzburg, Germany.; Expression of CD30 is a distinct feature of B- or T-cell activation, found in Hodgkin s disease, large cell anaplastic lymphoma, lymphomatoid papulosis, as well as in certain viral infections such as human T-lymphotropic virus type I, HIV, hepatitis B and C virus, and Epstein-Barr virus. Here, we report highly prolife
Effectiveness of a video-based motivational skills-building HIV risk-reduction intervention for inner-city African American men.: J Consult Clin Psychol. 1999 Dec;67(6):959-66. Unique Identifier : AIDSLINE MED/20064314; Kalichman SC; Cherry C; Browne-Sperling F; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53226, USA. sethk@mcw.edu; Interventions to reduce HIV risk behavior have shown promise but have demonstrated inconsistent effects with heterosexual men. This article reports a cognitive-behavioral HIV risk reduction intervention designed for heterosexually active African American men. Men (N = 117) recruited from a public clinic were randomly
Oral infections and other manifestations of HIV disease.: Infect Dis Clin North Am. 1999 Dec;13(4):879-900. Unique Identifier : AIDSLINE MED/20046076; Patton LL; van der Horst C; Department of Dental Ecology, School of Dentistry, University of; North Carolina, Chapel Hill, USA. Lauren_Patton@Dentistry.unc.edu; Oral lesions are important in the clinical spectrum of HIV/AIDS, arousing suspicion of acute seroconversion illness (aphthous ulceration and candidiasis), suggesting HIV infection in the undiagnosed individual (candidiasis, hairy leukoplakia, Kaposi s sarcoma, necrotizing ulcerative gingivitis), indicating clinical di
Th1 and Th2 deviation of myelin-autoreactive T cells by altered peptide ligands is associated with reciprocal regulation of Lck, Fyn, and ZAP-70.: J Immunol. 1999 Dec 15;163(12):6393-402. Unique Identifier : AIDSLINE MED/20054519; Singh RA; Zang YC; Shrivastava A; Hong J; Wang GT; Li S; Tejada-Simon MV; Kozovska M; Rivera VM; Zhang JZ; Multiple Sclerosis Research Laboratory, Department of Neurology,; Baylor College of Medicine, Houston, TX 77030, USA.; Th0 clones recognizing an immunodominant peptide of myelin basic protein (residues 83-99) were derived from patients with multiple sclerosis. We demonstrate that analogue peptides with alanine substitution at Val86 and His88 had a unique partial agonistic property in inducing Th0 -->Th1 and Th0 -->Th2 deviation of the
Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling.: J Immunol. 1999 Dec 15;163(12):6448-54. Unique Identifier : AIDSLINE MED/20054525; Brewer JM; Conacher M; Hunter CA; Mohrs M; Brombacher F; Alexander J; Department of Immunology, University of Glasgow, Western; Infirmary, Scotland, United Kingdom. j.m.brewer@clinmed.gla.ac.uk; Previous studies demonstrate that aluminium hydroxide adjuvant (alum) produces increased Th1 responses in IL-4-deficient mice compared with wild-type animals, although the continued production of IL-5 by spleen cells from these mice also indicates that Th2 responses are induced. In the present study, we demonstrate th
Stat6-dependent and -independent pathways for IL-4 production.: J Immunol. 1999 Dec 15;163(12):6536-40. Unique Identifier : AIDSLINE MED/20054536; Kaplan MH; Wurster AL; Smiley ST; Grusby MJ; Department of Microbiology and Immunology, Walther Oncology; Center, Indiana University School of Medicine, Indianapolis; 46202, USA.; Stat6 has been shown to have a crucial role in the IL-4-dependent differentiation of Th2 cells. In this report, we explore whether in vitro Th2 differentiation driven by altered costimulatory signals or Ag dose is Stat6 dependent. We find that blocking B7-1 signaling in vitro promotes the differentiation of IL-4-secre
Ability of a nondepleting anti-CD4 antibody to inhibit Th2 responses and allergic lung inflammation is independent of coreceptor function.: J Immunol. 1999 Dec 15;163(12):6557-66. Unique Identifier : AIDSLINE MED/20054539; Li L; Crowley M; Nguyen A; Lo D; Department of Immunology IMM-25, The Scripps Research Institute,; La Jolla, CA 92037, USA.; Nondepleting anti-CD4 Abs have been used in vivo to induce Ag-specific immunological tolerance in Th1 responses, including tissue allograft rejection and autoimmune diabetes. To examine whether this Ab (YTS177.9) acts by provoking a Th2 shift, we tested the effect in a mouse model of allergic lung inflammation. Intere
Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling.: J Immunol. 1999 Dec 15;163(12):6567-74. Unique Identifier : AIDSLINE MED/20054540; Coon ME; Diegel M; Leshinsky N; Klaus SJ; Immunology Program, Cell Therapeutics, Inc., Seattle, WA 98119,; USA.; We have previously shown that lisofylline (LSF) inhibits murine Th1-mediated disease in vivo by blocking IL-12-induced differentiation of Th1 cells. The cellular and molecular mechanisms underlying this inhibition were further explored by testing LSF in several IL-12-responsive model systems in vitro. IL-12-dependent
Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens.: J Immunol. 1999 Dec 15;163(12):6702-11. Unique Identifier : AIDSLINE MED/20054557; Hayashi N; Matsui K; Tsutsui H; Osada Y; Mohamed RT; Nakano H; Kashiwamura S; Hyodo Y; Takeda K; Akira S; Hada T; Higashino K; Kojima S; Nakanishi K; Third Department of Internal Medicine, Hyogo College of Medicine,; Nishinomiya, Japan.; Infection with Schistosoma mansoni, a portal vein-residing helminth, is well known to generate life cycle-dependent, systemic immune responses in the host, type 1 deviation during the prepatent period, and type 2 polarization after oviposition. Here we investigated local immunological changes in the liver after infect
Induction of Th2 responses and IgE is largely due to carbohydrates functioning as adjuvants on Schistosoma mansoni egg antigens.: J Immunol. 1999 Dec 15;163(12):6712-7. Unique Identifier : AIDSLINE MED/20054558; Okano M; Satoskar AR; Nishizaki K; Abe M; Harn DA Jr; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, MA 02115, USA.; Infection with the helminth parasite Schistosoma mansoni induces a pronounced Th2-type response that is associated with significant IgE production. To better understand how the parasite drives these responses, we investigated the relative roles of proteins and carbohydrates in driving Th2-type and/or IgE responses usi
Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation.: J Immunol. 1999 Dec 15;163(12):6725-31. Unique Identifier : AIDSLINE MED/20054560; Beissert S; Bluestone JA; Mindt I; Voskort M; Metze D; Mehling A; Luger TA; Schwarz T; Grabbe S; Ludwig-Boltzmann Institute for Cell Biology and Immunobiology of; the Skin, Department of Dermatology, University of Munster,; Germany. beisser@uni-muenster.de; Immunosuppression by UV light contributes significantly to the induction of skin cancer by suppressing the cell-mediated immune responses which control the development of carcinogenesis. The B7/CD28-CTLA-4 signaling pathway provides costimulatory signals essential for Ag-specific T cell activation. To investigate the
The adjacent flanking region plays a critical role in facilitating the presentation of the Listeria monocytogenes product lemA to H2 M3wt-restricted, peptide-specific murine CD8 cells.: J Immunol. 1999 Dec 15;163(12):6741-7. Unique Identifier : AIDSLINE MED/20054562; Kurlander RJ; Chao E; Fields J; Nataraj C; Clinical Pathology Department, Clinical Center, National; Institutes of Health, Bethesda, MD 20892, USA. rkurlander@nih.gov; Mice infected with Listeria monocytogenes (LM) generate CD8 effectors specific for f-MIGWII, the amino terminus of the bacterial product lemA presented by the class Ib MHC molecule H2 M3wt. lemA has several distinctive properties: 1) it is readily presented as an exogenous Ag in the absence of bacterial infection; 2)
A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms.: J Immunol. 1999 Dec 15;163(12):6756-61. Unique Identifier : AIDSLINE MED/20054564; Aberle JH; Aberle SW; Allison SL; Stiasny K; Ecker M; Mandl CW; Berger R; Heinz FX; Institute of Virology, University of Vienna, Austria.; We have conducted a DNA immunization study to evaluate how the immune response is influenced by the physical structure and secretion of the expressed Ag. For this purpose, we used a series of plasmid constructs encoding different forms of the envelope glycoprotein E of the flavivirus tick-borne encephalitis virus. The
In vivo administration of recombinant IL-2 to individuals infected by HIV down-modulates the binding and expression of the transcription factors ying-yang-1 and leader binding protein-1/late simian virus 40 factor.: J Immunol. 1999 Dec 15;163(12):6892-7. Unique Identifier : AIDSLINE MED/20054581; Bovolenta C; Camorali L; Lorini AL; Vallanti G; Ghezzi S; Tambussi G; Lazzarin A; Poli G; AIDS Immunophatogenesis Unit, DIBIT, Centro San Luigi, San; Raffaele Scientific Institute, Milan, Italy.; bovolenta.chiara@hsr.it; Leader binding protein-1 (LBP-1)/late SV40 factor (LSF) and ying yang-1 (YY1) transcription factors are involved in the regulation of HIV expression. In particular, YY1 and LBP-1 have been shown to cooperate in repressing HIV-1-long terminal repeat reporter gene expression by in vitro cotransfection experiments. Howev
Visceral leishmaniasis in clinical practice.: J Infect. 1999 Sep;39(2):112-6. Unique Identifier : AIDSLINE MED/20075618; Davidson RN; Department of Infectious Diseases and Tropical Medicine, Lister; Unit, Northwick Park Hospital, Harrow, Middlesex, UK.
HIV trends in African blood donors.: J Infect. 1999 Sep;39(2):122-8. Unique Identifier : AIDSLINE MED/20075620; Bouckenooghe A; Shandera W; Department of Medicine, Baylor College of Medicine, Houston, TX; 77030, USA.; OBJECTIVES: To assess trends over the last 12 years in HIV-1/HIV-2 seroprevalence among blood donors in African nations and to correlate trends with national AIDS policies, with the purpose of preventing future cases. METHODS: Using collated data of African seroepidemiologic studies published by the U.S. Bureau of the
Stavudine, lamivudine and indinavir in drug abusing and non-drug abusing HIV-infected patients: adherence, side effects and efficacy.: J Infect. 1999 Sep;39(2):141-5. Unique Identifier : AIDSLINE MED/20075623; Roca B; Gomez CJ; Arnedo A; Division of Infectious Diseases, Hospital General, Castellon,; Spain.; OBJECTIVES: To compare adherence and clinical outcome with highly active antiretroviral therapy (HAART) in intravenous drug users (IDUs) and subjects with other HIV risk behaviours (non-IDUs). METHODS: A total of 133 non-naive HIV-infected patients, 95 (71%) IDUs and 38 (29%) non-IDUs received triple drug therapy with
Flavobacterium spp. organisms as opportunistic bacterial pathogens during advanced HIV disease.: Unique Identifier : AIDSLINE MED/20075624; Manfredi R; Nanetti A; Ferri M; Mastroianni A; Coronado OV; Chiodo F; Department of Clinical and Experimental Medicine, University of; OBJECTIVE: To assess the role of Flavobacterium spp. infection in patients with HIV disease. METHODS: Clinical charts of 2412 consecutive HIV-infected patients hospitalized in a 8-year period were retrospectively reviewed, to identify all cases of Flavobacterium spp. infections, and to evaluate their occurrence and ou
Localized oral Fusarium infection in an AIDS patient with malignant lymphoma.: J Infect. 1999 Sep;39(2):153-4. Unique Identifier : AIDSLINE MED/20075625; Paugam A; Baixench MT; Frank N; Bossi P; de Pinieux G; Tourte-Schaefer C; Dupouy-Camet J; Parasitology-Mycology, Dermatology and Anatomopathology Unit,; Hopital Cochin, Paris, France.; We report here a case of localized oral Fusarium infection in an AIDS patient who developed an ulceration in the soft palate. Fusarium solani was identified by histopathology and culture. We believe this to be the second reported case of oral Fusarium infection in a patient with haematological malignancy and the first
Prevalence of undiagnosed hepatitis B and C, HIV and HTLV infections in hospital in-patients [letter]: J Infect. 1999 Sep;39(2):165-7. Unique Identifier : AIDSLINE MED/20075631; Regan FA; Hewitt P; Barbara JA; Contreras M
Quantitative structure-activity relationships and comparative molecular field analysis of TIBO derivatised HIV-1 reverse transcriptase inhibitors.: J Comput Aided Mol Des. 1999 Nov;13(6):563-77. Unique Identifier : AIDSLINE MED/20051604; Hannongbua S; Pungpo P; Limtrakul J; Wolschann P; Department of Chemistry, Faculty of Science, Kasetsart; University, Bangkok, Thailand. fscisph@ku.ac.th; Quantitative structure-activity relationships (QSAR) and Comparative Molecular Field Analysis (CoMFA) have been applied in order to explain the structural requirements of HIV-1 reverse transcriptase (HIV-1 RT) inhibitory activity of TIBO derivatives on the MT-4 cells. The best QSAR model is satisfactory in both statis
Increased incidence of Hodgkin's disease after allogeneic bone marrow transplantation.: J Clin Oncol. 1999 Oct;17(10):3122-7. Unique Identifier : AIDSLINE MED/99438178; Rowlings PA; Curtis RE; Passweg JR; Deeg HJ; Socie G; Travis LB; Kingma DW; Jaffe ES; Sobocinski KA; Horowitz MM; International Bone Marrow Transplant Registry, Medical College of; Wisconsin, Milwaukee, WI, USA.; PURPOSE: Immune dysregulation associated with allogeneic bone marrow transplantation (BMT) is linked to an increased risk of posttransplant lymphoproliferative disorders (PTLD); however, reports of Hodgkin s disease (HD) after transplantation are rare. PATIENTS AND METHODS: We evaluated the risk of HD among 18,531 per
Glioblastoma multiforme in a case of acquired immunodeficiency syndrome: investigation a possible oncogenic influence of human immunodeficiency virus on glial cells. Case report and review of the literature.: J Neurosurg. 2000 Jan;92(1):161-4. Unique Identifier : AIDSLINE MED/20081842; Vannemreddy PS; Fowler M; Polin RS; Todd JR; Nanda A; Department of Neurosurgery, Louisiana State University Medical; Center-Shreveport, 71130-3932, USA.; Malignant glioma is the most common primary brain neoplasm, but generally it is not included in the differential diagnosis of enhancing lesions of the central nervous system (CNS) in patients suffering from acquired immunodeficiency syndrome. We report a case of glioblastoma multiforme (GBM) in a 29-year-old man with
Highly active antiretroviral therapy: progress and pitfalls [editorial; comment]: J Pediatr. 1999 Dec;135(6):655-7. Unique Identifier : AIDSLINE MED/20054602; Wood LV
Clinical and immuno-virologic characterization of the efficacy of stavudine, lamivudine, and indinavir in human immunodeficiency virus infection [see comments]: Unique Identifier : AIDSLINE MED/20054608; Vigano A; Dally L; Bricalli D; Sala N; Pirillo M; Saresella M; Trabattoni D; Vella S; Clerici M; Principi N; Clinical, virologic, and immunologic outcomes were analyzed in children with vertically transmitted human immunodeficiency virus (HIV) infection (n = 25) and clinical symptoms and evidence of immunosuppression to establish the efficacy of 18 months
Will the changing face of HIV/AIDS affect the Ryan White CARE Act reauthorization vote?: J Natl Med Assoc. 1999 Oct;91(10):543-4. Unique Identifier : AIDSLINE MED/20067243; Shervington WW; National Medical Association, Washington, DC 20001, USA.
Seroprevalence of CMV antibodies in a blood donor population and premature neonates in the south-central Taiwan.: Kao Hsiung I Hsueh Ko Hsueh Tsa Chih. 1999 Oct;15(10):603-10. Unique Identifier : AIDSLINE MED/20071363; Lu SC; Chin LT; Wu FM; Hsieh GJ; Haung SP; Chen JC; Chang AC; Hsieh WK; Chen BH; Tainan Blood Center, Chinese Blood Services Foundation.; Infection of cytomegalovirus ( CMV ) via contaminated blood may endanger immunocompromised patients that require transfusion therapy. The aim of this study is to determine the prevalence of CMV antibodies in the blood donor pop
The impact of competing subsistence needs and barriers on access to medical care for persons with human immunodeficiency virus receiving care in the United States.: Med Care. 1999 Dec;37(12):1270-81. Unique Identifier : AIDSLINE MED/20066591; Cunningham WE; Andersen RM; Katz MH; Stein MD; Turner BJ; Crystal S; Zierler S; Kuromiya K; Morton SC; St. Clair P; Bozzette SA; Shapiro MF; Department of Medicine, School of Medicine, University of; California, Los Angeles, USA. wcunnig@medicine.medsch.ucla.edu; OBJECTIVES: To examine whether competing subsistence needs and other barriers are associated with poorer access to medical care among persons infected with human immunodeficiency virus (HIV), using self-reported data. DESIGN: Survey of a nationally representative sample of 2,864 adults receiving HIV care. MAIN INDEPEN
Effect of enhanced prenatal and HIV-focused services for pregnant women who are infected by human immunodeficiency virus on emergency department use.: Med Care. 1999 Dec;37(12):1308-19. Unique Identifier : AIDSLINE MED/20066594; Newschaffer CJ; Zhang D; Hauck WW; Fanning T; Turner BJ; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 61205, USA. cnewscha@jhsph.edu; OBJECTIVES: This study examines whether the receipt of enhanced prenatal or human immunodeficiency virus (HIV) medical services is associated with in-pregnancy emergency department (ED) utilization by HIV-infected women. METHODS: Medicaid and vital statistics records were linked for 1,826 women who are infected by HIV
[Prevention, safety and prophylactic measures in occupational HIV infection in Italy, the European Union and the USA]: Med Lav. 1999 Sep-Oct;90(5):681-92. Unique Identifier : AIDSLINE MED/20064340; Papacchini M; Delle Piane R; Palmi S; Tomao P; Istituto Superiore per la Prevenzione e la Sicurezza sul Lavoro; (ISPESL-DIPIA), Monteporzio Catone, Roma.; Numerous guidelines have been issued by Public Health institutions and related authorities in the last few years for the prevention of HIV infection among occupationally exposed workers. Our study was aimed at comparing the regulations and guidelines on this topic that have recently been adopted by Western countries,
PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner.: Mol Cell Biol. 1999 Dec;19(12):8136-45. Unique Identifier : AIDSLINE MED/20036771; Jiang H; Lu H; Schiltz RL; Pise-Masison CA; Ogryzko VV; Nakatani Y; Brady JN; Virus Tumor Biology Section, Laboratory of Receptor Biology and; Gene Expression, Division of Basic Sciences, National Cancer; Institute, National Institutes of Health, Bethesda, Maryland; 20892, USA.; Recent studies have shown that the p300/CREB binding protein (CBP)-associated factor (PCAF) is involved in transcriptional activation. PCAF activity has been shown strongly associated with histone acetyltransferase (HAT) activity. In this report, we present evidence for a HAT-independent transcription function that is
Case report. Histoplasmosis in an AIDS paediatric patient [letter]: Mycoses. 1999;42(9-10):567-9. Unique Identifier : AIDSLINE MED/20060288; Cimerman S; Sokolowski W; Goncalves SE; Lins MS; Colombo AL; Histoplasmosis has been little reported among HIV-infected children. We report a case of a 4-year old boy with AIDS who presented with disseminated histoplasmosis diagnosed by lung biopsy. The patient had a good clinical response to amphotericin B followed by itraconazole oral solution.
Images in clinical medicine. Histoplasma capsulatum in a peripheral- blood smear.: N Engl J Med. 2000 Jan 6;342(1):28. Unique Identifier : AIDSLINE MED/20074116; Edelman M; Mckitrick J; Montefiore Medical Center, Bronx, NY 10467, USA.
West Nile viral encephalitis in an HIV-positive woman in New York [letter]: N Engl J Med. 2000 Jan 6;342(1):59-60. Unique Identifier : AIDSLINE MED/20074128; Szilak I; Minamoto GY
A novel nuclear export activity in HIV-1 matrix protein required for viral replication.: Nature. 1999 Dec 9;402(6762):681-5. Unique Identifier : AIDSLINE MED/20067965; Dupont S; Sharova N; DeHoratius C; Virbasius CM; Zhu X; Bukrinskaya AG; Stevenson M; Green MR; Howard Hughes Medical Institute and Program in Molecular Medicine; at the University of Massachusetts Medical Center, Worcester; 01605, USA.; An important aspect of the pathophysiology of human immunodeficiency virus type-1 (HIV-1) infection is the ability of the virus to replicate in non-dividing cells. HIV-1 matrix (MA), the amino-terminal domain of the Pr55 gag polyprotein (Pr55), bears a nuclear localization signal that promotes localization of the vira
Does HHV-8 have a protective role on the development of HIV encephalopathy? Italian HIV-Seroconversion Study.: Neurology. 1999 Dec 10;53(9):2032-6. Unique Identifier : AIDSLINE MED/20066760; Rezza G; Dorrucci M; Stat D; Andreoni M; Arpino C; De Luca A; Monini P; Nicastri E; Alliegro MB; Pezzotti P; Ensoli B; AIDS & STD Unit, Istituto Superiore di Sanita, Rome, Italy.; g.rezza@iss.it; OBJECTIVE: To evaluate risk factors for HIV encephalopathy and whether Kaposi s sarcoma (KS) and coinfection with human herpesvirus 8 (HHV-8) protect against this disease in a cohort of HIV seroconverters. METHODS: Individuals with known dates of HIV seroconversion belonging to different HIV exposure categories (intra
False cultural assumptions: a bar to effective communication.: Nurs Times. 1999 Aug 11-17;95(32):42-3. Unique Identifier : AIDSLINE MED/20071537; Downes M
Hepatitis C: a danger to healthcare workers.: Nurs Forum. 1999 Apr-Jun;34(2):23-8. Unique Identifier : AIDSLINE MED/20071521; Dillman CM; Drug Addiction Services of Hawaii, Honolulu, USA.; There is no vaccine to prevent hepatitis C. The disease has infected more than 4 million people in the United States . Up to 10,000 people in the United States will die annually from the disease and that number will triple by the year 2010 (more than AIDS) (National Institutes of Health
Mucocutaneous manifestations of HIV infection in 91 children born to HIV-seropositive women.: Pediatr Dermatol. 1999 Sep-Oct;16(5):359-63. Unique Identifier : AIDSLINE MED/20040578; Wananukul S; Thisyakorn U; Department of Pediatrics, Chulalongkorn University, Bangkok,; Thailand.; We examined 91 children under the age of 13 years with definite HIV infection born to HIV-seropositive women. The clinical spectrum of HIV infection in children younger than 13 years who are born to HIV-infected mothers was revised in 1994 into four clinical categories: category N (not symptomatic), category A (mildly
RSV infection in infants and young children. What's new in diagnosis, treatment, and prevention?: Postgrad Med. 1999 Dec;106(7):97-9, 103-4, 107-8 passim. Unique Identifier : AIDSLINE MED/20076968; Baker KA; Ryan ME; Department of Pediatrics, Penn State Geisinger Health System,; Danville, USA.; RSV is the most important respiratory pathogen in infants and young children. About 1% of primary RSV infections result in hospitalization. The virus is spread by large droplets of secretions or contact with contaminated secretions. Infants infected with RSV may demonstrate poor feeding, rhinorrhea, apnea, lethargy, w
[Necrotizing and granulomatous Cryptococcus neoformans lymphadenitis in an HIV positive patient (letter)]: Presse Med. 1999 Nov 27;28(37):2039-40. Unique Identifier : AIDSLINE MED/20073405; Moukassa D; Leroy X; Ibara JR; Mounkassa B; Tsimba-Nsonda A; Kokolo J
[Treatment of visceral leishmaniasis: recent modalities]: Presse Med. 1999 Nov 27;28(37):2057-66. Unique Identifier : AIDSLINE MED/20073413; Gangneux JP; Laboratoire de Parasitologie-Mycologie, Hopital Saint-Louis,; Paris.; AN ENDEMIC DISEASE: Visceral leishmaniasis is an endemic disease in 47 countries and continues to be a difficult therapeutic challenge. The emergence of Leishmania strains resistant to pentavalent antimony derivatives and the growing incidence of visceral leishmaniasis among AIDS patients in the Mediterranean area emp
[Managing HIV infection. 2 new aspects]: Presse Med. 1999 Nov 27;28 Suppl 3:11-4. Unique Identifier : AIDSLINE MED/20073394; Katlama C; Service Pr. Bricaire, Groupe Hospitalier Pitie-Salpetriere,; Paris.; PROTEASE SPARING REGIMEN: Due to the problems of tolerance an acceptability of tritherapy regimens, generally composed of 2 nucleosidic reverse transcription inhibitors (NRTI) and a protease inhibitor (PI), it might be beneficial to use a protease sparing regimen replacing the PI by a third antiretroviral agent. HIV/H
[Toxicity of antiretroviral drugs]: Presse Med. 1999 Nov 27;28 Suppl 3:35-6. Unique Identifier : AIDSLINE MED/20073400; Lallemand F; METABOLIC DISORDERS: Lactic acidosis is one of the metabolic disorders provoked by antiretorviral drugs. Incidence, particularly cases of mild acidosis, appears to be rising. Symptoms are generally nonspecific. Early detection is based on history taking, physical examination, assay of arterial blood lactates. Disconti
Chronic pancreatic alterations in AIDS patients.: Pancreas. 1999 Nov;19(4):335-8. Unique Identifier : AIDSLINE MED/20012683; Evrard S; Van Laethem JL; Urbain D; Deviere J; Cremer M; Department of Gastroenterology, Erasme and St-Pierre University; Hospitals, Brussels, Belgium.; Patients with acquired immunodeficiency syndrome (AIDS) can develop biliary and pancreatic disorders, like sclerosing cholangitis and acute pancreatitis. Chronic pancreatic changes are rare and only poorly described. In this study, we report our endoscopic retrograde cholangiopancreatography (ERCP) findings in 20 pati
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13962-6. Unique Identifier : AIDSLINE MED/20040659; Yoshimoto T; Tsutsui H; Tominaga K; Hoshino K; Okamura H; Akira S; Paul WE; Nakanishi K; Department of Immunology, Institute for Advanced Medical; Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501; Japan.; IL-18 is a proinflammatory cytokine that plays an important role in natural killer cell activation and T helper 1 (Th1) cell responses. Mast cells and basophils are major inducers and effectors of allergic inflammation. Here we show that basophils and mast cells derived by culture of bone marrow cells with IL-3 for 10
Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV.: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14013-8. Unique Identifier : AIDSLINE MED/20040668; Garaci E; Caroleo MC; Aloe L; Aquaro S; Piacentini M; Costa N; Amendola A; Micera A; Calio R; Perno CF; Levi-Montalcini R; Department of Experimental Medicine, University of Rome Tor; Vergata, 00133 Rome, Italy.; Nerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor
Immunization with live attenuated simian immunodeficiency virus induces strong type 1 T helper responses and beta-chemokine production.: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14031-6. Unique Identifier : AIDSLINE MED/20040671; Gauduin MC; Glickman RL; Ahmad S; Yilma T; Johnson RP; Division of Immunology, New England Regional Primate Research; Center and Harvard Medical School, Southborough, MA 01772, USA.; Immunization with live attenuated simian immunodeficiency virus (SIV) strains has proved to be one of the most effective strategies to induce protective immunity in the SIV/macaque model. To better understand the role that CD4(+) T helper responses may play in mediating protection in this model, we characterized SIV-s
Emergence of a highly pathogenic simian/human immunodeficiency virus in a rhesus macaque treated with anti-CD8 mAb during a primary infection with a nonpathogenic virus.: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14049-54. Unique Identifier : AIDSLINE MED/20040674; Igarashi T; Endo Y; Englund G; Sadjadpour R; Matano T; Buckler C; Buckler-White A; Plishka R; Theodore T; Shibata R; Martin M; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892, USA.; Although simian/human immunodeficiency virus (SHIV) strain DH12 replicates to high titers and causes immunodeficiency in pig-tailed macaques, virus loads measured in SHIV(DH12)-infected rhesus monkeys are consistently 100-fold lower and none of 22 inoculated animals have developed disease. We previously reported that
Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.: Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14336-41. Unique Identifier : AIDSLINE MED/20056245; Marassi FM; Ma C; Gratkowski H; Straus SK; Strebel K; Oblatt-Montal M; Montal M; Opella SJ; Department of Chemistry, University of Pennsylvania,; Philadelphia, PA 19104, USA.; Vpu is an 81-residue membrane protein encoded by the HIV-1 genome. NMR experiments show that the protein folds into two distinct domains, a transmembrane hydrophobic helix and a cytoplasmic domain with two in-plane amphipathic alpha-helices separated by a linker region. Resonances in one-dimensional solid-state NMR sp
Specific therapy regimes could lead to long-term immunological control of HIV.: Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14464-9. Unique Identifier : AIDSLINE MED/20056267; Wodarz D; Nowak MA; Institute for Advanced Study, Olden Lane, Princeton, NJ 08540,; USA. wodarz@ias.edu; We use mathematical models to study the relationship between HIV and the immune system during the natural course of infection and in the context of different antiviral treatment regimes. The models suggest that an efficient cytotoxic T lymphocyte (CTL) memory response is required to control the virus. We define CTL me
Soluble complexes of regulated upon activation, normal T cells expressed and secreted (RANTES) and glycosaminoglycans suppress HIV-1 infection but do not induce Ca(2+) signaling.: Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14499-504. Unique Identifier : AIDSLINE MED/20056273; Burns JM; Lewis GK; DeVico AL; Division of Basic Science, Institute of Human Virology,; University of Maryland, Baltimore, MD 21201, USA.; Chemokines comprise a family of low-molecular-weight proteins that elicit a variety of biological responses including chemotaxis, intracellular Ca(2+) mobilization, and activation of tyrosine kinase signaling cascades. A subset of chemokines, including regulated upon activation, normal T cell expressed and secreted (R
[Epidemiology of multi-drug resistant tuberculosis in AIDS]: Recenti Prog Med. 1999 Oct;90(10):515-21. Unique Identifier : AIDSLINE MED/20060321; Moro ML; Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Roma.
[CNS-infections in HIV patients]: Ther Umsch. 1999 Nov;56(11):670-4. Unique Identifier : AIDSLINE MED/20064078; Malinverni R; Furrer H; HIV-Sprechstunde, Medizinische Universitatspoliklinik Bern.; Neurological manifestations are frequent in patients with AIDS. Many neurological disorders have disappeared with the advent of highly active antiretroviral combination therapies. We can speculate that some of these disorders may reappear in patients under antiretroviral therapy, possibly with different clinical manif
The epidemiology of virus transmission by plasma derivatives: clinical studies verifying the lack of transmission of hepatitis B and C viruses and HIV type 1.: Transfusion. 1999 Nov-Dec;39(11-12):1160-8. Unique Identifier : AIDSLINE MED/20067730; Tabor E; Office of Blood Research and Review, Food and Drug; Administration, Bethesda, Maryland, USA.; During the past 50 years, most US-licensed plasma derivatives have maintained an impressive record of not transmitting HBV, HCV, or HIV Albumin (50-year history) has never transmitted these viruses. PPF (40-year history) transmitted HBV on only one occasion, which was associated with a design flaw in one manufacturing
Sensitivity and specificity of human T-lymphotropic virus (HTLV) types I and II polymerase chain reaction and several serologic assays in screening a population with a high prevalence of HTLV-II.: Transfusion. 1999 Nov-Dec;39(11-12):1185-93. Unique Identifier : AIDSLINE MED/20067733; Liu H; Shah M; Stramer SL; Chen W; Weiblen BJ; Murphy EL; Department of Laboratory Medicine, University of California San; Francisco, 94143-0884, USA.; BACKGROUND: Since 1988, all blood donations in the United States have been screened for antibodies to human T-lymphotropic virus type I (HTLV-I). However, the sensitivity of current serologic tests for the detection of HTLV type II (HTLV-II) antibodies and the diagnostic utility of dir
Thymic transplantation in miniature swine. I. Development and function of the "thymokidney" [see comments]: Transplantation. 1999 Dec 15;68(11):1684-92. Unique Identifier : AIDSLINE MED/20076057; Yamada K; Shimizu A; Ierino FL; Utsugi R; Barth RN; Esnaola N; Colvin RB; Sachs DH; Transplantation Biology Research Center, Department of Pathology,; Massachusetts General Hospital, Boston 02129, USA.; BACKGROUND: Previous studies in our laboratory have demonstrated the importance of the thymus for rapid and stable tolerance induction in an allotransplant model. The focus of the present study was to explore the feasibility of autologous thymic transplantation to produce a new transplantable organ (thymokidney) and t
Roles of CD4+ and CD8+ T cells in discordant skin xenograft rejection.: Transplantation. 1999 Dec 15;68(11):1721-7. Unique Identifier : AIDSLINE MED/20076062; Uchida T; Tomita Y; Anzai K; Zhang QW; Yoshikawa M; Kishihara K; Nomoto K; Yasui H; Department of Cardiovascular Surgery, Faculty of Medicine, Kyushu; University, Fukuoka, Japan.; An essential role of murine CD4+ T cells in immune reactivity and skin graft rejection in discordant xenogeneic combinations have been reported. Our study was conducted to further clarify the roles of CD4+ and CD8+ T cells in discordant skin xenograft rejection, by using CD4 and CD8 knockout [C57BL/6 Cr Slc (B6; H-2b)
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells.: Unique Identifier : AIDSLINE MED/20032069; Cotter MA 2nd; Robertson ES; Viruses that establish latent infection must maintain their DNA in the host nucleus through many cellular generations. Here we identify a novel mechanism by which the gammaherpesvirus Kaposi s sarcoma-associated herpesvirus (KSHV) may achieve this persistence in latently infected body cavity-based lymphoma (BCBL) cell
Relationship between productive HIV-1 infection of macrophages and CCR5 utilization.: Virology. 1999 Nov 25;264(2):278-88. Unique Identifier : AIDSLINE MED/20032071; Hung CS; Pontow S; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri, 63110, USA.; HIV-1 isolates exhibit specificity for infection of immortalized T-cell lines and macrophages. The distinct cellular tropisms have been attributed to expression of coreceptors CXCR4 or CCR5, respectively. However, it is unclear whether or not other tissue-specific determinants regulate entry. The current study uses a
Frequency of CD8(+) T lymphocytes specific for lytic and latent antigens of Epstein-Barr virus in healthy virus carriers.: Virology. 1999 Nov 25;264(2):289-97. Unique Identifier : AIDSLINE MED/20032072; Benninger-Doring G; Pepperl S; Deml L; Modrow S; Wolf H; Jilg W; Institut fur Medizinische Mikrobiologie und Hygiene,; Universitat Regensburg, Regensburg, D-93053, Germany.; wolfgang.jilg@klinik.uni-regensburg.de; We investigated CD8(+) T cell frequencies of five different Epstein-Barr virus-specific cytotoxic T lymphocyte epitopes located within proteins of the replicative cycle and the latent state in healthy long-term virus carriers with IFN-gamma enzyme-linked immunospot assay. Frequencies of the HLA-A3-restricted epitope R
Nonproductive human immunodeficiency virus type 1 infection of human fetal astrocytes: independence from CD4 and major chemokine receptors.: Virology. 1999 Nov 25;264(2):370-84. Unique Identifier : AIDSLINE +; Sabri F; Tresoldi E; Di Stefano M; Polo S; Monaco MC; Verani A; Fiore JR; Lusso P; Major E; Chiodi F; Scarlatti G; Microbiology and Tumorbiology Center, Karolinska Institute,; Doktorsringen 13, Stockholm, 17177, Sweden.; Human immunodeficiency virus type 1 (HIV-1) infection of the brain is associated with neurological manifestations both in adults and in children. The primary target for HIV-1 infection in the brain is the microglia, but astrocytes can also be infected. We tested 26 primary HIV-1 isolates for their capacity to infect h
Enhanced HIV-1 replication by chemokines constitutively expressed in secondary lymphoid tissues.: Virology. 1999 Nov 25;264(2):422-6. Unique Identifier : AIDSLINE MED/20032082; Nagira M; Sato A; Miki S; Imai T; Yoshie O; Shionogi Institute for Medical Science, Osaka, 566-0022, Japan.; Persistent infection of human immunodeficiency virus (HIV) takes place in the secondary lymphoid tissues even during clinically latent stages. The CC chemokines secondary lymphoid tissue chemokine (SLC) and EBI1-ligand chemokine (ELC) are constitutively expressed in the secondary lymphoid tissues. They share CCR7 expr
Development of bivalent (B/E) vaccines able to neutralize CCR5-dependent viruses from the United States and Thailand.: Virology. 1999 Dec 5;265(1):1-9. Unique Identifier : AIDSLINE MED/20072949; Berman PW; Huang W; Riddle L; Gray AM; Wrin T; Vennari J; Johnson A; Klaussen M; Prashad H; Kohne C; deWit C; Gregory TJ; Genentech, Inc., South San Francisco, California, 94080, USA.; pwb@vaxgen.com; Recombinant envelope glycoproteins prepared from a subtype B (MN) strain and a subtype E (CM244) strain of HIV-1 were combined to create a bivalent vaccine (B/E) effective against viruses circulating in the United States and Asia. Combining the two antigens resulted in formulations tha
[Approach to the identification of virus receptor]: Uirusu. 1999 Jun;49(1):1-9. Unique Identifier : AIDSLINE MED/20016649; Okuma K; Yanagi Y; Department of Virology, Graduate School of Medical Sciences,; Kyushu University, Fukuoka, Japan.
