2000

Partial restoration of hair growth in the DEBR model for Alopecia areata after in vivo depletion of CD4+ T cells.: Br J Dermatol. 1999 Mar;140(3):432-7. Unique Identifier : AIDSLINE MED/99249991; McElwee KJ; Spiers EM; Oliver RF; Department of Biological Sciences, University of Dundee, Dundee,; DD1 4HN, U.K.; Alopecia areata (AA) is widely believed to be an autoimmune disease. Hair loss is associated with a peri- and intrafollicular inflammatory infiltrate of anagen hair follicles primarily composed of CD4 + and CD8 + cells. A previous investigation involved in vivo depletion of CD8 + cells in the DEBR rat model to examine
Tinea capitis in two black african adults with HIV infection.: Br J Dermatol. 1999 Apr;140(4):722-4. Unique Identifier : AIDSLINE MED/99250062; Lateur N; Andre J; De Maubeuge J; Poncin M; Song M; Department of Dermatology, CHU Saint Pierre,Free University of; Brussels, 129 Boulevard de Waterloo, 1000 Bruxelles, Belgium.; Tinea capitis is rare in adults, although a few cases have been described in HIV-infected patients. We present two cases in black African adults who were HIV positive. In one, the condition led to the diagnosis of HIV infection. It is possible that the rarity of tinea capitis in HIV-positive adults could be related to
Trichophyton tonsurans dermatophyte granuloma in an HIV-1 infected patient [letter]: Br J Dermatol. 1999 Apr;140(4):762-3. Unique Identifier : AIDSLINE MED/99250077; Hadacek BM; Nassif A; Roux A; Desplaces N; Huerre M; De Bievre C; Aerts J; Raguin G
Purified protein derivative treatment for skin lesions of adult T-cell leukaemia/lymphoma [letter]: Br J Dermatol. 1999 Apr;140(4):767-8. Unique Identifier : AIDSLINE MED/99250081; Kanekura T; Gushi A; Kanzaki T
Good or evil: CD26 and HIV infection.: J Dermatol Sci. 2000 Apr;22(3):152-60. Unique Identifier : AIDSLINE MED/20161978; Ohtsuki T; Tsuda H; Morimoto C; Department of Clinical Immunology and AIDS Research Center, The; Institute of Medical Science, The University of Tokyo, Japan.; Acquired immune deficiency syndrome (AIDS) is an incurable disease at present and so many efforts to conquer this disease are being made around the world. In studies of human immunodeficiency virus (HIV) infection and the disease progression, it has been reported that T cells expressing CD26 are preferentially infecte
HHV-6, 7 and their related diseases.: J Dermatol Sci. 2000 Apr;22(3):205-12. Unique Identifier : AIDSLINE MED/20161983; Kosuge H; Department of Dermatology, Tokyo Electric Power Hospital, Japan.; haruhiko.kosuge@psl.ap-hop-paris.fr; Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are relatively recently discovered beta-herpesvirus. They are prevalent in the human population. Primary infection of HHV-6 has been associated with exanthem subitum and febrile illness. Little information is known about the clinical characteristics of primar
Uveitis in HIV positive patients [editorial]: Br J Ophthalmol. 2000 Mar;84(3):233-5. Unique Identifier : AIDSLINE MED/20149948; Cunningham ET Jr
Development of a self-inactivating, minimal lentivirus vector based on simian immunodeficiency virus.: Unique Identifier : AIDSLINE MED/20160191; Schnell T; Foley P; Wirth M; Munch J; Uberla K; In contrast to oncoviruses, lentiviruses do not require target cell division for integration into the host genome. Lentiviral vectors can therefore expand the spectrum of target cells susceptible to retroviral gene transfer. To analyze whether vectors based on simian immunodeficiency viruses (SIVs) could be used for g
Determination of indinavir, potassium sorbate, methylparaben, and propylparaben in aqueous pediatric suspensions.: J Pharm Biomed Anal. 1999 Apr;19(5):725-35. Unique Identifier : AIDSLINE MED/20162362; Kreuz DM; Howard AL; Ip D; Department of Pharmaceutical Analysis and Control, Merck Research; Laboratories, West Point, PA 19486, USA.; A gradient, reversed phase, HPLC method was developed for simultaneous analysis of potassium sorbate, methylparaben, propylparaben, and indinavir in aqueous suspensions that contain a proprietary orange flavoring and Magnasweet sweetener enhancer (Mac
Prevention, politics, and "having sex" [editorial]: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):15-6. Unique Identifier : AIDSLINE MED/20172683; Bradley-Springer L
Exploring the complexity of sleep disturbances in persons with HIV/AIDS.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):22-9. Unique Identifier : AIDSLINE MED/20172684; Nokes KM; Chidekel JH; Kendrew J; CUNY-Hunter College, Hunter-Bellevue School of Nursing, USA.; Sleep disturbances are influenced by physiological, psychological, and environmental factors. Many persons living with HIV/AIDS manifest a variety of sleep disorders. Although completion of a brief sleep assessment can be helpful to determine the presence of a sleep problem, more in-depth investigation is necessary wh
Nurse practitioners in rural California and AIDS.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):39-42. Unique Identifier : AIDSLINE MED/20172685; Lewis CE; Miramontes H; University of California-Los Angeles, USA.; A random sample of nurse practitioners located in the 26 rural counties of California were surveyed to assess their experience with HIV-positive patients. Of those selected, 70.5% participated; of those interviewed, 65.5% had seen a patient with HIV infection in the past 12 months. Of those providing primary care, 85%
Treatment of fungal infections with ABLC in the home-care setting.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):43-52. Unique Identifier : AIDSLINE MED/20172686; Weissmann AC; Invasive fungal infections are an important cause of morbidity and mortality in HIV-infected individuals. The management of opportunistic infections in a home-care setting offers many psychological and economic advantages over hospitalization. Amphotericin B, the gold standard treatment for invasive fungal infections,
Most frequently used alternative and complementary therapies and activities by participants in the AMCOA study.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):60-73. Unique Identifier : AIDSLINE MED/20172687; Greene KB; Berger J; Reeves C; Moffat A; Standish LJ; Calabrese C; Bastyr University AIDS Research Center, USA.; This literature review examines the current state of the scientific evidence published in peer-reviewed journals indexed in MedLine for the 10 most commonly noted alternative activities reported by the first 1,016 eligible participants in the Alternative Medical Care Outcomes in AIDS study. The most frequently used ac
The relationship between social support and health in gay men with HIV/AIDS: an integrative review.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):74-86. Unique Identifier : AIDSLINE MED/20172688; Hall VP; Western Carolina University, USA.; The purpose of this article is to analyze the existing research on the relationship between social support and health in gay men with HIV/AIDS. After literature review, 24 studies that met inclusion criteria were analyzed. It was found that the research could be divided into three distinct groups: (a) those studies th
Hemophilia: a story of success--disaster and the perseverance of the human spirit. Part 1: Background and overview.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):90-3. Unique Identifier : AIDSLINE MED/20172689; Dubin CS
Science is objective; isn't it?: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):94-6. Unique Identifier : AIDSLINE MED/20172690; Sharts-Hopko NC; College of Nursing, Villanova University, PA 19085-1690, USA.
Post-exposure prophylaxis of occupational exposure to HIV infection.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):97. Unique Identifier : AIDSLINE MED/20172691
Support for vaccine development in primary HIV prevention.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):97-8. Unique Identifier : AIDSLINE MED/20172692
The impact of religion on adherence with antiretrovirals [letter]: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):99-100. Unique Identifier : AIDSLINE MED/20172693; Melbourne KM
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.: Blood. 2000 Mar 1;95(5):1680-6. Unique Identifier : AIDSLINE MED/20156002; Taylor FB Jr; Stearns-Kurosawa DJ; Kurosawa S; Ferrell G; Chang AC; Laszik Z; Kosanke S; Peer G; Esmon CT; Oklahoma Medical Research Foundation (OMRF), Oklahoma City 73104,; USA. marie.brewer@omrf.ouhsc.edu; The influence of the endothelial protein C receptor (EPCR) on the host response to Escherichia coli was studied. Animals were treated with 4 separate protocols for survival studies and analysis of physiologic and biochemical parameters: (1) monoclonal antibody (mAb) that blocks protein C/activated protein C binding to
Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality.: Blood. 2000 Mar 1;95(5):1743-51. Unique Identifier : AIDSLINE MED/20156011; Soudeyns H; Campi G; Rizzardi GP; Lenge C; Demarest JF; Tambussi G; Lazzarin A; Kaufmann D; Casorati G; Corey L; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Division of Infectious; Diseases, Department of Internal Medicine, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.; Major T-cell receptor beta chain variable region (TCRBV) repertoire perturbations are temporally associated with the down-regulation of viremia during primary human immunodeficiency virus (HIV) infection and with oligoclonal expansion and clonal exhaustion of HIV-specific cytotoxic T lymphocytes (CTLs). To determine w
Alloantigen-induced anti-HIV activity occurs prior to reverse transcription and can be generated by leukocytes from HIV-infected individuals [letter]: Blood. 2000 Mar 1;95(5):1875-6. Unique Identifier : AIDSLINE MED/20203361; Pinto LA; Blazevic V; Shearer GM; Patterson BK; Dolan MJ
Fatty acid composition of plasma lipids in HIV-infected children. Comparison with seroreverters.: Acta Paediatr. 2000 Feb;89(2):172-6. Unique Identifier : AIDSLINE MED/20173120; Agostoni C; Riva E; Esposito S; Ferraris G; Principi N; Zuccotti GV; Pediatric Department V, University of Milan, Italy.; agostoc@tin.it; Children infected with the type-1 human immunodeficiency virus (HIV) are at risk of nutritional deficiencies leading to an impaired polyunsaturated fatty acid (PUFA) status. The aim of the present study was to compare the PUFA composition of plasma lipid classes (total lipids, phospholipids (PL), cholesteryl esters (C
Intensive nursing care of kwashiorkor in Malawi [see comments]: Acta Paediatr. 2000 Feb;89(2):203-7. Unique Identifier : AIDSLINE MED/20173126; Manary MJ; Brewster DR; Department of Paediatrics, College of Medicine, University of; Malawi. MANARY@kids.wustl.edu; The case fatality rate for children with kwashiorkor in central hospitals in Malawi was 30.5% (275/901) in 1995. The purpose of this study was to determine whether improved case management with intensive nursing care could lower this case fatality rate. A total of 75 children admit
Drug company bosses jailed for selling HIV infected products [news]: BMJ. 2000 Mar 4;320(7235):601. Unique Identifier : AIDSLINE MED/20164234; Lamar J
HTLV-I/II associated disease in England and Wales, 1993-7: retrospective review of serology requests.: BMJ. 2000 Mar 4;320(7235):611-2. Unique Identifier : AIDSLINE MED/20164242; Tosswill JH; Taylor GP; Tedder RS; Mortimer PP; Virus Reference Division, Central Public Health Laboratory,; London NW9 5HT.
Prevalence of antibodies to HTLV in blood donors in north London [letter]: BMJ. 2000 Mar 4;320(7235):650. Unique Identifier : AIDSLINE MED/20164265; Barbara J; Moore MC; Hewitt PE
Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient.: Leuk Lymphoma. 1999 Oct;35(3-4):379-87. Unique Identifier : AIDSLINE GENBANK/AF042372; Morand P; Buisson M; Collandre H; Chanzy B; Genoulaz O; Bourgeat MJ; Pinel N; Leclercq P; Leroux D; Marechal V; Fritsch L; Ruigrok R; Seigneurin JM; Laboratoire de Virologie Medicale Moleculaire (RHAP), Grenoble,; France. Patrice.Morand@ujf-grenoble.fr; Human Herpesvirus 8 (HHV-8) has been consistently associated with Primary Effusion Lymphoma (PEL or body-cavity-based lymphoma) but not with other lymphomas. This paper reports on an AIDS patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where HHV-8 and Epstein-Barr virus (EBV)
Reconciling quality measurement with financial risk adjustment in health plans.: Jt Comm J Qual Improv. 2000 Mar;26(3):137-46. Unique Identifier : AIDSLINE MED/20173923; Dudley RA; Bowers LV; Luft HS; Department of Medicine, University of California, San Francisco; 94118, USA. adudley@itsa.uscf.edu; BACKGROUND: Initiatives to improve quality measurement (QM) and to create systems for financial risk adjustment (RA) have developed in response to concerns about price competition s threat to quality and stimulation of risk selection. QM is designed to help purchasers identify best plans, to aid plans in their selecti
Efficient gene transfer and expression in islets by an adenoviral vector that lacks all viral genes.: Cell Transplant. 1999 Nov-Dec;8(6):661-71. Unique Identifier : AIDSLINE MED/20163430; Guo Z; Shen J; Mital D; Hong Y; Alemany R; Zhong WW; Jensik SC; Williams JW; Department of General Surgery, Rush-Presbyterian-St. Lukes's; Medical Center, Chicago, IL 60612, USA. zhiguang@tc.umn.edu; Although adenoviral vector-mediated gene transfer has significant potential for gene therapy, host immune responses to virally expressed proteins and small insert capacity may limit its clinical application. In order to overcome these disadvantages, a new adenoviral vector that lacks all viral genes has been developed
Spontaneous carotid artery aneurysms.: Br J Surg. 2000 Feb;87(2):186-90. Unique Identifier : AIDSLINE MED/20137844; Nair R; Robbs JV; Naidoo NG; Metropolitan Vascular Service, Department of Surgery, University; of Natal, Durban, South Africa.; BACKGROUND: Spontaneous carotid artery aneurysms are infrequently reported, and are almost always non-atherosclerotic. METHODS: The records of 29 patients with a spontaneous carotid aneurysm treated in an academic vascular unit between 1990 and 1998 were reviewed. RESULTS: All 29 patients were black South Africans; th
Unison's campaign to prevent needlestick injuries.: Community Nurse. 1999 Oct;5(9):35. Unique Identifier : AIDSLINE MED/20197125; Pinkney J
Dilemmas in conducting qualitative sex research in applied field settings [see comments]: Health Educ Behav. 2000 Feb;27(1):10-23. Unique Identifier : AIDSLINE MED/20173023; Seal DW; Bloom FR; Somlai AM; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53202, USA. dseal@mcw.edu; Although resources are available to inform researchers of the many technical skills necessary to conduct qualitative research, individuals working in applied field settings often encounter ethical, moral, and sociopolitical dilemmas that cannot be resolved through the application of technical skills. The purpose of th
Induction of a germinal center phenotype in B cells in vitro by a Th2 cell line.: Cell Immunol. 1999 Dec 15;198(2):77-86. Unique Identifier : AIDSLINE MED/20115380; Morafo V; Rath S; Thomas ML; Durdik JM; Department of Biological Sciences, University of Arkansas,; Fayetteville, Arkansas 72701, USA.; We have investigated the contribution of various stimuli for generating in vitro the changes in surface phenotype characteristic of B cells responding to a T-dependent antigen in a germinal center (GC). We show that, unlike many other stimuli such as B cell mitogens, cytokines, and surrogate antigen, alone or in combi
Shedding of soluble receptor for tumor necrosis factor alpha induced by M. leprae or LPS from human mononuclear cells.: Nihon Hansenbyo Gakkai Zasshi. 1999 Nov;68(3):185-93. Unique Identifier : AIDSLINE MED/20124839; Santos DO; Lorre K; de Boer M; Van Heuverswyn H; Department of Cellular and Molecular Biology, University Federal; Fluminense, Niteroi, Brasil.; Cell surface expression and release of the tumor necrosis factor receptor (TNFR type I) was analyzed after stimulation of peripheral blood mononuclear cells (PBMC) with Mycobacterium leprae (M. leprae) or lipopolysaccharide (LPS). A transient spontaneous expression of TNFR type I on the surface of PBMC was observed. T
Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients.: J Biochem Mol Toxicol. 2000;14(3):140-7. Unique Identifier : AIDSLINE MED/20174771; Teo SK; Sabourin PJ; O'Brien K; Kook KA; Thomas SD; Celgene Corporation, Warren, NJ 07059, USA. steo@celgene.com; Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we examined the extent of thalidomide metabolism by preparations of pooled human microsomes, microsomes containing cloned human CYP isozymes (CYPIA2, CYP2A6, CYP2B6, CY
Lung-specific immune response in tuberculosis.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S11-7. Unique Identifier : AIDSLINE MED/20150851; Condos R; Rom WN; Weiden M; New York University School of Medicine, Department of Medicine,; Division of Pulmonary and Critical Care, Bellevue Chest Service,; New York, New York 10016, USA. condor01@mcgc16.med.nyu.edu
Global AIDS 1981-1999: the response.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S24-33. Unique Identifier : AIDSLINE MED/20150853; Slutkin G; Epidemiology and International Health, School of Public Health,; University of Illinois at Chicago, 60612, USA. gslutkin@uic.edu
Use of clinical risk assessments in evaluation of nucleic acid amplification tests for HIV/tuberculosis.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S34-40. Unique Identifier : AIDSLINE MED/20150854; Perry S; Catanzaro A; Department of Medicine, Division of Pulmonary and Critical Care,; University of California, San Diego, USA.
Molecular determinants of drug resistance in tuberculosis.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S4-10. Unique Identifier : AIDSLINE MED/20150850; Riska PF; Jacobs WR Jr; Alland D; State University of New York-Health Science Center at Brooklyn,; New York, USA.; Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-bas
Applying advances to the clinic and health care delivery: putting the strategies to work.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S41-4. Unique Identifier : AIDSLINE MED/20150855; Ashkar BE; Consultation Services, County of Los Angeles Department of Health; Services Tuberculosis Control Program, California 90007, USA.; bashkar699@aol.com
Community responses to HIV/TB in Canada: a discussion of issues addressed in the HIV/TB Project of the Canadian AIDS Society.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S49-54. Unique Identifier : AIDSLINE MED/20150857; Zack E; Canadian Working Group on HIV Rehabilitation, Toronto.; ezack@interlog.com
Applying advances to the developing world for TB and HIV control.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S65-70. Unique Identifier : AIDSLINE MED/20150860; Harries AD; Foundation Professor of Medicine, College of Medicine, Malawi,; Technical Advisor, Malawi National Tuberculosis Programme,; Lilongwe. adharries@malawi.net
The impact of drug resistance on the global tuberculosis epidemic.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S71-5. Unique Identifier : AIDSLINE MED/20150861; Schluger NW; The Division of Pulmonary, Allergy, and Critical Care Medicine,; Columbia University College of Physicians and Surgeons, New York,; New York 10032, USA. ns311@columbia.edu
Tuberculosis preventive therapy for HIV-infected persons in less developed countries.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S76-81. Unique Identifier : AIDSLINE MED/20150862; Kritski AL; Unidade de Pesquisa em Tuberculose, Servico de Pneumologia,; Hospital Universitario Clementino Fraga Filho/Universidade; Federal do Rio de Janeiro (HUCFF/UFRJ), Brazil.; akritski@infolink.com.br
Translating discoveries into control of tuberculosis in HIV-infected persons.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S82-7. Unique Identifier : AIDSLINE MED/20150863; Hopewell PC; University of California, San Francisco, California 94110, USA.; phopewel@sfghdean.ucsf.edu
The availability of local and affordable treatments for AIDS in Sub-Saharan Africa.: J Altern Complement Med. 1999 Dec;5(6):505-7. Unique Identifier : AIDSLINE MED/20094040; Homsy J; Traditional and Modern Health Practitioners Together Against; AIDS, Kampala, Uganda. jaco@capp.ch
Evaluating herbal medicine for the management of Herpes zoster in human immunodeficiency virus-infected patients in Kampala, Uganda.: J Altern Complement Med. 1999 Dec;5(6):553-65. Unique Identifier : AIDSLINE MED/20094045; Homsy J; Katabira E; Kabatesi D; Mubiru F; Kwamya L; Tusaba C; Kasolo S; Mwebe D; Ssentamu L; Okello M; King R; Traditional and Modern Health Practitioners Together Against AIDS; (THETA), Kampala, Uganda.; OBJECTIVE: This study was carried out to evaluate the potential effectiveness of herbal treatments used for herpes zoster (HZ) by a great number of people living with acquired immunodeficiency syndrome (PLWAs) in Uganda . SETTING: Kampala, Uganda. Clinics of indigenous traditional h
Nutrients and HIV: part two--vitamins A and E, zinc, B-vitamins, and magnesium.: Altern Med Rev. 2000 Feb;5(1):39-51. Unique Identifier : AIDSLINE MED/20161034; Patrick L; There is compelling evidence that micronutrient deficiencies can profoundly affect immunity; micronutrient deficiencies are widely seen in HIV, even in asymptomatic patients. Direct relationships have been found between deficiencies of specific nutrients, such as vitamins A and B12, and a decline in CD4 counts. Defici
Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):235-8. Unique Identifier : AIDSLINE MED/20162269; Singh SB; Felock P; Hazuda DJ; Natural Products Drug Discovery, Merck Research Laboratories,; Rahway, NJ 07065, USA. sheo_singh@merck.com; Integric acid (1), an acyl eremophilane sesquiterpenoid, was identified as an inhibitor of HIV-1 integrase, the enzyme responsible for provirus entry into the host cell nucleus and integration in to the host genome. Chemical and enzymatic modification of integric acid led to the preparation of several selective chemic
Recognition and inhibition of HIV integrase by a novel dinucleotide.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):249-51. Unique Identifier : AIDSLINE MED/20162272; Taktakishvili M; Neamati N; Pommier Y; Nair V; Department of Chemistry, The University of Iowa, Iowa City 52242,; USA.; The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually
1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole: a potent lead for the design of novel NNRTIs.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):253-6. Unique Identifier : AIDSLINE MED/20162273; Silvestri R; Artico M; Massa S; Marceddu T; De Montis F; La Colla P; Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di; Studi Farmaceutici, Universita di Roma La Sapienza, Rome, Italy.; A novel family of non-nucleoside reverse transcriptase inhibitors (NNRTIs) active at submicromolar concentrations was discovered. The new derivatives are 1-[2-(diarylmethoxy)ethyl]imidazoles bearing substituents both at benzene and imidazole rings. The most potent derivatives were those having nitro and methyl groups
Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):265-8. Unique Identifier : AIDSLINE MED/20162276; Hogberg M; Engelhardt P; Vrang L; Zhang H; Medivir AB, Huddinge, Sweden. marita.hogberg@medivir.se; Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenethyl group with benzoylethyl group (compounds 11-20) have been studied. Synthesis and antiviral activities are descri
Effect of application volume of ethanol-isopropyl myristate mixed solvent system on permeation of zidovudine and probenecid through rat skin.: Drug Dev Ind Pharm. 2000 Feb;26(2):193-8. Unique Identifier : AIDSLINE MED/20162864; Jin Y; Seki T; Morimoto Y; Juni K; Research Institute of TTS Technology, Saitama, Japan.; Permeation of zidovudine ( AZT ) and probenecid from an ethanol-isopropyl myristate (IPM) mixed system through rat skin was studied in a finite system. Several volume sizes of the ethanol-IPM mixed systems containing AZT and probenecid, both as suspensi
Are women disfavoured in the estimation of disability adjusted life years and the global burden of disease?: Scand J Public Health. 1999 Dec;27(4):279-85. Unique Identifier : AIDSLINE MED/20187066; Sundby J; Section for Medical Anthropology, Institute of General Practice; and Community Medicine, University of Oslo, Norway.; Addressing women s health goes beyond merely producing gender-disaggregated data. A women s perspective on health issues involves an analysis based on knowledge of broader gender differences than those that can be attributed to biology alone. Women and men live different lives. It is therefore important to evaluate wh
Human immunodeficiency virus: post-exposure prophylaxis.: Curr Opin Urol. 1999 Jan;9(1):51-5. Unique Identifier : AIDSLINE MED/20190271; Parschalk B; Pernerstorfer-Schon H; Department for Infectious Diseases, Internal Medicine I,; University Hospital of Vienna, Austria.; Post-exposure prevention is a combined modality approach to reducing HIV transmission. The recommendations are based on the risk of local prevalence and on the likelihood of transmission. In the light of the severe consequences of HIV infection, post-exposure prophylaxis after occupational exposure should be recommend
1st International Conference on the Discovery and Clinical Development of Antiretroviral Therapies. St. Thomas, West Indies, US Virgin Islands. 13-17 December 1998. Abstracts.: Antivir Ther. 1998;3 Suppl 5:3-99. Unique Identifier : AIDSLINE MED/20196710
Blockage of HIV-1 production through inhibition of proviral DNA synthesis by N,O-didecanoyl serinal dimethylacetal.: IUBMB Life. 1999 Sep;48(3):311-5. Unique Identifier : AIDSLINE MED/20155234; Takamune N; Misumi S; Furuishi K; Shoji S; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Kumamoto University, Japan.; Six serinal derivatives were synthesized and tested for their anti-human immunodeficiency virus type-1 (HIV-1) activity against HIV-1-infected cells. Of the 6 serinal derivatives tested, only N,O-didecanoyl serinal dimethylacetal (DDSD) was found to strongly suppress progeny virus production from acute HIV-1-infected
Significance of detecting Epstein-Barr-specific sequences in the peripheral blood of asymptomatic pediatric liver transplant recipients.: Liver Transpl. 2000 Jan;6(1):62-6. Unique Identifier : AIDSLINE MED/20167469; Krieger NR; Martinez OM; Krams SM; Cox K; So S; Esquivel CO; Stanford University Medical Center, Stanford, CA 94304-1510, USA.; Pediatric allograft recipients are at increased risk for Epstein-Barr virus (EBV)-associated illnesses. The early identification and diagnosis of EBV-associated disorders is critical because disease progression can often be curtailed by modification of immunosuppression. We have previously shown that detection of EBV-
Cognitive-behavioral stress management increases free testosterone and decreases psychological distress in HIV-seropositive men.: Health Psychol. 2000 Jan;19(1):12-20. Unique Identifier : AIDSLINE MED/20174725; Cruess DG; Antoni MH; Schneiderman N; Ironson G; McCabe P; Fernandez JB; Cruess SE; Klimas N; Kumar M; Department of Psychology, University of Miami, Coral Gables,; Florida 33124-2070, USA.; The effects of a 10-week group-based cognitive-behavioral stress management (CBSM) intervention on psychological distress and plasma free testosterone in symptomatic, HIV-seropositive men were examined. Participants were randomized to either CBSM (n = 42) or a wait-list control group (n = 23). Men in the CBSM interven
Using information, motivational enhancement, and skills training to reduce the risk of HIV infection for low-income urban women: a second randomized clinical trial.: Health Psychol. 2000 Jan;19(1):3-11. Unique Identifier : AIDSLINE MED/20174724; Carey MP; Braaten LS; Maisto SA; Gleason JR; Forsyth AD; Durant LE; Jaworski BC; Department of Psychology, Center for Health and Behavior,; Syracuse University, New York 13244-2340, USA. mpcarey@syr.edu; This randomized clinical trial evaluated an HIV-risk reduction (HIV-RR) intervention based on the information-motivation-behavioral skills model. At baseline, 102 women (M age = 29 years; 88% African American) completed a survey regarding HIV-related knowledge, risk perceptions, behavioral intentions, and risk behavio
Prevalence of serum antibodies against bloodborne and sexually transmitted agents in selected groups in Somalia.: Epidemiol Infect. 2000 Feb;124(1):137-41. Unique Identifier : AIDSLINE MED/20185216; Nur YA; Groen J; Elmi AM; Ott A; Osterhaus AD; Institute of Virology, WHO Collaborating Center of Arboviruses; and Haemorrhagic Fever viruses, Reference and Research,; University Hospital Rotterdam, The Netherlands.; Somalia has suffered from a civil war during the last 10 years. In this period the use of whole blood has increased at least twofold in Mogadishu, Somalia compared with pre-war. Screening possibilities are limited. Recent data concerning the prevalence of infections with blood-bor
Cross-sectional study on risk factors of HIV among female commercial sex workers in Cambodia.: Unique Identifier : AIDSLINE MED/20185217; Ohshige K; Morio S; Mizushima S; Kitamura K; Tajima K; Ito A; Suyama A; Usuku S; Saphonn V; Heng S; Hor LB; Tia P; Soda K; Department of Public Health, Yokohama City University, School of; Medicine, Japan.; To describe epidemiological features on HIV prevalence among female commercial sex workers (CSWs), a cross-sectional study on sexual behaviour and serological prevalence was carried out in Cambodia . The CSWs were interviewed on their demographic characters and behaviour and their
Risk factors for pulmonary disease due to culture-positive M. tuberculosis or nontuberculous mycobacteria in South African gold miners.: Eur Respir J. 2000 Feb;15(2):291-6. Unique Identifier : AIDSLINE MED/20169011; Sonnenberg P; Murray J; Glynn JR; Thomas RG; Godfrey-Faussett P; Shearer S; Dept of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.; The aim of this study was to determine risk factors for disease due to nontuberculous mycobacteria (NTM) compared to those due to Mycobacterium tuberculosis in South African gold miners with pulmonary mycobacterial disease. A case/control study comparing tuberculosis and NTM cases amongst all patients with a positive
Tuberculosis among health care workers during three recent decades.: Eur Respir J. 2000 Feb;15(2):304-7. Unique Identifier : AIDSLINE MED/20169013; Raitio M; Tala E; Dept of Chest Diseases, Turku University Central Hospital,; Finland.; Some studies have found that health care workers have an increased risk of tuberculosis, whereas other studies have reported the opposite. This study examined data of Finnish health care workers (HCWs) for the incidence of tuberculosis disease. Cases of occupational tuberculosis in
Voices from the clinic: AIDS then and now.: Health Aff (Millwood). 2000 Mar-Apr;19(2):191-7. Unique Identifier : AIDSLINE MED/20182496; Zuger A
[Correlations of T lymphocyte subsets and IL-2, sIL-2R in patients with malignant ovarian tumor]: Hua Hsi I Ko Ta Hsueh Hsueh Pao. 1997 Jun;28(2):210-3. Unique Identifier : AIDSLINE MED/20147561; Wang H; Peng Z; Zhang C; Department of Obstetrics and Gynecology, Second Affiliated; Hospital, Chengdu.; To study the relation between malignant ovarian tumor (MOT) and cell mediated immunity, the numbers of T lymphocyte subsets and levels of IL-2 and sIL-2R were measured simultaneously in 40 patients with MOT and 30 normal controls (NC), and the correlations between T su
Epitope-vaccine induces high levels of ELDKWA-epitope-specific neutralizing antibody.: Immunol Invest. 2000 Feb;29(1):41-50. Unique Identifier : AIDSLINE MED/20173079; Xiao Y; Zhao Y; Lu Y; Chen YH; Laboratory of Immunology, Research Centre for Medical Science and; the School of Life Science and Engineering, Tsinghua University,; Beijing, P.R. China.; Based on the fact that mAb 2F5 recognizing ELDKWA-epitope on the C-domain of HIV-1 gp41 has significant neutralization potency against 90% of the investigated viruses of African, Asian, American and European strains, we attempted to characterise immunogenicity of the ELDKWA-epitope on an epitope-vaccine, and to produc
The impact of HIV on meningitis as seen at a South African Academic Hospital (1994 to 1998).: Infection. 2000 Jan-Feb;28(1):3-7. Unique Identifier : AIDSLINE MED/20162891; Schutte CM; Van der Meyden CH; Magazi DS; Dept. of Neurology, University of Pretoria, South Africa.; cschutte@medic.up.ac.za; BACKGROUND: The increase in HIV infections in South Africa is alarming. The aim of this prospective 4-year study was to evaluate the rising incidence of HIV-related admissions due to meningitis at the Pretoria Academic Hospital (PAH) adult neurology ward and to investigate the spe
Specific in vitro proliferative immune responses and lymphokine production in Ethiopian children with and without tuberculosis.: Infection. 2000 Jan-Feb;28(1):42-5. Unique Identifier : AIDSLINE MED/20162899; Kori M; Barak V; Leibovitz E; Altman Y; Eliraz A; Handzel ZT; Kaplan Hospital, Kaplan Medical Center, Rehovot, Israel.; We investigated the profile of some in vitro parameters of cellular immune responses in non-HIV-infected Ethiopian children and young adults with and without tuberculosis (TB) as compared to healthy Ethiopian and non-Ethiopian controls. The in vitro proliferative responses of peripheral blood mononuclear cells (PBMC)
Is interruption of HIV therapy always harmful?: J Antimicrob Chemother. 2000 Feb;45(2):137-8. Unique Identifier : AIDSLINE MED/20127813; Youle M; Royal Free Centre for HIV Medicine, Royal Free Hospital, Pond; Street, London NW3 2QG, UK.
In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy.: J Antimicrob Chemother. 2000 Feb;45(2):239-42. Unique Identifier : AIDSLINE MED/20127829; Rodero L; Cordoba S; Cahn P; Hochenfellner F; Davel G; Canteros C; Kaufman S; Guelfand L; Departamento Micologia, Instituto Nacional de Enfermedades; Infecciosas, ANLIS 'Dr Carlos G. Malbran', Av. Velez Sarsfield; 563, 1281 Buenos Aires, Argentina. lrodero@mail.retina.ar; The in vitro activities of three antifungal drugs alone and in combination were evaluated against five isolates of Cryptococcus neoformans using time-kill curves (TKC). The isolates were from AIDS patients who had either died or had failed to show a clinical response during amphotericin B (AMB) treatment. AMB, flucona
Substitution of protease inhibitors during treatment of patients with human immunodeficiency virus infection: frequency, mode, reasons and mid-term outcome [letter]: J Antimicrob Chemother. 2000 Feb;45(2):261-3. Unique Identifier : AIDSLINE MED/20127836; Manfredi R; Chiodo F
Evolution of drug resistance in experimental populations of Candida albicans.: J Bacteriol. 2000 Mar;182(6):1515-22. Unique Identifier : AIDSLINE MED/20158866; Cowen LE; Sanglard D; Calabrese D; Sirjusingh C; Anderson JB; Kohn LM; Department of Botany, University of Toronto, Mississauga,; Ontario, Canada L5L 1C6. lcowen@credit.erin.utoronto.ca; Adaptation to inhibitory concentrations of the antifungal agent fluconazole was monitored in replicated experimental populations founded from a single, drug-sensitive cell of the yeast Candida albicans and reared over 330 generations. The concentration of fluconazole was maintained at twice the MIC in six populations;
Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150.: J Biochem (Tokyo). 1999 Dec;126(6):1033-42. Unique Identifier : AIDSLINE GENBANK/AA556203; Shimada M; Saito M; Katakai T; Shimizu A; Ichimura T; Omata S; Horigome T; Course of Advanced Material Science, Graduate School of Science; and Technology, Niigata University, 2-Igarashi, Niigata,; 950-2181, Japan.; We previously characterized p144 bearing N-acetylglucosamine residues in a rat liver nuclear matrix fraction. Based on partial amino acid sequences of rat p144, mouse p144 cDNA was cloned and sequenced, and its amino acid sequence was predicted. The sequence revealed that p144 is a rat homologue of CA150, which is a t
Human vascular smooth muscle cells possess functional CCR5.: J Biol Chem. 2000 Feb 25;275(8):5466-71. Unique Identifier : AIDSLINE MED/20148745; Schecter AD; Calderon TM; Berman AB; McManus CM; Fallon JT; Rossikhina M; Zhao W; Christ G; Berman JW; Taubman MB; Zena and Michael A. Wiener Cardiovascular Institute, The Mount; Sinai School of Medicine, New York, New York 10029, USA.; CC chemokine receptors are important modulators of inflammation. Although CC chemokine receptors have been found predominantly on leukocytes, recent studies have suggested that vascular smooth muscle cells respond to CC chemokines. We now report that human smooth muscle cells express CCR5, a co-receptor for human immu
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.: J Biol Chem. 2000 Feb 25;275(8):5633-9. Unique Identifier : AIDSLINE PDB/1DTTSF; Ren J; Diprose J; Warren J; Esnouf RM; Bird LE; Ikemizu S; Slater M; Milton J; Balzarini J; Stuart DI; Stammers DK; Structural Biology Division, The Wellcome Trust Centre for Human; Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN,; United Kingdom.; Most non-nucleoside reverse transcriptase (RT) inhibitors are specific for HIV-1 RT and demonstrate minimal inhibition of HIV-2 RT. However, we report that members of the phenylethylthiazolylthiourea (PETT) series of non-nucleoside reverse transcriptase inhibitors showing high potency against HIV-1 RT have varying abi
Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding.: J Cell Biochem. 2000 Feb;77(1):65-74. Unique Identifier : AIDSLINE MED/20145931; Wortman MJ; Krachmarov CP; Kim JH; Gordon RG; Chepenik LG; Brady JN; Gallia GL; Khalili K; Johnson EM; Department of Pathology and Brookdale Center for Molecular and; Developmental Biology, Mount Sinai School of Medicine, New York,; NY 10029, USA.; A complex between the Tat protein, encoded by human immunodeficiency virus type 1 (HIV-1), and the cellular protein, Puralpha, has been implicated in activation of the late promoter of JC virus (JCV) and in enhancement of JCV DNA replication. JCV is the causative agent of progressive multifocal leukoencephalopathy (PM
Factors influencing T-cell turnover in HIV-1-seropositive patients [see comments]: J Clin Invest. 2000 Mar;105(5):R1-8. Unique Identifier : AIDSLINE MED/20177756; McCune JM; Hanley MB; Cesar D; Halvorsen R; Hoh R; Schmidt D; Wieder E; Deeks S; Siler S; Neese R; Hellerstein M; The Gladstone Institute of Virology and Immunology, University of; California-San Francisco, San Francisco, California 94141, USA.; mmccune@gladstone.ucsf.edu; HIV-1 disease is associated with pathological effects on T-cell production, destruction, and distribution. Using the deuterated (2H) glucose method for endogenous labeling, we have analyzed host factors that influence T-cell turnover in HIV-1-uninfected and -infected humans. In untreated HIV-1 disease, the average hal
Normal physiology and HIV pathophysiology of human T-cell dynamics [comment]: J Clin Invest. 2000 Mar;105(5):565-6. Unique Identifier : AIDSLINE MED/20177742; Richman DD; Departments of Pathology and Medicine - 0679, San Diego Veterans; Affairs Medical Center and University of California-San Diego,; 9500 Gilman Drive, La Jolla, California 92037-0679, USA.; drichman@ucsd.edu
The role of nurses in AIDS care regarding voluntary euthanasia and assisted suicide: a call for further dialogue.: J Adv Nurs. 2000 Mar;31(3):513-9. Unique Identifier : AIDSLINE MED/20184229; Young MG; Ogden RD; Camosun College, Victoria, British Columbia, Canada; New; Westminster, British Columbia, Canada. michaely@uvic.ca; The role of nurses in AIDS care regarding voluntary euthanasia and assisted suicide: a call for further dialogue Because of the nature of their work, nurses are directly involved with terminally ill patients and the problems associated with the decision to hasten death through voluntary euthanasia or assisted suicide
German nursing students' knowledge of and attitudes to HIV and AIDS: two decades after the first AIDS cases.: J Adv Nurs. 2000 Mar;31(3):696-703. Unique Identifier : AIDSLINE MED/20184250; Lohrmann C; Valimaki M; Suominen T; Muinonen U; Dassen T; Peate I; Humboldt-Universitat, Institut fur Medizin-/Pflegepadagogik; und Pflegewissenschaft, Berlin, Germany. chrlohrmann@yahoo.com; German nursing students knowledge of and attitudes to HIV and AIDS: two decades after the first AIDS case This study describes German nursing students (n=180) knowledge and attitudes relating to HIV/AIDS, their homophobia level, willingness to care for people with AIDS, and their approach to possible sexual risk beh
HIV-infected surgical personnel under the ADA: do they pose a direct threat or are reasonable accommodations possible?: J Contemp Health Law Policy. 1999 Winter;16(1):127-46. Unique Identifier : AIDSLINE MED/20159571; Rohlfsen RJ
A national epidemic, a national conversation, a national law: in support of unique identifier reporting for HIV surveillance.: J Contemp Health Law Policy. 1999 Winter;16(1):173-209. Unique Identifier : AIDSLINE MED/20159573; Kramer KM
Post-transfusion HIV infection despite donor screening: a report of three cases.: J Hosp Infect. 2000 Feb;44(2):93-7. Unique Identifier : AIDSLINE MED/20130304; Martlew VJ; Carey P; Tong CY; Parry JV; Belda FJ; Barlow KL; Chu P; Syed Q; Department of Haematology, Royal Liverpool University Hospital.; In August 1996, a blood donation was collected which subsequently infected three patients post-transfusion with HIV 1. The donation itself was originally screened as negative for anti-HIV 1/2 using a sensitive EIA method, but subsequently was shown to contain p24 Ag and HIV RNA by an amplification technique. The propo
Risk of HIV transmission from patients to surgeons in the era of post-exposure prophylaxis.: Unique Identifier : AIDSLINE MED/20130305; Goldberg D; Johnston J; Cameron S; Fletcher C; Stewart M; McMenamin J; Codere G; Hutchinson S; Raeside F; The HIV prevalence, among patients either undergoing, or with the potential to undergo, surgery were estimated using data from unlinked anonymous HIV surveys of patients in Glasgow hospitals during 1992-1997 in order to quantify the risk of surgeons acquiring HIV occupationally in the era of post-exposure prophylaxis
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.: J Immunol. 2000 Mar 15;164(6):2861-5. Unique Identifier : AIDSLINE MED/20171480; Heath VL; Showe L; Crain C; Barrat FJ; Trinchieri G; O'Garra A; Department of Immunobiology, DNAX Research Institute, Palo Alto,; CA 94304, USA. Heath@DNAX.org; The IL-12 receptor-beta 2 (IL-12R beta 2) chain is expressed on Th1 cells and lost upon differentiation to the Th2 phenotype. This has been suggested as the basis for commitment of Th1 cells, because early differentiated Th2 cells do not reverse their phenotype and do not produce IFN-gamma on restimulation in the pres
A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells.: J Immunol. 2000 Mar 15;164(6):2890-6. Unique Identifier : AIDSLINE MED/20171484; Blanas E; Davey GM; Carbone FR; Heath WR; Walter and Eliza Hall Institute of Medical Research, Melbourne,; Victoria, Australia.; We have previously reported that feeding OVA to C57BL/6 mice can lead to a weak CTL response that is dependent on CD4+ T cell help and is capable of causing autoimmunity. In this study, we investigated the basis of the class I and class II-restricted Ag presentation required for such CTL induction. Two days after feed
CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen.: J Immunol. 2000 Mar 15;164(6):2955-63. Unique Identifier : AIDSLINE MED/20171492; Rogers PR; Croft M; Division of Immunochemistry, La Jolla Institute for Allergy and; Immunology, San Diego, CA 92121, USA.; The involvement of specific accessory/costimulatory molecules in differentiation to Th1 and Th2 phenotypes is controversial. Reports suggest that molecules such as CD4, CD28, and Ox-40 support Th2 differentiation and suppress Th1 differentiation, whereas others such as LFA-1 support Th1 responses and suppress Th2 resp
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile.: J Immunol. 2000 Mar 15;164(6):3047-55. Unique Identifier : AIDSLINE MED/20171503; Jankovic D; Kullberg MC; Noben-Trauth N; Caspar P; Paul WE; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, and; Laboratory of Immunology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA. djankovic@niaid.nih.gov; The concept that IL-4 is the primary signal for Th2 lymphocyte differentiation has recently been put in doubt by studies in which the production of Th2-associated cytokines was detected in mice deficient in IL-4 synthesis or IL-4R triggering. In this study, we formally demonstrate by single cell analysis that CD4+ lym
Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression.: J Immunol. 2000 Mar 15;164(6):3056-64. Unique Identifier : AIDSLINE MED/20171504; Yin Z; Zhang DH; Welte T; Bahtiyar G; Jung S; Liu L; Fu XY; Ray A; Craft J; Sections of Rheumatology and Pulmonary and Critical Care; Medicine, Department of Medicine, Department of Pathology, and; Section of Immunobiology, Yale School of Medicine, New Haven, CT; 06520, USA.; Gamma delta T cells secrete Th1- and Th2-like cytokines that help mediate innate and acquired immunity. We have addressed the mechanism whereby murine gamma delta T cells acquire the capacity to differentially produce such cytokines. Splenic gamma delta T cells could be polarized into IFN-gamma- or IL-4-secreting cell
Induction of diabetes in nonobese diabetic mice by Th2 T cell clones from a TCR transgenic mouse.: J Immunol. 2000 Mar 15;164(6):3072-8. Unique Identifier : AIDSLINE MED/20171506; Poulin M; Haskins K; Department of Immunology and Barbara Davis Center for Childhood; Diabetes, University of Colorado Health Sciences Center, Denver,; CO 80262, USA.; We have produced a panel of cloned T cell lines from the BDC-2.5 TCR transgenic (Tg) mouse that exhibit a Th2 cytokine phenotype in vitro but are highly diabetogenic in vivo. Unlike an earlier report in which T cells obtained from the Tg mouse were cultured for 1 wk under Th2-promoting conditions and were found to ind
CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity.: Unique Identifier : AIDSLINE MED/20171509; Hermans IF; Ritchie DS; Yang J; Roberts JM; Ronchese F; The fate of dendritic cells (DC) after they have initiated a T cell immune response is still undefined. We have monitored the migration of DC labeled with a fluorescent tracer and injected
The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine.: J Immunol. 2000 Mar 15;164(6):3102-11. Unique Identifier : AIDSLINE MED/20171510; Kusakabe K; Xin KQ; Katoh H; Sumino K; Hagiwara E; Kawamoto S; Okuda K; Miyagi Y; Aoki I; Nishioka K; Klinman D; Okuda K; Departments of Bacteriology, Internal Medicine, and Pathology,; YokohamaCity University School of Medicine, Yokohama, Japan.; The mechanism of immune activation induced by a plasmid-encoding GM-CSF (pGM-CSF), administered in combination with a DNA vaccine encoding the envelope of HIV, was studied. Injecting pGM-CSF i.m. into mice 3 days before DNA vaccination primarily induced a Th2 response. Simultaneous administration of the DNA vaccine pl
Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy.: IC USE Viral Vaccines/GENETICS/*IMMUNOLOGY/THERAPEUTIC USE J Immunol. 2000 Mar 15;164(6):3112-22. Unique Identifier : AIDSLINE MED/20171511; Narvaiza I; Mazzolini G; Barajas M; Duarte M; Zaratiegui M; Qian C; Melero I; Prieto J; Departments ofMedicine and Genetics, Facultad de Medicina,; Universidad de Navarra, Pamplona, Spain.
Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes.: J Immunol. 2000 Mar 15;164(6):3236-45. Unique Identifier : AIDSLINE MED/20171526; Tellier MC; Greco G; Klotman M; Mosoian A; Cara A; Arap W; Ruoslahti E; Pasqualini R; Schnapp LM; Divisions of Pulmonary and Critical Care Medicine and Infectious; Disease, Mount Sinai School of Medicine, New York, NY 10029, USA.; The ability of viruses and bacteria to interact with the extracellular matrix plays an important role in their infectivity and pathogenicity. Fibronectin is a major component of the extracellular matrix in lymph node tissue, the main site of HIV deposition and replication during the chronic phase of infection. Therefo
CD4+ T cell priming accelerates the clearance of Sendai virus in mice, but has a negative effect on CD8+ T cell memory.: J Immunol. 2000 Mar 15;164(6):3274-82. Unique Identifier : AIDSLINE MED/20171530; Zhong W; Marshall D; Coleclough C; Woodland DL; Trudeau Institute, Saranac Lake, NY 12983, USA.; Current vaccines designed to promote humoral immunity to respiratory virus infections also induce potent CD4+ T cell memory. However, little is known about the impact of primed CD4+ T cells on the immune response to heterologous viruses that are serologically distinct, but that share CD4+ T cell epitopes. In addition,
Chemokines fail to up-regulate beta 1 integrin-dependent adhesion in human Th2 T lymphocytes.: Unique Identifier : AIDSLINE MED/20171532; Clissi B; D'Ambrosio D; Geginat J; Colantonio L; Morrot A; Freshney NW; Downward J; Sinigaglia F; Pardi R; Th1 and Th2 cells are functionally distinct subsets of CD4+ T lymphocytes whose tissue-specific homing to sites of inflammation is regulated in part by the differential expression of P- and E-selectin ligands and selected chemokine receptors. Here we investigated the expression and function of beta 1 integrins in Th1
Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: implications for tubulointerstitial injury in chronic glomerulonephritides.: J Immunol. 2000 Mar 15;164(6):3323-9. Unique Identifier : AIDSLINE MED/20171536; Kuroiwa T; Schlimgen R; Illei GG; McInnes IB; Boumpas DT; Arthritis and Rheumatism Branch, National Institute of Arthritis; and Musculoskeletal and Skin Diseases, National Institutes of; Health, Bethesda, MD 20892, USA. kuroiwat@arb.niams.nih.gov; Chemokines can promote interstitial fibrosis that is, in turn, a strong predictor of renal failure in chronic glomerulonephritides (GN). Resident renal cells, including renal tubular epithelial cells (RTEC), represent a prominent source of chemokine expression. Evaluating those factors responsible for sustained chemok
Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.: J Immunol. 2000 Mar 15;164(6):3368-76. Unique Identifier : AIDSLINE MED/20171542; Muehlhoefer A; Saubermann LJ; Gu X; Luedtke-Heckenkamp K; Xavier R; Blumberg RS; Podolsky DK; MacDermott RP; Reinecker HC; Gastrointestinal Unit, Department of Medicine, Center for the; Study of Inflammatory Bowel Disease, Massachusetts General; Hospital and Harvard Medical School, Boston, MA 02114, USA.; Fractalkine is a unique chemokine that combines properties of both chemoattractants and adhesion molecules. Fractalkine mRNA expression has been observed in the intestine. However, the role of fractalkine in the healthy intestine and during inflammatory mucosal responses is not known. Studies were undertaken to determ
In vitro priming with adenovirus/gp100 antigen-transduced dendritic cells reveals the epitope specificity of HLA-A*0201-restricted CD8+ T cells in patients with melanoma.: J Immunol. 2000 Mar 15;164(6):3402-12. Unique Identifier : AIDSLINE MED/20171546; Linette GP; Shankara S; Longerich S; Yang S; Doll R; Nicolette C; Preffer FI; Roberts BL; Haluska FG; Hematology-Oncology Unit and Department of Pathology,; Massachusetts General Hospital, Boston, MA 02114, USA.; linette.gerald@mgh.harvard.edu; Replication-deficient recombinant adenovirus (Ad) encoding human gp100 or MART-1 melanoma Ag was used to transduce human dendritic cells (DC) ex vivo as a model system for cancer vaccine therapy. A second generation E1/E4 region deleted Ad which harbors the CMV
CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitro.: J Immunol. 2000 Mar 15;164(6):3426-33. Unique Identifier : AIDSLINE MED/20171549; Lopalco L; Barassi C; Pastori C; Longhi R; Burastero SE; Tambussi G; Mazzotta F; Lazzarin A; Clerici M; Siccardi AG; Department of Biological and Technological Research and; Infectious Diseases Clinic, San Raffaele Scientific Institute,; Milano, Italy. lopalco.lucia@hsr.it; Exposure to HIV does not necessarily result in infection. Because primary HIV infection is associated with CCR5-tropic HIV variants (R5), CCR5-specific Abs in the sera of HIV-seronegative, HIV-exposed individuals (ESN) might be associated with protection against infection. We analyzed sera from ESN, their HIV-infected
HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer.: J Endocrinol. 2000 Feb;164(2):R7-R10. Unique Identifier : AIDSLINE MED/20126018; Wentworth JM; Burris TP; Chatterjee VK; Level 5, Department of Medicine, Addenbrookes, Cambridge CB2 2QQ,; UK.; A recent prospective clinical study has shown that antiviral therapy with HIV protease inhibitors (PIs) is associated with a syndrome of peripheral fat wasting (lipodystrophy) and disordered glucose and lipid metabolism (Carr et al. 1999). We have studied the effect
How does tuberculosis relate to HIV positive and HIV negative drug users?: J Epidemiol Community Health. 2000 Jan;54(1):64-8. Unique Identifier : AIDSLINE MED/20157354; Keizer ST; Langendam MM; van Deutekom H; Coutinho RA; van Ameijden EJ; Department for Tuberculosis-control, Amsterdam Municipal Health; Service, The Netherlands.; OBJECTIVES: (1) To compare the incidence of active tuberculosis in HIV positive and HIV negative drug users. (2) To describe the main characteristics of the tuberculosis cases. DESIGN: A prospective study was performed from 1986 to 1996 as part of an ongoing cohort study of HIV infection in Amsterdam drug users. METHO
Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women.: J Gen Virol. 2000 Mar;81 Pt 3:701-8. Unique Identifier : AIDSLINE MED/20141382; Petter A; Heim K; Guger M; Ciresa-Ko Nig A; Christensen N; Sarcletti M; Wieland U; Pfister H; Zangerle R; Hopfl R; Department of Dermatology, University Clinic, Anichstrabetae 35,; A-6020 Innsbruck, Austria. anton.petter@uibk.ac.at; To evaluate the humoral immune response to human papillomavirus (HPV) in women infected with human immunodeficiency virus (HIV), serum samples of 83 HIV-positive individuals were analysed by ELISA for specific antibodies of the isotypes IgG, IgA and IgM recognizing HPV-6, -11, -16, -18 and -31 L1 virus-like particles
Subterminal viral DNA nucleotides as specific recognition signals for human immunodeficiency virus type 1 and visna virus integrases under magnesium-dependent conditions.: J Gen Virol. 2000 Mar;81 Pt 3:839-49. Unique Identifier : AIDSLINE MED/20141397; Morgan AL; Katzman M; Department of Microbiology, The Milton S. Hershey Medical Center,; Pennsylvania State University College of Medicine, Hershey, PA; 17033-0850, USA.; Many reports describe the characteristics of susceptible viral DNA substrates to various retroviral integrases during in vitro reactions in which manganese serves as the divalent cation cofactor for site-specific nicking. However, manganese is known to alter the specificity of some endonucleases and magnesium may be t
Th1 dominance in HAM/TSP and the optico-spinal form of multiple sclerosis versus Th2 dominance in mite antigen-specific IgE myelitis.: J Neurol Sci. 2000 Jan 1;172(1):17-24. Unique Identifier : AIDSLINE MED/20088932; Horiuchi I; Kawano Y; Yamasaki K; Minohara M; Furue M; Taniwaki T; Miyazaki T; Kira Ji; Department of Neurology, Neurological Institute, Graduate School; of Medical Sciences, Kyushu University, Fukuoka, Japan.; To clarify the Th1/Th2 balance in spinal cord inflammation, we used ELISA to measure the total and allergen-specific IgE in 69 patients with clinically definite multiple sclerosis (MS), including 24 patients with the optico-spinal form of MS, 45 with HAM/TSP, 30 HTLV-I carriers without HAM/TSP, 40 patients with acute
Dominant human herpesvirus type 8 RNA transcripts in classical and AIDS-related Kaposi's sarcoma.: J Pathol. 1999 Apr;187(5):582-7. Unique Identifier : AIDSLINE MED/99359555; Linderoth J; Rambech E; Dictor M; Department of Oncology, University of Lund Hospital, Solvegatan; 25, S-221 85 Lund, Sweden.; Skin biopsy sections of Kaposi s sarcoma (KS) from 25 patients (5 AIDS-related, 20 classical cases) were histologically staged and hybridized in situ with oligonucleotide probes for constitutively transcribed human herpesvirus 8 (HHV-8) mRNA T0.7 and T1.1 using a colourimetric technique. T1.1 increases during experime
Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group.: JAMA. 2000 Mar 15;283(11):1445-50. Unique Identifier : AIDSLINE MED/20195072; Gordin F; Chaisson RE; Matts JP; Miller C; de Lourdes Garcia M; Hafner R; Valdespino JL; Coberly J; Schechter M; Klukowicz AJ; Barry MA; O'Brien RJ; Veterans Affairs Medical Center and Georgetown University,; Washington, DC 20422, USA. vawrap@erols.com; CONTEXT: Because of problems with adherence, toxicity, and increasing resistance associated with 6- to 12-month isoniazid regimens, an alternative short-course tuberculosis preventive regimen is needed. OBJECTIVE: To compare a 2-month regimen of daily rifampin and pyrazinamide with a 12-month regimen of daily isoniazi
[Indonesia: the largest archipelago in the world]: Med Trop (Mars). 1999;59(3):229-32. Unique Identifier : AIDSLINE MED/20166024; Lescar S
[Evidence of risk factors for condom breakage among French military personnel stationed overseas]: Med Trop (Mars). 1999;59(3):266-70. Unique Identifier : AIDSLINE MED/20166032; Deparis X; Migliani R; Merlin M; Service de Medecine des Collectivites, l'Institut de Medecine; Tropicale du Service de Sante des Armees, Marseille, France.; medco@gulliver.fr; The French Army Medical Service has been distributing free condoms to overseas personnel since 1989. An epidemiologic study conducted in Cambodia showed that the rate of condom failure during protected sex was 16.3 p. 100. In view this high failure rate, a study to evaluate safet
[Chronic genital ulcerations and HIV infection: 29 cases]: Med Trop (Mars). 1999;59(3):279-82. Unique Identifier : AIDSLINE MED/20166035; Gbery IP; Djeha D; Kacou DE; Aka BR; Yoboue P; Vagamon B; Sangare A; Kanga JM; Centre de Dermatologie et Venereologie, Centre; Hospitalo-Universitaire de Treichville, Abidjan, Cote d'Ivoire.; gbery@africaonlineco.ci; Genital ulcers are common manifestations of infectious disease. The incidence of genital ulcers featuring a chronic course has increased since the beginning of the AIDS epidemic. The purpose of this 18-month cross-sectional study was to determine the main infectious causes of chronic genital ulcers (CGU) and their cor
[Hepatitis C virus: first pathogen found in blood donors in Burundi (letter)]: Med Trop (Mars). 1999;59(3):307. Unique Identifier : AIDSLINE MED/20166040; Ndihokubwayo JB; Ntirandekura D; Nzotungwanayo I; De Lamballerie X
[Risk of Chagas disease through transfusions in the Americans]: Medicina (B Aires). 1999;59 Suppl 2:125-34. Unique Identifier : AIDSLINE MED/20133433; Schmunis GA; Oficina Sanitaria Panamericana/Organizacion Mundial de la Salud,; Washington DC, USA. schmunig@paho.org; The safety of blood transfusion depends on a country s laws, decrees and/or regulations concerning the collection, production and use of blood and blood derivatives. It also needs governmental enforcement of those instruments, as well as trained health professionals to obtain blood and produce blood derivatives, follo
[TH1 response in the experimental infection with Trypanosoma cruzi]: Medicina (B Aires). 1999;59 Suppl 2:84-90. Unique Identifier : AIDSLINE MED/20133427; Cardoni RL; Antunez MI; Abrami AA; Instituto Nacional de Parasitologia Dr. M. Fatala Chaben (INP),; ANLIS Dr. C.G. Malbran, Buenos Aires. rita@inscha.gov.ar; Specific antibodies and the activation of phagocytic cells by IFN-gamma are the key elements of the immune response involved in protection of the T. cruzi infected host. The central role of the IFN-gamma in vivo seems to be the activation of the inducible nitric oxide synthetase of macrophages (iNOS) and the productio
Tissue wasting in patients with chronic obstructive pulmonary disease.: Neurol Clin. 2000 Feb;18(1):245-62. Unique Identifier : AIDSLINE MED/20126214; Farber MO; Mannix ET; Division of Pulmonary, Occupational, and Critical Care Medicine,; Department of Medicine, Indiana University School of Medicine,; Indianapolis , IN 46202, USA.; Malnutrition is common among individuals suffering from hypoxemic chronic obstructive pulmonary disease (COPD), advanced HIV disease, and in patients with chronic, severe congestive heart failure. Although increased morbidity and mortality has been associated with weight loss in these conditions, the pathophysiology o
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group [see comments]: N Engl J Med. 2000 Mar 30;342(13):921-9. Unique Identifier : AIDSLINE MED/20183102; Quinn TC; Wawer MJ; Sewankambo N; Serwadda D; Li C; Wabwire-Mangen F; Meehan MO; Lutalo T; Gray RH; National Institute of Allergy and Infectious Diseases, Bethesda,; MD, USA.; BACKGROUND AND METHODS: We examined the influence of viral load in relation to other risk factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In a community-based study of 15,127 persons in a rural district of Uganda , we identified 415 couples
HTLV-II-associated cutaneous T-cell lymphoma in a patient with HIV-1 infection.: N Engl J Med. 2000 Mar 30;342(13):930-6. Unique Identifier : AIDSLINE MED/20183103; Poiesz B; Dube D; Dube S; Love J; Papsidero L; Uner A; Hutchinson R; Department of Medicine, State University of New York Upstate; Medical University, Syracuse 13210, USA.
Investigators' responsibilities for human subjects in developing countries [editorial; comment]: N Engl J Med. 2000 Mar 30;342(13):967-9. Unique Identifier : AIDSLINE MED/20183108; Angell M
Preventing sexual transmission of HIV--new ideas from sub-Saharan Africa [editorial; comment] [see comments]: N Engl J Med. 2000 Mar 30;342(13):970-2. Unique Identifier : AIDSLINE MED/20183110; Cohen MS
Thalidomide in multiple myeloma [letter]: N Engl J Med. 2000 Mar 30;342(13):975; discussion 975-6. Unique Identifier : AIDSLINE MED/20183112; Kishi Y; Oki Y; Machida U
[Progressive multifocal leukoencephalopathy in AIDS. Overview and retrospective analysis of 17 patients]: Nervenarzt. 2000 Feb;71(2):96-104. Unique Identifier : AIDSLINE MED/20167655; Happe S; Lunenborg N; Rickert CH; Heese C; Reichelt D; Schuierer G; Schul C; Husstedt IW; Klinik und Poliklinik fur Neurologie, Westfalische; Wilhelms-Universitat Munster.; We describe retrospectively the course of 17 AIDS patients with progressive multifocal leukoencephalopathy (PML) and give a review of their clinical symptoms and survival times. The relative frequency of PML in our cohort of AIDS patients was 2.6%. The mean of CD4-positive cells was 80.5 +/- 82.5/microliter. CD4-posit
AIDS- and non-AIDS-related PML association with distinct p53 polymorphism.: Neurology. 2000 Feb 8;54(3):743-6. Unique Identifier : AIDSLINE MED/20143009; Power C; Gladden JG; Halliday W; Del Bigio MR; Nath A; Ni W; Major EO; Blanchard J; Mowat M; Department of Clinical Neurosciences, University of Calgary,; Alberta, Canada.; A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at cod
Cerebellar degeneration associated with HIV infection [letter]: Neurology. 2000 Feb 22;54(4):1012-3. Unique Identifier : AIDSLINE MED/20152871; Sclar G; Kennedy CA; Hill JM; McCormack MK
Cerebrovascular changes in the basal ganglia with HIV dementia.: Neurology. 2000 Feb 22;54(4):921-6. Unique Identifier : AIDSLINE MED/20152846; Berger JR; Nath A; Greenberg RN; Andersen AH; Greene RA; Bognar A; Avison MJ; Department of Neurology, University of Kentucky College of; Medicine, Lexington 40536-2184, USA. jrbneuro@pop.uky.edu; BACKGROUND: HIV dementia is a form of subcortical dementia. Clinical, radiologic, pathologic, and biochemical studies suggest a major contribution of basal ganglia dysfunction to the pathogenesis of this disorder. Many investigators have proposed a contribution of a disrupted blood
Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources.: Neurology. 2000 Feb 22;54(4):927-36. Unique Identifier : AIDSLINE MED/20152847; Ellis RJ; Gamst AC; Capparelli E; Spector SA; Hsia K; Wolfson T; Abramson I; Grant I; McCutchan JA; Department of Neurosciences, HIV Neurobehavioral Research Center,; University of California, San Diego, USA. roellis@ucsd.edu; OBJECTIVE: To identify the sources of HIV virions in CSF by modeling treatment-associated HIV dynamics. BACKGROUND: We postulated a model in which cell-free CSF virions originate from two major sources, namely, systemic non-CNS and CNS tissues, the latter including brain parenchyma and meninges. The model predicted th
Role of brain biopsy in the management of focal brain lesions in HIV-infected patients. Gruppo Italiano Cooperativo AIDS & Tumori.: Neurology. 2000 Feb 22;54(4):993-7. Unique Identifier : AIDSLINE MED/20152862; Antinori A; Ammassari A; Luzzati R; Castagna A; Maserati R; Rizzardini G; Ridolfo A; Fasan M; Vaccher E; Landonio G; Scerrati M; Rocca A; Butti G; Nicolato A; Lazzarin A; Tirelli U; Department of Infectious Diseases, IRCCS L. Spallanzani, Rome,; Italy.; In this multicenter, retrospective study of 160 brain biopsies in the assessment of HIV-related focal brain lesions, diagnostic sensitivity was acceptable (87%), but the procedure carried considerable morbidity (7.5%) and mortality (3.1%). Moreover, it is not always possible to initiate the changes in therapy indicate
International military human immunodeficiency virus/acquired immunodeficiency syndrome policies and programs: strengths and limitations in current practice.: Mil Med. 2000 Feb;165(2):87-92. Unique Identifier : AIDSLINE MED/20174142; Yeager R; Hendrix CW; Kingma S; Department of Political Science, West Virginia University,; Morgantown 26506, USA.; A survey was conducted to evaluate military human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) policies and programs in 119 countries. Ninety-eight percent of the 62 respondents provide prevention education, 95% in group settings but only 53% individually. Predeployment briefings are more commo
An autopsy report of graft-versus-host disease (GVHD) following blood transfusion.: Osaka City Med J. 1999 Jun;45(1):37-43. Unique Identifier : AIDSLINE MED/20188167; Otori K; Masuda C; Wanibuchi H; Nakanishi A; Kawabata K; Ohashi H; Fukushima S; First Department of Pathology, Osaka City University Medical; School, Japan.; A case of graft-versus-host disease (GVHD) associated with blood transfusion in a 71-year-old man is reported. The patient received transfusions (irradiation red cells M.A.P 14 units, fresh frozen plasma 11 units) and developed features of GVHD including fever, a skin rash, diarrhea, liver dysfunction, hypoplastic bon
Cytokine responses of C3H/HeN mice infested with Ixodes scapularis or Ixodes pacificus nymphs.: Parasite Immunol. 2000 Jan;22(1):31-40. Unique Identifier : AIDSLINE MED/20088952; Schoeler GB; Manweiler SA; Wikel SK; Department of Entomology and Plant Pathology, 127 Noble Research; Center, Oklahoma State University, Stillwater, Oklahoma 74078,; USA.; Lyme borreliosis, caused by Borrelia burgdorferi, is transmitted by Ixodes scapularis in the eastern and midwestern United States and by Ixodes pacificus in the far-Western United States. Studies have shown that infestation with I. scapularis nymphs modulates host cytokine production;
CMV in HIV-infected newborns [news]: Pediatr Res. 2000 Feb;47(2):173. Unique Identifier : AIDSLINE MED/20136804; Marodi L
Treatment-resistant expansion of CD8+CD28-cells in pediatric HIV infection.: Pediatr Res. 2000 Mar;47(3):418-21. Unique Identifier : AIDSLINE MED/20172979; Niehues T; Horneff G; Knipp S; Adams O; Wahn V; Department of Pediatrics, Heinrich Heine University, Dusseldorf,; Germany.; There is a disease stage-dependent loss of CD28 expression on T cells in HIV-infected children. In this study, T cell recovery, in particular CD28 expression on T cells, was analyzed after initiation of highly active antiretroviral therapy in a group of eight mostly treatment-naive HIV-infected children. Plasma HIV-RN
Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2.: Unique Identifier : AIDSLINE MED/20115930 P
Multiple copies of the Mason-Pfizer monkey virus constitutive RNA transport element lead to enhanced HIV-1 Gag expression in a context-dependent manner.: Nucleic Acids Res. 2000 Feb 15;28(4):901-10. Unique Identifier : AIDSLINE MED/20115916; Wodrich H; Schambach A; Krausslich HG; Heinrich-Pette-Institut fur experimentelle Virologie und; Immunologie an der Universitat Hamburg, Martinstrasse 52,; D-20251 Hamburg, Germany.; Retroviral gene expression requires nuclear export and translation of incompletely spliced RNA. In the case of human immunodeficiency virus (HIV), this is facilitated by the viral Rev protein binding to its cognate RNA response element (RRE), while other retroviruses contain constitutive transport elements (CTE) bindi
Prediction of common secondary structures of RNAs: a genetic algorithm approach.: Nucleic Acids Res. 2000 Feb 15;28(4):991-9. Unique Identifier : AIDSLINE GENBANK/M31113; Chen JH; Le SY; Maizel JV; Advanced Biomedical Computing Center, SAIC, NCI/FCRDC, Frederick,; MD 21702, USA. chen@ncifcrf.gov; In this study we apply a genetic algorithm to a set of RNA sequences to find common RNA secondary structures. Our method is a three-step procedure. At the first stage of the procedure for each sequence, a genetic algorithm is used to optimize the structures in a population to a certain degree of stability. In this ste
Antiviral therapy for chronic hepatitis B and C. Which patients are likely to benefit from which agents?: Postgrad Med. 2000 Feb;107(2):135-8, 141-4. Unique Identifier : AIDSLINE MED/20154003; Gordon SC; Division of Gastroenterology-Hepatology, William Beaumont; Hospital, Royal Oak, Michigan 48073-6769, USA.; sgordon@beaumont.edu; As primary care physicians become increasingly involved in diagnosis and treatment of patients with chronic viral hepatitis, an understanding of the antiviral options available, their limitations, and their side effects takes on a special importance. For chronic HBV infection, interferon alfa-2b requires only a 4-mont
Sexually transmitted diseases in women. Gonorrhea and syphilis.: Postgrad Med. 2000 Feb;107(2):181-4, 189-90, 193-7. Unique Identifier : AIDSLINE MED/20154006; Emmert DH; Kirchner JT; Department of Family and Community Medicine, Lancaster General; Hospital, PA 17604-3555, USA.; Gonorrhea has been declining since its 1975 peak. Risk factors include age 15 to 19 years, multiple or casual sexual contacts, sexual activity related to drug use, and low socioeconomic status. Infection is usually mild but may be asymptomatic. While no physical signs are specific to the gonococcus, pelvic inflammator
[AIDS: new FDA approved agents (news)]: Pharm Unserer Zeit. 2000 Jan;29(1):58. Unique Identifier : AIDSLINE MED/20166141; Forstenlehner M
Screening of selected plant extracts for in vitro inhibitory activity on HIV-1 reverse transcriptase (HIV-1 RT).: Pharmazie. 2000 Jan;55(1):75-7. Unique Identifier : AIDSLINE MED/20147502; Mlinaric A; Kreft S; Umek A; Strukelj B; Department of Pharmaceutical Biology, Faculty of Pharmacy,; University of Ljubljana, Slovenia.; Methanolic-aqueous extracts of 70 plants were investigated for their ability to inhibit HIV-1 reverse transcriptase activity in vitro. Two thirds of the extracts screened showed more than 50% inhibition. Two extracts inhibited the enzyme completely while four exhibited more than 90% inhibition. Tannins as nonspecific
International union of pharmacology. XXII. Nomenclature for chemokine receptors.: Pharmacol Rev. 2000 Mar;52(1):145-76. Unique Identifier : AIDSLINE MED/20164997; Murphy PM; Baggiolini M; Charo IF; Hebert CA; Horuk R; Matsushima K; Miller LH; Oppenheim JJ; Power CA; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. pmm@nih.gov; Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled receptors differentially expressed in diverse cell types. Biological activities have been most clearly defined in leukocytes, where chemokines coordinate development, differentiation, anatomic distribution, trafficking, and eff
[Serial assessment of the nutritional status of patients infected by the human immunodeficiency virus. Role of tumor necrosis factor/its receptors]: Rev Clin Esp. 1999 Dec;199(12):790-5. Unique Identifier : AIDSLINE MED/20152027; Segura Fernandez E; Domenech Cienfuegos I; Perez Guzman E; Guerrero Sanchez F; Escribano Moriana JC; Perez Cano R; Fernandez-Gutierrez del Alamo C; Giron Gonzalez JA; Servicio de Medicina Interna, Hospital Universitario Puerta del; Mar, Facultad de Medicina, Cadiz.; In order to analyze the nutritional status of HIV infected patients and the involvement of the tumour necrosis factor-alpha (TNF-alpha) and its soluble receptors (sTNFRI and sTNFRII) in such an status, forty HIV infected patients, with no associated systemic opportunist infections, were prospectively followed for eigh
[Lung nodules in a patient with HIV infection and severe neutropenia]: Rev Clin Esp. 1999 Dec;199(12):849-50. Unique Identifier : AIDSLINE MED/20152037; de Dios Perrino S; Alonso Claudio G; Arevalo Velasco A; Santos de Vega G; Fuertes Martin A; Jimenez Lopez A; Servicio de Medicina Interna II, Hospital Universitario,; Salamanca.
[Thrombocytopenic thrombotic purpura, HIV, and antiviral therapy (letter)]: Rev Clin Esp. 1999 Dec;199(12):859-60. Unique Identifier : AIDSLINE MED/20152044; Valencia Ortega ME; Gil Aguado A; Lavilla Uriol P; Gonzalez Lahoz J
[Arthritis and tenosynovitis caused by Mycobacterium kansasii associated with human immunodeficiency virus infection (letter)]: Rev Clin Esp. 1999 Dec;199(12):863. Unique Identifier : AIDSLINE MED/20152048; Pintado V; Antela A; Corres J; Martin-Davila P
[Nevirapine induces abstinence symptoms in patients on a methadone maintenance program with HIV infection]: Rev Clin Esp. 2000 Jan;200(1):12-4. Unique Identifier : AIDSLINE MED/20186061; Bano Rodrigo MD; Agujetas Rodriguez M; Lopez Garcia ML; Guillen Llera JL; Programa Municipal de Drogas de Majadahonda, Escuela de; especializacion de analisis clinicos, Facultad de Farmacia,; Universidad Complutense, Madrid.; The objective of this study was to investigate the potential inductive effect of nevirapine (NVP) with methadone. Eight patients on the methadone maintenance programme with anti-retroviral therapy because of their infection with HIV, well maintained w
[An intracranial mass in a patient with HIV infection]: Rev Clin Esp. 2000 Jan;200(1):33-4. Unique Identifier : AIDSLINE MED/20186067; Crespo Valades E; Vera Tome A; Diaz Pinto P; Sanchez Montero F; Munoz Sanz A; Unidad de Enfermedades Infecciosas, Hospital Regional; Universitario Infanta Cristina, Badajoz.
Simultaneous serological evidence of Actinobacillus pleuropneumoniae, PRRS, Aujeszky's disease and influenza viruses in Spanish finishing pigs.: Res Vet Sci. 2000 Feb;68(1):9-13. Unique Identifier : AIDSLINE MED/20150297; Gutierrez-Martin CB; Rodriguez-Delgado O; Alvarez-Nistal D; De La Puente-Redondo VA; Garcia-Rioja F; Martin-Vicente J; Rodriguez Ferri EF; Microbiology and Immunology Section. Department of Animal Health.; Faculty of Veterinary Medicine, University of Leon, 24071 -; Leon, Spain.; A total of 198 pigs with tachypnoea and temperature >/= 40 degrees C were selected on a Spanish finishing unit, and their sera were examined for antibodies to Actinobacillus pleuropneumoniae (App), porcine reproductive and respiratory syndrome virus (PRRSV), Aujeszky disease virus (ADV), and swine influenza virus (SI
Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts.: Semin Diagn Pathol. 2000 Feb;17(1):56-65. Unique Identifier : AIDSLINE MED/20184832; Adsay NV; Hasteh F; Cheng JD; Klimstra DS; Department of Pathology, The Karmanos Cancer Institute-Detroit; Medical Center, Wayne State University, MI 48076, USA.; adsayv@med.wayne.edu; In the pancreas, 3 types of morphologically similar lesions may present as squamous cysts : Lymphoepithelial cysts, dermoid cysts (monodermal teratomas), and epidermoid cysts in intrapancreatic accessory spleen. Lymphoepithelial cysts (LECs) are seen predominantly in men (M/F: 4/1) and in adulthood (mean age, 56, and
[The general medical importance of oral health. The 5th Annual Meeting of the Swiss Association for Preventive and Restorative Dentistry (SVPR) of 13 November 1999 in Zurich]: Schweiz Monatsschr Zahnmed. 2000;110(2):211-2. Unique Identifier : AIDSLINE MED/20205587; Gruninger A
Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.: Science. 2000 Mar 24;287(5461):2274-7. Unique Identifier : AIDSLINE MED/20196025; Faure S; Meyer L; Costagliola D; Vaneensberghe C; Genin E; Autran B; Delfraissy JF; McDermott DH; Murphy PM; Debre P; Theodorou I; Combadiere C; Laboratoire d'Immunologie Cellulaire et Tissulaire, Centre; National de la Recherche Scientifique UMR 7627, Hopital; Pitie-Salpetriere, Paris, France.; Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor a
Antenatal HIV screening--knowledge, attitudes and practices of obstetricians in KKH.: Singapore Med J. 1999 Dec;40(12):733-7. Unique Identifier : AIDSLINE MED/20174198; Tan TY; Teo KP; Tan KH; Department of Maternal-Fetal Medicine, KK Women's and Children's; Hospital, Singapore.; AIM OF STUDY: To determine the knowledge, attitudes and practices of obstetricians with regards to HIV screening in pregnant women. METHOD: This is a cross-sectional study based on a questionnaire survey of all obstetricians in KKH from January to August 1997. MAIN OUTCOME MEASURES: Obstetricians knowledge and belief
Health and disease in southern Africa: a comparative and vulnerability perspective.: Soc Sci Med. 2000 Apr;50(7-8):965-83. Unique Identifier : AIDSLINE MED/20177402; Kalipeni E; Department of Geography, University of Illinois at; Urbana-Champaign, Urbana 61801, USA. kalipeni@uiuc.edu; Using a vulnerability and comparative perspective, this paper examines the status of health in southern Africa highlighting the disease complex and some of the factors for the deteriorating health conditions. It is argued that aggregate social and health care indicators for the region such as life expectancy and infan
Disclosure of HIV status and its consequences [letter]: S Afr Med J. 1999 Dec;89(12):1238. Unique Identifier : AIDSLINE MED/20142672; Mathews C; Kuhn L; Fransman D; Hussey G; Dikweni L
HIV seropositivity in the Western Cape [letter]: S Afr Med J. 1999 Dec;89(12):1239. Unique Identifier : AIDSLINE MED/20142673; Edge J; van der Merwe AE
AZT--the saga continues [news]: S Afr Med J. 1999 Dec;89(12):1244-5. Unique Identifier : AIDSLINE MED/20142677; Simon-Meyer J
Clinical progression of HIV infection in adults.: S Afr Med J. 1999 Dec;89(12):1255-8. Unique Identifier : AIDSLINE MED/20142681; Maartens G; Department of Medicine, University of Cape Town.
Microbiologically proven Pneumocystis carinii pneumonia (PCP) at Ga-Rankuwa Hospital [letter]: S Afr Med J. 1999 Dec;89(12):1274-5. Unique Identifier : AIDSLINE MED/20142686; Sein PP; Hoosen AA; Mzileni MO
Intracranial mass lesions in HIV-positive patients--the KwaZulu/Natal experience. Neuroscience AIDS Research Group.: S Afr Med J. 1999 Dec;89(12):1284-8. Unique Identifier : AIDSLINE MED/20142689; Bhigjee AI; Naidoo K; Patel VB; Govender D; Department of Neurology, Wentworth Hospital, Durban.; BACKGROUND: Neurological disease heralds the development of AIDS in 10-20% of HIV-seropositive individuals. In over half of these cases the presentation will be that of an intracranial mass lesion (IML). In developed countries toxoplasmosis is the most frequent cause of IML in a positive patient, followed by primary c
Management of opportunist mycobacterial infections: Joint Tuberculosis Committee Guidelines 1999. Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society.: Thorax. 2000 Mar;55(3):210-8. Unique Identifier : AIDSLINE MED/20146100
Expression of human immunodeficiency virus type 1 Gag protein precursor and envelope proteins from a vesicular stomatitis virus recombinant: high-level production of virus-like particles containing HIV envelope.: Virology. 2000 Mar 1;268(1):112-21. Unique Identifier : AIDSLINE MED/20149227; Haglund K; Forman J; Krausslich HG; Rose JK; Department of Pathology, Yale University School of Medicine, New; Haven, Connecticut, 06510, USA.; Recombinant vesicular stomatitis viruses have been developed as high-level expression vectors which serve as effective vaccine vectors in animals (Roberts et al., 1998, J. Virol. 72, 4704-4711; Roberts et al., 1999, J. Virol. 73, 3723-3732). Here we show that two genes can be expressed simultaneously from a single, li
Peripheral blood mononuclear cells of HIV- and HCV-antibody-positive individuals contain HCV RNA but No HCV DNA despite evidence for reverse transcription of HIV RNA into DNA.: Virology. 2000 Mar 1;268(1):12-6. Unique Identifier : AIDSLINE MED/20149216; Penning M; Beld M; Goudsmit J; Department of Human Retrovirology, University of Amsterdam,; Amsterdam, The Netherlands.; Following reports of the finding of cDNA of RNA viruses in cells containing an endogenous retrovirus-encoded reverse transcriptase, we looked for the presence of hepatitis C virus (HCV) DNA in peripheral blood mononuclear cells (PBMC) of injecting drug users seropositive for both HCV and human immunodefiency virus (HI
Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens.: Unique Identifier : AIDSLINE MED/20149228; Kovarik J; Martinez X; Pihlgren M; Bozzotti P; Tao MH; Kipps TJ; Wild TF; Lambert PH; Siegrist CA; World Health Organization Collaborating Centre for Neonatal; Vaccinology, University of Geneva Medical School, Geneva,; Switzerland. jiri.kovarik@medecine.unige.ch; The limited induction of Th1 and cytotoxic immune responses is regarded as the main reason for the increased susceptibility to intracellular microorganisms in early life. Recently, in vitro IL-12 supplementation was shown to enhance the limited IFN-gamma release of measles-specific infant T cells. Using a series of IL
Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immunodeficient mouse strains.: Virology. 2000 Mar 1;268(1):17-28. Unique Identifier : AIDSLINE MED/20149217; Ellison AR; Yang L; Voytek C; Margolis TP; Francis I. Proctor Foundation, Department of Ophthalmology,; University of California at San Francisco Medical Center, 95; Kirkham Street, San Francisco, California, 94143, USA.; Productive infection with herpes simplex virus (HSV) type 1 is limited by both innate and adaptive immune mechanisms. The purpose of the current study was to determine whether these mechanisms also play a role in the establishment of latent HSV infection. First we examined the trigeminal ganglia (TG) of severe combine
Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus.: Virology. 2000 Mar 1;268(1):201-17. Unique Identifier : AIDSLINE MED/20149236; Cinquina CC; Grogan E; Sun R; Lin SF; Beardsley GP; Miller G; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut, 06520, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is the first human virus known to encode dihydrofolate reductase (DHFR), an enzyme required for nucleotide and methionine biosynthesis. We have studied the purified KSHV-DHFR enzyme in vitro and analyzed its expression in cultured B-cell lines derived from primary effusio
The HTLV receptor is a widely expressed protein.: Virology. 2000 Mar 1;268(1):41-8. Unique Identifier : AIDSLINE MED/20149219; Trejo SR; Ratner L; Washington University School of Medicine, St. Louis, Missouri,; 63110, USA.; The receptor for human T-cell leukemia virus type 1 (HTLV-1) was found to be expressed on a broad range of cell lines derived from multiple species. Receptor expression was assessed using human immunodeficiency virus type 1 particles, pseudotyped with the HTLV-1 envelope glycoprotein, and expressing luciferase under t
Canine cyclin T1 rescues equine infectious anemia virus tat trans-activation in human cells.: Virology. 2000 Mar 1;268(1):7-11. Unique Identifier : AIDSLINE MED/20149215; Albrecht TR; Lund LH; Garcia-Blanco MA; Department of Genetics, Duke University Medical Center, Durham,; North Carolina, 27710, USA.; Human immunodeficiency virus-1 Tat protein and human Cyclin T1 mediate transcriptional activation by enhancing the elongation efficiency of RNA polymerase II. Activation of transcription of the related equine infectious anemia virus (EIAV) requires a similar protein known as eTat, which does not function in human cell
Construction of a selectable nef-defective live-attenuated human immunodeficiency virus expressing Escherichia coli gpt gene.: Unique Identifier : AIDSLINE MED/20149223; Tanuri A; Jesus da Costa L; Brindeiro R; Ramos CA; Pau CP; Rayfield MA; We have developed a replication-competent human immunodeficiency virus (HIV) carrying a selective marker that can be used in vivo. This recombinant virus (Z6 Delta nef gpt) was generated by replacing the 5 half of the HIV nef gene with the Escherichia coli guanine phosphoribosyl transferase gene (gpt). This new vecto
The kinetics of specific immune responses in rhesus monkeys inoculated with live recombinant BCG expressing SIV Gag, Pol, Env, and Nef proteins.: Virology. 2000 Mar 1;268(1):94-103. Unique Identifier : AIDSLINE MED/20149225; Leung NJ; Aldovini A; Young R; Jarvis MA; Smith JM; Meyer D; Anderson DE; Carlos MP; Gardner MB; Torres JV; Department of Medical Microbiology, School of Medicine,; University of California, Davis, California, 95616, USA.; Development of an effective preventive or therapeutic vaccine against HIV-1 is an important goal in the fight against AIDS. Effective virus clearance and inhibition of spread to target organs depends principally on the cellular immune response. Therefore, a vaccine against HIV-1 should elicit virus-specific cytotoxic
Vitamin E and immunity.: Vitam Horm. 2000;59:305-36. Unique Identifier : AIDSLINE MED/20178592; Moriguchi S; Muraga M; Department of Nutrition, Faculty of Human Life Science, Yamaguchi; Prefectural University, Japan.; Vitamin E is a potent antioxidant and has an ability to modulate host immune functions. This chapter consists of five parts: (1) vitamin E deficiency and immunity, (2) vitamin E supplementation and immunity, (3) vitamin E and the decreased cellular immunity with aging, (4) vitamin E and T-cell differentiation in the t
Bloodborne viruses in forensic medical practice in South Africa.: Am J Forensic Med Pathol. 1999 Dec;20(4):364-8. Unique Identifier : AIDSLINE MED/20088269; du Plessis R; Webber L; Saayman G; Department of Forensic Medicine, Institute of Pathology,; University of Pretoria, Republic of South Africa.; rdplessi@medic.up.co.za; Health care workers are at risk of exposure to bloodborne viruses including human immunodeficiency virus types 1 and 2 (HIV-1 and 2), hepatitis B virus (HBV) and hepatitis C virus (HCV). However, limited data is available regarding these risks to forensic medical personnel who are exposed daily to large numbers of sev
Reactivation of hepatitis B in patients with human immunodeficiency virus infection treated with combination antiretroviral therapy.: Am J Med. 2000 Feb 15;108(3):249-51. Unique Identifier : AIDSLINE MED/20186530; Proia LA; Ngui SL; Kaur S; Kessler HA; Trenholme GM; Section of Infectious Diseases, Rush Presbyterian-St Luke's; Hospital, Chicago, Illinois 60612, USA.
