2000

Ophthalmoplegia associated with the anti-Ri antibody.: J Neuroophthalmol. 1999 Dec;19(4):246-8. Unique Identifier : AIDSLINE MED/20074390; Ohmer R; Golnik KC; Richards AI; Kosmorsky GS; Cincinnati Eye Institute, Ohio, USA.; Anti-Ri antibodies most often occur in patients with breast cancer and typically are associated with the paraneoplastic syndrome of opsoclonus-myoclonus-ataxia. This study reports a patient with diplopia and ophthalmoplegia. She had anti-Ri antibodies, and despite an exhaustive search for malignancy at presentation, b
A dosimetric comparison of fan-beam intensity modulated radiotherapy with Gamma Knife stereotactic radiosurgery for treating intermediate intracranial lesions.: Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1325-30. Unique Identifier : AIDSLINE MED/20078490; Ma L; Xia P; Verhey LJ; Boyer AL; Department of Radiation Oncology, University of Maryland School; of Medicine, Baltimore 21201, USA. lma001@umaryland.edu; PURPOSE: To compare and evaluate treatment plans for the fan-beam intensity modulated radiotherapy and the Gamma Knife radiosurgery for treating medium-size intracranial lesions (range 4-25 cm3). METHODS AND MATERIALS: Treatment plans were developed for the Leksell Gamma Knife and a fan-beam inverse treatment planning
And will we ever cure AIDS? [news]: Time. 1999 Nov 8;154(19):84. Unique Identifier : AIDSLINE AHA/20078392; Ho D
Evaluation of HIV risk reduction intervention programs via latent growth model.: Eval Rev. 1999 Dec;23(6):648-62. Unique Identifier : AIDSLINE HTA/20058223; Wang J; Siegal HA; Falck RS; Carlson RG; Rahman A; Wright State University, USA.; The latent growth model (LGM) has drawn increasing attention in behavioral studies using longitudinal data. The LGM captures the level and trajectory of behavior change, variation in both the initial status and the trend of behavior change, as well as the time-ordered covariation between the initial status and change.
Ocular manifestations of HIV infection.: Curr Opin Ophthalmol. 1999 Dec;10(6):431-7. Unique Identifier : AIDSLINE HTA/20064414; Robinson MR; Ross ML; Whitcup SM; National Institutes of Health, National Eye Institute, Bethesda,; Maryland 20892-1863, USA. mrobin@Box-m.nih.gov; Ophthalmic abnormalities are common in HIV-infected patients. Serious ophthalmic diseases often result from opportunistic infections and can cause blindness in the absence of prompt diagnosis and therapy. We review recent advances in the diagnosis and management of HIV-associated ocular disease, including
Courage as a process of pushing beyond the struggle.: Qual Health Res. 1999 Nov;9(6):803-14. Unique Identifier : AIDSLINE HTA/20038784; Finfgeld DL; Sinclair School of Nursing, University of Missouri-Columbia, USA.; Six qualitative studies have been carried out to better understand courage among individuals who range in age from 14 to 94 years and are experiencing a variety of lingering threats to their well-being. The purpose of this meta-interpretation was to synthesize those works and further delineate an emergent formal theor
Social aspects of AIDS-related stigma in rural Uganda.: Health Place. 1997 Sep;3(3):143-7. Unique Identifier : AIDSLINE HTA/20038688; Muyinda H; Seeley J; Pickering H; Barton T; MRC/ODA Research Programme on AIDS in Uganda/Uganda Virus; Research Institute UVRI, Uganda.; In the process of collecting sexual behaviour data through in-depth interviews, 24 respondents offered information on stigma related to HIV-1 infection. Observations of social relations in public places and families of infected individuals were made. The findings suggest that although HIV/AIDS-related stigma has had a
Stigmatization, HIV/AIDS, and communities of color: exploring response to human service facilities.: Health Place. 1997 Sep;3(3):187-99. Unique Identifier : AIDSLINE HTA/20038693; Takahashi LM; Department of Urban and Regional Planning, School of Social; Ecology, University of California, Irvine 92697-7075, USA.; HIV and AIDS are rapidly becoming leading causes of death for men and women in large cities across the US. Epidemiological data indicate that persons of color in particular have been disproportionately affected by HIV/AIDS. The continuing growth in the incidence of HIV/AIDS among persons of color implies that human se
Cattle markets and local festivals: development of HIV/AIDS prevention interventions for specific risk situations in rural northeast Thailand.: Health Place. 1998 Sep;4(3):265-72. Unique Identifier : AIDSLINE HTA/20038726; Dole LR; Elkins DB; Boonjear K; Phiensrithom S; Maticka-Tyndale E; Multi-sectoral AIDS Prevention Strategy (MAPS), Northeast Centre; for AIDS Prevention and Care, Khon Kaen University, Thailand.; In rural Northeast Thailand , risk of sexual transmission of HIV is popularly perceived to be site-specific. Risk of HIV transmission in local scenarios like cattle markets and village festivals has not been adequately addressed. This paper assesses the use of community consultati
Health economics. Perfect combination.: Health Serv J. 1999 Oct 7;109(5675):26-7. Unique Identifier : AIDSLINE AHA/20064496; Youle M; Weston R; Trueman P; Swaden L; Leake H; Royal Free Hampstead Trust.; The assumption by some HAs that a shift from mono to combination drug therapies for HIV results in a proportional increase in drug expenditure, regardless of health gains, is misguided. Methods of calculating anti-HIV drug expenditure have failed to keep up with changing treatment regimes. There is an urgent need to c
Health status of Asian Americans: United States, 1992-94.: Adv Data. 1998 Aug 7;(298):1-16. Unique Identifier : AIDSLINE AHA/20064472; Kuo J; Porter K; OBJECTIVES: This report compares the health status of selected Asian national origin groups. METHODS: 1992-94 National Health Interview Survey (NHIS) data were analyzed for six Asian national origin groups (Chinese, Filipino, Asian Indian, Japanese, Vietnamese, and Korean), the Asian and Pacific Islander (API) populat
Paying for HIV/AIDS care at the turn of the century.: Am J Manag Care. 1999 Nov;5(11):1442. Unique Identifier : AIDSLINE AHA/20093894; O'Neill JF; HIV/AIDS Bureau, Health Resources and Services Administration, US; Department of Health and Human Services, Washington, DC, USA.
Developing a managed care delivery system for people with HIV/AIDS.: Am J Manag Care. 1999 Nov;5(11):1443-7. Unique Identifier : AIDSLINE AHA/20093895; Singer B; Gamliel S; Conviser R; Special Projects of National Significance Program, Office of; Science and Epidemiology, HIV/AIDS Bureau, US Department of; Health and Human Services, Washington, DC, USA.; Capitated managed care is now a significant part of the healthcare landscape in the United States . Consequently, states across the country are looking to it as a means of lowering their costs for Medicaid recipients. Implementing Medicaid managed care plans, however, requires considera
Comprehensive HIV services under a capitated reimbursement system: AIDS Healthcare Foundation.: Am J Manag Care. 1999 Nov;5(11):1450-6. Unique Identifier : AIDSLINE AHA/20093896; Reis PD; AIDS Healthcare Foundation, Los Angeles, CA 90028, USA.; The application of capitated managed care systems to Medicaid populations has increased as part of an effort to control healthcare costs. The difficulties of caring for people with HIV and AIDS in the Medicaid population is compounded by the issues of impoverishment and access to care. In this profile, we discuss the
Developing a managed care delivery system in New York State for Medicaid recipients with HIV.: Unique Identifier : AIDSLINE AHA/20093897; Feldman I; Cruz H; DeLorenzo J; Hidalgo J; Plavin H; Whitaker J; In the state of New York, models of care known as HIV Special Needs Plans (HIV SNPs) are being developed to meet the unique health and medical needs of Medicaid recipients with HIV.
Will drug resistance testing prove reliable enough to enhance HIV treatments?: Fac Notes. 1998 Nov-Dec;10(6):1-3. Unique Identifier : AIDSLINE AIDS/20700001; Murphy MJ; Drug resistance testing is important in evaluating and determining the effectiveness of HIV treatments. Genotypic tests evaluate genetic segments of the virus which correspond to resistance in particular drugs. Phenotypic tests assess the level of drugs needed to stop viral growth. The advantages and disadvantages of
Anti-discrimination laws protect both patients and HCWs.: Fac Notes. 1998 Nov-Dec;10(6):4-5. Unique Identifier : AIDSLINE AIDS/20700002; Murphy G; Murphy and McKnight, LLC, New Orleans.; Most courts have interpreted the Americans with Disabilities Act to include health care workers (HCWs) and others with HIV and AIDS as having a life impairment. Therefore, the Act protects these people from discrimination in the work place or from their medical care provider. Some job activities of HIV-positive employ
LaCARP seeks patients for study that will compare protease inhibitors.: Fac Notes. 1998 Nov-Dec;10(6):6. Unique Identifier : AIDSLINE AIDS/20700003; The Louisiana Community AIDS Research Program (LaCARP) is conducting a Protease Inhibitor Progression (PIP) study to determine how to lower the amount of HIV virus in the body. The trial is for HIV-positive patients, over 13 years of age, who have detectable viral loads, and who are on their initial course of protease
Patients sought for ACTU studies that will help answer questions about drugs.: Fac Notes. 1998 Nov-Dec;10(6):6. Unique Identifier : AIDSLINE AIDS/20700004; Two trials are being conducted by the Tulane-LSU Adult AIDS Clinical Trials Unit. ACTG 384 is for patients who have not had previous antiretroviral therapy. Study objectives address when to use protease inhibitor (PI) therapy, comparisons between different drug combinations, and long-term treatment. ACTG 398 is for pe
HOP wins 3-year grant to develop palliative care program.: Fac Notes. 1998 Nov-Dec;10(6):7-8. Unique Identifier : AIDSLINE AIDS/20700005; Kutzen H; Bennett M; Medical Center of Louisiana at New Orleans, HIV Outpatient; Program.; A grant from the Robert Wood Johnson Foundation to the HIV Outpatient Program of the Medical Center of Louisiana (HOP) will establish PalCare, a program to assist people with advanced HIV/AIDS by supplying palliative care services. Palliative care bridges the gap between traditional medical responses and hospice care
Case illustrates social work philosophy in a practical setting.: Fac Notes. 1998 Nov-Dec;10(6):9-10. Unique Identifier : AIDSLINE AIDS/20700006; Rankin D; Medical Center of Louisiana at New Orleans, HIV Outpatient; Program.; A case of an unemployed, addiction-prone, homeless man with HIV is profiled by a social worker. Discussing the man s circumstances enabled the man to explore issues about his treatment, including his ability to sustain a treatment regimen. Key issues of adherence to treatment, drug use, and confidentiality were consid
Now approved: Sustiva in combination offers patients a new first-line therapy.: Fac Notes. 1998 Nov-Dec;10(6):10. Unique Identifier : AIDSLINE AIDS/20700007; DuPont Pharmaceuticals Sustiva ( efavirenz ) was approved by the FDA as the first once-daily- dosing anti-HIV drug. Sustiva is a non-nucleoside revers
When caregivers can't agree on patient's competence.: Fac Notes. 1998 Nov-Dec;10(6):11-2. Unique Identifier : AIDSLINE AIDS/20700008; Dralle PW; LSU School of Medicine, Department of Psychiatry.; The issue of whether a specific patient is capable of making decisions regarding medical treatment is discussed. A psychiatrist deemed the patient incapable of making such decisions, however, an attending physician found the patient alert and agreed to honor a request for declining treatment and returning home. Such d
Understanding the reverse transcriptase inhibitors in HIV.: Fac Notes. 1998 Nov-Dec;10(6):13-5. Unique Identifier : AIDSLINE AIDS/20700009; Edmonds-Ogbuokiri J; Xavier University College of Pharmacy, Clinical Pharmacy.; Recent progress in treatment methods and medicines has made HIV more manageable. Factors contributing to this progress include advances in testing; the use and approval of protease inhibitors , non-nucleoside reverse transcriptase inhibitors, and other nucleosides; a
Ziagen (abacavir) approved: caution essential.: AIDS Treat News. 1999 Jan 8;(No 310):1, 3-6. Unique Identifier : AIDSLINE AIDS/20700010; James JS; The Food and Drug Administration ( FDA ) announced accelerated approval of Glaxo-Wellcome s abacavir ( Ziagen , 1592) in combination with other antiretrovirals.