[Model of viral infection in SCID mice: SCID-hu mouse and hu-PBL-SCID mouse]: Uirusu. 1999 Jun;49(1):33-9. Unique Identifier : AIDSLINE MED/20016653; Koyanagi Y; Department of Virology, Tohoku University School of Medicine,; Sendai.
[Theories on the mode of action of desensitization]: Wien Med Wochenschr. 1999;149(14-15):415-20. Unique Identifier : AIDSLINE MED/20051674; Klimek L; Reske-Kunz AB; Saloga J; Hals-, Nasen-, Ohren-Universitatsklinik Mainz, Deutschland.; klimek@hno.klinik.uni-mainz.de; Specific immunotherapy (SIT) has been practised successfully for about 80 years. In classic immunotherapy, an allergen-extract is repeatedly injected subcutaneously in increasing doses. A large number of clinically controlled studies have proved the efficacy of this kind of immunotherapy, while its mode of action is n
Measles elimination: progress and challenges.: Vaccine. 1999 Oct 29;17 Suppl 3:S47-52. Unique Identifier : AIDSLINE MED/20027647; Cutts FT; Henao-Restrepo A; Olive JM; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, Keppel Street, London, UK.; f.cutts@lshtm.ac.uk; The accelerating progress in reducing measles incidence and mortality in many parts of the world has led to calls for its global eradication during the next 10-15 years. Three regions have established goals of elimination of indigenous transmission of measles. The strategy used in the Americas of a mass catchup camp
Behcet's syndrome. The Cerrahpasa experience. Members of the Behcet's Syndrome Research Centre.: Adv Exp Med Biol. 1999;455:135-40. Unique Identifier : AIDSLINE MED/20067441; Yazici H; Fresko I; Hamuryudan V; Mat C; Melikoglu M; Ozyazgan Y; Tuzun Y; Yurdakul S; University of Istanbul, Turkey.; Behcet s syndrome (BS) is a systemic vasculitis of unknown etiology. There are several reasons for doubting a primary autoimmune pathogenesis of this condition. Recent information suggests evidence for genetic anticipation. Although there is heightened inflammatory activity, as exemplified by the pathergy reaction, wo
An overview of classic Kaposi's sarcoma in Greece.: Adv Exp Med Biol. 1999;455:503-6. Unique Identifier : AIDSLINE MED/20067496; Stratigos JD; Katoulis AC; Stavrianeas NG; National University of Athens, Department of Dermatology and; Venereology, A. Sygros Hospital, Greece.; Classic Kaposi s sarcoma (CKS) is a rare tumor affecting mainly the elderly and running a chronic and indolent course. CKS in Greece is not uncommon with an estimated annual incidence of 0.47/1000,000 population, representing 1.35%
Impact of protease inhibitors on the outcome of human immunodeficiency virus-infected patients with chronic diarrhea.: Am J Gastroenterol. 1999 Dec;94(12):3553-9. Unique Identifier : AIDSLINE MED/20072334; Bini EJ; Cohen J; Division of Gastroenterology, New York VA Medical Center, NY; 10010, USA.; OBJECTIVE: The effect of protease inhibitors on the outcome of chronic HIV-related diarrhea is unknown. The aim of this study was to compare the response to treatment of chronic HIV-related diarrhea, recurrence of diarrhea, and survival in a large cohort of individu
Chronic hepatitis C infection in patients with end stage renal disease: characterization of liver histology and viral load in patients awaiting renal transplantation.: Am J Gastroenterol. 1999 Dec;94(12):3576-82. Unique Identifier : AIDSLINE MED/20072338; Sterling RK; Sanyal AJ; Luketic VA; Stravitz RT; King AL; Post AB; Mills AS; Contos MJ; Shiffman ML; Department of Pathology, Medical College of Virginia Commonwealth; University, Richmond 23298, USA.; OBJECTIVES: Hepatitis C virus (HCV) is common in patients with end stage renal disease (ESRD) awaiting renal transplantation (RT). However, few data are available on the liver histology and viral titer in these patients relative to patients with HCV and normal renal function. The aims of this study were to assess live
Biochemical and viral response to consensus interferon (CIFN) therapy in chronic hepatitis C patients: effect of baseline viral concentration. Consensus Interferon Study Group.: Am J Gastroenterol. 1999 Dec;94(12):3583-8. Unique Identifier : AIDSLINE MED/20072339; Jensen DM; Krawitt EL; Keeffe EB; Hollinger FB; James SP; Mullen K; Everson GT; Hoefs JC; Fromm H; Black M; Foust RT; Pimstone NR; Heathcote EJ; Albert D; Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois; 60612, USA.; OBJECTIVE: The effect of baseline viral concentration on response was assessed as part of a multicenter phase 3 trial evaluating the safety and efficacy of CIFN therapy for chronic HCV infection. METHODS: Patients (n = 472) received either CIFN 9 microg or IFN alpha-2b 3 MU subcutaneously t.i.w. for 24 wk, followed by
Decrease in the prevalence of IL-4-producing CD4+ T cells in patients with advanced stage of primary biliary cirrhosis.: Am J Gastroenterol. 1999 Dec;94(12):3589-94. Unique Identifier : AIDSLINE MED/20072340; Sekiya H; Komatsu T; Isono E; Furukawa M; Matsushima S; Yamaguchi N; Yamauchi K; Hayashi N; Clinical Research Institute, National Yokohama Hospital,; Kanagawa, Japan.; OBJECTIVE: To elucidate the precise immunological features in primary biliary cirrhosis (PBC), we examined the relative prevalence of CD4+ T cells in either symptomatic PBC (sPBC) or asymptomatic PBC patients (aPBC), and furthermore, these results were compared with their histological features. METHODS: Cytokine synth
Hypercalcemia associated with infection by Cryptococcus neoformans and Coccidioides immitis.: Am J Med Sci. 1999 Dec;318(6):419-23. Unique Identifier : AIDSLINE MED/20081914; Ali MY; Gopal KV; Llerena LA; Taylor HC; Division of Infectious Disease and Endocrinology, Fairview; General Hospital, Cleveland Clinic Health System, Ohio, USA.; BACKGROUND: Of the 13 reported cases of hypercalcemia associated with fungal infection, 1 was caused by Cryptococcus neoformans and probably mediated by increased levels of 1,25-dihydroxyvitamin D [1,25(OH)2D]. Eight others were associated with Coccidioides immitis, of which only 2 had measured 1,25(OH)2D levels; in b
Concepts of time in clinical research.: Ann Intern Med. 2000 Jan 4;132(1):37-44. Unique Identifier : AIDSLINE MED/20075963; Samet JM; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, Maryland 21205, USA.; The study of events in time is fundamental to biomedical research and public health surveillance. Clinicians have an intuitive appreciation for the relevance of time to health and disease, and patients invariably ask questions relating to time for which clinicians need answers. An appreciation of the picture of health
[Intralesional injection of vinblastine in treatment of laryngeal Kaposi sarcoma associated with AIDS]: Ann Otolaryngol Chir Cervicofac. 1999 Oct;116(5):291-4. Unique Identifier : AIDSLINE MED/20038888; Gras R; Moulin G; Giovanni A; Chagnaud C; Triglia JM; Zanaret M; Federation d'ORL, CHU Timone, Marseille.; Kaposi s sarcoma (KS), is the most frequent malignant neoplasm associated with acquired immunodeficiency syndrome (AIDS). Classically arising in the skin, mucosal lesions are seen in 50 percent in oral cavity. KS rarely involves the larynx (37 cases have been reported in the world literature), when KS occurs in the la
Immunological manifestations of HIV-infected children.: Ann Trop Paediatr. 1999 Mar;19(1):3-7. Unique Identifier : AIDSLINE MED/20073447; Eley BS; Hughes J; Potgieter S; Keraan M; Burgess J; Hussey GD; Department of Paediatrics and Child Health, University of Cape; Town, South Africa.; This cross-sectional study of stable HIV-infected children was designed to document the immunological manifestations of paediatric HIV infection and to determine whether inexpensive markers of immunosuppression could be identified. Investigations included lymphocyte count and subset analysis, levels of total protein,
Lesbians' sexual history with men: implications for taking a sexual history.: Arch Intern Med. 1999 Dec 13-27;159(22):2730-6. Unique Identifier : AIDSLINE MED/20064634; Diamant AL; Schuster MA; McGuigan K; Lever J; Department of Medicine, University of California, Los Angeles; 90095, USA. adiamant@ucla.edu; BACKGROUND: Health care providers may not solicit a comprehensive sexual history from lesbian patients because of provider assumptions that lesbians have not been sexually active with men. We performed this study to assess whether women who identify themselves as lesbians have a history of sexual activities with men t
Presence of human herpesvirus 8 DNA sequences in renal transplantation-associated pleural Kaposi sarcoma.: Arch Pathol Lab Med. 1999 Dec;123(12):1269-73. Unique Identifier : AIDSLINE MED/20050036; Gomez-Roman JJ; Ocejo-Vinyals JG; Sanchez-Velasco P; Leyva-Cobian F; Val-Bernal JF; Department of Anatomical Pathology, Marques de Valdecilla; University Hospital, Instituto Nacional de la Salud, Medical; Faculty, University of Catabria, Santander, Spain.; OBJECTIVE: To describe one case of symptomatic skin and pleural Kaposi sarcoma (KS) associated with kidney transplantation. Diagnosis was supported by morphologic study and human herpesvirus 8 (HHV-8) detection in both tissues. Pulmonary involvement was not present. DESIGN: The presence of HHV-8 DNA sequences was prov
HIV case loads of Australian GPs. Results of the national survey.: Aust Fam Physician. 1999 Sep;28(9):966-70. Unique Identifier : AIDSLINE MED/20024546; Kirkman M; Bartos M; Scott M; Australian Research Centre in Sex, Health and Society, La Trobe; University, Melbourne. M.Kirkman@latrobe.edu.au; BACKGROUND: This paper presents national survey data concerning the management of HIV positive patients by GPs. OBJECTIVE: To examine the extent and nature of GPs involvement in the management of patients with HIV/AIDS; to identify their needs for education and support. DISCUSSION: Some GPs have never been consulted
Thalidomide as an emerging immunotherapeutic agent.: Immunol Today. 1999 Dec;20(12):538-40. Unique Identifier : AIDSLINE MED/20031579; Marriott JB; Muller G; Dalgleish AG; Division of Oncology, Dept of Cellular and Molecular Sciences, St; George's Hospital Medical School, Cranmer Terrace, London SW17; 0RE, UK. jmarriot@sghms.ac.uk
Epitope vaccine: a new strategy against HIV-1 [letter]: Immunol Today. 1999 Dec;20(12):588-9. Unique Identifier : AIDSLINE MED/20031588; Chen YH; Xiao Y; Yu T; Dierich MP
Anterior chamber-associated immune deviation.: Chem Immunol. 1999;73:59-71. Unique Identifier : AIDSLINE MED/20058079; Niederkorn JY; Department of Ophthalmology, University of Texas Southwestern; Medical Center, Dallas, USA. jniede@mednet.swmed.edu
[The genomic sequences of the human herpesvirus 8 in biological samples from HIV-positive and -negative subjects in Sicily]: Ann Ig. 1999 Nov-Dec;11(6):507-9. Unique Identifier : AIDSLINE MED/20064241; Viviano E; Gallo E; Bongiorno MR; Romano N; Dipartimento di Igiene e Microbiologia, Universita degli Studi; di Palermo.
Pharmacokinetics of rifabutin in HIV-infected patients with or without wasting syndrome.: Br J Clin Pharmacol. 1999 Nov;48(5):704-11. Unique Identifier : AIDSLINE MED/20063672; Gatti G; Di Biagio A; De Pascalis CR; Guerra M; Bassetti M; Bassetti D; First Department of Infectious Diseases, University of Genoa,; Genoa, Italy. gigatti@smartino.ge.it; AIMS: The purpose of the study was to compare the pharmacokinetic parameters of rifabutin obtained in a group of patients without wasting syndrome (NWS) with those obtained in a group with wasting syndrome (WS). METHODS: A single dose of 300 mg rifabutin was administered in the fasting state to the patients in both st
Pharmacokinetics of efavirenz (EFV) alone and in combination therapy with nelfinavir (NFV) in HIV-1 infected patients.: Br J Clin Pharmacol. 1999 Nov;48(5):712-5. Unique Identifier : AIDSLINE MED/20063673; Villani P; Regazzi MB; Castelli F; Viale P; Torti C; Seminari E; Maserati R; Department of Pharmacology, IRCCS Policlinico S. Matteo. Pavia,; Italy.; AIMS: To define the pharmacokinetic profile of efavirenz (EFV) in HIV-1 infected patients, when administered alone or with nelfinavir (NFV). METHODS: Eleven HIV-positive patients, in steady-state treatment with EFV and 11 patients in steady-state trea
Global AIDS surveillance--Part I.: Wkly Epidemiol Rec. 1999 Nov 26;74(47):401-4. Unique Identifier : AIDSLINE MED/20065559
Anterior uveitis associated with intravenous cidofovir use in patients with cytomegalovirus retinitis.: Br J Ophthalmol. 1999 Oct;83(10):1153-8. Unique Identifier : AIDSLINE MED/20002155; Ambati J; Wynne KB; Angerame MC; Robinson MR; Current address: Retina Service, Massachusetts Eye and Ear; Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA; 02114, USA.; AIM: Intravenous cidofovir is used to treat cytomegalovirus ( CMV ) retinitis, and has been reported to cause anterior uveitis. Relations were sought between this complication and patient characteristics that might help predict
Influence of highly active antiretroviral therapy on the development of CMV disease in HIV positive patients at high risk for CMV disease.: Br J Ophthalmol. 1999 Oct;83(10):1186-9. Unique Identifier : AIDSLINE MED/20002162; Verbraak FD; Boom R; Wertheim-van Dillen PM; van den Horn GJ; Kijlstra A; de Smet MD; Department of Ophthalmology, Academic Medical Centre, University; of Amsterdam, Amsterdam, Netherlands.; BACKGROUND/AIMS: In the pre-HAART era, HIV positive patients with CD4+ cell counts below 50 cells x10(6)/l, and those with detectable cytomegalovirus ( CMV ) DNA in their peripheral blood, were considered to be at high risk for
Late onset of Leber's hereditary optic neuropathy in HIV infection [letter]: Br J Ophthalmol. 1999 Oct;83(10):1204-5. Unique Identifier : AIDSLINE MED/20095795; Luke C; Cornely OA; Fricke J; Lehrer E; Bartz-Schmidt KU
Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2 year prospective study.: Unique Identifier : AIDSLINE MED/20002038; Mitchell SM; Membrey WL; Youle MS; Obi A; Worrell S; Gazzard BG; Department of Ophthalmology, St Stephen's Centre, Chelsea and; Westminster Hospital, London.; BACKGROUND/AIMS: There have been several recent reports suggesting that the natural history of cytomegalovirus retinitis (CMVR) has been significantly modified with the development of highly active antiretroviral therapy (HAART). This 2 year prospective cohort study assesses the ef
How effective are complementary therapies for HIV and AIDs?--A systematic review.: Int J STD AIDS. 1999 Oct;10(10):629-35. Unique Identifier : AIDSLINE MED/20047453; Ozsoy M; Ernst E; Department of Complementary Medicine, School of Postgraduate; Medicine and Health Sciences, University of Exeter, UK.; Complementary treatments are often used by HIV-infected individuals. Yet little is known about their effectiveness. The aim of this systematic review was therefore to summarize the published evidence for or against the effectiveness of complementary therapies in HIV-positive people. A comprehensive literature search w
Update on the treatment of sexually transmitted infections in pregnancy--2.: Int J STD AIDS. 1999 Oct;10(10):636-42; quiz 642-3. Unique Identifier : AIDSLINE MED/20047454; Brocklehurst P; National Perinatal Epidemiology Unit, Radcliffe Infirmary,; Oxford, UK. Peter.brocklehurst@perinat.ox.ac.uk
Subtyping of high-level plasmid-mediated tetracycline resistant Neisseria gonorrhoeae isolated in Scotland between 1992 and 1998.: Unique Identifier : AIDSLINE MED/20047455; Beattie T; Moyes A; Patrizio C; Young H; Tetracycline resistant Neisseria gonorrhoeae (TRNG) contain a 25.2 MDa TetM plasmid encoding a 68 KDa cytoplasmic protein which confers high-level tetracycline resistance. The aim of this study was to subtype all TRNG isolated in Scotland between 1992 and 1998. Subtyping was performed by a polymerase chain reaction (P
Monitoring cytomegalovirus retinitis prevalence in an HIV-seropositive cohort: the assessment of improvements observed following the introduction of highly active antiretroviral triple therapy.: Int J STD AIDS. 1999 Oct;10(10):652-6. Unique Identifier : AIDSLINE MED/20047456; Hutchinson S; Courtney R; Mulcahy F; O'Connor M; Mullaney S; Kilbride R; Department of Ophthalmology, St James's Hospital, Dublin,; Ireland.; This paper concerns the ophthalmic assessment of patients with acquired immunodeficiency syndrome (AIDS) for a number of eye conditions and in particular cytomegalovirus ( CMV ) retinitis. CMV has been the most common opportuni
Sexually transmitted infections in the Russian Federation, the Baltic States and Poland.: Int J STD AIDS. 1999 Oct;10(10):657-8. Unique Identifier : AIDSLINE MED/20047457; Bingham JS; Waugh MA; Guy's & St Thomas' Hospital, London, UK.
The control and management of the sexually transmitted diseases: a comparison of the United Kingdom and the Russian Federation.: Int J STD AIDS. 1999 Oct;10(10):659-64. Unique Identifier : AIDSLINE MED/20047458; Renton AM; Borisenko KK; Tichonova LI; Akovbian VA; Department of Social Science and Medicine, Imperial College of; Science, Technology and Medicine, London, UK.; During the last 20 years, both the United Kingdom and the Russian Federation have seen changes to clinical services for sexually transmitted diseases (STDs) health systems and other mechanisms through which STDs are controlled. In the UK these changes followed the description of the ac
Syphilis and other sexually transmitted infections in the Russian Federation.: Int J STD AIDS. 1999 Oct;10(10):665-8. Unique Identifier : AIDSLINE MED/20047459; Borisenko KK; Tichonova LI; Renton AM; Russian Association against STDs (SANAM), Moscow, Russian; Federation.; The countries of the former Soviet Union are currently experiencing major epidemics of sexually transmitted infections (STIs). By 1997 rates of syphilis notification in the Russian Federation had risen to 277 per 100,000 total population, a 43-fold increase over 1989 levels, with rises proportionally larger among youn
Sexually transmitted infections in Estonia.: Int J STD AIDS. 1999 Oct;10(10):669-72. Unique Identifier : AIDSLINE MED/20047460; Poder A; Bingham JS; Department of Dermatology, Tartu University, Estonia.; Estonia , one of the Baltic countries, regained its independence in 1991, after the collapse of the USSR. This process led to great changes in every sphere of life--in politics, in the economy and in medicine. The service providing care for sexually transmitted infections (STIs) wa
Sexually transmitted diseases in Lithuania: some epidemiological and social aspects.: Unique Identifier : AIDSLINE MED/20047461; Lapinskaite GS; Bingham JS; The Republican Hospital for Skin and Venereal Diseases, Vilnius,; Lithuania.; With political, economical and social changes in Lithuania following the break-up of the Soviet Union, the health-care system has changed. The old Soviet system has been abandoned and it has taken time to re-establish a system under
HIV infection and sexually transmitted infections in Lithuania.: Int J STD AIDS. 1999 Oct;10(10):677-9. Unique Identifier : AIDSLINE MED/20047462; Chaplinskas S; Trechiokas A; Lithuanian AIDS Centre, Vilnius.; Lithuania is a small country with a population of 3.7 million. It has recently been released from the yoke of Soviet rule. HIV infection was first identified in 1988 and while the numbers of cases are small, the incidence is beginni
Epidemiology of syphilis and gonorrhoea in eastern Poland in the years 1988-1997.: Int J STD AIDS. 1999 Oct;10(10):680-4. Unique Identifier : AIDSLINE MED/20047463; Chodynicka B; Serwin AB; Janczylo-Jankowska M; Waugh MA; Department of Dermatology and Venereology, Medical Academy of; Bialystok, Poland.; Because of the sexually transmitted diseases (STDs) epidemic in the former Soviet Union and the possibility of a rise in early syphilis and gonorrhoea in the eastern region of Poland it seemed important to calculate the incidence ra
The name game: lamivudine-lamotrigine dispensing error presenting as human immunodeficiency virus-associated fever of unknown origin.: Int J STD AIDS. 1999 Oct;10(10):685-6. Unique Identifier : AIDSLINE MED/20047464; Fowler VG Jr; Hicks CB; Kirkland KB; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA. fowle003@mc.duke.edu
Hepatitis as the presenting feature of an HIV seroconversion illness.: Int J STD AIDS. 1999 Oct;10(10):687-8. Unique Identifier : AIDSLINE MED/20047465; Bramkamp GR; Holt RI; Bending JJ; Umasankar RS; Cooke RP; Department of Medicine, Eastbourne District General Hospital, UK.
Antiretroviral therapy in HIV infection: are we using resources appropriately and cost effectively?: Int J STD AIDS. 1999 Oct;10(10):689-91. Unique Identifier : AIDSLINE MED/20047466; Horn CK; Dodds R; Scott GR; Department of Genitourinary Medicine, Royal Infirmary of; Edinburgh NHS Trust, UK.; The provision of antiretroviral therapy to HIV-positive patients attending the Department of Genitourinary Medicine at the Royal Infirmary of Edinburgh was assessed, to examine whether clinicians were offering treatment in line with the departmental protocol. A total of 195 patients attended in 1998, of whom 169 fulfi
An audit of antiretroviral prescribing in HIV patients. Yorkshire Audit Group for HIV-related diseases.: Int J STD AIDS. 1999 Oct;10(10):692-3. Unique Identifier : AIDSLINE MED/20047467; Monteiro E; Department of Genitourinary Medicine, Leeds General Infirmary,; UK. e.f.monteiro@leeds.ac.uk
A case of cat scratch disease masquerading as lymphogranuloma venereum [letter]: Int J STD AIDS. 1999 Oct;10(10):694. Unique Identifier : AIDSLINE MED/20047468; Philpot CR
[Disseminated extrapulmonary tuberculosis with skin, lymph node and bone involvement]: An Med Interna. 1999 Oct;16(10):525-6. Unique Identifier : AIDSLINE MED/20071327; Gomez Rodriguez N; Ibanez Ruan J; Ferreiro Seoane JL; Sevillano Castano J; Servicio de Reumatologia, Centro Medico POVISA, Vigo.; Disseminated extrapulmonary tuberculosis is uncommon in no immunocompromised hosts. We described the case of a 68-year-old HIV seronegative man, who presented with a 5 months history of constitutional symptoms, generalized lymphadenopathy, evening fever, osteomyelitis of the left fibula and cutaneous lesions (papules
[The prognostic markers of HIV infection progression. A study of the p24 antigen in a cohort of 251 patients]: An Med Interna. 1999 Sep;16(9):447-50. Unique Identifier : AIDSLINE MED/20077356; Rubio Caballero M; Nogues Biau A; Falguera Sacrest M; Puig Ganau T; Servicio de Medicina Interna, Hospital Universitario Arnau de; Vilanova, Lleida.; BACKGROUND: Prospective study of AIDS or death progression in a cohort of 251 HIV infected patients whose time of seroconversion is unknown, with 2 main objectives: 1. To analyse plasma level p24 antigen as a marker of progression. 2. To evaluate stability of plasma levels of p24 antigen as a marker of progression. PA
[Bilateral round pneumonia and Q fever (letter)]: An Med Interna. 1999 Sep;16(9):488-9. Unique Identifier : AIDSLINE MED/20077367; Anton Aranda E; Marti Cabane J
[Invasive aspergillosis in a patient with human immunodeficiency virus infection (HIV) and relatively preserved immunity (letter)]: An Med Interna. 1999 Sep;16(9):489-90. Unique Identifier : AIDSLINE MED/20077368; Camafort M; Bronsoms J; Valles M; Pocar C; Garcia-Bragado F
Constitutive activation of STATs upon in vivo human immunodeficiency virus infection.: Blood. 1999 Dec 15;94(12):4202-9. Unique Identifier : AIDSLINE MED/20057673; Bovolenta C; Camorali L; Lorini AL; Ghezzi S; Vicenzi E; Lazzarin A; Poli G; AIDS Immunophatogenesis Unit, DIBIT, Division of Infectious; Diseases, Centro San Luigi, San Raffaele Scientific Institute,; Milan, Italy. bovolenta.chiara@hsr.it; Infection by the human immunodeficiency virus (HIV) either upregulates or downregulates the expression of several cytokines and interferons (IFNs) that use the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway for signal transduction. However, very little is known on the state of activat
The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.: Blood. 1999 Dec 15;94(12):4233-46. Unique Identifier : AIDSLINE MED/20057676; Salgia R; Quackenbush E; Lin J; Souchkova N; Sattler M; Ewaniuk DS; Klucher KM; Daley GQ; Kraeft SK; Sackstein R; Alyea EP; von Andrian UH; Chen LB; Gutierrez-Ramos JC; Pendergast AM; Griffin JD; Department of Medical Oncology, Division of Hematologic Oncology,; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA,; USA. ravi_salgia@dfci.harvard.edu; The chemokine stromal-derived factor-1alpha (SDF-1alpha) is a chemoattractant for CD34(+) progenitor cells, in vitro and in vivo. The receptor for SDF-1alpha, CXCR-4, is a 7 transmembrane domain receptor, which is also a coreceptor for human immunodeficiency virus (HIV). Here we show that transformation of hematopoiet
Role of vascular endothelial growth factor/vascular permeability factor in the pathogenesis of Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphomas.: Blood. 1999 Dec 15;94(12):4247-54. Unique Identifier : AIDSLINE MED/20057677; Aoki Y; Tosato G; Division of Hematologic Products, Center for Biologics Evaluation; and Research, Food and Drug Administration, Bethesda, MD, USA.; AOKI@CEBR.FDA.GOV; Primary effusion lymphomas (PELs), which are rare lymphomas associated with Kaposi s sarcoma-associated herpesvirus (or human herpesvirus-8) infection, present as malignant lymphomatous effusions in body cavities. Because PELs prefer liquid growth, we hypothesized that increased vascular permeability would be required
TT virus is present in a high frequency of Italian hemophilic patients transfused with plasma-derived clotting factor concentrates.: Blood. 1999 Dec 15;94(12):4333-6. Unique Identifier : AIDSLINE MED/20057686; Chen BP; Rumi MG; Colombo M; Lin YH; Ramaswamy L; Luna J; Liu JK; Prati D; Mannucci PM; Sentinel BioSciences, Inc, Palo Alto, CA, USA.; The prevalence of the blood-borne TT virus (TTV) in Italian hemophiliacs treated with different preparations of factor VIII was determined. Of the 178 hemophilic patients (mean age, 29 years), TTV-DNA was found in 123 (69%), in comparison to 22 of 100 (22%) blood donors (P
Interleukin 12 and psoriasis [editorial; comment]: Dermatology. 1999;199(2):101. Unique Identifier : AIDSLINE MED/20095762; de Rie MA
Effects of cyclosporin A on immune activation markers in patients with active psoriasis [see comments]: Dermatology. 1999;199(2):144-8. Unique Identifier : AIDSLINE MED/20025620; Economidou J; Barkis J; Demetriou Z; Avgerinou G; Psarra K; Degiannis D; Vareltzidis A; Katsambas A; Department of Dermatology-Venereology University of Athens,; Athens, Greece.; BACKGROUND: Psoriasis is a T-cell mediated autoimmune disease. The objective of this work was to investigate the presence of cellular and soluble activation molecules in the blood of patients with psoriasis, not responding to local treatment and to study the effect of cyclosporin A (CsA) on these markers. METHODS: Twe
Oral lichenoid lesions after thalidomide treatment [letter]: Dermatology. 1999;199(2):195. Unique Identifier : AIDSLINE MED/20025642; Bez C; Lodi G; Sardella A; Della Volpe A; Carrassi A
Methadone-maintained former heroin addicts, including those who are anti-HIV-1 seropositive, comply with and respond to hepatitis B vaccination.: Addiction. 1999 Apr;94(4):489-93. Unique Identifier : AIDSLINE MED/20073778; Borg L; Khuri E; Wells A; Melia D; Bergasa NV; Ho A; Kreek MJ; Rockefeller University, Laboratory on the Biology of Addictive; Diseases, New York, NY 10021, USA. borgl@rockvax.rockefeller.edu; AIMS: To study the efficacy of standard hepatitis B (HB) vaccination in methadone-maintained former intravenous drug users. DESIGN: HB vaccine was administered to subjects at 0, 1 and 6 months. SETTING: Two university-affiliated methadone maintenance clinics. PARTICIPANTS: Forty-three HB-unexposed former heroin addict
Serum soluble CD23 level correlates with subsequent development of AIDS-related non-Hodgkin's lymphoma.: Cancer Epidemiol Biomarkers Prev. 1999 Nov;8(11):979-84. Unique Identifier : AIDSLINE MED/20030828; Schroeder JR; Saah AJ; Hoover DR; Margolick JB; Ambinder RF; Martinez-Maza O; Breen EC; Jacobson LP; Variakojis D; Rowe DT; Armenian HK; Department of Epidemiology, Johns Hopkins University Baltimore,; Maryland 21205, USA.; The cytokine soluble CD23 (sCD23) has been shown to act as a B cell growth factor and to be elevated in serum prior to development of AIDS-related non-Hodgkin s lymphoma (AIDS NHL). To further characterize the elevation of serum sCD23 in AIDS NHL patients and investigate its potent
The solution structure of the anti-HIV chemokine vMIP-II.: Protein Sci. 1999 Nov;8(11):2270-80. Unique Identifier : AIDSLINE PDB/1VMP; Liwang AC; Wang ZX; Sun Y; Peiper SC; Liwang PJ; Texas A&M University, Department of Biochemistry and Biophysics,; College Station 77843-2128, USA.; We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which a
Real-time measurements of dark substrate catalysis.: Protein Sci. 1999 Nov;8(11):2460-4. Unique Identifier : AIDSLINE MED/20060999; Xie D; Suvorov L; Erickson JW; Gulnik AS; Structural Biochemistry Program, SAIC Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center,; Maryland 21702-1201, USA.; We have developed a novel procedure to monitor the real-time cleavage of natural unmodified peptides (dark substrates). In the competition-based assay, the initial cleavage rate of a fluorogenic peptide substrate is measured in the presence of a second substrate that is not required to exhibit any optical property cha
Monomer-trimer equilibrium of the ectodomain of SIV gp41: insight into the mechanism of peptide inhibition of HIV infection.: Unique Identifier : AIDSLINE MED/99421335; Caffrey M; Kaufman J; Stahl S; Wingfield P; Gronenborn AM; Clore GM; The monomer-trimer equilibrium of the ectodomain of SIV gp41 (residues 27-149, e-gp41) has been characterized by analytical ultracentrifugation, circular dichroism (CD), and NMR spectroscopy. Based on analytical ultracentrifugation experiments performed at different rotor speeds and protein concentrations, the equilib
A simple in vivo assay for increased protein solubility.: Protein Sci. 1999 Sep;8(9):1908-11. Unique Identifier : AIDSLINE MED/99421336; Maxwell KL; Mittermaier AK; Forman-Kay JD; Davidson AR; Department of Molecular and Medical Genetics, University of; Toronto, Ontario, Canada.; Low solubility is a major stumbling block in the detailed structural and functional characterization of many proteins and isolated protein domains. The production of some proteins in a soluble form may only be possible through alteration of their sequences by mutagenesis. The feasibility of this approach has been demo
Viruses, cancer and AIDS.: FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):227-32. Unique Identifier : AIDSLINE MED/20044576; Weiss RA; Windeyer Institute of Medical Sciences, Royal Free and University; College Medical School, 46 Cleveland Street, London, UK.; r.weiss@ucl.ac.uk; Patients with AIDS are at risk of lymphoma and Kaposi s sarcoma. These tumours are associated with the gamma herpesviruses, Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8), although a proportion of AIDS lymphomas lacks both viruses. EBV and HHV-8 are latent in the tumour cells, with genes that play a direct r
The neuropathogenesis of HIV-1 infection.: FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):233-41. Unique Identifier : AIDSLINE MED/20044577; Zink WE; Zheng J; Persidsky Y; Poluektova L; Gendelman HE; The Center for Neurovirology and Neurodegenerative Disorders, the; Departments of Pathology and Microbiology and Internal Medicine,; University of Nebraska Medical Center, Omaha, NE 68198-5215, USA.; HIV encephalitis is the common pathologic correlate of HIV- dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected m
Potential role of CCR5 polymorphism in the development of AIDS dementia complex.: FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):243-7. Unique Identifier : AIDSLINE MED/20044578; Boven LA; van der Bruggen T; Sweder van Asbeck B; Marx JJ; Nottet HS; Eijkman-Winkler Institute for Microbiology, Infectious Diseases; and Inflammation, section NeuroImmunology, AZU, room G04.614,; Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The; Netherlands. l.a.boven@lab.azu.nl; The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (DeltaCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emphasize the importance of
Expression of zeta molecules is decreased in NK cells from HIV-infected patients.: FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):249-57. Unique Identifier : AIDSLINE MED/20044579; Geertsma MF; Stevenhagen A; van Dam EM; Nibbering PH; Department Infectious Diseases, Leiden University Medical Center,; P. O. Box 9600, 2300 RC, Leiden, The Netherlands.; geertsma@stad.dsl.nl; Cytolysis by natural killer (NK) cells is impaired in HIV infection. We investigated whether the expression of zeta (zeta) molecules, essential elements of signalling initiated upon ligation of, e.g., CD16, is reduced and if so, whether this reduction could be involved in defective cytolysis. FACS analysis revealed si
Population biology of Streptococcus pneumoniae isolated from oropharyngeal carriage and invasive disease.: Microbiology. 1999 Nov;145 ( Pt 11):3283-93. Unique Identifier : AIDSLINE GENBANK/AF157826; Muller-Graf CD; Whatmore AM; King SJ; Trzcinski K; Pickerill AP; Doherty N; Paul J; Griffiths D; Crook D; Dowson CG; Department of Biological Sciences, University of Warwick,; Coventry, UK.; The population structure of Streptococcus pneumoniae in a sample of 134 carried antibiotic-susceptible isolates, and 53 resistant and susceptible invasive isolates, was examined using a DNA-based version of multilocus enzyme electrophoresis: multilocus restriction typing (MLRT). This involved RFLP analysis of PCR prod
Immune response following fresh arterial homograft replacement for aortoiliac graft infection.: Eur J Vasc Endovasc Surg. 1999 Nov;18(5):424-9. Unique Identifier : AIDSLINE MED/20079670; Mirelli M; Stella A; Faggioli GL; Scolari MP; Iannelli S; Freyrie A; Buscaroli A; De Santis L; Resta F; Bonomini V; D'Addato M; Department of Vascular Surgery, S. Orsola Hospital, Bologna,; Italy.; INTRODUCTION: this prospective study defines the immune response to fresh arterial homograft replacement for graft infection. MATERIALS AND METHODS: ten patients who underwent ABO-compatible homograft transplantation were studied for anti-HLA antibody production, and CD3-CD4-CD8-positive lymphocytes subset. Immunologi
Treatment of HIV-related neutropenia.: Am J Health Syst Pharm. 1999 Dec 15;56 Suppl 5:S17-20. Unique Identifier : AIDSLINE MED/20078543; Wong RJ; Amgen Inc., Thousand Oaks, CA 91320, USA.; Several studies documenting the association of bacteremia and severity of neutropenia in HIV-infected patients, as well as studies using the colony stimulating factors filgrastim or sargramostim to prevent and treat neutropenia in this patient population, are summarized. Three studies are described in which low absolu
Update on the treatment of neutropenia in HIV-infected patients: introduction.: Am J Health Syst Pharm. 1999 Dec 15;56 Suppl 5:S3-4. Unique Identifier : AIDSLINE MED/20078540; Piscitelli SC; Clinical Pharmacokinetics Laboratory, Warren G. Magnuson Clinical; Center, National Institutes of Health, Bethesda, MD 20892-1196,; USA.
