Molecular determinants of drug resistance in tuberculosis. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Molecular determinants of drug resistance in tuberculosis.

Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S4-10. Unique Identifier : AIDSLINE MED/20150850
Riska PF; Jacobs WR Jr; Alland D; State University of New York-Health Science Center at Brooklyn,; New York, USA.

Abstract: Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-based assays for the identification of drug-resistant TB. This review summarizes the recent discoveries concerning resistance to isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, amikacin, kanamycin and the quinolones.

Keywords: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Antitubercular Agents/*PHARMACOLOGY Drug Resistance, Microbial/GENETICS Genes, Bacterial/GENETICS Human Mutation Mycobacterium tuberculosis/*DRUG EFFECTS/*GENETICS Tuberculosis/DRUG THERAPY/*GENETICS Tuberculosis, Multidrug-Resistant/GENETICS

KWDjournalarticlereviewreview,tutorialantitubercularagents/KWDpharmacologydrugresistance,microbial/geneticsgenes,bacterial/geneticshumanmutationmycobacteriumtuberculosis/KWDdrugeffects/KWDgeneticstuberculosis/drugtherapy/KWDgeneticstuberculosis,multidrug-resistant/genetics
000630
A0061964

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