1999: treatments, issues to watch.: AIDS Treat News. 1999 Jan 8;(No 310):1-3. Unique Identifier : AIDSLINE AIDS/20700011; James JS; Although the future of AIDS research is unclear, there are several treatment issues that need to be addressed. One drug that is in development is T-20, an antiviral which may be especially useful to those who have HIV-1 or who have already undergone HIV treatment. Research is also underway to study the body s ability
Improving drug development: exploratory clinical studies.: AIDS Treat News. 1999 Jan 8;(No 310):6. Unique Identifier : AIDSLINE AIDS/20700012; James JS; The problems that occurred during the development process of abacavir and the limitations of the data that resulted from that process can indicate ways to improve future research. For instance, researchers need to explore how to design a study with mo
Robert Gallo calls for new treatment approach.: AIDS Treat News. 1999 Jan 8;(No 310):6-7. Unique Identifier : AIDSLINE AIDS/20700013; Dr. Robert Gallo of the University of Maryland s Institute of Human Virology hopes to develop natural, patient-friendly, nontoxic treatments. It is hoped that these treatments will also be economically affordable for those who are unable to afford current treatments. The United Nations predicts that by 2015 there will
Writer needs help: legal defense fund.: AIDS Treat News. 1999 Jan 8;(No 310):8. Unique Identifier : AIDSLINE AIDS/20700014; James JS; A reporter who focuses on gay and lesbian youth issues and HIV/AIDS was arrested by the Sacramento Police Department during a sting operation to catch online pedophiles. Bruce Mirken was investigating a story about a gay teenager when he agreed to meet with a teenager that he had been communicating with online. The te
San Francisco: HMO coverage of acupuncture.: AIDS Treat News. 1999 Jan 8;(No 310):8. Unique Identifier : AIDSLINE AIDS/20700015; In 1995, the city of San Francisco passed legislation to provide its employees with insurance coverage for acupuncture and prescribed herbs. The goal was to encourage HMOs to incorporate traditional Chinese medicine into Western care. However, because of the way the law was implemented, the city ended up providing sep
New healthcare economics threaten HIV specialization, patient choice, & quality care.: AIDS Treat News. 1999 Jan 22;(No 311):1-4. Unique Identifier : AIDSLINE AIDS/20700016; James JS; Changes in managed care programs have forced many HIV physicians to spend a significant amount of time on non-HIV cases to support their practices. HIV patients are more negatively impacted than other high-cost patients, such as those with cancer or diabetes, because HIV is treated as part of primary care rather than
A visit to India: drug prices, research, & global access.: AIDS Treat News. 1999 Jan 22;(No 311):6-8. Unique Identifier : AIDSLINE AIDS/20700017; Scondras D; Drugs manufactured in India are 1,000 to 4,000 percent cheaper than the same product in U.S. pharmacies. Because of the possible effect on profits, drug companies are working hard to stop India and other nations that make inexpensive copies of lifesaving medicines. Most drugs are in
6 HIV riddles intersect at ICAAC.: J Int Assoc Physicians AIDS Care. 1998 Dec;4(12):4-27. Unique Identifier : AIDSLINE AIDS/20700018; Mascolini M; Recurring themes at the 38th ICAAC conference were new drugs, new toxicities, renewed immunity, resistance, adherence, and salvage therapy. Speedy and effective treatment for the newly infected was discussed, and diverging opinions were voiced on whether it is best to hit the disease hard and early or defer treatment
If silence = death, will numbers = answers?: J Int Assoc Physicians AIDS Care. 1998 Dec;4(12):28-30. Unique Identifier : AIDSLINE AIDS/20700019; Miskell B; The HIV Treatment Data Project (TDP) is an internet study that asks patients to self-report treatment, symptoms, and side effects. By tracking the experiences of many patients, TDP hopes to influence clinical strategies and minimize the need for lengthy clinical trials. Patients will report data on their clinical outc
Therapeutic options or antiretroviral anarchy?: J Int Assoc Physicians AIDS Care. 1999 Jan;5(1):10-30. Unique Identifier : AIDSLINE AIDS/20700020; Mascolini M; The number of drug combinations being used to treat HIV infections may produce a public health nightmare by creating multidrug resistance. The issue of whether to use aggressive multidrug combinations early in the infectious cycle or whether to delay treatment as long as possible remains controversial and unresolved.
Report on HIV/AIDS from IDSA: news from the mile high city.: Hopkins HIV Rep. 1999 Jan;11(1):1, 4, 7. Unique Identifier : AIDSLINE AIDS/20700021; Bartlett JG; HIV/AIDS was the subject of some of the presentations at the annual meeting of the Infectious Diseases Society of America (ISDA). The most significant presentation was by Dr. Anthony Fauci, who described the possibility of using IL-2 to purge latently-infected CD4 cell
The new drugs and how to use them.: Hopkins HIV Rep. 1999 Jan;11(1):2, 7. Unique Identifier : AIDSLINE AIDS/20700022; Gallant JE; More antiretroviral drugs are becoming available, increasing potential treatment regimens but also increasing the complexity of HIV treatment. The 4 newest of the 15 available antiretroviral agents are described: efavirenz (
Hepatitis C virus and HIV co-infection: a sleeping giant wakes.: Hopkins HIV Rep. 1999 Jan;11(1):3, 10-2. Unique Identifier : AIDSLINE AIDS/20700023; Sulkowski MS; Advances in HIV therapy have greatly reduced the incidence of HIV-related complications and mortality, but co-infection with hepatitis C (HCV) virus is becoming more visible. The two infections share transmission routes, with injection drug users and transfusion patients the most commonly infected. Although sexual tra
The restless tide: the HIV pandemic.: Hopkins HIV Rep. 1999 Jan;11(1):5, 9. Unique Identifier : AIDSLINE AIDS/20700024; Quinn TC; The second decade of the AIDS epidemic shows that the disease has proliferated at shocking speed, with an estimated 47 million people now infected. In spite of news that HIV medications have reduced the spread of infection in developed countries, the dramatic increases in Asia and sub-Saharan Africa show how dangerous
Product information.: Hopkins HIV Rep. 1999 Jan;11(1):6. Unique Identifier : AIDSLINE AIDS/20700025; Bartlett JG; Information is provided on efavirenz ( Sustiva , formerly DMP-266), including dosage information, resistance and clinical trial results, and pharmacology. Side effects are reviewed, as
Treatment of HIV related weight loss.: Hopkins HIV Rep. 1999 Jan;11(1):8-9. Unique Identifier : AIDSLINE AIDS/20700026; Cofrancesco J Jr; Weight loss is a significant problem with HIV and AIDS patients. The definition of wasting syndrome is provided. Men and women do not lose weight and body mass in the same way; the differences between the genders are reviewed. Treatment includes insuring an adequate oral intake of calories, correcting malabsorption pr
ACTG adult clinical trials unit at Johns Hopkins.: Hopkins HIV Rep. 1999 Jan;11(1):suppl 1-4. Unique Identifier : AIDSLINE AIDS/20700027; Brief descriptions are provided on clinical trials being conducted at Johns Hopkins. The drugs being studied, participation requirements, and time commitments are provided. The trials cover treatment of HIV-1 disease, complications related to HIV-1 infection, investigative services clinical trials, neurology and ocula
Valuable clinical tips from recent medical meetings.: Body Posit. 1999 Feb;12(2):13-4. Unique Identifier : AIDSLINE AIDS/20700028; Prescott LM; Recent medical meetings have included presentations on dietary, pharmacologic, and biotechnological studies that have immediate value in improving the life span or health of persons with HIV. Several of these advances are highlighted, such as famciclovir has been approved for herpes treatment in HIV-infected people an
Life beyond disability.: Body Posit. 1999 Feb;12(2):16-7. Unique Identifier : AIDSLINE AIDS/20700029; Larson P; Significant numbers of people with HIV are physically feeling better and would like to return to work but are concerned about losing their disability-related benefits. If they return to work and forfeit coverage, and then their health declines, they could be left with inadequate benefits. Issues to explore when making
Keep covered.: Body Posit. 1999 Feb;12(2):18-25. Unique Identifier : AIDSLINE AIDS/20700030; Medical insurance should be a primary consideration when a person with HIV is planning a return to the workforce. Regulatory issues are reviewed, emphasizing those from New York State. Medicare pitfalls and solutions are outlined, and AIDS Drug Assistance Plan (ADAP) eligibility is spelled out. The process for continu
The road back - one step at a time.: Body Posit. 1999 Feb;12(2):26-30. Unique Identifier : AIDSLINE AIDS/20700031; As people with HIV return to the work force in significant numbers, they can face a difficult transition. HIV symptoms, such as the inability to concentrate and intermittent fatigue, may interfere with work. HIV-positive people are advised to document their symptoms and learn as much as possible about their public and
State of emergency: HIV/AIDS among African Americans.: Body Posit. 1999 Feb;12(2):32-5. Unique Identifier : AIDSLINE AIDS/20700032; Maldonado M; HIV medical care has improved the health and the quality of life for many people with HIV, but African Americans are not experiencing the full benefits of these advances. AIDS is still the leading cause of death in African Americans between the ages of 25 and 44, and African American women account for 56 percent of th
CDC wants all States to add HIV to current AIDS surveillance programs. Centers for Disease Control and Prevention.: AIDS Alert. 1999 Feb;14(2):13-7. Unique Identifier : AIDSLINE AIDS/20700033; The Centers for Disease Control and Prevention (CDC) recommends that all States include HIV cases in their AIDS surveillance programs, which could add 200,000 people to the overall surveillance count. Thirty-two States already perform HIV surveillance, but three of them collect only pediatric information. There are no
CDC recommends new guidelines for HIV tracking. Centers for Disease Control and Prevention.: AIDS Alert. 1999 Feb;14(2):17-8. Unique Identifier : AIDSLINE AIDS/20700034; The Centers for Disease Control and Prevention (CDC) issued guidelines recommending that States conduct HIV infection case surveillance. The report includes revised case definitions for HIV in adults and children. The guidelines recommend that States collect standard sets of data for all cases of HIV and AIDS, includi
Testosterone therapy can improve mood, energy.: Unique Identifier : AIDSLINE AIDS/20700035; Columbia University researchers report significant improvements in mood, energy levels, libido, and muscle mass among HIV-positive men treated with testosterone therapy. The 8-week trial program was extended 4 additional weeks for persons who responded to therapy. The study had 112 male participants; no women were inc
Doctors should coordinate use of alternative therapies.: AIDS Alert. 1999 Feb;14(2):20-3. Unique Identifier : AIDSLINE AIDS/20700036; Nearly half of the U.S. population uses alternative medicine, and for people with HIV/AIDS, that figure may be up to 70 percent. Because of the potential effects of alternative treatments, physicians need to learn about these medicines and ask patients whether they are using them. One study that is addressed collected
East clashes with West in approach to HIV treatment.: AIDS Alert. 1999 Feb;14(2):22. Unique Identifier : AIDSLINE AIDS/20700037; Many alternative treatments for HIV disease have grown out of traditional Chinese or ayurvedic medicine. However, many practitioners of Western medicine regard alternative medicine with hostility. Whereas Western HIV treatments are aimed at fighting the virus, Chinese medicine focuses on bolstering the patient s immun
Study to track benefits of compliance intervention.: AIDS Alert. 1999 Feb;14(2):23-4. Unique Identifier : AIDSLINE AIDS/20700038; The main reason people fail their HIV treatment is lack of adherence to their prescribed regimen. Judith A. Erlen of the University of Pittsburgh School of Nursing will conduct a study on how habit training, problem solving, and intervention can affect patient adherence to protease inhibitor therapy. The study will be
People with HIV misunderstand viral-load tests.: AIDS Alert. 1999 Feb;14(2):suppl 1-2. Unique Identifier : AIDSLINE AIDS/20700039; Three-quarters of the HIV-positive people surveyed know their viral load counts according to a study conducted by Roche Diagnostics, but nearly half do not know how often testing should be done. Two-thirds of the patients surveyed also did not know when viral load tests should not be conducted, such as when the patien
HIV-negative moms may present higher transmission risk.: AIDS Alert. 1999 Feb;14(2):suppl 1-3. Unique Identifier : AIDSLINE AIDS/20700040; Although interventions aimed at preventing HIV transmission have focused on HIV-positive pregnant women, a larger group is also at risk: HIV-negative pregnant women. These women are at risk of becoming infected unknowingly and transmitting the disease to their infants. Forced sexual abstinence before and after deliver
'Ideal' microbicide may be best form of protection.: AIDS Alert. 1999 Feb;14(2):suppl 3-4. Unique Identifier : AIDSLINE AIDS/20700041; AIDS vaccines are a long way from being commercially available, however, microbicides may be a viable way to help prevent HIV transmission. In several observational studies microbicides have performed well, but in two controlled studies there was no decrease in infection rates. Nonoxynol-9 (N-9) may be able to kill pa