Etiology of neutropenia in HIV-infected patients.: Am J Health Syst Pharm. 1999 Dec 15;56 Suppl 5:S5-8. Unique Identifier : AIDSLINE MED/20078541; Jaresko GS; School of Pharmacy, University of Southern California, Los; Angeles, USA.; The causes of neutropenia in HIV-infected patients are described, as is the association of absolute neutrophil count (ANC) and the risk of bacterial infections. In patients with HIV infection, neutropenia can result from the disease or related malignancies, drug therapies, or opportunistic infections. HIV can cause ne
Neutrophil deficiency and dysfunction in HIV-infected patients.: Am J Health Syst Pharm. 1999 Dec 15;56 Suppl 5:S9-16. Unique Identifier : AIDSLINE MED/20078542; Pitrak DL; Westside VA Medical Center, University of Illinois at Chicago; 60612, USA.; This paper describes abnormal neutrophil function in HIV-infected patients, as well as the in vitro effect of filgrastim (granulocyte colony stimulating factor) on neutrophil function in HIV infection. Research shows that HIV-infected patients have a variety of defects in neutrophil function, including abnormalities i
In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.: RNA. 1999 Dec;5(12):1605-14. Unique Identifier : AIDSLINE MED/20072287; Duconge F; Toulme JJ; Institut National de la Sante et de la Recherche Medicale U; 386, IFR Pathologies Infectieuses, Universite Victor Segalen,; Bordeaux, France.; We selected RNA aptamers specific for the trans-activation responsive (TAR) RNA, a stem-loop structure crucial for the transcription of the integrated genome of the human immunodeficiency virus. Most of the selected sequences could be folded as imperfect hairpins and displayed a 5 -GUCCCAGA-3 consensus motif constitu
MOC-31 aids in the differentiation between adenocarcinoma and reactive mesothelial cells.: Cancer. 1999 Dec 25;87(6):390-4. Unique Identifier : AIDSLINE MED/20069218; Morgan RL; De Young BR; McGaughy VR; Niemann TH; Department of Pathology, The Ohio State University and The Arthur; G. James Cancer Hospital and Research Institute, Columbus, Ohio; 43210, USA.; BACKGROUND: Evaluation of effusion specimens for the presence of adenocarcinoma often is complicated by the presence of reactive mesothelial cells that can mimic adenocarcinoma. Ancillary studies, in particular immunohistochemistry, can be helpful in making this distinction. MOC-31 is an antibody that recently was rep
Use of magnetic beads for tissue DNA extraction and IS6110 Mycobacterium tuberculosis PCR.: Mol Pathol. 1999 Jun;52(3):158-60. Unique Identifier : AIDSLINE MED/20087718; Caldarelli-Stefano R; Vago L; Bonetto S; Nebuloni M; Costanzi G; Pathology Unit, L. Sacco Hospital, Institute of Biomedical; Sciences, University of Milan, Italy.; Polymerase chain reaction (PCR) techniques are used increasingly for the diagnosis of Mycobacterium tuberculosis infection and can be used on the DNA obtained from both frozen and formalin fixed, paraffin wax embedded tissues. However, the extraction of DNA by means of the conventional phenol/chloroform method is time
A new sulfated beta-galactan from clams with anti-HIV activity.: Carbohydr Res. 1999 Sep 15;321(1-2):121-7. Unique Identifier : AIDSLINE MED/20078130; Amornrut C; Toida T; Imanari T; Woo ER; Park H; Linhardt R; Wu SJ; Kim YS; Faculty of Pharmaceutical Sciences, Chiba University, Japan.; A new polysaccharide composed of galactan sulfate with a beta-(1-->3)-glycosidic linkage has been isolated from the marine clam species Meretrix petechialis. The polysaccharide was homogeneous in its composition containing D-galactose. The glycosidic linkage was examined by 2D DQF-COSY and 2D NOESY spectroscopy. The c
Multinucleated giant cells.: Curr Opin Hematol. 2000 Jan;7(1):40-7. Unique Identifier : AIDSLINE MED/20074202; Anderson JM; Institute of Pathology, Case Western Reserve University,; Cleveland, Ohio 44106, USA.; Recent studies directed toward developing a better understanding of the molecular and cellular biology basis of monocyte-derived multinucleated giant cell formation, function, and biologic activity are presented. In addition, HIV-1-infected T-lymphocyte syncytia and the significance of adhesion molecule/ligand interac
Airway inflammation and remodeling in asthma.: Curr Opin Pulm Med. 2000 Jan;6(1):15-20. Unique Identifier : AIDSLINE MED/20074099; Fahy JV; Corry DB; Boushey HA; Department of Medicine and the Cardiovascular Research Institute,; University of California at San Francisco, 94143-0111, USA.; An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes se
Modulation of CD4 cell cytokine production by colon cancer-associated mucin.: Cancer Immunol Immunother. 1999 Dec;48(9):525-32. Unique Identifier : AIDSLINE MED/20069225; Kim JA; Dayton MA; Aldrich W; Triozzi PL; The Ohio State University Comprehensive Cancer Center and The; Arthur G. James Cancer Hospital and Research Institute, Columbus,; Ohio 43210, USA.; PURPOSE: Mucins have been implicated in tumor-associated immunosuppression. The possibility that colon cancer mucin (CCM) may modulate T-helper 1 (TH1) activity was evaluated by investigating its effect on the production of interleukin-2 ( IL-2 ) by CD4+ cells, a process
Primate herpesviral oncogenes.: Mol Cells. 1999 Aug 31;9(4):345-9. Unique Identifier : AIDSLINE MED/99443619; Damania B; Lee H; Jung JU; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, MA 01772-9102, USA.; Gammaherpesviruses are the most rapidly growing members of the herpesviridae family. Gamma herpesviruses share similarity in their genome organizations and in early and late lytic genes that are required for viral replication. A distinct characteristic of gamma herpesviruses is their ability to establish latent infect
Analysis of integration activity of human immunodeficiency virus type-1 integrase.: Mol Cells. 1999 Aug 31;9(4):446-51. Unique Identifier : AIDSLINE MED/99443634; Kim DJ; Oh YT; Lee SK; Shin CG; Department of Biotechnology, Chung-Ang University, Ansung, Korea.; The integration activity of human immunodeficiency virus type-1 (HIV-1) integrase was characterized in vitro by using pre-processed oligonucleotide substrates. The highest level of integration activity was found at pH 6.5 to 7.0, while the endonucleolytic activity was highest at pH 7.4 to 8.0. Although the endonucleol
Essentials of immune response: the macrophage approach: the antibody approach.: Cancer J Sci Am. 1999 Sep-Oct;5(5):312-3. Unique Identifier : AIDSLINE MED/99455593
Phenylarsine oxide increases intracellular calcium mobility and inhibits Ca(2+)-dependent ATPase activity in thymocytes.: Mol Genet Metab. 1999 Nov;68(3):363-70. Unique Identifier : AIDSLINE MED/20032112; Hmadcha A; Carballo M; Conde M; Marquez G; Monteseirin J; Martin-Nieto J; Bedoya FJ; Pintado E; Sobrino F; Facultad de Medicina, Universidad de Sevilla, Seville, 41009,; USA.; A rise in intracellular Ca(2+) levels has been implicated as a regulatory signal for the initiation of lymphocyte proliferation. In the present study the mechanism underlying the elevation of [Ca(2+)] induced by phenylarsine oxide [PAO] was investigated in thymocytes. This agent inhibits HIV-1 replication and also NF-
Comparison of the Murex Hybrid Capture CMV DNA (v2.0) assay and the pp65 CMV antigenemia test for the detection and quantitation of CMV in blood samples from immunocompromised patients.: J Clin Virol. 1999 Dec;14(3):153-65. Unique Identifier : AIDSLINE MED/20080515; Schirm J; Kooistra A; van Son WJ; van der Bij W; Verschuuren E; Sprenger HG; Limburg PC; The TH; Regional Public Health Laboratory, Groningen, The Netherlands.; schirmjslg@compuserve.com; BACKGROUND: Presently the semiquantitative pp65 cytomegalovirus ( CMV ) antigenemia test on white blood cells is often used for monitoring transplant patients for the appearance of active CMV infections. However, the need for i
Seroprevalence of human herpes virus 8 in different Eritrean population groups.: Unique Identifier : AIDSLINE MED/20080516; Enbom M; Tolfvenstam T; Ghebrekidan H; Ruden U; Grandien M; Wahren B; Linde A; Department of Virology, Swedish Institute for Infectious Disease; Control, Microbiology and Tumor Biology Center, Karolinska; Institute, Stockholm. malin_enbom@hotmail.com; BACKGROUND: Human herpesvirus 8 (HHV-8) is associated with Kaposi s sarcoma. In the US and Europe, HHV-8 is believed to be mainly sexually transmitted, but reports from some African countries suggest non-sexual transmission. OBJECTIVES: To find out more about HHV-8 seroprevalence and transmission in Eastern Africa. ST
Evidence for Fas counter attack in vivo from a study of colorectal cancer.: Oncol Rep. 2000 Jan-Feb;7(1):45-7. Unique Identifier : AIDSLINE MED/20070584; Arbuckle E; Langlois NE; Eremin O; Heys SD; Cross House Hospital, Kilmarnoch, Aberdeen, UK.; Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohi
Blue and breathless.: Hosp Med. 1999 Jul;60(7):530. Unique Identifier : AIDSLINE MED/20073483; Seaton RA; Nathwani D; Kirk J; France AJ; Infection and Immunodeficiency Unit, Kings Cross Hospital, Dundee; Teaching Hospitals NHS Trust.
Lack of association between acquisition of TT virus and risk behavior for HIV and HCV infection in Vietnam.: Int J Infect Dis. 1999 Summer;3(4):181-5. Unique Identifier : AIDSLINE MED/20045123; Nerurkar VR; Woodward CL; Nguyen HT; DeWolfe Miller F; Tashima LT; Zalles-Ganley A; Chua PK; Peterson JE; Chi PK; Hoang LT; Detels R; Yanagihara R; Retrovirology Research Laboratory, Pacific Biomedical Research; Center, University of Hawaii at Manoa, Honolulu, Hawaii 96816,; USA. nerurkar@hawaii.edu; BACKGROUND: The search for the cause of chronic hepatitis among individuals with non-A to G hepatitis has led to the discovery of a post-transfusion hepatitis-related DNA virus, designated TT virus (TTV), which, based on viral sequences, belongs to a new virus family. The principal modes of infection with TTV are poor
Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders.: Int J Infect Dis. 1999 Summer;3(4):186-91. Unique Identifier : AIDSLINE MED/20045124; Lu Y; Nerurkar VR; Dashwood WM; Woodward CL; Ablan S; Shikuma CM; Grandinetti A; Chang H; Nguyen HT; Wu Z; Yamamura Y; Boto WO; Merriwether A; Kurata T; Detels R; Yanagihara R; Retrovirology Research Laboratory, Hawaii AIDS Research; Consortium, and Native Hawaiian Health Research Program, Pacific; Biomedical Research Center, University of Hawaii at Manoa,; Honolulu, Hawaii 96816, USA. ylu@pbrc.hawaii.edu; BACKGROUND: A 32-base pair (bp) deletion mutation in the beta-chemokine receptor CCR5 gene has been associated with resistance against human immunodeficiency virus type 1 (HIV-1) infection and disease. Large-scale studies conducted among Caucasians indicate that individuals who are homozygous for this deletion mutatio
IS1245 genotypic analysis of Mycobacterium avium isolates from patients in Brazil.: Int J Infect Dis. 1999 Summer;3(4):192-6. Unique Identifier : AIDSLINE MED/20045125; Saad MH; Fonseca LD; Ferrazoli L; Fandinho F; Palaci M; Grinsztejn B; Kritski A; Werneck A; Poltoratskaia N; Johnson WD Jr; Riley LW; Fundacao Oswaldo Cruz, Lab. de Hanseniase, Rio de Janeiro,; Brazil.; OBJECTIVE: Disseminated Mycobacterium avium infection is an emerging opportunistic disease among patients with acquired immunodeficiency syndrome (AIDS) in Brazil . The mode of transmission of M. avium in a developing country setting needs to be better characterized. METHODS: Mycoba
Prevalence of intestinal parasitic infections in patients with acquired immunodeficiency syndrome in Brazil.: Int J Infect Dis. 1999 Summer;3(4):203-6. Unique Identifier : AIDSLINE MED/20045127; Cimerman S; Cimerman B; Lewi DS; Center for Immunological Deficiencies Control, Universidade; Federal do Estado de Sao Paulo; Instituto de Infectologia; Emilio Ribas. sc@mandic.com.br; OBJECTIVES: To evaluate the prevalence of intestinal parasitic infections and to investigate the possible associations of clinical status and laboratory findings with the different parasites found in stool samples. METHODS: Each patient was provided with one standard fecal collection vial containing 10% formalin for d
Nasopharyngeal carriage of multidrug-resistant Streptococcus pneumoniae in institutionalized HIV-infected and HIV-negative children in northeastern Romania.: Int J Infect Dis. 1999 Summer;3(4):211-5. Unique Identifier : AIDSLINE MED/20045129; Leibovitz E; Dragomir C; Sfartz S; Porat N; Yagupsky P; Jica S; Florescu L; Dagan R; Pediatric Infectious Disease Unit, Soroka University Medical; Center and Faculty of Health Sciences, Ben-Gurion University of; the Negev, Beer-Sheva, Israel. eugenel@bgumail.bgu.ac.il; OBJECTIVES: The study compared nasopharyngeal carriage of resistant pneumoniae in human immunodeficiency virus (HIV)-seropositive and -seronegative children. METHODS: Nasopharyngeal colonization with Streptococcus pneumoniae was investigated during May 1996 in 162 HIV-negative infants and children (age range, 1-38 mo)
Evaluation of the ZIG-ZAIDS game: a playful-educative resource for HIV/AIDS prevention.: Cad Saude Publica. 1999 Nov;15 Suppl 2:107-20. Unique Identifier : AIDSLINE MED/20047236; Schall VT; Monteiro S; Rebello SM; Torres M; Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Av.; Augusto de Lima 1715, Barro Preto, Belo Horizonte, MG 30190-002; Brasil. vtschall@cpqrr.fiocruz.br; This article presents the evaluation process for the ZIG-ZAIDS game, investigating the material s applicability in formal and informal educational contexts, i.e., how the game has been used by health professionals, parents, and the target population (pre-adolescents, or children over 9 years old). The study involved e
[Evaluation of counseling activities: analysis of a person-centered prevention perspective]: Cad Saude Publica. 1999 Nov;15 Suppl 2:121-32. Unique Identifier : AIDSLINE MED/20047237; Filgueiras SL; Deslandes SF; Coordenacao Nacional DST/Aids, Secretaria de Politicas de; Saude, Ministerio da Saude, Esplanada dos Ministerios,; Ministerio da Saude, bloco G, sobreloja, Brasilia DF; 70058-900, Brasil. filgueiras@aids.gov.br; This paper evaluates STD/HIV/AIDS counseling activities provided by the Brazilian National Health Care System (SUS). The following institutional health services were assessed: four anonymous testing and counseling centers, one clinic specializing in treatment for people with HIV, and five STD clinics. All the above ar
[Lessons from health education for HIV/AIDS prevention: theoretical elements for the construction of a new integrated practice]: Unique Identifier : AIDSLINE MED/20047234; Merchan-Hamman E; Departamento de Saude Coletiva, Faculdade de Ciencias da; Saude, Universidade de Brasilia, Campus Universitario Darcy; Ribeiro, Asa Norte, Brasilia, D.F., 70910-900, Brasil.; There is an evident contrast between health education practices and theoretical reflection concerning them as models. Health education practices have undergone considerable development in terms of strategies, methods, and modalities, while theoretical models have remained deficient, reductionist, fragmentary, and focu
General population and HIV prevention: from risk to action.: Cad Saude Publica. 1999 Nov;15 Suppl 2:93-106. Unique Identifier : AIDSLINE MED/20047235; Paicheler G; Centre de Recherche Medecine, Maladie et Sciences Sociales; (CERMES), Centre National de la Recherche Scientifique, CERMES,; 182, boulevard de la Villette, 75019, Paris, France.; Paichele@ext.jussieu.fr; Since knowledge about AIDS transmission now appears to be very good, many observers are surprised that more people do not practice behavior, like safer sex, designed to minimize risk of contracting the disease. Still, previous studies have not shown that there is a direct link between knowledge and behavior. New model
Screening of Korean plants against human immunodeficiency virus type 1 protease.: Phytother Res. 1999 Dec;13(8):680-2. Unique Identifier : AIDSLINE MED/20063561; Min BS; Bae KH; Kim YH; Miyashiro H; Hattori M; Shimotohno K; College of Pharmacy, Chungnam National University, Taejon; 305-764, Korea.; With the aim of finding novel anti-human immunodeficiency virus agents from natural products, 93 MeOH extracts of Korean plants were screened for their inhibitory activities against HIV-1 protease. The most potent inhibition was shown by the root of Rodiola rosea with 70.4% inhibition at a concentration of 100 microg/
Human herpesvirus-8 in lymphomatous and nonlymphomatous body cavity effusions developing in Kaposi's sarcoma and multicentric Castleman's disease.: Ann Diagn Pathol. 1999 Dec;3(6):357-63. Unique Identifier : AIDSLINE MED/20063572; Ascoli V; Sirianni MC; Mezzaroma I; Mastroianni CM; Vullo V; Andreoni M; Narciso P; Scalzo CC; Nardi F; Pistilli A; Lo Coco F; Dipartimento di Medicina Sperimentale e Patologia,; Università La Sapienza, Roma, Italy.; Human herpesvirus-8 (HHV-8) has been associated with Kaposi s sarcoma, multicentric Castleman s disease and primary effusion lymphoma. Kaposi s sarcoma and multicentric Castleman s disease patients may develop body cavity effusions that, unlike primary effusion lymphoma, are poorly characterized. To better define thes
Complications associated with the treatment of haemophiliacs with inhibitors.: Haemophilia. 1999 Sep;5 Suppl 3:11-7. Unique Identifier : AIDSLINE MED/20065251; Green D; Northwestern University, Hemophilia Program, Chicago, IL 60611,; USA.; To examine the safety profile of products used to treat inhibitor patients unresponsive to factor VIII, a review of published clinical experience was performed. The products evaluated were activated prothrombin complex concentrates (aPCCs), such as AUTOPLEX T, porcine factor VIII and recombinant activated factor VII (
Efficacy of viral clearance methods used in the manufacture of activated prothrombin complex concentrates: focus on AUTOPLEX T.: Haemophilia. 1999 Sep;5 Suppl 3:19-23. Unique Identifier : AIDSLINE MED/20065252; Horwith G; Revie DR; Nabi, Rockville, MD 20852, USA.; Various methods are described for the elimination of infectious viruses from activated prothrombin complex concentrates (aPCCs) and for the analysis of the final products (AUTOPLEX T and FEIBA VH). Viruses of concern in human plasma-derived products are enveloped (hepatitis B and C, cy
Non-AIDS-defining neoplasms and HIV infection.: Unique Identifier : AIDSLINE MED/20036963; Ventura G; Tacconelli E; Tumbarello M; Lucia MB; Larocca LM; Cauda R; The purpose of this study was to characterise the epidemiological and the clinical features of non-AIDS-defining neoplasms (NAN) in HIV-infected subjects in the era of highly active antiretroviral therapy (HAART). A retrospective cohort of 4,041 subjects was established. Patients were recruited from January 1989 to De
Characterisation of moisture uptake effects on the glass transitional behaviour of an amorphous drug using modulated temperature DSC.: Int J Pharm. 1999 Dec 1;192(1):39-46. Unique Identifier : AIDSLINE MED/20042507; Royall PG; Craig DQ; Doherty C; The School of Pharmacy, University of London, 29-39 Brunswick; Square, London, UK.; The purpose of this study was to investigate the depression of the glass transition temperature, T(g), of the protease inhibitor saquinavir in the first heating scan as a function of the quantity of sorbed water by the application of modulated temperature differential scanning calorimetry (MTDSC). Samples of amorphous
Cytokines in experimental colitis [editorial]: Clin Exp Immunol. 1999 Dec;118(3):337-9. Unique Identifier : AIDSLINE MED/20063705; Garside P
Highly active anti-retroviral therapy (HAART) is associated with a lower level of CD4+ T cell apoptosis in HIV-infected patients.: Clin Exp Immunol. 1999 Dec;118(3):412-6. Unique Identifier : AIDSLINE MED/20063717; Roger PM; Breittmayer JP; Arlotto C; Pugliese P; Pradier C; Bernard-Pomier G; Dellamonica P; Bernard A; Service des Maladies Infectieuses et Tropicales, INSERM U343,; Hopital de l'Archet, Nice, France.; HAART may increase CD4+ T cell counts despite a persistently detectable HIV load. The impact of HAART on apoptosis, which may play a role in the disease process in HIV-infected patients, has not been extensively studied. We performed a study to compare the level of spontaneous T cell apoptosis and anti-retroviral trea
Elevated levels of beta-chemokines in bronchoalveolar lavage fluid (BALF) of individuals infected with human T lymphotropic virus type-1 (HTLV-1).: Clin Exp Immunol. 1999 Dec;118(3):417-22. Unique Identifier : AIDSLINE MED/20063718; Seki M; Kadota JI; Higashiyama Y; Iida K; Iwashita T; Sasaki E; Maesaki S; Tomono K; Kohno S; Second Department of Internal Medicine, Nagasaki University; School of Medicine, Nagasaki, Japan.; Pulmonary complications are known to develop in HTLV-1 carriers, including T lymphocytic alveolitis, and increased IL-2 receptor alpha (CD25)-bearing T cells have been found in BALF. Several chemokines may contribute to accumulation of T lymphocytes in the lungs of HTL
Effects of cocaine administration to influenza virus-immunized mice on cytokine profiles of individual splenic CD4+ and CD8+ T cells.: Clin Exp Immunol. 1999 Dec;118(3):428-34. Unique Identifier : AIDSLINE MED/20063720; Di Francesco P; Falchetti R; Gaziano R; Lanzilli G; Casalinuovo IA; Ravagnan G; Garaci E; Department of Experimental Medicine and Biochemical Sciences,; University of Rome, Rome, Italy.; We have analysed the effects of cocaine, administered to mice during the in vivo differentiation of effector T cells stimulated by antigen (influenza virus) recognition, on the frequency of IL-2-, IL-4- and interferon-gamma (IFN-gamma)-expressing CD4+ and CD8+ T cells. Each animal was injected intraperitoneally with 1
Gammadelta T cells in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS).: Clin Exp Immunol. 1999 Dec;118(3):451-7. Unique Identifier : AIDSLINE MED/20063724; Freysdottir J; Lau S; Fortune F; Department of Oral Medicine, Leeds Dental Institute, Leeds, UK.; The immunopathogenesis of BD is believed to be T cell-mediated. The objective of this study was to characterize the activation stage and cytokine profile of peripheral blood lymphocytes (PBL), with particular emphasis on gammadelta T cells. Venous blood was collected from 20 patients with BD, and for comparison, from
The clinical spectrum of osteoarticular tuberculosis in non-human immunodeficiency virus patients in a defined area of northwestern Spain (1988-1997).: Clin Exp Rheumatol. 1999 Nov-Dec;17(6):663-9. Unique Identifier : AIDSLINE MED/20077064; Gonzalez-Gay MA; Garcia-Porrua C; Cereijo MJ; Rivas MJ; Ibanez D; Mayo J; Division of Rheumatology, Hospital Xeral-Calde, Lugo, Spain.; OBJECTIVE: To examine the frequency and clinical manifestations of osteoarticular tuberculosis in non-human immunodeficiency virus (HIV) patients during the past 10 years in a northwestern area of Spain . METHODS: The charts of all patients older than 14 years of age, not HIV-infecte
Increase in heterosexually acquired AIDS among Japanese, 1986 to 1996.: Jpn J Infect Dis. 1999 Aug;52(4):167-8. Unique Identifier : AIDSLINE MED/20060484; Umeda T; Division of International Cooperation, National Institute of; Infectious Diseases, Tokyo. umedat@nih.go.jp
Hepatitis A virus outbreak; a possible indicator of high risk sexual behavior among HIV-1 infected homosexual men.: Jpn J Infect Dis. 1999 Aug;52(4):173-4. Unique Identifier : AIDSLINE MED/20060488; Kojima T; Tachikawa N; Yosizawa S; Yasuoka C; Yamamoto Y; Genka I; Teruya K; Kikuchi Y; Aoki M; Yasuoka A; Oka S; AIDS Clinical Center, International Medical Center of Japan,; Tokyo.
Two possible pathways for acquisition of mutations related to nelfinavir resistance.: Jpn J Infect Dis. 1999 Aug;52(4):175-6. Unique Identifier : AIDSLINE MED/20060489; Sugiura W; Oishi T; Okano A; Matsuda M; Abumi H; Yamada K; Koike M; Taki M; Ishikawa M; Miura T; Fukutake K; Gouchi K; Ajisawa A; Iwamoto A; Hanabusa H; Mimaya J; Takamatsu J; Takata N; Kakishita E; Higasa S; Kashiwagi S; Shirahata A; Nagai Y; AIDS Research Center, National Institute of Infectious Diseases,; Tokyo. wsugiura@nih.go.jp
Paediatric AIDS incidence in Europe and the USA, 1985-96.: J Epidemiol Biostat. 1999;4(2):75-81. Unique Identifier : AIDSLINE MED/20085774; Dal Maso L; Parazzini F; Lo Re A; Favero A; La Vecchia C; Franceschi S; Servizio di Epidemiologia, Centro di Riferimento Oncologico,; Aviano, Italy.; BACKGROUND: AIDS has shown dramatic increases among women in the last decade; this has facilitated the spread of paediatric AIDS. Incidence rates of AIDS in children are essential for international comparisons at a population level. METHODS: Incidence rates of AIDS 1985-96 by 3-year period in children
Yale School of Nursing researchers help people with AIDS benefit from drug therapies by meeting them where they live.: Conn Nurs News. 1999 Mar-May;72(1):15. Unique Identifier : AIDSLINE MED/20081306; Shaddox C; External Affairs, Yale University School of Nursing, USA.
Management of idiopathic ulcer of the anal canal by excision in HIV-positive patients.: Dis Colon Rectum. 1999 Dec;42(12):1598-601. Unique Identifier : AIDSLINE MED/20078641; Nadal SR; Manzione CR; Horta SH; Galvao V; Department of Proctology, The Emilio Ribas Infectious Diseases; Institute, Sao Paulo, Brazil.; PURPOSE: The aim of this article is to show our results from the surgical treatment of idiopathic anal ulcers. METHODS: We present 33 patients with acquired immunodeficiency syndrome and idiopathic perianal ulcers. They presented with anal pain that failed to improve with medical treatment. Evaluation under anesthesia
Pneumocystis carinii infection presents as common bile duct mass biopsied by fine-needle aspiration.: Diagn Cytopathol. 2000 Jan;22(1):25-6. Unique Identifier : AIDSLINE MED/20082824; Yang GC; Department of Pathology, New York University Medical Center, New; York, New York, USA. grace.yang@nyu.edu; This paper describes a case of Pneumocystis carinii (PC) presenting as a common bile duct intraluminal mass in an HIV-infected 30-yr-old homosexual man. In fine-needle aspiration smears, exuberant vascular proliferation associated with multinucleated giant-cell reactions was found within the granular exudate of PC. Co
Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men.: Eur Respir J. 1999 Nov;14(5):1231-4. Unique Identifier : AIDSLINE MED/20061831; Ascoli V; Scalzo CC; Danese C; Vacca K; Pistilli A; Lo Coco F; Anatomia Patologica, Dipartimento di Medicina Sperimentale e; Patologia, Universita La Sapienza Roma, Italy.; Human herpes virus-8 (HHV-8)-associated primary effusion lymphoma (PEL) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (HIV)-positive men at high risk for Kaposi s sarcoma (KS). We describe two HIV-negative elderly Italian men, who developed pleural HHV-8-pos
Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB.: FEBS Lett. 1999 Nov 26;462(1-2):140-4. Unique Identifier : AIDSLINE MED/20047842; Kumar A; Dhawan S; Mukhopadhyay A; Aggarwal BB; Cytokine Research Section, Department of Molecular Oncology,; University of Texas M.D. Anderson Cancer Center, 1515 Holcombe; St. Box 143, Houston, TX 77030, USA.; We have previously shown that human immunodeficiency virus (HIV)-1-tat induces the production of matrix metalloproteinase-9 (MMP-9) in human monocytes by a mechanism that is not understood. In the present report, we demonstrate that HIV-tat-induced expression of MMP-9 is blocked by inhibitors of protein tyrosine phosp
Serial analysis of gene expression in HIV-1-infected T cell lines.: FEBS Lett. 1999 Nov 26;462(1-2):182-6. Unique Identifier : AIDSLINE MED/20047851; Ryo A; Suzuki Y; Ichiyama K; Wakatsuki T; Kondoh N; Hada A; Yamamoto M; Yamamoto N; Departments of Microbiology and Molecular Virology, School of; Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima,; Bunkyo-ku, Tokyo, Japan.; The gene expression profile of the HIV-1 infection state was analyzed in the human T cell line MOLT-4. Using the serial analysis of gene expression (SAGE) method, a total of 142{ omitted}603 SAGE tags were sequenced and identified, representing 43{ omitted}581 unique mRNA species. Comparison of expression patterns rev
HIV/AIDS & ageism.: Fla Nurse. 1998 Sep;46(7):14. Unique Identifier : AIDSLINE MED/20081385; Windey M; Florida Gulf Coast University, USA.
