Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy.

IC USE Viral Vaccines/GENETICS/*IMMUNOLOGY/THERAPEUTIC USE J Immunol. 2000 Mar 15;164(6):3112-22. Unique Identifier : AIDSLINE MED/20171511
Narvaiza I; Mazzolini G; Barajas M; Duarte M; Zaratiegui M; Qian C; Melero I; Prieto J; Departments ofMedicine and Genetics, Facultad de Medicina,; Universidad de Navarra, Pamplona, Spain.

Keywords: JOURNAL ARTICLE Adenoviridae/GENETICS/*IMMUNOLOGY Animal Antineoplastic Agents/ADMINISTRATION & DOSAGE/*IMMUNOLOGY/ THERAPEUTIC USE Cell Line Cell-Free System/IMMUNOLOGY/VIROLOGY Chemokines, CXC/GENETICS/*IMMUNOLOGY/PHYSIOLOGY/THERAPEUTIC USE Colonic Neoplasms/IMMUNOLOGY/PATHOLOGY/THERAPY CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Defective Viruses/GENETICS/IMMUNOLOGY Dose-Response Relationship, Immunologic Drug Synergism Female Gene Transfer Genetic Vectors/CHEMICAL SYNTHESIS Growth Inhibitors/ADMINISTRATION & DOSAGE/GENETICS/IMMUNOLOGY/ THERAPEUTIC USE Human Immunotherapy, Adoptive/METHODS Injections, Intralesional Interferon Type II/*IMMUNOLOGY Interleukin-12/GENETICS/*IMMUNOLOGY Killer Cells, Natural/IMMUNOLOGY Lymphocyte Transformation Mice Mice, Inbred BALB C Mice, Nude Recombination, Genetic/IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocytes/IMMUNOLOGY Tumor Cells, Cultured Vaccines, DNA/ADMINISTRATION & DOSAGE/GENETICS/*IMMUNOLOGY/ THERAPEUTIC USE Viral Vaccines/GENETICS/*IMMUNOLOGY/THERAPEUTIC USE J Immunol. 2000 Mar 15;164(6):3112-22. Unique Identifier : AIDSLINE MED/20171511

KWDjournalarticleadenoviridae/genetics/KWDimmunologyanimalantineoplasticagents/administration&dosage/KWDimmunology/therapeuticusecelllinecell-freesystem/immunology/virologychemokines,cxc/genetics/
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A0061909

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