Dentist again loses in bias case; vows new appeal to Supreme Court.: AIDS Policy Law. 1999 Jan 22;14(1):1, 4-5. Unique Identifier : AIDSLINE AIDS/20700042; The U.S. Supreme Court upheld that the American with Disabilities Act (ADA) can protect a person with asymptomatic HIV but asked the First U.S. Circuit Court of Appeals to review part of its previous decision. Upon review, the U.S. Circuit Court upheld its earlier decision that dentist Randon Bragdon violated the ADA
Despite demand, employer interest in AIDS education wanes.: AIDS Policy Law. 1999 Jan 22;14(1):2. Unique Identifier : AIDSLINE AIDS/20700043; A survey of 2,000 adults, commissioned by the National AIDS Fund, found that AIDS remains a top health concern in the workplace, but fewer employers are offering workplace education programs. AIDS education reduces the risk of employer liability, avoids interruptions in productivity, and reduces anxiety about on-the-j
Homeless shelter agrees to educate clients about AIDS.: AIDS Policy Law. 1999 Jan 22;14(1):3. Unique Identifier : AIDSLINE AIDS/20700044; Rather than facing litigation for evicting a man with AIDS, a homeless shelter agreed to educate clients and staff about HIV. Patrick Biggers, a person with AIDS, was evicted from the Emmaus Center after staff and residents voiced fears that they would be exposed to infection. The American Civil Liberties Union (ACLU)
Judge orders mother to give baby AZT, stop breast-feeding.: AIDS Policy Law. 1999 Jan 22;14(1):5. Unique Identifier : AIDSLINE AIDS/20700045; A Lane County Circuit Court judge in Oregon ordered Kathleen Tyson to comply with her doctor s wishes to treat her newborn with AZT and to stop breast-feeding. The parents opposed the use of AZT because of possible side effects. The newborn has his mo
Hypodermic needle, plus AIDS threat, equals deadly weapon.: AIDS Policy Law. 1999 Jan 22;14(1):7. Unique Identifier : AIDSLINE AIDS/20700046; Robert Ainis was sentenced by the New Jersey Superior Court to 11 years in prison for robbing a convenience store and brandishing a hypodermic needle while threatening to inject the clerk with AIDS. The New Jersey Superior Court ruled that using the needle in that manner, combined with the threat to deliberately infec
Guilty plea in needle case ends syringe swap program.: AIDS Policy Law. 1999 Jan 22;14(1):7. Unique Identifier : AIDSLINE AIDS/20700047; The executive director of a needle-exchange project received a 90-day suspended sentence on a charge of illegally distributing hypodermic syringes. In exchange for the suspended sentence, Diane McCague of the Chai Project had to shut down her program. Her sentence also included paying a fine of nearly $800, performing
HIV/AIDS and the States: a look at laws enacted in 1998.: AIDS Policy Law. 1999 Jan 22;14(1):8-13. Unique Identifier : AIDSLINE AIDS/20700048; This annual review of legislation tracks major developments in HIV policies at the State level. State legislatures appeared to have two primary objectives in 1998: surveillance programs and punishment for those who knowingly spread HIV. Legislative actions are arranged by topic, including criminal exposure and partner
Testing of defendant is valid even 18 months after the crime.: AIDS Policy Law. 1999 Jan 22;14(1):13. Unique Identifier : AIDSLINE AIDS/20700049; Eighteen months after his alleged sexual offenses against a child, David Isom was ordered by a Brevard County trial judge to be tested for HIV. The testing was requested by the guardians of the victim. On appeal, Isom argued that testing now would provide useless information since the law mandated testing to allow the
L.A. County settles suit by Healthcare Foundation.: AIDS Policy Law. 1999 Jan 22;14(1):14. Unique Identifier : AIDSLINE AIDS/20700050; The Los Angeles County Board of Supervisors agreed to pay a $1.2 million settlement to the AIDS Healthcare Foundation, which charged that the county eliminated much of its funding in retribution for a series of protests criticizing county officials for cutting AIDS services funding. The foundation produced an audio re
For biting to be a felony, attacker must have HIV.: AIDS Policy Law. 1999 Jan 22;14(1):14. Unique Identifier : AIDSLINE AIDS/20700051; The Ohio Court of Appeals vacated the conviction of Constance Reif-Hill, who resisted routine blood testing on admission to a psychiatric hospital. The blood test was required to determine her alcohol and medication levels. Reif-Hill became highly agitated, telling staff that she had AIDS. She then bit one employee, p
HIV transfusion suit killed because blood was the patient's.: AIDS Policy Law. 1999 Jan 22;14(1):15. Unique Identifier : AIDSLINE AIDS/20700052; A New York Supreme Court ruled against a patient who claimed to have received HIV from a blood transfusion. The patient, identified as John Doe, donated four units of his own blood prior to cardiac surgery. Doe argued that he was given blood from someone else and then contracted HIV. All of the evidence showed that th
HIV reporting.: AIDS Policy Law. 1999 Jan 22;14(1):16. Unique Identifier : AIDSLINE AIDS/20700053; The California debate over HIV surveillance resumed with the introduction of a bill to use coded identifiers to track HIV infections. Bill 103 is similar to another bill vetoed by Gov. Pete Wilson in 1998. Wilson favors name-based reporting. The new governor, Democrat Gray Davis, appears more open to using unique iden
Life sentence.: AIDS Policy Law. 1999 Jan 22;14(1):16. Unique Identifier : AIDSLINE AIDS/20700054; Brian Stewart, convicted of first-degree assault for injecting his infant son with HIV-contaminated blood, has been sentenced to life in prison. Stewart, who will be eligible for parole in 15 years, plans to appeal the verdict. It was alleged that Stewart injected the boy to avoid child support payments. His son is no
Lawsuit settled.: AIDS Policy Law. 1999 Jan 22;14(1):16. Unique Identifier : AIDSLINE AIDS/20700055; Charlene Riling settled her lawsuit against a physician whom she claimed misdiagnosed her with AIDS. Riling went to the doctor with a low-grade fever, swollen glands, headaches, coughing, and digestive problems, and told the doctor she had previously received a positive HIV test result. The doctor did not confirm the
Glutamania-is there anything Glutamine doesn't do?: Notes Undergr. 1998-99 Winter;(No 38):1-4. Unique Identifier : AIDSLINE AIDS/20700056; Szalavitz M; Glutamine, a nutritional supplement, has been acclaimed to stop diarrhea and wasting, enhance muscularity, promote immune cell growth, and possibly slow HIV progression. It is most commonly used with anti-oxidants, which help relieve oxidative stress and neutralize chemicals that are built up in the bloodstream as a r
Anti-HIV medications + street drugs: some cocktails don't mix.: Notes Undergr. 1998-99 Winter;(No 38):1, 4-5. Unique Identifier : AIDSLINE AIDS/20700057; The combination of HIV medications and street drugs not only taxes the liver and/or kidneys, but can be lethal. Several potential interactions are discussed. One dangerous combination is when ecstasy (X, MDMA) is taken with any protease inhibitor or non-nucleoside reverse transcriptase inhibitor. Sedatives, barbiturat
Pain medications and recovery.: Notes Undergr. 1998-99 Winter;(No 38):6-7. Unique Identifier : AIDSLINE AIDS/20700058; Szalavitz M; Pain medication is an important part of healing, and concerns about relapsing into addiction can be destructive. Patients should inform their doctor about previous addictions and can investigate other avenues of pain management, such as acupuncture or massage. If these methods do not prove effective, patients should f
Hepatitis treatment update: new approvals, not much news.: Notes Undergr. 1998-99 Winter;(No 38):7-8. Unique Identifier : AIDSLINE AIDS/20700059; Learned J; Thymosin-Alpha-1 (Zadaxin) is a synthetic hormone that has been studied as a treatment for HIV, hepatitis B, and hepatitis C. Recently approved in Mexico as a booster for the flu vaccine, it was also approved in nine other countries for flu, hepatitis B, and hepatitis C. The demand
Protease inhibitors at a glance....: Notes Undergr. 1998-99 Winter;(No 38):suppl 1-4. Unique Identifier : AIDSLINE AIDS/20700060; Four protease inhibitors are compared: Saquinavir ( Invirase , Fortovase), Indinavir ( Crixivan
Retroviruses Conference, Chicago 1999.: AIDS Treat News. 1999 Feb 12;(No 312):1-2. Unique Identifier : AIDSLINE AIDS/20700061; James JS; The 6th Conference on Retroviruses and Opportunistic Infections was the largest AIDS scientific meeting of 1999. It provided an overview of the current state of basic and applied medical science related to the disease. Promising drugs are in development, and HIV-specific immunity remains an important area of study. Ot
Restoring HIV-specific immunity.: AIDS Treat News. 1999 Feb 12;(No 312):2-6. Unique Identifier : AIDSLINE AIDS/20700062; James JS; When HIV is controlled with antiretrovirals, immunity to other infections often returns. Sometimes patients can stop prophylactic treatment, and sometimes opportunistic infections can clear up without treatment. However, immunity to HIV itself does not return, or returns very slowly, even when HIV has been suppressed
Global patent police block cost-reduction efforts.: GMHC Treat Issues. 1999 Mar;13(3):1-2. Unique Identifier : AIDSLINE AIDS/20700063; Kasper T; Sub-Saharan Africa has been seriously affected by the AIDS epidemic, with infection rates exceeding 30 percent in some areas. Unfortunately, most of the drugs used for treatment in the United States are not available in other countries because of high costs. The high costs can be attri
HAL in 2001: a fat oddity.: GMHC Treat Issues. 1999 Mar;13(3):2-5, 8. Unique Identifier : AIDSLINE AIDS/20700064; Grinberg L; Torres G; HIV-associated lipodystrophy (HAL) is a side effect of successful viral suppression using highly active antiretroviral therapy (HAART). HAL manifests itself through a variety of changes in body composition and metabolism. Changes include unusual fat redistribution throughout the body and altered mechanics of fat metab
Pregnant women's urine analyzed for antiviral agents.: GMHC Treat Issues. 1999 Mar;13(3):6-7. Unique Identifier : AIDSLINE AIDS/20700065; Commercial preparations of human chorionic gonadotropin (HCG) inhibit growth of Kaposi s sarcoma (KS) in laboratory animals and test tube cultures. HCG is made from the urine of pregnant women, who secrete large quantities of the hormone during their first trimester. The actual mechanisms at work with HCG are still un
Fat, sugar and drugs on the French Riviera.: GMHC Treat Issues. 1999 Mar;13(3):9-11. Unique Identifier : AIDSLINE AIDS/20700066; Lands L; The 3rd International Conference on Nutrition and HIV Infection emphasized lipodystrophy and the metabolic implications of highly active antiretroviral therapy (HAART). Several presentations challenged the idea that protease inhibitors alone caused lipodystrophy. Th
Protease inhibitors, sexual dysfunction and Viagra.: GMHC Treat Issues. 1999 Mar;13(3):12. Unique Identifier : AIDSLINE AIDS/20700067; Gilden D; Impotence is often associated with protease inhibitor use, but much of the medical press ignored this issue until Spanish doctors described sexual difficulties following protease inhibitor therapy in 14 of 260 patients. Causes of sexual dysfunction in HIV-infected men are difficult to isolate but may also be traced to
Peripheral facial paralysis revealing HIV infection [letter]: Unique Identifier : AIDSLINE MED/20062240; Vanpee D; Gillet JB; Laloux P
A placenta-derived suppressor factor with a T-cell bias [see comments]: Am J Reprod Immunol. 1999 Oct;42(4):205-18. Unique Identifier : AIDSLINE MED/20046547; Raghupathy R; Khan SF; Syamasundar PV; Bansal P; Azizieh F; Department of Microbiology, Faculty of Medicine, Kuwait; University. raj@hsc.kuniv.edu.kw; PROBLEM: Functional and mechanistic aspects of immunosuppression by murine placental supernatants (MPS) were investigated. METHOD OF STUDY: MPS and a low molecular weight fraction of the supernatant (MPSf) were tested for suppressive action on T-cell reactivity in vitro and in vivo, on B-cell responses and on T-cell a
Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells.: Am J Reprod Immunol. 1999 Oct;42(4):240-5. Unique Identifier : AIDSLINE MED/20046551; Saito S; Tsukaguchi N; Hasegawa T; Michimata T; Tsuda H; Narita N; Department of Obstetrics and Gynecology, Toyama Medical and; Pharmaceutical University, Japan. s30saito@m.s.toyama-mpu.ac.jp; PROBLEM: To examine whether normal pregnancy involves type 2 T-helper (Th2) immune condition or not. METHOD OF STUDY: We measured the percentage of Th0, Th1, and Th2 and the Th1/Th2 cell ratios of human peripheral blood and endometrial T cells using flow cytometry, which can analyze both the surface marker CD3, and in
Membrane destabilization assay based on potassium release from liposomes.: Biochim Biophys Acta. 1999 Nov 9;1461(1):103-12. Unique Identifier : AIDSLINE MED/20025447; Silberstein A; Mirzabekov T; Anderson WF; Rozenberg Y; Gene Therapy Laboratories, School of Medicine, University of; Southern California, 1441 EastLake Ave., Room 610, Los Angeles,; CA, USA.; Inorganic ions are highly suitable markers for monitoring release of the inner content of liposomes. In the present study, a potassium (K(+)) selective electrode was used to evaluate the rate of K(+) release from large unilamellar vesicles (LUV). The developed method is highly sensitive, reproducible and inexpensive.