Fungal flora on cutaneous and mucosal surfaces of cats infected with feline immunodeficiency virus or feline leukemia virus.: Am J Vet Res. 2000 Feb;61(2):158-61. Unique Identifier : AIDSLINE MED/20148123; Sierra P; Guillot J; Jacob H; Bussieras S; Chermette R; Equipe de Parasitologie-Mycologie, UMR INRA-AFSSA-ENVA Biologie; Moleculaire et Immunologie Parasitaires et Fongiques, Ecole; Nationale Veterinaire dAlfort, Maisons-Alfort, France.; OBJECTIVE: To compare cutaneous and mucosal mycoflora in cats infected with FIV or FeLV with that in noninfected cats. ANIMALS: 85 client-owned cats; 24 seropositive for FIV, 10 seropositive for FeLV, 1 seropositive for both viruses, and 50 seronegative for both viruses. PROCEDURE: Cutaneous specimens were obtained fr
Lamivudine-associated remission of chronic hepatitis delta [letter]: Ann Intern Med. 2000 Apr 4;132(7):598. Unique Identifier : AIDSLINE MED/20186700; Andreone P; Spertini F; Negro F
Modulation of glutathione synthetic enzymes by acidic fibroblast growth factor.: Arch Biochem Biophys. 2000 Mar 1;375(1):201-9. Unique Identifier : AIDSLINE MED/20148381; Choi J; Opalenik SR; Wu W; Thompson JA; Forman HJ; Department of Molecular Pharmacology, University of Southern; California School of Pharmacy, Los Angeles, California, 90033,; USA.; Increasing evidence suggests that glutathione (GSH) synthesis is a regulated process. Documented increases in gamma-glutamylcysteine synthetase (GCS) occur in response to oxidants, in tumors, on plating cells at a low cell density, and with nerve growth factor stimulation, suggesting that GSH synthesis may be related
Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? [see comments]: Arch Dermatol. 2000 Mar;136(3):323-7. Unique Identifier : AIDSLINE MED/20186788; Garcia-Doval I; LeCleach L; Bocquet H; Otero XL; Roujeau JC; Department of Dermatology, Hospital Provincial de Pontevedra,; Spain.; BACKGROUND: Withdrawal of the drug(s) that cause severe cutaneous adverse reactions is usually recommended without proof that it alters the course of those reactions. OBJECTIVE: To determine whether the timing of causative drug withdrawal is related to the prognosis of patients with toxic epidermal necrolysis (TEN) or
Cutaneous aspergillosis and acquired immunodeficiency syndrome [see comments]: Arch Dermatol. 2000 Mar;136(3):365-9. Unique Identifier : AIDSLINE MED/20186793; Murakawa GJ; Harvell JD; Lubitz P; Schnoll S; Lee S; Berger T; Department of Dermatology, University of California, San; Francisco, USA. murakag@mail.amc.edu; BACKGROUND: Primary cutaneous aspergillosis is an uncommon finding in patients with acquired immunodeficiency syndrome (AIDS); only 13 cases have been reported in the literature. OBSERVATIONS: We describe 11 patients with primary cutaneous aspergillosis and AIDS. There does not seem to be an age, sex, race, or human i
Human immunodeficiency virus infection and cutaneous aspergillosis [editorial; comment]: Arch Dermatol. 2000 Mar;136(3):412-4. Unique Identifier : AIDSLINE MED/20186803; Roilides E; Farmaki E
Does an infected peripancreatic fluid collection or abscess mandate operation?: Ann Surg. 2000 Mar;231(3):361-7. Unique Identifier : AIDSLINE MED/20177111; Baril NB; Ralls PW; Wren SM; Selby RR; Radin R; Parekh D; Jabbour N; Stain SC; Department of Surgery, University of Southern California School; of Medicine, Los Angeles, USA.; OBJECTIVE: To assess the treatment of peripancreatic fluid collections or abscess with percutaneous catheter drainage (PCD). SUMMARY BACKGROUND DATA: Surgical intervention has been the mainstay of treatment for infected peripancreatic fluid collections and abscesses. Increasingly, PCD has been used, with mixed results
Cardiac manifestations of acquired immunodeficiency syndrome.: Unique Identifier : AIDSLINE MED/20186612; Rerkpattanapipat P; Wongpraparut N; Jacobs LE; Kotler MN; Acquired immunodeficiency syndrome is a serious problem
The effect of acute severe illness on CD4+ lymphocyte counts in nonimmunocompromised patients [letter]: Arch Intern Med. 2000 Mar 13;160(5):715-6. Unique Identifier : AIDSLINE MED/20186630; Aldrich J; Gross R; Adler M; King K; MacGregor RR; Gluckman SJ
Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin and its derivatives with triazole.: Arzneimittelforschung. 2000 Jan;50(1):55-9. Unique Identifier : AIDSLINE MED/20147341; Pandeya SN; Sriram D; Nath G; de Clercq E; Department of Pharmaceutics, Banaras Hindu University, Varanasi,; India. snpande@banaras.ernet.in; Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4 -pyridyl)-4-amino-5-mercapto-4-(H)-1,2,4-triazole to form Schiff bases and the N-Mannich bases of these compounds were synthesised by reacting them with formaldehyde and several secondary amines. Their chemical structures ha
A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.: AIDS. 2000 Feb 18;14(3):F25-32. Unique Identifier : AIDSLINE MED/20179239; Carr A; Miller J; Law M; Cooper DA; HIV, Immunology and Infectious Diseases Clinical Services Unit,; St Vincent's Hospital, University of New South Wales, Sydney,; Australia. acarr@stvincents.com.au; BACKGROUND: Lipodystrophy (LD; peripheral lipoatrophy, central adiposity) hyperlipidaemia and insulin resistance often complicate protease inhibitor-containing antiretroviral therapy. Lipoatrophy and abdominal distension were observed in protease inhibitor-naive nucleoside analogue reverse transcriptase inhibitor (NRT
HIV-1 strains from a cohort of American subjects reveal the presence of a V2 region extension unique to slow progressors and non-progressors.: AIDS. 2000 Feb 18;14(3):213-23. Unique Identifier : AIDSLINE MED/20179240; Wang B; Spira TJ; Owen S; Lal RB; Saksena NK; Retroviral Genetics Laboratory, Center for Virus Research,; Westmead Hospital, University of Sydney, Australia.; OBJECTIVES: To determine the molecular nature of HIV-1 quasispecies and their evolution, in vivo over time, in an American cohort of 22 homosexual men [four rapid progressors (RP), 15 slow progressors (SP) and three long-term non-progressors (LTNP)], infected with HIV-1 between 1982 and 1983, and to assess the possibl
Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection.: AIDS. 2000 Feb 18;14(3):225-33. Unique Identifier : AIDSLINE MED/20179241; Wilson JD; Ogg GS; Allen RL; Davis C; Shaunak S; Downie J; Dyer W; Workman C; Sullivan S; McMichael AJ; Rowland-Jones SL; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, UK.; OBJECTIVE: HIV-specific cytotoxic T lymphocytes (CTL) are believed to play an important role in containing viral replication throughout HIV-1 infection. Previous studies have attempted to quantify the HIV-1-specific CTL precursor frequency during primary HIV infection by using limiting dilution analysis, which almost
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors [editorial; comment]: AIDS. 2000 Feb 18;14(3):235-6. Unique Identifier : AIDSLINE MED/20179242; Clayette P; Jorajuria S; Dormont D
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors [editorial] [see comments]: AIDS. 2000 Feb 18;14(3):237-42. Unique Identifier : AIDSLINE MED/20179243; Huisman MT; Smit JW; Schinkel AH
Time of initiation of antiretroviral therapy: impact on HIV-1 viraemia. The Swiss HIV Cohort Study.: AIDS. 2000 Feb 18;14(3):243-9. Unique Identifier : AIDSLINE MED/20179244; Yerly S; Kaiser L; Perneger TV; Cone RW; Opravil M; Chave JP; Furrer H; Hirschel B; Perrin L; Laboratory of Virology, Geneva University Hospital, Switzerland.; OBJECTIVE: The current recommendation that patients infected with HIV-1 be treated early is based on little evidence. We examined whether the early initiation of antiretroviral treatment affects residual HIV-1 viraemia. METHODS: Viraemia was measured using an assay with a detection limit of 3 HIV-1 RNA copies/ml in dr
Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume.: AIDS. 2000 Feb 18;14(3):251-61. Unique Identifier : AIDSLINE MED/20179245; Vigano A; Vella S; Saresella M; Vanzulli A; Bricalli D; Di Fabio S; Ferrante P; Andreotti M; Pirillo M; Dally LG; Clerici M; Principi N; Pediatric Department IV, University of Milan, Ospedale Luigi; Sacco, Italy. alevig@mailserver.unimi.it; DESIGN: Despite significant rises in total CD4 T cells, the process of immune reconstitution in adults with HIV infection treated with potent antiretroviral treatment results in a rather slow increase in phenotypically naive lymphocytes. In children more than in adults, thymic function may be at least partly restored
HIV-1 genotypic zidovudine drug resistance and the risk of maternal--infant transmission in the women and infants transmission study. The Women and Infants Transmission Study Group.: AIDS. 2000 Feb 18;14(3):263-71. Unique Identifier : AIDSLINE MED/20179246; Welles SL; Pitt J; Colgrove R; McIntosh K; Chung PH; Colson A; Lockman S; Fowler MG; Hanson C; Landesman S; Moye J; Rich KC; Zorrilla C; Japour AJ; Division of Epidemiology, University of Minnesota, School of; Public Health, Minneapolis 55454, USA. welles@epi.umn.edu; OBJECTIVES: Although the treatment of pregnant women and their infants with zidovudine (ZDV) has been remarkably effective in preventing the perinatal transmission of human HIV-1, many potentially preventable infections still occur. To examine whether the risk of perinatal infection is increased among women who carry
Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea.: AIDS. 2000 Feb 18;14(3):273-8. Unique Identifier : AIDSLINE MED/20179247; Moore RD; Wong WM; Keruly JC; McArthur JC; Johns Hopkins University School of Medicine, Baltimore, Maryland; 21205, USA.; BACKGROUND: Sensory neuropathy is a common adverse effect of the nucleoside analogue anti-retroviral drugs didanosine (ddl) and stauvudine ( d4T ). These drugs are increasingly being used in combination, and it is not currently known whether the inciden
Geographic variation of HIV infection in childbearing women with syphilis in the United States.: AIDS. 2000 Feb 18;14(3):279-87. Unique Identifier : AIDSLINE MED/20179248; Koumans EH; Sternberg M; Gwinn M; Swint E; Zaidi A; St Louis ME; Division of STD Prevention, Centers for Disease Control, Atlanta,; Georgia 30333, USA.; OBJECTIVES: Substantial biologic and epidemiologic data indicate the importance of syphilis as a potential cofactor for sexual transmission of HIV infection, but few detailed data exist on the geographic covariation of these two important sexually transmitted infections. DESIGN: HIV prevalence in childbearing women an
HIV-1 diversity in France, 1996-1998. The AC 11 laboratory network.: AIDS. 2000 Feb 18;14(3):289-96. Unique Identifier : AIDSLINE MED/20179249; Couturier E; Damond F; Roques P; Fleury H; Barin F; Brunet JB; Brun-Vezinet F; Simon F; European Centre for the Epidemiological Monitoring of AIDS,; Hopital National de Saint-Maurice, France.; OBJECTIVE: To study the distribution of HIV-1 subtypes in France and to describe the characteristics of patients infected with non-B subtypes. METHODS: All adults who tested HIV-1 positive on Western blot for the first time in one of the participating laboratories between September
Behavioral and biologic evidence of persistent high-risk behavior in an HIV primary care population.: AIDS. 2000 Feb 18;14(3):297-301. Unique Identifier : AIDSLINE MED/20179250; Erbelding EJ; Stanton D; Quinn TC; Rompalo A; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: To define the prevalence of gonorrhea, chlamydial infection, and high-risk sexual behavior in an HIV primary care clinic. DESIGN: Subjects enrolling in this cross-sectional study answered a brief interviewer-administered questionnaire and provided a urine sample for gonorrhea and chlamydia testing. SETTING:
Comparison of sexual behaviors, unprotected sex, and substance use between two independent cohorts of gay and bisexual men.: AIDS. 2000 Feb 18;14(3):303-11. Unique Identifier : AIDSLINE MED/20179251; Craib KJ; Weber AC; Cornelisse PG; Martindale SL; Miller ML; Schechter MT; Strathdee SA; Schilder A; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To compare demographic characteristics, sexual practices, unprotected receptive and insertive anal intercourse, substance use and rates of HIV-1 seroconversion between two prospective cohorts of HIV-negative men who have sex with men. DESIGN: Comparative analysis of two independent cohorts. METHODS: Between
The prevalence and incidence of HIV-1 infection and syphilis in a cohort of police officers in Dar es Salaam, Tanzania: a potential population for HIV vaccine trials.: AIDS. 2000 Feb 18;14(3):313-20. Unique Identifier : AIDSLINE MED/20179252; Bakari M; Lyamuya E; Mugusi F; Aris E; Chale S; Magao P; Jossiah R; Janabi M; Swai A; Pallangyo N; Sandstrom E; Mhalu F; Biberfeld G; Pallangyo K; Muhimbili University College of Health Sciences, Dar es Salaam,; Tanzania.; OBJECTIVES: To assess the suitability of a cohort of police officers in Dar es Salaam for HIV vaccine trials by determining the prevalence and incidence of HIV-1 infection, active syphilis and their associated factors. Design and setting: An open cohort study of police officers in Dar es Salaam,
Epidemiology of thrombosis in HIV-infected individuals. The Adult/Adolescent Spectrum of HIV Disease Project.: AIDS. 2000 Feb 18;14(3):321-4. Unique Identifier : AIDSLINE MED/20179253; Sullivan PS; Dworkin MS; Jones JL; Hooper WC; Division of HIV/AIDS Prevention, National Center for Infectious; Diseases, Atlanta, Georgia 30333, USA. pss0@cdc.gov; OBJECTIVE: To describe the incidence of clinically recognized thrombosis and associated factors among individuals infected with HIV. DESIGN: A longitudinal medical record review. SETTING: Over 100 medical clinics in nine US cities. PATIENTS: A total of 42 935 individuals aged 13 years or older with HIV infection, obse
Is post-exposure prophylaxis affordable? [letter; comment]: AIDS. 2000 Feb 18;14(3):325. Unique Identifier : AIDSLINE MED/20179254; Pinkerton SD; Holtgrave DR; Kahn JG
A reality check: the cost of making post-exposure prophylaxis available to gay and bisexual men at high sexual risk [letter] [see comments]: AIDS. 2000 Feb 18;14(3):325-6. Unique Identifier : AIDSLINE MED/20179255; Low-Beer S; Weber AE; Bartholomew K; Landolt M; Oram D; Montaner JS; O'Shaughnessy MV; Hogg RS
Diversity of HIV-1 genetic subtypes in France, in the context of mother-to-child transmission. The French Pediatric Cohort Study Group [letter]: AIDS. 2000 Feb 18;14(3):327-8. Unique Identifier : AIDSLINE MED/20179256; Chaix ML; Manigart O; Letourneur F; Burgard M; Mayaux MJ; Rouzioux C
HIV virions and HIV replication are unaffected by granulysin [letter]: AIDS. 2000 Feb 18;14(3):328-30. Unique Identifier : AIDSLINE MED/20179257; Mackewicz CE; Ridha S; Levy JA
Normalization of the CD4 T cell receptor repertoire after evolution of syncytium-inducing HIV-1 variants [letter]: AIDS. 2000 Feb 18;14(3):330-1. Unique Identifier : AIDSLINE MED/20179258; Kostense S; Krop E; Blaak H; Schuitemaker H; Miedema F
Efavirenz associated with corticosteroids in patients with previous severe hypersensitivity reaction due to nevirapine [letter]: AIDS. 2000 Feb 18;14(3):331-2. Unique Identifier : AIDSLINE MED/20179259; Podzamczer D; Consiglio E; Ferrer E; Gudiol F
Excess peripheral neuropathy in patients treated with hydroxyurea plus didanosine and stavudine for HIV infection [letter]: AIDS. 2000 Feb 18;14(3):332-3. Unique Identifier : AIDSLINE MED/20179260; Cepeda JA; Wilks D
Relationship between Kaposi's sarcoma, Kaposi's sarcoma-associated herpesvirus and AIDS dementia complex [letter]: AIDS. 2000 Feb 18;14(3):333-5. Unique Identifier : AIDSLINE MED/20179261; Dupin N; Marcelin AG; Caumes E; Barete S; Arkoub ZA; Bossi P; Agher R; Calvez V
Rash as side-effect of nelfinavir in children [letter]: AIDS. 2000 Feb 18;14(3):335-6. Unique Identifier : AIDSLINE MED/20179262; Fortuny C; Vicente MA; Medina MM; Gonzalez-Ensenat A
Carpal tunnel syndrome in HIV-1 patients: a metabolic consequence of protease inhibitor use? [letter]: AIDS. 2000 Feb 18;14(3):336-8. Unique Identifier : AIDSLINE MED/20179263; Sclar G
Continuous low dose Thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer.: Br J Cancer. 2000 Feb;82(4):812-7. Unique Identifier : AIDSLINE MED/20194889; Eisen T; Boshoff C; Mak I; Sapunar F; Vaughan MM; Pyle L; Johnston SR; Ahern R; Smith IE; Gore ME; Department of Medicine, Royal Marsden Hospital, London, UK.; To grow and metastasize, solid tumours must develop their own blood supply by neo-angiogenesis. Thalidomide inhibits the processing of mRNA encoding peptide molecules including tumour necrosis factor-alpha (TNF-alpha) and the angiogenic factor vascular endothelial growth factor (VEGF). This study investigated the use
Central nervous system abnormalities in pediatric human immunodeficiency virus infection.: Pediatr Neurosurg. 1999 Sep;31(3):115-23. Unique Identifier : AIDSLINE MED/20170645; Gavin P; Yogev R; Department of Pediatrics, Northwestern University Medical School,; The Children's Memorial Hospital, Chicago, IL 60614, USA.; With the recent improvements in treatment of HIV, the disease has become a chronic one. The mean survival time of HIV-infected children is now 9-10 years, which is more than 4 times the mean age of such children who died in 1990. Yet, the prevalence of HIV encephalopathy has not decreased despite use of HAART. Rather,
Utility of microcalorimetry in the characterization of the browning reaction.: J Pharm Biomed Anal. 1999 Jun;20(1-2):385-8. Unique Identifier : AIDSLINE MED/20166812; Vickery RD; Maurin MB; Pharmacy R&D, DuPont Pharmaceuticals Company, Experimental; Station, Wilmington, DE 19880-0400, USA.; An isothermal microcalorimeter was utilized to characterize a model solid-state interaction. The degradation of the HIV protease inhibitor, DMP 450, in a binary mixture with hydrous lactose was followed in the presence of 5% additional water. Heat produced in the microcalorimeter sample vessel from either chemical or
HPLC-UV method for the quantitation of nevirapine in biological matrices following solid phase extraction.: J Pharm Biomed Anal. 1999 Jun;20(1-2):91-8. Unique Identifier : AIDSLINE MED/20166778; Pav JW; Rowland LS; Korpalski DJ; Department of Drug Metabolism and Pharmacokinetics, Boehringer; Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.; Nevirapine (VIRAMUNE) is a non-nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency virus type 1 (HIV-1), currently marketed for the treatment of HIV-1 infected adults. A reverse phase HPLC-UV method was optimized and validated for the determination of
LC determination of indinavir in biological matrices with electrochemical detection.: J Pharm Biomed Anal. 2000 Mar;22(2):307-14. Unique Identifier : AIDSLINE MED/20182833; Fizzano MR; Valvo L; Dupuis ML; Mennella V; Cianfriglia M; Laboratorio di Chimica del Farmaco, Istituto Superiore di; Sanita, Rome, Italy.; A high performance liquid chromatographic (HPLC) method with electrochemical detection for the quantification of Indinavir in cell culture is described. The sample pre-treatment involved a protein precipitation procedure using acetonitrile. Chromatogr
Transient eosinophilia by HIV infection.: Ann Hematol. 2000 Feb;79(2):99-101. Unique Identifier : AIDSLINE MED/20203968; Maeda Y; Miyatake J; Naiki Y; Nawata H; Sumimoto Y; Sono H; Sakaguchi M; Matsuda M; Kanamaru A; Third Department of Internal Medicine, Kinki University School of; Medicine, Osaka-Sayama, Japan. inter-3@med.kindai.ac.jp; We describe a case of early human immunodeficiency virus infection characterized by transient eosinophilia without an elevated immunoglobulin E concentration, allergic symptoms, or atopic dermatitis. Possible mechanisms of the eosinophilia are discussed.
[Tuberculosis and human immunodeficiency virus infection: clinical manifestations and performance of diagnostic procedures according to distinct forms of the localization of disease]: An Med Interna. 2000 Jan;17(1):13-8. Unique Identifier : AIDSLINE MED/20194592; Lado Lado FL; Barrio Gomez E; Carballo Arceo E; Cabarcos Ortiz de Barron A; Departamento de Medicina, Complejo Hospitalario Universitario de; Santiago de Compostela, A Coruna.; OBJECTIVES: To analyse the clinical manifestations and performance of the diagnosis methods in tuberculosis (TB) diagnosed in patients with human immunodeficiency virus infection (HIV), according to the location forms of disease (LF). MATERIAL AND METHODS: We revised 80 cases of TB diagnosed in patients with infection
[Psychological variables and adherence to antiretroviral treatment]: An Med Interna. 2000 Jan;17(1):38-41. Unique Identifier : AIDSLINE MED/20194598; Gordillo Alvarez-Valdes MV; Gonzalez-Lahoz J; Departamento de Metodos de Investigacion y Diagnostico en; Educacion, Facultad de Educacion, Universidad Complutense,; Madrid.; The aim of this study is to discuss the implications of a good adherence to antiretroviral therapy, the factors affecting adherence, and the different methods used today to evaluate it. As conclusion, the authors emphasize the convenience of an interdisciplinary collaboration between professionals in order to improve
[Improvement of severe psoriasis in a HIV(+) patient (letter)]: An Med Interna. 2000 Jan;17(1):52. Unique Identifier : AIDSLINE MED/20194606; Merino E; Torrux D; Boix V; Portilla J
[Nephrotic syndrome and acute pancreatitis related to glucantime administration (letter)]: An Med Interna. 2000 Jan;17(1):54. Unique Identifier : AIDSLINE MED/20194609; Valencia ME; Laguna F; Gonzalez Lahoz J
Similarities in the HIV-1 and ASV integrase active sites upon metal cofactor binding.: Biopolymers. 2000 Apr 5;53(4):308-15. Unique Identifier : AIDSLINE MED/20149918; Lins RD; Straatsma TP; Briggs JM; Department of Biology and Biochemistry, University of Houston,; Houston, TX 77204-5513, USA.; The HIV-1 integrase, which is essential for viral replication, catalyzes the insertion of viral DNA into the host chromosome thereby recruiting host cell machinery into making viral proteins. It represents the third main HIV enzyme target for inhibitor design, the first two being the reverse transcriptase and the prot
Interleukin-18 stimulates HIV-1 replication in a T-cell line.: Eur Cytokine Netw. 2000 Mar;11(1):47-52. Unique Identifier : AIDSLINE MED/20170960; Klein SA; Klebba C; Kauschat D; Pape M; Ozmen L; Hoelzer D; Ottmann OG; Kalina U; Universitatsklinik Frankfurt, Medizinische Klinik III,; Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.; Interleukin-18 (IL-18) is a recently identified proinflammatory cytokine. Its ability to induce interferon-g suggests a potential virustatic effect. On the other hand, it stimulates NFkB - an activator of HIV replication. Recently, stimulation of HIV-1 in monocytic cells has been demonstrated. In the present study, th
The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice.: Blood. 2000 Mar 15;95(6):2031-6. Unique Identifier : AIDSLINE MED/20173570; Sacerdote P; Manfredi B; Gaspani L; Panerai AE; Department of Pharmacology, University of Milano, Milan, Italy.; paola.sacerdote@unimi.it; Opioid peptides affect different immune functions. We present evidence that these effects could be mediated by the modulation of T(H)1/T(H)2 cytokine production. BALB/cJ mice were immunized with 50 or 100 microg of the protein antigen keyhole-limpet hemocyanin (KLH), and treated acutely or chronically with the opioid
HIV-associated dysfunction of in vitro IL-12 production depends on the nature of the stimulus and on the CD4 T-cell count of the patient [letter]: Blood. 2000 Mar 15;95(6):2185-7. Unique Identifier : AIDSLINE MED/20215990; Vanham G; Penne L; Fransen K; Kestens L; De Brabander M
Determinants of energy intake and energy expenditure in HIV and AIDS.: Nutrition. 2000 Feb;16(2):101-6. Unique Identifier : AIDSLINE MED/20161622; Sheehan LA; Macallan DC; Department of Public Health Nutrition, London School of Hygiene; and Tropical Medicine, UK.; To determine the relative importance of various factors in the causation of wasting related to human immunodeficiency virus (HIV), quantitative analysis and linear structural modeling was performed on energy metabolism data collected longitudinally and prospectively from 33 men positive for the human immunodeficiency
Continuing injecting risk behaviour: results from the Amsterdam Cohort Study of drug users.: Unique Identifier : AIDSLINE MED/20172434; Van Ameijden EJ; Langendam MW; Notenboom J; Coutinho RA; Municipal Health Service, Division of Public Health and; Environment, Amsterdam, The Netherlands.; evameijden@GGGD.amsterdam.nl; AIMS: To give a detailed description of injection-related risk behaviours, and to estimate the relative importance of these behaviours with regard to HIV transmission. DESIGN: The present study was part of the Amsterdam Cohort Study of drug users. SETTING: In Amsterdam, a city with extensive preventive measures, large
HIV and HCV infection among drug users in Japan.: Addiction. 1999 Jul;94(7):1063-9. Unique Identifier : AIDSLINE MED/20172435; Wada K; Greberman SB; Konuma K; Hirai S; National Center of Neurology and Psychiatry, National Institute; of Mental Health, Chiba, Japan.; AIMS: To assess seroprevalence of human immunodeficiency virus (HIV), hepatitis C virus, injecting drug use, unsafe sexual behaviours, self-mutilation and tattoos in patients attending a drug and alcohol treatment centre in Japan . DESIGN: Cross-sectional survey. SETTING: The work wa
Thalidomide for night sweats in patients with advanced cancer [letter]: Palliat Med. 2000 Jan;14(1):77-8. Unique Identifier : AIDSLINE MED/20182194; Calder K; Bruera E
Accelerated coronary atherosclerosis and arteriosclerosis in young human-immunodeficiency-virus-positive patients.: Coron Artery Dis. 2000 Feb;11(1):41-6. Unique Identifier : AIDSLINE MED/20180695; Tabib A; Leroux C; Mornex JF; Loire R; Laboratoire d'Anatomie et Cytologie Pathologique, INRA UR 754,; Hopital Louis Pradel, Lyon, France.; OBJECTIVE: To determine the type of lesions observed in young patients infected with human immunodeficiency virus-1 (HIV-1). DESIGN: Examination of coronary networks in corpses of 13 men and two women who had died aged 23-32 years after having been infected with HIV-1 virus, having been seropositive for 2-5 years. Cau
Enhanced in vivo human immunodeficiency virus-1 replication in the lungs of human immunodeficiency virus-infected persons with Pneumocystis carinii pneumonia.: Am J Respir Crit Care Med. 1999 Dec;160(6):2048-55. Unique Identifier : AIDSLINE MED/20056352; Koziel H; Kim S; Reardon C; Li X; Garland R; Pinkston P; Kornfeld H; Division of Pulmonary and Critical Care Medicine, Beth Israel; Deaconess Medical Center and Harvard Medical School, Boston, MA; 02215, USA. hkoziel@caregroup.harvard.edu; The relationship of serum human immunodeficiency virus-1 (HIV-1) RNA levels to HIV-1 RNA levels in other compartments, such as the lungs, is not well characterized. The purpose of this study was to determine the viral burden of HIV-1 in the lungs by comparing HIV-1 RNA in cell-free bronchoalveolar lavage fluid (BALF)
Cloning of a novel chemoattractant receptor activated by leukotriene B4 and used by human immunodeficiency virus type 1 to infect CD4-positive immune cells. A therapeutic connection to asthma?: Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 2):S56-61. Unique Identifier : AIDSLINE GENBANK/X98356; Owman C; Sabirsh A; Garzino-Demo A; Cocchi F; Division of Molecular Neurobiology, Wallenberg Neuroscience; Center, University of Lund, Lund, Sweden.; christer.owman@mphy.lu.se
P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs.: Int J Clin Pharmacol Ther. 2000 Feb;38(2):69-74. Unique Identifier : AIDSLINE MED/20168710; Fromm MF; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology,; Stuttgart, Germany.; Transport by ATP-dependent efflux pumps such as P-glycoprotein is an increasingly recognized determinant of drug disposition. P-glycoprotein does not only contribute to multidrug resistance (MDR) in tumor cells, it is also expressed in normal tissues with excretory function such as liver, kidney and intestine. Apical
Infection of intact human islets by a lentiviral vector.: Gene Ther. 1999 Sep;6(9):1545-51. Unique Identifier : AIDSLINE MED/99422055; Giannoukakis N; Mi Z; Gambotto A; Eramo A; Ricordi C; Trucco M; Robbins P; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; The transfer of genes encoding immunomodulatory proteins to islets can be used to improve islet function, block apoptosis, and inhibit rejection following transplantation. Adenoviral vectors have been shown to infect intact human islets, but the immunogenicity and transient gene expression of the current adenoviral ve
HIV-1 Vpr-chloramphenicol acetyltransferase fusion proteins: sequence requirement for virion incorporation and analysis of antiviral effect.: Gene Ther. 1999 Sep;6(9):1590-9. Unique Identifier : AIDSLINE MED/99422061; Yao XJ; Kobinger G; Dandache S; Rougeau N; Cohen E; Laboratoire de Retrovirologie Humaine, Departement de; Microbiologie et Immunologie, Faculte de Medecine, Universite; de Montreal, CP 6128, Succursale Centre-ville, Montreal,; Quebec H3C 3J7 Canada.; The human immunodeficiency virus type 1 Vpr is a virion-associated protein that is incorporated in trans into viral particles, presumably via an interaction with the p6 domain of the Gag polyprotein precursor. Recently, several studies demonstrated that Vpr fusion proteins could be used as intravirion inactivating age
Chemokines: a new classification system and their role in immunity.: Immunity. 2000 Feb;12(2):121-7. Unique Identifier : AIDSLINE GENBANK/AJ132337; Zlotnik A; Yoshie O; DNAX Research Institute, Palo Alto, California 94304, USA.; zlotnik@dnax.org
Conditioned alterations of specific blood leukocyte subsets are reconditionable.: Neuroimmunomodulation. 2000;7(2):106-14. Unique Identifier : AIDSLINE MED/20153859; Exton MS; von Horsten S; Strubel T; Donath S; Schedlowski M; Westermann J; Institute of Medical Psychology, Faculty of Medicine, University; of Essen, Germany. michael.exton@uni-essen.de; Behavioral conditioning has the ability to produce changes in immune function. However, it is unknown whether conditioned changes of immune function can be recalled on multiple occasions. To address this issue we paired a novel saccharin drinking solution with intraperitoneal cyclosporin A (CsA) injection in rats. Sac
Understanding condom use among heroin addicts in methadone maintenance using the information-motivation-behavioral skills model.: Subst Use Misuse. 2000 Mar;35(4):451-71. Unique Identifier : AIDSLINE MED/20203581; Bryan AD; Fisher JD; Fisher WA; Murray DM; University of Connecticut, Storrs, USA. angela.bryan@colorado.edu; The current study represents the application of a health behavior model to account for unsafe sexual behavior (as opposed to unsafe needle use) among heroin addicts in methadone treatment. The Information-Motivation-Behavioral Skills (IMB) model of HIV preventive behavior asserts that HIV prevention information, motiv
Substance misuse and related infectious diseases in a soup kitchen population.: Subst Use Misuse. 2000 Mar;35(4):551-83. Unique Identifier : AIDSLINE MED/20203585; Magura S; Nwakeze PC; Rosenblum A; Joseph H; Institute for Treatment and Services Resarch, National; Development and Research Institutes, Inc., New York, New York; 10048, USA. steve.magura@ndri.org; Representative samples of female (N = 119) and male (N = 100) guests were selected at two inner city soup kitchens. In the preceding month, 75% used cocaine/crack and 25% used heroin/opiates as determined by hair analysis. Relatively few guests (25%) were in substance dependency treatment. Infectious disease rates wer
[Small fiber dysfunction in peripheral neuropathies]: Rev Neurol. 1999 Mar 16-31;28(6):543-54. Unique Identifier : AIDSLINE MED/20178715; Santiago S; Espinosa ML; Perez-Conde MC; Merino M; Ferrer T; Laboratorio de SNA, Hospital La Paz, Madrid, Espana.; INTRODUCTION: Disfunction of thin myelinated and unmyelinated fibers may appear isolated or in association with large-myelinated fibers lesion. Small-fiber neuropathy includes autonomic and sensory symptoms, most prominent of them thermo-algesic deficits. DEVELOPMENT AND CONCLUSION: In some acute neuropathies, small-f
Effect of viral status on recurrence after liver resection for patients with hepatitis B virus-related hepatocellular carcinoma.: Unique Identifier : AIDSLINE MED/20164346; Kubo S; Hirohashi K; Tanaka H; Tsukamoto T; Shuto T; Yamamoto T; Ikebe T; Wakasa K; Nishiguchi S; Kinoshita H; Second Department of Surgery, Osaka City University Medical; School, Osaka, Japan.; BACKGROUND: Risk factors for recurrence after resection of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) require more precise definition. METHODS: Forty patients who underwent liver resection for HBV-related HCC were studied. Their clinical findings, laboratory data (including viral status), pathologi
DC-SIGN: a guide to some mysteries of dendritic cells [comment]: Cell. 2000 Mar 3;100(5):491-4. Unique Identifier : AIDSLINE MED/20185060; Steinman RM; Laboratory of Cellular Physiology and Immunology, The Rockefeller; University, New York, New York 10021, USA.; steinma@rockvax.rockefeller.edu
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses [see comments]: Cell. 2000 Mar 3;100(5):575-85. Unique Identifier : AIDSLINE MED/20185069; Geijtenbeek TB; Torensma R; van Vliet SJ; van Duijnhoven GC; Adema GJ; van Kooyk Y; Figdor CG; Department of Tumor Immunology, University Medical Center St.; Radboud, Nijmegen, The Netherlands.; Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is important in this first contact with DC. We discovered that instead of the common ICAM-3 receptors LFA-1 and alphaDbeta2, a novel DC-specific C-t
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells [see comments]: Cell. 2000 Mar 3;100(5):587-97. Unique Identifier : AIDSLINE MED/20185070; Geijtenbeek TB; Kwon DS; Torensma R; van Vliet SJ; van Duijnhoven GC; Middel J; Cornelissen IL; Nottet HS; KewalRamani VN; Littman DR; Figdor CG; van Kooyk Y; Department of Tumor Immunology, University Medical Center St.; Radboud, Nijmegen, The Netherlands.; Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is h
Localization of pepstatin's inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission.: Cell Immunol. 2000 Feb 1;199(2):81-8. Unique Identifier : AIDSLINE MED/20164372; Athanassakis I; Protopapadakis E; Vassiliadis S; Department of Biology, University of Crete, Heraklion, Crete,; Greece.; Antibody internalization via Fc receptors is an important cellular mechanism, possibly facilitating the entry of antigenic peptides or viral particles into cells when specific antibodies are present at the periphery. Using an experimental model of trophoblast cells, we have shown that anti-p21(ras) monoclonal antibodi
Single expression of CD45RC and RT6 in correlation with T-helper 1 and T-helper 2 cytokine patterns in the rat.: Cell Immunol. 2000 Feb 1;199(2):89-96. Unique Identifier : AIDSLINE MED/20164373; Hylkema MN; van der Deen M; Pater JM; Kampinga J; Nieuwenhuis P; Groen H; Department of Histology and Cell Biology, University of; Groningen, Groningen, The Netherlands.; Previous studies involving the function and development of peripheral T cells have proposed that, in the rat, CD4(+)CD45RC(+)RT6(-) and CD4(+)CD45RC(-)RT6(+) T-cell subsets may represent Th1 and Th2 cells, respectively. Here we tested this hypothesis directly by analyzing frequencies of IFN-gamma- and IL-4-producing c
Interferon and ribavirin combination therapy: indications and schedules.: Forum (Genova). 2000 Jan-Mar;10(1):22-8. Unique Identifier : AIDSLINE MED/20184082; Weiland O; Division of Infectious Diseases I73, Huddinge Hospital and; Karolinska Institute, Huddinge, Sweden.; Treatment outcome for patients with chronic hepatitis C virus infection has greatly improved during the last years with the development of interferon (IFN) and ribavirin combination therapy . The final decision to treat or not, however, is complex and should be based on
Hepatitis C virus: kinetics and quasispecies evolution during anti-viral therapy.: Forum (Genova). 2000 Jan-Mar;10(1):32-42. Unique Identifier : AIDSLINE MED/20184083; Zeuzem S; Medizinische Klinik II, Klinikum der Johann Wolfgang; Goethe-Universit t, Frankfurt am Main, Germany.; The balance of virus production and clearance for untreated patients with chronic hepatitis C changes into a decline of viraemia when initiating effective anti-viral treatment. During the first phase of interferon-alpha (IFN-a) therapy, the kinetics of the viral load is characterised by a rapid dose-dependent decline
What to do when standard therapy fails.: Forum (Genova). 2000 Jan-Mar;10(1):63-9. Unique Identifier : AIDSLINE MED/20184085; Buti M; Esteban R; University General Hospital Valle de Hebron, Barcelona, Spain.; An important group of patients with chronic hepatitis C do not respond to interferon (IFN) therapy. Compared with untreated patients with chronic hepatitis C, non-responders have a higher percentage of cirrhosis, are more frequently infected by genotype 1 and usually have a viral load above 2 x 106 copies/ml. Also, pa
Breastfeeding and HIV infection: a global perspective [editorial]: Hosp Med. 1999 Nov;60(11):778-9. Unique Identifier : AIDSLINE MED/20172165; Newell ML
Crystallization and preliminary X-ray analysis of luffaculin, a ribosome-inactivating protein from sponge-gourd seeds.: Acta Crystallogr D Biol Crystallogr. 2000 Feb;56 ( Pt 2):185-6. Unique Identifier : AIDSLINE MED/20133155; Ma Q; Yao G; Wu S; Li H; Li J; Dong Y; Department of Protein Engineering, Institute of Biophysics,; Chinese Academy of Science, 15 Datun Road, Beijing 100101,; People's Republic of China.; Luffaculin is a ribosome-inactivating protein. Crystals suitable for X--ray diffraction were first obtained using the hanging-drop vapour-diffusion method. X-ray studies show that the crystals belong to space group C2, with unit-cell parameters a = 89.90, b = 59.82, c = 55.18 A, beta = 120.81 degrees, and have one mol
The construction of a simulation-based system for the development of powerful and realistic models and practicals for healthcare professionals.: IEEE Trans Inf Technol Biomed. 1998 Sep;2(3):174-82. Unique Identifier : AIDSLINE MED/20184441; Diomidous M; Verginis I; Mantas J; Laboratory of Health Informatics, University of Athens, Greece.; The aim of this paper is to examine the importance of computer-based simulation by the demonstration and study of complex systems and the presentation of essential tools and applications that can help health professionals deliver good quality practicals, which is now impeded by cost and/or technical constrains. The to
The H9/M8166 tropism of various HIV-1 mutants is determined by distinct cellular factors (review).: Int J Mol Med. 2000 Mar;5(3):291-4. Unique Identifier : AIDSLINE MED/20144203; Yoshida A; Shimomoto J; Koh KB; Fujita M; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.; We have previously shown that a number of human immunodeficiency virus type 1 (HIV-1) mutants generated in vitro display a replication-defect in a cell-dependent manner. Of the mutants of this category, those of gag, vif, and env mutants do not grow at all in lymphocytic H9 (non-permissive) cells, but quite well in M8
Construction of new amplifier expression vectors for high levels of IL-2 gene expression.: Int J Mol Med. 2000 Mar;5(3):295-300. Unique Identifier : AIDSLINE MED/20144204; Tsang TC; Brailey JL; Vasanwala FH; Wu RS; Liu F; Clark PR; Meade-Tollin L; Luznick L; Stopeck AT; Akporiaye ET; Harris DT; Department of Microbiology, University of Arizona College of; Medicine, Arizona Cancer Center, Tucson, AZ 85724, USA.; The success of IL-2 gene therapy in cancer is in part dependent on the development of high level IL-2 gene expression vectors. Currently, expression vectors based on the human cytomegalovirus (
Molecular medicine: the present and the future.: Int J Mol Med. 2000 Mar;5(3):301-5. Unique Identifier : AIDSLINE MED/20144205; Fay O; Tiribelli C; Centro de Tecnologia en Salud Publica, Universidad Nacional de; Rosario, Faculdad de Ciencias Bioquimicas y Farmaceuticas,; Rosario, Argentina.; In the recent past, major achievements have been obtained in the understanding of the molecular defects at the basis of several different diseases. The field of Molecular Medicine has thus become more solid, and several reports have been published linking the basic molecular investigation to the clinical practice. I
Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART.: Clin Immunol. 2000 Mar;94(3):153-9. Unique Identifier : AIDSLINE MED/20159195; Pandolfi F; Pierdominici M; Marziali M; Livia Bernardi M; Antonelli G; Galati V; D'Offizi G; Aiuti F; Institute of Internal Medicine, Catholic University, Rome, Italy.; During HIV disease an increased in vitro apoptosis of peripheral blood mononuclear cells has been demonstrated. This can be reversed in vitro by interleukin (IL)-2. Recent trials with highly active antiretroviral therapy (HAART) and IL-2 in HIV-1-infected patients show
Functional subsets within clonally expanded CD8(+) memory T cells in elderly humans.: Clin Immunol. 2000 Mar;94(3):160-72. Unique Identifier : AIDSLINE MED/20159196; Chamberlain WD; Falta MT; Kotzin BL; Department of Medicine and Department of Immunology, University; of Colorado Health Sciences Center, Denver, Colorado 80262, USA.; With advancing age, healthy humans frequently demonstrate large clonal expansions of CD8(+) T cells in the peripheral blood, which persist for long periods of time and appear to be maintained as a population of memory cells. We studied nine large T cell clones in five elderly individuals. We noted that in most cases t
NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.: Clin Immunol. 2000 Mar;94(3):179-91. Unique Identifier : AIDSLINE MED/20159198; Cron RQ; Bartz SR; Clausell A; Bort SJ; Klebanoff SJ; Lewis DB; Division of Immunology and Transplantation Biology, Stanford; University Medical Center, Palo Alto, California 94304-5208, USA.; Cyclosporin A (CsA) is a potent inhibitor of the NFAT family of transcription factors that enhance T cell activation. The observation that human immunodeficiency virus type 1 (HIV-1)-positive transplant recipients have a reduced HIV-1 viral burden during treatment with CsA suggested that NFAT may play a direct role in
Interleukin-6 release by cultured peripheral blood mononuclear cells inversely correlates with height velocity, bone age, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 serum levels in children with perinatal HIV-1 infection.: Clin Immunol. 2000 Mar;94(3):212-8. Unique Identifier : AIDSLINE MED/20159201; de Martino M; Galli L; Chiarelli F; Verrotti A; Rossi ME; Bindi G; Galluzzi F; Salti R; Vierucci A; Department of Pediatrics, University of Florence, Florence,; I-50132, Italy. mdm@ao-meyer.toscana.it; Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children [aged 91 (median;
New antivirals - mechanism of action and resistance development.: Curr Opin Microbiol. 1998 Oct;1(5):535-46. Unique Identifier : AIDSLINE MED/99185261; Balzarini J; Naesens L; Clercq ED; Rega Institute for Medical Research Katholieke Universiteit; Leuven Minderbroedersstraat 10 B-3000 Leuven Belgium.; jan.balzarini@rega. kuleuven.ac.be.; In recent years, several novel treatment modalities emerged for a number of virus infections, including lamivudine for hepatitis B virus, abacavir , adefovir dipivoxyl and apropovir disprometil for human immunodeficiency virus, cidofovir for
Comprehensive medical care among HIV-positive incarcerated women: the Rhode Island experience.: Unique Identifier : AIDSLINE MED/20181434; Farley JL; Mitty JA; Lally MA; Burzynski JN; Tashima K; Rich JD; Cu-Uvin S; Spaulding A; Normandie L; Snead M; Flanigan TP; The Miriam Hospital and Brown University School of Medicine,; Providence, Rhode Island 02906, USA.; Our objective was to characterize the clinical presentation of human immunodeficiency virus (HIV) infection among incarcerated women in a program that provides HIV testing and primary care to all state prisoners in Rhode Island. A retrospective medical chart review on all HIV-seropositive women who were incarcerated b
Proceedings of the 2nd European Stavudine Symposium. Cannes, France, 25 April 1998.: Antivir Ther. 1998;3 Suppl 4:1-77. Unique Identifier : AIDSLINE MED/20215974
Sanctuary sites in HIV-1 infection.: Unique Identifier : AIDSLINE MED/20188471; Hoetelmans RM; The existence of sanctuary sites for human immunodeficiency virus type 1 (HIV-1) may potentially endanger the efficacy of antiretroviral therapy in the long term and may even make eradication of HIV-1 from the infected body impossible. Potential classic sanctuary sites for HIV-1 are the central nervous
Immunological effects of antiretroviral therapy.: Antivir Ther. 1998;3 Suppl 4:19-23. Unique Identifier : AIDSLINE MED/20188472; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW, Australia. d.cooper@nchecr.unsw.edu.au; The striking decline in HIV load with highly active antiretroviral combination therapy (HAART) is accompanied by substantial improvements in immune function, even in patients with more advanced disease. These include a general reduction in immune activation with increa
Hydroxyurea: mechanisms of HIV-1 inhibition.: Antivir Ther. 1998;3 Suppl 4:25-33. Unique Identifier : AIDSLINE MED/20188473; Lori F; Lisziewicz J; Research Institute for Genetic and Human Therapy (Right),; Georgetown University, Washington DC, USA.; RIGHT@gunet.georgetown.edu; Hydroxyurea inhibits cellular ribonucleotide reductase, resulting in decreased pools of dNTPs and thus inhibition of DNA synthesis. Studies in vitro have shown that hydroxyurea reduces dNTP pools in cells infected with human immunodeficiency virus type 1 (HIV-1), inhibiting HIV-1 DNA synthesis in infected quiescent an
Didanosine once daily: an overview.: Antivir Ther. 1998;3 Suppl 4:35-7. Unique Identifier : AIDSLINE MED/20188474; Youle M; Royal Free Centre for HIV Medicine, Royal Free Hospital,; Hampstead, London, UK. myoule@rfh1.demon.co.uk; The current focus on simplifying treatment regimens for patients with human immunodeficiency virus (HIV) infection has contributed to the interest in once-daily therapy. The triphosphate of didanosine (2 ,3 -dideoxyinosine or DDI) has a long intracellular half-life, which supports the use of didanosine in a once-daily
Stavudine plus a non-thymidine nucleoside reverse transcriptase inhibitor as a backbone for highly active antiretroviral therapy.: Antivir Ther. 1998;3 Suppl 4:39-43. Unique Identifier : AIDSLINE MED/20188475; Clumeck N; Department of Internal Medicine, Division of Infectious Diseases,; CHU Saint-Pierre, Brussels, Belgium. crmiclum@ulb.ac.be; Current guidelines for treatment of human immunodeficiency virus (HIV) disease favour the use of triple-drug combinations consisting of two nucleoside analogue reverse transcriptase inhibitors (NRTIs) plus a protease inhibitor to achieve maximum suppression of HIV replication. There is considerable evidence for includ
Post-exposure prevention of HIV-1 infection.: Antivir Ther. 1998;3 Suppl 4:45-7. Unique Identifier : AIDSLINE MED/20188476; Kahn JO; University of California, San Francisco, USA.; Post-exposure prevention of human immunodeficiency virus type 1 (HIV-1) infection involves a combined modality approach to subjects exposed to the HIV-1 virus through sexual or occupational contact or intravenous drug use. Identification of those at highest risk of transmission, which involves patient factors as well
Early antiretroviral therapy: rationale, protease inhibitor-sparing regimens and once daily dosing.: Antivir Ther. 1998;3 Suppl 4:49-53. Unique Identifier : AIDSLINE MED/20188477; Gatell JM; Infectious Disease Unit, Institut d'Investigacions Biomediques; Agust Pi Sunyer-Hospital Clinic, University of Barcelona, Spain.; In 1998 it seems reasonable and widely accepted that all human immunodeficiency virus type 1 (HIV-1)-infected patients willing to be treated may benefit from receiving antiretroviral therapy. Only those with undetectable plasma HIV-1 RNA, normal CD4 lymphocyte counts and lack of markers of immunological system activat
Resistance to antiretroviral drugs.: Antivir Ther. 1998;3 Suppl 4:5-7. Unique Identifier : AIDSLINE MED/20188469; Calvez V; Department of Virology, CERVI-Hopital Pitie Salpetriere,; Paris, France.; There are many questions regarding testing for viral resistance to antiretroviral drugs and interpretation of test results. The most appropriate time for testing and the compartment from which to derive virus are still uncertain. Both phenotypic and genotypic tests are used to measure drug susceptibility; however, int
Nevirapine/didanosine/lamivudine once daily in HIV-1-infected intravenous drug users.: Antivir Ther. 1998;3 Suppl 4:55-6. Unique Identifier : AIDSLINE MED/20188478; Staszewski S; Haberl A; Gute P; Nisius G; Miller V; Carlebach A; Klinikum der JW Goethe-Universitat Frankfurt, Zentrum der; Inneren Medizin, Germany. staszewski@em.uni-frankfurt.de; Human immunodeficiency virus (HIV)-infected, active intravenous drug users received once-daily therapy consisting of a combination of didanosine (2 ,3 -dideoxyinosine or DDI), lamivudine [(-)-beta-L-2 ,3 -dideoxy-3 -thiacytidine or 3TC ] and
Stavudine plus didanosine and nevirapine in antiretroviral-naive HIV-infected adults: preliminary safety and efficacy results. VIRGO Study Team.: Antivir Ther. 1998;3 Suppl 4:57-60. Unique Identifier : AIDSLINE MED/20188479; Raffi F; Reliquet V; Francois C; Garre M; Hascoet C; Allavena C; Arvieux C; Breux JP; Perre P; Rozenbaum W; Auger S; Department of Infectious Diseases, University Hospital, Nantes,; France.; The objective of this open-label trial is to evaluate the virological and immunological effects of triple therapy with stavudine (40 mg twice daily if > or = 60 kg, 30 mg twice daily if or = 60 kg, 300 mg on
dNN study: stavudine, nelfinavir and nevirapine. Preliminary safety, activity and pharmacokinetic interactions.: Antivir Ther. 1998;3 Suppl 4:61-2. Unique Identifier : AIDSLINE MED/20188480; Skowron G; Brown University School of Medicine, Roger Williams Medical; Center, Providence, Rhode Island, USA.; The dNN study evaluated the safety, efficacy and pharmacokinetic interactions of the combination of stavudine (2 ,3 -didehydro-2 ,3 -dideoxythymidine; D4T), nelfinavir and nevirapine
Ongoing open-label trials of triple therapy with stavudine and lamivudine or stavudine and didanosine plus nelfinavir.: Antivir Ther. 1998;3 Suppl 4:63-4. Unique Identifier : AIDSLINE MED/20188481; Anderson RD; Anderson Clinical Research, Inc., Pittsburgh, PA 15213, USA.; The VZN and ZEN studies are non-comparative trials assessing triple combination therapy comprising thymidine and non-thymidine analogue nucleoside reverse transcriptase inhibitors plus a protease inhibitor. Preliminary data are available for the VZN study and recruitme
Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study.: Antivir Ther. 1998;3 Suppl 4:65-7. Unique Identifier : AIDSLINE MED/20188482; Rutschmann OT; Opravil M; Iten A; Malinverni R; Vernazza PL; Bucher H; Bernasconi E; Perrin LH; Yerly S; Hirschel B; Department of Internal Medicine, University Hospital, Geneva,; Switzerland.; A total of 144 human immunodeficiency virus (HIV)-infected patients (mean CD4 cell count, 367 cells/mm3) were included in a double-blind placebo-controlled trial testing the efficacy on surrogate markers of HIV progression of the combination didanosine (2 ,3 -dideoxyinosine or DDI) plus
Stavudine-based multiple agent combinations: initial studies and ongoing comparative trials.: Antivir Ther. 1998;3 Suppl 4:69-73. Unique Identifier : AIDSLINE MED/20188483; Murphy RL; AIDS Treatment Unit, Northwestern University, Chicago, IL 60611,; USA. r-murphy@nwu.edu; Initial studies of multiple-agent antiretroviral combinations including the thymidine nucleoside analogue reverse transcriptase inhibitor (RTI) stavudine (2 ,3 -didehydro-2 ,3 -dideoxythymidine; D4T) have shown potent anti-HIV effects in both treatmen
Strategies for rescue therapy.: Antivir Ther. 1998;3 Suppl 4:75-7. Unique Identifier : AIDSLINE MED/20188484; Lange JM; National AIDS Therapy Evaluation Center, Academic Medical Center,; University of Amsterdam, The Netherlands. j.lange@amc.uva.nl; Human immunodeficiency virus (HIV) RNA load will be detectable in approximately 40% of non-naive HIV patients who are taking triple therapy after 1 year of follow-up. Treatment failure may involve factors related to the physician (poor prescribing), the patient (poor compliance due to complicated regimens or side-effe
Cellular factors: targets for the treatment of HIV infection.: Antivir Ther. 1998;3 Suppl 4:81-92. Unique Identifier : AIDSLINE MED/20188485; Lori F; Lisziewicz J; Research Institute for Genetic and Human Therapy (RIGHT),; Policlinico S Matteo, Pavia, Italy.; On 19-20 April 1998, researchers and clinical investigators from around the world gathered in Pavia, Italy , for Cellular Factors: Targets for the Treatment of HIV Infection, a comprehensive 2 day meeting designed to share the most recent findings in human immunodeficiency virus (HIV
Research Institute for Genetic and Human Therapy (RIGHT) 1998 annual meeting. Pavia, Italy, 19-20 April 1998. Abstracts.: Antivir Ther. 1998;3 Suppl 4:81-92. Unique Identifier : AIDSLINE MED/20215975
Pharmacological considerations in antiretroviral therapy.: Antivir Ther. 1998;3 Suppl 4:9-12. Unique Identifier : AIDSLINE MED/20188470; Sommadossi JP; Center for AIDS Research and Liver Center, University of Alabama; at Birmingham, USA.; Suboptimum drug exposure arising from pharmacological and pharmacokinetic factors is an important reason that combination antiretroviral therapy fails in patients with human immunodeficiency virus type 1 infection. With all three available drug classes, the major causes are drug-drug interactions and interpatient phar
Comparison of once and twice daily dosing of didanosine in combination with stavudine for the treatment of HIV-1 infection. AI 454-146 Team.: Antivir Ther. 1999;4(4):195-202. Unique Identifier : AIDSLINE MED/20188465; Monno L; Cargnel A; Soranzo ML; Chirianni A; Ferraro T; Di Stefano M; Angarano G; University of Bari, Italy.; OBJECTIVE: To compare the antiviral activity, safety and tolerability of didanosine dosed once and twice daily when administered in combination with stavudine dosed twice daily in human immunodeficiency virus type 1 (HIV-1)-infected individuals with l
Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase.: Antivir Ther. 1999;4(4):203-9. Unique Identifier : AIDSLINE MED/20188466; Quan Y; Motakis D; Buckheit R Jr; Xu ZQ; Flavin MT; Parniak MA; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute, Jewish; General Hospital, Montreal, Quebec, Canada.; We have tested both wild-type and drug-resistant mutated, recombinant human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) molecules for sensitivity to each of two non-nucleoside RT inhibitors (NNRTI), (+)-calanolide A and nevirapine
Second International Workshop on Salvage Therapy for HIV Infection. 19-21 May 1999, Toronto, Canada.: Antivir Ther. 1999;4(4):223-31. Unique Identifier : AIDSLINE MED/20188468
The maternal and child health sites' practices regarding HIV education, counseling, and testing of women of reproductive age in Chicago: barriers to universal implementation.: Unique Identifier : AIDSLINE MED/20192501; Rahimian A; Driscoll M; Taylor D; OBJECTIVES: Women of reproductive age are increasingly at risk for human immunodeficiency virus (HIV) infection. Recent advances in reducing perinatal transmission have resulted in official guidelines on universal HIV education, counseling, and voluntary testing of women of reproductive age, especially pregnant women.