The art of nursing.: Fla Nurse. 1998 Sep;46(7):22. Unique Identifier : AIDSLINE MED/20081389; Gracia-Jones S
[Clinical and epidemiological characteristics of severe poisoning in an adult population admitted to an intensive care unit]: Gac Med Mex. 1999 Nov-Dec;135(6):669-75. Unique Identifier : AIDSLINE MED/20073198; Juarez-Aragon G; Castanon-Gonzalez JA; Perez-Morales AJ; Montoya Cabrera MA; OBJECTIVE: To describe the clinical and epidemiological features of severe acute poisonings in an adult population. DESIGN: Retrospective analysis of clinical cases. PATIENTS AND METHODS: Analysis of the clinical charts, risk factors and main outcomes of 55 acute poisoned patients admitted to an intensive care unit (I
Molecular analyses of the possible RNA-binding protein gene located in the human leukocyte antigen (HLA)--DR subregion.: Gene. 1999 Nov 15;240(1):125-32. Unique Identifier : AIDSLINE MED/20033555; Chida S; Hohjoh H; Tokunaga K; Department of Human Genetics, Graduate School of Medicine,; University of Tokyo, Tokyo, Japan.; We have previously found the sequence having potential for encoding a new protein in the human leukocyte antigen (HLA) class II region. The predicted amino acid sequence showed a significant sequence homology to the Xenopus double-stranded RNA-binding protein (Xlrbp) and the human cellular protein bound to the transac
Hepatitis G virus infection markers (RNA and anti-E2 antibodies) in a multicenter cohort of hemophiliacs.: Haematologica. 1999 Oct;84(10):930-6. Unique Identifier : AIDSLINE MED/99439741; Tassies D; Magallon M; Quintana M; Fernandez-Urgelles RP; Rodriguez-Pinto C; Tusell J; Altisent C; Reverter JC; Mazzara R; Ordinas A; Monteagudo J; Service of Hemotherapy and Hemostasis, Hospital Clinic; Villarroel 170, 08036 Barcelona, Spain. dtassies@medicina.ub.es; BACKGROUND AND OBJECTIVE: To investigate the prevalence and evolution of hepatitis G virus (HGV) infection in hemophiliacs and to correlate evolution of HGV infection markers with immunologic parameters in those patients co-infected with HIV. DESIGN AND METHODS: HGV RNA and anti-E2 antibodies were studied in 124 patie
A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice.: Hepatology. 2000 Jan;31(1):173-81. Unique Identifier : AIDSLINE MED/20080866; Brown JJ; Parashar B; Moshage H; Tanaka KE; Engelhardt D; Rabbani E; Roy-Chowdhury N; Roy-Chowdhury J; Departments of Medicine, Molecular Genetics, Marion Bessin Liver; Research Center, Groningen, The Netherlands.; Development of new therapies for human hepatitis B virus infection (HBV) would be greatly facilitated by the availability of a suitable small-animal model for HBV virus production in vivo. To develop a murine model for HBV production, we established an immortalized, cloned liver cell line by transferring the Simian Vi
Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B.: Hepatology. 2000 Jan;31(1):207-10. Unique Identifier : AIDSLINE MED/20080870; Villeneuve JP; Condreay LD; Willems B; Pomier-Layrargues G; Fenyves D; Bilodeau M; Leduc R; Peltekian K; Wong F; Margulies M; Heathcote EJ; Division of Hepatology, Centre Hospitalier de l'Universite de; Montreal, Montreal, Canada. villej@sympatico.ca; The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are outweighed by serious side effects and by the risk of fatal exacerbation of disease activity. Lamivudine rapidly red
Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study.: Hepatology. 2000 Jan;31(1):225-9. Unique Identifier : AIDSLINE MED/20080873; Fanning L; Kenny-Walsh E; Levis J; Choudhury KR; Cannon B; Sheehan M; Whelton M; Shanahan F; Hepatitis C Unit, Department of Medicine, Cork, University; College Cork, Cork, Ireland. l.fanning@ucc.ie; The aim of this study was to determine the variation in hepatitis C viral load over an extended period of patient follow up. Serum samples were collected from 49 female individuals who were identified as having been infected from the same source of hepatitis C-contaminated anti-D immunoglobulin during the period from
T-cell-dependent control of acute Giardia lamblia infections in mice.: Infect Immun. 2000 Jan;68(1):170-5. Unique Identifier : AIDSLINE MED/20072681; Singer SM; Nash TE; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892-0425, USA. sms3@gunet.georgetown.edu; We have studied immune mechanisms responsible for control of acute Giardia lamblia and Giardia muris infections in adult mice. Association of chronic G. lamblia infection with hypogammaglobulinemia and experimental infections of mice with G. muris have led to the hypothesis that antibodies are required to control thes
Involvement of CD4(+) Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi.: Infect Immun. 2000 Jan;68(1):197-204. Unique Identifier : AIDSLINE MED/20072685; Hoft DF; Schnapp AR; Eickhoff CS; Roodman ST; Departments of Internal Medicine, Saint Louis University Health; Sciences Center, St. Louis, Missouri 63110, USA. hoftdf@slu.edu; In general, gamma interferon (IFN-gamma)-producing CD4(+) Th1 cells are important for the immunological control of intracellular pathogens. We previously demonstrated an association between parasite-specific induction of IFN-gamma responses and resistance to the intracellular protozoan Trypanosoma cruzi. To investigat
Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.: Infect Immun. 2000 Jan;68(1):247-56. Unique Identifier : AIDSLINE MED/20072692; Osicka R; Osickova A; Basar T; Guermonprez P; Rojas M; Leclerc C; Sebo P; Cellular and Molecular Microbiology Division, Institute of; Microbiology of the Academy of Sciences of the Czech Republic,; CZ-142 20 Prague 4, Czech Republic.; Bordetella pertussis adenylate cyclase (AC) toxin-hemolysin (ACT-Hly) can penetrate a variety of eukaryotic cells. Recombinant AC toxoids have therefore been recently used for delivery of CD8(+) T-cell epitopes into antigen-presenting cells in vivo and for induction of protective antiviral, as well as therapeutic anti
Depletion of CD8(+) T cells in vivo impairs host defense of mice resistant and susceptible to pulmonary paracoccidioidomycosis.: Unique Identifier : AIDSLINE MED/20072705; Cano LE; Singer-Vermes LM; Costa TA; Mengel JO; Xidieh CF; Arruda C; Andre DC; Vaz CA; Burger E; Calich VL; Using a pulmonary model of infection, we demonstrated previously that A/Sn and B10.A mice are, respectively, resistant and susceptible to Paracoccidioides brasiliensis infection. Employing the same experimental model, we examined herein the role of CD8(+) T cells in the course of paracoccidioidomycosis. Treatment with
Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens.: Infect Immun. 2000 Jan;68(1):46-53. Unique Identifier : AIDSLINE MED/20072664; Mastroeni P; Simmons C; Fowler R; Hormaeche CE; Dougan G; Centre for Veterinary Science, University of Cambridge, Cambridge; CB3 OES, United Kingdom. pm274@cam.ac.uk; In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background (Igh-6(-/-)). Igh-6(-/-) mice immunized with a live, attenuated aroA Salmonella enterica serovar Typhimurium vaccine strain showed
Potential gains in life expectancy or years of potential life lost: impact of competing risks of death.: Int J Epidemiol. 1999 Oct;28(5):894-8. Unique Identifier : AIDSLINE MED/20064858; Lai D; Hardy RJ; School of Public Health, University of Texas, Houston 77030, USA.; BACKGROUND: Measuring the impact of competing risks of death on society is important for setting public health policy and allocating resources. However, various indicators may result in inconsistent conclusions. The potential gains in life expectancy (PGLE) by elimination of deaths from HIV/AIDS, diseases of the heart
The impact of the major causes of death on life expectancy in Italy.: Int J Epidemiol. 1999 Oct;28(5):905-10. Unique Identifier : AIDSLINE MED/20064860; Conti S; Farchi G; Masocco M; Toccaceli V; Vichi M; Laboratory of Epidemiology and Biostatistics, Istituto Superiore; di Sanita, Roma, Italy. susanna@iss.it; BACKGROUND: This study aims to evaluate the contribution of the reduction in major cardiovascular diseases (CVD), malignant neoplasms (MN), accidents and AIDS mortality to the gains in life expectancy observed during the decade 1985-1994, as well as to calculate and compare the potential gains due to the partial or to
The spectrum of AIDS-defining diseases: temporal trends in Italy prior to the use of highly active anti-retroviral therapies, 1982-1996.: Int J Epidemiol. 1999 Oct;28(5):975-81. Unique Identifier : AIDSLINE MED/20064869; Pezzotti P; Serraino D; Rezza G; Dal Maso L; Vaccher E; Lepri AC; Franceschi S; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome,; Italy. patrizio.pezzotti@iss.it; OBJECTIVE: To evaluate time trends of the spectrum of AIDS-defining diseases in Italy , 1982-1996. METHODS: Surveillance data from the Italian National AIDS Registry were used to assess temporal patterns of all AIDS-defining diseases diagnosed among adults as of December 1996. Twenty
[HIV infections and sexually transmitted diseases in travelers]: Internist (Berl). 1999 Nov;40(11):1168-73. Unique Identifier : AIDSLINE MED/20026213; Gurtler L; Institut fur Medizinische Mikrobiologie der Ernst Moritz Arndt; Universit]at Greifswald.
FTC targets HIV home kits from Internet [news]: J Ark Med Soc. 1999 Aug;96(3):84. Unique Identifier : AIDSLINE MED/99412648
Modifying human thymidylate kinase to potentiate azidothymidine activation.: J Biol Chem. 1999 Dec 10;274(50):35289-92. Unique Identifier : AIDSLINE MED/20054392; Brundiers R; Lavie A; Veit T; Reinstein J; Schlichting I; Ostermann N; Goody RS; Konrad M; Department of Molecular Genetics, Max Planck Institute for; Biophysical Chemistry, D-37070 Gottingen, Germany.; Based on the knowledge of the crystal structures of yeast and Escherichia coli thymidylate kinases (TmpKs) and the observation that TmpK from E. coli can phosphorylate azidothymidine monophosphate (AZT-MP) much more efficiently than either the yeast or the highly homologous human enzyme, we have engineered yeast and h
How an inhibitor of the HIV-I protease modulates proteasome activity.: J Biol Chem. 1999 Dec 10;274(50):35734-40. Unique Identifier : AIDSLINE MED/20054456; Schmidtke G; Holzhutter HG; Bogyo M; Kairies N; Groll M; de Giuli R; Emch S; Groettrup M; Research Department, Cantonal Hospital St. Gall, CH-9007 St.; Gallen, Switzerland.; The human immunodeficiency virus, type I protease inhibitor Ritonavir has been used successfully in AIDS therapy for 4 years. Clinical observations suggested that Ritonavir may exert a direct effect on the immune system unrelated to inhibition of the
The motif D loop of human immunodeficiency virus type 1 reverse transcriptase is critical for nucleoside 5'-triphosphate selectivity.: J Biol Chem. 1999 Dec 10;274(50):35768-76. Unique Identifier : AIDSLINE MED/20054461; Canard B; Chowdhury K; Sarfati R; Doublie S; Richardson CC; Centre National de la Recherche Scientifique, Ecole Superieure; d'Ingenieurs de Luminy, Architecture et Fonction des; Macromolecules Biologiques, 163 avenue de Luminy, 13288; Marseille cedex 9, France.; Human immunodeficiency virus type 1 reverse transcriptase (RT) has limited homology with DNA and RNA polymerases. The conserved Lys-220 of motif D is a signature of RNA-dependent polymerases. Motif D is located in the palm domain and forms a small loop from Thr-215 to Lys-223. This loop is absent from the polymerase
The E249K mutator mutant of DNA polymerase beta extends mispaired termini.: J Biol Chem. 1999 Dec 10;274(50):35866-72. Unique Identifier : AIDSLINE MED/20054473; Kosa JL; Sweasy JB; Yale University School of Medicine, Department of Therapeutic; Radiology, New Haven, Connecticut 06520, USA.; The DNA polymerase beta mutant enzyme, which is altered from glutamic acid to lysine at position 249, exhibits a mutator phenotype in primer extension assays and in the herpes simplex virus-thymidine kinase (HSV-tk) forward mutation assay. The basis for this loss of accuracy was investigated by measurement of misincor
The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes.: Unique Identifier : AIDSLINE PDB/1I1F; Kirksey TJ; Pogue-Caley RR; Frelinger JA; Collins EJ; Department of Microbiology, the University of North Carolina,; Chapel Hill, North Carolina 27599, USA.; Designing altered peptide ligands to generate specific immunological reactivity when bound to class I major histocompatibility complexes is important for both therapeutic and prophylactic reasons. We have previously shown that two altered peptides, derived from human immunodeficiency virus (HIV)-reverse transcriptase
Structure based prediction of binding affinity of human immunodeficiency virus-1 protease inhibitors.: J Chem Inf Comput Sci. 1999 Nov-Dec;39(6):1128-40. Unique Identifier : AIDSLINE MED/20081094; Kulkarni SS; Kulkarni VM; Department of Chemical Technology, University of Mumbai, Matunga,; India.; A series of computations were performed to derive a strategy for the prediction of binding affinities of non-peptidic human immunodeficiency virus-1 (HIV-1) protease inhibitors . This paper describes the development of a 3D quantitative structure-activity relationshi
Comparison of two molecular techniques for the detection of avian reoviruses in formalin-fixed, paraffin-embedded chicken tissues.: J Virol Methods. 1999 Jul;80(2):197-201. Unique Identifier : AIDSLINE MED/99397630; Liu HJ; Liao MH; Chang CD; Chen JH; Lin MY; Tung MC; Department of Veterinary Medicine, National Pingtung University; of Science and Technology, Taiwan, ROC. hjliu@mail.npust.edu.tw; Reverse transcription (RT) in situ polymerase chain reaction (PCR) and in situ hybridization (ISH) techniques were used to detect the sigma c-encoded gene of avian reovirus (ARV) in chicken tissue sections. The advantage of using in situ methods is to make more rapid and accurate diagnosis of ARV infections. The sensi
Reaction times are faster in HIV-seropositive patients on antiretroviral therapy: A preliminary report.: J Clin Exp Neuropsychol. 1999 Oct;21(5):730-5. Unique Identifier : AIDSLINE MED/20042377; Martin EM; Pitrak DL; Novak RM; Pursell KJ; Mullane KM; Departments of Psychiatry and Neurology, University of Illinois,; Chicago, IL, USA. emartin@psych.uic.edu; We evaluated subclinical mental and motor slowing in 142 HIV-seropositive patients without dementia , using computerized simple and choice reaction time tasks and self-report measures of psychological distress. Patients on antiretroviral therapy at the time of testing (n = 79) had s
Species and genotypic diversities and similarities of pathogenic yeasts colonizing women.: J Clin Microbiol. 1999 Dec;37(12):3835-43. Unique Identifier : AIDSLINE MED/20033614; Xu J; Boyd CM; Livingston E; Meyer W; Madden JF; Mitchell TG; Department of Microbiology, Department of Pathology, Duke; University Medical Center, Durham, North Carolina 27710, USA.; jpxu@acpub.duke.edu; We examined the patterns of strain relatedness among pathogenic yeasts from within and among groups of women to determine whether there were significant associations between genotype and host condition or body site. A total of 80 yeast strains were isolated, identified, and genotyped from 49 female volunteers, who wer
Bacteriological and molecular analysis of rifampin-resistant Mycobacterium tuberculosis strains isolated in Australia.: J Clin Microbiol. 1999 Dec;37(12):3844-50. Unique Identifier : AIDSLINE MED/20033615; Yuen LK; Leslie D; Coloe PJ; Victorian Infectious Diseases Reference Laboratory, North; Melbourne, 3051, Australia. lily.yuen@nwhcn.org.au; To develop a better understanding of the epidemiology and molecular biology of rifampin-resistant Mycobacterium tuberculosis strains in Australia , 50 clinical isolates (33 rifampin-resistant and 17 rifampin-sensitive strains) cultured between 1990 and 1997 were analyzed by a num
Evolution and clonal traits of Mycobacterium tuberculosis complex in Guinea-Bissau.: J Clin Microbiol. 1999 Dec;37(12):3872-8. Unique Identifier : AIDSLINE MED/20033620; Kallenius G; Koivula T; Ghebremichael S; Hoffner SE; Norberg R; Svensson E; Dias F; Marklund BI; Svenson SB; Department of Bacteriology, Swedish Institute for Infectious; Disease Control, S-17182 Solna, Sweden.; gunilla.kallenius@smi.ki.se; Two hundred twenty-nine consecutive isolates of Mycobacterium tuberculosis complex from patients with pulmonary tuberculosis in Guinea-Bissau , which is located in West Africa, were analyzed for clonal origin by biochemical typing and DNA fingerprinting. By using four biochemical t
Disseminated infection with Mycobacterium genavense: a challenge to physicians and mycobacteriologists.: J Clin Microbiol. 1999 Dec;37(12):3901-5. Unique Identifier : AIDSLINE MED/20033625; Thomsen VO; Dragsted UB; Bauer J; Fuursted K; Lundgren J; Department of Mycobacteriology, Statens Serum Institut,; Copenhagen, Denmark. vot@ssi.dk; In the present study we compared the clinical presentations of patients with a clinical diagnosis of AIDS and disseminated Mycobacterium genavense infection (n = 12) with those of patients with AIDS and disseminated M. avium complex (MAC) infection (n = 24). Abdominal pain was seen more frequently in the group of pati
Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively.: J Clin Microbiol. 1999 Dec;37(12):3940-5. Unique Identifier : AIDSLINE MED/20033632; De Jong JC; Wermenbol AG; Verweij-Uijterwaal MW; Slaterus KW; Wertheim-Van Dillen P; Van Doornum GJ; Khoo SH; Hierholzer JC; Research Laboratory of Infectious Diseases, National Institute of; Public Health and the Environment (RIVM), 3720 BA Bilthoven.; jc.de.jong@wxs.nl; Adenovirus (Ad) isolates from a large number of human immunodeficiency virus (HIV)-infected individuals were compared serologically and genetically with Ad isolates from immunocompetent patients. Between 1982 and 1994, stool and urine samples from 137 subjects with AIDS hospitalized in The
Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis.: J Clin Microbiol. 1999 Dec;37(12):4034-8. Unique Identifier : AIDSLINE MED/20033647; Kerkhoff FT; Bergmans AM; van Der Zee A; Rothova A; Department of Ophthalmology, F. C. Donders Institute, University; Hospital, Utrecht, The Netherlands. fkerkh@oogheel.azu.nl; We describe the clinical and laboratory features of a 55-year-old human immunodeficiency virus-negative female patient who presented with bilateral intraocular inflammatory disease (neuroretinitis type) and behavioral changes caused by a Bartonella grahamii infection. Diagnosis was based on the PCR analysis of DNA ext
Identification of Bartonella species directly in clinical specimens by PCR-restriction fragment length polymorphism analysis of a 16S rRNA gene fragment.: J Clin Microbiol. 1999 Dec;37(12):4045-7. Unique Identifier : AIDSLINE MED/20033650; Matar GM; Koehler JE; Malcolm G; Lambert-Fair MA; Tappero J; Hunter SB; Swaminathan B; Department of Microbiology and Immunology, American University of; Beirut, Beirut, Lebanon. gmatar@aub.edu.lb; It is now established that two species of Bartonella, namely, Bartonella henselae and B. quintana, cause bacillary angiomatosis in human immunodeficiency virus-infected patients. In addition, B. henselae causes cat scratch disease and B. quintana, B. henselae, and B. elizabet
Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: survey of 787 sequences.: J Clin Microbiol. 1999 Dec;37(12):4099-106. Unique Identifier : AIDSLINE MED/20033659; Yahi N; Tamalet C; Tourres C; Tivoli N; Ariasi F; Volot F; Gastaut JA; Gallais H; Moreau J; Fantini J; Laboratoire de Virologie, UF SIDA, CHRU de la Timone, 13005; Marseille, France.; The aim of the present study was to evaluate the resistance-associated mutations in 302 human immunodeficiency virus type 1 (HIV-1)-infected patients receiving combination therapy and monitored in Marseille, France , hospitals from J
Production of monoclonal antibodies directed against the microsporidium Enterocytozoon bieneusi.: J Clin Microbiol. 1999 Dec;37(12):4107-12. Unique Identifier : AIDSLINE MED/20033660; Accoceberry I; Thellier M; Desportes-Livage I; Achbarou A; Biligui S; Danis M; Datry A; Unite INSERM 511, Laboratoire de Parasitologie-Mycologie, Centre; Hospitalier-Universitaire de la Pitie-Salpetriere, 75013; Paris, France.; Several hybridomas producing antibodies detected by indirect immunofluorescence antibody test (IFAT) were established by fusion of mouse myeloma SP2/O with spleen cells from BALB/c mice immunized against whole spores (protocol 1) or chitinase-treated spores (protocol 2) of Enterocytozoon bieneusi and were cloned twice
Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.: J Clin Invest. 1999 Dec;104(12):1715-22. Unique Identifier : AIDSLINE MED/20075041; Trambley J; Bingaman AW; Lin A; Elwood ET; Waitze SY; Ha J; Durham MM; Corbascio M; Cowan SR; Pearson TC; Larsen CP; The Carlos and Marguerite Mason Transplantation Research Center,; Department of Surgery, Emory University School of Medicine,; Atlanta, Georgia 30322, USA.; Simultaneous blockade of the CD40 and CD28 costimulatory pathways is an effective treatment strategy to promote allograft acceptance but does not lead to indefinite allograft survival. The immune mechanisms responsible for costimulation-independent rejection are not defined. Here we have studied the rejection response
Bone marrow CD34(+) cells and megakaryoblasts secrete beta-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV.: J Clin Invest. 1999 Dec;104(12):1739-49. Unique Identifier : AIDSLINE MED/20075044; Majka M; Rozmyslowicz T; Lee B; Murphy SL; Pietrzkowski Z; Gaulton GN; Silberstein L; Ratajczak MZ; Department of Medicine, Hematology/Oncology Division, University; of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; 19104, USA.; CD34(+) cells are nonpermissive to infection by HIV strains X4 and R5, despite the fact that many CD34(+) cells express high levels of the viral receptor protein CD4 and the coreceptor CXCR4 on their surface. In these cells, the co-receptor CCR5 protein, which, like CXCR4, is a chemokine receptor, is detected mainly i
Third World debt puts AIDS drugs beyond reach [news]: J Adv Nurs. 1999 Dec;30(6):1250. Unique Identifier : AIDSLINE MED/20091972
A comparison of three strategies for risk-adjustment of outcomes for AIDS patients hospitalized for Pneumocystis carinii pneumonia.: J Adv Nurs. 1999 Dec;30(6):1424-31. Unique Identifier : AIDSLINE MED/20050765; Bakken S; Dolter KJ; Holzemer WL; Department of Community Health Systems, School of Nursing,; University of California, San Francisco, USA.; Suh7001@flux.cpmc.columbia.edu; BACKGROUND: The need for risk-adjustment of patient outcomes has been driven by the competitive health care market and the subsequent increase in comparative outcome reporting among health care institutions, among managed care plans, and among individual providers for some procedures (e.g. coronary artery bypass graft
Atopy: immunodeviation and environment[editorial]: J Allergy Clin Immunol. 1999 Dec;104(6):1128-30. Unique Identifier : AIDSLINE MED/20057798; Brehler R; Luger TA; Von-Esmarch-Str 56, D-148149 Munste.
Immunostimulatory oligodeoxynucleotide induces TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice.: J Allergy Clin Immunol. 1999 Dec;104(6):1231-8. Unique Identifier : AIDSLINE MED/20057813; Kohama Y; Akizuki O; Hagihara K; Yamada E; Yamamoto H; Department of Immunology, The Graduate School of Pharmaceutical; Sciences, Osaka University, Osaka, Japan.; BACKGROUND: Immunotherapy for cedar pollinosis makes use of multiple injections of allergens, but its effectiveness remains controversial. Recent studies indicate that immunization with certain protein antigens and immunostimulatory DNA sequence (ISS) oligodeoxynucleotides (ODNs) represent a potential approach to alle
CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma.: J Allergy Clin Immunol. 1999 Dec;104(6):1258-64. Unique Identifier : AIDSLINE MED/20057817; Kline JN; Krieg AM; Waldschmidt TJ; Ballas ZK; Jain V; Businga TR; Departments of Medicine and Pathology, University of Iowa College; of Medicine, Iowa City, USA.; BACKGROUND: Oligodeoxynucleotides (ODNs) containing the dinucleotide CpG in a specific sequence context (CpG-ODNs) have the ability to prevent the development of eosinophilic airway inflammation and bronchial hyperreactivity in a murine model of asthma. We have previously demonstrated that CpG-ODNs stimulate expressio
Obesity and immune function in the Miami HIV-1 infected drug abusers study [letter]: J Am Diet Assoc. 1999 Dec;99(12):1512. Unique Identifier : AIDSLINE MED/20076942; Shor-Posner G; Campa A; Zhang G; Persaud N; Baum MK
Combined antiviral therapy reduces HIV-1 plasma load and improves CD4 counts but does not interfere with ongoing lymphocyte apoptosis.: Immunopharmacol Immunotoxicol. 1999 Nov;21(4):645-65. Unique Identifier : AIDSLINE MED/20051591; Moretti S; Alesse E; Marcellini S; Di Marzio L; Zazzeroni F; Parroni R; Famularo G; Boschini A; Cifone MG; De Simone C; Department of Experimental Medicine, University of L'Aquila,; Italy.; The progression of HIV-1 disease appears associated with an unregulated Fas-mediated apoptosis of lymphocytes that involves the activation of ICE protease and ceramide generation and antiviral therapy may not be fully effective in the absence of a relevant impact on apoptosis. Six drug-naive HIV-1-infected symptomless
Helicobacter pylori infection and host cell responses.: Immunopharmacol Immunotoxicol. 1999 Nov;21(4):803-46. Unique Identifier : AIDSLINE MED/20051602; Di Leo A; Messa C; Russo F; Linsalata M; Amati L; Caradonna L; Pece S; Pellegrino NM; Caccavo D; Antonaci S; Jirillo E; Laboratory of Biochemistry, IRCCS Saverio de Bellis, Castellana; Grotte, Bari, Italy.; It is well known that Helicobacter pylori is able to colonize the gastric mucosa, causing a chronic and persistent infection with complications, such as peptic ulcer and gastric cancer. This review places emphasis on some epidemiological aspects of Helicobacter pylori infection and its mode of transmission. At the sam
Use of herpesvirus saimiri-immortalized macaque CD4(+) T cell clones as stimulators and targets for assessment of CTL responses in macaque/AIDS models.: J Immunol Methods. 1999 Nov 19;230(1-2):47-58. Unique Identifier : AIDSLINE MED/20062942; Kumar A; Stipp HL; Sheffer D; Narayan O; Marion Merrell Dow Laboratory of Viral Pathogenesis and; Department of Microbiology, Molecular Genetics and Immunology,; University Kansas Medical Center, Kansas City, KS 66160, USA.; akumar@kumc.edu; Herpesvirus saimiri (HVS), a nonhuman primate gamma herpes virus, was used to immortalize pig-tailed macaque CD4(+) T lymphocytes. The HVS-immortalized T cell lines were used to develop CD4(+) T cell clones from two animals. Three CD4(+) T cell clones were further characterized for the expression of cell surface marke
A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens.: J Immunol Methods. 1999 Nov 19;230(1-2):99-112. Unique Identifier : AIDSLINE MED/20062946; Givan AL; Fisher JL; Waugh M; Ernstoff MS; Wallace PK; Department of Physiology, Dartmouth Medical School, Lebanon, NH; 03756, USA. givan@dartmouth.edu; Fluorescent dyes that stain cell membranes or cytoplasm and then partition between daughter cells at division have been used in conjunction with flow cytometry to measure the proliferation of cells. In this paper, using peripheral blood mononuclear cells responding to tetanus toxoid, we describe an extension of this d
Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma.: J Invest Dermatol. 1999 Dec;113(6):1047-53. Unique Identifier : AIDSLINE MED/20062981; Skobe M; Brown LF; Tognazzi K; Ganju RK; Dezube BJ; Alitalo K; Detmar M; Cutaneous Biology Research Center, Department of Dermatology,; Massachusetts General Hospital and Harvard Medical School,; Charlestown 02129, USA.; Kaposi s sarcoma is characterized by clusters of spindle-shaped cells that are considered to be tumor cells and by prominent vasculature. Whereas spindle cells are most likely endothelial in origin, it remains controversial whether they are of lymphatic or blood vascular derivation. To test the hypothesis that the lym
1alpha,25-dihydroxycholecalciferol and cyclosporine suppress induction and promote resolution of psoriasis in human skin grafts transplanted on to SCID mice.: J Invest Dermatol. 1999 Dec;113(6):1082-9. Unique Identifier : AIDSLINE MED/20062987; Dam TN; Kang S; Nickoloff BJ; Voorhees JJ; Department of Dermatology, University of Michigan, Ann Arbor,; USA. TNDam@dadlnet.dk; Accumulating evidence has emphasized the importance of immunocompetent cells in determining the psoriatic phenotype. We have investigated the effect of 1alpha,25-dihydroxycholecalciferol, the naturally occurring active form of vitamin D3, cyclosporine A, and interleukin-10 on the phenotype of human psoriatic skin xeno
Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine.: J Infect Dis. 1999 Dec;180(6):1757-62. Unique Identifier : AIDSLINE MED/20027024; Gauthier J; Bourne EJ; Lutz MW; Crowther LM; Dienstag JL; Brown NA; Condreay LD; Department of Virology, Glaxo Wellcome, Inc., Research Triangle; Park, NC 27709, USA. JG38736@glaxowellcome.com; Hepatitis B viremia and emergence of hepatitis B virus (HBV) YMDD variants with reduced susceptibility to lamivudine were analyzed in patient sera from a phase II study of extended lamivudine therapy. Within 12 weeks, all patients exhibited a marked virologic response to lamivudine: >99% reduction (median 5 log decrea
Evidence among blood donors for a 30-year-old epidemic of human T lymphotropic virus type II infection in the United States.: J Infect Dis. 1999 Dec;180(6):1777-83. Unique Identifier : AIDSLINE MED/20027027; Murphy EL; Watanabe K; Nass CC; Ownby H; Williams A; Nemo G; Department of Laboratory Medicine, UCSF Box 0884, San Francisco,; CA 94143, USA. murphy@labmed.ucsf.edu; The demographic and geographic determinants of human T lymphotropic virus types I and II (HTLV-I and -II) are not well defined in the United States . Antibodies to HTLV-I and -II were measured in 1.7 million donors at five US blood centers during 1991-1995. Among those tested, 156 (9.1/
Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. District of Columbia Gay Cohort Study. Multicenter Hemophilia Cohort Study.: J Infect Dis. 1999 Dec;180(6):1784-9. Unique Identifier : AIDSLINE MED/20027028; Engels EA; Rosenberg PS; Biggar RJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, MD 20822, USA.; engelse@exchange.nih.gov; Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n=1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zo
Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort.: J Infect Dis. 1999 Dec;180(6):1790-802. Unique Identifier : AIDSLINE MED/20027029; Greenough TC; Brettler DB; Kirchhoff F; Alexander L; Desrosiers RC; O'Brien SJ; Somasundaran M; Luzuriaga K; Sullivan JL; Program in Molecular Medicine, University of Massachusetts; Medical School, Worcester, MA 01605, USA.; Thomas.Greenough@umass.umed.edu; Seven long-term nonprogressors (LTNPs) have been identified in a cohort of 128 human immunodeficiency virus (HIV)-1 infected individuals with hemophilia. Studies included quantitation of virus by polymerase chain reaction, characterization of primary virus isolates in vitro, analysis of lymphocyte surface markers, and
Association between the rate of CD4+ T cell decrease and the year of human immunodeficiency virus (HIV) type 1 seroconversion among persons enrolled in the Swiss HIV cohort study.: J Infect Dis. 1999 Dec;180(6):1803-8. Unique Identifier : AIDSLINE MED/20027030; Vanhems P; Lambert J; Guerra M; Hirschel B; Allard R; Laboratoire d-Epidemiologie et de Sante Publique, Universite; Claude Bernard Lyon 1, 8. av. Rockefeller, 69373 Lyon Cedex 08,; France. philipva@lyon-sud.univ-lyon1.fr; The aim of this study was to investigate the early CD4+ T cell response among human immunodeficiency virus type 1 (HIV-1) seroconverters in relation to their year of seroconversion. Study participants were enrolled in the Swiss HIV Cohort Study between 1985 and 1995 and had not received antiretroviral treatment. The s
Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era.: J Infect Dis. 1999 Dec;180(6):1809-18. Unique Identifier : AIDSLINE MED/20027031; Martin JN; Rose DA; Hadley WK; Perdreau-Remington F; Lam PK; Gerberding JL; Center for AIDS Prevention Studies and Department of Epidemiology; and Biostatistics, University of California, San Francisco, USA.; martin@psg.ucsf.edu; Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used for Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus (HIV)-infected patients, but little is known about the effects of this practice on the emergence of TMP-SMX-resistant bacteria. A serial cross-sectional study of resistance to TMP-SMX a
Treatment with granulocyte colony-stimulating factor decreases the capacity of hematopoietic progenitor cells for generation of lymphocytes in human immunodeficiency virus-infected persons.: J Infect Dis. 1999 Dec;180(6):1819-26. Unique Identifier : AIDSLINE MED/20027032; Nielsen SD; Clark DR; Hutchings M; Dam-Larsen S; Repping S; Nielsen JO; Mathiesen L; Miedema F; Hansen JE; Laboratory for Infectious Diseases, 144, Hvidovre Hospital, 2650; Hvidovre, Denmark. sdn@dadlnet.dk; An obstacle to stem cell gene therapy for AIDS is the limited numbers of hematopoietic progenitors available. Granulocyte colony-stimulating factor (G-CSF) is used for mobilization of progenitors, but little is known about the functional characteristics of mobilized progenitors, and immature and T cell progenitors may
Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir.: Unique Identifier : AIDSLINE MED/20027033; Lori F; Jessen H; Lieberman J; Finzi D; Rosenberg E; Tinelli C; Walker B; Siliciano RF; Lisziewicz J; RIGHT, Medical-Dental Bldg. SW307, Washington, DC 20007, USA.; RIGHT@gunet.georgetown.edu; Current treatments for human immunodeficiency virus (HIV) require uninterrupted drug administration because they are unable to reconstitute the immune response and do not affect the viral reservoir. Ten patients were treated during acute HIV infection before complete Western blot (WB) seroconversion with the combinati
The effect of increasing alpha1-acid glycoprotein concentration on the antiviral efficacy of human immunodeficiency virus protease inhibitors.: J Infect Dis. 1999 Dec;180(6):1833-7. Unique Identifier : AIDSLINE MED/20027034; Zhang XQ; Schooley RT; Gerber JG; Department of Medicine, Division of Infectious Diseases,; University of Colorado Health Sciences Center, Denver, Colorado,; USA.; The effect of a 4-fold increase in alpha1-acid glycoprotein (AGP) on the antiviral efficacy of 5 human immunodeficiency virus (HIV) protease inhibitors (PIs) was examined by the effect of HIV PIs on p24 production in peripheral blood mononuclear cells infected with
Virus levels in untreated African infants infected with human immunodeficiency virus type 1.: J Infect Dis. 1999 Dec;180(6):1838-43. Unique Identifier : AIDSLINE MED/20027035; Biggar RJ; Janes M; Pilon R; Miotti P; Taha TE; Broadhead R; Mtimivalye L; Kumwenda N; Cassol S; Viral Epidemiology Branch, National Cancer Institute, National; Institute of Allergy and Infectious Diseases, Rockville, MD; 20862, USA. biggarb@epndce.nci.nih.gov; In developed areas, human immunodeficiency virus (HIV)-infected infants have high virus levels and rapidly progress to death. HIV levels were assessed in 1994-1997 in untreated infants in Malawi by analysis of dried blood spots tested by nucleic acid silica-bound amplification. Of
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants.: Unique Identifier : AIDSLINE MED/20027036 P; Rodman JH; Flynn PM; Robbins B; Jimenez E; Bardeguez AD; Rodriguez JF; Blanchard S; Fridland A
Evaluation of distinct blood lymphocyte populations in human immunodeficiency virus type 1-infected subjects in the absence or presence of effective therapy.: J Infect Dis. 1999 Dec;180(6):1851-62. Unique Identifier : AIDSLINE MED/20027037; Derdeyn CA; Kilby JM; Miralles GD; Li LF; Sfakianos G; Saag MS; Hockett RD; Bucy RP; Department of Pathology, University of Alabama at Birmingham,; Birmingham, AL 35233, USA.; Virus reservoirs can persist in human immunodeficiency virus type 1 (HIV-1)-infected subjects despite effective plasma virus suppression. To compare viral dynamics in the absence and presence of antiretroviral therapy, blood mononuclear cells from 19 subjects with high plasma RNA levels and 18 subjects following prolo
Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition.: J Infect Dis. 1999 Dec;180(6):1863-8. Unique Identifier : AIDSLINE MED/20027038; Martin HL; Richardson BA; Nyange PM; Lavreys L; Hillier SL; Chohan B; Mandaliya K; Ndinya-Achola JO; Bwayo J; Kreiss J; Department of Medicine, University of Washington, Seattle, USA.; A prospective cohort study was conducted to examine the relationship between vaginal colonization with lactobacilli, bacterial vaginosis (BV), and acquisition of human immunodeficiency virus type 1 (HIV-1) and sexually transmitted diseases in a population of sex workers in Mombasa, Keny