Regulation of HIV-1 transcription.: Gene Expr. 1999;8(2):67-84. Unique Identifier : AIDSLINE MED/20017958; Roebuck KA; Saifuddin M; Department of Immunology/Microbiology, Rush Presbyterian St.; Luke's Medical Center, Chicago, IL 60612, USA. kroebuck@rush.edu; Human immunodeficiency virus type-1 (HIV-1) is a highly pathogenic lentivirus that requires transcription of its provirus genome for completion of the viral life cycle and the production of progeny virions. Since the first genetic analysis of HIV-1 in 1985, much has been learned about the transcriptional regulation of
Patterns of relative cerebral blood flow in minor cognitive motor disorder in human immunodeficiency virus infection.: J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):222-33. Unique Identifier : AIDSLINE MED/99266535; Wiseman MB; Sanchez JA; Buechel C; Mintun MA; Lopez OL; Milko D; Becker JT; Neuropsychology Research Program, University of Pittsburgh; Medical Center, Pennsylvania, USA.; Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia , others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood
The role of precise conceptualization in the treatment of a complicated HIV-1-infected neuropsychiatric patient.: J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):234-40. Unique Identifier : AIDSLINE MED/99266536; LoPiccolo CJ; Goodkin K; Department of Psychiatry and Behavioral Sciences, University of; Miami School of Medicine, Florida 33136, USA.; Patients infected with human immunodeficiency virus, type 1, may present with neuropsychiatric manifestations across all stages of disease. Frequently, these patients may present with more than one neuropsychiatric disorder concomitantly. The case presented highlights the utility of detailed clinical observation, care
Spatial working memory in asymptomatic HIV-infected subjects.: J Neuropsychiatry Clin Neurosci. 1999 Summer;11(3):387-91. Unique Identifier : AIDSLINE MED/99368889; Grassi B; Garghentini G; Campana A; Grassi E; Bertelli S; Cinque P; Epifani M; Lazzarin A; Scarone S; Psychiatric Branch, Centro San Luigi, University of Milan Medical; School, Italy.; Many clinical and research findings converge to indicate that frontal lobe, basal ganglia, and related neuronal connections are primarily involved in human immunodeficiency virus (HIV) infection; frontal lobe, mainly the prefrontal cortex, has a specialized role in working memory processes. This study focused on neuro
Induction of IgE responses using a recombinant mosquito salivary allergen rAed a 2 without adjuvant in mice.: Int Arch Allergy Immunol. 1999 Oct;120(2):135-40. Unique Identifier : AIDSLINE MED/20014682; Wang H; Mao X; Simons FE; Peng Z; Section of Allergy and Clinical Immunology, Department of; Pediatrics and Child Health, Winnipeg, Canada.; BACKGROUND: Reactions to mosquito bites are a global problem. Several salivary proteins from Aedes (Ae.) aegypti, the most common mosquito species, have been cloned and expressed. Plasmid DNA vaccination has been shown to be effective in the downregulation of IgE responses. To investigate the in vivo antigenicity of t
Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance.: Brain Res Cogn Brain Res. 1999 Oct 25;8(3):185-201. Unique Identifier : AIDSLINE MED/20025662; Weed MR; Taffe MA; Polis I; Roberts AC; Robbins TW; Koob GF; Bloom FE; Gold LH; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA, USA.; A computerized behavioral battery based upon human neuropsychological tests (CANTAB, CeNeS, Cambridge, UK) has been developed to assess cognitive behaviors of rhesus monkeys. Monkeys reliably performed multiple tasks, providing long-term assessment of changes in a number of behaviors for a given animal. The overall go
Health situation in former communist bloc is dire, says Unicef [news]: BMJ. 1999 Nov 20;319(7221):1324. Unique Identifier : AIDSLINE MED/20035246; Ciment J
Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly.: J Gastroenterol. 1999 Dec;34(6):706-12. Unique Identifier : AIDSLINE MED/20053410; Kojima K; Nagayama R; Hirama S; Maeda T; Takikawa H; Miyake K; Yamanaka M; Shiga J; Department of Medicine, Teikyo University School of Medicine,; Tokyo, Japan.; A 73-year-old man had fever, lymphadenopathy, granulocytopenia, thrombocytopenia, ascites, pleural effusion, liver injury, and an allergic-like skin rash. Autoantibodies, such as anti-nuclear antibody, were shown, and there were lactate dehydrogenase and alkaline phosphatase anomalies and platelet-associated IgG. His
Preliminary comparison of precursor scans and liquid chromatography-tandem mass spectrometry on a hybrid quadrupole time-of-flight mass spectrometer.: J Chromatogr A. 1999 Aug 27;854(1-2):119-30. Unique Identifier : AIDSLINE MED/99426221; Borchers C; Parker CE; Deterding LJ; Tomer KB; Laboratory of Structural Biology, National Institute of; Environmental Health Sciences, National Institutes of Health,; Research Triangle Park, NC 27709, USA.; Recent mass spectrometry instrumentation developments include the appearance of novel hybrid tandem instrumentation, Q-TOF, consisting of a quadrupole mass analyzer (MS1) and a time-of-flight (TOF) analyzer. The TOF analyzer is not scanned, but collects all fragment ions entering the analyzer at a given time. Thus, th
Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.: Curr Biol. 1999 Aug 26;9(16):861-8. Unique Identifier : AIDSLINE +; Barbulescu M; Turner G; Seaman MI; Deinard AS; Kidd KK; Lenz J; Department of Molecular Genetics, Albert Einstein College of; Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.; BACKGROUND: Endogenous retroviruses contribute to the evolution of the host genome and can be associated with disease. Human endogenous retrovirus K (HERV-K) is related to the mouse mammary tumor virus and is present in the genomes of humans, apes and cercopithecoids (Old World monkeys). It is unknown how long ago in
AIDS-related services and training in outpatient mental health care agencies in New York.: Psychiatr Serv. 1999 Sep;50(9):1225-8. Unique Identifier : AIDSLINE MED/99406027; McKinnon K; Cournos F; Herman R; Satriano J; Silver BJ; Puello I; Columbia University College of Physicians and Surgeons and the; Washington Heights Community Service of the New York State; Psychiatric Institute, New York 10032, USA. kmm49@columbia.edu; Directors of 471 outpatient mental health settings in New York State (82.1 percent of 574 settings located in counties with intermediate to high AIDS case rates) completed a survey about HIV and AIDS services, training needs, and barriers to care. Most of the sites served one to ten persons with HIV infection annually
Procoagulant expression in platelets and defects leading to clinical disorders.: Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2841-6. Unique Identifier : AIDSLINE MED/20060032; Solum NO; Research Institute for Internal Medicine, Rikshospitalet,; University of Oslo, Oslo, Norway. n.o.solum@rh.uio.no; Hemostasis is a result of interactions between fibrillar structures in the damaged vessel wall, soluble components in plasma, and cellular elements in blood represented mainly by platelets and platelet-derived material. During formation of a platelet plug at the damaged vessel wall, factors IXa and VIIIa form the ten
Cytokine and cytokine receptor concentrations in bone marrow supernatant from patients with HIV: correlation with hematologic parameters.: J Investig Med. 1999 Nov;47(9):477-83. Unique Identifier : AIDSLINE MED/20038517; Dallalio G; North M; McKenzie SW; Means RT Jr; Division of Hematology/Oncology, Ralph H. Johnson VA Medical; Center, Charleston SC, USA.; BACKGROUND: To determine the concentrations of tumor necrosis factor (TNF) alpha, soluble TNF receptors (sTNFR), interleukin (IL)-1 beta, gamma-interferon (IFN), macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES to which hematopoietic progenitors are exposed in vivo in HIV patients and the correlat
The hairpin ribozyme. Discovery, mechanism, and development for gene therapy.: Mol Biotechnol. 1999 Aug;12(1):117-29. Unique Identifier : AIDSLINE MED/20022426; Shippy R; Lockner R; Farnsworth M; Hampel A; Department of Biological Sciences, Northern Illinois University,; DeKalb 60115, USA.; The hairpin ribozyme is a member of a family of small RNA endonucleases, which includes hammer-head, human hepatitis delta virus, Neurospora VS, and the lead-dependent catalytic RNAs. All these catalytic RNAs reversibly cleave the phosphodiester bond of substrate RNA to generate 5 -hydroxyl and 2 ,3 -cyclic phosphate
Replacing competition with cooperation [editorial]: Nat Med. 1999 Dec;5(12):1329. Unique Identifier : AIDSLINE MED/20048122
Viral phenotype and CCR5 genotype [letter]: Nat Med. 1999 Dec;5(12):1330. Unique Identifier : AIDSLINE MED/20048125; Michael NL; Moore JP
Ancient HTLV-1 [news; comment]: Nat Med. 1999 Dec;5(12):1357. Unique Identifier : AIDSLINE MED/20048151; Novak K
A new HIV hideout [news]: Nat Med. 1999 Dec;5(12):1358. Unique Identifier : AIDSLINE MED/20048152; Mariani S
The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy.: Nat Med. 1999 Dec;5(12):1428-32. Unique Identifier : AIDSLINE MED/20048165; Li HC; Fujiyoshi T; Lou H; Yashiki S; Sonoda S; Cartier L; Nunez L; Munoz I; Horai S; Tajima K; Department of Virology, Faculty of Medicine, Kagoshima; University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.; The worldwide geographic and ethnic clustering of patients with diseases related to human T-cell lymphotropic virus type I (HTLV-I) may be explained by the natural history of HTLV-I infection. The genetic characteristics of indigenous people in the Andes are similar to those of the Japanese, and HTLV-I is generally de
Effective delivery of a lipophilic 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) into rat lymphoid tissues.: Exp Anim. 1999 Oct;48(4):241-6. Unique Identifier : AIDSLINE MED/20058532; Fujii Y; Akari H; Machida M; Kojima E; Murakami K; Yoshikawa Y; Iwakuni Research Laboratory, Nippon Paper Industries Co., Ltd.,; Yamaguchi, Japan.; Lipophilic 6-chloro-2 ,3 -dideoxyguanosine (6-Cl-ddG) was evaluated for its improved lymph node delivery by comparison with the parental nucleoside (ddG) in vitro and in vivo. The in vitro studies with rat plasma, lymph node homogenate and stomach content indicated that 6-Cl-ddG converted to ddG more effectively in th
Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease.: Diabetes Metab. 1999 Nov;25(5):383-92. Unique Identifier : AIDSLINE MED/20060445; Vigouroux C; Gharakhanian S; Salhi Y; Nguyen TH; Adda N; Rozenbaum W; Capeau J; Service de Biochimie, Hopital Rothschild, Paris, France.; capeau@st-antoine.inserm.fr; Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i
Tolerability of an extract of European mistletoe among immunocompromised and healthy individuals.: Unique Identifier : AIDSLINE MED/20018567; Gorter RW; van Wely M; Reif M; Stoss M; CONTEXT: European mistletoe (Viscum album L) has been used parenterally for more than 80 years as an anticancer medication with significant immunomodulating action. Since 1984, clinical experience with a Viscum album extract (Viscum album Quercus Frischsaft [Qu FrF]) among HIV-positive patients has suggested that it i
Patterns of central nervous system recurrence in patients with systemic human immunodeficiency virus-associated non-hodgkin lymphoma.: Cancer. 1999 Nov 1;86(9):1840-7. Unique Identifier : AIDSLINE MED/20016314; Desai J; Mitnick RJ; Henry DH; Llena J; Sparano JA; Department of Radiation Oncology, Albert Einstein Comprehensive; Cancer Center, Montefiore Medical Center, Bronx, New York 10467,; USA.; BACKGROUND: Central nervous system involvement is a common manifestation of non-Hodgkin lymphoma (NHL) in human immunodeficiency virus (HIV)-infected individuals. The purpose of this study was to review the frequency and pattern of neurologic manifestation of lymphoma in a cohort of HIV-infected individuals with syste
Clinical efficacy of protease inhibitor based antiretroviral combination therapy--a prospective cohort study.: Eur J Med Res. 1999 Nov 22;4(11):449-55. Unique Identifier : AIDSLINE MED/20054892; Salzberger B; Rockstroh J; Wieland U; Franzen C; Schwenk A; Jutte A; Hegener P; Cornely O; Morchen C; Gaensicke T; Diehl V; Fatkenheuer G; Klinik I fur Innere Medizin, Universitatsklinik Koln, D-50924; Koln, Germany. bernd.salzberger@uni-koeln.de; OBJECTIVES: To analyze virological and clinical efficacy of protease inhibitor based antiretroviral regimens in a cohort of unselected HIV-infected patients. METHODS: Prospective analysis of all HIV-infected patients started on protease inhibitor therapy until August 31, 1997 in two outpatient clinics. Partial viral s
Antiretroviral therapy (ART) from a neurological point of view. German Neuro-AIDS study group (DNAA).: Eur J Med Res. 1999 Nov 22;4(11):456-62. Unique Identifier : AIDSLINE MED/20054893; Enzensberger W; von Giesen HJ; Neurologische Klinik der Heinrich-Heine-Universitat Dusseldorf,; Postfach 10 10 07, D-40001 Dusseldorf, Germany.; giesenhj@uni-duesseldorf.de.; Human Immunodeficiency virus can affect the peripheral (PNS) and central nervous system (CNS). In the ART / HAART era especially the CNS is said to be a virus reservoir so that neurologists have to be more and more integrated in therapy planning. Therefore the present paper describes neurological indications for ART,
Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model.: Biol Blood Marrow Transplant. 1999;5(6):357-68. Unique Identifier : AIDSLINE MED/20061262; Ito M; Shizuru JA; Department of Medicine, Stanford University School of Medicine,; California 94305, USA.; It is known that an important curative benefit of allogeneic bone marrow transplantation (BAMT) in the treatment of hematolymphoid malignancies is a graft-vs.-tumor (GVT) effect. GVT activity has been attributed to mature immune cells contained within the graft because T-cell depletion of bone marrow results in increa
[Brain as an organ of immunity]: Zh Nevrol Psikhiatr Im S S Korsakova. 1999;99(9):62-5. Unique Identifier : AIDSLINE MED/20003453; Malashkhiia IuA; Nadareishvili ZG; Malashkhiia NIu; Malashkhiia VIu