Knowledge of treatment to reduce perinatal human immunodeficiency virus (HIV) transmission and likelihood of testing for HIV: results from two surveys of women of childbearing age.: Matern Child Health J. 1998 Jun;2(2):117-22. Unique Identifier : AIDSLINE MED/20192511; Ruiz JD; Molitor F; California Department of Health Services, Office of AIDS,; Sacramento 95814, USA.; OBJECTIVE: To determine whether knowledge of zidovudine treatment to reduce the risk of mother-to-child transmission of HIV increases the likelihood of HIV testing among women of childbearing age at increased risk for HIV infection. METHOD: Data from two samples were analyzed. The Young Women Survey was a population-b
Adolescent males' combined use of condoms with partners' use of female contraceptive methods.: Matern Child Health J. 1998 Dec;2(4):201-9. Unique Identifier : AIDSLINE MED/20192521; Lindberg LD; Ku L; Sonenstein FL; Urban Institute, Washington, DC 20037, USA. lduberst@ui.urban.org; OBJECTIVE: Protection from both sexually transmitted diseases and pregnancy is best obtained by the combined use of male condoms and effective female contraceptive methods. This research examines dual contraceptive method use among teenage men. METHOD: Analyzed data from the 1995 National Survey of Adolescent Males, a
The results of ingredient patch testing in contact dermatitis elicited by povidone-iodine preparations.: Unique Identifier : AIDSLINE MED/20166371; Nishioka K; Seguchi T; Yasuno H; Yamamoto T; Tominaga K; 10 cases of contact dermatitis which began during the application of povidone-iodine preparations were examined with patch tests using 2 kinds of povidone-iodine preparations and their ingredients, i.e., povidone-iodine, polyoxyethylene nonylphenyl ether and glycerin, and also the components of povidone-iodine, i.e.,
Errors in the treatment of tuberculosis in Baltimore [see comments]: Chest. 2000 Mar;117(3):734-7. Unique Identifier : AIDSLINE MED/20179554; Rao SN; Mookerjee AL; Obasanjo OO; Chaisson RE; Center for Tuberculosis Research, Johns Hopkins University,; Baltimore, MD 21287-0003, USA.; BACKGROUND: Incomplete or incorrect antibiotic therapy, especially in the initial phase of antituberculosis (anti-TB) treatment, is a major cause of acquired drug resistance and treatment failure. We determined the extent of errors in anti-TB treatment regimens by way of nonadherence to recommended treatment protocols
Differential production of IFN-gamma, analyzed at the single-cell level, by specific subsets of human NK and T cells from healthy and HIV(+) subjects.: Cytometry. 2000 Mar 1;39(3):189-94. Unique Identifier : AIDSLINE MED/20149971; Vitale M; Caruso A; Licenziati S; Rodella L; Fiorentini S; Zauli G; Castelli F; Manzoli FA; Turano A; Department of Biomedical Sciences and Biotechnologies, Division; of Human Anatomy, University of Brescia, Brescia, Italy.; vitale@med.unibs.it; BACKGROUND: Interferon gamma is a cytokine that plays a central role in immunity, and is physiologically secreted by T and NK cells under appropriate stimuli during the immune response. By means of flow cytometry, we performed a single cell analysis of interferon gamma producing NK cells and their surface phenotype in
[First HIV triple therapy with one tablet (news)]: Dtsch Med Wochenschr. 2000 Feb 25;125(8):A22. Unique Identifier : AIDSLINE MED/20188433
Variable use of therapeutic interventions for children with human immunodeficiency virus type 1 infection in Europe.: Eur J Pediatr. 2000 Mar;159(3):170-5. Unique Identifier : AIDSLINE MED/20129992; Bernardi S; Thorne C; Newell ML; Giaquinto C; Tovo PA; Rossi P; Bambino Gesu Children's Hospital, Rome, Italy.; Although a range of antiretroviral drugs are available for use in children, the appropriate paediatric regimen remains unclear. In a survey to investigate policies and practices relating to the therapeutic management of children infected by the human immunodeficiency virus (HIV), a postal questionnaire was sent to a n
Pulmonary disease possibly caused by Mycobacterium avium in an HIV-negative infant [letter]: Eur J Pediatr. 2000 Mar;159(3):225-6. Unique Identifier : AIDSLINE MED/20130005; Tuerlinckx D; Bodart E; Lacrosse M; de Bilderling G
Ocular, cerebral and systemic interrelationships of cytomegalovirus infection in a post-mortem study of AIDS patients.: Eye. 1999 Dec;13 ( Pt 6):781-5. Unique Identifier : AIDSLINE MED/20172124; Pecorella I; Ciardi A; Credendino A; Marasco A; Di Tondo U; Scaravilli F; Department of Experimental Medicine and Pathology, University of; Rome La Sapienza, Italy.; PURPOSE: Eighty-six post-mortems of AIDS patients were reviewed microscopically and the presence of cytomegalovirus ( CMV ) infection in the viscera, brain and eye was recorded. METHODS: Immunohistochemical stains and in situ h
Seroprevalence of human T cell leukaemia/lymphoma virus type I (HTLV-I) in pregnant women, patients attending venereological outpatient services and intravenous drug users from Slovenia.: Folia Biol (Praha). 1998;44(1):23-5. Unique Identifier : AIDSLINE MED/20193114; Poljak M; Bednarik J; Rednak K; Seme K; Kristancic L; Celan-Lucu B; Slovenian AIDS Reference Center, Institute of Microbiology and; Immunology, Medical Faculty, Ljubljana. poljak@ibmi.mf.uni-lj.si; To establish current seroprevalence of human T cell leukaemia/lymphoma virus type I (HTLV-I) infection in some low- and high-risk populations from Slovenia , 10,369 and 869 serum samples collected during Slovenian 1994 unlinked surveys of human immunodeficiency viruses seroprevale
Transplantation tolerance and cytokines: is suppressor cell activity mediated by Th2 cells?: Folia Biol (Praha). 1998;44(2):37-44. Unique Identifier : AIDSLINE MED/20193097; Holan V; Institute of Molecular Genetics, Academy of Sciences of the Czech; Republic, Prague. holan@img.cas.cz
[Emergence of resistant hepatitis B virus strains during long-term lamivudine therapy in human immunodeficiency virus co-infected patients]: Gastroenterol Clin Biol. 2000 Jan;24(1):125-7. Unique Identifier : AIDSLINE MED/20145830; Rey D; Fritsch S; Schmitt C; Partisani M; Kempf-Durepaire G; Nicolle M; Krantz V; De Mautort E; Stoll-Keller F; Lang JM; Centre d'Informations et de Soins de l'Immunodeficience Humaine,; Clinique Medicale A, Hopitaux Universitaires, Strasbourg.; Seven patients co-infected with hepatitis B virus (HBsAg and HBeAg carriers, quantifiable HBV DNA with the bDNA technic) and human immunodeficiency virus received a triple antiretroviral combination therapy , including lamivudine (150 mg twice a day). Hepatitis B viral e
Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response [see comments]: Gastroenterology. 2000 Mar;118(3):573-81. Unique Identifier : AIDSLINE MED/20167111; Okazaki K; Uchida K; Ohana M; Nakase H; Uose S; Inai M; Matsushima Y; Katamura K; Ohmori K; Chiba T; Department of Gastroenterology and Endoscopic Medicine, Kyoto; University Hospital, Kyoto, Japan. okak@kuhp.kyoto-u.ac.jp; BACKGROUND & AIMS: Although autoimmunity may be involved in some cases of pancreatitis, the mechanism is still unknown. To clarify this, we studied serum autoantibodies, subsets of lymphocytes, and the Th1/Th2 balance of cellular immune responses in patients with autoimmune-related pancreatitis (AIP). METHODS: Seve
Relationships between the anti-HIV V(3)-derived peptide SPC(3) and lymphocyte membrane properties involved in virus entry: SPC(3) interferes with CXCR(4).: FEMS Microbiol Lett. 2000 Feb 15;183(2):235-40. Unique Identifier : AIDSLINE MED/20141269; Barbouche R; Papandreou MJ; Miquelis R; Guieu R; Fenouillet E; CNRS, Faculte de Medecine Nord, Bd P. Dramard, 13015,; Marseille, France.; SPC(3) is a multiple antigen peptide derived from the V(3) loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD(4). Here, SPC(3) binding characteristics, its subsequent intracellular fate and the fact that it inhibite
Interleukin-4-deficient BALB/c mice develop an enhanced Th1-like response but control cardiac inflammation following Borrelia burgdorferi infection.: FEMS Microbiol Lett. 2000 Feb 15;183(2):319-25. Unique Identifier : AIDSLINE MED/20141283; Satoskar AR; Elizondo J; Monteforte GM; Stamm LM; Bluethmann H; Katavolos P; Telford SR 3rd; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, 665 Huntington. Avenue, Boston, MA 02115, USA.; Interleukin-4 has been reported to critically modulate Borrelia burgdorferi infection and Lyme arthritis in experimental murine models. To determine the in vivo role of IL-4 in controlling Lyme carditis, we compared immunological responses and the severity of cardiac inflammation in wild-type BALB/c (IL-4 +/+) and IL-
Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin.: Immunology. 1999 May;97(1):45-55. Unique Identifier : AIDSLINE MED/20196208; Ayala A; Chung CS; Xu YX; Evans TA; Redmond KM; Chaudry IH; Center for Surgical Research and Department of Surgery, Brown; University School of Medicine and Rhode Island Hospital,; Providence, RI 02903, USA.; Recent studies suggest that increased lymphocyte apoptosis (Ao) detected in peripheral blood T cells from burn patients appears to contribute to decreased lymphocyte immunoresponsiveness. However, while it is known that sepsis induces a marked depression in the splenocyte immune response (i.e. decreased interleukin-2,
Inability of interleukin-12 to modulate T-helper 0 effectors to T-helper 1 effectors: a possible distinct subset of T cells.: Immunology. 1999 May;97(1):84-91. Unique Identifier : AIDSLINE MED/20196213; Hu C; Salgame P; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; Interleukin-12 (IL-12) strongly favours the development of T-helper 1 (Th1)-type cells through its ability to induce interferon-gamma (IFN-gamma) production by natural killer cells and T cells. In the present work we analysed the effects of IL-12 on the synthesis and secretion of IFN-gamma and IL-4 by human T-cell clo
Activation, survival and apoptosis of CD45RO+ and CD45RO- T cells of human immunodeficiency virus-infected individuals: effects of interleukin-15 and comparison with interleukin-2.: Immunology. 1999 Jun;97(2):181-7. Unique Identifier : AIDSLINE MED/20196225; Naora H; Gougeon M; Unite d'Oncologie Virale, Departement SIDA et Retrovirus,; Institut Pasteur, 28, rue du Docteur Roux, 75724 Paris Cedex 15,; France.; HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 ( IL-2 ) augment depleted CD4+ T-cell numbers, such therapies have been preferentiall
Regulatory effects of Th1-type (IFN-gamma, IL-12) and Th2-type cytokines (IL-10, IL-13) on parasite-specific cellular responsiveness in Onchocerca volvulus-infected humans and exposed endemic controls.: Immunology. 1999 Jun;97(2):219-25. Unique Identifier : AIDSLINE MED/20196230; Soboslay PT; Luder CG; Riesch S; Geiger SM; Banla M; Batchassi E; Stadler A; Schulz-Key H; Institute of Tropical Medicine, University of Tubingen,; Tubingen, Germany.; The present study investigated in vitro the regulatory effects of T helper 1 (Th1)-type (interferon-gamma, IFN-gamma; interleukin-12, IL-12) and Th2-type cytokines (IL-10, IL-13) on Onchocerca volvulus-specific cellular reactivity in onchocerciasis patients, and in exposed endemic control individuals presenting no cli
Recombinant interleukin-16 selectively modulates surface receptor expression and cytokine release in macrophages and dendritic cells.: Immunology. 1999 Jun;97(2):241-8. Unique Identifier : AIDSLINE MED/20196233; Hermann E; Darcissac E; Idziorek T; Capron A; Bahr GM; Institut Pasteur de Lille, INSERM U167, Lille, France.; Interleukin-16 (IL-16), a natural ligand for the CD4 receptor, has been found to modulate T-lymphocyte function and to inhibit human immunodeficiency virus type 1 (HIV-1) replication. Antigen-presenting cells (APC), including macrophages and dendritic cells, are known to express functional surface CD4 molecules, to be
Induction of abortive and productive proliferation in resting human T lymphocytes via CD3 and CD28.: Immunology. 1999 Jun;97(2):280-6. Unique Identifier : AIDSLINE MED/20196238; Muller Y; Wolf H; Wierenga E; Jung G; Department of Hematology and Medical Oncology, University of; Munich and GSF-Research Center for Environment and Health,; Munich, Germany.; How the T-cell receptor (TCR)/CD3 complex mediates positive as well as negative signals for T-cell regulation is not fully understood. We have previously described the induction of anergy in resting human T lymphocytes after mitogenic, high-dose CD3 triggering with monoclonal antibodies. Here we report the concomitant
Human parathymic lymph node: morphological and functional significance.: Immunology. 1999 Jun;97(2):301-8. Unique Identifier : AIDSLINE MED/20196241; Tanegashima A; Yamashita A; Yamamoto H; Fukunaga T; Department of Forensic Medicine and Sciences, Mie University; School of Medicine, Edobashi, Tsu, Mie, Japan.; Parathymic lymph nodes (PTLNs) have been identified in several species, but in humans they have been noted only once before in a study 90 years ago using fetal material. We now report their occurrence in children. Human PTLNs are small but distinctive lymphatic organs located on the surface of the thymus (or sometimes
Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers.: J Biol Chem. 2000 Mar 10;275(10):7080-6. Unique Identifier : AIDSLINE MED/20167184; Rozzelle JE; Dauber DS; Todd S; Kelley R; Craik CS; Department of Pharmaceutical Chemistry, University of California,; San Francisco, California 94143, USA.; Defective variants of human immunodeficiency virus type 1 (HIV-1) protease (HIV PR) have been engineered to inhibit wild-type (wt) HIV PR activity. These variants were designed to promote the formation of heterodimers and to destabilize the formation of inactive variant homodimers of HIV-1 protease through substitutio
The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity.: J Biol Chem. 2000 Mar 3;275(9):6267-75. Unique Identifier : AIDSLINE MED/20158934; Aoki M; Schetter C; Himly M; Batista O; Chang HW; Vogt PK; Department of Molecular and Experimental Medicine, The Scripps; Research Institute, BCC239, La Jolla, California 92037, USA.; The retroviral oncogene p3k (v-p3k) of avian sarcoma virus 16 (ASV16) codes for the catalytic subunit of phosphoinositide (PI) 3-kinase, p110alpha. The v-P3k protein is oncogenic in vivo and in vitro; its cellular counterpart, c-P3k, lacks oncogenicity. Fusion of viral Gag sequences to the amino terminus of c-P3k acti
Simultaneous detection of multiplex-amplified human immunodeficiency virus type 1 RNA, hepatitis C virus RNA, and hepatitis B virus DNA using a flow cytometer microsphere-based hybridization assay.: J Clin Microbiol. 2000 Mar;38(3):1066-71. Unique Identifier : AIDSLINE GENBANK/K02083; Defoort JP; Martin M; Casano B; Prato S; Camilla C; Fert V; Immunoanalysis Department, Immunotech, a Beckman-Coulter Company,; 13276 Marseille Cedex 9, France. defoort@immunotech.fr; The feasibility of performing a multiplex assay for the detection of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNAs and hepatitis B virus (HBV) DNA is demonstrated. This assay is based (i) on the coamplification of a 142-bp fragment from the gag region of the HIV-1 genome and a 142-bp HIV
Quantitative and cost comparison of ultrasensitive human immunodeficiency virus type 1 RNA viral load assays: Bayer bDNA quantiplex versions 3.0 and 2.0 and Roche PCR Amplicor monitor version 1.5.: J Clin Microbiol. 2000 Mar;38(3):1113-20. Unique Identifier : AIDSLINE MED/20164681; Elbeik T; Charlebois E; Nassos P; Kahn J; Hecht FM; Yajko D; Ng V; Hadley K; Departments of Laboratory Medicine, University of California, San; Francisco, USA. elbeik@itsa.ucsf.edu; Quantification of human immunodeficiency virus type 1 (HIV-1) RNA as a measure of viral load has greatly improved the monitoring of therapies for infected individuals. With the significant reductions in viral load now observed in individuals treated with highly active anti-retroviral therapy (HAART), viral load assays
Single-tube balanced heminested PCR for detecting Mycobacterium tuberculosis in smear-negative samples.: J Clin Microbiol. 2000 Mar;38(3):1166-9. Unique Identifier : AIDSLINE MED/20164690; Garcia-Quintanilla A; Garcia L; Tudo G; Navarro M; Gonzalez J; Jimenez de Anta MT; Departament de Microbiologia i Parasitologia Sanitaries,; Institut d'Investigacions Biomediques Agusti Pi i Sunyer; (IDIBAPS), Facultat de Medicina, Universitat de Barcelona,; Villarroel 170, 08036 Barcelona, Spain.; In order to achieve more sensitive and specific results for the rapid diagnosis of tuberculosis, we have developed a new method, named balanced heminested PCR, which avoids the inconvenience of asymmetric amplification and has the advantages of single-tube heminested PCR. This was achieved by replacing the outer prime
Molecular characterization of Cryptosporidium isolates obtained from human immunodeficiency virus-infected individuals living in Switzerland, Kenya, and the United States.: J Clin Microbiol. 2000 Mar;38(3):1180-3. Unique Identifier : AIDSLINE MED/20164693; Morgan U; Weber R; Xiao L; Sulaiman I; Thompson RC; Ndiritu W; Lal A; Moore A; Deplazes P; World Health Organisation Collaborating Centre for the Molecular; Epidemiology of Parasitic Infections and State Agricultural; Biotechnology Centre, Murdoch University, Murdoch, WA 6150,; Australia. morgan@numbat.murdoch.edu.au; A total of 22 Cryptosporidium isolates from human immunodeficiency virus-infected patients from Kenya , Switzerland , and the United States were examined at three genetic loci: the 18S ribosomal DNA, HSP-70, an
Comparison of two commercial methods for measurement of cytomegalovirus load in blood samples after renal transplantation.: J Clin Microbiol. 2000 Mar;38(3):1209-13. Unique Identifier : AIDSLINE MED/20164700; Tong CY; Cuevas LE; Williams H; Bakran A; Department of Medical Microbiology, University of Liverpool,; Liverpool, United Kingdom. cywtong@liv.ac.uk; A cohort of 77 renal transplant recipients was prospectively studied for comparison of two commercially available cytomegalovirus ( CMV ) load assays, i.e., the COBAS AMPLICOR CMV Monitor test (Amplicor), using plasma samples,
Clonal and spontaneous origins of fluconazole resistance in Candida albicans.: J Clin Microbiol. 2000 Mar;38(3):1214-20. Unique Identifier : AIDSLINE MED/20164701; Xu J; Ramos AR; Vilgalys R; Mitchell TG; Department of Microbiology, Duke University Medical Center,; Durham, North Carolina 27710, USA. jpxu@acpub.duke.edu; The genotypes and susceptibilities to fluconazole of 78 strains of the human pathogenic yeast Candida albicans were compared. The strains comprised two sets of samples from Durham, N.C.: one from patients infected with the human immunodeficiency virus (HIV) and the other from healthy volunteers. For each strain, the M
Development of a hypersensitive detection method for human parvovirus B19 DNA.: J Clin Microbiol. 2000 Mar;38(3):1241-3. Unique Identifier : AIDSLINE MED/20164707; Sato K; Matsuda E; Kamisango K; Iwasaki H; Matsubara S; Matsunaga Y; Chugai Pharmaceutical Co. Ltd., Central Research Laboratories,; 3-41-8 Takada, Toshima-ku, Tokyo 171-8545, Japan.; satokza@chugai-pharm.co.jp; A new detection method for human parvovirus B19 DNA was established using PCR coupled with a hybridization protection assay. The amplified product was detected using acridinium ester-labeled DNA probes. By this method, a few copies of B19 DNA were detected in human serum albumin.
Use of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 to assess the performance of viral RNA quantitation tests.: Unique Identifier : AIDSLINE MED/20164709; Jagodzinski LL; Wiggins DL; McManis JL; Emery S; Overbaugh J; Robb M; Bodrug S; Michael NL; Henry M. Jackson Foundation, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.; liagodzinski@hiv.hjf.org; Optimal management of human immunodeficiency virus type 1 (HIV-1) disease requires accurate quantitation of viral RNA concentrations in plasma. Evidence for increasing geographic intermixing of HIV-1 subtypes makes equivalent quantitation of all subtypes essential. The performances of six quantitative viral RNA tests
Very low frequence of Pneumocystis carinii DNA detection by PCR in specimens from patients with lung damage [letter]: J Clin Microbiol. 2000 Mar;38(3):1307-8. Unique Identifier : AIDSLINE MED/20214132; Visconti E; Marinaci S; Zolfo M; Mencarini P; Tamburrini E; Pagliari G; Ortona E; Siracusano A
Cutaneous infections due to nontuberculous mycobacteria: histopathological review of 28 cases. Comparative study between lesions observed in immunosuppressed patients and normal hosts.: J Cutan Pathol. 2000 Mar;27(3):124-9. Unique Identifier : AIDSLINE MED/20191158; Bartralot R; Pujol RM; Garcia-Patos V; Sitjas D; Martin-Casabona N; Coll P; Alomar A; Castells A; Department of Dermatology, Hospital General Vall d'Hebron,; Barcelona, Spain. rbartralots@medynet.com; To evaluate the histopathological features observed in patients with cutaneous infections due to nontuberculous mycobacteria (NTM) and to compare the histopathological patterns observed in immunosuppressed patients and normal hosts. Twenty-eight biopsy specimens corresponding to 27 patients with cutaneous infections d
Cognitive-behavioral stress management intervention effects on anxiety, 24-hr urinary norepinephrine output, and T-cytotoxic/suppressor cells over time among symptomatic HIV-infected gay men.: J Consult Clin Psychol. 2000 Feb;68(1):31-45. Unique Identifier : AIDSLINE MED/20176173; Antoni MH; Cruess DG; Cruess S; Lutgendorf S; Kumar M; Ironson G; Klimas N; Fletcher MA; Schneiderman N; Department of Psychology, University of Miami, Coral Gables,; Florida 33124, USA. MAntoni@umiami.ir.miami.edu; The present study tested the effects of a multimodal cognitive-behavioral stress management (CBSM) intervention on anxious mood, perceived stress, 24-hr urinary catecholamine levels, and changes in T-lymphocyte subpopulations over time in symptomatic HIV+ gay men. Seventy-three men were randomized to either a group-ba
Lichen planus with involvement of all twenty nails and the oral mucous membrane.: J Dermatol. 2000 Feb;27(2):94-8. Unique Identifier : AIDSLINE MED/20186434; Takeuchi Y; Iwase N; Suzuki M; Tsuyuki S; First Department of Dermatology, Toho University School of; Medicine, Tokyo, Japan.; A 57-year-old man had had deformities of all ten fingernails for one and a half years before presentation and deformities of all ten toenails for the previous six months. The surfaces of the nails were rough, with excessive longitudinal striations. The bases of the nails were slightly hypertrophic, and the tips were a
Perianal cytomegalovirus ulcer in an HIV infected patient: case report and review of literature.: J Dermatol. 2000 Feb;27(2):99-105. Unique Identifier : AIDSLINE MED/20186435; Nico MM; Cymbalista NC; Hurtado YC; Borges LH; Department of Dermatology, Hospital das Clinicas, University of; Sao Paulo, Brazil.; We report the case of a 25-year-old man with acquired immunodeficiency syndrome, presenting with perianal ulcer and diarrhea. He had positive immunocytochemical tests for Cytomegalovirus ( CMV ) in circulating polymorphonuclear cells (PMN). The biopsy specimen was
The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis.: J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):299-308. Unique Identifier : AIDSLINE MED/20148670; Magone MT; Whitcup SM; Fukushima A; Chan CC; Silver PB; Rizzo LV; National Eye Institute, National Institutes of Health, Bethesda,; MD 20892-1858, USA.; BACKGROUND: The applied murine model of allergic conjunctivitis mimics human disease, and an immediate hypersensitivity reaction (IHR) and a late-phase cellular reaction typically develop in sensitized mice after topical challenge with the allergen. OBJECTIVE: We investigated the role of IL-4, IFN-gamma, and IL-12 in
Transcriptional regulation of HIV-1 LTR during antigen-dependent activation of primary T cells by dendritic cells.: J Leukoc Biol. 2000 Mar;67(3):432-40. Unique Identifier : AIDSLINE MED/20195243; Tsunetsugu-Yokota Y; Kato T; Yasuda S; Matsuda Z; Suzuki Y; Koyanagi Y; Yamamoto N; Akagawa K; Cho MW; Takemori T; Department of Immunology, AIDS Research Center, National; Institute of Infectious Diseases, Tokyo, Japan. yyokota@nih.go.jp; Numerous factors are known to bind human immunodeficiency virus (HIV) long terminal repeat (LTR) and activate viral transcription, but little is known as to how they function in naturally activated T cells and to what extent their binding is relevant to HIV replication in vivo. To characterize the HIV LTR-binding fact
Effect of national seminar on AIDS and anesthesia upon knowledge, attitude and practice concerning HIV among Thai anesthesia personnel.: J Med Assoc Thai. 2000 Feb;83(2):174-81. Unique Identifier : AIDSLINE MED/20176222; Charuluxananan S; Migasena R; Somboonviboon W; Chinachot T; Kunthollaxami A; Department of Anesthesiology, Faculty of Medicine, Chulalongkorn; University, Bangkok, Thailand.; In the national seminar of AIDS and Anesthesia which was a short course educational program in all aspects of HIV medicine, 195 questionnaires about knowledge, attitude and practice concerning HIV were distributed among the participants (anesthesiologists and nurse anesthetists) in 3 periods, pretest, post test (at th
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice [see comments]: J Exp Med. 2000 Mar 6;191(5):771-80. Unique Identifier : AIDSLINE MED/20171464; Kennedy MK; Glaccum M; Brown SN; Butz EA; Viney JL; Embers M; Matsuki N; Charrier K; Sedger L; Willis CR; Brasel K; Morrissey PJ; Stocking K; Schuh JC; Joyce S; Peschon JJ; Immunex Corporation, Seattle, Washington 98101, USA.; C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting. IL-15(-/-) mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8(+) T cells, and distinct subpopulations of intestinal intraepithelial lymphocytes (I
Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph.: J Exp Med. 2000 Mar 6;191(5):823-34. Unique Identifier : AIDSLINE MED/20212542; Arstila T; Arstila TP; Calbo S; Selz F; Malassis-Seris M; Vassalli P; Kourilsky P; Guy-Grand D; Institut National de la Sante et de la Recherche Medicale; (INSERM), Hopital Necker-Enfants Malades, Paris, France.; Murine gut intraepithelial (IEL) T cell receptor (TCR)-alpha/beta lymphocytes bearing CD8alpha/13 or CD8alpha/alpha coreceptors have been shown previously to express different oligoclonal TCR beta chain repertoires in the same mouse, in agreement with other evidence indicating that these two populations belong to diff
T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling.: J Exp Med. 2000 Mar 6;191(5):847-58. Unique Identifier : AIDSLINE MED/20171470; Nishikomori R; Ehrhardt RO; Strober W; Mucosal Immunity Section, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892-1890, USA.; The differentiation of CD4(+) T cells into T helper type 1 (Th1) cells is driven by interleukin (IL)-12 through the IL-12 receptor beta2 (IL-12Rbeta2) chain, whereas differentiation into Th2 cells is driven by IL-4, which downregulates IL-12Rbeta2 chain. We reexamined such differentiation using IL-12Rbeta2 chain trans
Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice.: J Exp Med. 2000 Mar 6;191(5):891-8. Unique Identifier : AIDSLINE MED/20171474; Nishimura H; Honjo T; Minato N; Department of Medical Chemistry, Graduate School of Medicine,; Kyoto University, Kyoto 606-8501, Japan.; PD-1 is an immunoglobulin superfamily member bearing an immunoreceptor tyrosine-based inhibitory motif, and disruption of the PD-1 gene results in the development of lupus-like autoimmune diseases. In this study, we examined effects of the PD-1 deficiency on the thymocyte differentiation at the clonal level using T ce
T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses.: J Exp Med. 2000 Mar 20;191(6):1069-76. Unique Identifier : AIDSLINE MED/20193706; Townsend MJ; Fallon PG; Matthews DJ; Jolin HE; McKenzie AN; Medical Research Council Laboratory of Molecular Biology,; Cambridge CB2 2QH, United Kingdom.; We have generated mice with a deficiency in T1/ST2 expression to clarify the roles of T1/ST2 in T helper cell type 2 (Th2) responses. Using immunological challenges normally characterized by a Th2-like response, we have compared the responses of T1/ST2-deficient mice with those generated by wild-type mice. Using a pri
Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity [see comments]: J Exp Med. 2000 Mar 20;191(6):937-48. Unique Identifier : AIDSLINE MED/20193693; Spada FM; Grant EP; Peters PJ; Sugita M; Melian A; Leslie DS; Lee HK; van Donselaar E; Hanson DA; Krensky AM; Majdic O; Porcelli SA; Morita CT; Brenner MB; Division of Rheumatology, Immunology, and Allergy, Department of; Medicine, Brigham and Women's Hospital at Harvard Medical School,; Boston, Massachusetts 02115, USA.; The specificity of immunoglobulins and alpha/beta T cell receptors (TCRs) provides a framework for the molecular basis of antigen recognition. Yet, evolution has preserved a separate lineage of gamma/delta antigen receptors that share characteristics of both immunoglobulins and alpha/beta TCRs but whose antigens remai
The meaning of AIDS: African American nursing students' perceptions of providing care to AIDS patients.: J Natl Black Nurses Assoc. 1999 Fall-Winter;10(2):54-64. Unique Identifier : AIDSLINE MED/20197148; Cornelius JB; Department of Nursing, Norfolk State University, Virginia, USA.; A qualitative study was conducted to explore the perceptions of African American nursing students as they provided care to acquired immunodeficiency syndrome (AIDS) patients. This research addressed the following question: What are the lived experiences of African American nursing students when they provide care to AI
Design of dimerization inhibitors of HIV-1 aspartic proteinase: a computer-based combinatorial approach.: J Comput Aided Mol Des. 2000 Feb;14(2):161-79. Unique Identifier : AIDSLINE MED/20186282; Caflisch A; Schramm HJ; Karplus M; Department of Biochemistry, University of Zurich, Switzerland.; caflisch@bioc.unizh.ch; Inhibition of dimerization to the active form of the HIV-1 aspartic proteinase (HIV-1 PR) may be a way to decrease the probability of escape mutations for this viral protein. The Multiple Copy Simultaneous Search (MCSS) methodology was used to generate functionality maps for the dimerization interface of HIV-1 PR. The
Bacillary angiomatosis affecting the oral cavity. Report of two cases and review.: J Oral Pathol Med. 2000 Feb;29(2):91-6. Unique Identifier : AIDSLINE MED/20181333; Lopez de Blanc S; Sambuelli R; Femopase F; Luna N; Gravotta M; David D; Bistoni A; Criscuolo MI; Rawson Hospital, Faculty of Dentistry, National University of; Cordoba, Argentina.; Bacillary angiomatosis (BA) is an infectious disease characterized by proliferative vascular lesions; it mainly affects HIV-positive patients. Multiple cutaneous nodular lesions together with fever, chills, malaise, anorexia, vomiting and headache are the most important clinical manifestations. It may also involve the
Divergent effect of cyclosporine on Th1/Th2 type cytokines in patients with severe, refractory rheumatoid arthritis.: Unique Identifier : AIDSLINE MED/20148228; Kim WU; Cho ML; Kim SI; Yoo WH; Lee SS; Joo YS; Min JK; Hong YS; Lee SH; Park SH; Cho CS; Kim HY; Department of Internal Medicine, Kang-Nam St. Mary's Hospital,; Catholic University of Korea, Seoul.; OBJECTIVE: To investigate the effect of cyclosporine on cytokine production, especially on T helper 1 (Th1) and T helper 2 (Th2) type cytokines, in patients with rheumatoid arthritis (RA). METHODS: A 16 week randomized, double blind, placebo controlled study of cyclosporine (2.5 to 4 mg/kg/day) was conducted in 40 pat
Immunomodulatory properties of rumalon, a glycosaminoglycan peptide complex, in patients with osteoarthritis: activation of T helper cell type 2 cytokines and antigen-specific IgG4 antigen-specific igG4 antibodies.: J Rheumatol. 2000 Feb;27(2):448-54. Unique Identifier : AIDSLINE MED/20148249; Klein R; Becker EW; Berg PA; Bernau A; Department of Internal Medicine II, University of Tubingen,; Germany.; OBJECTIVE: To assess the immunogenic properties of the glycosaminoglycan peptide complex Rumalon, an aqueous extract of bovine cartilage and bone marrow frequently used in patients with osteoarthritis (OA). METHODS: Sera from 31 patients with OA who had received several series of Rumalon injections (Group 1, n = 17: b
Cell populations involved in pigmented villonodular synovitis of the knee.: J Rheumatol. 2000 Feb;27(2):463-70. Unique Identifier : AIDSLINE MED/20148251; Oehler S; Fassbender HG; Neureiter D; Meyer-Scholten C; Kirchner T; Aigner T; Department of Pathology, University of Erlangen-Nurnberg,; Erlangen, Germany.; OBJECTIVE: Pigmented villonodular synovitis (PVNS) of the knee is a tumor-like process of uncertain nature. We analyzed the involved cell populations, iron deposition, and cell proliferation in PVNS to propose a pathogenetic concept of this still elusive disease entity. METHODS: The study was performed on a series of
Paramyxovirus F1 protein has two fusion peptides: implications for the mechanism of membrane fusion.: J Mol Biol. 2000 Mar 10;296(5):1353-65. Unique Identifier : AIDSLINE MED/20198304; Peisajovich SG; Samuel O; Shai Y; Department of Biological Chemistry, The Weizmann Institute of; Science, Rehovot, 76100, Israel.; Viral fusion proteins contain a highly hydrophobic segment, named the fusion peptide, which is thought to be responsible for the merging of the cellular and viral membranes. Paramyxoviruses are believed to contain a single fusion peptide at the N terminus of the F1 protein. However, here we identified an additional in
Immunization with a modified vaccinia virus expressing simian immunodeficiency virus (SIV) Gag-Pol primes for an anamnestic Gag-specific cytotoxic T-lymphocyte response and is associated with reduction of viremia after SIV challenge.: J Virol. 2000 Mar;74(6):2502-9. Unique Identifier : AIDSLINE MED/20148941; Seth A; Ourmanov I; Schmitz JE; Kuroda MJ; Lifton MA; Nickerson CE; Wyatt L; Carroll M; Moss B; Venzon D; Letvin NL; Hirsch VM; Division of Viral Pathogenesis, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, Massachusetts 02115, USA.; The immunogenicity and protective efficacy of a modified vaccinia virus Ankara (MVA) recombinant expressing the simian immunodeficiency virus (SIV) Gag-Pol proteins (MVA-gag-pol) was explored in rhesus monkeys expressing the major histocompatibility complex (MHC) class I allele, MamuA*01. Macaques received four sequen
Phylogenetic analyses indicate an atypical nurse-to-patient transmission of human immunodeficiency virus type 1.: J Virol. 2000 Mar;74(6):2525-32. Unique Identifier : AIDSLINE MED/20148943; Goujon CP; Schneider VM; Grofti J; Montigny J; Jeantils V; Astagneau P; Rozenbaum W; Lot F; Frocrain-Herchkovitch C; Delphin N; Le Gal F; Nicolas JC; Milinkovitch MC; Deny P; Virologie, Hopital Rothschild, Universite Paris 6, Paris,; France.; A human immunodeficiency virus (HIV)-negative patient with no risk factor experienced HIV type 1 (HIV-1) primary infection 4 weeks after being hospitalized for surgery. Among the medical staff, only two night shift nurses were identified as HIV-1 seropositive. No exposure to blood was evidenced. To test the hypothesis
Feline immunodeficiency virus Vif localizes to the nucleus.: J Virol. 2000 Mar;74(6):2533-40. Unique Identifier : AIDSLINE MED/20148944; Chatterji U; Grant CK; Elder JH; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.; Monoclonal antibodies prepared against recombinant Vif derived from the 34TF10 strain of feline immunodeficiency virus (FIV) were used to assess the expression and localization of Vif in virus-infected cells. Analyses by Western blotting and by immunoprecipitation from cells infected with FIV-34TF10 revealed the prese
Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes.: J Virol. 2000 Mar;74(6):2558-66. Unique Identifier : AIDSLINE MED/20148947; Popik W; Pitha PM; Oncology Center, The Johns Hopkins University School of Medicine,; Baltimore, Maryland 21231, USA. wpopik@jhmi.edu; Binding of human immunodeficiency virus type 1 (HIV-1) to CD4 receptors induces multiple cellular signaling pathways, including the MEK/ERK cascade. While the interaction of X4 HIV-1 with CXCR4 does not seem to activate this pathway, viruses using CCR5 for entry efficiently activate MEK/ERK kinases (W. Popik, J. E. He
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment.: J Virol. 2000 Mar;74(6):2584-93. Unique Identifier : AIDSLINE MED/20148949; Lifson JD; Rossio JL; Arnaout R; Li L; Parks TL; Schneider DK; Kiser RF; Coalter VJ; Walsh G; Imming RJ; Fisher B; Flynn BM; Bischofberger N; Piatak M Jr; Hirsch VM; Nowak MA; Wodarz D; AIDS Vaccine Program, SAIC Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center,; Frederick, Maryland 21702, USA. lifson@avpaxp1.ncifcrf.gov; To better understand the viral and host factors involved in the establishment of persistent productive infection by primate lentiviruses, we varied the time of initiation and duration of postinoculation antiretroviral treatment with tenofovir {9-[2-(R
Partial rescue of the Vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription.: J Virol. 2000 Mar;74(6):2594-602. Unique Identifier : AIDSLINE MED/20148950; Dornadula G; Yang S; Pomerantz RJ; Zhang H; The Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA.; Virion infectivity factor (Vif) is a protein encoded by human immunodeficiency virus type I (HIV-1) and is essential for viral replication. It appears that Vif functions in the virus-producing cells and affects viral assembly. Viruses with defects in the vif gene (vif-) generated from the nonpermissive cells are not
Infection of primary human monocytes by Epstein-Barr virus.: J Virol. 2000 Mar;74(6):2612-9. Unique Identifier : AIDSLINE MED/20148952; Savard M; Belanger C; Tardif M; Gourde P; Flamand L; Gosselin J; Laboratory of Viral Immunology, Centre de Recherche en; Rhumatologie et Immunologie, Centre de Recherche du CHUL,; Universite Laval, Sainte-Foy, Quebec, Canada.; Previous studies have reported that infection of monocytes by viruses such as cytomegalovirus and human immunodeficiency virus weakens host natural immunity. In the present study, we demonstrated the capability of Epstein-Barr virus (EBV) to infect and replicate in freshly isolated
Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization.: J Virol. 2000 Mar;74(6):2620-7. Unique Identifier : AIDSLINE MED/20148953; Hassett DE; Zhang J; Slifka M; Whitton JL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, California 92037, USA.; Virus infections are devastating to neonates, and the induction of active antiviral immunity in this age group is an important goal. Here, we show that a single neonatal DNA vaccination induces cellular and humoral immune responses which are maintained for a significant part of the animal s life span. We employ a sens
Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene.: J Virol. 2000 Mar;74(6):2628-35. Unique Identifier : AIDSLINE MED/20148954; zur Megede J; Chen MC; Doe B; Schaefer M; Greer CE; Selby M; Otten GR; Barnett SW; Chiron Corporation, Emeryville, California 94608, USA.; A major challenge for the next generation of human immunodeficiency virus (HIV) vaccines is the induction of potent, broad, and durable cellular immune responses. The structural protein Gag is highly conserved among the HIV type 1 (HIV-1) gene products and is believed to be an important target for the host cell-mediat
Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr.: J Virol. 2000 Mar;74(6):2636-46. Unique Identifier : AIDSLINE MED/20148955; Masuda M; Nagai Y; Oshima N; Tanaka K; Murakami H; Igarashi H; Okayama H; Department of Microbiology, Graduate School of Medicine, The; University of Tokyo, Tokyo 113-0033, Japan.; mmasuda@m.u-tokyo.ac.jp; Accessory protein Vpr of human immunodeficiency virus type 1 (HIV-1) arrests cell cycling at G(2)/M phase in human and simian cells. Recently, it has been shown that Vpr also causes cell cycle arrest in the fission yeast Schizosaccharomyces pombe, which shares the cell cycle regulatory mechanisms with higher eukaryote
Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.: J Virol. 2000 Mar;74(6):2655-62. Unique Identifier : AIDSLINE MED/20148957; Ross TM; Narayan M; Fang ZY; Minella AC; Green PL; Department of Microbiology and Immunology, Vanderbilt University; School of Medicine, Nashville, Tennessee 37232-2363, USA.; Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact
Jembrana disease virus Tat can regulate human immunodeficiency virus (HIV) long terminal repeat-directed gene expression and can substitute for HIV Tat in viral replication.: J Virol. 2000 Mar;74(6):2703-13. Unique Identifier : AIDSLINE MED/20148963; Chen H; He J; Fong S; Wilcox G; Wood C; School of Biological Sciences, University of Nebraska-Lincoln,; Lincoln, Nebraska 68588, USA.; Jembrana disease virus (JDV) is a bovine lentivirus genetically similar to bovine immunodeficiency virus; it causes an acute and sometimes fatal disease in infected animals. This virus carries a very potent Tat that can strongly activate not only its own long terminal repeat (LTR) but also the human immunodeficiency v
Comparative efficacy of recombinant modified vaccinia virus Ankara expressing simian immunodeficiency virus (SIV) Gag-Pol and/or Env in macaques challenged with pathogenic SIV.: J Virol. 2000 Mar;74(6):2740-51. Unique Identifier : AIDSLINE MED/20148967; Ourmanov I; Brown CR; Moss B; Carroll M; Wyatt L; Pletneva L; Goldstein S; Venzon D; Hirsch VM; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Rockville, Maryland 20852, USA.; Prior studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided protection from high levels of viremia and AIDS following challenge with a pathogenic strain of SIV (V. M. Hirsch et al
Functional characterization of the human immunodeficiency virus type 1 genome by genetic footprinting.: J Virol. 2000 Mar;74(6):2760-9. Unique Identifier : AIDSLINE MED/20148969; Laurent LC; Olsen MN; Crowley RA; Savilahti H; Brown PO; Howard Hughes Medical Institute, Stanford University Medical; Center, Palo Alto, California 94305, USA.; We present a detailed and quantitative analysis of the functional characteristics of the 1,000-nucleotide segment at the 5 end of the human immunodeficiency virus type 1 (HIV-1) RNA genome. This segment of the viral genome contains several important cis-acting sequences, including the TAR, polyadenylation, viral att
Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly.: J Virol. 2000 Mar;74(6):2855-66. Unique Identifier : AIDSLINE MED/20148979; Ono A; Orenstein JM; Freed EO; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.; Human immunodeficiency virus type 1 (HIV-1) particle formation and the subsequent initiation of protease-mediated maturation occur predominantly on the plasma membrane. However, the mechanism by which HIV-1 assembly is targeted specifically to the plasma membrane versus intracellular membranes is largely unknown. Prev
Identification and analysis of the K5 gene of Kaposi's sarcoma-associated herpesvirus.: J Virol. 2000 Mar;74(6):2867-75. Unique Identifier : AIDSLINE GENBANK/AF117253; Haque M; Chen J; Ueda K; Mori Y; Nakano K; Hirata Y; Kanamori S; Uchiyama Y; Inagi R; Okuno T; Yamanishi K; Department of Microbiology, Osaka University Medical School C1,; 2-2 Yamadaoka, Suita 565-0871, Japan.; Kaposi s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), belongs to the gammaherpesvirus subfamily and encodes approximately 80 open reading frames (ORFs). Among them are a few candidates for immediate-early genes (e.g., K5). We developed a monoclonal antibody (MAb), 328C7, against the K5 antige
The intact retroviral Env glycoprotein of human foamy virus is a trimer.: J Virol. 2000 Mar;74(6):2885-7. Unique Identifier : AIDSLINE MED/20148982; Wilk T; de Haas F; Wagner A; Rutten T; Fuller S; Flugel RM; Lochelt M; Structural Biology Programme, European Molecular Biology; Laboratory, Heidelberg, Germany.; Electron microscopy of negatively stained human foamy virus particles provides direct evidence for the trimeric nature of intact Env surface glycoproteins. Three-dimensional image reconstruction reveals that the Env trimer is a tapering spike 14 nm in length. The spikes were often arranged in hexagonal rings which sha
Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer.: J Virol. 2000 Mar;74(6):2888-94. Unique Identifier : AIDSLINE MED/20148983; Liu DW; Tsao YP; Kung JT; Ding YA; Sytwu HK; Xiao X; Chen SL; Department of Microbiology and Immunology, Taipei, Taiwan,; Republic of China.; In this study, we explore a potential vaccine for human papillomavirus (HPV)-induced tumors, using heat shock protein as an adjuvant, a peptide vaccine for safety, and adeno-associated virus (AAV) as a gene delivery vector. The tumor vaccine was devised by constructing a chimeric gene which contained HPV type 16 E7 cy
Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation.: J Virol. 2000 Mar;74(6):2907-12. Unique Identifier : AIDSLINE MED/20148987; Akari H; Arold S; Fukumori T; Okazaki T; Strebel K; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima, Tokushima 770-8503, Japan.; akari@basic.med.tokushima-u.ac.jp; The N-terminal alpha-helix domain of the human immunodeficiency virus type 1 (HIV-1) Nef protein plays important roles in enhancement of viral infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces. In this study, we demonstrate
The SU and TM envelope protein subunits of bovine leukemia virus are linked by disulfide bonds, both in cells and in virions.: J Virol. 2000 Mar;74(6):2930-5. Unique Identifier : AIDSLINE MED/20148991; Johnston ER; Radke K; Department of Animal Science and Graduate Group in Biochemistry; and Molecular Biology, University of California, Davis,; California 95616-8521, USA.; After the polyprotein precursor of retroviral envelope proteins is proteolytically cleaved, the surface (SU) and transmembrane (TM) subunits remain associated with each other by noncovalent interactions or by disulfide bonds. Disulfide linkages confer a relatively stable association between the SU and TM envelope prot
Functional reconstitution of thymopoiesis after human immunodeficiency virus infection.: J Virol. 2000 Mar;74(6):2943-8. Unique Identifier : AIDSLINE MED/20148993; Kitchen SG; Killian S; Giorgi JV; Zack JA; Division of Hematology-Oncology, Department of Medicine and UCLA; AIDS Institute, UCLA School of Medicine, Los Angeles, California; 90095, USA.; We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4(+) thymocyte depletion in the SCID-hu mouse to examine the immune competence of reconstituting thymocytes which appear following administration of combinatio
Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques.: J Virol. 2000 Mar;74(6):2960-5. Unique Identifier : AIDSLINE MED/20148996; Ourmanov I; Bilska M; Hirsch VM; Montefiori DC; Laboratory of Molecular Microbiology, National Institutes of; Allergy and Infectious Diseases, Rockville, Maryland 20852, USA.; Neutralizing antibodies were assessed before and after intravenous challenge with pathogenic SIVsmE660 in rhesus macaques that had been immunized with recombinant modified vaccinia virus Ankara expressing one or more simian immunodeficiency virus gene products (MVA-SIV). Animals received either MVA-gag-pol, MVA-env, M
Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA.: J Virol. 2000 Apr;74(7):3046-57. Unique Identifier : AIDSLINE MED/20173693; Cimarelli A; Sandin S; Hoglund S; Luban J; Departments of Microbiology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; Retroviral Gag polyproteins drive virion assembly by polymerizing to form a spherical shell that lines the inner membrane of nascent virions. Deletion of the nucleocapsid (NC) domain of the Gag polyprotein disrupts assembly, presumably because NC is required for polymerization. Human immunodeficiency virus type 1 NC p
Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation.: J Virol. 2000 Apr;74(7):3105-11. Unique Identifier : AIDSLINE MED/20173699; Stewart SA; Poon B; Song JY; Chen IS; Departments of Microbiology and Immunology and Medicine, UCLA; School of Medicine and Jonsson Comprehensive Cancer Center, Los; Angeles, California 90095, USA.; Human immunodeficiency virus type 1 (HIV-1) Vpr is a 96-amino-acid protein that is found associated with the HIV-1 virion. Vpr induces cell cycle arrest at the G(2)/M phase of the cell cycle, and this arrest is followed by apoptosis. We examined the mechanism of Vpr-induced apoptosis and found that HIV-1 Vpr-induced a
Complex effects of deletions in the 5' untranslated region of primate foamy virus on viral gene expression and RNA packaging.: J Virol. 2000 Apr;74(7):3141-8. Unique Identifier : AIDSLINE MED/20173704; Heinkelein M; Thurow J; Dressler M; Imrich H; Neumann-Haefelin D; McClure MO; Rethwilm A; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, Wurzburg, Germany.; Due to various advantageous features there is current interest in retroviral vectors derived from primate foamy viruses (PFVs). Two PFV cis-acting sequences have been mapped in the 5 region of the RNA (pre-)genome and in the 3 pol genomic region. In order to genetically separate PFV packaging constructs from vector
Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replication.: Unique Identifier : AIDSLINE MED/20173710 P; Camerini D; Su HP
Pathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu mice.: J Virol. 2000 Apr;74(7):3205-16. Unique Identifier : AIDSLINE MED/20173711; Scoggins RM; Taylor JR Jr; Patrie J; van't Wout AB; Schuitemaker H; Camerini D; Department of Microbiology and Myles H. Thaler Center for AIDS; and Human Retrovirus Research, Division of Biostatistics and; Epidemiology, University of Virginia, Charlottesville, Virginia; 22908, USA.; We studied the replication and cytopathicity in SCID-hu mice of R5 human immunodeficiency virus type 1 (HIV-1) biological clones from early and late stages of infection of three patients who never developed MT-2 cell syncytium-inducing (SI; R5X4 or X4) viruses. Several of the late-stage non-MT-2 cell syncytium-inducin
Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts.: J Virol. 2000 Apr;74(7):3264-72. Unique Identifier : AIDSLINE MED/20173717; Nguyen DH; Hildreth JE; Department of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205, USA.; A number of recent studies have demonstrated the significance of detergent-insoluble, glycolipid-enriched membrane domains or lipid rafts, especially in regard to activation and signaling in T lymphocytes. These domains can be viewed as floating rafts composed of sphingolipids and cholesterol which sequester glycosylp
The T-cell receptor zeta chain contains two homologous domains with which simian immunodeficiency virus Nef interacts and mediates down-modulation.: J Virol. 2000 Apr;74(7):3273-83. Unique Identifier : AIDSLINE MED/20173718; Schaefer TM; Bell I; Fallert BA; Reinhart TA; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pittsburgh,; Pennsylvania 15261, USA.; We have recently demonstrated that simian immunodeficiency virus (SIV) Nef binds to the zeta chain of the T-cell receptor (TCR), leading to its down-modulation from T-cell surfaces (I. Bell, C. Ashman, J. Maughan, E. Hooker, F. Cook, and T. A. Reinhart, J. Gen. Virol. 79:2717-2727, 1998). Using a panel of human as wel
The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577.: J Virol. 2000 Apr;74(7):3388-98. Unique Identifier : AIDSLINE GENBANK/AF210726; Alexander L; Denekamp L; Knapp A; Auerbach MR; Damania B; Desrosiers RC; New England Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9102, USA.; The primary sequence of the long unique region L-DNA (L for low GC) of rhesus monkey rhadinovirus (RRV) isolate 26-95 was determined. The L-DNA consists of 130,733 bp that contain 84 open reading frames (ORFs). The overall organization of the RRV26-95 genome was found to be very similar to that of human Kaposi sarcoma
Assembly and processing of human immunodeficiency virus Gag mutants containing a partial replacement of the matrix domain by the viral protease domain.: J Virol. 2000 Apr;74(7):3418-22. Unique Identifier : AIDSLINE MED/20173735; Wang CT; Chou YC; Chiang CC; Institute of Clinical Medicine, National Yang-Ming University; School of Medicine, and Department of Medical Research and; Education, Taipei Veterans General Hospital, Taipei 112, Taiwan,; Republic of China. ctwang@vghtpe.gov.tw; We constructed human immunodeficiency virus (HIV) mutants by replacing the matrix domain with sequences encoding the viral protease or p6* and protease. The chimeras retaining matrix myristylation and processing signals underwent efficient autoprocessing with severely defective particle budding. The budding defects of
Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants.: J Virol. 2000 Apr;74(7):3427-9. Unique Identifier : AIDSLINE MED/20173737; Kim JJ; Yang JS; VanCott TC; Lee DJ; Manson KH; Wyand MS; Boyer JD; Ugen KE; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; An important limitation of DNA immunization in nonhuman primates is the difficulty in generating high levels of antigen-specific antibody responses; strategies to enhance the level of immune responses to DNA immunization may be important in the further development of this vaccine strategy for humans. We approached thi
[CD56-positive adult T-cell leukemia manifested by abnormal lung shadows]: Rinsho Ketsueki. 2000 Jan;41(1):32-6. Unique Identifier : AIDSLINE MED/20159719; Koike M; Sekikawa I; Yoshioka Y; Iida N; Hirose S; Oshimi K; Department of Internal Medicine, Juntendo Izunagaoka Hospital.; A 54-year-old woman was admitted to Juntendo Izunagaoka Hospital on Aug. 29, 1998, after experiencing cough and fever for 19 days. Chest X-ray films disclosed infiltrates in the left lung field. The abnormal lung shadows progressed despite antibiotic therapy, and enlargement of superficial lymph nodes and hepatospleno
[Effect of serotype specific glycopeptidolipid (GPL) isolated from Mycobacterium avium complex (MAC) on phagocytosis and phagosome-lysosome fusion of human peripheral blood monocytes]: Kekkaku. 2000 Jan;75(1):9-18. Unique Identifier : AIDSLINE MED/20154403; Takegaki Y; Department of Bacteriology and Urology, Osaka City University; Medical School, Japan.; Mycobacterium avium complex (MAC) is a typical intracellular parasite similar to M. tuberculosis and is one of the most important pathogens that coinfects AIDS patients. Attention has been focused on M. avium infection causing immunosuppression of hosts. Specific serotype-subspecies such as 1, -4 or -8 serotypes can b
Advances in the treatment of graft-versus-host disease.: Leukemia. 2000 Mar;14(3):509-10. Unique Identifier : AIDSLINE MED/20183071; Vogelsang GB; Johns Hopkins University, Baltimore, MD 21287, USA.; Graft-versus-host disease (GVHD) is a complicated disease whose treatment requires an equally multifaceted approach. Recipient conditioning, donor T cell activation, and end stage effectors all may be potential targets for treatment. Many drugs used in the past are returning to the forefront for investigation. Some of
HTLV Molecular Biology and Pathogenesis. Warrenton, Virginia, USA. March 17-19, 2000. Abstracts.: Leukemia. 2000 Mar;14(3):527-62. Unique Identifier : AIDSLINE MED/20215960
The HIV-1 reverse transcription (RT) process as target for RT inhibitors.: Med Res Rev. 2000 Mar;20(2):129-54. Unique Identifier : AIDSLINE MED/20190086; Jonckheere H; Anne J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.; Since the Human Immunodeficiency Virus Type 1 (HIV-1) was identified as the etiologic agent of the Acquired Immune Deficiency Syndrome (AIDS), the HIV-1 reverse transcriptase (RT) has been the subject of intensive study. The reverse transcription entails the transition of the single-stranded viral RNA into double-stra
Actin mediates Encephalitozoon intestinalis entry into the human enterocyte-like cell line, Caco-2.: Microb Pathog. 2000 Feb;28(2):51-8. Unique Identifier : AIDSLINE MED/20112987; Foucault C; Drancourt M; Unite des Rickettsies, Faculte de la Medecine CNRS UPRESA 6020,; Marseille, France.; Microsporidia are spore-forming obligate intracellular eucaryotes that parasitize eukaryotic cells. Encephalitozoon intestinalis (formerly Septata intestinalis) is a microsporidian species of emerging medical importance, responsible for chronic diarrhoea in immunocompetent patients and enteritis and systemic infection
[Mycobacterium avium infection presenting as a mass in the right lung]: Med Klin. 2000 Feb 15;95(2):93-5. Unique Identifier : AIDSLINE MED/20178474; Schleiermacher D; Rockstroh JK; Wilhelm K; Spengler U; Medizinische Klinik, Universitat Bonn. schleier@pasteur.fr; BACKGROUND: The diagnostic procedure of pulmonary masses in patients with AIDS is presented. CASE REPORT: A 39-year-old patient with AIDS was admitted to hospital because of a non-productive cough and radiologic evidence of mediastinal and right hilar masses suggestive of lymphoma associated with pneumonia of the righ
p21-activated kinase 1 plays a critical role in cellular activation by Nef.: Mol Cell Biol. 2000 Apr;20(7):2619-27. Unique Identifier : AIDSLINE MED/20180088; Fackler OT; Lu X; Frost JA; Geyer M; Jiang B; Luo W; Abo A; Alberts AS; Peterlin BM; Howard Hughes Medical Institute, Departments of Medicine,; Microbiology, and Immunology, San Francisco, California; 94143-0703, USA.; The activation of Nef-associated kinase (NAK) by Nef from human and simian immunodeficiency viruses is critical for efficient viral replication and pathogenesis. This induction occurs via the guanine nucleotide exchange factor Vav and the small GTPases Rac1 and Cdc42. In this study, we identified NAK as p21-activated
Kaposi's sarcoma.: N Engl J Med. 2000 Apr 6;342(14):1027-38. Unique Identifier : AIDSLINE MED/20193156; Antman K; Chang Y; Department of Medicine, Columbia University College of Physicians; and Surgeons, New York, NY 10032, USA.