A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya.: J Infect Dis. 1999 Dec;180(6):1886-93. Unique Identifier : AIDSLINE MED/20027041; Malonza IM; Tyndall MW; Ndinya-Achola JO; Maclean I; Omar S; MacDonald KS; Perriens J; Orle K; Plummer FA; Ronald AR; Moses S; Department of Medical Microbiology, University of Nairobi,; Nairobi City Commission, Nairobi, Kenya.; A randomized, double-blind, placebo-controlled clinical trial was conducted in Nairobi, Kenya , to compare single-dose ciprofloxacin with a 7-day course of erythromycin for the treatment of chancroid. In all, 208 men and 37 women presenting with genital ulcers clinically compatible w
Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses.: Unique Identifier : AIDSLINE MED/20027049 P; Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M
Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation.: J Infect Dis. 1999 Dec;180(6):1987-93. Unique Identifier : AIDSLINE MED/20027052; Moormann AM; Sullivan AD; Rochford RA; Chensue SW; Bock PJ; Nyirenda T; Meshnick SR; Department of Epidemiology, University of Michigan, Ann Arbor,; Michigan, USA.; Malaria infections during pregnancy can lead to the delivery of low-birth-weight infants. In this study, cytokine mRNA was measured in placentas from 23 malaria-infected and 21 uninfected primigravid women who had delivered in Mangochi, Malawi , a region with a high rate of transmis
Waterborne outbreak of intestinal microsporidiosis in persons with and without human immunodeficiency virus infection.: J Infect Dis. 1999 Dec;180(6):2003-8. Unique Identifier : AIDSLINE MED/20027054; Cotte L; Rabodonirina M; Chapuis F; Bailly F; Bissuel F; Raynal C; Gelas P; Persat F; Piens MA; Trepo C; Hepatogastroenterology and AIDS Unit, Hotel-Dieu, 1 Place de; l'Hopital, 69 288 Lyon, France. cotte@univ-lyon1.fr; cotte@univ-lyon1.fr; Among 1454 persons whose stool samples (n=5692) were submitted to a reference laboratory for microsporidia assessment from 1993 to 1996, microsporidia were identified in 338 persons: 261 persons infected with human immunodeficiency virus (HIV), 16 transplant patients, and 61 others. Intestinal
Increase in hepatitis C virus load in hemophiliacs during treatment with highly active antiretroviral therapy.: J Infect Dis. 1999 Dec;180(6):2027-9. Unique Identifier : AIDSLINE MED/20027059; Ragni MV; Bontempo FA; Department of Medicine, University of Pittsburgh School of; Medicine, Pittsburgh, PA, USA. ragni@msx.dept-med.pitt.edu; The effect of highly active antiretroviral therapy (HAART) on liver function and viral load of hepatitis C virus (HCV) was studied in 21 hemophilic men coinfected with HCV and human immunodeficiency virus (HIV). HCV RNA polymerase chain reaction was measured by branched DNA Quantiplex assay on frozen plasma samples ob
High levels of viremia in patients with the Hantavirus pulmonary syndrome.: J Infect Dis. 1999 Dec;180(6):2030-4. Unique Identifier : AIDSLINE MED/20027060; Terajima M; Hendershot JD 3rd; Kariwa H; Koster FT; Hjelle B; Goade D; DeFronzo MC; Ennis FA; Center for Infectious Disease and Vaccine Research, University of; Massachusetts Medical School, Worcester, Massachusetts, USA.; Hantavirus pulmonary syndrome (HPS) is a rare but acute fulminant disease caused by Sin Nombre virus (SNV). To understand the role of the viral load in the pathogenesis of HPS, the load of virus in the blood of patients with HPS was measured. A quantitative reverse transcription-polymerase chain reaction assay was dev
Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.: J Infect Dis. 1999 Dec;180(6):2039-43. Unique Identifier : AIDSLINE MED/20027062; Pereira AS; Kashuba AD; Fiscus SA; Hall JE; Tidwell RR; Troiani L; Dunn JA; Eron JJ Jr; Cohen MS; Department of Pathology, School of Medicine, University of North; Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Human immunodeficiency virus (HIV) can be transmitted in semen from a man to his sexual partners. Antiretroviral drugs are likely to affect the amount of HIV-1 in semen and perhaps transmission of the virus. The concentrations of zidovudine, lamivudine, and HIV-1 RNA in blood and seminal plasma were measured in 9 HIV-
Circulating autoantibodies to erythropoietin are associated with human immunodeficiency virus type 1-related anemia.: J Infect Dis. 1999 Dec;180(6):2044-7. Unique Identifier : AIDSLINE MED/20027063; Sipsas NV; Kokori SI; Ioannidis JP; Kyriaki D; Tzioufas AG; Kordossis T; Department of Pathophysiology, Laikon General Hospital and School; of Medicine, National and Kapodistrian University of Athens,; Athens, Greece. nsipsas@otenet.gr; In a cohort of 204 unselected consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients, the association of circulating autoantibodies to endogenous erythropoietin (EPO) with HIV-1-related anemia was studied. Circulating autoantibodies to EPO were present in 48 (23.5%) of the 204 patients studied. Circ
Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy.: J Infect Dis. 1999 Dec;180(6):2069-73. Unique Identifier : AIDSLINE MED/20027069; Hirsch CS; Toossi Z; Othieno C; Johnson JL; Schwander SK; Robertson S; Wallis RS; Edmonds K; Okwera A; Mugerwa R; Peters P; Ellner JJ; Case Western Reserve University, Department of Medicine, Division; of Infectious Diseases, Cleveland, OH 44106-4984, USA.; cxh40@po.cwru.edu; Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency virus (HIV)-uninfected and HIV-infected patients, with newly diagnosed pulmonary tuberculosis (TB), and tuberculin-skin-test-reactive healthy control subjects. HIV-uninfected patients with TB were also followed up longitudinally dur
An unusual case of Pneumocystis carinii presenting as an aural mass.: J Laryngol Otol. 1999 Jun;113(6):555-7. Unique Identifier : AIDSLINE MED/20073520; Patel SK; Philpott JM; McPartlin DW; Department of Otolaryngology-Head and Neck Surgery, St Mary's; Hospital, London, UK.; Extrapulmonary involvement of organs with the protozoan Pneumocystis carinii is rare. We describe a case of Pneumocystis carinii presenting as an erosive aural mass in a young male patient with acquired immunodeficiency syndrome. As far as the authors are aware such an example has never been described in a British jou
The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation.: J Leukoc Biol. 1999 Dec;66(6):996-1004. Unique Identifier : AIDSLINE MED/20080446; Schabath R; Muller G; Schubel A; Kremmer E; Lipp M; Forster R; Max-Delbruck-Center for Molecular Medicine, Berlin, Germany.; We have characterized the murine homolog of the HIV-co-receptor CXCR4 during T cell development and activation. Our data demonstrate that this chemokine receptor, although highly conserved between human and mouse, is differently expressed and regulated in both species. Mitogenic activation resulted in an increase of s
Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo.: J Exp Med. 1999 Dec 6;190(11):1561-72. Unique Identifier : AIDSLINE MED/20054497; Suzuki H; Zhou YW; Kato M; Mak TW; Nakashima I; Department of Immunology, Nagoya University School of Medicine,; Nagoya 466-8550, Japan. k46200a@nucc.cc.nagoya-u.ac.jp; Although interleukin 2 ( IL-2 ) has been thought to be the most important cytokine for T cell growth, animals lacking IL-2 or a component of its receptor molecules have more expanded T cells with activated memory phenotype, indicating an indispensable role for the IL-2/I
Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47.: J Exp Med. 1999 Dec 6;190(11):1605-16. Unique Identifier : AIDSLINE MED/20054501; Bain G; Quong MW; Soloff RS; Hedrick SM; Murre C; Department of Biology, University of California, San Diego, La; Jolla, California 92093, USA.; The E2A proteins, E12 and E47, are required for progression through multiple developmental pathways, including early B and T lymphopoiesis. Here, we provide in vitro and in vivo evidence demonstrating that E47 activity regulates double-positive thymocyte maturation. In the absence of E47 activity, positive selection o
Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.: J Exp Med. 1999 Dec 6;190(11):1647-56. Unique Identifier : AIDSLINE MED/20054505; Michie AM; Trop S; Wiest DL; Zuniga-Pflucker JC; Department of Immunology, University of Toronto, Toronto, Ontario; M5S 1A8, Canada.; The first checkpoint in T cell development occurs between the CD4(-)CD8(-) and CD4(+)CD8(+) stages and is associated with formation of the pre-T cell receptor (TCR). The signaling mechanisms that drive this progression remain largely unknown. Here, we show that extracellular signal-regulated kinases (ERKs)-1/2 are act
Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma.: J Exp Med. 1999 Dec 6;190(11):1669-78. Unique Identifier : AIDSLINE MED/20054507; Thurner B; Haendle I; Roder C; Dieckmann D; Keikavoussi P; Jonuleit H; Bender A; Maczek C; Schreiner D; von den Driesch P; Brocker EB; Steinman RM; Enk A; Kampgen E; Schuler G; Department of Dermatology, University of Erlangen-Nuremberg,; D-91052 Erlangen, Germany.; Dendritic cells (DCs) are considered to be promising adjuvants for inducing immunity to cancer. We used mature, monocyte-derived DCs to elicit resistance to malignant melanoma. The DCs were pulsed with Mage-3A1 tumor peptide and a recall antigen, tetanus toxoid or tuberculin. 11 far advanced stage IV melanoma patients
Transcriptional activation of human TR3/nur77 gene expression by human T-lymphotropic virus type I Tax protein through two AP-1-like elements.: J Gen Virol. 1999 Dec;80 ( Pt 12):3073-81. Unique Identifier : AIDSLINE MED/20036620; Liu X; Chen X; Zachar V; Chang C; Ebbesen P; Department of Virus and Cancer, Danish Cancer Society, Gustav; Wieds Vej 10, DK-8000 Aarhus C, Denmark. liu@virus.au.dk; The Tax transactivator of human T-lymphotropic virus type I (HTLV-I) is capable of inducing expression of the human immediate-early TR3/nur77 gene. Deletion and mutation analyses of the TR3/nur77 promoter demonstrated that multiple transcription elements in the 121 bp sequence proximal to the transcription start site
First seroepidemiological study and phylogenetic characterization of human T-cell lymphotropic virus type I and II infection among Amerindians in French Guiana.: J Gen Virol. 1999 Dec;80 ( Pt 12):3083-8. Unique Identifier : AIDSLINE GENBANK/AF063818; Talarmin A; Vion B; Ureta-Vidal A; Du Fou G; Marty C; Kazanji M; Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, BP; 6010, 23 Av. Pasteur, 97300 Cayenne, French Guiana.; We investigated the serological, epidemiological and molecular aspects of human T-cell lymphotropic virus type I and II (HTLV-I/II) infection in the Amerindian populations of French Guiana by testing 847 sera. No HTLV-II antibodies
Specific passage of simian immunodeficiency virus from end-stage disease results in accelerated progression to AIDS in rhesus macaques.: J Gen Virol. 1999 Dec;80 ( Pt 12):3089-97. Unique Identifier : AIDSLINE MED/20036622; Holterman L; Niphuis H; ten Haaft PJ; Goudsmit J; Baskin G; Heeney JL; Department of Virology, Biomedical Primate Research Centre, Lange; Kleiweg 157, 2288 GJ, Rijswijk, The Netherlands.; To determine whether passage of late-stage variants of simian immunodeficiency virus (SIV) would lead to a more virulent infection and rapid disease progression, a study was designed to examine the effects of selective transmission of SIV from late-stage cases of AIDS in Macaca mulatta. In a uniform group of 10 age-ma
The human herpesvirus-8 ORF 57 gene and its properties.: J Gen Virol. 1999 Dec;80 ( Pt 12):3207-15. Unique Identifier : AIDSLINE MED/20036636; Bello LJ; Davison AJ; Glenn MA; Whitehouse A; Rethmeier N; Schulz TF; Barklie Clements J; Institute of Virology, University of Glasgow, Church Street,; Glasgow G11 5JR, UK.; Human herpesvirus-8 (HHV-8) is a gamma(2) lymphotropic herpesvirus associated with Kaposi s sarcoma, a major neoplasm of AIDS patients, and with other AIDS-related neoplasms. The HHV-8 ORF 57 gene is conserved throughout the herpesvirus family and has a herpes simplex virus type 1 homologue, IE63 (also termed ICP27),
Cervical shedding of cytomegalovirus in human immunodeficiency virus type 1-infected women.: J Med Virol. 1999 Dec;59(4):469-73. Unique Identifier : AIDSLINE MED/20006008; Mostad SB; Kreiss JK; Ryncarz AJ; Overbaugh J; Mandaliya K; Chohan B; Ndinya-Achola J; Bwayo JJ; Corey L; Department of Epidemiology, University of Washington, Seattle,; Washington 98195, USA.; Cervical shedding of cytomegalovirus ( CMV ) is important in transmission of CMV to exposed sexual partners and neonates. We evaluated prevalence and correlates of CMV DNA shedding in cervical secretions from a large cohort of
Prevalence of long-term BK and JC excretion in HIV-infected adults and lack of correlation with serological markers.: J Med Virol. 1999 Dec;59(4):474-9. Unique Identifier : AIDSLINE MED/20006009; Knowles WA; Pillay D; Johnson MA; Hand JF; Brown DW; Enteric and Respiratory Virus Laboratory, Central Public Health; Laboratory, London, England. wknowles@phls.nhs.uk; The natural history of polyomavirus infection, and sensitivity of diagnostic assays remain unclear. A stratified group of 94 human immunodeficiency virus (HIV)-infected patients was studied for both virological and serological markers of active infection with both JC virus and BK virus. JC DNA was detected in the urin
Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors.: J Med Virol. 1999 Dec;59(4):480-90. Unique Identifier : AIDSLINE +; Cabana M; Clotet B; Martinez MA; Fundacio irsiCaixa, Laboratori de Retrovirologia, Hospital; Universitari Germans Trias i Pujol, Badalona, Spain.; The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure. Complex mutational
Presence of human herpesviruses 6, 7, and 8 DNA sequences in normal brain tissue.: Unique Identifier : AIDSLINE MED/20006011; Chan PK; Ng HK; Hui M; Ip M; Cheung JL; Cheng AF; Department of Microbiology, Chinese University of Hong Kong,; Prince of Wales Hospital, Shatin, New Territories, Hong Kong,; China. paulkschan@cuhk.edu.hk; The three novel human herpesviruses (HHV) 6, 7, and 8 are predominantly, but not exclusively, lymphotropic. In an attempt to elucidate their neurotropism in vivo, viral DNA sequences present in fresh autopsy cortical brain tissues obtained from 84 consecutive Chinese subjects (mean age, 66.9 years; range, 21-98 years)
Human herpesviruses 6 and 7 as potential pathogens after liver transplant: prospective comparison with the effect of cytomegalovirus.: Unique Identifier : AIDSLINE MED/20006012 P; Griffiths PD; Ait-Khaled M; Bearcroft CP; Clark DA; Quaglia A; Davies SE; Burroughs AK; Rolles K; Kidd IM; Knight SN; Noibi SM
Mutations conferring resistance to zidovudine diminish the antiviral effect of stavudine plus didanosine.: J Med Virol. 1999 Dec;59(4):507-11. Unique Identifier : AIDSLINE MED/20006014; Izopet J; Bicart-See A; Pasquier C; Sandres K; Bonnet E; Marchou B; Puel J; Massip P; Laboratoire de Virologie, Hopital Purpan, Toulouse Cedex,; France. izopet@cict.fr; This study evaluated the influence of zidovudine (ZDV) resistance mutations on the antiviral effect of the combination of stavudine (D4T) plus didanosine (ddI) in patients treated previously with ZDV plus zalcitabine (
Estimating the time of HTLV-I infection following mother-to-child transmission in a breast-feeding population in Jamaica.: J Med Virol. 1999 Dec;59(4):541-6. Unique Identifier : AIDSLINE MED/20006019; Furnia A; Lal R; Maloney E; Wiktor S; Pate E; Rudolph D; Waters D; Blattner W; Manns A; George Washington University, School of Public Health and Health; Services, Washington, DC, USA.; Mother-to-child transmission of human T-cell lymphotropic virus type I (HTLV-I) is primarily due to prolonged breast-feeding (>6 months) in the postnatal period. Most infant infections are not identifiable until 12 to 18 months of age by available whole virus Western blot serologic tests because of their inability to
Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi's sarcoma.: J Clin Oncol. 1999 Jun;17(6):1876-83. Unique Identifier : AIDSLINE MED/20029957; Gill PS; Tulpule A; Espina BM; Cabriales S; Bresnahan J; Ilaw M; Louie S; Gustafson NF; Brown MA; Orcutt C; Winograd B; Scadden DT; Departments of Medicine and Pharmacy, University of Southern; California, Kenneth Norris Cancer Hospital and Research; Institute, Los Angeles, CA, USA. parkashg@hsc.usc.edu; PURPOSE: Liposomal anthracyclines are the present standard treatment for advanced AIDS-related Kaposi s sarcoma (KS). No effective therapies have been defined for use after treatment failure of these agents. A phase II trial was thus conducted with paclitaxel in patients with advanced KS to assess safety and antitumor
SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef.: J Mol Biol. 1999 Nov 12;293(5):1097-106. Unique Identifier : AIDSLINE MED/20016380; Hiipakka M; Poikonen K; Saksela K; Institute of Medical Technology, University of Tampere, Tampere,; FIN-33101, Finland.; The avid binding of HIV-1 Nef to the Src homology-3 (SH3) domain of Hck (KD 250 nM) has been shown to involve an interaction between the RT-loop of Hck-SH3 and residues in Nef outside of its prototypic polyproline type II (PPII) helix-containing SH3-ligand region. Such distinctive interactions are thought to provide s
Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and Moloney murine leukemia virus reverse transcriptase.: J Mol Biol. 1999 Dec 17;294(5):1097-113. Unique Identifier : AIDSLINE MED/20069932; Gao HQ; Sarafianos SG; Arnold E; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Frederick, MD 21702-1201, USA.; Retroviral revXerse transcriptases (RTs) have an associated RNase H activity that can cleave RNA-DNA duplexes with considerable precision. We believe that the structure of the RNA-DNA duplexes in the context of RT determines the specificity of RNase H cleavage. To test this idea, we treated three related groups of syn
Cellular compartments of human immunodeficiency virus type 1 replication in vivo: determination by presence of virion-associated host proteins and impact of opportunistic infection.: J Virol. 2000 Jan;74(1):139-45. Unique Identifier : AIDSLINE MED/20057905; Lawn SD; Roberts BD; Griffin GE; Folks TM; Butera ST; HIV and Retrovirology Branch, Division of AIDS, STD, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; Antigens derived from host cells are detectable in the envelope of human immunodeficiency virus type 1 (HIV-1) and result in a distinctive viral phenotype reflecting that of the host cell. An immunomagnetic capture assay targeting discriminatory host proteins was developed to differentiate between HIV-1 derived from m
Roles of matrix, p2, and N-terminal myristoylation in human immunodeficiency virus type 1 Gag assembly.: Unique Identifier : AIDSLINE MED/20057891; Morikawa Y; Hockley DJ; Nermut MV; Jones IM; The Kitasato Institute, Minato-ku, Tokyo 108-8642, Japan.; ymorikawa@kitasato.or.jp; Human immunodeficiency virus type 1 Gag protein is cotranslationally myristoylated at the N terminus and targeted to the plasma membrane, where virus particle assembly occurs. Particle assembly requires the ordered multimerization of Gag proteins, yet there is little direct evidence of intermediates of the reaction or
RNA dimerization defect in a Rous sarcoma virus matrix mutant.: J Virol. 2000 Jan;74(1):164-72. Unique Identifier : AIDSLINE MED/20057908; Parent LJ; Cairns TM; Albert JA; Wilson CB; Wills JW; Craven RC; Department of Medicine, The Pennsylvania State University College; of Medicine, M. S. Hershey Medical Center, Hershey, Pennsylvania; 17033, USA.; The retrovirus matrix (MA) sequence of the Gag polyprotein has been shown to contain functions required for membrane targeting and binding during particle assembly and budding. Additional functions for MA have been proposed based on the existence of MA mutants in Rous sarcoma virus (RSV), murine leukemia virus, human
Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease.: J Virol. 2000 Jan;74(1):184-92. Unique Identifier : AIDSLINE MED/20057910; Schramm B; Penn ML; Speck RF; Chan SY; De Clercq E; Schols D; Connor RI; Goldsmith MA; Gladstone Institute of Virology and Immunology, University of; California San Francisco, San Francisco, California 94141-9100,; USA.; The chemokine receptors CCR5 and CXCR4 function as the principal coreceptors for human immunodeficiency virus type 1 (HIV-1). Coreceptor function has also been demonstrated for a variety of related receptors in vitro. The relative contributions of CCR5, CXCR4, and other putative coreceptors to HIV-1 disease in vivo ha
Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains.: Unique Identifier : AIDSLINE MED/20057918; Liao HX; Etemad-Moghadam B; Montefiori DC; Sun Y; Sodroski J; Scearce RM; Doms RW; Thomasch JR; Robinson S; Letvin NL; Haynes BF; We have compared the abilities of human immunodeficiency virus type 1 (HIV-1) envelope V3 peptides and recombinant gp120 to induce antibodies that neutralize simian/human immunodeficiency viruses (SHIVs). SHIV-89.6 is a nonpathogenic SHIV that expresses the envelope protein of primary HIV-1 isolate 89.6. SHIV-89.6P, c
Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120.: J Virol. 2000 Jan;74(1):326-33. Unique Identifier : AIDSLINE MED/20057926; Salzwedel K; Smith ED; Dey B; Berger EA; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; We devised an experimental system to examine sequential events by which the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) interacts with CD4 and coreceptor to induce membrane fusion. Recombinant soluble CD4 (sCD4) activated fusion between effector cells expressing Env and target cells express
Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.: J Virol. 2000 Jan;74(1):344-53. Unique Identifier : AIDSLINE MED/20057928; Mitola S; Soldi R; Zanon I; Barra L; Gutierrez MI; Berkhout B; Giacca M; Bussolino F; Institute for Cancer Research and Treatment, 10060 Candiolo,; Italy.; Human immunodeficiency virus type 1 (HIV-1) Tat transactivates viral genes and is released by infected cells, acting as a soluble mediator. In endothelial cells (EC), it activates a proangiogenic program by activating vascular endothelial growth factor receptor type 2 (VEGFR-2) and integrins. A structure-activity rela
Simplified strategy for detection of recombinant human immunodeficiency virus type 1 group M isolates by gag/env heteroduplex mobility assay. Study Group on Heterogeneity of HIV Epidemics in African Cities.: J Virol. 2000 Jan;74(1):363-70. Unique Identifier : AIDSLINE MED/20057930; Heyndrickx L; Janssens W; Zekeng L; Musonda R; Anagonou S; Van der Auwera G; Coppens S; Vereecken K; De Witte K; Van Rampelbergh R; Kahindo M; Morison L; McCutchan FE; Carr JK; Albert J; Essex M; Goudsmit J; Asjo B; Salminen M; Buve A; van Der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; We developed a heteroduplex mobility assay in the gag gene (gag HMA) for the identification of group M subtypes A to H. The assay covers the region coding for amino acid 132 of p24 to amino acid 20 of p7 (according to human immunodeficiency virus type 1 [HIV-1] ELI, 460 bp). The gag HMA was compared with sequencing an
Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles.: J Virol. 2000 Jan;74(1):371-8. Unique Identifier : AIDSLINE MED/20057931; Davis NL; Caley IJ; Brown KW; Betts MR; Irlbeck DM; McGrath KM; Connell MJ; Montefiori DC; Frelinger JA; Swanstrom R; Johnson PR; Johnston RE; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill, North Carolina 27599, USA.; joiner@med.unc.edu; Vaccine vectors derived from Venezuelan equine encephalitis virus (VEE) that expressed simian immunodeficiency virus (SIV) immunogens were tested in rhesus macaques as part of the effort to design a safe and effective vaccine for human immunodeficiency virus. Immunization with VEE replicon particles induced both humor
Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.: J Virol. 2000 Jan;74(1):428-35. Unique Identifier : AIDSLINE MED/20057937; Hanabuchi S; Ohashi T; Koya Y; Kato H; Takemura F; Hirokawa K; Yoshiki T; Yagita H; Okumura K; Kannagi M; Department of Immunotherapeutics, Tokyo Medical and Dental; University, Medical Research Division, Japan.; Host immunity influences clinical manifestations of human T-cell leukemia virus type 1 (HTLV-1) infection. In this study, we demonstrated that HTLV-1-transformed tumors could develop in immunocompetent rats by blocking a costimulatory signal for T-cell immune responses. Four-week-old WKA/HKm rats were treated with mon
Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome.: J Virol. 2000 Jan;74(1):436-46. Unique Identifier : AIDSLINE MED/20057938; Choi JK; Lee BS; Shim SN; Li M; Jung JU; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). K15 isolates from body cavity-based lymphoma (BCBL) cells exhibited a dramatic sequence variation and a complex splicing pattern. However, all
Role of the cytoplasmic tail of ecotropic moloney murine leukemia virus Env protein in fusion pore formation.: J Virol. 2000 Jan;74(1):447-55. Unique Identifier : AIDSLINE MED/20057939; Melikyan GB; Markosyan RM; Brener SA; Rozenberg Y; Cohen FS; Department of Molecular Biophysics and Physiology, Rush Medical; College, Chicago, Illinois 60612, USA.; Fusion between cells expressing envelope protein (Env) of Moloney murine leukemia virus and target cells were studied by use of video fluorescence microscopy and electrical capacitance measurements. When the full-length 632-amino-acid residue Env was expressed, fusion did not occur at all for 3T3 cells as target and o
cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.: J Virol. 2000 Jan;74(1):483-92. Unique Identifier : AIDSLINE MED/20057943; Olivetta E; Pugliese K; Bona R; D'Aloja P; Ferrantelli F; Santarcangelo AC; Mattia G; Verani P; Federico M; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; F12 human immunodeficiency virus type 1 (HIV-1) nef is a naturally occurring nef mutant cloned from the provirus of a nonproductive, nondefective, and interfering HIV-1 variant (F12-HIV). We have already shown that cells stably transfected with a vector expressing the F12-HIV nef allele do not downregulate CD4 recepto
env sequences of simian immunodeficiency viruses from chimpanzees in Cameroon are strongly related to those of human immunodeficiency virus group N from the same geographic area.: J Virol. 2000 Jan;74(1):529-34. Unique Identifier : AIDSLINE GENBANK/AF135497; Corbet S; Muller-Trutwin MC; Versmisse P; Delarue S; Ayouba A; Lewis J; Brunak S; Martin P; Brun-Vezinet F; Simon F; Barre-Sinoussi F; Mauclere P; Unite de Biologie des Retrovirus, Institut Pasteur, Paris,; France.; Human immunodeficiency virus type 1 (HIV-1) group N from Cameroon is phylogenetically close, in env, to the simian immunodeficiency virus (SIV) cpz-gab from Gabon and SIVcpz-US of unknown geographic origin. We screened 29 wild-born Cameroonian
A heterologous, high-affinity RNA ligand for human immunodeficiency virus Gag protein has RNA packaging activity.: J Virol. 2000 Jan;74(1):541-6. Unique Identifier : AIDSLINE MED/20057951; Clever JL; Taplitz RA; Lochrie MA; Polisky B; Parslow TG; Departments of Pathology, University of California, San; Francisco, California 94143-0506, USA.; Retroviral RNA encapsidation depends on the specific binding of Gag proteins to packaging (psi) signals in genomic RNA. We investigated whether an in vitro-selected, high-affinity RNA ligand for the nucleocapsid (NC) portion of the Gag protein from human immunodeficiency virus type 1 (HIV-1) could mediate packaging in
Immune complexes containing human immunodeficiency virus type 1 primary isolates bind to lymphoid tissue B lymphocytes and are infectious for T lymphocytes.: J Virol. 2000 Jan;74(1):552-5. Unique Identifier : AIDSLINE MED/20057953; Jakubik JJ; Saifuddin M; Takefman DM; Spear GT; Department of Immunology/Microbiology, Rush University, Chicago,; Illinois 60612, USA.; This study investigated the interaction of tonsil B lymphocytes with immune complexes containing human immunodeficiency virus (HIV IC) primary isolates and the infectivity of the B cell-bound HIV IC. Treatment of virus with a source of antibody and complement increased HIV IC binding to B cells by 5.6-fold. Most of th
Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo.: J Virol. 2000 Jan;74(1):57-64. Unique Identifier : AIDSLINE MED/20057896; Veazey RS; Tham IC; Mansfield KG; DeMaria M; Forand AE; Shvetz DE; Chalifoux LV; Sehgal PK; Lackner AA; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772, USA.; ronald_veazey@hms.harvard.edu; It has recently been shown that rapid and profound CD4(+) T-cell depletion occurs almost exclusively within the intestinal tract of simian immunodeficiency virus (SIV)-infected macaques within days of infection. Here we demonstrate (by three- and four-color flow cytometry) that this depletion is specific to a definabl
Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells.: J Virol. 2000 Jan;74(1):65-73. Unique Identifier : AIDSLINE MED/20057897; Schwartz C; Catez P; Rohr O; Lecestre D; Aunis D; Schaeffer E; Unite 338 INSERM, 67084 Strasbourg Cedex, France.; Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system (CNS) and plays a direct role in the pathogenesis of AIDS dementia . However, mechanisms underlying HIV-1 gene expression in the CNS are poorly understood. The importance of CCAAT/enhancer binding protein
Erasmus, syphilis, and the abuse of stigma.: Lancet. 1999 Dec 18-25;354(9196):2147-8. Unique Identifier : AIDSLINE MED/20075922; Whitty CJ; Department of Medicine, College of Medicine, University of; Malawi, Blantyre. c.whitty@lshtm.ac.uk
Guidelines for national human immunodeficiency virus case surveillance, including monitoring for human immunodeficiency virus infection and acquired immunodeficiency syndrome. Centers for Disease Control and Prevention.: Unique Identifier : AIDSLINE MED/20096158; CDC recommends that all states and territories conduct case surveillance for human immunodeficiency virus (HIV) infection as an extension of current acquired immunodeficiency syndrome (AIDS) surveillance activities. The expansion of national surveillance to include both HIV infection and AIDS cases is a necessary resp
The Rous sarcoma virus Env glycoprotein contains a highly conserved motif homologous to tyrosine-based endocytosis signals and displays an unusual internalization phenotype.: Mol Cell Biol. 2000 Jan;20(1):249-60. Unique Identifier : AIDSLINE MED/20063185; Ochsenbauer C; Dubay SR; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.; The cytoplasmic domains of retroviral transmembrane (TM) glycoproteins contain conserved sequence motifs that resemble tyrosine-based (YXXO-type) endocytosis signals. We have previously described a mutant Rous sarcoma virus (RSV) Env protein, Env-mu26, with an L165R mutation in the membrane-spanning domain (MSD) of TM
South Africa doubles budget for medical research and AIDS [news]: Nature. 1999 Dec 23-30;402(6764):850. Unique Identifier : AIDSLINE MED/20085959
p53 inhibition by the LANA protein of KSHV protects against cell death.: Nature. 1999 Dec 23-30;402(6764):889-94. Unique Identifier : AIDSLINE MED/20085966; Friborg J Jr; Kong W; Hottiger MO; Nabel GJ; Vaccine Research Center, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, has been implicated in the development of Kaposi s sarcoma (KS) and several B-cell lymphoproliferative diseases. Most cells in lesions derived from these malignancies are latently infected, and different viral gene products have been identified in
Immunohistochemical analysis of HLA class II antigens and tumor infiltrating mononuclear cells in renal cell carcinoma: correlation with clinical and histopathological data.: Neoplasma. 1999;46(3):173-8. Unique Identifier : AIDSLINE MED/20078754; Brasanac D; Markovic-Lipkovski J; Hadzi-Djokic J; Muller GA; Muller CA; Institute of Pathology, School of Medicine, University of; Belgrade, Yugoslavia.; Cryostat sections of 37 renal cell carcinomas (RCC)--25 clear cell type, 10 granular and 2 chromophobe--were studied with indirect immunoperoxidase method applying monoclonal antibodies (MoAb) to HLA-DR, -DP and -DQ antigens for analysis of HLA class II antigens, and anti-CD14, -CD3, -CD4 and -CD8 MoAb for tumor infil
Evaluation of 2-(methylaminosulfonyl)-1-(arylsulfonyl)hydrazines as anticancer agents.: Neoplasma. 1999;46(4):242-5. Unique Identifier : AIDSLINE MED/20078766; Ghosh M; Dutta S; Sanyal U; Department of Anticancer Drug Development and Chemotherapy,; Chittaranjan National Cancer Institute, Calcutta, India.; Seven new 2-(methylaminosulfonyl)- 1-(arylsulfonyl)hydrazines were prepared and evaluated as potential antitumor agents in vivo against murine Ehrlich ascites carcinoma (EAC). Borderline in vivo activity in EAC was exhibited by two compounds. All of them were screened in vitro against a battery of human tumor cell lin
Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms.: Oncogene. 1999 Dec 9;18(52):7543-51. Unique Identifier : AIDSLINE MED/20071138; Macho A; Calzado MA; Jimenez-Reina L; Ceballos E; Leon J; Munoz E; Departamento de Fisiologia e Inmunologia, Universidad de; Cordoba, Facultad de Medicina, Avda. de Menendez Pidal s/n,; 14071 Cordoba, Spain.; The effects of HIV-1 Tat protein on mitochondria membrane permeability and apoptosis were analysed in lymphoid cells. In this report we show that stable-transfected HIV-Tat cells are primed to undergo apoptosis upon serum withdrawal. This effect was observed in both the Jhan T cell line and the K562 cells, the latter
RN continues advancing health care worker safety.: Pa Nurse. 1998 Apr;53(4):6. Unique Identifier : AIDSLINE MED/20081505; Arnold L
Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men.: Pharmacotherapy. 1999 Dec;19(12):1378-84. Unique Identifier : AIDSLINE MED/20067069; Polk RE; Crouch MA; Israel DS; Pastor A; Sadler BM; Chittick GE; Symonds WT; Gouldin W; Lou Y; Department of Pharmacy, Virginia Commonwealth University/Medical; College of Virginia Campus, Richmond, USA.; STUDY OBJECTIVE: To determine the effects of coadministration of amprenavir and ketoconazole on the pharmacokinetics of both drugs, and to assess the utility of the erythromycin breath test (ERMBT) to predict and explain these effects. DESIGN: Open-label, randomized, balanced, single-dose, three-period crossover study
Potential interaction between itraconazole and clarithromycin.: Pharmacotherapy. 1999 Dec;19(12):1439-44. Unique Identifier : AIDSLINE MED/20067077; Auclair B; Berning SE; Huitt GA; Peloquin CA; Department of Medicine, National Jewish Center for Immunology and; Respiratory Medicine, University of Colorado, Denver 80206, USA.; Three patients negative for human immunodeficiency virus infection were admitted for pulmonary Mycobacterium avium complex (MAC) and aspergillosis infections. They were treated with different drug combinations, but all regimens included clarithromycin for MAC and itraconazole for aspergillosis. All patients experience
Emotional distress and occupational burnout in health care professionals serving HIV-infected patients: A comparison with oncology and internal medicine services.: Psychother Psychosom. 1999;68(6):348-56. Unique Identifier : AIDSLINE MED/20027601; Lopez-Castillo J; Gurpegui M; Ayuso-Mateos JL; Luna JD; Catalan J; Department of Psychiatry and Institute of Neurosciences,; University of Granada Medical School, Granada, Spain.; BACKGROUND: The present paper examines the levels of emotional distress and professional burnout among health care professionals working with HIV patients in two different settings, Infectious Disease (ID) Units and a Haemophilia (H) Unit, and compares them with those of professionals working in Oncology (O) or Genera
CD4 counts of HIV-positive patients with cognitive disorders in Japan [letter]: Psychosomatics. 1999 Nov-Dec;40(6):529. Unique Identifier : AIDSLINE MED/20048687; Fukunishi I; Hirabayashi N; Fukutake K
[Chronic viral hepatitis caused by B and C virus: diagnostic and therapeutic trends (editorial)]: Recenti Prog Med. 1999 Nov;90(11):595-600. Unique Identifier : AIDSLINE MED/20075477; Saracco G; Rizzetto M
Removal of silicone oil with vision improvement after rhegmatogenous retinal detachment following CMV retinitis in patients with AIDS.: Retina. 1999;19(6):495-8. Unique Identifier : AIDSLINE MED/20072463; Schaller UC; MacDonald JC; Mueller AJ; Karavellas MP; Klauss V; Scheider A; Kampik A; Freeman WR; University Eye Hospital, Munich, Germany.; PURPOSE: To report that silicone oil may be safely removed from immuno-recovered patients with acquired immunodeficiency syndrome (AIDS) after instillation for cytomegalovirus ( CMV )-related rhegmatogenous retinal detachment.