Antibodies to the cytoplasm, cell membrane and nuclear membrane of malignant neoplasms in pooled normal human polyspecific immunoglobulin G.: Unique Identifier : AIDSLINE MED/20038240; Bar-Dayan Y; Barshack I; Blank M; Goldberg I; Levy Y; Kopolovic J; Fishman P; Shoenfeld Y; IVIg is a preparation of normal polyspecific IgG obtained from pooled plasma of a large number of healthy donors. IVIg treatment of patients with chronic lymphocytic leukemia induced a reduction
Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase BCL-2 expression.: Cell Death Differ. 1999 Oct;6(10):1002-11. Unique Identifier : AIDSLINE MED/20027821; Naora H; Gougeon ML; Unite d'Oncologie Virale and URA CNRS 1930, Departement SIDA et; Retrovirus Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris,; Cedex 15, France.; IL-15 shares many biological properties with IL-2 , a cytokine whose administration to HIV-infected individuals has been effective in enhancing depleted CD4 T lymphocyte numbers. The present study examined whether exogenous IL-15 could protect lymphocytes of HIV-infecte
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxy alcohols derived from alpha-amino acids.: Bioorg Med Chem Lett. 1999 Oct 18;9(20):3027-30. Unique Identifier : AIDSLINE MED/20035947; Benedetti F; Magnan M; Miertus S; Norbedo S; Parat D; Tossi A; Dipartimento di Scienze Chimiche, Biofisica e Chimica delle; Macromolecole, Universita di Trieste, Italy.; benedett@univ.trieste.it; (1R,2R,3S,4S)-4-Amino-3-hydroxy-1,2-epoxybutanes, accessible in four steps from L-aminoesters, react regio- and stereoselectively with diethyl aluminum cyanide to give (1R,2S,3S,4S)-4-amino-2,3-dihydroxynitriles. Hydrolysis yields hydroxylactones equivalent to 2,3-dihydroxy-4-aminoacids. The sequence provides a novel
The right to health fifty years on: still skeptical?: Health Hum Rights. 1999;4(1):6-25. Unique Identifier : AIDSLINE MED/20048204; Kirby M; The drafting of the Universal Declaration of Human Rights was a crucial step in the recognition of a legal right to health. Although the past 50 years have revealed weaknesses in the Declaration, it has been an important catalyst for social and legal change worldwide and for new thinking about public health. Recently,
Drug-induced lupus nephritis in HIV infection [letter]: Rheumatology (Oxford). 1999 Oct;38(10):1017-8. Unique Identifier : AIDSLINE MED/20006409; Smith PR; D'Cruz D; Raftery MJ; Dodd SM; Helbert M; Skinner CJ
Th1-type cytokine mRNA in rheumatoid arthritis mononuclear cells induced by streptococcal pyrogenic exotoxin A [letter]: Rheumatology (Oxford). 1999 Oct;38(10):1022-4. Unique Identifier : AIDSLINE MED/20006413; Szczepanska K; Chrzanowska-Lightowlers Z; Degnan BA; Diamond AG; Robson T; Ryzewska A; Goodacre JA
Frequency and predictors of medically attended injuries in HIV-infected children.: Clin Pediatr (Phila). 1999 Nov;38(11):625-35. Unique Identifier : AIDSLINE MED/20055093; Turner BJ; Cocroft J; Hauck WW; Schwarz DF; Casey R; Division of General Internal Medicine, Jefferson Medical College; of Thomas Jefferson University, Philadelphia, PA 19107-5083, USA.; The extent to which medically attended injuries complicate the clinical course of HIV-infected (HIV+) children is unknown. In a cohort of HIV+ children delivered from 1985 to 1990 and aged less than 60 months, we determined medically attended injuries per 100 child-years, Injury Severity Scores (ISS), and predictors o
Can HIV infection be prevented with a vaccine?: Drugs R D. 1999 Jun;1(6):431-40. Unique Identifier : AIDSLINE MED/20032510; Joy AK; Dale CJ; Kent SJ; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; The global human immunodeficiency virus type 1 (HIV-1) epidemic is devastating many communities and a well tolerated and effective vaccine is urgently required. Several lines of evident suggest that vaccine-induced protective immunity can be achieved. This evidence includes individuals shown to have natural immunity,
Prophylactic HIV vaccines. Summary and table.: Drugs R D. 1999 Jun;1(6):441-3. Unique Identifier : AIDSLINE MED/20032511; Wagstaff A; Brooke G; Adis International Limited, Auckland, New Zealand.f1
HIV gp120 vaccine (Chiron).: Drugs R D. 1999 Jun;1(6):445-7. Unique Identifier : AIDSLINE MED/20032512
HIV gp120 vaccine gene therapy (Wyeth-Lederle Vaccines-Malvern).: Drugs R D. 1999 Jun;1(6):448. Unique Identifier : AIDSLINE MED/20032513
HIV gp160 vaccine (Immuno AG).: Drugs R D. 1999 Jun;1(6):449-50. Unique Identifier : AIDSLINE MED/20032514
HIV gp160 vaccine gene therapy (Wyeth-Lederle Vaccines-Malvern).: Unique Identifier : AIDSLINE MED/20032515
HIV HGP-30W vaccine (Cel-Sci).: Drugs R D. 1999 Jun;1(6):453-5. Unique Identifier : AIDSLINE MED/20032516
HIV vaccine AIDSVAX.: Drugs R D. 1999 Jun;1(6):456-8. Unique Identifier : AIDSLINE MED/20032517
HIV vaccine vCP205. ALVAC-HIV vCP205, ALVAC vCP205.: Drugs R D. 1999 Jun;1(6):459-60. Unique Identifier : AIDSLINE MED/20032518
Immune reconstitution: is there a potential role for Filgrastim (r-metHuG-CSF).: J Hematother Stem Cell Res. 1999;8 Suppl 1:S1-2. Unique Identifier : AIDSLINE MED/20059194; Walker BD; Harvard Medical School, Charlestown, MA 02129, USA.
Clinical experience with Filgrastim in AIDS.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S17-9. Unique Identifier : AIDSLINE MED/20059197; Kuritzkes DR; University of Colorado Health Sciences Center, Denver 80262, USA.; Data have shown that neutropenia is a risk factor for severe bacterial infections. Two trials were done in HIV-infected patients to study the effect of Filgrastim on neutropenia and the incidence of severe bacterial infections. The incidence of Mycobacterium avium complex (MAC) infection in this setting was also evalu
Anti-inflammatory aspects of Filgrastim and impact on IL-2 release.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S21-2. Unique Identifier : AIDSLINE MED/20059198; Hartung T; University of Konstanz, Germany.; G-CSF has immunomodulatory effects of neutrophilic granulocytes and monocytes/macrophages. Two studies were done: one in normal volunteers and the other in HIV-infected patients plus their respective control donors to evaluate the effect of Filgrastim on cytokine responses. Filgrastim treatment of volunteers resulted
Neutropenia in patients with HIV infection: a case control study in a cohort of 1403 patients between 1982 and 1993.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S23-32. Unique Identifier : AIDSLINE MED/20059199; Hermans P; Sommereijns B; Van Cutsem N; Clumeck N; Division of Infectious Diseases, C.H.U. Saint-Pierre, Brussels,; Belgium.; The relationship between neutropenia and increased risks of severe infections in patients with HIV infection and the factors associated with neutropenia-induced infections was studied by a retrospective comparative study using matched case-control analysis. A database (1982-1993) of 1870 patients with HIV infection wa
Biopharmaceutical drug development: Filgrastim (r-metHuG-CSF) use in patients with HIV infection.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S3-8. Unique Identifier : AIDSLINE MED/20059195; Foote M; Welch W; Amgen Inc., Thousand Oaks, CA 91320-1799, USA.; Hematopoietic growth factors are well known to increase neutrophil counts and support the administration of myelotoxic and myelosuppressive therapies, especially chemotherapies. Filgrastim (r-metHuG-CSF) has been used in the setting of HIV disease to treat neutropenia and HIV-associated neutrophil defects. This articl
The use of Filgrastim in AIDS-related neutropenia.: J Hematother Stem Cell Res. 1999;8 Suppl 1:S9-16. Unique Identifier : AIDSLINE MED/20059196; Welch W; Foote M; Amgen Inc., Thousand Oaks, CA 91320-1799, USA.; Neutropenic individuals are at high risk for bacterial and fungal infections. Filgrastim (r-metHuG-CSF, NEUPOGEN) has been shown to improve chemotherapy-induced neutropenia significantly. Because a high incidence of HIV-infected patients have neutropenia, often associated with myelosuppressive antiretroviral medicatio
Women with schizophrenia and co-occurring substance use disorders: an increased risk for violent victimization and HIV.: Community Ment Health J. 1999 Oct;35(5):401-19. Unique Identifier : AIDSLINE MED/20012607; Gearon JS; Bellack AS; University of Maryland-Baltimore, Department of Psychiatry,; 21201-1549, USA. jgearon@umaryland.edu; Women with serious mental illnesses are at risk for victimization and HIV. Schizophrenia related neurocognitive and social competency deficits exacerbated by the effects of substance abuse may make women with schizophrenia particularly vulnerable. Information processing deficits may impair the ability to identify situ
Motivations for condom use: do pregnancy prevention goals undermine disease prevention among heterosexual young adults?: Health Psychol. 1999 Sep;18(5):464-74. Unique Identifier : AIDSLINE MED/99446951; Cooper ML; Agocha VB; Powers AM; Department of Psychology, University of Missouri-Columbia 65211,; USA. cooperm@missouri.edu; Differences in motives for condom use and their implications for understanding frequency of use were investigated in a random, biracial (Black, White) sample of heterosexuals, aged 17 to 25 years (n = 902). Results indicated that sexually active young adults-regardless of race, age, gender, or relationship status-were
Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity.: Eur J Immunol. 1999 Nov;29(11):3562-70. Unique Identifier : AIDSLINE MED/20025992; Potsch C; Vohringer D; Pircher H; Institute of Medical Microbiology, Department of Immunology,; University of Freiburg, Freiburg, Germany.; Changes in the migration pattern of lymphocytes represent a key event in the evolution of an immune response since they enable lymphocytes to gain access to infected tissues. We studied the location of virus-specific CD8 T cells in various splenic compartments in response to infection with lymphocytic choriomeningitis
The increased CD38 expressed by lymphocytes infected with HIV-1 is a fully active NADase.: Eur J Immunol. 1999 Nov;29(11):3583-7. Unique Identifier : AIDSLINE MED/20025994; Bofill M; Parkhouse RM; Immunology Department Royal Free Hampstead NHS Trust, London, GB.; bofill@rfhsm.ac.uk; The NADase activity of the ectoenzyme CD38 on intact cells has been measured by a fluorometric assay using epsilon-NAD as a substrate. The enzyme activity was tested in the Daudi cell line, PHA-activated blasts and peripheral blood and tonsil lymphocytes from HIV-1-negative and -positive individuals. There was a direc
Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection.: Unique Identifier : AIDSLINE MED/20025999; Kropf P; Schopf LR; Chung CL; Xu D; Liew FY; Sypek JP; Muller I; In this study we characterized Th2 responses in the absence of IL-4. We show that ST2L, a stable Th2 marker, is expressed at similar levels in Leishmania major-infected IL-4-deficient
Selective pressure exerted by immunodominant HIV-1-specific cytotoxic T lymphocyte responses during primary infection drives genetic variation restricted to the cognate epitope.: Eur J Immunol. 1999 Nov;29(11):3629-35. Unique Identifier : AIDSLINE MED/20026000; Soudeyns H; Paolucci S; Chappey C; Daucher MB; Graziosi C; Vaccarezza M; Cohen OJ; Fauci AS; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Department of Internal; Medicine,Centre hospitalier universitaire vaudois, Lausanne,; Switzerland.; HIV-specific cytotoxic T lymphocytes (CTL) play a central role in the control of HIV-1 replication during primary infection. It has been hypothesized that the appearance of CTL escape mutants represents an important mechanism by which HIV-1 escapes the host cell-mediated immune response. However, evidences for a direc
Dual role of TNF-alpha in NK/LAK cell-mediated lysis of chronically HIV-infected U1 cells. Concomitant enhancement of HIV expression and sensitization of cell-mediated lysis.: Eur J Immunol. 1999 Nov;29(11):3654-62. Unique Identifier : AIDSLINE MED/20026003; Fortis C; Biswas P; Soldini L; Veglia F; Careddu AM; Delfanti F; Mantelli B; Murone M; Lazzarin A; Poli G; Laboratory of Clinical Immunology, Division of Infectious; Diseases, Centro San Luigi, San Raffaele Scientific Institute,; Milano, Italy. fortis.claudio@hsr.it; The U937-derived chronically HIV-infected U1 cell line and uninfected U937 cell clones were efficiently lysed by both unstimulated (NK) and IL-2-stimulated (lymphokine-activated killer; LAK) peripheral blood mononuclear cells (PBMC) of healthy HIV-seronegative donors. Pretreatment of target cells with IFN-gamma down-m
Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in a virus infection.: Eur J Immunol. 1999 Nov;29(11):3674-82. Unique Identifier : AIDSLINE MED/20026005; Gangappa S; Deshpande SP; Rouse BT; Department of Microbiology, College of Veterinary Medicine, The; University of Tennessee, Knoxville, USA.; Herpetic stromal keratitis (HSK) is an immunopathological lesion involving herpes simplex virus (HSV) infection and CD4(+) T cells of the Th1 phenotype, but the nature of the target antigens which drive HSK remains uncertain. In the present report we show that ovalbumin TCR-transgenic mice backcrossed to SCID mice una
IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection.: Unique Identifier : AIDSLINE MED/20026017; Wang S; Fan Y; Brunham RC; Yang X; Delayed-type hypersensitivity (DTH) has been demonstrated to be a Th1 type immune response which is important in the host defense against infection with intracellular bacteria, including Chlamydia. In the present study, we surprisingly observed that C. trachomatis mouse pneumonitis MoPn-infected IFN-gamma gene knockou
Protection against lethal toxoplasmosis in mice by an avirulent strain of Toxoplasma gondii: stimulation of IFN-gamma and TNF-alpha response.: Exp Parasitol. 1999 Dec;93(4):231-40. Unique Identifier : AIDSLINE MED/20070974; Haque S; Franck J; Dumon H; Kasper LH; Haque A; Department of Medicine and Microbiology, Dartmouth Medical School; Hanover, New Hampshire, 03755, USA. s.haque@medecine.univ-mrs.fr; In this study, we examined whether the PTN strain (isolated from an AIDS patient) of Toxoplasma gondii could induce cross-protection in mice against infection with a lethal dose of the PLK strain. Mice were first infected with tachyzoites (5 x 10(5)) of PTN and 5 days later challenged with PLK (1 x 10(5), LD(90)) para
Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides.: Unique Identifier : AIDSLINE MED/20036432; Hosoya T; Takeuchi H; Kanesaka Y; Yamakawa H; Miyano-Kurosaki N; Takai K; Yamamoto N; Takaku H; The inhibition of specific transcription regulatory proteins is a new approach to control gene expression. The transcriptional activities of DNA-binding proteins can be inhibited by the use of double-stranded oligonucleotides that compete for the binding to
National probability samples in studies of low-prevalence diseases. Part I: Perspectives and lessons from the HIV cost and services utilization study.: Health Serv Res. 1999 Dec;34(5 Pt 1):951-68. Unique Identifier : AIDSLINE MED/20057224; Shapiro MF; Berk ML; Berry SH; Emmons CA; Athey LA; Hsia DC; Leibowitz AA; Maida CA; Marcus M; Perlman JF; Schur CL; Schuster MA; Senterfitt JW; Bozzette SA; Department of Medicine, The University of California, Los; Angeles, USA.; OBJECTIVE: To examine the trade-offs inherent in selecting a sample design for a national study of care for an uncommon disease, and the adaptations, opportunities and costs associated with the choice of national probability sampling in a study of HIV/AIDS. SETTING: A consortium of public and private funders, research
National probability samples in studies of low-prevalence diseases. Part II: Designing and implementing the HIV cost and services utilization study sample.: Health Serv Res. 1999 Dec;34(5 Pt 1):969-92. Unique Identifier : AIDSLINE MED/20057225; Frankel MR; Shapiro MF; Duan N; Morton SC; Berry SH; Brown JA; Burnam MA; Cohn SE; Goldman DP; McCaffrey DF; Smith SM; St. Clair PA; Tebow JF; Bozzette SA; Baruch College, CUNY, USA.; OBJECTIVE: The design and implementation of a nationally representative probability sample of persons with a low-prevalence disease, HIV/AIDS. DATA SOURCES/STUDY SETTING: One of the most significant roadblocks to the generalizability of primary data collected about persons with a low-prevalence disease is the lack of
Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells.: J Biol Chem. 1999 Nov 26;274(48):33881-7. Unique Identifier : AIDSLINE MED/20036519; De Bleser PJ; Xu G; Rombouts K; Rogiers V; Geerts A; Laboratory for Cell Biology, Free University Brussels, B-1090; Brussels, Belgium.; Reactive oxygen species are implicated in the pathogenesis of several diseases, including Alzheimer s disease, multiple sclerosis, human immunodeficiency virus, and liver fibrosis. With respect to liver fibrosis, we have investigated differences in antioxidant enzymes expression in stellate cells (SCs) and parenchymal
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.: J Biol Chem. 1999 Nov 26;274(48):33913-20. Unique Identifier : AIDSLINE MED/20036523; Zhong M; Munzer JS; Basak A; Benjannet S; Mowla SJ; Decroly E; Chretien M; Seidah NG; Laboratory of Biochemical, Clinical Research Institute of; Montreal, University of Montreal, Montreal, Quebec H2W 1R7.; All proprotein convertases (PCs) of the subtilisin/kexin family contain an N-terminal prosegment that is presumed to act both as an intramolecular chaperone and an inhibitor of its parent enzyme. In this work, we examined inhibition by purified, recombinant bacterial prosegments of furin and PC7 on the in vitro proces
Self-association and domains of interactions of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by analytical ultracentrifugation and NMR experiments in trifluoroethanol/H(2)O mixtures.: Unique Identifier : AIDSLINE MED/20036559 P; Maroun RG
Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA.: J Biol Chem. 1999 Nov 26;274(48):34226-32. Unique Identifier : AIDSLINE MED/20036565; Kimzey AL; Dynan WS; Gene Regulation Program, Institute of Molecular Medicine and; Genetics, Medical College of Georgia, Augusta, Georgia 30912,; USA.; The human T-cell leukemia virus Tax protein directs binding of a host factor, cAMP response element binding protein, to an extended recognition sequence in the proviral promoter. Prior cross-linking experiments have revealed that Tax makes restricted contact with this DNA at two symmetric positions, 14 nucleotides apa
Functional disparity of distinct CD28 response elements toward mitogenic responses.: J Biol Chem. 1999 Nov 26;274(48):34369-74. Unique Identifier : AIDSLINE MED/20036584; Civil A; Rensink I; Aarden LA; Verweij CL; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Department of Autoimmune Diseases, 1066 CX Amsterdam,; The Netherlands.; Activation of T cells through the antigen-specific T-cell receptor in combination with a costimulatory signal results in efficient cytokine gene transcription. The CD28-induced signal represents a major costimulatory signal for T cells. A CD28 response element, named CD28RE, was first identified in the interleukin-2 (
The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.: J Biol Chem. 1999 Nov 26;274(48):34417-24. Unique Identifier : AIDSLINE MED/20036591; Li XH; Murphy KM; Palka KT; Surabhi RM; Gaynor RB; Division of Hematology-Oncology, Department of Medicine, Simmons; Cancer Center, University of Texas Southwestern Medical Center,; Dallas, Texas 75235-8594, USA.; Two cytokine-inducible kinases, IKKalpha and IKKbeta, are components of a 700-kDa kinase complex that specifically phosphorylates IkappaB. Phosphorylation of IkappaB by IKK leads to its ubiquitination and subsequent degradation, resulting in the nuclear translocation of NF-kappaB. The oncogenic protein Tax, encoded by
Enhancement of antibody responses by DNA immunization using expression vectors mediating efficient antigen secretion.: J Immunol Methods. 1999 Aug 31;228(1-2):121-30. Unique Identifier : AIDSLINE MED/20027004; Svanholm C; Bandholtz L; Lobell A; Wigzell H; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Box 280, 171 77, Stockholm, Sweden. cecilia.svanholm@mtc.ki.se; The immune responses elicited in mice, after intradermal (i.d.) immunization with plasmids encoding secreted or intracellular forms of HIV-1 nef, HIV-1 tat or C. pneumoniae omp2 proteins, respectively, were compared. To mediate secretion of these proteins the genes were fused to a heterologous signal sequence from mur
Generation and maintenance of autoantigen-specific CD8(+) T cell clones isolated from NOD mice.: J Immunol Methods. 1999 Aug 31;228(1-2):87-95. Unique Identifier : AIDSLINE MED/20027001; Bowie L; Tite J; Cooke A; Department of Medicine, Institute of Medical Sciences, University; of Aberdeen, Foresterhill, Aberdeen, UK. l.bowie@abdn.ac.uk; The non-obese diabetic (NOD) mouse develops insulin dependent diabetes mellitus (IDDM) spontaneously with a higher incidence in females than in males. There are many similarities to the human disease, making it an ideal model. Our group is examining the role that CD4(+) and CD8(+) T cells play in IDDM in the NOD mouse
Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1.: J Neurochem. 1999 Dec;73(6):2348-57. Unique Identifier : AIDSLINE MED/20047418; Bajetto A; Bonavia R; Barbero S; Piccioli P; Costa A; Florio T; Schettini G; Neuroscience Unit, Advanced Biotechnology Centre, Genova, Italy.; Chemokines are a family of proteins that chemoattract and activate cells by interacting with specific receptors on the surface of their targets. The chemokine stromal cell-derived factor 1, (SDF1), binds to the seven-transmembrane G protein-coupled CXCR4 receptor and acts to modulate cell migration, differentiation, a
Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: frequency and clinical significance.: J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):789-92. Unique Identifier : AIDSLINE MED/20036732; Bossolasco S; Marenzi R; Dahl H; Vago L; Terreni MR; Broccolo F; Lazzarin A; Linde A; Cinque P; Division of Infectious Diseases, San Raffaele Hospital, Via; Stamira d'Ancona 20, 20127 Milano, Italy.; The objective was to evaluate the frequency of human herpesvirus 6 (HHV-6) DNA detection in the CSF of patients infected with HIV and its relation to brain disease and systemic HHV-6 infection. Nested polymerase chain reaction (PCR) was used to analyse CSF samples from 365 consecutive HIV infected patients with neurol
The Outpatient Developmental Services Project: integration of pediatric psychology with primary medical care for children infected with HIV.: J Pediatr Psychol. 1999 Oct;24(5):381-91. Unique Identifier : AIDSLINE MED/20022101; Armstrong FD; Harris LL; Thompson W; Semrad JL; Jensen MM; Lee DY; Miloslavich K; Garcia A; University of Miami School of Medicine, USA.; darmstro@peds.med.miami.edu; OBJECTIVE: To present a model in which pediatric psychology services are programmatically integrated into the primary care of children seen in a special immunology program. The program centers around serial neurodevelopmental/neuropsychological evaluation of children infected with HIV. METHOD: We describe the populati
A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes.: J Mol Cell Cardiol. 1999 Nov;31(11):2037-47. Unique Identifier : AIDSLINE MED/20058559; Sakoda T; Kasahara N; Hamamori Y; Kedes L; Institute for Genetic Medicine, University of Southern California; School of Medicine, Los Angeles 90033, USA.; Human immunodeficiency virus (HIV, lentivirus) type-1 based vectors have a number of attractive features for gene therapy, including the ability to transduce non-dividing cells and long term transgene expression. We used a three-plasmid expression system to generate pseudotyped lentivirus-based vectors by transient tr
AIDS in paradise.: JAMA. 1999 Dec 15;282(23):2195-6. Unique Identifier : AIDSLINE MED/20071974; Koenig RE
AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study.: JAMA. 1999 Dec 15;282(23):2220-6. Unique Identifier : AIDSLINE MED/20071989; Ledergerber B; Egger M; Erard V; Weber R; Hirschel B; Furrer H; Battegay M; Vernazza P; Bernasconi E; Opravil M; Kaufmann D; Sudre P; Francioli P; Telenti A; Division of Infectious Diseases and Hospital Epidemiology,; University Hospital, Zurich, Switzerland.; CONTEXT: Acquired immunodeficiency syndrome-related opportunistic illnesses (Ols) continue to occur after initiation of potent antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection. Risk factors for clinical progression to Ols during potent therapy are not well defined. OBJECTIVE: To exa
Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial [see comments]: JAMA. 1999 Dec 22-29;282(24):2305-12. Unique Identifier : AIDSLINE MED/20077564; Kahn J; Lagakos S; Wulfsohn M; Cherng D; Miller M; Cherrington J; Hardy D; Beall G; Cooper R; Murphy R; Basgoz N; Ng E; Deeks S; Winslow D; Toole JJ; Coakley D; Positive Health Program University of California San Francisco,; San Francisco General Hospital, 94110, USA. jkahn@php.ucsf.edu; CONTEXT: Adefovir dipivoxil is a nucleotide analog that has demonstrated effective antiretroviral activity against human immunodeficiency virus (HIV) with once-daily administration. OBJECTIVE: To determine if adefovir confers antiretroviral or immunologic benefit when added to stable antiretroviral therapy. DESIGN: Mu
Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology.: JAMA. 1999 Dec 22-29;282(24):2321-7. Unique Identifier : AIDSLINE MED/20077566; Bifani PJ; Mathema B; Liu Z; Moghazeh SL; Shopsin B; Tempalski B; Driscol J; Frothingham R; Musser JM; Alcabes P; Kreiswirth BN; Public Health Research Institute Tuberculosis Center, Department; of Microbiology, New York University School of Medicine, NY; 10016, USA.; CONTEXT: Typing of Mycobacterium tuberculosis could provide a more sensitive means of identifying outbreaks than use of conventional surveillance techniques alone. Variants of the New York City W strain of M tuberculosis were identified in New Jersey. OBJECTIVE: To describe the spread of the W family of M tuberculosis
Adefovir for the treatment of HIV infection: if not now, when? [editorial; comment]: Unique Identifier : AIDSLINE MED/20077572; Mellors JW
Clinical course of HTLV-I-associated uveitis.: Unique Identifier : AIDSLINE MED/20046630; Nakao K; Ohba N; Nakagawa M; Osame M; PURPOSE: To define the long-term clinical course and visual outcome of human T-cell lymphotrophic virus type I (HTLV-I)-associated uveitis (HAU). METHODS: We reviewed the clinical data on 96 eyes of 70 patients, 26 men and 44 women, with HAU, with specific reference to recurrence of the disease and long-term visual ou
Antiviral agents for non-human immunodeficiency virus infections.: Mayo Clin Proc. 1999 Dec;74(12):1266-83. Unique Identifier : AIDSLINE MED/20058930; Keating MR; Division of Infectious Diseases and Internal Medicine, Mayo; Clinic Rochester, Minnesota 55905, USA.; Several new agents for treating viral infections have been developed in recent years. All available agents are virustatic, inhibiting specific steps in the process of viral replication. No agent is active against nonreplicating or latent viruses. Acyclovir is useful in the treat
Antiretrovirals.: Mayo Clin Proc. 1999 Dec;74(12):1284-301. Unique Identifier : AIDSLINE MED/20058931; Temesgen Z; Wright AJ; Mayo HIV Clinic, Division of Infectious Diseases and Internal; Medicine, Mayo Clinic Rochester, Minnesota, USA.; Deaths related to the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome and the incidence of opportunistic infections have been drastically decreased in the industrialized world. These reductions are mainly due to recent advances in the management of HIV infection, including the availabilit
Intestinal parasites of some diarrhoeic HIV-seropositive individuals in North Brazil, with particular reference to Isospora belli Wenyon, 1923 and Dientamoeba fragilis Jepps & Dobell, 1918.: Mem Inst Oswaldo Cruz. 1999 Sep-Oct;94(5):611-3. Unique Identifier : AIDSLINE MED/99395230; Lainson R; da Silva BA; Secao de Parasitologia, Instituto Evandro Chagas, Belem, PA,; 66090-000, Brasil.