Cryptococcal meningitis in the immunocompromised host: intracranial hypertension and other complications.: Mycopathologia. 1999;146(1):1-8. Unique Identifier : AIDSLINE MED/20186292; Stevens DA; Denning DW; Shatsky S; Armstrong RW; Adler JD; Lewis BH; Department of Medicine, Santa Clara Valley Medical Center, San; Jose, CA, USA. stevens@leland.stanford.edu; Cryptococcosis as a complication of the immunocompromised host has dramatically increased in frequency since the start of the AIDS epidemic. This trend has heightened awareness of the complications of cryptococcal meningitis; of these, intracranial hypertension is common, severe, and life-threatening, as exemplified b
Japanese officials found guilty in HIV blood case [news]: Nature. 2000 Mar 2;404(6773):10-1. Unique Identifier : AIDSLINE MED/20179163
Analysis of polio vaccine could end dispute over how AIDS originated [news]: Nature. 2000 Mar 2;404(6773):9. Unique Identifier : AIDSLINE MED/20179162; Butler D
Panel will seek 'appropriate' AIDS goals for South Africa [news]: Nature. 2000 Mar 9;404(6774):115. Unique Identifier : AIDSLINE MED/20186733; Cherry M
Preventing neonatal HIV infection [editorial]: N Z Med J. 2000 Jan 28;113(1102):1-2. Unique Identifier : AIDSLINE MED/20202977; Chambers ST; Teele D; Aickin DR; Grimwood K
Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein.: Oncogene. 2000 Mar 9;19(11):1448-56. Unique Identifier : AIDSLINE MED/20190098; Harhaj EW; Good L; Xiao G; Uhlik M; Cvijic ME; Rivera-Walsh I; Sun SC; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, 500 University Drive, Hershey,; Pennsylvania, PA 17033, USA.; NF-kappa B plays a pivotal role in normal T-cell activation and may also mediate human T-cell leukemia virus (HTLV)-induced T-cell transformation. Activation of NF-kappa B by both T-cell costimulatory signals and the HTLV Tax protein involves stimulation of I kappa B kinase (IKK). As a genetic approach to dissect the
Immune regulation of protection and pathogenesis in Plasmodium falciparum malaria.: Parassitologia. 1999 Sep;41(1-3):131-8. Unique Identifier : AIDSLINE MED/20162953; Troye-Blomberg M; Perlmann P; Mincheva Nilsson L; Perlmann H; Department of Immunology, Arrhenius Laboratories F5, Stockholm; University, Sweden. marita@imm2.su.se; The immune mechanisms whereby malaria parasites are eliminated by the human host or how they may avoid the immune response are poorly understood. Individuals living in malaria-endemic areas gradually acquire immunity. It is well established that this immunity involves both cell-mediated and humoral mechanisms and that
Delaying antimalarial drug resistance with combination chemotherapy.: Unique Identifier : AIDSLINE MED/20162980; White NJ; Faculty of Tropical Medicine, Mahidol University, Bangkok,; Thailand. fnnjw@gold.diamond.mahidol.ac.th; Resistance to antimalarial drugs arises when spontaneously occurring mutants with gene mutations or amplifications which confer reduced drug susceptibility are selected, and are then transmitted. Simultaneous use of two or more antimalarials with different modes of action and which therefore do not share the same resi
Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials.: Unique Identifier : AIDSLINE MED/20163000; Nardin E; Zavala F; Nussenzweig V; Nussenzweig RS; Department of Medical and Molecular Parasitology, New York; University School of Medicine, NY 10010, USA.; In order to provide a rational basis for the development of a pre-erythrocytic malaria vaccine we have aimed at: (a) elucidating the mechanisms of protection, and (b) identifying vaccine formulations that best elicit protection in experimental animals and humans. Based on earlier successful immunization of experimenta
Visceral leishmaniasis masquerading as tuberculosis in a patient with AIDS.: Postgrad Med J. 1999 Dec;75(890):732-4. Unique Identifier : AIDSLINE MED/20161086; Yaduvanshi A; Jain M; Jain SK; Jain S; Arora S; Departments of Medicine and Pathology, Maulana Azad Medical; College and Associated Lok Nayak Hospital, New Delhi 110 002,; India.; We report a case of visceral leishmaniasis presenting as significant lymphadenopathy in a patient with acquired immune deficiency syndrome. The lymphadenopathy was initially suspected to be tubercular in nature on pathological examination. This report highlights the increasing incidence of acquired immune deficiency s
[Disseminated Penicillium marneffei infection suggesting visceral leishmaniasis in an HIV infected patient]: Presse Med. 2000 Feb 26;29(7):363-4. Unique Identifier : AIDSLINE MED/20188436; Rosenthal E; Marty P; Ferrero C; Le Fichoux Y; Cassuto JP; Service d'Hematologie clinique, Hopital Archet 2, Nice.; GERCBT.CASSUTO@wanadoo.fr; BACKGROUND: Penicilliosis is a fungal infection caused by Penicillium marneffei. In Southeast Asia, this infection is common in HIV-infected patients but few cases have been reported in Europe. CASE REPORT: The patient lived in southern France . He had HIV infection and was immunoco
Pearls and pitfalls in the diagnosis of ureterolithiasis with unenhanced helical CT.: Radiographics. 2000 Mar-Apr;20(2):439-47; quiz 527-8, 532. Unique Identifier : AIDSLINE MED/20181989; Dalrymple NC; Casford B; Raiken DP; Elsass KD; Pagan RA; Department of Diagnostic Radiology, Wilford Hall Medical Center,; Lackland Air Force Base, TX 78236-5302, USA.; ncdalrymple@earthlink.net; Several signs to assist interpretation of unenhanced helical computed tomographic (CT) scans obtained for suspected ureterolithiasis have been described. Because signs such as perinephric stranding are not always readily apparent, a methodical approach to interpretation of CT studies is important in determining the pr
Joint analysis of HIV and AIDS surveillance data in back-calculation.: Stat Med. 2000 Feb 15;19(3):297-311. Unique Identifier : AIDSLINE MED/20115935; Bellocco R; Marschner IC; Department of Biostatistics, Harvard School of Public Health, 665; Huntington Avenue, Boston, MA 02115, USA. rino@mep.ki.se; AIDS surveillance data are the main source of information to perform back-calculation of HIV incidence. We propose a method to incorporate additional information gained by linkage with an HIV surveillance system, containing data on the time of first positive HIV test. In this paper we generalize an earlier method that
Multiple imputation for simple estimation of the hazard function based on interval censored data.: Stat Med. 2000 Feb 15;19(3):405-19. Unique Identifier : AIDSLINE MED/20115943; Bebchuk JD; Betensky RA; Department of Biostatistics, Harvard School of Public Health, 655; Huntington Avenue, Boston, Massachusetts 02115, USA.; A data augmentation algorithm is presented for estimating the hazard function and pointwise variability intervals based on interval censored data. The algorithm extends that proposed by Tanner and Wong for grouped right censored data to interval censored data. It applies multiple imputation and local likelihood method
[Infective diarrhea]: Rev Med Suisse Romande. 2000 Jan;120(1):25-9. Unique Identifier : AIDSLINE MED/20169965; Zwahlen A; Service de medecine interne, Hopital de zone St-Loup Orbe.
[HIV: epidemiology and treatment --2000]: Rev Med Suisse Romande. 2000 Jan;120(1):39-41. Unique Identifier : AIDSLINE MED/20169967; Telenti A; Hirschel B; Centre hospitalier universitaire vaudois, Lausanne.; amalio.telenti@chuv.hospvd.ch
Beta 2-microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta 2-microglobulin /- mice.: Scand J Immunol. 2000 Mar;51(3):219-23. Unique Identifier : AIDSLINE MED/20200786; Freland S; Ljunggren HG; Microbiology and Tumour Biology Center, Karolinska Institutet,; SE-171 77 Stockholm, Sweden.; Beta 2-microglobulin (beta 2m) -/- mice have often been used as a model to investigate host resistance to grafted tissues in the absence of CD8+ T cells. However, the realization that beta 2m /- mice have a small pool of CD8+ T cells imply that these cells may take part in immune responses in vivo. To directly address
Schistosoma mansoni in mice: the pattern of primary cercarial exposure determines whether a secondary infection post-chemotherapy elicits a T helper 1- or a T helper 2-associated immune response.: Scand J Immunol. 2000 Mar;51(3):237-43. Unique Identifier : AIDSLINE MED/20200789; Farah IO; Johansson M; Lovgren-Bengtson K; Hau J; Division of Comparative Medicine, Department of Physiology,; Biomedical Centre, Uppsala University, Sweden.; Reinfection with Schistosoma mansoni following chemotherapy often results in an ameliorated granulomatous reaction and hence a mild disease. This study examined some of the immunological mechanisms that could be associated with this residual protection. BALB/c mice were infected with either a single dose (group A) of
Diminished expression of CD59 on activated CD8+ T cells undergoing apoptosis in systemic lupus erythematosus and Sjogren's syndrome.: Scand J Immunol. 2000 Mar;51(3):293-9. Unique Identifier : AIDSLINE MED/20200796; Tsunoda S; Kawano M; Koni I; Kasahara Y; Yachie A; Miyawaki T; Seki H; Second Department of Internal Medicine; Department of Pediatrics,; School of Medicine, Kanazawa University, Kanazawa, Japan.; The present study was undertaken to examine the phenotype of T cells undergoing in vitro apoptosis in patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and primary Sjogren s syndrome (SS). Compared with normal controls, we found diminished expression of CD59 antigen (one of the cell-surface
Elevated CD40 ligand expressing blood T-cell levels in multiple sclerosis are reversed by interferon-beta treatment.: Unique Identifier : AIDSLINE MED/20200799; Teleshova N; Bao W; Kivisakk P; Ozenci V; Mustafa M; Link H; Division of Neurology, Neuroimmunology Unit, Karolinska; Institutet, Huddinge University Hospital, Stockholm, Sweden.; Myelin protein reactive CD4+ T cells are considered to be involved in the proposed immunopathogenesis of multiple sclerosis (MS). One particularly important molecule for T-cell activation is the CD40L (gp39) that is expressed on the surface of T cells. This study focuses on the CD40 and the CD40L expression on mononuc
Pyomyositis in the acquired immunodeficiency syndrome.: South Med J. 2000 Mar;93(3):330-4. Unique Identifier : AIDSLINE MED/20190855; Al-Tawfiq JA; Sarosi GA; Cushing HE; Department of Medicine, Indiana University School of Medicine,; Indianapolis, USA.; Pyomyositis, a purulent infection of skeletal muscle, is usually caused by Staphylococcus aureus. Many cases of pyomyositis in human immunodeficiency virus (HIV) seronegative patients have been reported in North America and have been reviewed extensively. Moreover, pyomyositis has been reported in association with HIV
Reactivation of Chagas disease manifested by skin lesions in a patient with AIDS.: Trans R Soc Trop Med Hyg. 1999 Nov-Dec;93(6):631-2. Unique Identifier : AIDSLINE MED/20182215; Sartori AM; Sotto MN; Braz LM; Oliveira Junior O da C; Patzina RA; Barone AA; Shikanai-Yasuda MA; Clinic of Infectious and Parasitic Diseases, University of Sao; Paulo School of Medicine, Brazil. amsartori@sti.com.br
Efficacy and safety of lamivudine in renal transplant patients with chronic hepatitis B.: Transplant Proc. 2000 Mar;32(2):384-5. Unique Identifier : AIDSLINE MED/20182056; Antoine C; Landau A; Menoyo V; Duong JP; Duboust A; Glotz D; Sce de Nephrologie, Inserm U 430, Paris, France.
Cytokine expression in peripheral CD57(+) T cells from tolerant renal allograft recipients.: Transplant Proc. 2000 Mar;32(2):386-7. Unique Identifier : AIDSLINE MED/20182057; Hebib C; Rouleau M; Hirsch F; Durrbach A; Legendre C; Senik A; Charpentier B; Laboratoire d'Immunologie Cellulaire et de Transplantation,; Villejuif, France.
[Role of cryptosporidia and microsporidia in diarrhea in immunocompromised patients]: Tunis Med. 1999 Dec;77(12):638-43. Unique Identifier : AIDSLINE MED/20194348; Belhadj S; Kallel K; Boussen N; Ghobantini A; Bejaoui M; Ben Salem N; Zribi A; Ben Chaabane T; Chaker E; Laboratoire de Parasitologie-Mycologie, Hopital la Rabta.; Cryptosporidium and Microsporidian play an important part in the diarrhoeic pathology of the immunocompromised patients. The study of 35 cases of cryptosporidiosis and 4 cases of intestinal microsporidiosis diagnosed in the parasitology laboratory of Rabta hospital of
Mammalian microsporidiosis.: Vet Pathol. 2000 Mar;37(2):113-28. Unique Identifier : AIDSLINE MED/20177122; Wasson K; Peper RL; Office of Laboratory Animal Resources, University of Illinois,; Urbana 61801, USA.; The phylum Microspora contains a diverse group of single-celled, obligate intracellular protozoa sharing a unique organelle, the polar filament, and parasitizing a wide variety of invertebrate and vertebrate animals, including insects, fish, birds, and mammals. Encephalitozoon cuniculi is the classic microsporidial pa
[Helicobacter pylori infections and autoimmunity: the interplay in the pathogenesis of gastritis]: Verh Dtsch Ges Pathol. 1999;83:56-61. Unique Identifier : AIDSLINE MED/20178543; Kirchner T; Faller G; Pathologisch-Anatomisches Institut, Universitat; Erlangen-Nurnberg.; Recent studies suggest a significant association of Helicobacter pylori (H.p.) gastritis and antigastric autoimmunity. Sera of H.p. infected patients exhibit antigastric autoantibodies with high prevalence (over 50 percent of the cases) and with antiluminal and/or anticanalicular binding patterns on gastric mucosa. Mo
Epstein-Barr virus dacryoadenitis.: Am J Ophthalmol. 2000 Mar;129(3):372-5. Unique Identifier : AIDSLINE MED/20170757; Rhem MN; Wilhelmus KR; Jones DB; Cullen Eye Institute, Department of Ophthalmology, Baylor College; of Medicine, Houston, Texas, USA.; PURPOSE:To describe the clinical features of lacrimal gland inflammation associated with Epstein-Barr virus infection. METHODS:The clinical records, laboratory data, and radiographs of patients who had inflammation of one or both lacrimal glands that had begun less than 4 weeks previously were reviewed.RESULTS:Sixteen
Corneal endothelial deposits in children positive for human immunodeficiency virus receiving rifabutin prophylaxis for Mycobacterium avium complex bacteremia [letter; comment]: Unique Identifier : AIDSLINE MED/20212575 P; Arevalo JF; Freeman WR
Study of the Th1/Th2 balance, including IL-10 production, in cultures of peripheral blood mononuclear cells from birch-pollen-allergic patients.: Allergy. 2000 Feb;55(2):171-5. Unique Identifier : AIDSLINE MED/20189266; Moverare R; Elfman L; St~alenheim G; Bjornsson E; Department of Allergy/Asthma, Pharmacia & Upjohn Diagnostics AB,; Uppsala, Sweden.; BACKGROUND: Excessive production of interleukin (IL)-4, IL-5, IL-10, and IL-13 is thought to be important in the development of allergy and asthma. The objective of this investigation was to study Th1/Th2-like cytokine profiles in vitro in seven patients allergic to birch pollen and six nonallergic controls during the
[The characteristics of the use and the levels of diffusion of nonconventional medicine]: Ann Ist Super Sanita. 1999;35(4):489-97. Unique Identifier : AIDSLINE MED/20185995; Menniti-Ippolito F; De Mei B; Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Roma.; The national trends of the utilisation of non conventional therapies suggest that an increasing number of patients employ remedies that are outside the mainstream of what has been defined as conventional western medicine. The extent to which these practices have clinical efficacy according to biomedical criteria is a
[Early treatment of sexual exposure to human immunodeficiency virus]: Ann Dermatol Venereol. 2000 Jan;127(1):122-4. Unique Identifier : AIDSLINE MED/20183301; Derancourt C; Drobacheff C; Verraes S; Beguinot I; Bernard P; Service de Dermatologie, Hopital Robert Debre, avenue du; General-Koenig, 51092 Reims Cedex.
[Superficial cheilitis and angular cheilitis]: Ann Dermatol Venereol. 2000 Jan;127(1):88-92. Unique Identifier : AIDSLINE MED/20183295; Kuffer R; Husson C; Service de Dermatologie (Pr J.-P. Escande), Hopital Tarnier, 89,; rue d'Assas, 75006 Paris.
Successful treatment of Rhodococcus equi pulmonary infection in a renal transplant recipient.: Ann R Coll Surg Engl. 2000 Mar;82(2):107-8. Unique Identifier : AIDSLINE MED/20207831; Marsh HP; Bowler IC; Watson CJ; Department of Urology, Churchill Hospital, Oxford, UK.; The rhodococcus is a mycobacterium-like organism which is normally a pathogen in foals. It usually spreads by direct contact or by aerosol from horse faeces and causes pyogranulomatous pulmonary infections. Occasionally, it acts opportunistically to infect immuno-compromised human hosts, most commonly those with the a
Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells.: Antimicrob Agents Chemother. 2000 Mar;44(3):496-503. Unique Identifier : AIDSLINE MED/20145360; Pan-Zhou XR; Cui L; Zhou XJ; Sommadossi JP; Darley-Usmar VM; Department of Clinical Pharmacology, Center for AIDS Research,; University of Alabama at Birmingham, Birmingham, Alabama; 35294-0019, USA.; Numerous studies have reported effects of antiviral nucleoside analogs on mitochondrial function, but they have not correlated well with the observed toxic side effects. By comparing the effects of the five Food and Drug Administration-approved anti-human immunodeficiency virus nucleoside analogs, zidovudine (3 -azido
In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir.: Antimicrob Agents Chemother. 2000 Mar;44(3):551-60. Unique Identifier : AIDSLINE MED/20145368; Colledge D; Civitico G; Locarnini S; Shaw T; Victorian Infectious Diseases Reference Laboratory, North; Melbourne, Victoria, 3051, Australia.; Penciclovir {9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine [PCV]}, lamivudine ([-]-beta-L-2 ,3 -dideoxy-3 -thiacytidine [ 3TC ]), and adefovir (9-[2-phosphonylmethoxyethyl]-adenine [PMEA]) are potent inhibitors of hepatitis B virus (HBV) replicati
A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V.: Antimicrob Agents Chemother. 2000 Mar;44(3):568-73. Unique Identifier : AIDSLINE MED/20145370; Hertogs K; Bloor S; De Vroey V; van Den Eynde C; Dehertogh P; van Cauwenberge A; Sturmer M; Alcorn T; Wegner S; van Houtte M; Miller V; Larder BA; Virco NV, Mechelen, Belgium. kurt.hertogs@virco.be; We describe a new human immunodeficiency virus type 1 (HIV-1) mutational pattern associated with phenotypic resistance to lamivudine ( 3TC ) in the absence of the characteristic replacement of methionine by valine at position 184 (M184V) of reverse tran
A dose ranging study of the pharmacokinetics, safety, and preliminary efficacy of lamivudine in children and adolescents with chronic hepatitis B.: Antimicrob Agents Chemother. 2000 Mar;44(3):590-7. Unique Identifier : AIDSLINE MED/20145374; Sokal EM; Roberts EA; Mieli-Vergani G; McPhillips P; Johnson M; Barber J; Dallow N; Boxall E; Kelly D; Universite Catholique de Louvain, Brussels, Belgium.; sokal@pedi.ucl.ac.be; Fifty-three patients with chronic hepatitis B and active viral replication were studied for 4 weeks while on treatment and for 12 weeks after treatment with the oral nucleoside analogue lamivudine. Children aged 2 to 12 years were randomized to receive twice-daily doses of 0.35, 1.5, or 4 mg of lamivudine solution per
Indinavir pharmacokinetics and parmacodynamics in children with human immunodeficiency virus infection.: Antimicrob Agents Chemother. 2000 Mar;44(3):752-5. Unique Identifier : AIDSLINE MED/20145401; Gatti G; Vigano' A; Sala N; Vella S; Bassetti M; Bassetti D; Principi N; Department of Infectious Diseases, University of Genoa, Genoa,; Italy. gigatti@smartino.ge.it; The indinavir dosage regimen currently used for human immunodeficiency virus (HIV)-infected children is not based on pharmacokinetic data obtained in the target patient population. The purpose of our study was to characterize indinavir pharmacokinetic
Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.: Antimicrob Agents Chemother. 2000 Mar;44(3):783-6. Unique Identifier : AIDSLINE MED/20145411; Stoddart CA; Moreno ME; Linquist-Stepps VD; Bare C; Bogan MR; Gobbi A; Buckheit RW Jr; Bedard J; Rando RF; McCune JM; Antiviral Drug Research Division, Gladstone Institute of Virology; and Immunology, San Francisco, California, USA.; cstoddart@gladstone.ucsf.edu; Oral administration of 2 -deoxy-3 -oxa-4 -thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine ( 3TC ), caused dose-dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus
Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260).: Antimicrob Agents Chemother. 2000 Mar;44(3):794-7. Unique Identifier : AIDSLINE +; Demeter LM; Shafer RW; Meehan PM; Holden-Wiltse J; Fischl MA; Freimuth WW; Para MF; Reichman RC; University of Rochester School of Medicine and Dentistry,; Rochester, New York, USA. Lisa_Demeter@urmc.rochester.edu; The development of human immunodeficiency virus type 1 resistance to delavirdine (DLV) was studied in subjects receiving DLV monotherapy. Phenotypic resistance developed in 28 of 30 subjects within 8 weeks. K103N and Y181C, which confer nonnucleoside
Dolichin, a new chitinase-like antifungal protein isolated from field beans (Dolichos lablab).: Biochem Biophys Res Commun. 2000 Mar 5;269(1):155-9. Unique Identifier : AIDSLINE MED/20160466; Ye XY; Wang HX; Ng TB; Department of Biochemistry, Chinese University of Hong Kong,; Shatin, N.T., Hong Kong, China.; An antifungal protein, possessing a molecular weight of 28 kDa and an N-terminal sequence resembling chitinases, has been purified from the seeds of the field bean Dolichos lablab. The procedure involved extraction with aqueous buffer, affinity chromatography on Affi-gel blue gel, and ion exchange chromatography on CM
Quinqueginsin, a novel protein with anti-human immunodeficiency virus, antifungal, ribonuclease and cell-free translation-inhibitory activities from American ginseng roots.: Biochem Biophys Res Commun. 2000 Mar 5;269(1):203-8. Unique Identifier : AIDSLINE MED/20160473; Wang HX; Ng TB; Department of Microbiology, China Agricultural University,; Beijing, China.; A homodimeric protein designated quinqueginsin, with a molecular weight of 53 kDa, has been isolated from the roots of American ginseng Panax quinquefolium. It was unadsorbed on DEAE cellulose in low ionic strength and neutral pH, and adsorbed on Affigel blue gel and SP-Sepharose under similar conditions. Its N-termin
Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir.: Biochem Pharmacol. 2000 May 1;59(9):1063-8. Unique Identifier : AIDSLINE MED/20170855; Lenhard JM; Weiel JE; Paulik MA; Furfine ES; Department of Metabolic Diseases, Glaxo Wellcome Inc., Research; Triangle Park, NC 27709, USA. jml29514@glaxowellcome.com; HIV protease inhibitors (PIs) are effective drugs for the treatment of AIDS. However, PI therapy is sometimes associated with side-effects including increased plasma lipids and altered body fat distribution, although fat redistribution may occur in some patients not
Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis.: Arthritis Rheum. 2000 Mar;43(3):617-27. Unique Identifier : AIDSLINE MED/20191100; Yudoh K; Matsuno H; Nakazawa F; Yonezawa T; Kimura T; Department of Orthopaedic Surgery, Toyama Medical and; Pharmaceutical University, Japan.; OBJECTIVE: To elucidate the involvement of the regulatory CD4+ T cells that produce high levels of interleukin-10 (IL-10) and low levels of IL-4 and IL-2 in the pathogenesis of rheumatoid arthritis (RA), we investigated whether the frequency of this type of CD4+ T cell
Psoriatic arthritis--an enthesopathy-based disorder? Comment on the article by McGonagle et al [letter]: Arthritis Rheum. 2000 Mar;43(3):712-4. Unique Identifier : AIDSLINE MED/20191117; Costello P; Kane D; Curran S; Bresnihan B; FitzGerald O; Winchester R
Docking of peptide-T onto the D1 domain of the CD4 receptor.: J Biomol Struct Dyn. 2000 Feb;17(4):725-33. Unique Identifier : AIDSLINE MED/20161935; Perez JJ; Filizola M; Corcho F; Dept. d'Enginyeria Quimica, UPC; ETS d'Enginyers Industrials,; Barcelona, Spain. juanje@eq.upc.es; Peptide T (pepT) is a segment of the human immunodeficiency virus (HIV) envelope protein gp120. The peptide competitively binds to the CD4 receptor of a subset of peripheral T lymphocytes and inhibits binding of gp120. Previous studies of this laboratory allowed the assessment of a bioactive form of the peptide and a
Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes.: AIDS. 2000 Jan 7;14(1):1-9. Unique Identifier : AIDSLINE MED/20177022; Ayyavoo V; Kudchodkar S; Ramanathan MP; Le P; Muthumani K; Megalai NM; Dentchev T; Santiago-Barrios L; Mrinalini C; Weiner DB; Department of Pathology & Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; OBJECTIVE: To develop an HIV-1 accessory gene immunogen using a DNA vaccine approach. METHODS: HIV-1 accessory genes vif, vpu and nef were modified to express under the control of a single promoter with cellular proteolytic cleavage sites between the coding sequences (VVN-P). Immune responses induced by these construc
In-vitro tipranavir susceptibility of HIV-1 isolates with reduced susceptibility to other protease inhibitors [letter]: AIDS. 2000 Jan 7;14(1):101-2. Unique Identifier : AIDSLINE MED/20177040; Back NK; van Wijk A; Remmerswaal D; van Monfort M; Nijhuis M; Schuurman R; Boucher CA
Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen. ACTG 375 team. AIDS Clinical Trials Group.: AIDS. 2000 Jan 7;14(1):11-21. Unique Identifier : AIDSLINE MED/20177023; Valdez H; Smith KY; Landay A; Connick E; Kuritzkes DR; Kessler H; Fox L; Spritzler J; Roe J; Lederman MB; Lederman HM; Evans TG; Heath-Chiozzi M; Lederman MM; Division of Infectious Diseases, Case Western Reserve University; School of Medicine and University Hospitals of Cleveland, Ohio; 44106, USA. valdez.hernan@clevelandactu.org; OBJECTIVES: To ascertain if immunization results in the restoration of responses to recall antigens, in the development of responses to presumed neoantigens, and to identify the virologic and immunologic correlates of these responses in persons with HIV-1 infection. DESIGN AND SETTING: Open-label study carried out at
Cellular proviral HIV-DNA decline and viral isolation in naive subjects with <5000 copies/ml of HIV-RNA and >500 x 10(6)/l CD4 cells treated with highly active antiretroviral therapy.: AIDS. 2000 Jan 7;14(1):23-9. Unique Identifier : AIDSLINE MED/20177024; Andreoni M; Parisi SG; Sarmati L; Nicastri E; Ercoli L; Mancino G; Sotgiu G; Mannazzu M; Trevenzoli M; Tridente G; Concia E; Aceti A; Department of Public Health, University of Rome Tor Vergata,; Italy. andreoni@uniroma2.it; OBJECTIVE: To evaluate the decay rate of cellular proviral HIV-DNA and viral replication in patients receiving highly active antiretroviral therapy (HAART) in the very early phase of infection. METHODS: Thirty-four patients treated with HAART and retrospectively selected for progressive decline of plasma viraemia up t
Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapy.: AIDS. 2000 Jan 7;14(1):31-6. Unique Identifier : AIDSLINE MED/20177025; Precious HM; Gunthard HF; Wong JK; D'Aquila RT; Johnson VA; Kuritzkes DR; Richman DD; Leigh Brown AJ; Centre for HIV Research, University of Edinburgh, Scotland.; OBJECTIVE: To determine whether analysis of sequence variation in reverse transcriptase at baseline can explain differences in response to combination antiretroviral therapy. METHODS: Amino acid sequences of reverse transcriptase obtained from baseline isolates from 55 patients included in a trial of zidovudine and di
Fat distribution evaluated by computed tomography and metabolic abnormalities in patients undergoing antiretroviral therapy: preliminary results of the LIPOCO study.: AIDS. 2000 Jan 7;14(1):37-49. Unique Identifier : AIDSLINE MED/20177026; Saint-Marc T; Partisani M; Poizot-Martin I; Rouviere O; Bruno F; Avellaneda R; Lang JM; Gastaut JA; Touraine JL; Transplantation and Clinical Immunology Unit, Edouard-Herriot; Hospital, Lyon, France. hiv.99@wanadoo.fr; BACKGROUND: Fat distribution abnormalities have been reported in patients treated with various antiretroviral drug regimens. The LIPOCO study is an ongoing observational study of unselected HIV-infected patients which aims to better characterize such disorders and their metabolic correlations. METHODS: Cross-sectional
Effect of ritonavir on lipids and post-heparin lipase activities in normal subjects.: AIDS. 2000 Jan 7;14(1):51-7. Unique Identifier : AIDSLINE MED/20177027; Purnell JQ; Zambon A; Knopp RH; Pizzuti DJ; Achari R; Leonard JM; Locke C; Brunzell JD; Department of Medicine, University of Washington, Seattle 98195,; USA. purnell@u.washington.edu; BACKGROUND: Intensive therapy of HIV infection with highly active antiretroviral therapy (HAART) dramatically reduces viral loads and improves immune status. Abnormalities of lipid levels, body fat distribution, and insulin resistance have been commonly reported after starting HAART. Whether the lipid abnormalities re
Toxicity and drug exposure in a quadruple drug regimen in HIV-1 infected patients participating in the ADAM study.: AIDS. 2000 Jan 7;14(1):59-67. Unique Identifier : AIDSLINE MED/20177028; Reijers MH; Weigel HM; Hart AA; Ten Kate RW; Mulder JW; Reiss P; Schuitemaker H; Hoetelmans RM; Weverling GJ; Lange JM; National AIDS Therapy Evaluation Center, Department of Internal; Medicine, Academic Medical Center, University of Amsterdam, The; Netherlands.; OBJECTIVE: To study the relationship between toxicity and the exposure to nelfinavir and saquinavir as part of a quadruple drug regimen. DESIGN: The ADAM study is a randomized study to investigate the feasibility of induction-maintenance therapy in HIV-1 infection. METHODS: HIV-1-infected patients with no prior use of
Changes in pathological findings at autopsy in AIDS cases for the last 15 years.: AIDS. 2000 Jan 7;14(1):69-74. Unique Identifier : AIDSLINE MED/20177029; Masliah E; DeTeresa RM; Mallory ME; Hansen LA; Department of Neurosciences, University of California, San Diego,; La Jolla 92093-0624, USA.; OBJECTIVE: To analyze changes in frequency of systemic AIDS pathology over time and its relationship to central nervous system pathology. DESIGN AND METHODS: A total of 390 AIDS autopsy cases obtained at University of California at San Diego Medical Center from 1982 to 1998 were reviewed retrospectively and linear reg
Overland heroin trafficking routes and HIV-1 spread in south and south-east Asia.: AIDS. 2000 Jan 7;14(1):75-83. Unique Identifier : AIDSLINE MED/20177030; Beyrer C; Razak MH; Lisam K; Chen J; Lui W; Yu XF; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA. cbeyrer@jhsph.edu; OBJECTIVES: Burma produces approximately 60% of the world s heroin, Laos is the third leading producer. Recent outbreaks of injecting drug use and HIV-1 in Burma,
Safety of multiple daily applications of COL-1492, a nonoxynol-9 vaginal gel, among female sex workers. COL-1492 Phase II Study Group.: Unique Identifier : AIDSLINE MED/20177031; Van Damme L; Chandeying V; Ramjee G; Rees H; Sirivongrangson P; Laga M; Perriens J; RATIONALE: COL-1492 is a nonoxynol-9 (N-9)-containing vaginal gel
Itraconazole as an alternative for ritonavir liquid formulation when combined with saquinavir [letter]: AIDS. 2000 Jan 7;14(1):89-90. Unique Identifier : AIDSLINE MED/20177032; Koks CH; van Heeswijk RP; Veldkamp AI; Meenhorst PL; Mulder JW; van der Meer JT; Beijnen JH; Hoetelmans RM
Coreceptor usage of HIV-1 after deletion of Gly317-Pro318-Gly319 motif in the gp120 V3 loop [letter]: AIDS. 2000 Jan 7;14(1):91-2. Unique Identifier : AIDSLINE MED/20177033; Su J; Vahlne A
The cytokine milieu of HIV-associated non-Hodgkin's lymphoma favours aggressive tumours [letter]: AIDS. 2000 Jan 7;14(1):92-4. Unique Identifier : AIDSLINE MED/20177034; Duff DK; Thompson S; Braye S; Price D; Loewenthal M; Boyle MJ
Is there really a correlation between AIDS dementia and Kaposi's sarcoma? [letter]: AIDS. 2000 Jan 7;14(1):94-5. Unique Identifier : AIDSLINE MED/20177035; Neuenburg JK; Brodt HR; Herndier BG; Schlote W
Are nelfinavir-containing regimens effective as second-line triple therapy? [letter]: AIDS. 2000 Jan 7;14(1):95-6. Unique Identifier : AIDSLINE MED/20177036; Bernasconi E; Magenta L; Piffaretti JC; Carota A; Moccetti T
Effect of interferon and ribavirin on HIV viral load [letter]: AIDS. 2000 Jan 7;14(1):96-7. Unique Identifier : AIDSLINE MED/20177037; Landau A; Batisse D; Piketty C; Kazatchkine MD
Induction of human herpesvirus-8 gene expression by recombinant interferon gamma [letter]: AIDS. 2000 Jan 7;14(1):98-9. Unique Identifier : AIDSLINE MED/20177038; Blackbourn DJ; Fujimura S; Kutzkey T; Levy JA
Pharmacokinetics of nelfinavir during haemodialysis in a patient with HIV infection [letter]: AIDS. 2000 Jan 7;14(1):99-101. Unique Identifier : AIDSLINE MED/20177039; Armbruster C; Vorbach H; El Menyawi I; Meisl FT; Neumann I
Low prevalence of antibodies and other plasma factors binding to CC chemokines and IL-2 in HIV-positive patients.: APMIS. 2000 Feb;108(2):122-30. Unique Identifier : AIDSLINE MED/20199718; Meyer CN; Svenson M; Schade Larsen C; Odum N; Skinhoj P; Bendtzen K; Institute for Inflammation Research, Rigshospitalet National; University Hospital, Copenhagen, Denmark.; Neutralizing cytokine antibodies are found in healthy and diseased individuals, including patients treated with recombinant cytokines. Identification of CCR-5 as co-receptor for HIV has focused interest on CC chemokines and their potential therapeutic use. Chemokine-binding components in plasma of HIV-infected patient
Update on the management of primary CNS lymphoma.: Oncology (Huntingt). 2000 Feb;14(2):228-34; discussion 237-42, 244. Unique Identifier : AIDSLINE MED/20201049; Nasir S; DeAngelis LM; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, New York, USA.; Primary central nervous system (CNS) lymphoma is a non-Hodgkin s lymphoma restricted to the nervous system. The incidence of this lymphoma is rising in the immunocompetent population but may be decreasing in patients with the acquired immune deficiency syndrome (AIDS) due to the in
Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes.: Br J Cancer. 2000 Mar;82(5):1058-62. Unique Identifier : AIDSLINE MED/20199650; Ogg GS; Dunbar PR; Cerundolo V; McMichael AJ; Lemoine NR; Savage P; MRC Human Immunology Unit, Institute of Molecular Medicine,; Oxford, UK.; A number of cell surface molecules with specificity to tumour cells have been identified and monoclonal antibodies (mAb) to some of these antigens have been used for targeting tumour cells in vivo. We have sought to link the powerful effector mechanisms of cytotoxic T-cells with the specificity of mAb, by targeting re
Experimental hypersensitivity pneumonitis: influence of Th2 bias.: Int J Exp Pathol. 1999 Dec;80(6):335-48. Unique Identifier : AIDSLINE MED/20098353; Schuyler M; Gott K; Mapel V; Cherne A; Nikula KJ; Department of Medicine, Albuquerque VA Medical Center, University; of New Mexico School of Medicine, Lovelace Respiratory Research; Institute, Albuquerque NM, USA.; Cultured murine CD4+ cells from Saccharopolyspora rectivirgula sensitized C3H/HeJ (Th1 bias) donors can adoptively transfer murine experimental hypersensitivity pneumonitis (EHP). We sensitized BALB/c mice (Th2 bias) with S. rectivirgula, obtained spleen and lung associated lymph node (LALN) cells, cultured the cells
Combined alpha interferon and ribavirin for the treatment of hepatitis C in patients with hereditary bleeding disorders.: Br J Haematol. 2000 Feb;108(2):254-8. Unique Identifier : AIDSLINE MED/20156056; Shields PL; Mutimer DJ; Muir D; Skidmore S; Britnell T; Roberts A; Wilde JT; The Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham;; Public Health Laboratory, Birmingham Heartlands Hospital,; Birmingham, UK.; Patients with hereditary bleeding disorders who received non-virally inactivated plasma-derived clotting factor concentrates before the mid-1980s invariably became infected with hepatitis C virus (HCV). Therapy with interferon alpha (IFN-alpha) alone has been disappointing in this group. We conducted an open-label stu
Recurrent B-cell non-Hodgkin's lymphoma in two brothers with X-linked lymphoproliferative disease without evidence for Epstein-Barr virus infection.: Br J Haematol. 2000 Feb;108(2):377-82. Unique Identifier : AIDSLINE MED/20156073; Strahm B; Rittweiler K; Duffner U; Brandau O; Orlowska-Volk M; Karajannis MA; Stadt Uz; Tiemann M; Reiter A; Brandis M; Meindl A; Niemeyer CM; University Children's Hospital, Freiburg, Germany.; strahm@kk1200.ukl.uni-freiburg.de; We present two male siblings suffering from recurrent manifestations of B-cell non-Hodgkin s lymphoma (NHL) and recurrent infections of the lower respiratory tract associated with bronchiectasis. Immunodeficiency could not be demonstrated by any laboratory investigation. In both pa
Therapy with thalidomide in refractory multiple myeloma patients the revival of an old drug.: Br J Haematol. 2000 Feb;108(2):391-3. Unique Identifier : AIDSLINE MED/20156075; Kneller A; Raanani P; Hardan I; Avigdor A; Levi I; Berkowicz M; Ben-Bassat I; The Institute of Haematology, The Chaim Sheba Medical Centre,; Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv; University, Israel.; We have treated 17 refractory or relapsed multiple myeloma patients resistant to chemotherapy with thalidomide at a dose of 200-800 mg/day. Eleven patients responded, five of whom had a very good partial response (> 75% decline in M protein) and another five exhibited a partial response (> 50% decline in M protein). E
Lamivudine allows completion of chemotherapy in lymphoma patients with hepatitis B reactivation.: Br J Haematol. 2000 Feb;108(2):394-6. Unique Identifier : AIDSLINE MED/20156076; Silvestri F; Ermacora A; Sperotto A; Patriarca F; Zaja F; Damiani D; Fanin R; Baccarani M; Division of Haematology, Department of Bone Marrow; Transplantation, University Hospital, Udine, Italy.; Reactivation of hepatitis B virus in patients receiving chemotherapy for non-Hodgkin s lymphoma (NHL) may give rise to hepatitis, hepatic failure and death, and prevent further chemotherapy. We report four patients with NHL in whom hepatitis flare-up was observed after two (three p
Life-threatening cutaneous reactions to thiacetazone-containing antituberculosis treatment in Kumasi, Ghana.: West Afr J Med. 1999 Oct-Dec;18(4):249-53. Unique Identifier : AIDSLINE MED/20198960; Lawn SD; Frimpong EH; Acheampong JW; Department of Medicine, School of Medical Sciences, University of; Science and Technology, Kumasi, Ghana.; Antituberculosis treatment containing thiacetazone is associated with a high incidence of life-threatening cutaneous drug reactions in patients infected with the human immunodeficiency virus (HIV). In order to develop a local policy concerning the use of this drug, a study was undertaken to determine the incidence of
Pulmonary tuberculosis in adults: factors associated with mortality at a Ghanaian teaching hospital.: West Afr J Med. 1999 Oct-Dec;18(4):270-4. Unique Identifier : AIDSLINE MED/20198965; Lawn SD; Acheampong JW; Division of Infectious Diseases, St. George's Hospital Medical; School, London, U.K.; Tuberculosis (TB) is a leading cause of global mortality. The aim of this study was to compare factors associated with poor outcome (death) and good outcome (cure) of adult patients receiving treatment for pulmonary TB (PTB) at the Komfo Anokye Teaching Hospital, Kumasi, Ghana . The
Understanding HIV risks of chronic drug-using men who have sex with men.: Unique Identifier : AIDSLINE MED/20180954; Rhodes F; Deren S; Wood MM; Shedlin MG; Carlson RG; Lambert EY; Kochems LM; Stark MJ; Falck RS; Wright-DeAguero L; Weir B; Cottler L; Rourke KM; Trotter RT 2nd; California State University, Long Beach 90813, USA.; Focus groups and individual structured interviews were conducted in six cities with 98 predominantly street-recruited men who had a recent history of smoking crack or injecting drugs and who reported having had sex with other men (MSM) in the past year. Twenty-six focus groups explored the cultural and social context
Differences in sexual behaviour between HIV-infected pregnant women and their husbands in Bangkok, Thailand.: AIDS Care. 1999 Dec;11(6):649-61. Unique Identifier : AIDSLINE MED/20180955; Bennetts A; Shaffer N; Phophong P; Chaiyakul P; Mock PA; Neeyapun K; Bhadrakom C; Mastro TD; Centers for Disease Control and Prevention, Atlanta, Georgia,; USA.; In a Bangkok antenatal clinic, we interviewed 102 HIV-infected pregnant women and their husbands, 30% of whom were HIV-negative. We evaluated these data by matched and unmatched analysis, compared men and women in stable couple relationships on a number of sociodemographic and risk factor indicators and investigated f
HIV testing practices of Zimbabwean physicians and their perspectives on the future use of rapid on-site tests.: AIDS Care. 1999 Dec;11(6):663-73. Unique Identifier : AIDSLINE MED/20180956; Gibney L; Wade S; Madzime S; Mbizvo M; University of Alabama, Birmingham, School of Public Health; 35294-0022, USA. lgibney@uab.edu; To improve HIV testing procedures, rapid on-site HIV tests have been introduced in Zimbabwe . At present, little is known about physicians perspectives on the potential use of rapid tests in their clinics or about their current laboratory-based testing practices. In a sample of 6
Effects of ZDV-based patient education on intentions toward ZDV use, HIV testing and reproduction among a US cohort of women.: AIDS Care. 1999 Dec;11(6):675-86. Unique Identifier : AIDSLINE MED/20180957; Healton C; Taylor S; Messeri P; Weinberg G; Bamji M; Columbia University, School of Public Health, New York, USA.; This study examined the immediate effects of exposure to a patient education brochure concerning the risks and benefits of zidovudine (ZDV) therapy during pregnancy to reduce perinatal HIV transmission (protocol ACTG 076) on related knowledge, behavioural intentions and attitudes of women with and at-risk for HIV-infe
Women's attitudes to condoms and female-controlled means of protection against HIV and STDs in south-western Uganda.: AIDS Care. 1999 Dec;11(6):687-98. Unique Identifier : AIDSLINE MED/20180958; Hart GJ; Pool R; Green G; Harrison S; Nyanzi S; Whitworth JA; MRC Social and Public Health Sciences Unit, University of; Glasgow, UK. graham@msoc.mrc.gla.ac.uk; The consistent and correct use of the male condom makes it highly effective in both disease prevention and as a contraceptive method. However, it is also well recognized that its use is under men s control. Because of this vital limitation, there have been frequent calls for female-controlled methods of HIV prevention
The impact of British and US guidelines for initiating combination antiretroviral therapy on estimating national treatment requirements for HIV-positive patients. Collaborating Immunologists and the Scottish HIV and AIDS Group.: AIDS Care. 1999 Dec;11(6):699-709. Unique Identifier : AIDSLINE MED/20180959; Parpia T; Raab GM; Goldberg DJ; Whitelaw J; Galloway E; Potts R; Applied Statistics Group, Napier University, Edinburgh, UK.; tamizap@udny.napier.ac.uk; This paper uses comprehensive national data on HIV positive patients in Scotland to carry out a needs assessment exercise for combination antiretroviral therapy. The objective of this study was to estimate the numbers of HIV positive patients in Scotland who would be eligible for combination antiretroviral therapy und
Adherence to antiretroviral therapy in HIV-infected children in Italy.: AIDS Care. 1999 Dec;11(6):711-4. Unique Identifier : AIDSLINE MED/20180960; Albano F; Spagnuolo MI; Berni Canani R; Guarino A; Department of Pediatrics, University Federico II, Naples, Italy.; alfguari@unina.it; Adherence to antiretroviral therapy is a major problem in children with HIV infection, who depend on parents or foster parents for receiving drugs. During an ongoing investigation on intestinal function in children with symptomatic HIV infection who were treated with zidovudine, blood samples were obtained six hours a
Orphans of the AIDS epidemic in the United States: transition-related characteristics and psychosocial adjustment at 6 months after mother's death.: AIDS Care. 1999 Dec;11(6):715-22. Unique Identifier : AIDSLINE MED/20180961; Forehand R; Pelton J; Chance M; Armistead L; Morse E; Morse PS; Stock M; University of Georgia, Athens 30602, USA. forehand@arches.uga.edu; This study has two purposes: (1) to describe the characteristics related to the transition to orphanhood for children whose mothers die from AIDS and (2) to examine the psychosocial adjustment of these children at six months following maternal death. Twenty orphans and a control sample of 40 children from the same nei
Predictors of dropout and burnout in AIDS volunteers: a longitudinal study.: AIDS Care. 1999 Dec;11(6):723-31. Unique Identifier : AIDSLINE MED/20180962; Ross MW; Greenfield SA; Bennett L; WHO Center for Health Promotion Research and Evaluation, School; of Public Health, University of Texas, Houston 77225, USA.; MROSS@utsph.sph.uth.tmec.edn; Burnout among HIV/AIDS volunteers contributes to the loss of dedicated personnel resulting in strain on the HIV/AIDS care system. Past research has suggested that there were significant stresses and burnout associated with AIDS caregiving. We investigated the predictors of dropout in AIDS volunteers over time, and spe
Preventing HIV infection through peer education and condom promotion among truck drivers and their sexual partners in Tanzania, 1990-1993.: AIDS Care. 2000 Feb;12(1):27-40. Unique Identifier : AIDSLINE MED/20180964; Laukamm-Josten U; Mwizarubi BK; Outwater A; Mwaijonga CL; Valadez JJ; Nyamwaya D; Swai R; Saidel T; Nyamuryekung'e K; African Medical and Research Foundation AMREF, Dar es Salaam,; Tanzania. ULaukamm@publichealthconsult.de; HIV prevention through peer education and condom promotion among truck drivers and their sexual partners is described. Trends during an initial 18-month intensive phase, followed by a 24-month maintenance phase, were monitored with surveys. Trends for self-reported condom use were: increase among men (56 to 74%) durin
Capturing the paradigm shift in HIV treatment: changing attitudes in the choice of combination antiretroviral drugs by high HIV caseload Australian GPs (1996-1997).: AIDS Care. 2000 Feb;12(1):41-7. Unique Identifier : AIDSLINE MED/20180965; Smith D; Goggin L; Meldrum H; Phillips S; Russell D; Bloch M; Bodsworth NJ; Roth N; Law MG; Community HIV Research Network, University of New South Wales,; Darlinghurst, Australia. don.smith@unsw.edu.av; The use of combination antiretroviral therapy for HIV infection is a rapidly changing field. To assess the impact of recent studies on prescribing patterns, two surveys of 21 high HIV caseload Australian GPs were undertaken in June 1996 and June 1997 to plot changes in the choice of combination antiviral therapy. Of t
Social and behavioural factors associated with HIV seroconversion in homosexual men attending a central London STD clinic: a feasibility study.: AIDS Care. 2000 Feb;12(1):49-58. Unique Identifier : AIDSLINE MED/20180966; Gilbart VL; Williams DI; Macdonald ND; Rogers PA; Evans BG; Hart G; Williams IG; PHLS AIDS and STD Centre, PHLS Communicable Disease Surveillance; Centre London, UK. vgilbart@phls.co.uk; An unmatched retrospective case control study was conducted to test the feasibility of investigating social and behavioural factors which may have contributed to recent HIV seroconversion in a group of homosexual men. Participants, recruited from a London sexually transmitted disease (STD) clinic, were sexually active
HIV prevention with young men who have sex with men: what young men themselves say is needed. Medical College of Wisconsin CITY Project Research Team.: AIDS Care. 2000 Feb;12(1):5-26. Unique Identifier : AIDSLINE MED/20180963; Seal DW; Kelly JA; Bloom FR; Stevenson LY; Coley BI; Broyles LA; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53202, USA. dseal@mcw.edu; Young men who have sex with men (YMSM), and particularly ethnic minority YMSM, experience high incidence HIV infection due to continued patterns of high-risk sexual behaviour. The intent of this research was to systematically solicit input and recommendations from YMSM themselves concerning the kinds of HIV prevention
HIV-infected adolescent and adult perceptions of tuberculosis testing, knowledge and medication adherence in the USA.: AIDS Care. 2000 Feb;12(1):59-63. Unique Identifier : AIDSLINE MED/20180967; Murphy DA; Rotheram-Borus MJ; Joshi V; Department of Psychiatry, University of California, Los Angeles,; USA. dmurphy@mednet.ucla.edu; HIV-infected adolescent and adult perceptions of tuberculosis (TB) infection rates and physician TB behaviour, and patient knowledge of TB transmission and treatment adherence were assessed. HIV-infected youth (N = 199) from adolescent clinical care sites in three cities and HIV-infected adults (N = 133) in New York w
HIV infection and patterns of risk among women drug injectors and crack users in low and high sero-prevalence sites.: AIDS Care. 2000 Feb;12(1):65-76. Unique Identifier : AIDSLINE MED/20180968; Tortu S; Beardsley M; Deren S; Williams M; McCoy HV; Stark M; Estrada A; Goldstein M; National Development and Research Institutes, Inc., New York, NY; 10048, USA. stephanie.tortu@ndri.org; As AIDS cases among US women continue to increase, a better understanding of women s behavioural risk patterns is needed to inform intervention efforts. Data were from 2,945 women drug injectors and crack users. Statistical analyses compared sociodemographic variables, lifetime behavioural risk patterns, HIV sero-prev
Gender differences in sharing injecting equipment by drug users in England.: AIDS Care. 2000 Feb;12(1):77-87. Unique Identifier : AIDSLINE MED/20180969; Bennett GA; Velleman RD; Barter G; Bradbury C; Addiction Service, Dorset HealthCare NHS Trust, Bournemouth.; GeraldBennett@Compuserve.com; The study investigates whether the higher rates of sharing needles and syringes reported by female injecting drug users (IDUs) also occur in sharing other types of injecting equipment. Structured interviews were carried out with 181 IDUs in two cities (100 in Bournemouth, 81 in Bath), with almost equal numbers of male
Doctors' attitudes to the care of children with HIV in South Africa.: AIDS Care. 2000 Feb;12(1):89-96. Unique Identifier : AIDSLINE MED/20180970; Fransman D; McCulloch M; Lavies D; Hussey G; Department of Paediatrics and Child Health, University of Cape; Town, South Africa. des@rmh.uct.ac.za; A descriptive survey was conducted on the attitudes of medical staff to caring for HIV-infected children, in three teaching hospitals in Cape Town, South Africa . The study was designed to determine whether the knowledge of a patient s HIV-positive status affects the doctor s attit
The effect of advance care planning on completion of advance directives and patient satisfaction in people with HIV/AIDS.: AIDS Care. 2000 Feb;12(1):97-108. Unique Identifier : AIDSLINE MED/20180971; Ho VW; Thiel EC; Rubin HR; Singer PA; University of Toronto, Ontario, Canada.; The effects of advance care planning are poorly understood. The purpose of this study was to evaluate the effect of an advance care planning intervention on the completion of advance directives (ADs) and patient satisfaction. A volunteer sample of persons with HIV/AIDS received advance directive documents, watched an
[Questions and answers on cryptococcal meningitis associated with human immunodeficiency virus infection]: Enferm Infecc Microbiol Clin. 2000 Feb;18(2):100-3. Unique Identifier : AIDSLINE MED/20186369; Arribas JR; Gonzalez-Garcia JJ; Pena JM; Vazquez JJ; Servicio de Medicina Interna (Unidad de VIH), Hospital; Universitario La Paz, Facultad de Medicina, Universidad Autonoma; de Madrid. arribas@nacom.es
[Micronodular pulmonary infiltration in a patient with acquired immunodeficiency syndrome]: Enferm Infecc Microbiol Clin. 2000 Feb;18(2):89-90. Unique Identifier : AIDSLINE MED/20186359; Tena D; Abad JC; Lizasoain M; Galan-Davila L; Sotelo T; Otero JR; Unidad de Enfermedades Infecciosas, Hospital 12 de Octubre,; Madrid.
