Screening for HIV-associated distal-symmetric polyneuropathy in CDC-classification stages 1, 2, and 3.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Screening for HIV-associated distal-symmetric polyneuropathy in CDC-classification stages 1, 2, and 3.

Acta Neurol Scand. 2000 Mar;101(3):183-7. Unique Identifier : AIDSLINE MED/20168458
Husstedt IW; Evers S; Reichelt D; Grotemeyer KH; Kammer-Suhr B; Bockenholt S; Heese C; Department of Neurology, WWU Munster, Germany.

Abstract: OBJECTIVES: A total of 670 patients were screened for distal symmetric HIV-associated polyneuropathy during CDC stages 1-3 and its correlation to immunological deterioration. MATERIAL AND METHODS: Clinical examinations of 670 patients admitted to the neurological outpatient clinic at the Department of Neurology, University of Munster. Neurophysiological investigations were performed on the sural and peroneal nerve for detection of axonal and myelin lesion. RESULTS: Clinical examination proved progressive clinical signs and symptoms indicating distal symmetric polyneuropathy from CDC 1 (32%) to CDC 3 (55%). At least one neurophysiological result was impaired in CDC 1 in 25% and in CDC 3 in 45%. Significant correlation between neurophysiological changes and CDC4(+)-cells and beta-microglobuline were detected for stage CDC 3 C. CONCLUSION: Results show stage related prevalence of distal symmetric polyneuropathy already in early stages. In late stages of HIV-infection prevalence of distal symmetric polyneuropathy seems to be directly correlated to immunodeficiency syndrome. The pathogenesis of distal symmetric polyneuropathy during HIV-infection is up to now incompletely understood, but results indicate a clear dependency between progressive immunological dysfunction and neuropathy. High active antiretroviral therapy in patients suffering from distal symmetric polyneuropathy is a main topic of future studies.

Keywords: JOURNAL ARTICLE Adult Antigens, CD/IMMUNOLOGY Blotting, Western Centers for Disease Control and Prevention (U.S.) Demyelinating Diseases/PATHOLOGY Disease Progression Electric Stimulation/METHODS Female Human HIV Antigens/IMMUNOLOGY HIV Seropositivity/*COMPLICATIONS/IMMUNOLOGY Male Neural Conduction/PHYSIOLOGY Peroneal Nerve/PATHOLOGY/PHYSIOPATHOLOGY Polyneuropathies/*DIAGNOSIS/*ETIOLOGY/IMMUNOLOGY Severity of Illness Index Sural Nerve/PATHOLOGY/PHYSIOPATHOLOGY United States

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A0061313

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