[Antiviral treatment of hepatitis C virus infection]: Rev Med Interne. 1999 Aug;20 Suppl 3:331s-340s. Unique Identifier : AIDSLINE MED/99409552; Silvain C; Service d'hepato-gastroenterologie et d'assistance nutritive,; CHU Jean Bernard, Poitiers, France.; Hepatitis C virus infection is common and almost always chronic and can lead to cirrhosis and hepatocellular cancer. The primary goal of the treatment is virus eradication and the secondary is to reduce inflammation and liver cell damage. Interferon is the only effective therapy but disappearance of the virus is susta
NIMH. Mental health agency shrugs off critics [news]: Science. 1999 Dec 17;286(5448):2248. Unique Identifier : AIDSLINE MED/20093967; Holden C
Humoral and cellular immune responses to HIV-1 nef in mice DNA-immunised with non-replicating or self-replicating expression vectors.: Vaccine. 1999 Oct 14;18(5-6):460-7. Unique Identifier : AIDSLINE MED/99451180; Collings A; Pitkanen J; Strengell M; Tahtinen M; Lagerstedt A; Hakkarainen K; Ovod V; Sutter G; Ustav M; Ustav E; Mannik A; Ranki A; Peterson P; Krohn K; Institute of Medical Technology, University of Tampere, Tampere,; Finland.; OBJECTIVE: HIV accessory protein Nef is expressed early in the infectious cycle of the virus and has been shown to be an effective immunogen in humoral and cellular immune responses. We have used two different self-replicating pBN vectors and one non-replicating pCGal2 derived (pCG) vector expressing HIV-1 Nef in DNA
Protective effects against simian immunodeficiency virus agm (SIVagm) infection in cynomolgus monkeys immunized with a recombinant vaccinia virus expressing the SIVagm envelope gene.: Vaccine. 1999 Oct 14;18(5-6):511-6. Unique Identifier : AIDSLINE MED/99451186; Ibuki K; Ido E; Funahashi S; Miura T; Hayami M; Shida H; Department of Cell Biology, Institute for Virus Research, Kyoto; University, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan.; Protective immunity induced by a recombinant vaccinia virus expressing the envelope (Env) protein of a simian immunodeficiency virus strain, SIVagm, (SEN-RVV), was evaluated in cynomolgus monkeys (Macaca fascicularis). Three monkeys were immunized twice with SEN-RVV and boostered with the purified SIVagm Env protein.
Needle-free, non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatitis B virus.: Vaccine. 1999 Oct 14;18(5-6):517-23. Unique Identifier : AIDSLINE MED/99451187; Misra A; Ganga S; Upadhyay P; National Institute of Immunology, Aruna Asaf Ali Marg, New Dehli,; India.; To explore the feasibility of non-adjuvanted, needle-free skin immunization, we examined the immune responses of mice immunized by three routes with two antigens (Ag) differing in molecular size and lipophilicity. Diphtheria toxoid (DT) or a myristylated peptide (MYR) administered either by transdermal electroporation
Antibodies against pneumococcal polysaccharides after vaccination in HIV-infected individuals: 5-year follow-up of antibody concentrations.: Vaccine. 1999 Oct 14;18(5-6):524-30. Unique Identifier : AIDSLINE MED/99451188; Kroon FP; van Dissel JT; Ravensbergen E; Nibbering PH; van Furth R; Department of Infectious Diseases, Leiden University Medical; Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.; kroonfp@xs4all/nl; We studied the production of IgG antibodies against eight pneumococcal polysaccharide serotypes (PPS) 1, 4, 6B, 9V, 14, 18C, 19F and 23F after vaccination of 50 HIV-infected adults with 23-valent Pneumovax((R))23 and the course of the antibodies against four PPS during the following years. Mean antibody concentrations
Biological dynamics of viral load in hemodialysis patients with hepatitis C virus.: Am J Kidney Dis. 2000 Jan;35(1):122-9. Unique Identifier : AIDSLINE MED/20089080; Fabrizi F; Martin P; Dixit V; Brezina M; Cole MJ; Vinson S; Mousa M; Gitnick G; Division of Digestive Diseases, University of California at Los; Angeles School of Medicine, Los Angeles, USA.; The biological dynamics of hepatitis C virus (HCV) viremia in uremic patients with chronic infection have not been fully characterized. We prospectively studied fluctuations of HCV-RNA in sera from 52 patients with end-stage renal disease who were undergoing maintenance hemodialysis (HD) and had chronic HCV infection.
Circulating levels of transforming growth factor-beta1 and lymphokines among children with hemolytic uremic syndrome.: Am J Kidney Dis. 2000 Jan;35(1):29-34. Unique Identifier : AIDSLINE MED/20089067; Proulx F; Litalien C; Turgeon JP; Mariscalco MM; Seidman E; Department of Pediatrics, Sainte-Justine Hospital, University of; Montreal, Montreal, Canada. sip@point-net.com; Verotoxin-producing Escherichia coli (VTEC) cause hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The aim of this study was to compare the circulating levels of transforming growth factor-beta 1 (TGF-beta1), T helper (T(H))1 (interferon [IFN]-gamma, interleukin [IL]-2), and T(H)2-associated lymphokines (
[Cutaneous CD8 lymphocyte infiltration syndrome associated with human immunodeficiency virus infection (editorial)]: Ann Dermatol Venereol. 1999 Oct;126(10):673-4. Unique Identifier : AIDSLINE MED/20071669; Bachelez H
["Buffalo hump" related to indinavir treatment]: Ann Dermatol Venereol. 1999 Oct;126(10):720-2. Unique Identifier : AIDSLINE MED/20071681; Dornier C; Posth M; Granel F; Barbaud A; Schmutz JL; Service de Dermatologie, Hopital Fournier, Nancy.; BACKGROUND: Since 1997, new side effects like lipodystrophia have been described in HIV-1-infected patients treated with protease inhibitors . The evolution is not specified in the most reported cases. CASE REPORT: A 44-year-old man treated for HIV 1 infection develo
Characterization of the antiviral effect of 2',3'-dideoxy-2', 3'-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model.: Antimicrob Agents Chemother. 2000 Jan;44(1):111-22. Unique Identifier : AIDSLINE MED/20068684; Le Guerhier F; Pichoud C; Guerret S; Chevallier M; Jamard C; Hantz O; Li XY; Chen SH; King I; Trepo C; Cheng YC; Zoulim F; INSERM Unit 271, 69003 Lyon, France.; A novel L-nucleoside analog of deoxycytidine, 2 ,3 -dideoxy-2 , 3 -didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), was recently shown to strongly inhibit hepatitis B virus (HBV) replication in the 2.2.15 cell line. Therefore, its antiviral activity was evaluated in the duck HBV (DHBV) infection model. Using a cell-fr
Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.: Antimicrob Agents Chemother. 2000 Jan;44(1):123-30. Unique Identifier : AIDSLINE MED/20068685; Szczech GM; Furman P; Painter GR; Barry DW; Borroto-Esoda K; Grizzle TB; Blum MR; Sommadossi J; Endoh R; Niwa T; Yamamoto M; Moxham C; Triangle Pharmaceuticals, Inc., Durham, North Carolina 27707,; USA. szczecgm@tripharm.com; Emivirine (EMV), formerly known as MKC-442, is 6-benzyl-1-(ethoxymethyl)-5-isopropyl-uracil, a novel nonnucleoside reverse transcriptase inhibitor that displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity in vivo. EMV showed little or no toxicity towards human mitochondria or human b
Successful treatment with nitazoxanide of Enterocytozoon bieneusi microsporidiosis in a patient with AIDS.: Antimicrob Agents Chemother. 2000 Jan;44(1):167-8. Unique Identifier : AIDSLINE MED/20068693; Bicart-See A; Massip P; Linas MD; Datry A; Department of Infectious and Tropical Diseases, Purpan Hospital,; Toulouse, France. bicart@club-internet.fr; A patient with AIDS and chronic diarrhea caused by Enterocytozoon bieneusi was successfully treated with nitazoxanide, producing a complete clinical and parasitological response, while off of antiviral therapy. This suggests that nitazoxanide may be effective in treating m
Activities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages.: Antimicrob Agents Chemother. 2000 Jan;44(1):173-7. Unique Identifier : AIDSLINE MED/20068695; Aquaro S; Wedgwood O; Yarnold C; Cahard D; Pathinara R; McGuigan C; Calio' R; de Clercq E; Balzarini J; Perno CF; Department of Experimental Medicine, University of Rome Tor; Vergata, Rome, Italy.; The anti-human immunodeficiency virus (HIV) activity of aryloxyphosphoramidate protides of a number of anti-HIV nucleoside analogues was assessed in resting primary monocyte-macrophages (M/M). While 2 ,3 -dideoxythymidine ( d4T ), 2 ,3 -dideoxyadenosine
Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP.: Antimicrob Agents Chemother. 2000 Jan;44(1):217-21. Unique Identifier : AIDSLINE MED/20068708; Vaccaro JA; Parnell KM; Terezakis SA; Anderson KS; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06520-8066, USA.; Among the clinically used nucleoside analogue inhibitors that target human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), there is little detailed mechanistic information on the interactions of 2 ,3 -didehydro-2 , 3 -dideoxythymidine-5 -triphosphate (d4TTP) with the enzyme. primer-template complex a
The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis.: Antimicrob Agents Chemother. 2000 Jan;44(1):51-6. Unique Identifier : AIDSLINE MED/20068675; Blanco J; Barretina J; Henson G; Bridger G; De Clercq E; Clotet B; Este JA; Institut de Recerca de la SIDA-Caixa, Laboratori de; Retrovirologia, Hospital Universitari Germans Trias i Pujol,; 08916 Badalona, Catalonia, Spain. jblanco@ns.hugtip.scs.es; Infection by human immunodeficiency virus type 1 (HIV-1) has been associated with increased cell death by apoptosis in infected and uninfected cells. The envelope glycoprotein complex ([gp120/gp41](n)) of X4 HIV-1 isolates is involved in both infected and uninfected cell death via its interaction with cellular recepto
Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate.: Antiviral Res. 1999 Oct;43(3):157-73. Unique Identifier : AIDSLINE MED/20017536; Krebs FC; Miller SR; Malamud D; Howett MK; Wigdahl B; Department of Microbiology and Immunology, The Pennsylvania State; University, College of Medicine, Hershey 17033, USA.; A highly desirable approach to prevention of human immunodeficiency virus type 1 (HIV-1) transmission during sexual intercourse is the development of nontoxic, topical, broad spectrum microbicides effective against transmission of cell-associated and cell-free virus. Toward this end, the HIV-1 inactivation potential o
Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells.: Antiviral Res. 1999 Oct;43(3):189-99. Unique Identifier : AIDSLINE MED/20017538; Fujiwara M; Okamoto M; Okamoto M; Watanabe M; Machida H; Shigeta S; Konno K; Yokota T; Baba M; Rational Drug Design Laboratories, Fukushima, Japan.; In our extensive screening of anti-HIV-1 agents in chronically infected cell lines, we have found acridone derivatives to be selective inhibitors of HIV-1 replication. Among the acridone derivatives, 1-hydroxy-10-methyl-9,10-dihydroacrid-9-one (RD6-5071) suppressed tumor necrosis factor (TNF)-alpha-induced HIV-1 expre
Decreasing occupational risk related to blood-borne viruses in cardiovascular surgery in Paris, France.: Ann Thorac Surg. 1999 Dec;68(6):2267-72. Unique Identifier : AIDSLINE MED/20083305; Kuo YH; Fabiani JN; Mohamed AS; Couetil JP; Levy M; Gutmann L; Carpentier AF; Belec L; Laboratoire de Virologie, Service de Chirurgie Cardiovasculaire,; Hopital Broussais, Paris, France.; BACKGROUND: Surgeons face the risk of patient-to-physician transmission of blood-borne viruses. This risk is related to the seroprevalence of the viruses in the patient population. METHODS: The seroprevalence of the human immunodeficiency virus, hepatitis B virus, and hepatitis C virus were determined in cardiovascula
[Antibiotic growth promoters for the view of animal nutrition]: Berl Munch Tierarztl Wochenschr. 1999 Oct-Nov;112(10-11):370-9. Unique Identifier : AIDSLINE MED/20066301; Kamphues J; Institut fur Tierernahrung, Tierarztlichen Hochschule; Hannover.; From 01. 07./09. 1999 on six further antibiotic growth promoters have been banned--with only four substances remaining in this group of feed additives. Therefore, the discussion on a possible induction of bacterial resistance by antibiotic growth promoters, especially in potentially pathogenic bacteria, will sooner or
Two interaction modes of the gp41-derived peptides with gp41 and their correlation with antimembrane fusion activity.: Biochem Biophys Res Commun. 1999 Nov 30;265(3):625-9. Unique Identifier : AIDSLINE MED/20070801; Ryu JR; Jin BS; Suh MJ; Yoo YS; Yoon SH; Woo ER; Yu YG; Structural Biology Center, Bioanalysis and Biotransformation; Research Center, Medicinal Chemistry Research Center, Korea; Institute of Science and Technology, PO Box 131, Cheongryang,; Seoul, 130-650, Korea.; Peptides derived from gp41 effectively block the gp41-mediated cell fusion or HIV infection. A 36-mer (naDP178), 51-mer (C51) and 27-mer peptide (C27) from the membrane proximal region of gp41 have been examined their interaction modes with the coiled-coil motif of gp41 presented in thioredoxin (Trx-N) or the bacteria
Prevention of bacterial infections in patients with advanced HIV infection.: AIDS. 1999;13 Suppl 2:S19-23. Unique Identifier : AIDSLINE MED/20061791; Mitsuyasu R; Center for Clinical AIDS Research and Education, University of; California, Los Angeles 90095-1793, USA. rmitsuya@mednet.ucla.edu; In a study of 258 moderately neutropenic HIV-infected patients, Filgrastim (recombinant methionyl human granulocyte colony-stimulating factor) treatment significantly reduced the incidence of severe neutropenia and bacterial infections. Filgrastim-treated patients also had 54% fewer severe bacterial infections and 45%
Filgrastim treatment of HIV-infected patients improves neutrophil function.: AIDS. 1999;13 Suppl 2:S25-30. Unique Identifier : AIDSLINE MED/20061792; Pitrak DL; Section of Infectious Diseases, University of Illinois at; Chicago, 60612, USA.; The effect of Filgrastim (recombinant methionyl human granulocyte colony-stimulating factor) treatment on neutrophil function was studied in HIV-infected patients. Filgrastim therapy significantly increased oxidative capacity of neutrophils, increased bacterial killing, and reduced accelerated apoptosis of neutrophils
Granulocyte colony-stimulating factor: its potential role in infectious disease.: Unique Identifier : AIDSLINE MED/20061789; Hartung T; University of Konstanz, Biochemical Pharmacology, Germany.; Thomas.Hartung@UNI-Konstanz.DE; Studies on the role of endogenous granulocyte colony-stimulating factor (G-CSF) in host defense indicate that, in addition to its anti-infectious role, this cytokine has an immunomodulatory function and also augments antibiotic efficacy. Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-C
Thalidomide for the treatment of acquired immunodeficiency syndrome-associated refractory oral ulcers.: Arch Otolaryngol Head Neck Surg. 2000 Jan;126(1):89-92. Unique Identifier : AIDSLINE MED/20092300; Diz Dios P; Sopena B; Cameselle J; Butron M; Crespo M; Ocampo A; Special Needs Unit, School of Medicine and Dentistry, Santiago de; Compostela University, Santiago de Compostela, Spain. pdiz@usc.es; A case of severe, oral, not otherwise specified ulcers in a human immunodeficiency virus-infected patient is described. The lesions did not respond to acyclovir , prednisone, pentoxifylline, or foscarnet sodium therapy. Dramatic clinical improvement and progressive ulcer healing
Superantigens are presented by and activate thymocytes from infants.: Exp Clin Immunogenet. 1999;16(4):226-33. Unique Identifier : AIDSLINE MED/20044445; Thulesen S; Jorgensen A; Gerwien J; Dohlsten M; Holst Nissen M; Odum N; Ropke C; Institute of Medical Anatomy Section A, The Panum Institute,; University of Copenhagen, Denmark.; A high percentage of human fetal and postnatal thymocytes express MHC class II molecules. This raises the possibility that human thymocytes in early life are able to present peptides to other immature T cells and thereby initiate thymic selection of these cells. Here we address this question by exposing newly harveste
Intrapatient variability of HIV type 1 group O ANT70 during a 10-year follow-up.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1325-32. Unique Identifier : AIDSLINE MED/99443170; Janssens W; Nkengasong J; Heyndrickx L; Van der Auwera G; Vereecken K; Coppens S; Willems B; Beirnaert E; Fransen K; Peeters M; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; HIV-1 ANT70 is the first HIV-1 group O virus isolate obtained from a 25-year-old Cameroonian woman, who seroconverted in March 1987. This individual has remained asymptomatic and clinically healthy (clinical stage WHO 1, CDC II) even though she did not receive any antiretroviral therapy for HIV-1 before 97 months post
Hydroxyurea and didanosine long-term treatment prevents HIV breakthrough and normalizes immune parameters.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1333-8. Unique Identifier : AIDSLINE MED/99443171; Lori F; Rosenberg E; Lieberman J; Foli A; Maserati R; Seminari E; Alberici F; Walker B; Lisziewicz J; Research Institute for Genetic and Human Therapy, Policlinico S.; Matteo, Pavia, Italy.; Hydroxyurea and didanosine treatment suppressed HIV replication for more than 2 years, in the absence of viral breakthrough, in chronically infected patients. The profile of viral load reduction was unusual for a two-drug combination, since a continuous gradual decrease in viremia persisted despite residual viral repl
The benign cystic lymphoepithelial lesion of the parotid gland is a viral reservoir in HIV type 1-infected patients.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1339-44. Unique Identifier : AIDSLINE MED/99443172; Uccini S; Riva E; Antonelli G; D'Offizi G; Prozzo A; Angelici A; Faggioni A; Angeloni A; Torrisi MR; Gentile M; Baroni CD; Ruco LP; Department of Experimental Medicine and Pathology, University La; Sapienza, Rome, Italy.; The presence of HIV-1 in cystic fluid aspirates from six cases of benign cystic lymphoepithelial lesion (BLL) of the parotid gland, a rare disorder affecting HIV-1-infected patients, has been investigated. HIV-1 p24 protein was present at a concentration ranging from 3 to 15 ng/ml, while it was undetectable in the per
Spontaneous activation of human immunodeficiency virus type 1 in an immunotoxin-resistant variant T cell line.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1345-9. Unique Identifier : AIDSLINE MED/99443173; Fang H; Pincus S; Department of Microbiology, Montana State University, Bozeman; 59717-3520, USA.; We have previously used immunotoxins to select for HIV-1 variant cells that transcribe HIV at extremely low levels and fail to produce HIV proteins. Further observation of one of these variants (E9) demonstrated spontaneous in vitro activation of HIV production. The mechanism of activation is different from that of U1
Influence of Rex and intronic sequences on expression of spliced mRNAs produced by human T cell leukemia virus type I.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1351-63. Unique Identifier : AIDSLINE MED/99443174; D'Agostino DM; Ciminale V; Zotti L; Chieco-Bianchi L; Department of Oncology and Surgical Sciences, University of; Padova, Italy. dmdago@ux1.unipd.it; Expression of the incompletely spliced HTLV-I mRNAs relies on the viral posttranscriptional activator Rex, whose interaction with the Rex-responsive element (RXRE) overcomes effects of cis-acting repressive sequences (CRSs). Studies based on heterologous reporter plasmids identified an intronic CRS in the 5 LTR and a
Comparison of the distribution of IgG and IgA antibodies in serum and various mucosal fluids of HIV type 1-infected subjects.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1365-76. Unique Identifier : AIDSLINE MED/99443175; Raux M; Finkielsztejn L; Salmon-Ceron D; Bouchez H; Excler JL; Dulioust E; Grouin JM; Sicard D; Blondeau C; Pasteur Merieux Connaught, Val de Reuil, France.; mraux@fr.pmc-vacc.com; We compared IgG and IgA distribution in serum, three different salivary samples, two different rectal secretion samples, cervicovaginal secretions, and seminal secretions from asymptomatic CDC stage II/III HIV-1-infected subjects (n = 44) and from HIV-1-seronegative volunteers (n = 52). In-house ELISAs were used to me
Investigation of recombinant human insulin-like growth factor type I in thymus regeneration in the acute stage of experimental FIV infection in juvenile cats.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1377-88. Unique Identifier : AIDSLINE MED/99443176; Woo JC; Dean GA; Lavoy A; Clark R; Moore PF; Department of Pathology, Microbiology, and Immunology, School of; Veterinary Medicine, University of California, Davis 95616, USA.; Thymus involvement and the development of thymic lesions in HIV-1 infection is hypothesized to suppress thymus function and limit T cell maturation and replenishment of the peripheral lymphoid pool. Therapeutic modulation to protect or enhance thymus function may therefore ameliorate peripheral lymphocytopenia and ret
Simian AIDS-associated lymphoma in rhesus and cynomolgus monkeys recapitulates the primary pathobiological features of AIDS-associated non-Hodgkin's lymphoma.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1389-98. Unique Identifier : AIDSLINE MED/99443177; Habis A; Baskin GB; Murphey-Corb M; Levy LS; Department of Microbiology and Immunology, and Tulane Cancer; Center, Tulane University Medical Center, New Orleans, Louisiana; 70112, USA.; Non-Hodgkin s lymphomas occur with increased frequency (3-6%) in HIV-infected individuals. These AIDS-associated lymphomas (AALs) exhibit characteristics that distinguish them from lymphomas in the general population. A proposed model for the pathogenesis of AAL includes the following: (1) Tumorigenesis is multistep;
Alterations in the V1/V2 domain of HIV-2CBL24 glycoprotein 105 correlate with an extended cell tropism.: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1399-402. Unique Identifier : AIDSLINE GENBANK/AJ239000; Vella C; King D; Zheng NN; Fickenscher H; Breuer J; Daniels RS; School of Biological Sciences, Queen Mary & Westfield College,; London, UK. c.vella@qmw.ac.uk
Increase in activated CD4+ lymphocytes with CCR5 and CXCR4 in HIV type 1-infected persons [letter]: AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1403-4. Unique Identifier : AIDSLINE MED/99443179; Auewarakul P; Sangsiriwut K; Pattanapanyasat K; Suwanagool S; Wasi C
Targeting HIV reservoirs and reconstituting the immune system. Second annual meeting Research Institute for Genetic and Human Therapy April 18-19, 1999 Washington, DC.: Vaccines, DNA/IMMUNOLOGY AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1597-617. Unique Identifier : AIDSLINE MED/20072099; Lori F; Lisziewicz J; Anti-Ri antibodies most often occur in patients with breast cancer and typically are associated with the paraneoplastic syndrome of opsoclonus-myoclonus-ataxia. This study reports a patient with diplopia and ophthalmoplegia. She had anti-Ri antibodies, and despite an exhaustive search for malignancy at presentation, b
Oropharyngeal candidiasis in patients with HIV: suggested guidelines for therapy.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1619-23. Unique Identifier : AIDSLINE MED/20072100; Powderly WG; Gallant JE; Ghannoum MA; Mayer KH; Navarro EE; Perfect JR; Washington University Medical School, St Louis, Missouri 63110,; USA.; The high frequency of oropharyngeal candidiasis in immunocompromised patients has led many institutions to develop protocols to guide the use of antifungal agents in the treatment of this opportunistic infection. However, few specific recommendations have been made for directing the management of oropharyngeal candidi
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1625-30. Unique Identifier : AIDSLINE MED/20072101; Chen H; Schinazi RF; Rajagopalan P; Gao Z; Chu CK; McClure HM; Boudinot FD; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens 30602, USA.; (-)-beta-D-Dioxolane guanine (DXG) is a nucleoside analog possessing potent activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), and hepatitis B virus (HBV) in vitro. Owing to the limited aqueous solubility of DXG, (-)-beta-D-2,6-diaminopurine dioxolane (DAPD), a more water-soluble prodrug
Incidence and predictors of virologic failure of antiretroviral triple-drug therapy in a community-based cohort.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1631-8. Unique Identifier : AIDSLINE MED/20072102; Paris D; Ledergerber B; Weber R; Jost J; Flepp M; Opravil M; Ruef C; Zimmerli S; Department of Medicine, University Hospital, Zurich, Switzerland.; Highly active antiretroviral therapy fails to reach its recommended goal of sustained suppression of viral replication in a substantial proportion of patients. We analyzed incidence and predictors of virologic failure of the first regimen of a triple-drug combination thera
HIV type 1 infection of human fetal bone marrow cells induces apoptotic changes in hematopoietic precursor cells and suppresses their in vitro differentiation and capacity to engraft SCID mice.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1639-52. Unique Identifier : AIDSLINE MED/20072103; Yurasov SV; Pettoello-Mantovani M; Raker CA; Goldstein H; Department of Pediatrics, Albert Einstein College of Medicine,; Bronx, New York 10461, USA.; To investigate the mechanism of HIV-1-induced hematopoietic abnormalities, we examined the effect of HIV-1 infection on the in vitro and in vivo behavior of precursor cells obtained from human fetal bone marrow (HFBM). After infection with the monocyte-tropic isolate HIV-1(ADA), HFBM cells displayed a significant decr
Differential patterns of interaction between HIV type 1 and HTLV type I in monocyte-derived macrophages cultured in vitro: implications for in vivo coinfection with HIV type 1 and HTLV type I.: Unique Identifier : AIDSLINE MED/20072104; Szabo J; Beck Z; Csoman E; Liu X; Andriko I; Kiss J; Basci A; Ebbesen P; Toth FD; Institute of Microbiology, University Medical School, Debrecen,; Hungary.; The interaction between human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia-lymphoma virus type I (HTLV-I) has generated substantial interest. However, there is disagreement on the in vivo consequences of the double infection. We investigated the interactions between HIV-1 and HTLV-I in monocyte-deri
New reporter cell lines to study macrophage-tropic HIV envelope protein-mediated cell-cell fusion.: Unique Identifier : AIDSLINE MED/20072105 P; Hong YL; Wu LH; Cui M
Genetic analysis reveals ongoing HIV type 1 evolution in infected human placental trophoblast.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1673-83. Unique Identifier : AIDSLINE MED/20072106; Zachar V; Zacharova V; Fink T; Thomas RA; King BR; Ebbesen P; Jones TB; Goustin AS; Department of Virus and Cancer, Danish Cancer Society, Aarhus.; vladimir@virus.aau.dk; To provide a better understanding of the role of placenta in vertical human immunodeficiency virus (HIV) transmission, we have studied the infection of placental trophoblast in a group of 15 mother-neonate pairs. By nested PCR amplification of the C2V3 env gene region, HIV-1 has been found to infect the placenta in fi
Antibody and cellular immune responses in breakthrough infection subjects after HIV type 1 glycoprotein 120 vaccination.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1685-9. Unique Identifier : AIDSLINE GENBANK/AF197872; Locher CP; Grant RM; Collisson EA; Reyes-Teran G; Elbeik T; Kahn JO; Levy JA; Department of Medicine, University of California, San Francisco; 94143, USA.; HIV-specific antibodies and CD8+ T cell antiviral responses were evaluated in three human immunodeficiency virus 1 (HIV-1) gp120 vaccine recipients who later became infected with HIV-1. Titers of neutralizing antibody to the HIV-1(SF2) vaccine isolate were boosted, but titers of antibody to the autologous infecting vi
Retrospective analysis of viral load and SIV antibody responses in rhesus macaques infected with pathogenic SIV: predictive value for disease progression.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1691-701. Unique Identifier : AIDSLINE MED/20072108; Smith SM; Holland B; Russo C; Dailey PJ; Marx PA; Connor RI; St Michael's Medical Center, Newark, New Jersey 07102, USA.; ssmith1824@aol.com; The prognostic significance of SIV plasma viral load in macaques has not been well established, primarily owing to the small numbers of animals in experimental groups. In addition, many investigators have noted that animals that fail to develop an anti-SIV humoral response develop disease rapidly. To establish the pro
Sequence features downstream of the primer-binding site of HIV type 1 subtype E shared by subtype G and a subset of subtype A.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1703-6. Unique Identifier : AIDSLINE GENBANK/AF164485; Chang SY; Apichartpiyakul C; Kuiken CL; Essex M; Lee TH; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115, USA.; Two distinct sequence features downstream of the primer-binding site (PBS) were identified in a full-length HIV-1 subtype E clone amplified in this study. Both features are frequently found in HIV-1 subtypes A and G and in more than half of the full-length intersubtype recombinant clones. One of these is the absence o
The identification of a complex A/G/I/J recombinant HIV type 1 virus in various West African countries.: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1707-12. Unique Identifier : AIDSLINE GENBANK/AJ245487; Montavon C; Bibollet-Ruche F; Robertson D; Koumare B; Mulanga C; Esu-Williams E; Toure C; Mboup S; Saman E; Delaporte E; Peeters M; Laboratoire Retrovirus, Institut pour le Recherche en; Developement, Montpellier, France.; In this sequence note we describe the full-length genome sequence of an HIV-1 isolate originating from the west African country of Mali . The phylogenetic tree analysis from the near full-length genome shows that the 95ML84 strain forms a separate cluster, supported by 100% of the boo
Alteration of complement protein levels after antiretroviral therapy in HIV-infected persons [letter]: AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1713-5. Unique Identifier : AIDSLINE MED/20072111; Spear GT; Olinger G; Sullivan BL; Landay AL; Kessler H; Connick E; Kuritzkes D; St Clair M; Spritzler J; Wu H; Lederman MM
Preventive therapy against tuberculosis in people living with HIV.: Wkly Epidemiol Rec. 1999 Nov 19;74(46):385-98. Unique Identifier : AIDSLINE MED/20077979
Nucleic acid sequence discrimination by the HIV-1 nucleocapsid protein NCp7: a fluorescence study.: Biochemistry. 1999 Dec 21;38(51):16816-25. Unique Identifier : AIDSLINE MED/20074531; Vuilleumier C; Bombarda E; Morellet N; Gerard D; Roques BP; Mely Y; Laboratoire de Pharmacologie et Physico-Chimie des Interactions; Cellulaires et Moleculaires, UMR 7034 CNRS, Faculte de; Pharmacie, Universite Louis Pasteur, Strasbourg, France.; The critical functions of the HIV-1 nucleocapsid protein NCp7 in genomic RNA packaging and reverse transcription, essentially rely on interactions with nucleic acids. A significant progress in the knowledge of these interactions has been recently achieved with the NMR-derived structures of NCp7 derivatives in complex
Structural requirements for potent human spermicidal activity of dual-function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).: Biol Reprod. 2000 Jan;62(1):37-44. Unique Identifier : AIDSLINE MED/20078917; D'Cruz OJ; Venkatachalam TK; Uckun FM; Drug Discovery Program, Departments of Reproductive Biology,; Chemistry, and. Virology, Hughes Institute, St. Paul, Minnesota; 55113, USA. odcruz@ih.org; WHI-07, a novel bromo-methoxy-substituted aryl phosphate derivative of zidovudine (ZDV), is a potent dual-function contraceptive agent. Although the bromo-methoxy functional groups in the thymine ring of its ZDV are very important for its sperm-immobilizing activity (SIA), the importance of the esterification of the p
Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS.: Neuroreport. 1999 Nov 26;10(17):3513-5. Unique Identifier : AIDSLINE MED/20084653; Sardar AM; Hutson PH; Reynolds GP; Department of Biomedical Science, University of Sheffield, UK.; HIV infection frequently leads to neurological deficits and is associated with neuronal loss and damage. We have investigated two neurochemical indicators of the integrity of glutamatergic systems in brain tissue taken postmortem from the frontal cortex of AIDS patients and age-matched controls. NMDA receptor density
High rate of maternal-infant transmission of hepatitis G virus in HIV-1 and hepatitis C virus-infected women.: Acta Paediatr. 1999 Dec;88(12):1392-5. Unique Identifier : AIDSLINE MED/20089954; Palomba E; Bairo A; Tovo PA; Department of Paediatrics, University of Turin, Italy.; The prevalence of hepatitis G virus (HGV) infection was investigated in 56 mothers with both human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection. Thirty-three (58.8%) women had markers of HGV infection, including 7/15 (46.6%) with no history of parenteral exposure to blood. Sixteen (48%)
Israel health minister bans AIDS campaign promoting condoms [news]: BMJ. 1999 Dec 4;319(7223):1455. Unique Identifier : AIDSLINE MED/20050382; Siegel-Itzkovich J
North-South research in developing countries must respond to community's priorities [letter]: BMJ. 1999 Dec 4;319(7223):1496. Unique Identifier : AIDSLINE MED/20050404; Wilson D
Cryptosporidiosis in a tertiary care hospital.: Natl Med J India. 1999 Sep-Oct;12(5):207-9. Unique Identifier : AIDSLINE MED/20079823; Sethi S; Sehgal R; Malla N; Mahajan RC; Postgraduate Institute of Medical Education and Research,; Chandigarh, India.; BACKGROUND: Cryptosporidium, an important cause of diarrhoea, has been reported worldwide both in immunocompetent and immunocompromised individuals and has emerged as a serious public health problem. This study was undertaken to assess the present status of cryptosporidiosis in children and adults with diarrhoea who a
Inhibition of thymopoiesis of CD34+ cell maturation by HIV-1 in an in vitro CD34+ cell and thymic epithelial organ culture model.: Stem Cells. 1999;17(6):327-38. Unique Identifier : AIDSLINE MED/20072177; Knutsen AP; Roodman ST; Freeman JJ; Mueller KR; Bouhasin JD; Division of Allergy/Immunology, St Louis University Health; Sciences Center, Missouri 63110, USA.; The mechanisms by which HIV-1 affects thymopoiesis were determined by preincubating CD34+ cells or cultured thymic epithelial (CTE) cells with lymphotropic (T-) and monotropic (M-) strains of HIV-1 in an in vitro CTE organ and CD34+ cell coculture model that allows for analysis of development of thymocytes and mature
In vivo and in vitro comparison of the short-term hematopoietic toxicity between hydroxyurea and trimidox or didox, novel ribonucleotide reductase inhibitors with potential anti-HIV-1 activity.: Stem Cells. 1999;17(6):345-56. Unique Identifier : AIDSLINE MED/20072179; Mayhew CN; Phillips JD; Greenberg RN; Birch NJ; Elford HL; Gallicchio VS; School of Health Sciences, University of Wolverhampton, United; Kingdom.; Inhibitors of the cellular enzyme ribonucleotide reductase (hydroxyurea, [HU]) have been proposed as a new therapeutic strategy for the treatment of HIV type-1 (HIV-1) infection. However, HU use may be limited by the frequent development of hematopoietic toxicity. We report here short-term hematopoietic toxicity in mi
The food of sweet and bitter fancy [news]: Nat Struct Biol. 2000 Jan;7(1):17-8. Unique Identifier : AIDSLINE MED/20091074; Putnam CD; Tainer JA; The MAP30 ribosomal inactivating protein structure has been determined by NMR spectroscopy. This anti-HIV and anti-cancer protein is an RNA and DNA glycosylase as well as a DNA apurinic/apyrimidinic (AP) lyase.
Thematic review series. XI: Viruses in the origin of human cancer. Introduction and overview.: Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):560-2. Unique Identifier : AIDSLINE MED/20058613; Gallo RC; Institute of Human Virology, University of Maryland, Baltimore,; USA.