Plasma platelet-activating factor acetylhydrolase activity in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.: Metabolism. 1999 Dec;48(12):1524-31. Unique Identifier : AIDSLINE MED/20066966; Khovidhunkit W; Memon RA; Shigenaga JK; Pang M; Schambelan M; Mulligan K; Feingold KR; Grunfeld C; Department of Veterans Affairs Medical Center, San Francisco, CA; 94121, USA.; Platelet-activating factor (PAF) acetylhydrolase (PAF-AH) catalyzes the hydrolysis of PAF, a mediator of inflammation, as well as other biologically active oxidized phospholipids. In humans, plasma PAF-AH activity is bound to low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Higher levels of plasma PAF
[Role of chorionic gonadotropin in the differentiation of thymocytes]: Ontogenez. 1999 Sep-Oct;30(5):341-5. Unique Identifier : AIDSLINE MED/20048307; Kuklina EM; Shirshev SV; Sharova NI; Iarilin AA; Institute of Ecology and Genetics of Microorganisms, Ural Branch; of the Russian Academy of Sciences, Perm, Russia.; The effects of chorionic gonadotropin, a basic hormone of pregnancy, on the differentiation of the human thymocytes were studied. The hormone does not affect the phenotype as determined by expression of the membrane molecules CD3, CD4, CD8 and functional activity of intrathymic pre-T-lymphocytes, but stimulates produc
Characterization of murine Th1 clones specific to egg antigen of Schistosoma japonicum and their interaction with cytokines.: Parasite Immunol. 1999 Nov;21(11):583-93. Unique Identifier : AIDSLINE MED/20051371; Yang JQ; Tasaka K; Chuang CK; Yoshikawa H; Nakajima Y; Department of Parasitology and Immunology, Yamanashi Medical; University, Tamaho, Yamanashi 409-3898, Japan.; T cell clones (B1, B21, B7, A25) specific to the soluble egg antigen (SEA) of Schistosoma japonicum were established from C3H/He mice immunized with SEA. These clones belonged to CD3+, CD4+ and CD8-Th1 cells, showing TCR-gamma delta-, TCR-alpha beta+ and Vbeta10b+. The molecular weights of target antigens recognized b
The distribution of RNA motifs in natural sequences.: Nucleic Acids Res. 1999 Nov 15;27(22):4457-67. Unique Identifier : AIDSLINE MED/20007891; Bourdeau V; Ferbeyre G; Pageau M; Paquin B; Cedergren R; Departement de Biochimie, Universite de Montreal, C.P. 6128,; Succursale Centre-Ville, Montreal, QC H3C 3J7, Canada.; Functional analysis of genome sequences has largely ignored RNA genes and their structures. We introduce here the notion of ribonomics to describe the search for the distribution of and eventually the determination of the physiological roles of these RNA structures found in the sequence databases. The utility of thi
Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia.: Planta Med. 1999 Oct;65(7):604-9. Unique Identifier : AIDSLINE MED/20042628; Berge JP; Bourgougnon N; Alban S; Pojer F; Billaudel S; Chermann JC; Robert JM; Franz G; Laboratoire de Biochimie et molecules Marines, IFREMER, Nantes,; France.; A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50% inhibitory concentration (EC50) of 14 micrograms/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation
The natural history of type 2 diabetes. Implications for clinical practice.: Prim Care. 1999 Dec;26(4):771-89. Unique Identifier : AIDSLINE MED/99453076; Ramlo-Halsted BA; Edelman SV; Division of Endocrinology and Metabolism, University of; California, San Diego, San Diego, California, USA.; This article reviews the natural history of type 2 diabetes and emphasizes that the disease is a continuum from impaired glucose tolerance and impaired fasting glucose to frank diabetes. Understanding this natural history aids the clinician in identifying those individuals most at risk for developing type 2 diabetes.
[The prattle with respect to the acquired immunodeficiency syndrome (letter; comment)]: Rev Clin Esp. 1999 Oct;199(10):695-6. Unique Identifier : AIDSLINE MED/20056641; Munoz Sanz A
[Chemokines, a new family of cytokines in inflammatory cell recruitment]: Rev Invest Clin. 1999 Jul-Aug;51(4):255-68. Unique Identifier : AIDSLINE MED/20013830; Martinez Martinez CM; Hernandez Pando R; Departamento de Patologia, Instituto Nacional de la Nutricion; Salvador Zubiran, Mexico, D.F.; Cell recruitment is a crucial event in the establishment of both acute and chronic inflammatory responses, including acute and delayed type hypersensitivity reactions. Among other significant factors like adhesion molecules, chemokines and its receptors are crucial elements that lead leukocyte migration to the tissues
Randomization-based methods for correcting for treatment changes: examples from the Concorde trial.: Stat Med. 1999 Oct 15;18(19):2617-34. Unique Identifier : AIDSLINE MED/99426978; White IR; Babiker AG; Walker S; Darbyshire JH; Medical Statistics Unit, London School of Hygiene and Tropical; Medicine, Keppel Street, London WC1E 7HT, U.K.; We develop analysis methods for clinical trials with time-to-event outcomes which correct for treatment changes during follow-up, yet are based on comparisons of randomized groups and not of selected groups. A causal model relating observed event times to event times that would have been observed under other treatment
Bayesian analysis of prevalence with covariates using simulation-based techniques: applications to HIV screening.: Stat Med. 1999 Nov 30;18(22):3059-73. Unique Identifier : AIDSLINE MED/20013163; Tu XM; Kowalski J; Jia G; Department of Biostatistics and Epidemiology, University of; Pennsylvania School of Medicine, 604 Blockley Hall, 423 Guardian; Drive, Philadelphia, PA 19104-6021, USA.; Ignoring the limited precision of medical diagnostic tests can incur serious bias in prevalence estimation. Conversely, treating the values of sensitivity and specificity as constants, as in most studies, inevitably underestimates the variability of prevalence estimates. Bayesian inference provides a natural framework
A non-parametric maximum likelihood estimator for bivariate interval censored data.: Stat Med. 1999 Nov 30;18(22):3089-100. Unique Identifier : AIDSLINE MED/20013165; Betensky RA; Finkelstein DM; Department of Biostatistics, Harvard School of Public Health, 655; Huntington Avenue, Boston, Massachusetts 02115, USA.; betensky@hsph.harvard.edu; We derive a non-parametric maximum likelihood estimator for bivariate interval censored data using standard techniques for constrained convex optimization. Our approach extends those taken for univariate interval censored data. We illustrate the estimator with bivariate data from an AIDS study. Copyright 1999 John Wil
An extension of Kendall's coefficient of concordance to bivariate interval censored data.: Stat Med. 1999 Nov 30;18(22):3101-9. Unique Identifier : AIDSLINE MED/20013166; Betensky RA; Finkelstein DM; Department of Biostatistics, Harvard School of Public Health, 655; Huntington Avenue, Boston, Massachusetts 02115, USA.; betensky@hsph.harvard.edu; Non-parametric tests of independence, as well as accompanying measures of association, are essential tools for the analysis of bivariate data. Such tests and measures have been developed for uncensored and right censored failure time data, but have not been developed for interval censored failure time data. Bivariate
The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo.: Science. 1999 Dec 10;286(5447):2159-62. Unique Identifier : AIDSLINE MED/20059937; Randolph DA; Huang G; Carruthers CJ; Bromley LE; Chaplin DD; Division of Allergy and Immunology, Department of Internal; Medicine, Center for Immunology, Washington University School of; Medicine. Howard Hughes Medical Institute, St. Louis, MO 63110,; USA.; Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naive and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones ne
Where do we stand with 5-fluorouracil?: Semin Oncol. 1999 Dec;26(6):589-605. Unique Identifier : AIDSLINE MED/20072268; Schmoll HJ; Buchele T; Grothey A; Dempke W; Department of Hematology/Oncology, Martin-Luther-University; Halle-Wittenberg, Halle, Germany.; For nearly four decades, 5-fluorouracil (5-FU) has been the mainstay of treatment for colorectal cancer. Due to the lack of other agents with significant activity, tremendous efforts have been undertaken to increase the efficacy of 5-FU by investigating alternative schedules of delivery and biomodulation. However, bol
Challenged by the small screen--responding to HIV-positive people on video in KwaZulu-Natal.: S Afr Med J. 1999 Oct;89(10):1060-6. Unique Identifier : AIDSLINE MED/20048758; Coleman R; Mngomezulu P
A quick, simple, and inexpensive method of surgical navigation for superficial intracranial targets.: Surg Neurol. 1999 Nov;52(5):530-1. Unique Identifier : AIDSLINE MED/20061224; Amar AP; Levy ML; Weiss MH; Department of Neurosurgery, University of Southern California,; Los Angeles, USA.
