Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient.

Leuk Lymphoma. 1999 Oct;35(3-4):379-87. Unique Identifier : AIDSLINE GENBANK/AF042372
Morand P; Buisson M; Collandre H; Chanzy B; Genoulaz O; Bourgeat MJ; Pinel N; Leclercq P; Leroux D; Marechal V; Fritsch L; Ruigrok R; Seigneurin JM; Laboratoire de Virologie Medicale Moleculaire (RHAP), Grenoble,; France. Patrice.Morand@ujf-grenoble.fr

Abstract: Human Herpesvirus 8 (HHV-8) has been consistently associated with Primary Effusion Lymphoma (PEL or body-cavity-based lymphoma) but not with other lymphomas. This paper reports on an AIDS patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where HHV-8 and Epstein-Barr virus (EBV) were detected by PCR and electron microscopy. Both viruses were also detected in all the cells of a malignant cell line (BBG1) established from the patient's peripheral blood mononuclear cells. As in PEL and PEL-derived cell lines, both the tumor and the lines lacked B-antigen expression in immunological studies but were of the same B origin as shown by clonal immunoglobulin gene rearrangements. In contrast to other co-infected cell lines, BBG1 and subclones spontaneously expressed the HHV-8 lytic antigens p40, p27, p60 and the EBV transforming latent antigen EBNA2. These data suggest that the clinical and biological features of HHV-8-and EBV-associated lymphomas could be wider than has been described to date in PEL particularly with the in vivo presence of circulating malignant dually-infected cells engaged in a spontaneous HHV-8 lytic infection.

Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/PATHOLOGY/ *VIROLOGY Herpesvirus 4, Human/*ISOLATION & PURIF Herpesvirus, Kaposi Sarcoma-Associated/*ISOLATION & PURIF Human Lymphoma/ETIOLOGY/*VIROLOGY Lymphoma, B-Cell/ETIOLOGY/*VIROLOGY Molecular Sequence Data Skin Neoplasms/ETIOLOGY/*VIROLOGY Support, Non-U.S. Gov't Tumor Cells, Cultured

KWDjournalarticleacquiredimmunodeficiencysyndrome/blood/complications/pathology/KWDvirologyherpesvirus4,human/KWDisolation&purifherpesvirus,kaposisarcoma-associated/KWDisolation&purifhumanlymphoma/etiology/KWDvirologylymphoma,b-cell/etiology/KWDvirologymolecularsequencedataskinneoplasms/etiology/KWDvirologysupport,non-uKWDsKWDgov'ttumorcells,cultured
000630
A0061976

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