[Hemophagocytic syndrome associated with cytomegalovirus and Mycobacterium xenopi disseminated disease in a patient infected by the human immunodeficiency virus who had a fatal outcome (letter)]: Enferm Infecc Microbiol Clin. 2000 Feb;18(2):96-7. Unique Identifier : AIDSLINE MED/20186365; Javier Nuno F; Noval J; Llorente R; Viejo G
[Bilateral tuberculous mastitis in a woman infected by the human immunodeficiency virus (letter)]: Enferm Infecc Microbiol Clin. 2000 Feb;18(2):98-9. Unique Identifier : AIDSLINE MED/20186367; Pardo J; Galindo I; Navarro LM; Querol R
Packageable antiviral therapeutics against human immunodeficiency virus type 1: virion-targeted virus inactivation by incorporation of a single-chain antibody against viral integrase into progeny virions.: Hum Gene Ther. 2000 Mar 1;11(4):537-46. Unique Identifier : AIDSLINE MED/20186599; Okui N; Sakuma R; Kobayashi N; Yoshikura H; Kitamura T; Chiba J; Kitamura Y; Division of Molecular Genetics, National Institute of Infectious; Diseases, Tokyo, Japan.; To determine their activities as an antiviral agent packageable within virions and suitable for continued expression in cells, we tested a single-chain antibody (scAb) against human immunodeficiency virus type 1 (HIV-1) integrase and its three fusion proteins: fused to viral protein R (scab-Vpr), a double-cassette of
Improved RPLC determination of acyclovir using hexylamine as silanol masking agent.: J Pharm Biomed Anal. 1999 Nov;21(3):619-24. Unique Identifier : AIDSLINE MED/20163364; Caamano MM; Garcia LV; Elorza B; Chantres JR; Department of Pharmaceutical Physical-Chemistry, Faculty of; Pharmacy, Universidad Complutense de Madrid, Spain.; mcaamano@worldonline.es; The aim of the present work is to improve the sensitivity in the RPLC determination of acyclovir [9-(2-hydroxy ethoxymethyl) guanine] (ACV) and guanine, the major impurity of the drug synthesis and one of the compounds found in the chemical degradation process of ACV. The method
Neutropenia, neutrophil dysfunction, and bacterial infection in patients with human immunodeficiency virus disease: the role of granulocyte colony-stimulating factor.: Clin Infect Dis. 2000 Feb;30(2):256-60. Unique Identifier : AIDSLINE MED/20137766; Kuritzkes DR; Division of Infectious Disease, University of Colorado Health; Sciences Center, Denver, CO 80262, USA.; daniel.kuritzkes@uchsc.edu; Neutropenia frequently complicates infection due to human immunodeficiency virus (HIV). The etiology of neutropenia in this setting includes bone marrow infection or infiltration, myelosuppressive therapies, the presence of antibodies to HIV, and accelerated apoptosis. Protection against microbial invaders by neutroph
Herpes simplex virus type 2 shedding in human immunodeficiency virus-negative men who have sex with men: frequency, patterns, and risk factors [see comments]: Clin Infect Dis. 2000 Feb;30(2):261-7. Unique Identifier : AIDSLINE MED/20137767; Krone MR; Wald A; Tabet SR; Paradise M; Corey L; Celum CL; Department of Biostatistics, University of Washington, Seattle,; WA, USA.; We investigated the frequency, site, and risk factors for herpes simplex virus (HSV) shedding in 30 human immunodeficiency virus (HIV)-negative HSV type 2 (HSV-2)-seropositive men who have sex with men. Subjects collected daily HSV culture samples from genital, perianal, and oral areas for 100 days and maintained diar
Early results (at 6 months) with intermittent clarithromycin-including regimens for lung disease due to Mycobacterium avium complex.: Clin Infect Dis. 2000 Feb;30(2):288-92. Unique Identifier : AIDSLINE MED/20137772; Griffith DE; Brown BA; Cegielski P; Murphy DT; Wallace Jr RJ; Department of Medicine, University of Texas Health Center, Tyler,; TX 75708, USA. griffith@uthct.edu; We initiated a prospective noncomparative trial of treatment for lung disease due to Mycobacterium avium complex (MAC) in human immunodeficiency virus-negative patients, with a regimen of clarithromycin (1000 mg), rifabutin (300-600 mg), and ethambutol (25 mg/kg) administered 3 times per week. Fifty-nine patients were
Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity.: Clin Infect Dis. 2000 Feb;30(2):313-8. Unique Identifier : AIDSLINE MED/20137776; Falloon J; Piscitelli S; Vogel S; Sadler B; Mitsuya H; Kavlick MF; Yoshimura K; Rogers M; LaFon S; Manion DJ; Lane HC; Masur H; National Institute of Allergy and Infectious Diseases, Bethesda,; MD, 20892-1880, USA. jfalloon@nih.gov; Patients with plasma viral RNA >50,000 copies/mL, despite a protease-inhibitor regimen, received abacavir , amprenavir, and efavirenz to assess efavirenz-amprenavir drug interactions and to evaluate safety and antiviral response. Patients first receive
Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy.: Clin Infect Dis. 2000 Feb;30(2):392-4. Unique Identifier : AIDSLINE MED/20137790; Garcia F; Vidal C; Plana M; Cruceta A; Gallart MT; Pumarola T; Miro JM; Gatell JM; Infectious Diseases Unit, Hospital Clinic, Faculty of Medicine,; University of Barcelona, Barcelona, Spain. fgarcia@medicina.ub.es; We report the evolution of chronic infection with human immunodeficiency virus type 1 (HIV-1) in a patient treated with stavudine plus didanosine, whose CD4+ lymphocyte count progressively decreased, despite a sustained plasma viral load
Central nervous system pneumocystosis in AIDS: antemortem diagnosis and successful treatment.: Clin Infect Dis. 2000 Feb;30(2):397-8. Unique Identifier : AIDSLINE MED/20137793; Vidal F; Miron M; Sirvent JJ; Richart C; Department Internal Medicine, Hospital Universitari de Tarragona; Joan XXIII, University Rovira i Virgili, Tarragona, Spain.; fvidal@galenics.com
Factors associated with incomplete virological response to highly active antiretroviral therapy [letter]: Clin Infect Dis. 2000 Feb;30(2):407-8. Unique Identifier : AIDSLINE MED/20137802; Welch K; Morse A; Clark R; Ogbuokiri T
Does hepatitis C virus really have no effect on survival in cases of infection with human immunodeficiency virus? [letter]: Clin Infect Dis. 2000 Feb;30(2):409-10. Unique Identifier : AIDSLINE MED/20137804; Jenny-Avital ER
A proportional hazards model for arbitrarily censored and truncated data.: Biometrics. 1996 Jun;52(2):512-24. Unique Identifier : AIDSLINE MED/20228726; Alioum A; Commenges D; INSERM U. 330, Universite de Bordeaux II, 146, rue Leo-Saignat,; 33076 Bordeaux Cedex, France.; Turnbull (1976, Journal of Royal Statistical Society, Series B 38, 290-295) proposed a method for nonparametric estimation of the distribution function when the data are incomplete because of censoring and truncation. However, as noted by Frydman (1994, Journal of Royal Statistical Society, Series B 56, 71-74), Turnbu
Oxidative stress response and signaling in hematological malignancies and HIV infection.: Int J Hematol. 2000 Jan;71(1):25-32. Unique Identifier : AIDSLINE MED/20194183; Masutani H; Institute for Virus Research, Kyoto University, Japan.; hmasutan@virus1.virus.kyoto-u.ac.jp; Hematopoietic cells can be exposed to a wide spectrum of oxidative stresses. Excessive oxidative stress damages biomolecules such as DNA, proteins, and lipids, leading to cellular dysfunction and cell death. Accumulation of such damage provokes noxious effects on individuals, resulting in diseases such as hematopoieti
Adult T-cell leukemia/lymphoma with initial deafness.: Int J Hematol. 2000 Jan;71(1):66-9. Unique Identifier : AIDSLINE MED/20194189; Harada Y; Shirota T; Hayashi T; Third Department of Internal Medicine, Tokyo Medical University,; Japan.; In July 1995, a 43-year-old Japanese man presented with deafness in the right ear. On hospital admission, he had deafness in both ears and right facial palsy. Variously sized lymphoid cells with convoluted nuclei were observed in the cerebrospinal fluid. Surface marker analysis revealed monoclonality of T lymphocytes
Mutations of the WASP gene in 10 Japanese patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia.: Int J Hematol. 2000 Jan;71(1):79-83. Unique Identifier : AIDSLINE MED/20194192; Itoh S; Nonoyama S; Morio T; Imai K; Okawa H; Ochs HD; Shimadzu M; Yata J; Department of Pediatrics, Tokyo Medical and Dental University,; Japan.; Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, immunodeficiency, and eczema. X-linked thrombocytopenia (XLT) is a mild form of WAS with isolated thrombocytopenia. Both phenotypes are caused by mutation of the Wiskott-Aldrich syndrome protein (WASP) gene. In this stu
Paronychia with pyogenic granuloma in a child treated with indinavir: the retinoid-mediated side effect theory revisited.: Dermatology. 2000;200(1):40-2. Unique Identifier : AIDSLINE MED/20148460; Sass JO; Jakob-Solder B; Heitger A; Tzimas G; Sarcletti M; Universitatskliniken fur Kinder- und Jugendheilkunde,; Innsbruck, Osterreich.; BACKGROUND: The introduction of HIV-1 protease inhibitors into the treatment of patients infected with HIV-1 has had a major influence on clinical practice. However, the use of protease inhibitors is frequently associated with the development of resistance and sever
A diffuse alveolar hemorrhage in a human T-lymphotropic virus type I carrier with acute cerebellar ataxia and interstitial pneumonitis: an autopsy case report.: Intern Med. 2000 Feb;39(2):166-9. Unique Identifier : AIDSLINE MED/20194977; Tajima M; Arioka H; Nakano J; Miyasaka T; Murata M; Yamashita N; Mano K; Sato T; Haebara H; Ohta K; Department of Medicine, Teikyo University School of Medicine,; Tokyo.; A 76-year-old HTLV-I-positive male with acute cerebellar ataxia was suffering from dyspnea on exertion. Chest CT suggested interstitial pneumonitis. Methylprednisolone pulse therapy improved his symptoms and chest CT findings. Twelve months after discharge, when the prednisolone dose was tapered to 5 mg every other da
Profile of cytokine production during the inhibition of acute xenograft rejection.: Surg Today. 2000;30(2):159-62. Unique Identifier : AIDSLINE MED/20129710; Kishimoto K; Furukawa K; Ashizuka S; Sawada T; Ayabe H; First Department of Surgery, Nagasaki University School of; Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.; Th2 cells have been shown to exert cell-mediated immune responses in vitro; therefore, the present study was conducted to investigate the cellular mechanisms of the long-term survival of cardiac xenografts by measuring cytokine production from recipient lymphocytes. Xenogeneic heart grafts from Lewis rats were transpl
HIV risk behaviours among gay men who use anabolic steroids.: Addiction. 1999 Dec;94(12):1829-35. Unique Identifier : AIDSLINE MED/20182424; Bolding G; Sherr L; Maguire M; Elford J; Department of Primary Care and Population Sciences, Royal Free; and University College Medical School, University College London,; UK.; AIMS: To examine the injecting and sexual risk behaviours of gay men in London who use anabolic steroids or other fitness-enhancing substances (referred to as AS). DESIGN: Cross-sectional survey using self-administered questionnaire. SETTING: Five gyms in central London. PARTICIPANTS: 1004 gay men using the gyms durin
Highly purified CD34+ cells isolated using magnetically activated cell selection provide rapid engraftment following high-dose chemotherapy in breast cancer patients.: Bone Marrow Transplant. 2000 Feb;25(3):243-9. Unique Identifier : AIDSLINE MED/20139354; Richel DJ; Johnsen HE; Canon J; Guillaume T; Schaafsma MR; Schenkeveld C; Hansen SW; McNiece I; Gringeri AJ; Briddell R; Ewen C; Davies R; Freeman J; Miltenyi S; Symann M; Medisch Spectrum Twente, Enschede, The Netherlands.; The primary objective of this study was to evaluate the safety of infusion of CD34+ cells, selected using a clinical scale magnetically activated cell sorting device, assessed by time to hematological engraftment and incidence of adverse events. Secondary objectives included evaluation of device performance in terms o
Unrelated peripheral blood stem cell transplantation with 'megadoses' of purified CD34+ cells in three children with refractory severe aplastic anemia.: Bone Marrow Transplant. 2000 Mar;25(5):513-7. Unique Identifier : AIDSLINE MED/20179505; Schwinger W; Urban C; Lackner H; Kerbl R; Benesch M; Dornbusch HJ; Sovinz P; Schauenstein K; Schumm M; Handgretinger R; Division of Pediatric Hematology/Oncology, Department of; Pediatrics, University of Graz, Austria.; Three children with refractory severe aplastic anemia were transfused with high numbers of unrelated matched (n = 2) or C-locus haploidentical mismatched (n = 1) CD34-selected peripheral blood stem cells in the absence of an HLA-identical family donor. Two leukaphereses of the donors yielded a median number of 10.1 x
High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis.: Bone Marrow Transplant. 2000 Mar;25(5):525-31. Unique Identifier : AIDSLINE MED/20179507; Kozak T; Havrdova E; Pit'ha J; Gregora E; Pytlik R; Maaloufova J; Mareckova H; Kobylka P; Vodvarkova S; Department of Clinical Haematology, University Hospital; Kralovske Vinohrady, Prague, Czech Republic.; High-dose immunoablative chemotherapy with autologous haematopoietic cell support might be beneficial in the treatment of intractable forms of MS. We mobilised PBPC in 11 patients with secondary progressive MS and finally eight patients were grafted after high-dose BEAM chemotherapy with either in vitro or in vivo T c
The Italian AIPO study on tuberculosis treatment results, report 1997. National AIPO "Tuberculosis" Study Group.: Monaldi Arch Chest Dis. 1999 Oct;54(5):407-12. Unique Identifier : AIDSLINE MED/20205273; Ambrosetti M; Besozzi G; Codecasa LR; Farris B; Nutini S; Saini L; Casali L; Nardini S; Migliori GB; Fondazione Salvatore Maugeri, Care and Research Institute,; Tradate, Italy.; In Italy no national data have been available on tuberculosis (TB) treatment results. In 1995 the AIPO (Italian Association of Hospital Pneumologists) TB Study Group, in collaboration with the Istituto Superiore di Sanita (technical branch of the Ministry of Health) started a prospe
[The monitoring of antitubercular drugs. Is it clinically useful? (editorial)]: Arch Bronconeumol. 2000 Feb;36(2):61-3. Unique Identifier : AIDSLINE MED/20190390; de Souza ML; Vidal R
Caring for African clients with HIV.: Nurs Manag (Harrow). 1999 Oct;6(6):14-7. Unique Identifier : AIDSLINE MED/20217676; King B; Palliative Care Centre, Camden & Islington NHS Trust, London.
Ex vivo T-lymphocyte derived cytokine production in SIRS patients is influenced by experimental procedures.: Shock. 2000 Mar;13(3):169-74. Unique Identifier : AIDSLINE MED/20181300; Muret J; Marie C; Fitting C; Payen D; Cavaillon JM; Department of Anaesthesia and Intensive Care Medicine, Hopital; Lariboisiere, Paris, France.; Ex vivo production of interleukin-2 ( IL-2 ), IL-4, IL-5, and IL-10 by peripheral blood mononuclear cells (PBMC) was studied in 13 septic patients with infectious systemic inflammatory response syndrome (SIRS) and 13 patients undergoing cardiac surgery with cardiopulmona
Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy.: Unique Identifier : AIDSLINE MED/20175804; Patton LL; McKaig R; Strauss R; Rogers D; Eron JJ Jr; OBJECTIVE: The purpose of this study was to determine temporal trends in the prevalence of oral manifestations of human immunodeficiency virus (HIV). STUDY DESIGN: Five hundred seventy HIV-infected adults recruited consecutively were examined by using established presumptive clinical criteria for HIV-associated oral l
Necrotizing ulcerative stomatitis in human immunodeficiency virus-seropositive individuals: a review of the histopathologic, immunohistochemical, and virologic characteristics of 18 cases.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Mar;89(3):323-32. Unique Identifier : AIDSLINE MED/20175809; Jones AC; Gulley ML; Freedman PD; Department of Pathology, The University of Texas Health Science; Center at San Antonio, USA. jonesac@uthscsa.edu; OBJECTIVE: The purpose of this retrospective study was to delineate the histopathologic, immunohistochemical, and virologic characteristics of 18 cases of necrotizing ulcerative stomatitis. STUDY DESIGN: Eighteen examples or oral ulcerations in human immunodeficiency virus-seropositive individuals were identified that
First, do no harm [editorial]: Trop Med Int Health. 2000 Feb;5(2):79-80. Unique Identifier : AIDSLINE MED/20211977; Hall AJ
Aggressive Kaposi's sarcoma in a 6-month-old African infant: case report and review of the literature.: Trop Med Int Health. 2000 Feb;5(2):85-7. Unique Identifier : AIDSLINE MED/20211979; Manji KP; Amir H; Maduhu IZ; Department of Paediatrics, Muhimbili University College of Health; Sciences, Dar-es-Salaam, Tanzania. kmanji@muchs.ac.tz; Kaposi s sarcoma (KS), known to exist in Africa for a century now, was rare in children and unknown in the newborn. With the onset of the HIV/AIDS epidemic, a more aggressive, disseminated type of KS (AKS) was recognized. Recently KS was diagnosed in a 6-month-old infant in Tanzania
[Disseminated encephalic cryptococcosis as a form of presentation of idiopathic T-CD4 lymphocytopenia]: Rev Neurol. 1999 Feb 16-28;28(4):390-3. Unique Identifier : AIDSLINE MED/20178698; Nunez MJ; de Lis JM; Rodriguez JR; Allegue MJ; Viladrich A; Conde C; Santiago MP; Amigo MC; Servicio de Medicina Interna, Hospital Montecelo, Pontevedra,; Espana.; INTRODUCTION: The term idiopathic T-CD4 lymphocytopenia is used to describe a new syndrome, defined as reduced T-CD4 lymphocytes in persons with no evidence of HIV infection or other causes which would explain the immunosuppression (secondary to neoplasties, immunosuppressive treatment, hereditary immunodeficiencies,
[Chronic inflammatory demyelinating polyneuropathy associated with prostatic adenocarcinoma]: Rev Neurol. 1999 Feb 16-28;28(4):394-6. Unique Identifier : AIDSLINE MED/20178699; Ramirez-Moreno JM; Gonzalez-Dorrego F; Seccion de Neurologia, Hospital Clinico Universitario Infanta; Cristina, Badajoz, Espana.; INTRODUCTION AND CLINICAL CASE: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired autoimmune disorder of unknown cause. CIDP most often occurs alone and not as a complication of other disorders but may accompany plasma cell dyscrasias, human immunodeficiency virus infection, systemic lupus erythe
HIV, infectious diseases, and competitive athletics.: Med Health R I. 2000 Feb;83(2):56-9. Unique Identifier : AIDSLINE MED/20194248; Feller AA; Flanigan TP; Dartmouth Medical School, USA.
Stopping vertical transmission of HIV: global strategies [editorial]: AIDS Patient Care STDS. 1999 Nov;13(11):635-7. Unique Identifier : AIDSLINE MED/20207909; Laurence J
National HIV strategy in Australia [letter]: AIDS Patient Care STDS. 1999 Nov;13(11):639. Unique Identifier : AIDSLINE MED/20207910; Ree H
Common head and neck manifestations of AIDS.: AIDS Patient Care STDS. 1999 Nov;13(11):641-4. Unique Identifier : AIDSLINE MED/20207911; Kim MK; Alvi A; Department of Otorhinolaryngology and Bronchoesophagology, Temple; University School of Medicine, Philadelphia, Pennsylvania, USA.; Michael@flower.aud.temple.edu; Head and neck manifestations of acquired immunodeficiency syndrome (AIDS) can involve the skin, ear, upper aerodigestive tract, and neck. Several head and neck manifestations of AIDS may be the only initial sign of this disease process and therefore primary-care physicians and otolaryngologists must be able to recogni
Thoracic lymphadenopathy in HIV patients: spectrum of disease and differential diagnosis.: AIDS Patient Care STDS. 1999 Nov;13(11):645-9. Unique Identifier : AIDSLINE MED/20207912; Fishman JE; Sagar M; Department of Radiology, University of Miami School of Medicine,; Jackson Memorial Hospital, Florida, USA.; jfishman@mednet.med.miami.edu; To evaluate the etiology and differential features of intrathoracic lymphadenopathy (LAD) in HIV patients, chest computed tomography (CT) records from an 18-month period were reviewed to identify all HIV-positive patients with intrathoracic LAD (nodal size > or = 1 cm). Medical records were reviewed for the documentat
Epidemiology of pediatric AIDS in Puerto Rico: 1981-1998.: AIDS Patient Care STDS. 1999 Nov;13(11):651-8. Unique Identifier : AIDSLINE MED/20207913; Perez-Perdomo R; Perez-Cardona CM; Suarez-Perez EL; University of Puerto Rico, Graduate School of Public Health, San; Juan. ros_perez@rcmaca.upr.clu.edu; The objective of this study was to describe the AIDS-defining conditions (ADC) and survival experience of pediatric AIDS cases (
Service delivery for patients with HIV in a rural state: the Vermont model.: AIDS Patient Care STDS. 1999 Nov;13(11):659-66. Unique Identifier : AIDSLINE MED/20207914; Grace CJ; Soons KR; Kutzko D; Alston WK; Ramundo M; Department of Medicine, Fletcher Allen Health Care, Burlington,; Vermont, USA. christopher.grace@vtmed-net.org; The incidence of human immunodeficiency virus (HIV) infection is increasing rapidly in rural areas of the United States . Barriers to health-care delivery for this patient population include the complexity of this rapidly changing field, inexperienced rural physicians, long travel dista
Demographic and attitudinal variables related to high-risk behaviors in Asian males who have sex with other men.: AIDS Patient Care STDS. 1999 Nov;13(11):667-75. Unique Identifier : AIDSLINE MED/20207915; Shapiro J; Vives G; University of California, Irvine College of Medicine, USA.; jfshapir@uci.edu; Although AIDS is spreading rapidly in minority communities, little is known about attitudes, knowledge, and behavior related to AIDS and HIV in the Asian community. The purpose of this study was to examine these variables in a sample of gay Asian males, as well as to investigate the relationship between knowledge, sou
HIV/AIDS case histories: diagnostic problems. Hemophagocytic syndrome.: AIDS Patient Care STDS. 1999 Nov;13(11):677-8. Unique Identifier : AIDSLINE MED/20207916; Pastore RD; Godwin JH; Department of Medicine, New York Presbyterian Hospital-Weill; Medical College of Cornell University, New York, USA.
Merck to launch vaccine trial [news]: AIDS Patient Care STDS. 1999 Nov;13(11):681. Unique Identifier : AIDSLINE MED/20207917
HHV-8 (KSHV) is not associated with bacillary angiomatosis.: Unique Identifier : AIDSLINE MED/20212356 P; Nayler SJ; Allard U; Taylor L; Cooper K
Pneumocystis carinii pneumonia (PCP) at Ga-Rankuwa Hospital.: Cent Afr J Med. 1999 May;45(5):127-9. Unique Identifier : AIDSLINE MED/20210495; Sein PP; Mzileni MO; Hoosen AA; Department of Medical Microbiology, Medical University of; Southern Africa, Medunsa, South Africa.; Pneumocystis carinii is recognized as one of the leading causes of death in AIDS patients in developed countries but its role in this regard in developing countries appears to be less prominent. Sub-Saharan African countries, in spite of their high HIV prevalence, have hardly recorded any cases. We report the first mi
The control of sexually transmitted diseases [editorial]: Cent Afr J Med. 1999 May;45(5):132-5. Unique Identifier : AIDSLINE MED/20210497; Latif AS; Marowa E
The HIV patient in general dental practice.: Prim Dent Care. 1999 Jan;6(1):29-32. Unique Identifier : AIDSLINE MED/20215937; Zakrzewska JM; Cushing A; Hall A; Koutantji M; Lewis D; School of Health Policy and Practice, University of East Anglia.; J.M.Zak@mds.qmw.ac.uk; General practitioners, especially those working in areas where there is a high incidence of HIV, will inevitably have to face patients who may or may not know that they are HIV antibody positive. This paper gives some guidelines on how to approach the problem, using two case scenarios.
Complexity of effector mechanisms in cyclosporine-induced syngeneic graft-versus-host disease.: Biol Blood Marrow Transplant. 2000;6(1):13-24. Unique Identifier : AIDSLINE MED/20170268; Hess AD; Thoburn CJ; Chen W; Horwitz LR; Division of Immunology and Hematopoiesis, Oncology Center, The; Johns Hopkins University, Baltimore, Maryland 21231, USA.; adhess@jhmi.edu; Administration of the immunosuppressive drug cyclosporine after syngeneic or autologous bone marrow transplantation elicits a T-lymphocyte-dependent autoimmune syndrome similar to graft-versus-host disease (GVHD). The onset of this autoaggression syndrome, termed syngeneic GVHD, is associated with the development of a
Communicable diseases surveillance highlight.: Commun Dis Intell. 2000 Jan 20;24(1):11-9. Unique Identifier : AIDSLINE MED/20198875
Surveillance data in CDI.: Commun Dis Intell. 2000 Jan 20;24(1):6-10. Unique Identifier : AIDSLINE MED/20198874
Offering HIV prophylaxis to people who have been sexually assaulted: 16 months' experience in a sexual assault service.: CMAJ. 2000 Mar 7;162(5):641-5. Unique Identifier : AIDSLINE MED/20202936; Wiebe ER; Comay SE; McGregor M; Ducceschi S; Department of Family Practice, University of British Columbia,; Vancouver. ewiebe@pop.interchange.ubc.ca; The sexual assault service, operated by the Children s & Women s Health Centre of British Columbia in partnership with the Vancouver General Hospital Emergency Department, started offering HIV prophylaxis in November 1996 to patients presenting to the emergency department after a sexual assault. In the first 16 mon
Africa's "future is frightening" because of HIV [news]: CMAJ. 2000 Mar 7;162(5):683, 686. Unique Identifier : AIDSLINE MED/20202945; Sibbald B
HIV prevention and homosexual men: should we be optimistic about the new millennium? [editorial]: Sex Transm Infect. 1999 Dec;75(6):369-71. Unique Identifier : AIDSLINE MED/20217736; Imrie J; Fenton KA; Billington A
Avoiding HIV transmission: women need more options [editorial]: Sex Transm Infect. 1999 Dec;75(6):374-5. Unique Identifier : AIDSLINE MED/20217739; Coggins C
Increasing prevalence of genital herpes in developing countries: implications for heterosexual HIV transmission and STI control programmes.: Sex Transm Infect. 1999 Dec;75(6):377-84. Unique Identifier : AIDSLINE MED/20217741; O'Farrell N; Department of Genitourinary Medicine, Bristol Royal Infirmary,; Bristol.; BACKGROUND: The recognition that sexually transmitted infections (STI) facilitate HIV transmission among heterosexuals has led to a rejuvenated focus on improving STI control as a component of HIV prevention programmes in developing countries. While efforts so far have focused mainly on all STI, there is increasing ev
Impact of HIV on adult (15-54) mortality in London: 1979-96.: Sex Transm Infect. 1999 Dec;75(6):385-8. Unique Identifier : AIDSLINE MED/20217742; Hickman M; Bardsley M; De Angelis D; Ward H; Centre for Research on Drugs and Health Behaviour, Social Science; and Medicine, Imperial College of Medicine, London.; OBJECTIVE: To describe the impact of HIV on mortality in men and women aged 15-54 in London. DESIGN: Combination of routine mortality statistics with reports of AIDS deaths adjusted for underreporting and change in address from time of report to time of death. Calculation of standardised mortality ratios (SMRs) for ma
Factors associated with the time elapsed between the initial detection of HIV-1 antibodies and a diagnosis of AIDS among patients followed in Lyons University Hospitals. CISIH Collaborators.: Sex Transm Infect. 1999 Dec;75(6):389-91. Unique Identifier : AIDSLINE MED/20217743; Vanhems P; Baratin D; Allard R; Marceillac E; Biron F; Cotte L; Saint-Marc T; Department of Epidemiology and Public Health, Claude Bernard; University, Lyon, France.; OBJECTIVE: To identify the factors associated with a short period between the initial detection of HIV-1 antibodies and AIDS diagnosis among patients from Lyons, France . DESIGN AND METHOD: Prospective hospital based cohort study of patients diagnosed with AIDS in Lyons University H
Viral subtype and heterosexual acquisition of HIV infections diagnosed in Scotland.: Sex Transm Infect. 1999 Dec;75(6):392-5. Unique Identifier : AIDSLINE MED/20217744; Yirrell DL; Goldberg DJ; Whitelaw J; McSharry C; Raeside F; Codere G; Centre for HIV Research, University of Edinburgh.; OBJECTIVE: As at December 1998, 87% of the estimated 33 million people living with HIV throughout the world resided in Africa and South East Asia. In Scotland (and the United Kingdom ), a major public health concern has been that non-B subtypes of HIV which predominate in the regions ab
Safety and acceptability of vaginal disinfection with benzalkonium chloride in HIV infected pregnant women in west Africa: ANRS 049b phase II randomized, double blinded placebo controlled trial. DITRAME Study Group.: Sex Transm Infect. 1999 Dec;75(6):420-5. Unique Identifier : AIDSLINE MED/20217752; Msellati P; Meda N; Leroy V; Likikouet R; Van de Perre P; Cartoux M; Bonard D; Ouangre A; Combe P; Gautier-Charpentier L; Sylla-Koko F; Lassalle R; Dosso M; Welffens-Ekra C; Dabis F; Mandelbrot L; Programme SIDA ORSTOM, Abidjan, Cote d'Ivoire.; OBJECTIVES: To study the tolerance and acceptability in Africa of a perinatal intervention to prevent vertical HIV transmission using benzalkonium chloride disinfection. DESIGN: A randomized, double blinded phase II trial. SETTING: Prenatal care units in Abidjan ( Cote d Ivoire
Syphilis serology and HIV infection in Harare, Zimbabwe.: Sex Transm Infect. 1999 Dec;75(6):426-30. Unique Identifier : AIDSLINE MED/20217753; Gwanzura L; Latif A; Bassett M; Machekano R; Katzenstein DA; Mason PR; Zimbabwe AIDS Prevention Project, Harare, Zimbabwe.; OBJECTIVE: To determine the reliability of serological tests in detecting syphilis in a factory worker cohort and examine the impact of concurrent HIV infection on serological tests for syphilis. METHOD: Reactions to non-treponemal and treponemal antigens were tested using sera from a cohort of 3401 factory workers in
Dry sex practices and HIV infection in the Dominican Republic and Haiti.: Sex Transm Infect. 1999 Dec;75(6):445-6. Unique Identifier : AIDSLINE MED/20217758; Halperin DT; Community Health Systems Department, University of California,; San Francisco 94143-0608, USA.