Human retroviruses: their role in cancer.: Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):563-72. Unique Identifier : AIDSLINE MED/20058614; Blattner WA; Institute of Human Virology, University of Maryland, Baltimore; 21201, USA.; Viruses are etiologically linked to approximately 20% of all malignancies worldwide. Retroviruses account for approximately 8%-10% of the total. For human T-cell leukemia virus 1 (HTLV-I), the viral regulatory tax gene product is responsible for enhanced transcription of viral and cellular genes that promote cell grow
Human herpesvirus 8: is it a tumor virus?: Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):594-601. Unique Identifier : AIDSLINE MED/20058618; Neipel F; Albrecht JC; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany.; Human herpesvirus 8 (HHV-8), also termed Kaposi s sarcoma-associated herpesvirus, was identified in Kaposi s sarcoma (KS) biopsy specimens in 1994. The epidemiological data available to date indicate a strong association of HHV-8 with KS. It appears that HHV-8 is necessary for KS development. HHV-8 DNA is invariably f
A ten year serological survey of hepatitis A, B and C viruses infections in Nepal.: J Epidemiol. 1999 Nov;9(5):350-4. Unique Identifier : AIDSLINE MED/20083642; Sawayama Y; Hayashi J; Ariyama I; Furusyo N; Kawasaki T; Kawasaki M; Itoh K; Acharya GP; Kashiwagi S; Department of General Medicine, Kyushu University Hospital,; Faculty of Medicine, Fukuoka, Japan.; BACKGROUND: In 1987, we reported that the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Nepal was low, as compared to hepatitis A virus (HAV) infection, and that no human T-lymphotropic type-1 (HTLV-
Adjuvant effect of a 14-member macrolide antibiotic on DNA vaccine.: Cell Immunol. 1999 Nov 1;197(2):145-50. Unique Identifier : AIDSLINE MED/20076355; Sato Y; Shishido H; Kobayashi H; Takeda J; Irisawa A; Miyata M; Nishimaki T; Fujita T; Kasukawa R; Department of Internal Medicine II, Fukushima Medical University; School of Medicine, Fukushima, 960-1295, Japan.; med2fmc@po.sphere.ne.jp; Macrolide antibiotics have unique immunomodulatory actions apart from their antimicrobial properties. We examined the effect of erythromycin (EM), a 14-member macrolide, on the immune response to a DNA vaccine that induces a T-helper-1 (Th1)-biased immune response through a Th1-promoting adjuvant effect of unmethylate
Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients.: Cell Immunol. 1999 Nov 1;197(2):91-8. Unique Identifier : AIDSLINE MED/20076349; Sondergaard SR; Ullum H; Skinhoj P; Pedersen BK; Department of Infectious Diseases M, Rigshospitalet, Copenhagen,; Denmark.; HIV infection is known to cause changes in phenotype and function of natural killer (NK) cells. The aim of this study was to characterize the NK cells mobilized from peripheral reservoirs in human immunodeficiency virus (HIV)-infected patients and controls. Seventeen HIV-infected patients and eight age- and sex-matche
Charge modification of plasma and milk proteins results in antiviral active compounds.: J Pept Sci. 1999 Dec;5(12):563-76. Unique Identifier : AIDSLINE MED/20092237; Swart PJ; Harmsen MC; Kuipers ME; Van Dijk AA; Van Der Strate BW; Van Berkel PH; Nuijens JH; Smit C; Witvrouw M; De Clercq E; de Bethune MP; Pauwels R; Meijer DK; Groningen University Institute for Drug Exploration, Department; of Pharmacokinetics and Drug Delivery, University Centre for; Pharmacy, The Netherlands. swart.nl@yamanouchi-eu.com; Previous studies have shown that acylated plasma and milk proteins with increased negative charge, derived from various animal and human sources, are potent anti-HIV compounds. The antiviral effects seemed to correlate positively with the number of negative charges introduced into the various polypeptides: proteins wi
Maternal and infant factors predicting disease progression in human immunodeficiency virus type 1-infected infants. Women and Infants Transmission Study Group.: Pediatrics. 2000 Jan;105(1):e8. Unique Identifier : AIDSLINE MED/20085381; Rich KC; Fowler MG; Mofenson LM; Abboud R; Pitt J; Diaz C; Hanson IC; Cooper E; Mendez H; Department of Pediatrics, University of Illinois at Chicago,; Illinois, USA. kenrich@uic.edu; BACKGROUND: Infants with perinatally acquired human immunodeficiency virus type 1 (HIV-1) infection have widely variable courses. Previous studies showed that a number of maternal and infant factors, when analyzed separately, are associated with infant HIV-1 disease progression. In this study, clincal, virologic, and
Alterations in cardiac and pulmonary function in pediatric rapid human immunodeficiency virus type 1 disease progressors. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Study Group.: Pediatrics. 2000 Jan;105(1):e9. Unique Identifier : AIDSLINE MED/20085382; Shearer WT; Lipshultz SE; Easley KA; McIntosh K; Pitt J; Quinn TC; Kattan M; Goldfarb J; Cooper E; Bryson Y; Kovacs A; Bricker JT; Peavy H; Mellins RB; Heart N; Institute LB; Baylor College of Medicine, Houston, Texas, USA.; wshearer@bcm.tmc.edu; OBJECTIVE: Infants with human immunodeficiency virus type 1 (HIV-1) can be divided into rapid progressors (RPs) and non-rapid progressors (non-RPs) based on symptoms and immunologic status, but detailed information about cardiac and pulmonary function in RP and non-RP children needs to be adequately described. METHODO
Major threats to childbirth in developing countries.: Hosp Med. 1999 Sep;60(9):633-7. Unique Identifier : AIDSLINE MED/20087668; Paruk F; Moodley J; Department of Obstetrics and Gynaecology, University of Natal; Medical School, Congella, South Africa.; Biological, psychological or social elements may constitute a threat to childbirth. In developing countries, major threats to childbirth mainly caused by restricted health service budgets may be overcome by the introduction of appropriate screening tests, implementation of evidence-based medicine protocols, and a prim
Human immunodeficiency virus and acute fulminant infection.: Hosp Med. 1999 Sep;60(9):680-1. Unique Identifier : AIDSLINE MED/20087678; Lucas DN; Gill JK; Nelson M; Soni N; Magill Department of Anaesthetics, Chelsea & Westminster; Hospital, London.
Management of occupational exposure to HIV--what actually happens.: Commun Dis Public Health. 1999 Dec;2(4):287-90. Unique Identifier : AIDSLINE MED/20066335; Sidwell RU; Green JS; Novelli V; Hospital for Sick Children, London.; A year after the Department of Health issued guidelines on post exposure prophylaxis (PEP) for health care workers exposed to HIV, we conducted a telephone survey of occupational health nurses and junior doctors in London teaching hospitals, to assess implementation of the guidelines and awareness among junior doctors
The social determinants of emergency department and hospital use by injection drug users in Canada.: J Urban Health. 1999 Dec;76(4):409-18. Unique Identifier : AIDSLINE MED/20075682; Palepu A; Strathdee SA; Hogg RS; Anis AH; Rae S; Cornelisse PG; Patrick DM; O'Shaughnessy MV; Schechter MT; Centre for Health Evaluation and Outcome Sciences, St. Paul's; Hospital, Vancouver, BC, Canada. anita@hivnet.ubc.ca; OBJECTIVE: The aim of this study was to describe the relationship between sociodemographic characteristics and human immunodeficiency (HIV) status of a cohort of injection drug users (IDUs) on their self-reported health service utilization. DESIGN: Interviewer-administered questionnaire. METHODS: IDUs who had injected
Project neighborhoods in action: an HIV-related intervention project targeting drug abusers in Washington, DC.: J Urban Health. 1999 Dec;76(4):419-34. Unique Identifier : AIDSLINE MED/20075683; Hoffman JA; Klein H; Crosby H; Clark DC; Friends Research Institute--DC, Washington, USA.; Project Neighborhoods in Action was a human immunodeficiency virus (HIV) outreach and intervention program that was conducted with injection drug users and crack users in several inner-city neighborhoods in the District of Columbia. Study participants were placed randomly in either a standard intervention or an enhanc
Self-reported legal needs of women with or at risk for HIV infection. The Her Study Group.: J Urban Health. 1999 Dec;76(4):435-47. Unique Identifier : AIDSLINE MED/20075684; Distabile P; Dubler NN; Solomon L; Klein RS; Department of Epidemiology and Social Medicine, Montefiore; Medical Center and Albert Einstein College of Medicine, Bronx,; New York, USA.; Women at risk for human immunodeficiency virus (HIV) infection are often poor and members of racial or ethnic minorities. In addition to legal concerns that might be common among persons with similar sociodemographic characteristics, HIV infection adds the potential of possible stigma and discrimination, as well as th
Needle-exchange attendance and health care utilization promote entry into detoxification.: J Urban Health. 1999 Dec;76(4):448-60. Unique Identifier : AIDSLINE MED/20075685; Strathdee SA; Celentano DD; Shah N; Lyles C; Stambolis VA; Macalino G; Nelson K; Vlahov D; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, MD 21205, USA. Sstrathd@jhsph.edu; This study was undertaken to identify factors associated with entry into detoxification among injection drug users (IDUs), and to assess the role of needle-exchange programs (NEPs) as a bridge to treatment. IDUs undergoing semiannual human immunodeficiency virus (HIV) tests and interviews were studied prospectively be
Evaluating supervised HAART in late-stage HIV among drug users: a preliminary report.: J Urban Health. 1999 Dec;76(4):468-80. Unique Identifier : AIDSLINE MED/20075687; Greenberg B; Berkman A; Thomas R; Hoos D; Finkelstein R; Astemborski J; Vlahov D; New York Academy of Medicine, Office of Special Population/Center; for Urban Epidemiologic Studies, NY 10029, USA.; bgreenberg@nyam.org; OBJECTIVE: To examine response to highly active antiretroviral therapy (HAART) among a sample of treatment-experienced patients in the late stage of human immunodeficiency virus (HIV) infection in residential health care facilities (RHCFs) in New York City facilities designated for HIV/AIDS (acquired immunodeficiency
Microsporidiosis in travelers with diarrhea from the tropics.: J Travel Med. 1999 Dec;6(4):223-7. Unique Identifier : AIDSLINE MED/20045141; Lopez-Velez R; Turrientes MC; Garron C; Montilla P; Navajas R; Fenoy S; del Aguila C; Tropical Medicine and Clinical Parasitology Unit, Infectious; Diseases-Microbiology, Hospital Ramon y Cajal, Madrid, Spain.; BACKGROUND: Microsporidia are protozoa which mainly affect severely immunodepressed AIDS patients in developed countries as well as those in developing ones. Traveler s diarrhea affects approximately 40% of people traveling from industrialized countries to developing ones, and no pathogens are identified in many of th
Preventing mother-to-child transmission of HIV in Africa [editorial; comment]: Bull World Health Organ. 1999;77(11):869-70. Unique Identifier : AIDSLINE MED/20079705; Piot P; Coll-Seck A
Reducing perinatal HIV transmission in developing countries through antenatal and delivery care, and breastfeeding: supporting infant survival by supporting women's survival [see comments]: Bull World Health Organ. 1999;77(11):871-7. Unique Identifier : AIDSLINE MED/20079706; Berer M; In 1998, a joint UNAIDS /UNICEF/WHO working group announced an initiative to pilot test an intervention to reduce perinatal transmission of human immunodeficiency virus (HIV), based on new guidelines on HIV and infant feeding. This intervention for developing countries includes shor
A pragmatic intervention to promote condom use by female sex workers in Thailand.: Unique Identifier : AIDSLINE MED/20079708; Ford N; Koetsawang S; Department of Geography, University of Exeter, England.; An overview is presented of a multifaceted intervention to promote consistent condom use by female commercial sex workers in Thailand , in the context of the government s 100% condom use policy for preventing spread of human immunodeficiency virus (HIV) infection. The project is d
Anaemia during pregnancy in Burkina Faso, west Africa, 1995-96: prevalence and associated factors. DITRAME Study Group.: Bull World Health Organ. 1999;77(11):916-22. Unique Identifier : AIDSLINE MED/20079711; Meda N; Mandelbrot L; Cartoux M; Dao B; Ouangre A; Dabis F; Centre MURAZ/Organisation de Coordination et de Cooperation pour; la lutte contre les Grandes Endemies(OCCGE), Burkina Faso.; nmeda.muraz@fasonet.bf; We report the results of a cross-sectional study carried out in 1995-96 on anaemia in pregnant women who were attending two antenatal clinics in Bobo-Dioulasso, Burkina Faso , as part of a research programme including a clinical trial of zidovudine (ZDV) in pregnancy (ANRS 049 Clin
Food and Drug Administration approval for 2 new molecular infectious disease assays [news]: Mol Diagn. 1999 Sep;4(3):256. Unique Identifier : AIDSLINE MED/20108292; Press RD
The elevated ratio of interferon gamma-/interleukin-4-positive T cells found in synovial fluid and synovial membrane of rheumatoid arthritis patients can be changed by interleukin-4 but not by interleukin-10 or transforming growth factor beta.: Rheumatology (Oxford). 1999 Nov;38(11):1058-67. Unique Identifier : AIDSLINE MED/20028152; Yin Z; Siegert S; Neure L; Grolms M; Liu L; Eggens U; Radbruch A; Braun J; Sieper J; Department of Medicine, Division of Nephrology, Klinikum Benjamin; Franklin, Free University, Berlin, Germany.; OBJECTIVES: To quantify the T-helper type (Th) 1 cytokine interferon gamma (IFN-gamma)-positive and the Th2 cytokine interleukin (IL)-4-positive cells in synovial fluid (SF) and synovial membrane (SM) at the single-cell level in rheumatoid arthritis (RA) in comparison to reactive arthritis (ReA), and to manipulate the
Simian virus 40 is present in most United States human mesotheliomas, but it is rarely present in non-Hodgkin's lymphoma.: Chest. 1999 Dec;116(6 Suppl):470S-473S. Unique Identifier : AIDSLINE MED/20084529; Rizzo P; Carbone M; Fisher SG; Matker C; Swinnen LJ; Powers A; Di Resta I; Alkan S; Pass HI; Fisher RI; Cardinal Bernardin Cancer Center, Loyola University Chicago,; Maywood, IL 60153, USA.; Simian virus 40 (SV40) causes mesotheliomas, osteosarcomas, ependymomas, choroid plexus tumors, and lymphomas in hamsters. In humans, SV40 has been detected in tumors of the first four types. Using the polymerase chain reaction (PCR), we tested 29 non-Hodgkin s lymphomas (intermediate and high-grade), 25 posttransplan
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination.: Unique Identifier : AIDSLINE MED/20031642; Quong MW; Harris DP; Swain SL; Murre C; The basic helix-loop-helix protein, E2A, is required for proper early B lymphopoiesis. Specifically, in E2A-deficient mice, B-cell development is blocked at the progenitor stage prior to the onset of immunoglobulin (Ig) V(D)J recombination. Here, we demonstrate that E2A plays an additional role during peripheral B lym
Immunology of type 1 diabetes. Intervention and prevention strategies.: Endocrinol Metab Clin North Am. 1999 Dec;28(4):841-64, x. Unique Identifier : AIDSLINE MED/20077123; Bertera S; Alexander A; Giannoukakis N; Robbins PD; Trucco M; Department of Pediatrics, University of Pittsburgh School of; Medicine, Pennsylvania, USA.; Type 1 diabetes is the outcome of a progressive and selective destruction of insulin-producing cells in the pancreatic islets of Langerhans. The precise cause and mechanism(s) that trigger the insulin-producing cell destruction are still unclear, although it is well accepted that an autoimmune process plays a central
Changing trends in cytomegalovirus retinitis with highly active anti-retroviral therapy (HAART) [editorial]: Eye. 1999 Jun;13 ( Pt 3a):275-6. Unique Identifier : AIDSLINE MED/20089545; Dhillon B; Ramaesh K; Leen C
Ocular complications of intravenous cidofovir for cytomegalovirus retinitis in patients with AIDS.: Eye. 1999 Jun;13 ( Pt 3a):353-6. Unique Identifier : AIDSLINE MED/20089558; Bainbridge JW; Raina J; Shah SM; Ainsworth J; Pinching AJ; St Bartholomew's Hospital, London, UK.; PURPOSE: To describe the frequency of anterior uveitis and ocular hypotony in cidofovir-treated patients with acquired immune deficiency syndrome (AIDS)-related cytomegalovirus ( CMV ) retinitis. METHODS: A retrospective review
A psychoeducational group intervention for HIV-positive children: a pilot study.: Health Soc Work. 1999 Nov;24(4):303-6. Unique Identifier : AIDSLINE MED/20073569; Bacha T; Pomeroy EC; Gilbert D; Pediatric AIDS Clinic, Arnold Palmer Hospital for Children and; Women, Orlando, Florida, USA.
Routine screening for HIV and hepatitis B in patients undergoing cardiac catheterisation: the need to make it mandatory.: Indian Heart J. 1999 May-Jun;51(3):285-8. Unique Identifier : AIDSLINE MED/20089193; Satish OS; Raghu C; Lakshmi V; Rao DS; Department of Cardiology, Nizam's Institute of Medical Sciences,; Hyderabad.; Reuse of catheters during cardiac catheterisation and interventions is a routine practice in our country. However, the reuse of catheters is complicated by the inherent difficulties in adequate sterilisation of these devices. Gas sterilisation with ethylene oxide has been found to be ineffective when residual fluid wa
Leishmania species: models of intracellular parasitism.: J Cell Sci. 1999 Sep;112 Pt 18:2993-3002. Unique Identifier : AIDSLINE MED/99393545; Alexander J; Satoskar AR; Russell DG; Department of Immunology, University of Strathclyde, Todd Centre,; Glasgow G4 0NR, UK. j.alexander@strath.ac.uk; Leishmania species are obligate intracellular parasites of cells of the macrophage-dendritic cell lineage. Indeed, the ability to survive and multiply within macrophages is a feature of a surprising number of infectious agents of major importance to public health, including Mycobacterium tuberculosis, Mycobacterium le
Hepatitis C virus and blood transfusion: past and present risks.: J Hepatol. 1999;31 Suppl 1:101-6. Unique Identifier : AIDSLINE MED/20086282; van der Poel CL; Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.; C_van_der_Poel@CLB.nl; The risk of HCV transmission by blood and blood products has been greatly reduced since the early 1980 s. Selection of non-remunerated donors, donor selection to prevent HIV transmission, initial surrogate testing in some regions, and introduction of anti-HCV testing have all contributed to this. ALT surrogate testing
Hepatitis C and HIV infection: biological, clinical, and therapeutic implications.: J Hepatol. 1999;31 Suppl 1:119-23. Unique Identifier : AIDSLINE MED/20086285; Soriano V; Garcia-Samaniego J; Rodriguez-Rosado R; Gonzalez J; Pedreira J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III Madrid, Spain. vsoriano@dragonet.es; As deaths from AIDS continue to decline in HIV-infected persons, liver disease is becoming an increasing cause of hospital admission and death in HIV-HCV co-infected persons. The problem is particularly relevant among intravenous drug users and haemophiliacs, most of whom are co-infected. Moreover, the risk of hepatot
Hepatitis C virus infection in children.: J Hepatol. 1999;31 Suppl 1:124-9. Unique Identifier : AIDSLINE MED/20086286; Ruiz-Moreno M; Leal-Orozco A; Millan A; Pediatrics Department - Fundacion Jimenez Diaz, Universidad; Autonoma de Madrid, Spain. rmoreno@fjd.es; The prevalence of hepatitis C virus (HCV) infection is relatively low in childhood, with anti-HCV prevalence rates of 0.1-0.4% in the Western world. To date, blood transfusion has been the principal route of acquisition of HCV in children, but there is evidence that vertical transmission is overtaking it. The overall
Treatment of naive patients with chronic hepatitis C.: J Hepatol. 1999;31 Suppl 1:168-73. Unique Identifier : AIDSLINE MED/20086293; Weiland O; Department of Immunology, Microbiology, Pathology, and Infectious; Diseases, Karolinska Institute at Huddinge Hospital, Sweden.; ola.weiland@impi.ki.se; Treatment of chronic hepatitis C virus (HCV) infection in naive patients with interferon alpha alone or in combination with ribavirin is reviewed. Two placebo-controlled randomised studies including 150 patients have shown that ribavirin as single therapy at standard dosage (15 mg/kg bodyweight in two divided doses da
Natural history of hepatitis C.: J Hepatol. 1999;31 Suppl 1:17-24. Unique Identifier : AIDSLINE MED/20086267; Alberti A; Chemello L; Benvegnu L; Department of Clinical and Experimental Medicine, University of; Padova, Italy. albertia@ux1.unipd.it; Ten years after the discovery of the hepatitis C virus (HCV) and its association with NANB hepatitis as a major cause of chronic liver disease worldwide, our knowledge of the natural history of hepatitis C is still limited. The asymptomatic course of the disease in most patients, its slow and silent progression and he
Effects of interferon therapy in "non responder" patients with chronic hepatitis C.: J Hepatol. 1999;31 Suppl 1:178-83. Unique Identifier : AIDSLINE MED/20086295; Poynard T; Moussali J; Ratziu V; Regimbeau C; Opolon P; Service d'Hepatologie, Hopital Pitie-Salpetriere, Paris,; France.; We reviewed the impact of interferon treatment on viral load, transaminase serum activity and histological features in patients with chronic hepatitis C in whom treatment did not result in a sustained virus eradication. As patients with cirrhosis are often called non responders, we also reviewed the impact of interfer
Treatment of acute hepatitis C virus infection.: J Hepatol. 1999;31 Suppl 1:189-92. Unique Identifier : AIDSLINE MED/20086297; Vogel W; Department of Gastroenterology and Hepatology, Innsbruck; University. wolfgang.vogel@uibk.ac.at; Chronic hepatitis C is the leading cause of liver-related morbidity and mortality in the Western world. Treatment response in the chronic phase of the disease is still unsatisfactory. Acute hepatitis C takes a chronic course in more than 50% of cases. Interferon therapy treatment in the acute presentation phase is, ac
Treatment of chronic hepatitis C in special groups.: J Hepatol. 1999;31 Suppl 1:205-9. Unique Identifier : AIDSLINE MED/20086301; Pol S; Zylberberg H; Fontaine H; Brechot C; Unite d'Hepatologie et INSERM U-370, Hopital Necker, Paris,; France.; Little is known about treatment of hepatitis C virus (HCV) infection in other groups than the general population, namely patients with hematologic or renal disorders and patients with human immune deficiency (HIV) co-infection. The aim was to better define HCV therapies in these groups. We analyzed the medical liter
Immunopathogenesis of hepatitis C virus infection.: J Hepatol. 1999;31 Suppl 1:31-8. Unique Identifier : AIDSLINE MED/20086269; Ferrari C; Urbani S; Penna A; Cavalli A; Valli A; Lamonaca V; Bertoni R; Boni C; Barbieri K; Uggeri J; Fiaccadori F; Laboratorio di Immunopatologia Virale, Azienda Ospedaliera di; Parma, Italy. cafer@tin.it
Mother-to-infant transmission of hepatitis C virus.: J Hepatol. 1999;31 Suppl 1:96-100. Unique Identifier : AIDSLINE MED/20086281; Zanetti AR; Tanzi E; Newell ML; Institute of Virology, University of Milan, Italy.; alessandro.zanetti@unimi.it; The rate of mother-to-infant transmission of hepatitis C virus (HCV) is approximately 5%, but is higher when the mother is co-infected with HIV Vertical transmission is restricted to infants whose mothers are viraemic. The risk of transmission increases with increasing maternal viral load but a specific cut-off value
Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers.: J Immunol. 2000 Jan 1;164(1):208-16. Unique Identifier : AIDSLINE MED/20072749; Slifka MK; Whitton JL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA. mslifka@scripps.edu; Dissecting the mechanisms of T cell-mediated immunity requires the identification of functional characteristics and surface markers that distinguish between activated and memory T lymphocytes. In this study, we compared the rates of cytokine production by virus-specific primary and memory CD8+ T cells directly ex vivo
Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: role of CD8+ T cells and IL-18.: J Immunol. 2000 Jan 1;164(1):223-30. Unique Identifier : AIDSLINE MED/20072751; Hansen G; Yeung VP; Berry G; Umetsu DT; DeKruyff RH; Division of Immunology and Transplantation Biology, Department of; Pediatrics, Stanford University, CA 94305, USA.; Asthma is a respiratory disorder characterized by airway hyperreactivity (AHR) and inflammation and is associated with high serum IgE and overproduction of IL-4, IL-5, and IL-13 by allergen-specific Th2 cells. Our previous studies demonstrated that heat-killed Listeria monocytogenes (HKL) as an adjuvant in immunothera
Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice.: J Immunol. 2000 Jan 1;164(1):240-7. Unique Identifier : AIDSLINE MED/20072753; Lepault F; Gagnerault MC; Centre National de la Recherche Scientifique, Unite Mixte de; Recherche 8603, Universite Paris V, Hopital Necker, Paris,; France. lepault@necker.fr; The period that precedes onset of insulin-dependent diabetes mellitus corresponds to an active dynamic state in which pathogenic autoreactive T cells are kept from destroying beta cells by regulatory T cells. In prediabetic nonobese diabetic (NOD) mice, CD4+ splenocytes were shown to prevent diabetes transfer in immun
Th2-dependent B cell responses in the absence of CD40-CD40 ligand interactions.: J Immunol. 2000 Jan 1;164(1):248-55. Unique Identifier : AIDSLINE MED/20072754; Chirmule N; Tazelaar J; Wilson JM; Institute for Human Gene Therapy, Department of Molecular; Engineering, University of Pennsylvania, Philadelphia 19104, USA.; CD40 is thought to play a central role in T cell-dependent humoral responses through two distinct mechanisms. CD4+ T helper cells are activated via CD40-dependent Ag presentation in which CD80/CD86 provides costimulation through CD28. In addition, engagement of CD40 on B cells provides a direct pathway for activation
Conserved MHC class I peptide binding motif between humans and rhesus macaques.: J Immunol. 2000 Jan 1;164(1):283-91. Unique Identifier : AIDSLINE MED/20072758; Dzuris JL; Sidney J; Appella E; Chesnut RW; Watkins DI; Sette A; Epimmune, San Diego, CA 92121, USA. jdzuris@epimmune.com; Since the onset of the HIV pandemic, the use of nonhuman primate models of infection has increasingly become important. An excellent model to study HIV infection and immunological responses, in particular cell-mediated immune responses, is SIV infection of rhesus macaques. CTL epitopes have been mapped using SIV-infec
Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family.: J Immunol. 2000 Jan 1;164(1):308-18. Unique Identifier : AIDSLINE GENBANK/AF084221; Korthauer U; Nagel W; Davis EM; Le Beau MM; Menon RS; Mitchell EO; Kozak CA; Kolanus W; Bluestone JA; Ben May Institute for Cancer Research, University of Chicago, IL; 60637, USA.; It has been proposed that the maintenance of T cell anergy depends on the induction of negative regulatory factors. Differential display of reverse transcribed RNA was used to identify novel genes that might mediate this function in anergic Th1 clones. We report that anergic Th1 clones do indeed express a genetic prog
Development of lupus in BXSB mice is independent of IL-4.: J Immunol. 2000 Jan 1;164(1):38-42. Unique Identifier : AIDSLINE MED/20072726; Kono DH; Balomenos D; Park MS; Theofilopoulos AN; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA. dkono@scripps.edu; Although systemic lupus erythematosus appears to be a humorally mediated disease, both Th1 and Th2 type responses have been implicated in its pathogenesis. The Th1 response, as exemplified by IFN-gamma production, has been uniformly shown in mouse lupus models to be critical for disease induction. The role of Th2 type
Differential contribution of Fas- and perforin-mediated mechanisms to the cell-mediated cytotoxic activity of naive and in vivo-primed intestinal intraepithelial lymphocytes.: Unique Identifier : AIDSLINE MED/20072771; Corazza N; Muller S; Brunner T; Kagi D; Mueller C; Intestinal intraepithelial lymphocytes (IELs) are known to exert strong constitutive cytotoxic activity. In the present study we compared the Ag-specific cytotoxic activity and the effector mechanisms involved in non-Ag-primed, naive and in in vivo-primed IELs and splenic CD8 T cells. Ex vivo isolated naive CD8alphaal
Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.: Unique Identifier : AIDSLINE MED/20072774; Juedes AE; Hjelmstrom P; Bergman CM; Neild AL; Ruddle NH; Experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 (H-2b) mice is characterized by early (day 12) acute paralysis, followed by a sustained chronic clinical course that gradually stabilizes. Extensive inflammation and demyelination coincide with clinical signs of d
Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency.: J Immunol. 2000 Jan 1;164(1):488-94. Unique Identifier : AIDSLINE MED/20072782; Cambronero R; Sewell WA; North ME; Webster AD; Farrant J; Department of Immunology, Medical Research Council; Immunodeficiency Research Group, Royal Free & University College; School of Medicine, London, United Kingdom.; We show that LPS-stimulated circulating CD14-positive monocytes from patients with common variable immunodeficiency (CVID) express a higher proportion of intracellular IL-12-positive cells than monocytes from patients with X-linked agammaglobulinemia or normal subjects. We used four-color flow cytometry and measured I
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.: J Immunol. 2000 Jan 1;164(1):512-21. Unique Identifier : AIDSLINE MED/20072785; Iwakoshi NN; Mordes JP; Markees TG; Phillips NE; Rossini AA; Greiner DL; Diabetes Division, University of Massachusetts Medical School,; Worcester 01655, USA.; A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. To study the mechanism of allograft survival, we determined the fate of tracer populations of alloreactive transgenic CD8+ T cells
Bovine and human insulin activate CD8+-autoreactive CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice.: Unique Identifier : AIDSLINE MED/20072733; Ma H; Ke Y; Li Q; Kapp JA; Department of Ophthalmology, Winship Cancer Center, Department of; Cell Biology, Emory University School of Medicine, Atlanta, GA; 30322, USA.; CD8+ T cells down-regulate a variety of immune responses. For example, porcine and human insulin do not stimulate Abs in C57BL/6 mice because CD8+ T cells inhibit CD4+ helper T cells. By contrast, bovine insulin induces Ab in C57BL/6 mice, and removal of CD8+ T cells does not alter this response. This raises the quest
AIDS-associated cryptococcal meningitis in Rwanda (1983-1992): epidemiologic and diagnostic features.: J Infect. 1999 Jul;39(1):32-7. Unique Identifier : AIDSLINE MED/99396202; Bogaerts J; Rouvroy D; Taelman H; Kagame A; Aziz MA; Swinne D; Verhaegen J; Centre Hospitalier de Kigali, Rwanda.; OBJECTIVES: to document the trend of AIDS-associated Cryptococcus neoformans meningitis (CM) in Kigali, Rwanda , during 1983-1992, and to highlight some diagnostic and epidemiological features of the disease. METHODS: during the study period, 3476 cerebrospinal fluid (CSF) specimens
High rates of disseminated infection due to non-tuberculous mycobacteria among AIDS patients in Finland.: J Infect. 1999 Jul;39(1):61-7. Unique Identifier : AIDSLINE MED/99396207; Ristola MA; von Reyn CF; Arbeit RD; Soini H; Lumio J; Ranki A; Buhler S; Waddell R; Tosteson AN; Falkinham JO 3rd; Sox CH; Department of Medicine, Helsinki University Central Hospital,; Finland.; OBJECTIVE: to determine the rate of disseminated infection due to non-tuberculous mycobacteria (NTM) among Finnish AIDS patients, and to analyse the epidemiology of these infections. METHODS: in a prospective cohort study HIV-infected patients with CD4 counts
Diagnosis of Pneumocystis carinii pneumonia: immunofluorescence staining, simple PCR or nPCR.: J Infect. 1999 Jul;39(1):77-80. Unique Identifier : AIDSLINE MED/99396209; Khan MA; Farrag N; Butcher P; Department of Medical Microbiology, St. George's Hospital Medical; School, London, UK.; OBJECTIVES: to compare immunofluorescence (IF) test, routinely used in the department for the detection of Pnemocystis carinni with simple polymerase chain reaction (PCR) and nested PCR (nPCR) METHODS: Bronchoalveolar lavage (BAL) and induced sputum (IS) specimens from HIV-positive (39), lung transplant ssart transpla
Comparison of characteristics between patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA and those with GBV-C/HGV E2-antibody in patients with hemophilia.: J Med Virol. 2000 Jan;60(1):34-8. Unique Identifier : AIDSLINE MED/20036653; Toyoda H; Takahashi I; Fukuda Y; Hayakawa T; Takamatsu J; Second Department of Internal Medicine, Nagoya University School; of Medicine, Nagoya, Japan.; We compared characteristics of patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA to those of patients with GBV-C/HGV E2-antibody. GBV-C/HGV RNA and GBV-C/HGV antibody were assayed in 83 persons with hemophilia using a reverse transcription-polymerase chain reaction and an enzyme-linked immunosorbent assay, re
False-negative HIV antibody test results.: J Med Virol. 2000 Jan;60(1):43-7. Unique Identifier : AIDSLINE MED/20036655; Preiser W; Brink NS; Hayman A; Waite J; Balfe P; Tedder RS; Department of Virology, Royal Free and University College Medical; School, University College London, Windeyer Institute of; Biomedical Science, London, United Kingdom. virology@ucl.ac.uk; Ideally HIV antibody tests have to be both extremely sensitive and able to recognize all known HIV subtypes. Three patients whose sera failed to react with a synthetic oligopeptide-based HIV antibody test are described in this report. The patients were a Pakistani male infected recently, an Australian male infected fo
Emergence of YMDD motif mutants of hepatitis B virus during lamivudine treatment of immunocompetent type B hepatitis patients.: J Med Virol. 2000 Jan;60(1):8-16. Unique Identifier : AIDSLINE MED/20036649; Seta T; Yokosuka O; Imazeki F; Tagawa M; Saisho H; First Department of Medicine, Chiba University School of; Medicine, Chiba, Japan.; Lamivudine is an effective antiviral agent for the treatment of chronic type B hepatitis. Recent studies have shown the appearance of lamivudine resistant viruses with mutations at the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the viral
The Swiss heroin trials. Scientifically sound?: J Subst Abuse Treat. 1999 Dec;17(4):331-5. Unique Identifier : AIDSLINE MED/20055247; Satel SL; Aeschbach E; Department of Psychiatry, Yale University School of Medicine, New; Haven, CT, USA. slsatel@aol.com; The objective of this article is to critique a study conducted by the Swiss Federal Office of Public Health to evaluate Switzerland s heroin maintenance project. Heroin abusers (N = 1,146) were enrolled in 18 research clinics. Subjects were recruited into three study arms--heroin, morphine, or methadone maintenance, b
The chemokine receptor antagonist AOP-RANTES reduces monocyte infiltration in experimental glomerulonephritis.: Kidney Int. 1999 Dec;56(6):2107-15. Unique Identifier : AIDSLINE MED/20063098; Panzer U; Schneider A; Wilken J; Thompson DA; Kent SB; Stahl RA; Department of Medicine, Division of Hamburg, University of; Hamburg, Germany.; The chemokine receptor antagonist AOP-RANTES reduces monocyte infiltration in experimental glomerulonephritis. BACKGROUND: This study was designed to evaluate the role of the novel chemokine receptor antagonist amino-oxypentane RANTES (AOP-RANTES), which blocks the binding of macrophage inflammatory protein-1alpha (MI
Collapsing glomerulopathy in HIV and non-HIV patients: a clinicopathological and follow-up study.: Kidney Int. 1999 Dec;56(6):2203-13. Unique Identifier : AIDSLINE MED/20063108; Laurinavicius A; Hurwitz S; Rennke HG; Department of Pathology, Brigham and Women's Hospital, Harvard; Medical School, Boston, MA, USA. alaurinavi@ip.it; Collapsing glomerulopathy in HIV and non-HIV patients: A clinicopathological and follow-up study. BACKGROUND: Collapsing glomerulopathy (CG) is a pattern of renal injury that is seen in association with HIV infection and that is increasingly recognized in non-HIV patients. METHODS: A review of native kidney biopsies w
Hemodialysis prevents liver disease caused by hepatitis C virus: role of hepatocyte growth factor.: Kidney Int. 1999 Dec;56(6):2286-91. Unique Identifier : AIDSLINE MED/20063119; Rampino T; Arbustini E; Gregorini M; Guallini P; Libetta C; Maggio M; Ranghino A; Silini E; Soccio G; Dal Canton A; Unita di Nefrologia e Dialisi and Servizio di Anatomia; Patologica, Universita ed IRCCS Ospedale San Matteo, Pavia,; Italy. dalcanton@mbox.medit.it; Hemodialysis prevents liver disease caused by hepatitis C virus: Role of hepatocyte growth factor. BACKGROUND: Hemodialysis increases markedly the serum levels of hepatocyte growth factor (HGF) so that regular dialysis treatment (RDT) mimics the regular administration of HGF as a drug. Therefore, we have studied the e
An outcome evaluation to measure changes in sexual risk-taking among gay men undergoing substance use disorder treatment.: J Stud Alcohol. 1999 Nov;60(6):837-45. Unique Identifier : AIDSLINE MED/20072513; Stall RD; Paul JP; Barrett DC; Crosby GM; Bein E; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; OBJECTIVE: To evaluate the effects of safe sex intervention at a substance use disorder treatment agency designed to serve gay men. METHOD: Of all eligible men, 456 (78%) were recruited as they entered treatment for a substance use disorder. This cohort was followed for five waves of data collection, each wave measuri
Antimicrobial prophylaxis in adults.: Mayo Clin Proc. 2000 Jan;75(1):98-109. Unique Identifier : AIDSLINE MED/20094460; Osmon DR; Division of Infectious Diseases and Internal Medicine, Mayo; Clinic Rochester, Minnesota 55905, USA.; Antimicrobial prophylaxis is used by clinicians for the prevention of numerous infections, including sexually transmitted diseases, human immunodeficiency virus infection, tuberculosis, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous
[The natural history of of the antiretrovirals: the continuum of their evaluation]: Med Clin (Barc). 1999;112 Suppl 1:59-66. Unique Identifier : AIDSLINE MED/20085521; Guerra Romero L; Stanley K; Parras Vazquez F; Plan Nacional sobre el Sida, Ministerio de Sanidad y Consumo,; Madrid. lguerra@msc.es; Antiretroviral drugs have, as any medical therapy, their natural history. They are born by screening or designing of molecules with activity against HIV, their efficacy and safety is investigated by clinical trials, evaluated by regulatory bodies, used by clinical practice, and finally analyzed by quality of care, eco
[The prevalence of human immunodeficiency virus infection and the risk behaviors in the heroin addicts of Barcelona, Madrid and Seville: an example of the advantages of centering studies on addicts and not just on intravenous users]: Med Clin (Barc). 1999 Nov 20;113(17):646-51. Unique Identifier : AIDSLINE MED/20085498; de la Fuente L; Bravo MJ; Lew C; Barrio G; Soriano V; Royuela L; Plan Nacional sobre Sida, Ministerio de Sanidad y Consumo,; Madrid. lfuente@isciii.es; BACKGROUND: The switch from intravenous heroin administration to smoking of heroin might be changed the trends in the prevalence of HIV infection and risk behaviours among Spanish users. SUBJECTS AND METHODS: Cross-sectional study of 909 regular heroin users, recruited within and outside of drug treatment centres. The
[The oxidative metabolic activity of the polymorphonuclear neutrophilic leukocytes in patients infected with the human immunodeficiency virus]: Med Clin (Barc). 1999 Nov 20;113(17):652-4. Unique Identifier : AIDSLINE MED/20085499; Diz Dios P; Ocampo Hermida A; Rayo Llerena N; Otero Varela I; Iglesias Martin I; Martinez Vazquez C; Facultad de Medicina y Odontologia, Universidad de Santiago de; Compostela, Vigo. pdiz@usc.es; BACKGROUND: Contradictory results on oxidative burst activity in HIV infection have been reported in the literature. PATIENTS AND METHODS: Neutrophil oxidative metabolism was evaluated in 160 HIV-infected patients, by measuring the intracellular production of rhodamine. RESULTS: Neutrophil oxidative metabolism was dec
[A man of 42, HIV-infected, with a rapidly evolving neurological picture (clinical conference)]: Med Clin (Barc). 1999 Nov 20;113(17):666-75. Unique Identifier : AIDSLINE MED/20085504; Pascual Calvet J; Ribalta T; Cardenal C; Servicio de Neurologia, Hospital del Mar, Barcelona.