[HIV infection, gonorrhea and syphilis from Thailand to Norway]: Tidsskr Nor Laegeforen. 1999 Oct 30;119(26):3915-8. Unique Identifier : AIDSLINE MED/20060337; Aavitsland P; Nilsen O; Seksjon for forebyggende infeksjonsmedisin Statens institutt for; folkehelse, Oslo.; Thailand , a popular tourist destination for Norwegians, is experiencing an increasing epidemic of HIV infection. We used the Norwegian surveillance system for communicable diseases to assess the connections between the Norwegian and Thai epidemics. Before 1999, 1,869 cases of HIV
HIV-1 DNA vaccines and chemokines.: Vaccine. 1999 Oct 1;17 Suppl 2:S53-64. Unique Identifier : AIDSLINE MED/99436492; Boyer JD; Kim J; Ugen K; Cohen AD; Ahn L; Schumann K; Lacy K; Bagarazzi ML; Javadian A; Ciccarelli RB; Ginsberg RS; MacGregor RR; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.; DNA vaccines have a demonstrated ability to induce humoral and cellular immune responses in animal models and humans. The technology, although it dates back to the 1950 s, has had an insurgence of interest within the past few years following concurrent research papers. The basic technology is being applied broadly to
AIDS and HIV vaccines.: Vaccine. 1999 Oct 1;17 Suppl 2:S65-70. Unique Identifier : AIDSLINE MED/99436493; Klein M; Pasteur Merieux Connaught, 1541 Avenue Marcel Merieux, 69280,; Marcy l'Etoile, France.; In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite
Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidate.: Vaccine. 1999 Sep;18(3-4):259-67. Unique Identifier : AIDSLINE MED/99438260; Klinguer C; David D; Kouach M; Wieruszeski JM; Tartar A; Marzin D; Levy JP; Gras-Masse H; UMR 8525, IBL, Institut Pasteur de Lille, 1 rue Calmette, 59021,; Lille, France.; A multi-component vaccine has been defined, which contains six different synthetic 24- to 32-amino acid lipopeptides derived from the sequence of HIV-1 proteins. The physicochemical properties of the lipopeptide components were compatible with multi-dimensional analysis, using RP-HPLC, Edman sequencing, electrospray m
Accelerated clearance of SHIV in rhesus monkeys by virus-like particle vaccines is dependent on induction of neutralizing antibodies.: Vaccine. 1999 Sep;18(3-4):291-301. Unique Identifier : AIDSLINE MED/99438264; Notka F; Stahl-Hennig C; Dittmer U; Wolf H; Wagner R; Institute of Medical Microbiology, University of Regensburg,; Franz-Josef-Strauss Allee 11, D-93053, Regensburg, Germany.; Recombinant, insect cell derived SIV Pr56(gag) virus-like particles (VLPs) have been modified either by inserting HIV-1 Gp160 derived peptides into the Pr56(gag) precursor or by integrating the complete HIV-1 gp120 in the particle membrane. To investigate the protective efficacy of these particulate antigens, rhesus m
Specificity of anti-Nef antibodies produced in mice immunized with DNA encoding the HIV-1 nef gene product.: Vaccine. 1999 Sep;18(3-4):333-41. Unique Identifier : AIDSLINE MED/99438270; Moureau C; Moynier M; Kavsan V; Montagnier L; Bahraoui E; Laboratoire d'Immuno-virologie, Universite Paul Sabatier, 118; route de Narbonne, 31062, Toulouse, France.; Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo
Mapping the specificity of an anti-feline immunodeficiency virus monoclonal antibody using a filamentous phage displayed peptide library.: Vaccine. 1999 Sep;18(3-4):371-5. Unique Identifier : AIDSLINE MED/99438274; D'Mello F; Kairo SK; Howard CR; Partidos CD; Department of Pathology and Infectious Diseases, Royal Veterinary; College, Royal College Street, London, UK.; Recent developments in peptide technology enable the use of random peptide libraries for identifying linear amino acid sequences (mimotopes) which can mimic conformational epitopes without necessarily exhibiting amino acid sequence homology with the native linear sequence. In this study a 15-mer random peptide library
New developments in antiretroviral treatment.: Am Fam Physician. 1999 Dec;60(9):2663, 2666. Unique Identifier : AIDSLINE MED/20072013; Sadovsky R
Maternal HIV levels correlate with perinatal transmission.: Am Fam Physician. 1999 Dec;60(9):2684, 2687. Unique Identifier : AIDSLINE MED/20072014; Kirchner JT
The Village AIDS Day Treatment Program: a model of interdisciplinary and interdependent care.: Am J Occup Ther. 1999 Nov-Dec;53(6):561-5. Unique Identifier : AIDSLINE MED/20045385; Murphy N; Messina W; Getter E; Gutterman L; Martin T; Rincon P; Zimmerman J; Village AIDS Day Treatment Program, New York, New York 10011,; USA.; This article describes the Village AIDS Day Treatment Program, a program for people living with HIV/AIDS that provides health care by using a full range of interdependent services. Opened in 1988, this program was the first of its kind in the country. It has provided leadership in developing a model of care that addre
Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis.: Am J Pathol. 1999 Dec;155(6):1915-27. Unique Identifier : AIDSLINE MED/20063638; Dallasta LM; Pisarov LA; Esplen JE; Werley JV; Moses AV; Nelson JA; Achim CL; Department of Pathology, Division of Neuropathology, University; of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; dallasta@np.awing.upmc.edu; The blood-brain barrier (BBB) plays a critical role in regulating cell trafficking through the central nervous system (CNS) due to several unique anatomical features, including the presence of interendothelial tight junctions that form impermeable seals between the cells. Previous studies have demonstrated BBB perturb
Sexual and drug-use risk factors for HIV and STDs: a comparison of women with and without bisexual experiences.: Am J Public Health. 1999 Dec;89(12):1841-6. Unique Identifier : AIDSLINE MED/20056691; Gonzales V; Washienko KM; Krone MR; Chapman LI; Arredondo EM; Huckeba HJ; Downer A; Center for Health Education and Research, University of; Washington, Seattle 98104, USA. gonza@u.washington.edu; OBJECTIVES: This study was done to compare risk factors for HIV/STDs in women who reported having had sex with both men and women and women who reported having had sex with men only. METHODS: Female participants in a multisite, randomized HIV/STD prevention study in the Seattle area reported both having had sex with a
Cigarette smoking among gay and bisexual men.: Am J Public Health. 1999 Dec;89(12):1875-8. Unique Identifier : AIDSLINE MED/20056701; Stall RD; Greenwood GL; Acree M; Paul J; Coates TJ; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA. rstall@psg.ucsf.edu; OBJECTIVES: This study measured the prevalence of cigarette smoking among gay men and identified associations with smoking. METHODS: Household-based (n = 696) and bar-based (n = 1897) sampling procedures yielded 2593 gay male participants from Portland, Ore, and Tucson, Ariz, in the spring of 1992. RESULTS: Forty-eigh
Detection of DNA hybridization using the TISPR-1 surface plasmon resonance biosensor.: Anal Biochem. 1999 Oct 1;274(1):7-17. Unique Identifier : AIDSLINE MED/99459221; Kukanskis K; Elkind J; Melendez J; Murphy T; Miller G; Garner H; Joint Program of Biomedical Engineering, University of Texas; Southwestern Medical Center at Dallas, Dallas, Texas, USA.; Biotinylated oligonucleotide probes were immobilized to the gold sensor surface of the TISPR-1 miniature integrated surface plasmon resonance liquid sensor system for the purpose of detecting specific DNA hybridization. The immobilization of the oligonucleotide capture probes was carried out through streptavidin-bioti
The synthetic CD4 exocyclic CDR3.AME(82-89) inhibits NF-kappaB nuclear translocation, HIV-1 promoter activation, and viral gene expression.: DNA Cell Biol. 1999 Nov;18(11):819-28. Unique Identifier : AIDSLINE MED/20060844; Roland J; Berezov A; Greene MI; Murali R; Piatier-Tonneau D; Devaux C; Briant L; Laboratoire Infections Retrovirales et Signalisation Cellulaire,; CNRS EP J0004, Institut de Biologie, Montpellier, France.; We have previously shown that the synthetic aromatically modified exocyclic (AME) analog (CDR3.AME(82-89), derived from the CDR3 (residues 82-89) region of CD4 domain 1, inhibits replication of human immunodeficiency virus type 1 (HIV-1) in infected cells. In this work, we investigated the mechanism by which this inhi
Nurses with blood-borne pathogens and the moral responsibilities of nurse regulating authorities.: Aust J Adv Nurs. 1999 Mar-May;16(3):7-13. Unique Identifier : AIDSLINE MED/99354720; Johnstone MJ; Crock E; Department of Nursing and Public Health, Faculty of Biomedical; and Health Sciences and Nursing, RMIT University, Victoria,; Australia.; This paper examines, for consideration by nurses and nurse regulating authorities (NRA), certain ethical and practice issues concerning registered/enrolled nurses with blood-borne pathogens (BBPs), such as Human Immunodeficiency Virus and Hepatitis Viruses. Under existing legislation, the identity and infectious statu
Interleukin-10: The missing link in asthma regulation? [comment]: Am J Respir Cell Mol Biol. 1999 Nov;21(5):562-3. Unique Identifier : AIDSLINE MED/20007693; Umetsu DT; DeKruyff RH; Department of Pediatrics, Center for Asthma and Allergic; Diseases, and Stanford University, Stanford, California; 34305-5208, USA.
HIV complicates the management of oncological emergencies: a case involving the superior vena cava syndrome.: Clin Oncol (R Coll Radiol). 1999;11(5):355-7. Unique Identifier : AIDSLINE MED/20059414; Videtic GM; Kocha WI; Malthaner RA; London Regional Cancer Centre, University of Western Ontario,; London, Ontario, Canada. gvidetic@lrcc.on.ca; An association exists between human immunodeficiency virus (HIV) and an increased incidence of lung cancer. Superior vena cava syndrome (SVCS) is an oncological emergency seen in the presence of chest tumours. We report on an otherwise well HIV-positive male who presented with SVCS due to lung cancer. He was commenced
Socio-demographic characteristics and sexual behaviour of adolescents attending the STC, UCH, Ibadan: a 5 year review.: West Afr J Med. 1999 Jul-Sep;18(3):165-9. Unique Identifier : AIDSLINE MED/20060735; Fawole OI; Ajayi IO; Babalola TD; Oni AA; Asuzu MC; Department of Preventive and Social Medicine, University College; Hospital, Ibadan, Nigeria.; As a continuation of the on-going efforts to prevent and control the spread of sexually transmitted diseases (STDs) and the Acquired Immunodeficiency Syndrome (AIDS) in adolescents, this retrospective clinic-based study identifies the socio- demographic characteristics, describes the sexual practices, identifies the c
Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress [see comments]: Br J Nutr. 1999 May;81(5):405-11. Unique Identifier : AIDSLINE MED/20082075; Malpuech-Brugere C; Nowacki W; Gueux E; Kuryszko J; Rock E; Rayssiguier Y; Mazur A; Centre de Recherche en Nutrition Humaine d'Auvergne, Unite; Maladies Metaboliques et Micronutriments, INRA,; St-Genes-Champanelle, France.; Experimental Mg deficiency leads to alterations in the immune response. Reduction of thymus weight and histological changes were previously observed in Mg-deficient rats after several weeks on a deficient diet, suggesting that functions of this immune organ may be affected by Mg deficiency. More recently, changes in t
Synthesis of biotinylated glycoconjugates and their use in a novel ELISA for direct comparison of HIV-1 Gp120 recognition of GalCer and related carbohydrate analogues.: Bioconjug Chem. 1999 Nov-Dec;10(6):1021-31. Unique Identifier : AIDSLINE MED/20031552; McReynolds KD; Hadd MJ; Gervay-Hague J; The University of Arizona, Department of Chemistry, Tucson, AZ; 85721, USA.; As part of our program directed toward the design and synthesis of high-affinity ligands for the GalCer-binding site on the HIV cell surface glycoprotein, gp120, we required a reliable method for qualitatively assessing relative binding affinities for related analogues. Due to the hydrophilic nature of these synthetic
Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases.: Hum Gene Ther. 1999 Dec 10;10(18):2961-72. Unique Identifier : AIDSLINE MED/20075748; Dow SW; Elmslie RE; Fradkin LG; Liggitt DH; Heath TD; Willson AP; Potter TA; Department of Medicine, National Jewish Medical and Research; Center, Denver, CO 80206-2761, USA. dows@njc.org; Local expression of cytokine genes by ex vivo transfection or intratumoral gene delivery can control the growth of cutaneous tumors. However, control of tumor metastases by conventional nonviral gene therapy approaches is more difficult. Intravenous injection of lipid-DNA complexes containing noncoding plasmid DNA can
Tumor necrosis factor alpha and gamma interferon are required for the development of protective immunity to secondary Corynebacterium pseudotuberculosis infection in mice.: J Vet Med Sci. 1999 Nov;61(11):1203-8. Unique Identifier : AIDSLINE MED/20059150; Lan DT; Makino S; Shirahata T; Yamada M; Nakane A; Department of Veterinary Microbiology, Obihiro University of; Agriculture and Veterinary Medicine, Hokkaido, Japan.; The production and role of endogenous cytokines during the course of secondary Corynebacterium (C.) pseudotuberculosis infection were investigated in mice. When immunized mice were challenged on day 28 after primary infection, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were found to appea
[The prevalence of infection by the hepatitis B, C and human immunodeficiency viruses in drug users]: Aten Primaria. 1999 Oct 15;24(6):368-71. Unique Identifier : AIDSLINE MED/20064026; Jimenez Fabrega X; Carballo Almeida A; Batalla Martinez C; Comin Bertran E; Cuenca Oliva AM; Ezpeleta Garcia A; Lopez Gonzalo E; Parellada Esquius N; ABS Dr. Pujol i Capsada, El Prat de Llobregat, Barcelona.; OBJECTIVE: Estimate the prevalence of the hepatitis B (HBV) infection, hepatitis C (HCV) and human immunodeficiency virus (HIV) and its coexistence in intravenous drug users, in order to start afterwards a vaccination and sanitary training programmes. PATIENTS AND METHODS: Intravenous drug users attended in a health c
Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation.: Blood. 1999 Dec 1;94(11):3847-54. Unique Identifier : AIDSLINE MED/20042219; Kawakami A; Nakashima T; Sakai H; Urayama S; Yamasaki S; Hida A; Tsuboi M; Nakamura H; Ida H; Migita K; Kawabe Y; Eguchi K; The First Department of Internal Medicine, and the Department of; Hospital Pharmacy, Nagasaki University School of Medicine, Japan.; NF-kappaB is required for prevention of apoptosis. We examined the importance of human T-cell leukemia virus-I (HTLV-I) Tax protein to stimulate NF-kappaB nuclear translocation, thus preventing apoptosis. Jurkat cells and JPX-9 cells in which the inducible Tax expression plasmid vector was stably transfected were used
Granulocyte-macrophage colony-stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome.: Blood. 1999 Dec 1;94(11):3897-905. Unique Identifier : AIDSLINE MED/20042225; Coffey MJ; Phare SM; Cinti S; Peters-Golden M; Kazanjian PH; Divisions of Pulmonary and Critical Care Medicine and Infectious; Diseases, University of Michigan Medical Center, Ann Arbor, MI; 48109-0642, USA. coffeym@umich.edu; Leukotrienes (LT) are mediators derived from the 5-lipoxygenase (5-LO) pathway, which play a role in host defense, and are synthesized by both monocytes (peripheral blood monocyte [PBM]) and neutrophils (PMN). Because 5-LO metabolism is reduced in alveolar macrophages and PMN from acquired immunodeficiency syndrome (A
Zidovudine prophylaxis and perinatal HIV-1 transmission [letter]: Acta Paediatr. 1999 Nov;88(11):1298. Unique Identifier : AIDSLINE MED/20057397; Zuccotti GV; Ferraris G; Agostoni C; Rancilio L; Ravizza M; Bucceri AM; Riva E; Marini A
Salivary gland cancer in the United States.: Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1095-100. Unique Identifier : AIDSLINE MED/20078503; Sun EC; Curtis R; Melbye M; Goedert JJ; Division of Cancer Epidemiology and Genetics, National Cancer; Institute, NIH, Rockville, Maryland 20852, USA.; The risk of salivary gland cancer (SGC) is increased in atomic bomb survivors and after radiotherapy, but other risk factors are not well established. Some studies have suggested an association of SGC with breast cancer and with exposure to various viruses or UVB radiation. Corroborating evidence of these associations
Activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells.: Leuk Lymphoma. 1999 Dec;36(1-2):15-23. Unique Identifier : AIDSLINE MED/20078607; Tanaka Y; The First Department of Internal Medicine, University of; Occupational and Environmental Health, Japan, School of Medicine,; Kitakyushu. tanaka@med.uoeh-u.ac.jp; Adult T cell leukemia (ATL) is characterized by massive infiltration of circulating ATL cells into a variety of tissues, a finding often associated with poor prognosis. Leukocyte migration from circulation into tissue depends on integrin-mediated adhesion to endothelium and integrins are tightly regulated by several s
Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve surviv