Blockage of HIV-1 production through inhibition of proviral DNA synthesis by N,O-didecanoyl serinal dimethylacetal. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Blockage of HIV-1 production through inhibition of proviral DNA synthesis by N,O-didecanoyl serinal dimethylacetal.

IUBMB Life. 1999 Sep;48(3):311-5. Unique Identifier : AIDSLINE MED/20155234
Takamune N; Misumi S; Furuishi K; Shoji S; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Kumamoto University, Japan.

Abstract: Six serinal derivatives were synthesized and tested for their anti-human immunodeficiency virus type-1 (HIV-1) activity against HIV-1-infected cells. Of the 6 serinal derivatives tested, only N,O-didecanoyl serinal dimethylacetal (DDSD) was found to strongly suppress progeny virus production from acute HIV-1-infected CEM cells, while not suppressing the HIV-1 p24 production from latent HIV-1-infected ACH-2 cells after stimulation with phorbol 12-myristate 13-acetate. DDSD also inhibited the synthesis of HIV-1 proviral DNA at 20-50 microM, not only 1 h but also 24 h after HIV-1 infection. Taken together, DDSD is a potent inhibitor of HIV-1 production, and may become a unique leading compound for chemotherapy of acquired immunodeficiency syndrome.

Keywords: JOURNAL ARTICLE Acetals/CHEMISTRY/*PHARMACOLOGY Anti-HIV Agents/CHEMISTRY/*PHARMACOLOGY Cell Line DNA, Viral/DRUG EFFECTS Human HIV Infections/*DRUG THERAPY HIV-1/*DRUG EFFECTS/PHYSIOLOGY Proviruses/*DRUG EFFECTS/GENETICS Serine/*ANALOGS & DERIVATIVES/CHEMISTRY/PHARMACOLOGY Support, Non-U.S. Gov't T-Lymphocytes/*VIROLOGY Virus Replication/DRUG EFFECTS

KWDjournalarticleacetals/chemistry/KWDpharmacologyanti-hivagents/chemistry/KWDpharmacologycelllinedna,viral/drugeffectshumanhivinfections/KWDdrugtherapyhiv-1/KWDdrugeffects/physiologyproviruses/KWDdrugeffects/geneticsserine/KWDanalogs&derivatives/chemistry/pharmacologysupport,non-uKWDsKWDgov'tt-lymphocytes/KWDvirologyvirusreplication/drugeffects
000630
A0061946

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