New tools and old for management of STDs [news]: Lancet. 1999 Dec 4;354(9194):1977. Unique Identifier : AIDSLINE MED/20086021; Morris K
Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans.: Life Sci. 1999;65(24):2623-33. Unique Identifier : AIDSLINE MED/20084388; Bruunsgaard H; Jensen MS; Schjerling P; Halkjaer-Kristensen J; Ogawa K; Skinhoj P; Pedersen BK; Department of Infectious Diseases, University of Copenhagen,; Denmark. infdishb@rh.dk; This study was performed in order to investigate the type of T cells recruited to the blood in response to an acute bout of exercise with regard to mean lengths of telomeric terminal restriction fragments (TRF) and surface activation markers and with special emphasis on age-associated differences. Ten elderly and ten
In vitro transport and delivery of antisense oligonucleotides.: Unique Identifier : AIDSLINE MED/20061740; Hughes J; Astriab A; Yoo H; Alahari S; Liang E; Sergueev D; Shaw BR; Juliano RL; Department of Pharmaceutics, University of Florida, Gainesville; A variety of techniques are currently available to enhance the cellular uptake and pharmacological effectiveness of antisense oligonucleotides in the in vitro setting. The choice of technique will depend on the context of investigation, the likelihood of cytotoxity due to the delivery agents, and the ease and convenie
Niacin as a potential AIDS preventive factor.: Med Hypotheses. 1999 Nov;53(5):375-9. Unique Identifier : AIDSLINE MED/20081781; Murray MF; Tewksbury Hospital, Department of Medicine, MA 01876, USA.; docsmurr@massmed.org; A pentad of findings consistent with niacin depletion have been described in patients with AIDS. There are also clinical and laboratory data to support the potential benefit of niacin in HIV infection. In this paper, it is hypothesized that HIV infection induces niacin depletion, and that therapeutic niacin will act a
The uncoupled couple? Prolactin and CD4 lymphocytes in HIV infection.: Med Hypotheses. 1999 Nov;53(5):425-8. Unique Identifier : AIDSLINE MED/20081791; Parra A; Ramirez-Peredo J; Department of Endocrinology, Instituto Nacional de Perinatologia,; Mexico City, Mexico. parral2@hotmail.com; The possible role of prolactin (PRL) in human immunodeficiency virus (HIV) infection is unknown, despite the modulatory role of this hormone in humoral and cell-mediated immune responses. Recent studies have evidenced: (a) intralymphocyte synthesis of dopamine (DA) which down-regulates their own proliferation and diff
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.: Mol Pharmacol. 2000 Jan;57(1):116-24. Unique Identifier : AIDSLINE MED/20085433; Daelemans D; Schols D; Witvrouw M; Pannecouque C; Hatse S; van Dooren S; Hamy F; Klimkait T; de Clercq E; VanDamme AM; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Leuven, Belgium. Dirk.Daelemans@uz.kuleuven.ac.be; The peptoid CGP64222 has been previously demonstrated to inhibit the human immunodeficiency virus (HIV) Tat/transactivation response element complex formation. It has previously been shown that CGP64222 selectively inhibits HIV-1 long terminal repeat-driven gene expression and HIV-1(LAV) replication in lymphocytes. He
Painful legs and moving toes associated with neuropathy in HIV-infected patients.: Mov Disord. 1999 Nov;14(6):1053-4. Unique Identifier : AIDSLINE MED/20049388; Pitagoras de Mattos J; Oliveira M; Andre C; Department of Neurology, Hospital Universitario Clementino Fraga; Filho, Federal University of Rio de Janerio, Brazil.
The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis.: Mutat Res. 1999 Nov;437(3):231-43. Unique Identifier : AIDSLINE MED/20088946; de Martin R; Schmid JA; Hofer-Warbinek R; Department of Vascular Biology and Thrombosis Research,; University of Vienna, Vienna International Research Cooperation; Center (VIRCC), Brunnerstr. 59, A-1235, Vienna, Austria.; rainer.der.martin@univie.ac.at; Recent progress in the identification and functional analysis of protein kinases and adapter molecules that lead to activation of NF-kappaB family transcription factors has lead to a quite detailed understanding of one of the major signalling pathways that mediate a cell s response to environmental stress in a variety
[Human herpesvirus 6 A enhances HIV-1 replication in vitro by soluble mediators, this effect is diminished by endotoxin]: Orv Hetil. 1999 Nov 14;140(46):2577-80. Unique Identifier : AIDSLINE MED/20093686; Ongradi J; Ceccherini-Nelli L; Matteucci D; Bertok L; Bendinelli M; Pisai Egyetem, Orvosbiologiai Tanszek, Olaszorszag.; Simultaneous HHV-6A infection can activate HIV-1 latency and promote AIDS progression, but in this process the effects of HHV-6A induced soluble mediators on HIV-1 have not been studied yet. Recently, supernatants of HSB-2 cultures infected with HHV-6A and/or treated with endotoxin have been filtered virus free at tim
Ergotism related to a single dose of ergotamine tartrate in an AIDS patient treated with ritonavir.: Postgrad Med J. 1999 Sep;75(887):546-7. Unique Identifier : AIDSLINE MED/20084062; Blanche P; Rigolet A; Gombert B; Ginsburg C; Salmon D; Sicard D; Service de Medecine Interne 2, Hopital Cochin, Universite; Rene Descartes, Paris, France.; We report a rare case of ergotism related to a single dose of ergotamine tartrate in a man with AIDS being treated with ritonavir . He was treated with a prostacyclin analogue and made a complete recovery.
Cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.: Postgrad Med J. 1999 Oct;75(888):585-90. Unique Identifier : AIDSLINE MED/20087778; Eong KG; Beatty S; Charles SJ; Department of Ophthalmology, University of Manchester, UK.; Cytomegalovirus ( CMV ) retinitis is the most common intra-ocular infection in patients with acquired immune deficiency syndrome (AIDS), and a leading cause of AIDS-related morbidity. Untreated CMV retinitis in AIDS patients is a progressive and potentially blindi
Metal binding and activation of the ribonuclease H domain from moloney murine leukemia virus.: Protein Eng. 1999 Nov;12(11):975-80. Unique Identifier : AIDSLINE MED/20054770; Goedken ER; Marqusee S; Department of Molecular and Cell Biology, University of; California, Berkeley, 229 Stanley Hall, Berkeley, CA 94720, USA.; The RNase H family of enzymes degrades RNA in RNA.DNA hybrids in a divalent cation-dependent manner. RNases H from diverse sources such as Escherichia coli and human immunodeficiency virus (HIV) share homologous metal-binding active sites, and the activity of the RNase H domain of reverse transcriptase (RT) is require
Role of Arg163 in the N-glycosidase activity of neo-trichosanthin.: Protein Eng. 1999 Nov;12(11):999-1004. Unique Identifier : AIDSLINE MED/20054773; Li HG; Xu SZ; Wu S; Yan L; Li JH; Wong RN; Shi QL; Dong YC; Department of Protein Engineering, Institute of Biophysics,; Chinese Academy of Sciences, 15 Datun Road, Chaoyang District,; Beijing 100101 and Department of Biology, Hong Kong Baptist; University, Kowloon Tong, Hong Kong, China.; Three mutant crystals of neo-trichosanthin (n-TCS), R163K, R163H and R163Q, were obtained by the hanging drop vapor diffusion method. Structure determination indicated that there are no significant differences between the mutants and n-TCS except in the active pocket. All of them were also soaked in sodium citrate buf
Vitamin A and immunity to viral, bacterial and protozoan infections.: Proc Nutr Soc. 1999 Aug;58(3):719-27. Unique Identifier : AIDSLINE MED/20071875; Semba RD; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA. rdsemba@jhmi.edu; Studies in animal models and cell lines show that vitamin A and related retinoids play a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, natural killer cells, monocytes or macrophages, T lymphoc
Nutrition and immune function in human immunodeficiency virus infection.: Proc Nutr Soc. 1999 Aug;58(3):743-8. Unique Identifier : AIDSLINE MED/20071878; Macallan DC; Division of Infectious Diseases, St George's Hospital Medical; School, London, UK. macallan@sghms.ac.uk; The triad of human immunodeficiency virus (HIV) infection, nutritional status and immune function are intimately related, each factor having effects on the others. The dominant effect in this three-way relationship is the effect of HIV infection on nutritional status, an effect which, until the advent of potent anti-r
Induced sputum compared to bronchoalveolar lavage for evaluating patients with sarcoidosis and non-granulomatous interstitial lung disease.: Respir Med. 1999 Nov;93(11):827-34. Unique Identifier : AIDSLINE MED/20071288; Fireman E; Topilsky I; Greif J; Lerman Y; Schwarz Y; Man A; Topilsky M; Institute of Pulmonary and Allergic Diseases, Tel-Aviv Sourasky; Medical Center, Israel. fireman@fasmc.health.gov.il; Bronchoalveolar lavage (BAL), an important tool for evaluating interstitial lung diseases (ILDs), has limited utility due to its invasiveness and the difficulty of performing it in clinically contraindicated patients. We compared BAL with the induced sputum (IS) technique to analyse cells and T lymphocytes in patients
[Significance of intracranial hypertension management in cryptococcal meningitis in patients with acquired immunodeficiency syndrome. Report of 2 cases]: Unique Identifier : AIDSLINE MED/20081207; Nino Oberto S; Estanol Vidal B; Garcia Ramos G; Vega Boada F; Sierra Madero J; Two cases of cryptococcal meningitis and increased intracranial pressure in patients with acquired immunodeficiency are described. Both patients presented high intracranial pressure
HIV and aerobic exercise. Current recommendations.: Sports Med. 1999 Dec;28(6):389-95. Unique Identifier : AIDSLINE MED/20089108; Stringer WW; UCLA School of Medicine, USA. wstringer@email.msn.com; Aerobic exercise training is an important therapy to offer individuals who are HIV positive (HIV+). Six to 12 weeks of moderate exercise sessions (3 times per week for 1 hour) significantly improves aerobic capacity (VO2max and lactic acidosis threshold), apparently without detrimental effects on the immune system. In
[Tuberculosis manifestations in the musculoskeletal system exemplified by Poncet's disease]: Schweiz Med Wochenschr. 1999 Nov 27;129(47):1839-42. Unique Identifier : AIDSLINE MED/20077286; Kowalski M; Seitz M; Klinik fur Rheumatologie und klinische Immunologie/Allergologie,; Universitat Bern.; Tuberculosis is a communicable disease that is occasionally complicated by arthritis, either as part of a disseminated primary infection or through late reactivation, often in immunocompromised hosts such as elderly people, HIV-positive patients or patients under immunosuppressive therapy. Even though musculoskeletal
CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice.: Transplantation. 1999 Dec 27;68(12):1891-7. Unique Identifier : AIDSLINE MED/20092351; Gao Q; Rouse TM; Kazmerzak K; Field EH; Department of Internal Medicine, University of Iowa College of; Medicine, Iowa City 52242, USA.; BACKGROUND: Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. Anergic CD8 T cells are present in tolerant mice, and CD4 r
Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.: Transplantation. 1999 Dec 27;68(12):1912-4. Unique Identifier : AIDSLINE MED/20092355; Peters MG; Singer G; Howard T; Jacobsmeyer S; Xiong X; Gibbs CS; Lamy P; Murray A; University of California at San Francisco, 94143, USA.; mpeters@itsa.ucsf.edu; BACKGROUND: Mutations in the hepatitis B virus (HBV) genome may occur during therapy. METHODS: We report an asymptomatic HBV carrier who underwent transplantation for end-stage renal disease. She developed an HBV flare 6 months after transplantation and was placed on lamivudine. After initial rapid improvement, she re
[Nosocomial HIV transmission at a Danish hospital department]: Ugeskr Laeger. 1999 Nov 15;161(46):6364-5. Unique Identifier : AIDSLINE MED/20077962; Katzenstein TL; Nielsen C; Gerstoft J
Vaccination and HIV: a review of the literature.: Vaccine. 1999 Dec 10;18(9-10):825-31. Unique Identifier : AIDSLINE MED/20048106; Rousseau MC; Moreau J; Delmont J; Department of Infectious Diseases, Center for training and; research in Tropical Medicine, University Hospital; Houphouet-Boigny, 415 Chemin de la Madrague Ville 13015,; Marseille, France.; People with HIV are at risk for a variety of infections both at home and abroad. Recent studies have reported conflicting data concerning potential harmful effects following several inactivated vaccines. Antigenic stimulation by vaccines designed to prevent secondary infections may promote HIV-1 replication in certain
Vaccine-induced cytotoxic T lymphocytes against human immunodeficiency virus type 1 using two complementary in vitro stimulation strategies.: Vaccine. 1999 Dec 10;18(9-10):835-49. Unique Identifier : AIDSLINE MED/20048108; Gorse GJ; Patel GB; Mandava MD; Belshe RB; St. Louis Department of Veterans Affairs Medical Center, St.; Louis, MO, USA. gorsegj@slu.edu; CD8+ cytotoxic T lymphocytes (CTL) against human immunodeficiency virus type 1 (HIV-1) induced by candidate HIV-1 vaccines may be a mechanism of immune protection against HIV-1 infection. We measured in vitro inducible CD8+ and CD4+ CTL using two in vitro effector cell stimulation strategies. Peripheral blood mononucl
4th European HTLV Pathogenesis Meeting. Paris, France, 8 June 1999. Abstracts.: Virus Res. 1999 Dec 1;65(1):1-10. Unique Identifier : AIDSLINE MED/20108294
Progressive multifocal leukoencephalopathy in AIDS: are there any MR findings useful to patient management and predictive of patient survival? AIDS Clinical Trials Group, 243 Team.: AJNR Am J Neuroradiol. 1999 Nov-Dec;20(10):1896-906. Unique Identifier : AIDSLINE MED/20053337; Post MJ; Yiannoutsos C; Simpson D; Booss J; Clifford DB; Cohen B; McArthur JC; Hall CD; Department of Radiology, University of Miami School of Medicine,; MRI Center, FL 33136, USA.; BACKGROUND AND PURPOSE: While MR findings in progressive multifocal leukoencephalopathy (PML) have been described previously, usually in retrospective studies with limited sample size, what has not been well addressed is whether any are predictive of longer survival. Our participation in a large prospective clinical t
Is the prevalence of HIV-associated nephropathy decreasing?: Unique Identifier : AIDSLINE MED/20080689; Ahuja TS; Borucki M; Funtanilla M; Shahinian V; Hollander M; Rajaraman S; Initial reports have suggested that approximately 10% of patients with HIV-infection develop HIV-associated nephropathy (HIVAN). It has also been predicted that by the end of the decade, HIVAN is likely to become a third leading cause of end-stage renal disease (ESRD) in African-Americans between the ages of 20-64 yea
Outcome of an opportunistic infection after polymicrobial peritonitis in an HIV-infected patient treated with peritoneal dialysis.: Unique Identifier : AIDSLINE MED/20080694; Varela MP; Lew SQ; Smith AM; Whyte RL; Bosch JP; Division of Renal Diseases & Hypertension, Department of; Medicine, The George Washington University Medical Center,; Washington, DC 20037, USA.; The prevalence of human immuodeficiency virus (HIV)-infected patients with end stage renal disease (ESRD) is likely to increase and many of them will be on peritoneal dialysis as renal replacement therapy. Infectious complications are a major problem associated with peritoneal dialysis (PD). It has been speculated tha
Effects of human immunodeficiency virus 1 infection on microbial origins of pelvic inflammatory disease and on efficacy of ambulatory oral therapy.: Am J Obstet Gynecol. 1999 Dec;181(6):1374-81. Unique Identifier : AIDSLINE MED/20068419; Bukusi EA; Cohen CR; Stevens CE; Sinei S; Reilly M; Grieco V; Eschenbach DA; Holmes KK; Bwayo J; Ndinya-Achola JO; Kreiss J; Center for Microbiology Research, Kenya Medical Research; Institute, University of Nairobi.; OBJECTIVE: This study was undertaken to determine the effects of human immunodeficiency virus 1 infection on the clinical presentation, severity, causal organisms, and response to ambulatory therapy of pelvic inflammatory disease. STUDY DESIGN: Women 18 to 40 years old with lower abdominal pain for
Positive cone biopsy specimen margins in women infected with the human immunodeficiency virus.: Am J Obstet Gynecol. 1999 Dec;181(6):1395-9. Unique Identifier : AIDSLINE MED/20068423; Boardman LA; Peipert JF; Hogan JW; Cooper AS; Department of Obstetrics and Gynecology, Women and Infants'; Hospital of Rhode Island, Providence 02905, USA.; OBJECTIVES: The purpose of this study was to compare the positive margin rate associated with cervical conization among women who are seropositive for human immunodeficiency virus with that among women who are seronegative. STUDY DESIGN: This was a cross-sectional study of 245 women who underwent cervical conization f
Living and dying with HIV/AIDS: A psychosocial perspective [clinical conference]: Am J Psychiatry. 2000 Jan;157(1):110-3. Unique Identifier : AIDSLINE MED/20084825; Ruiz P; Department of Psychiatry and Behavioral Sciences, University of; Texas Medical School at Houston, 77030, USA.; pruiz@msi.uth.tmc.edu
Erythema elevatum diutinum in an HIV+ hemophilic patient [letter]: Am J Dermatopathol. 1999 Dec;21(6):587-8. Unique Identifier : AIDSLINE MED/20073936; Sanz-Trelles A; Ayala-Carbonero A; Ojeda-Martos A
Inhibition of HIV-1 infection by zinc group metal compounds.: Antiviral Res. 1999 Sep;43(2):123-33. Unique Identifier : AIDSLINE MED/99444902; Haraguchi Y; Sakurai H; Hussain S; Anner BM; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Maebashi, Japan.; Thirty-seven metal compounds were examined for inhibitory activities against infection with human immunodeficiency virus type 1 (HIV-1). Zinc group metal compounds, namely, zinc acetate, zinc chloride, zinc nitrate, cadmium acetate and mercury chloride, showed anti-HIV-1 activities. Cadmium and mercury compounds at 1-
Isolation and partial characterization of an antiviral, RC-183, from the edible mushroom Rozites caperata.: Antiviral Res. 1999 Sep;43(2):67-78. Unique Identifier : AIDSLINE MED/99444897; Piraino F; Brandt CR; Department of Ophthalmology and Visual Sciences, University of; Wisconsin Medical School, Madison 53706-1532, USA.; A protein of 10,425 Da was purified from the edible mushroom Rozites caperata and shown to inhibit herpes simplex virus types 1 and 2 replication with an IC50 value of
Immunomodulation by thalidomide and thalidomide analogues.: Ann Rheum Dis. 1999 Nov;58 Suppl 1:I107-13. Unique Identifier : AIDSLINE MED/20046943; Corral LG; Kaplan G; Celgene Corporation, Warren, NJ, USA.
Tumour necrosis factor and other cytokines in murine lupus.: Ann Rheum Dis. 1999 Nov;58 Suppl 1:I49-55. Unique Identifier : AIDSLINE MED/20046930; Theofilopoulos AN; Lawson BR; Department of Immunology, The Scripps Research Institute, La; Jolla, USA.
Retroviruses in autoimmune liver disease: genetic or environmental agents?: Arch Immunol Ther Exp (Warsz). 1999;47(5):289-97. Unique Identifier : AIDSLINE MED/20067723; Mason AL; Xu L; Guo L; Garry RF; Section of Gastroenterology and Hepatology, Alton Ochsner Medical; Foundation, New Orleans, LA 70121, USA.; Retroviruses have been implicated in the pathogenesis of several human autoimmune conditions including Sjogren s syndrome, primary biliary cirrhosis, immune mediated diabetes, and multiple sclerosis. The human intracisternal A type particle derived from Sjogren s syndrome patients salivary glands was the first retrov
Cage dimeric N-acyl- and N-acyloxy-4-aryl-1,4-dihydropyridines as first representatives of a novel class of HIV-1 protease inhibitors.: Arch Pharm (Weinheim). 1999 Nov;332(11):380-4. Unique Identifier : AIDSLINE MED/20073304; Hilgeroth A; Billich A; Institut fur Pharmazeutische Chemie der; Martin-Luther-Universitat Halle-Wittenberg, Germany.; The synthesis of a series of novel cage dimeric N-acyl and N-acyloxy-4-aryl-1,4-dihydropyridines starting either from solid-state synthetic ester dimers or from monomeric 4-aryl-1,4-dihydropyridines is presented. Their biological evaluation as novel HIV-1 protease inhib
Full-thickness skin grafting of eyelids in a patient with generalized morphea taking thalidomide.: Arch Ophthalmol. 2000 Jan;118(1):135-6. Unique Identifier : AIDSLINE MED/20100389; Periman LM; Sires BS; University of Washington, Ophthalmology, Seattle 98195-6485, USA.
Effectiveness of a single and a repeated screen for hearing loss in the elderly.: Audiology. 1999 Nov-Dec;38(6):339-40. Unique Identifier : AIDSLINE MED/20047361; van den Berg PJ; Prins A; Verschuure H; Hoes AW; Department of General Practice, Erasmus University Rotterdam, The; Netherlands.; The aim of this study was to assess the value of repeated audiometric screens offered to elderly in general practice. In 1991, an audiometric screen was performed on 660 participants, aged 60 years and over, enlisted in one general practice near Rotterdam, the Netherlands . We
Lysozyme association with nucleic acids.: Biochem Biophys Res Commun. 1999 Dec 20;266(2):366-70. Unique Identifier : AIDSLINE MED/20068772; Steinrauf LK; Shiuan D; Yang WJ; Chiang MY; Departments of Biological Science and Chemistry, National Sun; Yat-sen University, 70 Lien-hai Road, Kaohsiung, 80424, Republic; of China. lsteinra@mail.nsysu.edu.tw; Lysozyme is well known for the ability to hydrolyze the cell wall of bacteria. Based on the similarity of structure between lysozyme and histones as seen from the results of X-ray crystal structure determinations, we have postulated that binding to nucleic acids may be another biological function of lysozyme. We have
Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos.: Anticancer Drug Des. 1999 Aug;14(4):355-65. Unique Identifier : AIDSLINE MED/20091373; Izbicka E; Nishioka D; Marcell V; Raymond E; Davidson KK; Lawrence RA; Wheelhouse RT; Hurley LH; Wu RS; Von Hoff DD; Institute for Drug Development, Cancer Therapy and Research; Center, San Antonio, TX 78229, USA. eizbicka@saci.org; Cationic porphyrins, which interact with guanine quadruplex (G4) telomeric folds, inhibit telomerase activity in human tumor cells. In this study, we have further examined effects of porphyrins and other telomere- and telomerase-interactive agents on proliferation rates and chromosome stability in a novel in vivo mode
Epidemiology of HIV infection in the Republic of Korea.: J Korean Med Sci. 1999 Oct;14(5):469-74. Unique Identifier : AIDSLINE MED/20041559; Oh MD; Choe K; Department of Internal Medicine, Seoul National University; College of Medicine, Seoul National University Hospital, Korea.; Since the first case of human immunodeficiency virus (HIV) infection in the Republic of Korea (ROK) was detected in 1985, 876 HIV-infected patients have been reported, as of December 1998. The male to female ratio was 6.8:1, and 87% of the patients were between 20 and 49 years of age. The major modes of transmission w
Survival improvement with combined radio-chemotherapy in the primary central nervous system lymphomas.: J Korean Med Sci. 1999 Oct;14(5):565-70. Unique Identifier : AIDSLINE MED/20041573; Wu HG; Kim IH; Ha SW; Park CI; Bang YJ; Huh DS; Department of Therapeutic Radiology, Seoul National University; College of Medicine, Korea.; The benefits of radio-chemotherapy in HIV-negative primary central nervous system (CNS) lymphomas were analyzed in 40 patients, who received radiotherapy to the brain or craniospinal axis with the total dose of 4460-5940 cGy to the primary tumor. Radiotherapy was followed by systemic chemotherapy, mainly with the cycl
Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART.: AIDS. 1999 Dec 3;13(17):F109-14. Unique Identifier : AIDSLINE MED/20064641; Aandahl EM; Aukrust P; Muller F; Hansson V; Tasken K; Froland SS; Institute of Medical Biochemistry, University of Oslo, Norway.; OBJECTIVE: To explore the basis for a possible immunomodulatory combination therapy with IL-2 and agents inhibiting protein kinase A (PKA) type I. DESIGN: Highly active antiretroviral therapy (HAART) has dramatically im
Severe hepatic cytolysis: incidence and risk factors in patients treated by antiretroviral combinations. Aquitaine Cohort, France, 1996-1998. Groupe dEpidemiologie Clinique de Sida en Aquitaine (GECSA).: Unique Identifier : AIDSLINE MED/20064642; Saves M; Vandentorren S; Daucourt V; Marimoutou C; Dupon M; Couzigou P; Bernard N; Mercie P; Dabis F; OBJECTIVE: To study hepatic cytolysis in patients treated by highly active antiretroviral therapy (HAART) with protease inhibitor or with two nucleoside reverse transcriptase inhibitors (NRTIs). METHODS: We selected patients of the Aquitaine Cohort who initiated HAART or two NRTIs before 1 January 1998, had alanine am
Promoting early HIV diagnosis and entry into care [editorial]: AIDS. 1999 Dec 3;13(17):2317-30. Unique Identifier : AIDSLINE MED/20064643; Valdiserri RO; Holtgrave DR; West GR
Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.: AIDS. 1999 Dec 3;13(17):2331-41. Unique Identifier : AIDSLINE MED/20064644; Kohleisen B; Shumay E; Sutter G; Foerster R; Brack-Werner R; Nuesse M; Erfle V; GSF-National Research Center for Environment and Health,; Institute of Molecular Virology, Neuherberg, Germany.; OBJECTIVE: Nef was shown to be the predominant viral protein expressed in HIV-1-infected astrocytes in vivo and in vitro suggesting a distinct role of Nef in this cell type. Nef-induced activation of T cells is well described, whereas the functional activities of Nef in astrocytes are unknown. Our aim was to examine t
Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice.: AIDS. 1999 Dec 3;13(17):2343-8. Unique Identifier : AIDSLINE MED/20064645; Toneatto S; Finco O; van der Putten H; Abrignani S; Annunziata P; Institute of Neurological Sciences, University of Siena, Italy.; OBJECTIVE: To verify whether HIV envelope protein gp120 changes the blood-brain barrier in vivo, as a fundamental mechanism of early central nervous system damage by HIV-1. DESIGN: Analysis of the functional integrity and immune activation of the blood-brain barrier in brains of HIV-1 gp120 transgenic mice secreting c
Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy.: AIDS. 1999 Dec 3;13(17):2349-59. Unique Identifier : AIDSLINE MED/20064646; Nijhuis M; Schuurman R; de Jong D; Erickson J; Gustchina E; Albert J; Schipper P; Gulnik S; Boucher CA; Eijkman-Winkler Institute, Department of Virology, University; Hospital Utrecht, The Netherlands.; OBJECTIVE: It is thought as a consequence of continuous replication, HIV-1 has acquired an optimal fitness state and that suboptimal antiretroviral therapy selects for drug resistant variants which show impaired fitness in the absence of the drug. In this paper we studied the evolution and fitness of viral populations
Do gender differences in CD4 cell counts matter?: AIDS. 1999 Dec 3;13(17):2361-4. Unique Identifier : AIDSLINE MED/20064647; Prins M; Robertson JR; Brettle RP; Aguado IH; Broers B; Boufassa F; Goldberg DJ; Zangerle R; Coutinho RA; van den Hoek A; Municipal Health Service, Division of Public Health and; Environment, Amsterdam, The Netherlands.; OBJECTIVE: To examine the effect of gender on disease progression and whether gender differences in CD4 lymphocyte counts persisted for the entire course from HIV seroconversion until (death from) AIDS. METHODS: CD4 lymphocyte counts were modelled in 221 female and 443 male seroconverters following seroconversion, bac
Activation of CD8 T cells normalizes and correlates with the level of infectious provirus in tonsils during highly active antiretroviral therapy in early HIV-1 infection.: AIDS. 1999 Dec 3;13(17):2365-76. Unique Identifier : AIDSLINE MED/20064648; Dyrhol-Riise AM; Voltersvik P; Olofsson J; Asjo B; Department of Microbiology and Immunology, Centre for Research in; Virology, University of Bergen, Norway.; OBJECTIVES: To study the effects of antiretroviral therapy on T cell activation in blood and tonsils from HIV-1 infected individuals in relation to CD4 cell count, plasma viremia, and infectious HIV-1 provirus. DESIGN: A 48-week study of viral load and T cell subsets in blood and tonsils from 12 HIV-1-positive individ
A randomized study comparing triple versus double antiretroviral therapy or no treatment in HIV-1-infected patients in very early stage disease: the Spanish Earth-1 study.: AIDS. 1999 Dec 3;13(17):2377-88. Unique Identifier : AIDSLINE MED/20064649; Garcia F; Romeu J; Grau I; Sambeat MA; Dalmau D; Knobel H; Gomez-Sirvent JL; Arrizabalaga J; Cruceta A; Clotet BG; Podzamczer D; Pumarola T; Gallart T; O'Brien WA; Miro JM; Gatell JM; Institut d'Investigacions Biomediques August Pi I Sunyer,; Faculty of Medicine, University of Barcelona, Spain.; BACKGROUND: Most current guidelines state that antiretroviral therapy should be considered for HIV-infected patients with plasma HIV RNA > 5000-10000 copies/ml and CD4 cells > 500 x 10(6) cells/l. However, there is increasing concern about whether this is the optimal point to begin treatment or whether it is better to
Beneficial effects of protease inhibitors on body composition and energy expenditure: a comparison between HIV-infected and AIDS patients.: AIDS. 1999 Dec 3;13(17):2389-96. Unique Identifier : AIDSLINE MED/20064650; Pernerstorfer-Schoen H; Schindler K; Parschalk B; Schindl A; Thoeny-Lampert S; Wunderer K; Elmadfa I; Tschachler E; Jilma B; Department of Dermatology, University of Vienna Medical School,; Vienna General Hospital, Austria.; heidemarie.pernerstorfer-schoen@univie.ac.at; OBJECTIVES: (i) To investigate whether protease inhibitor (PI) (nelfinavir)-containing highly active antiretroviral therapy (HAART) affects body composition differently in HIV-infected and AIDS patients without wasting syndrome. (ii) To delineate the changes in resting energy expenditure (REE) under PI therapy, and to
A randomized, controlled, safety study using imiquimod for the topical treatment of anogenital warts in HIV-infected patients. Imiquimod Study Group.: AIDS. 1999 Dec 3;13(17):2397-404. Unique Identifier : AIDSLINE MED/20064651; Gilson RJ; Shupack JL; Friedman-Kien AE; Conant MA; Weber JN; Nayagam AT; Swann RV; Pietig DC; Smith MH; Owens ML; Department of Sexually Transmitted Diseases, Royal Free and; University College Medical School, London, UK.; OBJECTIVE: To assess the safety of imiquimod, an immune response modifier, in the topical treatment of external anogenital warts in HIV-infected patients. SETTING: Clinical sites in the United Kingdom (eight) and the United States (five). DESIGN: A pros
Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy.: AIDS. 1999 Dec 3;13(17):2405-10. Unique Identifier : AIDSLINE MED/20064652; Prins JM; Jurriaans S; van Praag RM; Blaak H; van Rij R; Schellekens PT; ten Berge IJ; Yong SL; Fox CH; Roos MT; de Wolf F; Goudsmit J; Schuitemaker H; Lange JM; Department of Internal Medicine, Tropical Medicine, and AIDS,; Academic Medical Center, University of Amsterdam, The; Netherlands. j.m.prins@amc.uva.nl; BACKGROUND