Biliary atresia in an infant born to an HIV positive mother [letter]: Sex Transm Infect. 1999 Dec;75(6):448. Unique Identifier : AIDSLINE MED/20217760; Ahmad S; Powell P
Late presentation of HIV infected patients at Amsterdam outpatient HIV clinics [letter]: Sex Transm Infect. 1999 Dec;75(6):448. Unique Identifier : AIDSLINE MED/20217759; Reedijk M; Bindels PJ; Wigersma L
Cost-effectiveness of universal compared with voluntary screening for human immunodeficiency virus among pregnant women in Chicago.: Unique Identifier : AIDSLINE MED/20209634; Immergluck LC; Cull WL; Schwartz A; Elstein AS; OBJECTIVES: To determine and compare the cost-effectiveness of implementing 3 screening strategies to detect human immunodeficiency virus (HIV) infection among pregnant women in Chicago, Illinois: no screening, voluntary screening, and universal screening. METHODS: A decision-analysis model was developed, using standa
Bronchiolitis obliterans organizing pneumonia (BOOP) in a case of smouldering adult T-cell leukaemia.: Respirology. 2000 Mar;5(1):81-5. Unique Identifier : AIDSLINE MED/20191081; Matsuo K; Tada S; Kataoka M; Kanehiro A; Kaneko S; Miyake T; Yamadori I; Harada M; Second Department of Internal Medicine, Okayama University; Medical School, Japan. kmkm@mqc.biglobe.ne.jp; Although various respiratory diseases have been reported in human T lymphotropic virus type-1 (HTLV-1) carriers or patients with adult T-cell leukaemia (ATL), there appears to be no report of the development of bronchiolitis obliterans organizing pneumonia (BOOP) in ATL or HTLV-1-related disorders. We describe a 51-ye
Acute tubulointerstitial nephritis attributable to indinavir therapy.: Am J Kidney Dis. 2000 Apr;35(4):E16. Unique Identifier : AIDSLINE MED/20207165; Jaradat M; Phillips C; Yum MN; Cushing H; Moe S; Departments of Medicine and Pathology, Indiana University School; of Medicine, Indianapolis, IN 46202, USA. mjaradat@iupui.edu; Indinavir sulfate has been reported to cause asymptomatic crystalluria and nephrolithiasis in patients with human immunodeficiency virus (HIV) infection. Patients taking indinavir may present with asymptomatic crystalluria, nephrolithiasis with frank
New treatment protocol including lympholytic and antiretroviral drugs to inhibit murine AIDS.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):107-13. Unique Identifier : AIDSLINE MED/20199685; Fraternale A; Tonelli A; Casabianca A; Chiarantini L; Schiavano GF; Celeste AG; Magnani M; Institute of Biological Chemistry Giorgio Fornaini, University of; Urbino, Italy.; Highly active antiretroviral therapy (HAART), although very efficient in reducing viral load to undetectable levels within 2 weeks, does not eradicate HIV-1 infection and after the suspension of therapy, HIV RNA rebounds to pretherapy levels. This limited efficacy is mainly due to the existence of viral reservoirs suc
Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):114-9. Unique Identifier : AIDSLINE MED/20199686; Lambotte O; Taoufik Y; de Goer MG; Wallon C; Goujard C; Delfraissy JF; Laboratory of Virus Neuron and Immunity, Bicetre Hospital, Le; Kremlin-Bicetre, France.; The existence of a reservoir of resting CD4+ T cells harboring latent replication-competent HIV has been demonstrated in patients on prolonged highly active antiretroviral therapy (HAART). Latently infected tissue macrophages may constitute a second HIV reservoir. The pool of these cells may be maintained by incoming
HIV-1 subtype C in commerical sex workers in Addis Ababa, Ethiopia.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):120-7. Unique Identifier : AIDSLINE GENBANK/AF160829; Hussein M; Abebe A; Pollakis G; Brouwer M; Petros B; Fontanet AL; de Wit TF; Ethiopian Health and Nutrition Research Institute, Addis Ababa.; ENARP@telecom.net.et; In this study, we have investigated the diversity of the current HIV-1 strains circulating in Addis Ababa, Ethiopia ; in addition, we have evaluated the applicability of peptide enzyme-linked immunosorbent assay (ELISA) and heteroduplex mobility assay (HMA) for HIV-1 subtyping. Pr
The SPICE study: 48-week activity of combinations of saquinavir soft gelatin and nelfinavir with and without nucleoside analogues. Study of Protease Inhibitor Combinations in Europe.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):128-37. Unique Identifier : AIDSLINE MED/20199688; Moyle G; Pozniak A; Opravil M; Clumeck N; DelFraissy JF; Johnson M; Pelgrom J; Reynes J; Vittecoq D; DeLora P; Salgo M; Duff F; The Kobler Clinic, Chelsea and Westminster Hospital, London, UK.; OBJECTIVES: To compare the efficacy and safety of saquinavir soft gelatin capsules (SQV-SGC) and nelfinavir (NFV), with or without two concomitant nucleoside reverse transcriptase inhibitors (NRTIs), in an exploratory objective to identify populations most likely to benefit from quadruple therapy. DESIGN: Phase II/III
Performance of five different assays for the quantification of viral load in persons infected with various subtypes of HIV-1. Swiss HIV Cohort Study.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):138-44. Unique Identifier : AIDSLINE MED/20199689; Burgisser P; Vernazza P; Flepp M; Boni J; Tomasik Z; Hummel U; Pantaleo G; Schupbach J; Division of Immunology and Allergy, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.; Philippe.Burgisser@chuv.hospvd.ch; Five methods for the assessment of plasma viral load (VL) were evaluated in 103 seropositive patients infected with various subtypes of HIV-1. The methods included three RNA-based assays (Amplicor Monitor 1.5, Quantiplex version 2.0, NucliSens), one ultrasensitive reverse transcriptase (PERT) assay and one boosted p
HIV-associated bacteremia: how it has changed in the highly active antiretroviral therapy (HAART) era.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):145-51. Unique Identifier : AIDSLINE MED/20199690; Tumbarello M; Tacconelli E; Donati KG; Citton R; Leone F; Spanu T; Cauda R; Department of Infectious Diseases, Catholic University, Rome,; Italy.; To evaluate the changing characteristics of HIV-associated bacteremia in the highly active antiretroviral therapy (HAART) era, we conducted a prospective case control study, comparing two periods of time, before (period A) and after (period B) the introduction of HAART. In total, 174 patients with bacteremia and 348 c
Molecular and virologic characteristics of lymphoid malignancies in children with AIDS.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):152-9. Unique Identifier : AIDSLINE MED/20199691; McClain KL; Leach CT; Jenson HB; Joshi VV; Pollock BH; Hutchison RE; Murphy SB; Baylor College of Medicine, Texas Children's Cancer Center,; Hematology Service, Houston, USA. kmcclain@txccc.org; PURPOSE: To characterize AIDS-associated lymphoid malignancies in children. PATIENTS AND METHODS: We studied lymphomas and B-cell leukemias from 25 children with AIDS for immunoglobulin heavy chain gene clonality, c-myc oncogene abnormalities, and presence of HIV and Epstein-Barr virus. RESULTS: Monoclonal immunoglobu
Causal pathways for CCR5 genotype and HIV progression.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):160-71. Unique Identifier : AIDSLINE MED/20199692; Taylor JM; Wang Y; Ahdieh L; Chmiel JS; Detels R; Giorgi JV; Kaslow R; Kingsley L; Margolick J; Department of Biostatistics, University of Michigan, Ann Arbor; 48109-0848, USA.; A homozygous 32-bp deletion in the gene encoding CCR5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1, and heterozygosity for the deletion is associated with delayed disease progression in persons infected with HIV-1. We investigated the effect of CCR5 heterozygosity on disease progression a
Course of viral load throughout HIV-1 infection.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):172-7. Unique Identifier : AIDSLINE MED/20199693; Sabin CA; Devereux H; Phillips AN; Hill A; Janossy G; Lee CA; Loveday C; Department of Primary Care, Royal Free Centre for HIV Medicine,; Royal Free and University College Medical School, London, UK.; caroline@rfhsm.ac.uk; HIV-1 RNA levels are routinely monitored as part of patient management. However, little is known about the course of HIV-1 RNA levels over the entire period of infection. The aim of this study was to investigate the course of HIV-1 RNA levels in a cohort of men with hemophilia who were observed for up to 17 years afte
Trends in prescriptions for highly active antiretroviral therapy in four New York City HIV clinics.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):178-83. Unique Identifier : AIDSLINE MED/20199694; Sackoff JE; McFarland JW; Shin SS; New York City Department of Health, Office of AIDS Surveillance,; New York 10013, USA.; OBJECTIVE: To describe trends in prescriptions for antiretroviral therapies and factors associated with prescriptions for highly active antiretroviral therapy (HAART). METHODS: Medical records of patients at four HIV clinics in New York City were reviewed every 6 months. For the four 6-month periods 1997 to 1998, we i
HIV-1 diversity in Brazil: genetic, biologic, and immunologic characterization of HIV-1 strains in three potential HIV vaccine evaluation sites. Brazilian Network for HIV Isolation and Characterization.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):184-93. Unique Identifier : AIDSLINE GENBANK/AF062425; Bongertz V; Bou-Habib DC; Brigido LF; Caseiro M; Chequer PJ; Couto-Fernandez JC; Ferreira PC; Galvao-Castro B; Greco D; Guimaraes ML; Linhares de Carvalho MI; Morgado MG; Oliveira CA; Osmanov S; Ramos CA; Rossini M; Sabino E; Tanuri A; Ueda M; Departamento de Imunologia, Instituto Oswaldo Cruz, Fundacao; Oswaldo Cruz, Rio de Janeiro, Brazil.; The Brazilian Network for HIV Isolation and Characterization was established for the surveillance of HIV variability in Brazil. Here, we report characterization of HIV strains and virus-specific immune responses from 35 clinical samples collected from three potential HIV vaccine sites. Three genetic subtypes of HIV-1
HIV incidence and HIV-associated mortality in a cohort of factory workers and their spouses in Tanzania, 1991 through 1996.: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):194-202. Unique Identifier : AIDSLINE MED/20199696; Senkoro KP; Boerma JT; Klokke AH; Ng'weshemi JZ; Muro AS; Gabone R; Borgdorff MW; National Institute for Medical Research, Mwanza, Tanzania.; OBJECTIVE: To describe HIV incidence and HIV-associated mortality in a cohort of factory workers and their spouses with access to adequate sexually transmitted diseases (STD) treatment services and moderate exposure to sexual health interventions. METHODS: Follow-up visits at 4-month intervals and home follow-up of th
HIV and HTLV prevalences among women seen for sexually transmitted diseases or pregnancy follow-up in Maputo, Mozambique [letter]: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):203-4. Unique Identifier : AIDSLINE MED/20199697; Melo J; Beby-Defaux A; Faria C; Guiraud G; Folgosa E; Barreto A; Agius G
Comparison of simultaneous active and passive AIDS case reporting in San Francisco [letter]: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):204-5. Unique Identifier : AIDSLINE MED/20199698; Hsu L; Schwarcz S; Katz M
Evidence of HIV-1 genetic diversity among pregnant women with AIDS or infected with HIV-1 in Central Brazil [letter]: J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):205-7. Unique Identifier : AIDSLINE MED/20199699; Stefani MM; Pereira GA; Martelli CM; Shindo N; Galvao-Castro B
[Encouraging study results. HIV from birth on--virostatic drugs can decrease the risk]: MMW Fortschr Med. 1999 Aug 26;141(34):61. Unique Identifier : AIDSLINE MED/20190336
[HIV: interleukin 2 supports the immune system (news)]: MMW Fortschr Med. 1999 Dec 9;141(49-50):24. Unique Identifier : AIDSLINE MED/20190341; Moser-Junemann C; Jager H
Some current obstetric and gynaecological problems.: Baillieres Best Pract Res Clin Obstet Gynaecol. 1999 Dec;13(4):449-72. Unique Identifier : AIDSLINE MED/20180586; Friend JR; Department of Reproductive Medicine, Derriford Hospital,; Plymouth, Devon, UK.; It has never been right to practise obstetrics and gynaecology in a purely mechanistic style. Medical practitioners have always discussed and argued, often driven by their patients, both the ethical framework and the individual circumstantial detail of practice within this specialty. This chapter starts by discussing
A feasibility study of adolescent sex education: medical students as peer educators in Edinburgh schools [letter]: BJOG. 2000 Mar;107(3):436. Unique Identifier : AIDSLINE MED/20201632; Sundar M
Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.: Cytogenet Cell Genet. 1999;87(3-4):265-8. Unique Identifier : AIDSLINE MED/20169206; Maho A; Bensimon A; Vassart G; Parmentier M; IRIBHN, Universite Libre de Bruxelles, Campus Erasme, Brussels,; Belgium.; Human CC-chemokine receptor genes are known to be clustered. The detailed structure of this cluster was established by radiation hybrid mapping, and organization of BAC contigs by fluorescence hybridization on combed genomic DNA. A main cluster of six genes (CCR1, CCR3, CCRL2, CCR5, CCR2 and CCXCR1), covered by four B
[Human immunodeficiency virus infection among gynecology and obstetrics patients]: Chung Hua Fu Chan Ko Tsa Chih. 1998 Apr;33(4):246-8. Unique Identifier : AIDSLINE MED/20147054; Tang X; Zhong J
Symptomatic HIV-infection in infants according to serostatus of mothers during pregnancy.: East Afr Med J. 1999 Oct;76(10):566-70. Unique Identifier : AIDSLINE MED/20198682; Olayinka BA; Obi CL; Department of Obstetrics and Gynaecology, Faculty of Medicine,; University of Zimbabwe, Harare, Zimbabwe.; OBJECTIVE: To ascertain the pattern of symptomatic HIV infections, HIV seropositivity and mother to child transmission (MTCT) rate during a two-year follow up period at 6, 12, 18, and 24 months according to mothers serostatus during pregnancy. DESIGN: A longitudinal cohort study with socio-economic, medical, and demog
Severe malnutrition due to subtle neurologic deficits and epilepsy: report of three cases.: East Afr Med J. 1999 Oct;76(10):597-8. Unique Identifier : AIDSLINE MED/20198690; Dike GL; UCLA-Department of Medicine 90095-1736, USA.; In southern and eastern Africa, where approximately eight per cent of households lack access to adequate food, children suffering from chronic infections such as tuberculosis, gastrointestinal parasites and human immunodeficiency virus, often present with severe protein energy malnutrition. Three cases are described o
Re: Sexual life of medical students [letter]: East Afr Med J. 1999 Nov;76(11):658. Unique Identifier : AIDSLINE MED/20198706; Szepesvari R; Settergren M; Kasesela S; Mabiriizi D; Mwaiselage J; Mwisongo A; Massawe S; Swai A; Rosling H
Anti-HIV activity of extracts and compounds from algae and cyanobacteria.: Ecotoxicol Environ Saf. 2000 Mar;45(3):208-27. Unique Identifier : AIDSLINE MED/20169218; Schaeffer DJ; Krylov VS; Department of Veterinary Biosciences, University of Illinois,; 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA.; The human immunodeficiency virus (HIV) is the retrovirus that causes the acquired immune deficiency disease syndrome (AIDS). This review discusses the anti-HIV activity of extracts and compounds isolated from freshwater and marine algae, and cyanobacteria (formerly called blue-green algae ). Compounds and extracts wi
Localized Mycobacterium genavense soft tissue infection in an immunodeficient HIV-negative patient.: Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):51-2. Unique Identifier : AIDSLINE MED/20168698; Leautez S; Boutoille D; Bemer-Melchior P; Ponge T; Raffi F; Service de Medecine Interne B, Maladies Infectieuses, CHU Hotel; Dieu, Place Alexis Ricordeau, Nantes, France.; An HIV-negative woman with chronic lymphopenia related to past sarcoidosis situated in the bone marrow presented with an inflammatory lesion in the iliac region due to a localized Mycobacterium genavense soft tissue infection. The lesion resolved after 12 months of antibiotic therapy with clarithromycin, ethambutol an
Severe cytomegalovirus-triggered autoimmune hemolytic anemia complicating vertically acquired HIV infection.: Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):57-60. Unique Identifier : AIDSLINE MED/20168700; Hausler M; Schaade L; Hutschenreuter G; Hannig U; Kusenbach G; Department of Pediatrics, University Hospital, RWTH, Aachen,; Germany.; The association of acute cytomegalovirus infection with severe autoimmune hemolysis has not yet been reported in patients with HIV infection. The case is described of a 9-month-old infant with congenital HIV-1 infection who presented with severe autoimmune hemolysis and a high cyto
Mycobacterium kansasii abscess of the chest wall after drainage of bacterial empyema.: Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):72-3. Unique Identifier : AIDSLINE MED/20168705; Tietz A; Tamm M; Battegay M; Medical Outpatient Department, University Hospital Basel,; Switzerland. tietz@hotmail.com
Sexual partnership patterns as a behavioral risk factor for sexually transmitted diseases.: Fam Plann Perspect. 1999 Sep-Oct;31(5):228-36. Unique Identifier : AIDSLINE MED/20188626; Finer LB; Darroch JE; Singh S; Alan Guttmacher Institute, New York, USA.; CONTEXT: Women s and men s number of sexual partners and protective practices such as condom use can have a direct effect on their risk of contracting sexually transmitted diseases (STDs), including HIV. METHODS: The 1988 and 1995 cycles of the National Survey of Family Growth and five rounds of the General Social Sur
A rev-like NES mediates cytoplasmic localization of HERV-K cORF.: FEBS Lett. 2000 Feb 18;468(1):65-7. Unique Identifier : AIDSLINE MED/20148611; Boese A; Sauter M; Mueller-Lantzsch N; Institut fur Mikrobiologie und Hygiene, Abteilung Virologie,; Haus 47, Universitatskliniken, D-66421, Homburg/Saar, Germany.; The human endogenous retrovirus K (HERV-K)-encoded protein cORF has recently been shown to be a functional homolog of the HIV Rev protein. Rev-mediated RNA export requires interaction between a leucine-rich nuclear export signal (NES) in Rev and the nuclear export receptor Crm1/exportin1. Like Rev, cORF binds to Crm1
Retinoic acid stimulates HIV-1 transcription in human neuroblastoma SH-SY5Y cells.: FEBS Lett. 2000 Mar 3;469(1):118-22. Unique Identifier : AIDSLINE MED/20175423; Recio JA; Martinez de la Mata J; Martin-Nieto J; Aranda A; Instituto de Investigaciones Biomedicas 'Alberto Sols', Consejo; Superior de Investigaciones Cientificas and Universidad; Autonoma de Madrid, Arturo Duperier 4, 28029, Madrid, Spain.; Although the brain is an important target for the human immunodeficiency virus type 1 (HIV) and viral infection causes neuronal degeneration and dementia , the mechanisms responsible for HIV transcription in neuronal cells are largely unknown. We show here that retinoic acid (RA) st
Efficacy and safety of trazodone versus clorazepate in the treatment of HIV-positive subjects with adjustment disorders: a pilot study.: J Int Med Res. 1999 Sep-Oct;27(5):223-32. Unique Identifier : AIDSLINE MED/20154218; De Wit S; Cremers L; Hirsch D; Zulian C; Clumeck N; Kormoss N; Department of Infectious Diseases, Saint-Pierre University; Hospital, Brussels, Belgium.; The efficacy of trazodone and clorazepate to relieve anxiety and depressive symptoms in 21 HIV-positive subjects with adjustment disorders was determined in a 28-day single-centre, randomized, double-blind study. Subjects were evaluated using the Hospital Anxiety and Depression Scale, the Revised Symptom Checklist, th
P-glycoprotein-overexpressing multidrug-resistant cells are resistant to infection by enveloped viruses that enter via the plasma membrane.: FASEB J. 2000 Mar;14(3):511-5. Unique Identifier : AIDSLINE MED/20164492; Raviv Y; Puri A; Blumenthal R; Intramural Research Support Program SAIC Frederick, Laboratory of; Experimental and Computational Biology, National Cancer; Institute, Frederick, MD 21702, USA. yraviv@mail.ncifcrf.gov; The multidrug resistance gene product P-glycoprotein confers drug resistance to tumor cells by acting as a transporter that blocks the entry into the cell of a great variety of drugs and hydrophobic peptides. In this study we find that in drug-resistant cells, the insertion of the influenza virus fusion protein (hemag
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.: FASEB J. 2000 Mar;14(3):516-22. Unique Identifier : AIDSLINE MED/20164493; Lee CG; Ramachandra M; Jeang KT; Martin MA; Pastan I; Gottesman MM; Laboratory of Cell Biology, Laboratory of Molecular Biology,; National Cancer Institute, Laboratory of Molecular Microbiology,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892, USA.; The MDR1 multidrug transporter P-gp (P-glycoprotein) is an efflux pump that extrudes diverse hydrophobic drugs and peptides from cells. Since the entry of HIV-1 into cells involves an initial interaction of the viral gp41 hydrophobic peptide with the plasma membrane, a potential effect of P-gp on HIV-1 infectivity was
Chromatin control of HIV-1 gene expression.: Genetica. 1999;106(1-2):125-30. Unique Identifier : AIDSLINE MED/20176053; Marzio G; Giacca M; Molecular Medicine Laboratory, International Centre for Genetic; Engineering and Biotechnology (ICGEB), Trieste, Italy.; Upon infection of susceptible cells, the RNA genome of the human immunodeficiency virus type 1 (HIV-1) is reverse transcribed into double-stranded DNA, which can be subsequently integrated into the cellular genome. After integration, the viral long terminal repeat (LTR) promoter is present in a nucleosome-bound confor
Large artery vasculopathy in HIV-positive patients: another vasculitic enigma.: Hum Pathol. 2000 Mar;31(3):374-9. Unique Identifier : AIDSLINE MED/20208471; Chetty R; Batitang S; Nair R; Department of Pathology, University of Natal School of Medicine,; Durban, South Africa.; Human immunodeficiency virus (HIV) infection has impacted on all the systems of the body, and the cardiovascular system is no exception, with small to medium-sized vessel vasculitis being most frequently described. We present 16 HIV-positive patients with large vessel disease consisting of either aneurysms (often mult
Different roles for LFA-1 and VLA-4 integrins in T-B-cell interactions in vivo.: Immunology. 1999 Jul;97(3):438-46. Unique Identifier : AIDSLINE MED/20196260; Lopez-Hoyos M; Revilladagger C; Conde C; Del Campo EG; Gonzalez A; Merino J; Immunology Unit, Hospital Universitario Marques de Valdecilla,; Spain.; Adhesion molecules are critical in the cellular interactions involved in specific immune responses. They are used for homing, cell migration, cell-cell contact and, in some cases, for the delivery of costimulatory signals. Since the host-versus-graft (HVG) reaction represents a particular form of T-B-cell interaction,
Interleukin-12-secreting fibroblasts are more efficient than free recombinant interleukin-12 in inducing the persistent resistance to Mycobacterium avium complex infection.: Unique Identifier : AIDSLINE MED/20196265; Kang BY; Chung SW; Lim YS; Kim EJ; Kim SH; Hwang SY; Kim TS; College of Pharmacy, Chonnam National University, Kwangju, Korea.; To determine whether the paracrine secretion of interleukin-12 (IL-12) can efficiently stimulate the resistance to Mycobacterium avium complex (MAC) infection, 3T3 fibroblasts were stably transfected to secrete IL-12 (480 U/106 cells/48 hr) and their effect on MAC infection was investigated in genetically susceptible
Depletion of CD8+ cells abolishes memory in acquired immunity against Chlamydia pneumoniae in BALB/c mice.: Immunology. 1999 Jul;97(3):490-6. Unique Identifier : AIDSLINE MED/20196267; Penttila JM; Anttila M; Varkila K; Puolakkainen M; Sarvas M; Makela PH; Rautonen N; Department of Vaccines, National Public Health Institute,; Helsinki, Finland.; The importance of T cells in Chlamydia pneumoniae infection in mice was assessed by comparing wild-type BALB/c mice with nude mice and mice depleted in vivo of either CD4+ or CD8+ T cells. Whereas wild-type mice cleared the primary infection in 3 weeks, nude mice were only able to restrict the infection and could not
UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses.: Immunology. 1999 Jul;97(3):506-14. Unique Identifier : AIDSLINE MED/20196269; Garssen J; Vandebriel RJ; De Gruijl FR; Wolvers DA; Van Dijk M; Fluitman A; Van Loveren H; Laboratory for Pathology and Immunobiology, National Institute of; Public Health and The Environment, Bilthoven, the Netherlands.; Exposure to ultraviolet light, especially UVB wavelengths, can impair immune responses in animals and humans. It is remarkable that this immunomodulation is not restricted to the exposed skin but is also found at other sites, i.e. systemic (distant) immunosuppression. A frequently proposed hypothesis is that UVB expos
A recombinant BCG vaccine generates a Th1-like response and inhibits IgE synthesis in BALB/c mice.: Immunology. 1999 Jul;97(3):515-21. Unique Identifier : AIDSLINE MED/20196270; Kumar M; Behera AK; Matsuse H; Lockey RF; Mohapatra SS; Joy McCann Culverhouse, Airway Disease Research Center, Division; of Allergy and Immunology, Department of Internal Medicine, VA; Hospital, Tampa, FL 33612, USA.; The tubercle vaccine, bacille Calmette-Guerin (BCG), is a strong inducer of T-helper type 1 (Th1) responsiveness, and it has been suggested that recombinant BCG (rBCG), which produces and secretes antigens, may be used to prevent allergic diseases. The effects of rBCG vaccination on allergic responses in a murine mode
An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells.: Immunology. 2000 Mar;99(3):375-84. Unique Identifier : AIDSLINE MED/20177724; Muller B; Fischer B; Kreutz W; Institut fur Biophysik und Strahlenbiologie,; Albert-Ludwigs-Universitat Freiburg, Freiburg i. Br., Germany.; The microenvironment within solid tumours has often been shown to exhibit an acidic local pH. In recent studies we could demonstrate that an acidic extracellular pH (pHe) inhibits the non-major histocompatibility complex (MHC) -restricted cytotoxicity of immunocompetent effector cells. However, within tumours the acti
Differential effects of CD4 and CD8 engagement on the development: Unique Identifier : AIDSLINE MED/20177726 P
CXC chemokine receptor 4 expression and stromal cell-derived factor-1alpha-induced chemotaxis in CD4+ T lymphocytes are regulated by interleukin-4 and interleukin-10.: Immunology. 2000 Mar;99(3):402-10. Unique Identifier : AIDSLINE MED/20177727; Jinquan T; Quan S; Jacobi HH; Madsen HO; Glue C; Skov PS; Malling HJ; Poulsen LK; Laboratory of Medical Allergology, Allergy Unit, and Laboratory; of Tissue Typing, Department of Clinical Immunology, National; University Hospital, Copenhagen, Denmark.; We report that interleukin (IL)-4 and IL-10 can significantly up- or down-regulate CXC chemokine receptor 4 (CXCR4) expression on CD4+ T lymphocytes, respectively. Stromal cell-derived factor-1alpha (SDF-1alpha)-induced CD4+ T-lymphocyte chemotaxis was also correspondingly regulated by IL-4 and IL-10. IL-4 and IL-10 u
A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function-associated antigen-1 functional association in humans.: Immunology. 2000 Mar;99(3):440-50. Unique Identifier : AIDSLINE GENBANK/AF016894; Allende LM; Hernandez M; Corell A; Garcia-Perez MA; Varela P; Moreno A; Caragol I; Garcia-Martin F; Guillen-Perales J; Olive T; Espanol T; Arnaiz-Villena A; Department of Immunology, Hospital '12 de Octubre', Universidad; Complutense de Madrid, Madrid, Spain.; Leucocyte adhesion deficiency (LAD) is an autosomal-recessive genetic disease that is characterized clinically by severe bacterial infections and caused by mutations in the CD18 gene that codes for the beta2 integrin subunit. A patient with a severe LAD phenotype was studied and the molecular basis of the disease was
Induction of T helper 1- and T helper 2-type immune responses during Haemonchus contortus infection in sheep.: Immunology. 2000 Mar;99(3):458-63. Unique Identifier : AIDSLINE MED/20177734; Gill HS; Altmann K; Cross ML; Husband AJ; Department of Animal Science, University of New England,; Armidale, NSW, Australia.; The production of cytokines by lymphoid cells, isolated from non-infected and Haemonchus contortus-infected lambs, was investigated. Particular attention was paid to differences in T helper 1- (Th1) and Th2-type immune profiles between genetically resistant and random-bred animal groups. Non-infected resistant and ran
Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection.: Immunology. 2000 Mar;99(3):464-72. Unique Identifier : AIDSLINE MED/20177735; Bao S; Beagley KW; France MP; Shen J; Husband AJ; Department of Veterinary Anatomy and Pathology, The University of; Sydney, Sydney, NSW, Australia.; Salmonella bacteria are a major cause of food-borne infectious diarrhoea and there is great interest in understanding the pathogenesis of Salmonella infection and in vaccine development. Potential vaccines include the aromatic mutants of S. typhimurium. Such non-lethal Aro mutants have also been useful for studying Sa
Brain-immune connection: immuno-regulatory properties of CNS-resident cells.: Glia. 2000 Feb 15;29(4):293-304. Unique Identifier : AIDSLINE MED/20119213; Becher B; Prat A; Antel JP; Department of Microbiology, Dartmouth Medical School, Lebanon,; New Hampshire 03756, USA. burkhard.becher@dartmouth.edu; Even though the immune privileged status of the central nervous system (CNS) limits access of systemic immune cells through the blood brain barrier (BBB), an immune response can occur in this compartment with or without major breach of the BBB. In this review, we consider properties of resident cells of the CNS, that
Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation.: Glia. 2000 Feb 15;29(4):305-15. Unique Identifier : AIDSLINE MED/20119214; Zujovic V; Benavides J; Vige X; Carter C; Taupin V; Sanofi-Synthelabo, CNS Research Department, Bagneux, France.; Among the chemokine family, fractalkine shows unusual properties: it exists as a membrane-bound and soluble protein, and both fractalkine and its receptor CX(3)CR1 are expressed predominantly in the central nervous system. In rat cell culture models, the chemokine fractalkine was expressed in neurons and microglia, bu
Questioning bioethics. AIDS, sexual ethics, and the duty to warn [see comments]: Hastings Cent Rep. 1999 Sep-Oct;29(5):26-35. Unique Identifier : AIDSLINE MED/20055120; Ainslie DC; Bioethicists have virtually assumed that Tarasoff generated a duty to warn the sexual partners of an HIV-positive man that they risked infection. Yet given the views of sex and of AIDS that have evolved in the gay community, in many cases the parallels to Tarasoff do not hold. Bioethicists should at the least attend t
Differential activation of CC chemokine receptors by AOP-RANTES.: J Biol Chem. 2000 Mar 17;275(11):7787-94. Unique Identifier : AIDSLINE MED/20179879; Elsner J; Mack M; Bruhl H; Dulkys Y; Kimmig D; Simmons G; Clapham PR; Schlondorff D; Kapp A; Wells TN; Proudfoot AE; Department of Dermatology and Allergology, Hannover Medical; University, 30449 Hannover, Germany.; RANTES (regulated on activation normal T cell expressed) has been found at elevated levels in biological fluids from patients with a wide range of allergic and autoimmune diseases and is able to attract several subtypes of leukocytes including eosinophils and monocytes into inflamed tissue. Amino-terminal modification
Management of the asymptomatic HIV-infected patient: an update.: Hosp Pract (Off Ed). 2000 Mar 15;35(3):89-92, 97-8, 101. Unique Identifier : AIDSLINE MED/20199503; Garofalo R; Makadon HJ; Harvard Medical School, Harvard University, JRI/Sidney Borum Jr.; Health Center, Boston, USA.; Guidelines for initiating antiretroviral therapy in asymptomatic patients continue to be debated. Physicians and patients should decide whether drug treatment is advisable after jointly considering psychosocial issues as well as measurements of immune function and HIV burden. Other components of care include appropria
Trimethoprim-sulfamethoxazole-graded challenge in HIV-infected patients: long-term follow-up regarding efficacy and safety.: J Allergy Clin Immunol. 2000 Mar;105(3):588-9. Unique Identifier : AIDSLINE MED/20185617; Demoly P; Messaad D; Reynes J; Faucherre V; Bousquet J; Maladies Respiratoires, INSERM U454, Hopital Arnaud de; Villeneuve, CHU de Montpellier, Montpellier, Cedex, France.
Hepatitis C virus in lymphoid cells of patients coinfected with human immunodeficiency virus type 1: evidence of active replication in monocytes/macrophages and lymphocytes.: J Infect Dis. 2000 Feb;181(2):442-8. Unique Identifier : AIDSLINE MED/20134566; Laskus T; Radkowski M; Piasek A; Nowicki M; Horban A; Cianciara J; Rakela J; Division of Transplantation Medicine, Mayo Clinic, Scottsdale, AZ; 85259, USA. laskus.tomasz@mayo.edu; It has been reported that hepatitis C virus (HCV) may be lymphotropic in the setting of human immunodeficiency virus type 1 (HIV-1) coinfection. The present study was undertaken to determine the phenotype of lymphoid cells harboring replicating HCV in HIV-1-positive subjects. By means of highly strand-specific thermos
Human immunodeficiency virus (HIV) subtype surveillance of African-born persons at risk for group O and group N HIV infections in the United States.: J Infect Dis. 2000 Feb;181(2):463-9. Unique Identifier : AIDSLINE MED/20134569; Sullivan PS; Do AN; Ellenberger D; Pau CP; Paul S; Robbins K; Kalish M; Storck C; Schable CA; Wise H; Tetteh C; Jones JL; McFarland J; Yang C; Lal RB; Ward JW; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA. pss0@cdc.gov; A population-based surveillance registry was used to identify human immunodeficiency virus (HIV)-infected persons in the United States at increased risk for group O and group N infections (those born in or near African countries where group O infection has been reported). Of 155 eligib
Presence of human immunodeficiency virus (HIV) type 1, group M, non-B subtypes, Bronx, New York: a sentinel site for monitoring HIV genetic diversity in the United States.: J Infect Dis. 2000 Feb;181(2):470-5. Unique Identifier : AIDSLINE +; Weidle PJ; Ganea CE; Irwin KL; Pieniazek D; McGowan JP; Olivo N; Ramos A; Schable C; Lal RB; Holmberg SD; Ernst JA; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, and Epidemic Intelligence Service,; Epidemiology Program Office, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA. pew6@cdc.gov; In the United States , human immunodeficiency virus (HIV) type 1, group M, subtype B is the predominant subtype. A cross-sectional study of HIV-infected patients at the Bronx- Lebanon Hospital Center,
Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines.: J Infect Dis. 2000 Feb;181(2):476-83. Unique Identifier : AIDSLINE MED/20134571; Boyer JD; Cohen AD; Vogt S; Schumann K; Nath B; Ahn L; Lacy K; Bagarazzi ML; Higgins TJ; Baine Y; Ciccarelli RB; Ginsberg RS; MacGregor RR; Weiner DB; Department of Pathology, University of Pennsylvania School of; Medicine, Philadelphia, PA 19104, USA.; There is a pressing need to test novel vaccine concepts in an effort to develop an effective vaccine for human immunodeficiency virus (HIV) type 1. A phase I clinical study was done to test the immunogenicity of an HIV env/rev DNA vaccine, which was administered intramuscularly to HIV-1-seronegative persons. Subjects
Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin.: J Infect Dis. 2000 Feb;181(2):484-90. Unique Identifier : AIDSLINE MED/20134572; Georgiou NA; van der Bruggen T; Oudshoorn M; Nottet HS; Marx JJ; van Asbeck BS; Department of Internal Medicine, University Medical Center; Utrecht, Utrecht, The Netherlands. n.georgiou@lab.azu.nl; Replication of human immunodeficiency virus type 1 (HIV-1) can be influenced by iron. Hence, decreasing the availability of iron may inhibit HIV-1 replication. Deferoxamine and deferiprone, both forming catalytically inactive iron-chelator complexes, and bleomycin, by use of which iron catalyzes oxidative nucleic acid
Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team.: J Infect Dis. 2000 Feb;181(2):491-7. Unique Identifier : AIDSLINE +; Kuritzkes DR; Sevin A; Young B; Bakhtiari M; Wu H; St Clair M; Connick E; Landay A; Spritzler J; Kessler H; Lederman MM; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver, CO 80262, USA.; daniel.kuritzkes@UCHSC.edu; The effect of baseline drug resistance mutations on response to zidovudine, lamivudine, and ritonavir was evaluated in zidovudine-experienced persons infected with human immunodeficiency virus type 1 (HIV-1). Presence of the K70R mutation was associat
Oral transmission of human immunodeficiency virus by infected seminal fluid and milk: a novel mechanism.: J Infect Dis. 2000 Feb;181(2):498-504. Unique Identifier : AIDSLINE MED/20134574; Baron S; Poast J; Richardson CJ; Nguyen D; Cloyd M; Department of Microbiology, University of Texas Medical Branch,; Galveston, TX 77555-1019, USA. sabaron@utmb.edu; Salivary transmission by the 30 million human immunodeficiency virus (HIV) carriers is rare, despite kissing, aerosolization, and dental treatment. The main protective mechanism of saliva is reported to be inactivation of HIV-transmitting leukocytes by its unique hypotonicity; however, the successful oral transmission
RANTES production by T cells and CD8-mediated inhibition of human immunodeficiency virus gene expression before initiation of potent antiretroviral therapy predict sustained suppression of viral replication.: J Infect Dis. 2000 Feb;181(2):505-12. Unique Identifier : AIDSLINE MED/20134575; Fransen S; Copeland KF; Smieja M; Smaill F; Rosenthal KL; Department of Pathology, McMaster University Health Sciences; Centre, Hamilton, Ontario, Canada.; A prospective blinded study was conducted to determine whether immunological differences exist between patients receiving potent antiretroviral therapy who are able to achieve and maintain an undetectable virus load (
Unexpected coreceptor usage of primary human immunodeficiency virus type 1 isolates from viremic patients under highly active antiretroviral therapy.: J Infect Dis. 2000 Feb;181(2):513-21. Unique Identifier : AIDSLINE MED/20134576; Holtkamp N; Otteken A; Findhammer S; Miller V; Kurth R; Werner A; Paul-Ehrlich-Institut, Langen, Germany.; Recently, combinations of antiretroviral drugs (highly active antiretroviral therapy [HAART]) have led to a dramatic reduction of human immunodeficiency virus type 1 (HIV-1)-related clinical symptoms. Success of treatment is defined as almost complete suppression of plasma viremia, although in a sizable fraction of pa
Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy.: J Infect Dis. 2000 Feb;181(2):522-31. Unique Identifier : AIDSLINE MED/20134577; Gunthard HF; Wong JK; Spina CA; Ignacio C; Kwok S; Christopherson C; Hwang J; Haubrich R; Havlir D; Richman DD; Department of Pathology, University of California San Diego,; School of Medicine, La Jolla, California, USA.; huldrych.guenthard@dim.usz.ch; Nineteen patients infected with human immunodeficiency virus (HIV) with varying levels of viral suppression achieved with antiretroviral therapy were evaluated to determine whether trivalent influenza vaccine activated HIV replication. Humoral immune responses and CD4+ lymphocyte subsets were compared in 5 HIV-uninfec
Secretory anti-human immunodeficiency virus (HIV) antibodies in colostrum and breast milk are not a major determinant of the protection of early postnatal transmission of HIV.: J Infect Dis. 2000 Feb;181(2):532-9. Unique Identifier : AIDSLINE MED/20134578; Becquart P; Hocini H; Levy M; Sepou A; Kazatchkine MD; Belec L; Institut National de la Sante et de la Recherche Medicale U430,; Hopital Broussais, Paris, France.; pierre.becquart@brs.ap-hop-paris.fr; The immune response to human immunodeficiency virus (HIV) type 1 was evaluated in breast milk from HIV-infected African mothers who had transmitted and those who had not transmitted HIV to their children through breast-feeding. The levels, specific activities against gp160 and 2 HIV-derived peptides from gp41 and gp12
A randomized study of the safety and antiretroviral activity of hydroxyurea combined with didanosine in persons infected with human immunodeficiency virus type 1. American Foundation for AIDS Research Community-Based Clinical Trials Network.: Unique Identifier : AIDSLINE MED/20134579 P; Hellinger JA; Iwane MK; Smith JJ; Fleishman AN; Torres RA; Schrader S; Perez G; Cohen CJ
Use of human immunodeficiency virus (HIV) human hyperimmune immunoglobulin in HIV type 1-infected children (Pediatric AIDS clinical trials group protocol 273).: J Infect Dis. 2000 Feb;181(2):548-54. Unique Identifier : AIDSLINE MED/20134580; Stiehm ER; Fletcher CV; Mofenson LM; Palumbo PE; Kang M; Fenton T; Sapan CV; Meyer WA; Shearer WT; Hawkins E; Fowler MG; Bouquin P; Purdue L; Sloand EM; Nemo GJ; Wara D; Bryson YJ; Starr SE; Petru A; Burchett S; UCLA Children's Hospital, Los Angeles, CA 90095, USA.; estiehm@mednet. ucla.edu; The clinical, immunologic, and virologic effects and the pharmacokinetics of human immunodeficiency virus (HIV) human hyperimmune immunoglobulin (HIVIG) were assessed in 30 HIV-infected children aged 2-11 years. All had moderately advanced disease with an immune complex-dissociated (ICD) p24 antigen >70 pg/mL and were
Genital tract human immunodeficiency virus type 1 (HIV-1) shedding and inflammation and HIV-1 env diversity in perinatal HIV-1 transmission.: J Infect Dis. 2000 Feb;181(2):555-63. Unique Identifier : AIDSLINE MED/20134581; Panther LA; Tucker L; Xu C; Tuomala RE; Mullins JI; Anderson DJ; Department of Obstetrics, Brigham and Women's Hospital, Harvard; Medical School, Boston, Massachusetts, USA.; This study sought to identify genital tract characteristics associated with vertical transmission of human immunodeficiency virus type 1 (HIV-1). HIV-1 DNA and RNA, HIV-1 env diversity, and inflammatory cells were quantified in cervicovaginal lavages (CVLs) of 24 women enrolled in the Women and Infants Transmission St
T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats.: J Infect Dis. 2000 Feb;181(2):564-75. Unique Identifier : AIDSLINE MED/20134582; Liang Y; Hudson LC; Levy JK; Ritchey JW; Tompkins WA; Tompkins MB; Department of Microbiology, College of Veterinary Medicine, North; Carolina State University, Raleigh, NC 27606, USA.; Similar to human immunodeficiency virus type 1, feline immunodeficiency virus (FIV) replicates in the thymus of infected animals, causing marked alteration in thymic lymphocyte subpopulations. The immune phenotype and cytokine patterns in the thymus and secondary lymphoid tissues of FIV-infected cats were investigated
Exogenous glucocorticoids alter parameters of early feline immunodeficiency virus infection.: J Infect Dis. 2000 Feb;181(2):576-86. Unique Identifier : AIDSLINE MED/20134583; Barr MC; Huitron-Resendiz S; Selway DR; Henriksen SJ; Phillips TR; Immune Complex Corporation, San Diego, CA 92129, USA.; mbarr@immunecomplex.com; Feline immunodeficiency virus (FIV), a lentivirus, causes progressive immunosuppression and neurologic dysfunction in cats. Glucocorticoids are common therapeutic agents that are also immunosuppressive, and their use might enhance the pathogenic effects of lentivirus infections. Methylprednisolone acetate, a long-acti
Intravaginal practices, vaginal flora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women.: J Infect Dis. 2000 Feb;181(2):587-94. Unique Identifier : AIDSLINE MED/20134584; van De Wijgert JH; Mason PR; Gwanzura L; Mbizvo MT; Chirenje ZM; Iliff V; Shiboski S; Padian NS; The Population Council, New York, NY 10017, USA.; jvandewijgert@popcouncil.org; One hundred sixty-nine Zimbabwean women were studied to determine whether the use of intravaginal practices (cleaning with the fingers, wiping the vagina, and inserting traditional substances) are associated with disturbances of vaginal flora and acquisition of sexually transmitted diseases (STDs). Subjects were inter
Host immune reactivity determines the efficacy of combination immunotherapy and antifungal chemotherapy in candidiasis.: J Infect Dis. 2000 Feb;181(2):686-94. Unique Identifier : AIDSLINE MED/20134598; Mencacci A; Cenci E; Bacci A; Bistoni F; Romani L; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, 06122 Perugia,; Italy.; In immunocompetent mice with candidiasis, successful therapy with amphotericin B and fluconazole relies on the induction of protective, T helper (Th) type 1 responses, an effect potentiated by concomitant interleukin (IL)-4 neutralization. To assess the therapeutic efficacy of combined treatments with antifungals and
Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion.: J Infect Dis. 2000 Feb;181(2):701-9. Unique Identifier : AIDSLINE MED/20134600; White AC; Robinson P; Okhuysen PC; Lewis DE; Shahab I; Lahoti S; DuPont HL; Chappell CL; Infectious Diseases Section, Dept. of Medicine, Baylor College of; Medicine, Houston, TX 77030. arthurw@bcm.tmc.edu; To investigate the role of interferon (IFN)-gamma in human cryptosporidiosis, jejunal biopsies from experimentally infected volunteers and chronically infected AIDS patients were examined for IFN-gamma expression by in situ hybridization. IFN-gamma expression was compared with oocyst excretion, baseline serum anti-Cry
Selection of multiresistant hepatitis B virus during sequential nucleoside-analogue therapy.: J Infect Dis. 2000 Feb;181(2):713-6. Unique Identifier : AIDSLINE MED/20134602; Mutimer D; Pillay D; Cook P; Ratcliffe D; O'Donnell K; Dowling D; Shaw J; Elias E; Cane PA; Public Health Laboratory Service Antiviral Susceptibility; Reference Unit, Divisions of Medical Sciences, University of; Birmingham Medical School, Edgbaston, Birmingham, United Kingdom.; Hepatitis B virus (HBV) drug resistance to lamivudine is always accompanied by mutations in the viral polymerase gene at position 550, termed group 1 (M550V with L526M) or group 2 (M550I) mutations. The latter mutation has not been associated with famciclovir resistance. Thus, the addition of famciclovir to lamivudine
Cytomegalovirus (CMV) DNA load predicts relapsing CMV infection after solid organ transplantation.: J Infect Dis. 2000 Feb;181(2):717-20. Unique Identifier : AIDSLINE MED/20134603; Sia IG; Wilson JA; Groettum CM; Espy MJ; Smith TF; Paya CV; Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USA.; Cytomegalovirus ( CMV ) DNA load was analyzed as a marker for relapse of CMV infection in 24 solid organ transplant patients with CMV infection or disease who received a fixed 14-day course of intravenous ganciclovir. Viral load was measured in blood samples obtai
Uninfected and cytomegalic endothelial cells in blood during cytomegalovirus infection: effect of acute rejection.: J Infect Dis. 2000 Feb;181(2):721-4. Unique Identifier : AIDSLINE MED/20134604; Kas-Deelen AM; de Maar EF; Harmsen MC; Driessen C; van Son WJ; The TH; Department of Clinical Immunology, University Hospital Groningen,; 9713 GZ Groningen, The Netherlands. A.M.Deelen@med.rug.nl; After transplantation, human cytomegalovirus (HCMV) infections can cause vascular damage to both the graft and the host. To study a possible relationship between the degree of vascular injury, clinical symptoms of HCMV infection, and transplant rejection, the appearance and numbers
Comparison of the safety, vaccine virus shedding, and immunogenicity of influenza virus vaccine, trivalent, types A and B, live cold-adapted, administered to human immunodeficiency virus (HIV)-infected and non-HIV-infected adults.: J Infect Dis. 2000 Feb;181(2):725-8. Unique Identifier : AIDSLINE MED/20134605; King JC Jr; Treanor J; Fast PE; Wolff M; Yan L; Iacuzio D; Readmond B; O'Brien D; Mallon K; Highsmith WE; Lambert JS; Belshe RB; Center for Vaccine Development, University of Maryland School of; Medicine, Baltimore, MD 21201, USA. jking@som.umaryland.edu; Fifty-seven human immunodeficiency virus (HIV)-infected (CDC class A1-2) and 54 non-HIV-infected adults, not prescreened for influenza susceptibility, were randomized to receive trivalent live attenuated influenza vaccine (LAIV) or placebo intranasally. LAIV was safe and well tolerated with no serious adverse events a
Human immunodeficiency virus-infected persons with mutations conferring resistance to zidovudine show reduced virologic responses to hydroxyurea and stavudine-lamivudine.: Unique Identifier : AIDSLINE MED/20134606; Montaner JS; Mo T; Raboud JM; Rae S; Alexander CS; Zala C; Rouleau D; Harrigan PR; BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital,; Vancouver, BC, Canada V6Z 1Y6.; The baseline predictors of poor virologic response (
Effect of interleukin (IL)-15 priming on IL-12 and interferon-gamma production by pathogen-stimulated peripheral blood mononuclear cells from human immunodeficiency virus-seropositive and -seronegative donors.: J Infect Dis. 2000 Feb;181(2):733-6. Unique Identifier : AIDSLINE MED/20134607; Parayath KE; Harrison TS; Levitz SM; Evans Memorial Department of Clinical Research and Department of; Medicine, Boston University School of Medicine, Boston, MA; 02118-2393, USA.; Hypoproduction of the cytokines interleukin (IL)-12 and interferon (IFN)-gamma is thought to contribute to the impaired immunity seen in human immunodeficiency virus (HIV)-infected persons. The effects of priming with IL-15 on the production of IL-12 and IFN-gamma by stimulated peripheral blood mononuclear cells (PBMC
Secretor polymorphism and human immunodeficiency virus infection in Senegalese women.: J Infect Dis. 2000 Feb;181(2):737-9. Unique Identifier : AIDSLINE MED/20134608; Ali S; Niang MA; N'doye I; Critchlow CW; Hawes SE; Hill AV; Kiviat NB; Wellcome Trust Centre for Human Genetics, University of Oxford,; Oxford, United Kingdom.; The FUT2 gene encodes the enzyme alpha (1,2) fucosyltransferase, which determines expression of blood-group antigens on mucosal epithelial cell surfaces and in secretions. Homozygotes for a specific stop mutation in FUT2 (nonsecretors) cannot produce this enzyme and thus are unable to express blood group antigens. Non
Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples.: J Infect Dis. 2000 Feb;181(2):740-5. Unique Identifier : AIDSLINE +; Venturi G; Catucci M; Romano L; Corsi P; Leoncini F; Valensin PE; Zazzi M; Sezione di Microbiologia, Dipartimento di Biologia Molecolare,; Universita di Siena, Italy.; Twenty-four adults infected with human immunodeficiency virus type 1 (HIV-1) with central nervous system symptoms were studied for antiretroviral resistance mutations in HIV-1 RNA obtained from paired cerebrospinal fluid (CSF) and plasma samples. Paired sequences were obtained from 21 and 13 patients for reverse trans
Effect of human immunodeficiency virus (HIV) type 1 viral genotype on mother-to-child transmission of HIV-1.: J Infect Dis. 2000 Feb;181(2):746-9. Unique Identifier : AIDSLINE MED/20134610; Murray MC; Embree JE; Ramdahin SG; Anzala AO; Njenga S; Plummer FA; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.; The objective of this study was to determine whether the maternal infecting human immunodeficiency virus (HIV) type 1 clade affects mother-to-child transmission frequency. Mothers in the mother-to-child HIV-1 transmission study in Nairobi, Kenya , were grouped by HIV-1 status of thei
Stimulation of macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES by Candida albicans and Cryptococcus neoformans in peripheral blood mononuclear cells from persons with and without human immunodeficiency virus infection.: J Infect Dis. 2000 Feb;181(2):791-4. Unique Identifier : AIDSLINE MED/20134621; Huang C; Levitz SM; Evans Memorial Department of Clinical Research, Boston University; School of Medicine, Boston, MA, USA.; The beta-chemokine macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES are critical for recruitment of inflammatory cells into infected tissue. Moreover, by binding to the human immunodeficiency virus (HIV) coreceptor CCR5, release of these chemokines could influence the course of HIV infection. beta-c
Mastitis and human immunodeficiency virus transmission: chemokines and maternal monocytes [letter]: J Infect Dis. 2000 Feb;181(2):800-1. Unique Identifier : AIDSLINE MED/20134623; Michie CA; Lynn W
Neglected opportunities [letter]: J Infect Dis. 2000 Feb;181(2):804-5. Unique Identifier : AIDSLINE MED/20134628; Moench TR
Oropharyngeal Candida colonization and human immunodeficiency virus type 1 infection [letter]: J Infect Dis. 2000 Feb;181(2):812-3. Unique Identifier : AIDSLINE MED/20134635; Klein RS; Arnsten JH; Sobel JD
Case presentation: Undertreatment of pain: a risk associated with neuromuscular blockade in the intensive care unit [see comments]: J Pain Symptom Manage. 2000 Feb;19(2):154. Unique Identifier : AIDSLINE MED/20164773; Pigazzi A; Manfredi PL; Department of Surgery, New York Presbyterian Hospital-Cornell; Campus, New York, NY, USA.
