A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells.

J Immunol. 2000 Mar 15;164(6):2890-6. Unique Identifier : AIDSLINE MED/20171484
Blanas E; Davey GM; Carbone FR; Heath WR; Walter and Eliza Hall Institute of Medical Research, Melbourne,; Victoria, Australia.

Abstract: We have previously reported that feeding OVA to C57BL/6 mice can lead to a weak CTL response that is dependent on CD4+ T cell help and is capable of causing autoimmunity. In this study, we investigated the basis of the class I and class II-restricted Ag presentation required for such CTL induction. Two days after feeding OVA, Ag-specific CD4+ and CD8+ T cells were seen to proliferate in the Peyer's patches and mesenteric lymph nodes. Little proliferation was evident in other lymphoid tissues, except at high Ags doses, in which case some dividing CD4+ T cells were observed in the spleen and peripheral lymph nodes. Using chimeric mice, the APC responsible for presenting orally derived Ags was shown to be derived from the bone marrow. Examination of the Ag dose required to activate either CD4+ or CD8+ T cells indicated that a single dose of 6 mg OVA was the minimum dose that consistently stimulated either T cell subset. These data indicate that oral Ags can be transported from the gut into the gut-associated lymphoid tissue, where they are captured by a bone marrow-derived APC and presented to both CD4+ and CD8+ T cells.

Keywords: JOURNAL ARTICLE Administration, Oral Animal Antigen Presentation Antigen-Presenting Cells/*IMMUNOLOGY/METABOLISM Antigens/*ADMINISTRATION & DOSAGE/IMMUNOLOGY/*METABOLISM Bone Marrow Cells/*IMMUNOLOGY/METABOLISM CD4-Positive T-Lymphocytes/*IMMUNOLOGY/METABOLISM CD8-Positive T-Lymphocytes/*IMMUNOLOGY/METABOLISM Dose-Response Relationship, Immunologic Intestinal Mucosa/CYTOLOGY/*IMMUNOLOGY/METABOLISM Lymphocyte Transformation/IMMUNOLOGY Lymphoid Tissue/CYTOLOGY/*IMMUNOLOGY/METABOLISM Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Transgenic Ovalbumin/ADMINISTRATION & DOSAGE/IMMUNOLOGY/METABOLISM Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/IMMUNOLOGY

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