Kaposi's sarcoma of the pancreas mimicking pancreatic cancer in an HIV-infected patient. Clinical diagnosis by detection of HHV 8 in bile and complete remission following antiviral and cytostatic therapy with paclitaxel.: Int J Pancreatol. 1999 Dec;26(3):193-9. Unique Identifier : AIDSLINE MED/20196846; Menges M; Pees HW; Department of Internal Medicine II, University Hospital of the; Saarland, Homburg, Germany.; BACKGROUND: Diagnosis of pancreatic cancer is usually made by endoscopic retrograde cholangiopancreatography (ERCP) and corresponding findings in computed tomography (CT) or magnetic resonance imaging. Kaposi s sarcoma, a frequent tumor in individuals with a late-stage HIV infection, can be located in the gastrointest
A molecular-field-based similarity study of non-nucleoside HIV-1 reverse transcriptase inhibitors. 2. The relationship between alignment solutions obtained from conformationally rigid and flexible matching.: J Comput Aided Mol Des. 2000 Jan;14(1):39-51. Unique Identifier : AIDSLINE MED/20167569; Mestres J; Rohrer DC; Maggiora GM; Pharmacia & Upjohn Inc., Kalamazoo, MI 49001, USA.; An analysis of the relationship among alignment solutions obtained from field-based matching of a representative set of rigid conformers of three non-nucleoside HIV-1 reverse transcriptase inhibitors and solutions obtained from flexible matching of the same conformers is presented. In some cases, different alignment s
The role of probiotic cultures in the control of gastrointestinal health.: J Nutr. 2000 Feb;130(2S Suppl):396S-402S. Unique Identifier : AIDSLINE MED/20184989; Rolfe RD; Department of Microbiology and Immunology, Texas Tech University; Health Sciences Center, Lubbock 79430, USA.; The use of probiotics to enhance intestinal health has been proposed for many years. Probiotics are traditionally defined as viable microorganisms that have a beneficial effect in the prevention and treatment of specific pathologic conditions when they are ingested. There is a relatively large volume of literature tha
Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.: J Med Chem. 2000 Mar 9;43(5):1034-40. Unique Identifier : AIDSLINE MED/20181857; Genin MJ; Biles C; Keiser BJ; Poppe SM; Swaney SM; Tarpley WG; Yagi Y; Romero DL; Combinatorial and Medicinal Chemistry Research, Infectious; Diseases Research, Discovery Technologies, Pharmacia & Upjohn,; Inc., Kalamazoo, Michigan 49001, USA. michael.j.genin@am.pnu.com; Through computationally directed broad screening, a novel 1, 5-diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type (IC(50) = 2.3 microM) and delavirdine-resistant P236L (IC(50) = 1.1 m
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.: J Med Chem. 2000 Mar 9;43(5):778-83. Unique Identifier : AIDSLINE MED/20181836; Witvrouw M; Weigold H; Pannecouque C; Schols D; De Clercq E; Holan G; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, B-3000 Leuven, Belgium, USA.; Myriam.Witvrouw@uz.kukleuven.ac.be; A series of polyoxometalates have been synthesized and evaluated for their inhibitory effects on HIV-1(III(B)) and HIV-1(ROD) replication in MT-4 cells. All compounds showed activity against HIV-1 and HIV-2, but the antiviral potency of the heteropolytungstates varied considerably depending on their chemical structure
5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.: J Med Chem. 2000 Mar 9;43(5):843-58. Unique Identifier : AIDSLINE MED/20181842; Boyer FE; Vara Prasad JV; Domagala JM; Ellsworth EL; Gajda C; Hagen SE; Markoski LJ; Tait BD; Lunney EA; Palovsky A; Ferguson D; Graham N; Holler T; Hupe D; Nouhan C; Tummino PJ; Urumov A; Zeikus E; Zeikus G; Gracheck SJ; Sanders JM; VanderRoest S; Brodfuehrer J; Iyer K; Sinz M; Gulnik SV; Department of Chemistry, Parke-Davis Pharmaceutical Research,; Division of Warner-Lambert Company, 2800 Plymouth Road, Ann; Arbor, Michigan 48105, USA.; On the basis of previous SAR findings and molecular modeling studies, a series of compounds were synthesized which possessed various sulfonyl moieties substituted at the 4-position of the C-3 phenyl ring substituent of the dihydropyran-2-one ring system. The sulfonyl substituents were added in an attempt to fill the a
2',6'-Dimethylphenoxyacetyl: a new achiral high affinity P(3)-P(2) ligand for peptidomimetic-based HIV protease inhibitors.: Unique Identifier : AIDSLINE MED/20202350; Beaulieu PL; Anderson PC; Cameron DR; Croteau G; Gorys V; Grand-Maitre C; Lamarre D; Liard F; Paris W; Plamondon L; Soucy F; Thibeault D; Wernic D; Yoakim C; Pav S; Tong L; Boehringer Ingelheim Pharmaceuticals Inc., 175 Briar Ridge Road,; Ridgefield, Connecticut 06877, USA.; pbeaulieu@lav.boehringer-ingelheim.com; Starting from palinavir (1), our lead HIV protease inhibitor, we have discovered a new series of truncated analogues in which the P(3)-P(2) quinaldic-valine portion of 1 was replaced by 2 , 6 -dimethylphenoxyacetyl. With EC(50) s in the 1-2 nM range, some of these compounds are among the most potent inhibitors of HIV
Markedly increased plasma (1-->3)-beta-D-glucan is a diagnostic and therapeutic indicator of Pneumocystis carinii pneumonia in a non-AIDS patient [letter]: J Med Microbiol. 2000 Apr;49(4):393-4. Unique Identifier : AIDSLINE MED/20216415; Teramoto S; Sawaki D; Okada S; Ouchi Y
From the Food and Drug Administration.: JAMA. 2000 Apr 5;283(13):1679. Unique Identifier : AIDSLINE MED/20216257
Epstein-Barr virus infection to Epstein-Barr virus-negative nasopharyngeal carcinoma cell line TW03 enhances its tumorigenicity.: Lab Invest. 2000 Mar;80(3):303-12. Unique Identifier : AIDSLINE MED/20205933; Teramoto N; Maeda A; Kobayashi K; Hayashi K; Oka T; Takahashi K; Takada K; Klein G; Akagi T; Department of Pathology, Okayama University Medical School,; Japan. terra@med.okayama-u.ac.jp; Almost all nasopharyngeal carcinomas (NPCs) are infected by Epstein-Barr virus (EBV), but most ex vivo NPC cells lose EBV genomes during passages. In this study, an EBV-negative NPC cell line, TW03, established from EBV-carrying NPC was reinfected with EBV by cocultivation with irradiated Akata cells carrying recombin
Important role of thiol compounds to protect oxidative stress on HTLV-I(+) T lymphocytes [letter]: Leuk Res. 2000 Mar;24(3):265-6. Unique Identifier : AIDSLINE MED/20201589; Miyatake JI; Maeda Y; Nawata H; Naiki Y; Sumimoto Y; Matsuda M; Kanamaru A
[The homeless have right to health and social care. Special outpatient clinics are badly needed]: Lakartidningen. 2000 Mar 1;97(9):932-5. Unique Identifier : AIDSLINE MED/20205212; Halldin J; Karolinska sjukhuset, Stockholm.
High-dose therapy and autologous haematopoietic stem-cell transplantation for HIV-1-associated lymphoma [letter]: Lancet. 2000 Mar 25;355(9209):1071-2. Unique Identifier : AIDSLINE MED/20205962; Gabarre J; Azar N; Autran B; Katlama C; Leblond V; We describe the results of autologous haematopoietic stem-cell transplantation in eight patients with HIV-1-associated lymphoma. Collection and grafting of stem cells is feasible and this treatment seems appropriate in chemotherapy-sensitive HIV-1-associated lymphoma.
Toxicity of nucleoside-analogue reverse-transcriptase inhibitors [letter]: Lancet. 2000 Mar 25;355(9209):1096. Unique Identifier : AIDSLINE MED/20205977; Walker UA; Setzer B; Volksbeck SI
A study of graft versus host disease using bile duct implants under the kidney capsule.: Liver. 2000 Feb;20(1):16-26. Unique Identifier : AIDSLINE MED/20189491; Hardy CL; Morahan G; Bhathal PS; Department of Pathology, The University of Melbourne, Parkville,; Victoria, Australia.; BACKGROUND/AIMS: Graft versus host disease (GVHD) following histoincompatible bone marrow transplantation may be modelled experimentally using irradiated metallothionein promoter-H-2Kb transgenic mice (MET-Kb mice), reconstituted with syngeneic non-transgenic spleen and lymph node (LN) cells. In this model, inflammati
The epidemic of asthma: too much allergen or not enough infection?: Med J Aust. 2000 Feb 7;172(3):119-21. Unique Identifier : AIDSLINE MED/20199197; Abramson MJ; Walters EH; Department of Epidemiology and Preventive Medicine, Monash; Medical School, Alfred Hospital, Prahran, Vic.; Michael.Abramson@med.monash.edu.au; Asthma has generally been thought to result from exposure to allergens in infancy leading to atopy, and eventually to airway hyperresponsiveness. There is now evidence that implicates absence of childhood infections as a factor in development of asthma. Childhood infections seem to be important in normal maturation of
Inhibition of M-tropic HIV-1 infection by the fd phage-gene 3 protein with MIP-1alpha-binding activity.: Mol Immunol. 1999 Dec;36(18):1249-54. Unique Identifier : AIDSLINE MED/20150239; Meta A; Torigoe N; Ito Y; Arakaki R; Nakashima H; Sugimura K; Department of Bioengineering, Faculty of Engineering, Kagoshima; University, 1-21-40 Korimoto, Kagoshima, Japan.; CCR5 is a chemokine receptor with seven transmembrane-domains. It is expressed on T cells and macrophages and functions as the principal co-receptor for macrophage (M)-tropic strains of HIV-1. The anti-CCR5 monoclonal antibody (mAb) 2D7 inhibits the binding and chemotaxis of the three natural beta-chemokine ligands of
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy [see comments]: N Engl J Med. 2000 Apr 13;342(15):1077-84. Unique Identifier : AIDSLINE MED/20205681; Felker GM; Thompson RE; Hare JM; Hruban RH; Clemetson DE; Howard DL; Baughman KL; Kasper EK; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD, USA.; BACKGROUND: Previous studies of the prognosis of patients with heart failure due to cardiomyopathy categorized patients according to whether they had ischemic or nonischemic disease. The prognostic value of identifying more specific underlying causes of cardiomyopathy is unknown. METHODS: We evaluated the outcomes of
Discontinuation of prophylaxis for Mycobacterium avium complex: Unique Identifier : AIDSLINE MED/20205682 P
Are AIDS dissidents advising South Africa? [news]: Nature. 2000 Mar 16;404(6775):216. Unique Identifier : AIDSLINE MED/20210736; Cherry M
Could AIDS treatments slip through patents loophole? [news]: Nature. 2000 Mar 23;404(6776):322. Unique Identifier : AIDSLINE MED/20208481; Smaglik P
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1.: Nature. 2000 Mar 23;404(6776):407-11. Unique Identifier : AIDSLINE MED/20208519; Gu L; Tseng S; Horner RM; Tam C; Loda M; Rollins BJ; Department of Adult Oncology, Dana-Farber Cancer Institute,; Brigham & Women's Hospital, and Harvard Medical School, Boston,; Massachusetts 02115, USA.; Activated T lymphocytes differentiate into effector cells tailored to meet disparate challenges to host integrity. For example, type 1 and type 2 helper (T(H)1 and T(H)2) cells secrete cytokines that enhance cell-mediated and humoral immunity, respectively. The chemokine monocyte chemoattractant protein-1 (MCP-1) can
The impact of HIV infection on primary headache. Unexpected findings from retrospective, cross-sectional, and prospective analyses.: Pain. 2000 Mar;85(1-2):191-200. Unique Identifier : AIDSLINE MED/20159105; Evers S; Wibbeke B; Reichelt D; Suhr B; Brilla R; Husstedt I; Department of Neurology, University of Munster,; Albert-Schweitzer-Strasse 33, D-48129, Munster, Germany.; everss@uni-muenster.de; Headache is one of the most important factors influencing the quality of life in patients infected with the human immunodeficiency virus type 1 (HIV). However, only symptomatic headache but not changes or primary headache types during HIV infection have been studied to date. Therefore, we aimed to determine the impact
T-cell activity in HLA-associated autoimmune diseases.: Panminerva Med. 1999 Dec;41(4):315-7. Unique Identifier : AIDSLINE MED/20169890; Puglisi F; Capuano P; Simone M; Verzillo F; Laurentaci C; Faculty of Medicine and Surgery, University of Bari, Italy.; BACKGROUND: The existence of T-helper-1 (Th1) and T-helper-2 (Th2) subsets has been implicated in the regulation of several immune responses, and alterations in the Th1/Th2 balance have been involved in autoimmunity. The present study investigates the relative influence of Th1 and Th2 patterns in autoimmune responses
Forcing a mother with HIV to have her baby tested for the virus is not necessarily in the child's best interest.: Nurs Times. 1999 Oct 6-12;95(40):19. Unique Identifier : AIDSLINE MED/20209920; Hehir B
[The level of triglycerides, total cholesterol and HDL cholesterol in various stages of human immunodeficiency virus (HIV) infection]: Pol Arch Med Wewn. 1999 Feb;101(2):145-50. Unique Identifier : AIDSLINE MED/20188196; Rogowska-Szadkowska D; Borzuchowska A; Klinika Obserwacyjno-Zakazna AM w Bialymstoku.; In 63 HIV-infected individuals the levels of concentration plasma triglicerides, total cholesterol and HDL cholesterol were determined by the level of immunological deficiency defined according to the CD4 lymphocytes count. The analyzed markers of lipid disorder allow to draw the following conclusions: 1. Along with t
The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo.: Placenta. 2000 Jan;21(1):73-8. Unique Identifier : AIDSLINE MED/20159131; Lin L; Xu B; Rote NS; Department of Microbiology and Immunology, Wright State; University School of Medicine, Dayton, Ohio, 45435, USA.; The env region of the human endogenous retrovirus ERV-3 is expressed during differentiation of trophoblast and the choriocarcinoma BeWo. Stable transfectants with ERV-3 env exhibit most aspects of trophoblast differentiation, including inhibition of cell proliferation, changes in cell morphology, and increased product
[Coinfection with HIV and HTLV-I infection and survival in AIDS stage. French Guiana Study. GECVIG (Clinical HIV Study Group in Guiana)]: Presse Med. 2000 Mar 4;29(8):413-6. Unique Identifier : AIDSLINE MED/20202988; Sobesky M; Couppie P; Pradinaud R; Godard MC; Alvarez F; Benoit B; Carme B; Lebeux P; Centre d'Information et de Soins de l'Immunodeficience humaine,; CHG de Cayenne. sobeskym@nplus.gf; OBJECTIVE: The purpose of this study was to investigate the effect of HTLVI infection on survival in AIDS patients in French Guiana . PATIENTS AND METHODS: A cohort of 151 adult patients with AIDS were followed from January 1992 thro
[Agranulocytosis in acute hepatitis B in an HIV seropositive patient]: Presse Med. 2000 Mar 4;29(8):417-8. Unique Identifier : AIDSLINE MED/20202989; Brazille P; Coutant-Perronne V; Malkin JE; Raguin G; Service de Medecine interne, Hopital Croix-Saint-Simon, Paris.; pbrazille@europost.org; BACKGROUND: During the course of acute hepatitis B, hematology disorders are common though they are generally mild and occur early. Agranulocytosis is exceptional and occurs late in the disease course. CASE REPORT: We report a case of agranulocytosis which developed 3 weeks after onset of acute hepatitis B in an HIV-p
[Chief health risks associated with intravenous heroin and cocaine abuse]: Presse Med. 2000 Mar 4;29(8):453-7. Unique Identifier : AIDSLINE MED/20203002; Ben Diane MK; Feroni I; Poncet M; Obadia Y; Observatoire Regional de la Sante Provence-Alpes-Cote d'Azur,; INSERM U379, Marseille.; THREE CATEGORIES OF COMPLICATIONS: Heroine and cocaine are the main drugs used by injecting drug-users (IDU) in France . There are three categories of complications associated with intravenous drug abuse: effects related to drug toxicity, effects associated with the administration r
From the cover: engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors.: Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2208-13. Unique Identifier : AIDSLINE MED/20160930; Parker JN; Gillespie GY; Love CE; Randall S; Whitley RJ; Markert JM; Department of Pediatrics, Brain Tumor Research Laboratories,; Division of Neurosurgery, Department of Surgery, University of; Alabama, Birmingham, AL 35294-3295, USA.; Genetically engineered, neuroattenuated herpes simplex viruses (HSVs) expressing various cytokines can improve survival when used in the treatment of experimental brain tumors. These attenuated viruses have both copies of gamma(1)34.5 deleted. Recently, we demonstrated increased survival of C57BL/6 mice bearing syngen
Virus phenotype switching and disease progression in HIV-1 infection.: Proc R Soc Lond B Biol Sci. 1999 Dec 22;266(1437):2523-30. Unique Identifier : AIDSLINE MED/20155491; Callaway DS; Ribeiro RM; Nowak MA; The Wellcome Trust Centre for the Epidemiology of Infectious; Diseases, Department of Zoology, University of Oxford, UK.; One of the phenotypic distinctions between different strains of human immunodeficiency virus type 1 (HIV-1) has to do with the ability to cause target cells to form large multinucleate bodies known as syncytia. There are two phenotypes according to this characterization: syncytium-inducing (SI) and non-syncytium-induc
Factors associated with neuropsychological performance in HIV-seropositive subjects without AIDS.: Psychol Med. 2000 Jan;30(1):205-17. Unique Identifier : AIDSLINE MED/20185266; Pereda M; Ayuso-Mateos JL; Gomez Del Barrio A; Echevarria S; Farinas MC; Garcia Palomo D; Gonzalez Macias J; Vazquez-Barquero JL; Department of Medicine and Psychiatry, University of Cantabria; Medical School, Hospital Universitario Marques de Valdecilla,; Santander, Spain.; BACKGROUND: Previous research has suggested that several factors may influence the presence of cognitive impairment in human immunodeficiency virus (HIV) infection. The objective of this study was to assess the impact of cognitive reserve capacity and other variables on neuropsychological performance in early HIV infe
Epidemiology of human immunodeficiency virus infection and associated neurologic illness.: Semin Neurol. 1999;19(2):105-11. Unique Identifier : AIDSLINE MED/20181460; Lanska DJ; Veterans Affairs Medical Center, Great Lakes Health Care System,; Tomah, Wisconsin 54660, USA.; Worldwide, 30 million people are infected with the human immunodeficiency virus (HIV), with almost 6 million new infections in 1997. Recent therapeutic advances, which have altered the natural history of HIV infection, and changes in the AIDS case definition, both complicate evaluations of temporal changes in AIDS inc
Pathobiology of human immunodeficiency virus dementia.: Semin Neurol. 1999;19(2):113-27. Unique Identifier : AIDSLINE MED/20181461; Nath A; Department of Neurology, University of Kentucky, Lexington; 40536-0284, USA.; The pathobiology of dementia that accompanies infection with the human immunodeficiency virus involves complex interactions of the virus with the host. The virus enters the brain either as free viral particles or hidden in infected monocytes (the Trojan Horse mechanism). Within t
Human immunodeficiency virus-associated dementia.: Semin Neurol. 1999;19(2):129-50. Unique Identifier : AIDSLINE MED/20181462; McArthur JC; Sacktor N; Selnes O; Department of Neurology, Johns Hopkins University, Baltimore,; Maryland, USA.; HIV-associated dementia will eventually develop in 15-20% of individuals with advanced HIV disease. It has become one of the leading causes of dementia in the young, with 10,000 new cases annually in the USA. The clinical syndrome includes progressive development of psychomotor slo
Diseases of the spinal cord in human immunodeficiency virus infection.: Semin Neurol. 1999;19(2):151-5. Unique Identifier : AIDSLINE MED/20181463; Di Rocco A; Beth Israel Medical Center, Albert Einstein College of Medicine,; Department of Neurology, New York, New York, USA.; The most common disease of the spinal cord in human immunodeficiency virus (HIV) infection is vacuolar myelopathy. Pathology studies have demonstrated that vacuolization in the thoracic spinal cord is present in more than a third of patients with AIDS. The disease, however, manifests clinically only when the vacuoliza
Neuromuscular complications of the human immunodeficiency virus type 1 infection.: Semin Neurol. 1999;19(2):157-64. Unique Identifier : AIDSLINE MED/20181464; Wulff EA; Simpson DM; Department of Neurology, The Mount Sinai Medical Center, New; York, New York 10029, USA.; Neuromuscular disorders are the most frequent neurologic complications associated with human immunodeficiency virus (HIV) infection and AIDS. Although neurologic disorders are frequently overlooked, they add considerable morbidity and mortality to patients with HIV infection. It is critically important to properly dia
Clinical features and treatment interventions for human immunodeficiency virus-associated neurologic disease in children.: Semin Neurol. 1999;19(2):165-76. Unique Identifier : AIDSLINE MED/20181465; Mintz M; Department of Neurology, The Children's Hospital of Philadelphia,; Pennsylvania, USA.; HIV-1 infection in children and adolescents can cause progressive neurologic disease, affective brain growth, motor function, and neurodevelopment. In addition, myelopathies, neuropathies, myopathies, strokes, and psychiatric or behavioral manifestations can be a result of HIV-1 infection, OI, or toxicities of treatme
Bacterial and fungal brain infections in AIDS.: Semin Neurol. 1999;19(2):177-84. Unique Identifier : AIDSLINE MED/20181466; Marra CM; University of Washington, Seattle, USA.; Many bacterial and fungal pathogens can infect the central nervous system (CNS) in patients also infected with human immunodeficiency virus (HIV). Most of these organisms cause meningitis, and this is sometimes accompanied by focal parenchymal infection. More virulent pathogens, such as Mycobacterium tuberculosis homi
Opportunistic viral infections in the setting of human immunodeficiency virus.: Semin Neurol. 1999;19(2):185-92. Unique Identifier : AIDSLINE MED/20181467; Clifford DB; Washington University School of Medicine, St. Louis, Missouri,; USA.; Human immunodeficiency virus (HIV) infection has provided a setting in which additional neurologic problems develop. The mechanism of these complications varies from agent to agent, but the added spectrum of diseases encountered has challenged diagnosticians and provided unparalleled opportunities to develop a deeper
Progressive multifocal leukoencephalopathy.: Semin Neurol. 1999;19(2):193-200. Unique Identifier : AIDSLINE MED/20181468; Berger JR; Major EO; Department of Neurology, University of Kentucky College of; Medicine, Lexington 40536-0284, USA.; Before the AIDS epidemic, progressive multifocal leukoencephalopathy (PML) was a rare disorder occurring most often in association with leukemia and lymphoma. Current estimates indicate that PML ultimately develops in up to 5% of all patients with AIDS. This demyelinating disease results from infection with JC virus,
Neurologic manifestations of toxoplasmosis in AIDS.: Semin Neurol. 1999;19(2):201-11. Unique Identifier : AIDSLINE MED/20181469; Cohen BA; Department of Neurology, Northwestern University Medical School,; Chicago Illinois 60611, USA.; Central nervous system (CNS) toxoplasmosis is the most common cause of cerebral mass lesions in AIDS patients. Toxoplasma gondii is commonly acquired through ingestion of contaminated meats resulting in latent infection. With the onset of immunosuppression, it may preferentially infect the CNS, resulting in a wide ran
Lymphoma of the central nervous system in AIDS.: Semin Neurol. 1999;19(2):213-21. Unique Identifier : AIDSLINE MED/20181470; Ciacci JD; Tellez C; VonRoenn J; Levy RM; Department of Neurological Surgery, The Johns Hopkins Hospital,; Baltimore, Maryland, USA.; Central nervous system (CNS) lymphoma is a common complication of patients with HIV infection occurring in as many as 20% of patients with AIDS. This article reviews current observations on primary CNS lymphoma and systemic AIDS-related lymphoma with CNS involvement. Clinical featu
Cerebrospinal fluid analysis for the diagnosis of human immunodeficiency virus-related neurologic diseases.: Semin Neurol. 1999;19(2):223-33. Unique Identifier : AIDSLINE MED/20181471; Weber T; Neurologische Klinik, Marienkrankenhaus Hamburg, Germany.; Although early attempts demonstrated increased amounts of p24 antigen in the cerebrospinal fluid (CSF) of AIDS patients with dementia (HADC), gene amplification based assays have recently shown a correlation between the HI virus load in CSF and dementia. Although these correlations
Hepatitis B, C and human immunodeficiency virus infections in multiply-injected kala-azar patients in Delhi.: Scand J Infect Dis. 2000;32(1):3-6. Unique Identifier : AIDSLINE MED/20178813; Singh S; Dwivedi SN; Sood R; Wali JP; Department of Laboratory Medicine, All India Institute of Medical; Sciences, New Delhi. ssingh@medinst.ernet.in; Sera from 164 patients with parasitologically confirmed kala-azar and 100 patients with non-kala-azar Delhite in 2 Delhi hospitals were tested for anti-human immunodeficiency (anti-HIV) and anti-hepatitis C virus (anti-HCV) antibodies and hepatitis B surface antigens to determine which group is more likely to contract
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.: Science. 2000 Apr 7;288(5463):136-40. Unique Identifier : AIDSLINE MED/20217223; Loots GG; Locksley RM; Blankespoor CM; Wang ZE; Miller W; Rubin EM; Frazer KA; Genome Sciences Department, Lawrence Berkeley National; Laboratory, Berkeley, CA 94720, USA.; Long-range regulatory elements are difficult to discover experimentally; however, they tend to be conserved among mammals, suggesting that cross-species sequence comparisons should identify them. To search for regulatory sequences, we examined about 1 megabase of orthologous human and mouse sequences for conserved non
Study of HIV transmission sparks ethics debate [news]: Science. 2000 Apr 7;288(5463):22-3. Unique Identifier : AIDSLINE MED/20226941; Vogel G
AIDS research head to retire from NIH [news]: Science. 2000 Apr 7;288(5463):25-6. Unique Identifier : AIDSLINE MED/20226942; Cohen J
Biochemistry. Chemical tags speed delivery into cells [news]: Science. 2000 Apr 7;288(5463):28-9. Unique Identifier : AIDSLINE MED/20226946; Service RF
HIV-1 nomenclature proposal [letter]: Science. 2000 Apr 7;288(5463):55-6. Unique Identifier : AIDSLINE MED/20226950; Robertson DL; Anderson JP; Bradac JA; Carr JK; Foley B; Funkhouser RK; Gao F; Hahn BH; Kalish ML; Kuiken C; Learn GH; Leitner T; McCutchan F; Osmanov S; Peeters M; Pieniazek D; Salminen M; Sharp PM; Wolinsky S; Korber B
NIMH/APPC workgroup on behavioral and biological outcomes in HIV/STD prevention studies: a position statement.: Sex Transm Dis. 2000 Mar;27(3):127-32. Unique Identifier : AIDSLINE MED/20189177; Pequegnat W; Fishbein M; Celentano D; Ehrhardt A; Garnett G; Holtgrave D; Jaccard J; Schachter J; Zenilman J; Center for Mental Health Research on AIDS, National Institute of; Mental Health, National Institutes of Health, Bethesda, Maryland; 20814, USA.
Prevalence and risk factors for human herpesvirus 8 infection in northern Cameroon.: Sex Transm Dis. 2000 Mar;27(3):159-64. Unique Identifier : AIDSLINE MED/20189184; Rezza G; Tchangmena OB; Andreoni M; Bugarini R; Toma L; Bakary DK; Glikoutou M; Sarmati L; Monini P; Pezzotti P; Ensoli B; Laboratory of Epidemiology, Istituto Superiore di Sanita, Rome,; Italy. g.rezza@iss.it; BACKGROUND: The modes of transmission of HHV-8 are still unclear. GOAL: To evaluate the distribution and transmission of HHV-8 infection. DESIGN: Serosurvey conducted in a Cameroon hospital among 292 persons, including children (5-10 years), adolescents (15-20 years), and adults
Prevalence of hepatitis G virus in patients with hemophilia and their steady female sexual partners.: Sex Transm Dis. 2000 Mar;27(3):178-82. Unique Identifier : AIDSLINE MED/20189188; Yeo AE; Matsumoto A; Shih JW; Alter HJ; Goedert JJ; Department of Transfusion Medicine, Clinical Center, National; Institutes of Health, Bethesda, Maryland, USA.; BACKGROUND: Hepatitis G virus (HGV), also known as GB virus C, is a newly discovered Flavivirus that is transmissible by blood transfusion and other possible routes. OBJECTIVE: To study the risk of sexual transmission of HGV in female sexual partners of men with hemophilia (n = 161 couples). METHODS: Blood samples obt
Hypothesis: thalidomide embryopathy-proposed mechanism of action.: Teratology. 2000 Mar;61(3):189-95. Unique Identifier : AIDSLINE MED/20127971; Stephens TD; Fillmore BJ; Department of Biological Sciences, Idaho State University,; Pocatello, Idaho 83209, USA. steptren@isu.edu; We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates alphav and beta3 integrin subunit genes. The resulting alphav beta3 integrin pr
[HIV-associated lipodystrophy syndrome (HALS). The Danish Society of Infectious Diseases]: Ugeskr Laeger. 2000 Mar 20;162(12):1714. Unique Identifier : AIDSLINE MED/20209748; Andersen O; Haugaard SB; Nielsen JO; H:S Hvidovre Hospital, infektionsmedicinsk afdeling.
Predominant subpopulations of T lymphocytes in the mammary gland secretions during lactation and intraepithelial T lymphocytes in the intestine of dairy cows.: Vet Immunol Immunopathol. 2000 Mar 15;73(3-4):233-40. Unique Identifier : AIDSLINE MED/20180223; Asai K; Komine Y; Kozutsumi T; Yamaguchi T; Komine K; Kumagai K; T-Cell Research Institute, in Bldg. ICR 6-6-3, Minami-Yoshinari,; Aoba-Ku, Sendai, Japan. tcr@tree.or.jp; Lymphocytes obtained from mammary gland secretions (MGS) during lactation or the dry period of dairy cows were simultaneously analyzed and compared to ileal intraepithelial lymphocytes (IEL) and peripheral blood lymphocytes (PBL) using monoclonal antibodies (mAb) specific for bovine leukocyte differentiation antigens.
Vaccination with feline immunodeficiency virus induces CD4 epitope masking by soluble factors.: Vet Immunol Immunopathol. 2000 Mar 15;73(3-4):343-52. Unique Identifier : AIDSLINE MED/20180232; Leutenegger CM; Holznagel E; Hofmann-Lehmann R; Aubert A; Tompkins MB; Lutz H; Clinical Laboratory, Department of Internal Veterinary Medicine,; University of Zurich, Zurich, Switzerland.; cmleutenegger@ucdavis.edu; Soluble factors are important effector mechanisms to control for lentiviral replication. Vaccination of cats with recombinant outer surface proteins (SU) of the FIV envelope protein in combination with complete Freund adjuvant (CFA) and rabies nucleocapsid (NC) protein led to significantly reduced viral loads [Leutene
Comparative in vitro metabolism of indinavir in primates--a unique stereoselective hydroxylation in monkey.: Xenobiotica. 2000 Feb;30(2):117-29. Unique Identifier : AIDSLINE MED/20181048; Chiba M; Nishime JA; Neway W; Lin Y; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, PA 19486, USA. Masato_Chiba@merck.com; 1. The in vitro metabolism of indinavir (CRIXIVAN, MK-0639, L-735,524), an HIV protease inhibitor, was evaluated using liver microsomes from cynomolgus monkey, rhesus monkey, chimpanzee and human. Indinavir exhibited marked species differences in meta
Spontaneous programmed cell death of peripheral blood mononuclear cells from HIV-infected persons is decreased with interleukin-15.: Yonsei Med J. 2000 Feb;41(1):112-8. Unique Identifier : AIDSLINE MED/20196477; Chang KH; Kim JM; Kim HY; Song YG; Choi YH; Park YS; Cho JH; Hong SK; Department of Internal Medicine, Yonsei University College of; Medicine, Seoul, Korea.; Interleukin 15 (IL-15) is an important regulatory cytokine in cellular immunity. In vitro replacement of IL-15 has been shown to enhance immunity in Human immunodeficiency virus type 1 (HIV-1) infected lymphocytes. We evaluated the effect of IL-15 on the survival of peripheral blood mononuclear cells of HIV patients b
CpG DNA induces stronger immune responses with less toxicity than other adjuvants.: Vaccine. 2000 Mar 6;18(17):1755-62. Unique Identifier : AIDSLINE MED/20165128; Weeratna RD; McCluskie MJ; Xu Y; Davis HL; Loeb Health Research Institute at the Ottawa Hospital, 725; Parkdale Avenue, Ottawa, Canada.; The ability to augment protective immune responses with minimal side effects is quintessential for a good adjuvant. This study has compared various adjuvants that are used in animal research (Freund s complete and incomplete adjuvants, Titermax Gold), are licensed for human use (alum), or are in clinical testing for h
Therapeutic vaccination against HSV-2: influence of vaccine formulation on immune responses and protection in mice.: Vaccine. 2000 Mar 6;18(17):1778-92. Unique Identifier : AIDSLINE MED/20165131; Mohamedi SA; Heath AW; Jennings R; Sheffield Institute for Vaccine Studies and Division of Molecular; and Genetic Medicine, "F" Floor, University of Sheffield Medical; School, Beech Hill Road, Sheffield, UK.; Therapeutic immunisation may represent a means of influencing viral infections that persist in the host by modulating the nature or level of host immunity. To assess the influence of the form of the antigenic stimulus on immunity to type-2 herpes simplex virus (HSV-2), mice pre-infected with sublethal doses of HSV-2 w
Microparticles in MF59, a potent adjuvant combination for a recombinant protein vaccine against HIV-1.: Unique Identifier : AIDSLINE MED/20165132; O'Hagan DT; Ugozzoli M; Barackman J; Singh M; Kazzaz J; Higgins K; Vancott TC; Ott G; Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608,; USA. derek_ohagan@cc.chiron.com; Novel adjuvant formulations involving PLG microparticles with entrapped recombinant protein antigens (env gp120 and p24 gag) from human immunodeficiency virus type-1 (HIV-1), dispersed in the emulsion adjuvant MF59 were evaluated as potential HIV-1 vaccine candidates in mice and baboons. In mice, the adjuvant combinat
DNA immunization utilizing a herpes simplex virus type 2 myogenic DNA vaccine protects mice from mortality and prevents genital herpes.: Vaccine. 2000 Mar 6;18(17):1837-46. Unique Identifier : AIDSLINE MED/20165137; Gebhard JR; Zhu J; Cao X; Minnick J; Araneo BA; DNA Vaccines and Gene Transfer, Pharmadigm Inc, 2401 Foothill; Drive, Salt Lake City, UT 84109, USA. jgebhard@pharmadigm.com; A gene transfer vector for DNA immunization was developed in which the promoter was derived from the murine muscle creatine kinase (MCK) gene; a gene expressed only in differentiated skeletal muscle. In vitro, we observed high-level, but unrestricted, gene expression from the cytomegal
Immunogenicity of Ty-VLP bearing a CD8(+) T cell epitope of the CS protein of P. yoelii: enhanced memory response by boosting with recombinant vaccinia virus.: Vaccine. 2000 Mar 6;18(17):1863-9. Unique Identifier : AIDSLINE MED/20165140; Oliveira-Ferreira J; Myahira Y; Layton GT; Savage N; Esteban M; Rodriguez D; Rodriguez JR; Nussenzweig RS; Zavala F; Department of Immunology, Instituto Oswaldo Cruz-FIOCRUZ, Rio de; Janeiro, Brazil. lila@gene.dbbm.fiocruz.br; We characterized the immunogenicity of the hybrid Ty-virus-like carrying the CD8(+) T cell epitope (SYVPSAEQI) of the circumsporozoite (CS) protein of Plasmodium yoelii (TyCS-VLP), a rodent malaria parasite. Balb/c mice were immunized with hybrid TyCS-VLP, and their CS-specific CD8(+) T cell response was quantitativel
Cytologic and biomolecular diagnosis of polyomavirus infection in urine specimens of HIV-positive patients.: Acta Cytol. 2000 Mar-Apr;44(2):205-10. Unique Identifier : AIDSLINE MED/20204780; Boldorini R; Zorini EO; Vigano P; Nebuloni M; Mena M; Monga G; Dipartimento di Scienze Mediche, Facolta di Medicina e; Chirurgia, Universita del Piemonte Orientale Amedeo Avogadro,; Novara, Italy.; OBJECTIVE: To evaluate the frequency of human polyomavirus reactivation in urine specimens from HIV-positive patients; compare the sensitivity of cytology, immunohistochemistry and molecular biology; differentiate viral genotypes; and correlate the results with urinary cytologic abnormalities. STUDY DESIGN: Urine spec
Fine needle aspiration of cryptococcal lymphadenitis: further observations using autofluorescence [letter]: Acta Cytol. 2000 Mar-Apr;44(2):281-2. Unique Identifier : AIDSLINE MED/20204796; Wright CA; Leiman G; Benatar B
Antipruritic action of thalidomide.: Acta Derm Venereol. 2000 Jan-Feb;80(1):24-5. Unique Identifier : AIDSLINE MED/20184852; Daly BM; Shuster S; Dermatology Department, Burnley General Hospital, UK.; The effect of thalidomide on itch was studied in 11 patients with chronic pruritus from psoriasis, eczema, nodular prurigo, senile pruritus and primary biliary cirrhosis. Itch, assessed subjectively by the patients on a 10 cm line and measured objectively as nocturnal scratch movement, was decreased by thalidomide 200
Ashy dermatosis in an HIV antibody-positive patient [letter]: Acta Derm Venereol. 2000 Jan-Feb;80(1):78-9. Unique Identifier : AIDSLINE MED/20184881; Molinero J; Vilata JJ; Nagore E; Obon L; Grau C; Aliaga A
Screening for HIV-associated distal-symmetric polyneuropathy in CDC-classification stages 1, 2, and 3.: Acta Neurol Scand. 2000 Mar;101(3):183-7. Unique Identifier : AIDSLINE MED/20168458; Husstedt IW; Evers S; Reichelt D; Grotemeyer KH; Kammer-Suhr B; Bockenholt S; Heese C; Department of Neurology, WWU Munster, Germany.; OBJECTIVES: A total of 670 patients were screened for distal symmetric HIV-associated polyneuropathy during CDC stages 1-3 and its correlation to immunological deterioration. MATERIAL AND METHODS: Clinical examinations of 670 patients admitted to the neurological outpatient clinic at the Department of Neurology, Unive
Cryptosporidium parvum gene discovery.: Adv Exp Med Biol. 1999;473:241-7. Unique Identifier : AIDSLINE MED/20124590; Abrahamsen MS; Department of Veterinary PathoBiology, University of Minnesota; 55108, USA. abrah025@tc.umn.edu; Cryptosporidium parvum is a well-recognized cause of diarrhea in humans and animals throughout the world, and is associated with a substantial degree of morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS). At the present time, there is no effective therapy for treating or preventing infe
A Fe(3+)/DNA complex induces an anti-human immunodeficiency virus factor(s) in CD4+ lymphocyte cell lines.: Acta Virol. 1999 Feb;43(1):25-30. Unique Identifier : AIDSLINE MED/20136271; Nossik D; Kaplina E; Nossik N; Kalnina L; Tsutsumi R; Miura Y; Sera K; Itoh C; Sato S; Lvov D; D.I. Ivanovsky Institute of Virology, Russian Academy of Medical; Sciences, Moscow, Russia.; Numerous cytokines and chemokines are involved in inflammatory and immune response. Whereas some of them inhibit virus replication in vitro directly or increase the patients T4-lymphocyte level, others effects are not so clear. Using human immunodeficiency virus (HIV) and cell cultures we have studied the antiviral e
A careful neurologic examination should precede neuroimaging studies in HIV-infected patients with headache [editorial; comment]: AJNR Am J Neuroradiol. 2000 Mar;21(3):441-2. Unique Identifier : AIDSLINE MED/20192874; Berger JR; Nath A
Screening CT of the brain determined by CD4 count in HIV-positive patients presenting with headache [see comments]: AJNR Am J Neuroradiol. 2000 Mar;21(3):451-4. Unique Identifier : AIDSLINE MED/20192877; Graham CB 3rd; Wippold FJ 2nd; Pilgram TK; Fisher EJ; Smoker WR; Mallinckrodt Institute of Radiology, Washington University; Medical Center, St. Louis, MO 63110, USA.; BACKGROUND AND PURPOSE: Few studies have examined HIV-positive patients presenting with uncomplicated headache for clinical variables that might be predictive of those patients who would most benefit from CT. Because of the value of CD4 counts in predicting the relative risk of developing opportunistic infections and
Risk of HIV infection in the athletic setting [news]: Am Fam Physician. 2000 Mar 1;61(5):1561-2. Unique Identifier : AIDSLINE MED/20197399
HHS awards $527 million for HIV/AIDS care in high-incidence areas [news]: Am Fam Physician. 2000 Mar 15;61(6):1606. Unique Identifier : AIDSLINE MED/20212908
Dedicated AIDS units vs. scattered-bed units [news]: Am J Nurs. 2000 Mar;100(3):21. Unique Identifier : AIDSLINE MED/20224700; National Institute of Nursing Research.
Postexposure HIV prophylaxis [letter]: Am J Nurs. 1999 Dec;99(12):18. Unique Identifier : AIDSLINE MED/20202865; Yeargin P
Nursing science: who cares? [editorial]: Am J Nurs. 1999 Dec;99(12):7. Unique Identifier : AIDSLINE MED/20202858; Mason DJ
Conference roundup: HIV and AIDS [news]: Ann Intern Med. 2000 Apr 18;132(8):685-6. Unique Identifier : AIDSLINE MED/20216517; Kane B
Perinatal drug abuse in KK Women's and Children's Hospital.: Ann Acad Med Singapore. 1999 Nov;28(6):795-9. Unique Identifier : AIDSLINE MED/20136321; Agarwal P; Rajadurai VS; Bhavani S; Tan KW; Department of Neonatology, KK Women's and Children's Hospital,; Singapore.; No local figures are available in Singapore on the incidence of perinatal drug abuse and its effect on the foetus and the neonate. The objectives of this study were to determine the incidence of perinatal drug abuse and neonatal abstinence syndrome; to identify a maternal profil
Atypical mycobacterium infection with sporotrichoid spread in a patient with human immunodeficiency virus.: Ann Acad Med Singapore. 1999 Nov;28(6):846-8. Unique Identifier : AIDSLINE MED/20136331; Tan HH; Chan RK; National Skin Centre, Singapore.; A case of Mycobacterium marinum infection presenting with a sporotrichoid spread in a HIV positive Chinese male is presented. The patient responded to oral cotrimoxazole treatment. A brief review of the literature concerning atypical mycobacterial infection presenting in such a fashion is discussed.
A case report of adult T-cell leukaemia/lymphoma (ATLL).: Ann Acad Med Singapore. 1999 Nov;28(6):867-70. Unique Identifier : AIDSLINE MED/20136337; Hwang WY; Tien SL; Tan PH; Department of Haematology, Singapore General Hospital, Singapore.; Adult T-cell leukaemia/lymphoma (ATLL) is a unique disease with distinct manifestations, a characteristic phenotype and a likely retroviral aetiology. It is unusual in Southeast Asia, though more commonly seen in some countries like Japan . We report a case of this disease in a 71-ye
Active surveillance of hepatitis C infection in the UK and Ireland.: Arch Dis Child. 2000 Apr;82(4):286-91. Unique Identifier : AIDSLINE MED/20200073; Gibb DM; Neave PE; Tookey PA; Ramsay M; Harris H; Balogun K; Goldberg D; Mieli-Vergani G; Kelly D; Department of Epidemiology and Public Health, Institute of Child; Health, London, UK. d.gibb@ctu.mrc.ac.uk; AIM: To investigate the prevalence, distribution, and clinical details of paediatric hepatitis C virus (HCV) infection in the UK and Ireland . METHODS: Active monthly surveillance questionnaire study coordinated through the British P
Sputum induction for the diagnosis of pulmonary tuberculosis in infants and young children in an urban setting in South Africa.: Arch Dis Child. 2000 Apr;82(4):305-8. Unique Identifier : AIDSLINE MED/20200077; Zar HJ; Tannenbaum E; Apolles P; Roux P; Hanslo D; Hussey G; Department of Paediatrics and Child Health, Red Cross War; Memorial Children's Hospital, University of Cape Town, South; Africa. heather@rmh.uct.ac.za; BACKGROUND: Bacteriological confirmation of pulmonary tuberculosis is difficult in infants and young children. In adults and older children, sputum induction has been successfully used; this technique has not been tested in younger children. AIMS: To investigate whether sputum induction can be successfully performed i
The host response in malaria and depression of defence against tuberculosis.: Ann Trop Med Parasitol. 1999 Oct;93(7):669-78. Unique Identifier : AIDSLINE MED/20180558; Enwere GC; Ota MO; Obaro SK; Medical Research Council Laboratories, Fajara, The Gambia.; Malaria causes significant morbidity and mortality world-wide. Both asymptomatic and symptomatic malarial infections cause immune depression, which predisposes the host to infection with other microorganisms. Specific clinical investigations have shown, for example, that those with malaria-attributable anaemia are par
Malaria in pregnancy and its consequences for the infant in rural Malawi.: Unique Identifier : AIDSLINE MED/20180551; Verhoeff FH; Brabin BJ; Chimsuku L; Kazembe P; Broadhead RL; Maternal malaria and anaemia, pregnancy and infant outcomes are reviewed among a cohort of mothers and their babies living in Chikwawa district, southern Malawi . Overall, 4104 women were screened at first antenatal visit and 1523 at delivery. Factors independently associated with m
The placenta in malaria: mechanisms of infection, disease and foetal morbidity.: Ann Trop Med Parasitol. 1999 Dec;93 Suppl 1:S35-42. Unique Identifier : AIDSLINE MED/20180552; Rogerson SJ; Beeson JG; Wellcome Trust Research Laboratories and Malaria Project, College; of Medicine, University of Malawi, Blantyre, Malawi.; srogerson@malawi.net; There is still much to discover about the reasons for the increased susceptibility of pregnant women to malaria or the pathogenesis of placental malaria. More systematic and detailed examination of the placenta may help. In many ways, the placenta can be seen as the flight recorder of the pregnancy; by examining it ca
Malaria in pregnancy: its relevance to safe-motherhood programmes.: Ann Trop Med Parasitol. 1999 Dec;93 Suppl 1:S59-66. Unique Identifier : AIDSLINE MED/20180554; Shulman CE; Department of Epidemiology and Public Health, London School of; Tropical Medicine and Hygiene, U.K. c.shulman@lshtm.ac.uk; Severe anaemia in pregnancy is an important contributor to maternal and perinatal morbidity and mortality. In sub-Saharan Africa severe anaemia in pregnancy is very common, the main causes being iron and folate deficiency, malaria, hookworm infestation and advanced HIV infection. Though most of these causes are preven
Priority areas for current research on malaria during pregnancy.: Ann Trop Med Parasitol. 1999 Dec;93 Suppl 1:S71-4. Unique Identifier : AIDSLINE MED/20180556; Menendez C; Epidemiology and Biostatistics Unit, Hospital Clinic, Barcelona,; Spain.
Clinical survival predictors in patients with advanced cancer.: Arch Intern Med. 2000 Mar 27;160(6):861-8. Unique Identifier : AIDSLINE MED/20199548; Vigano A; Bruera E; Jhangri GS; Newman SC; Fields AL; Suarez-Almazor ME; Division of Palliative Care Medicine, University of Alberta,; Edmonton, Canada. avigano@cha.ab.ca; BACKGROUND: The clinical and epidemiological relevance of different prognostic factors for survival in patients with advanced or terminal cancer remains controversial. PURPOSES: To establish the survival of patients with cancer after diagnosis of terminal disease and to determine the predictors of survival. METHODS: A
Abnormal distribution of gammadelta T lymphocytes in Graves' disease and insulin-dependent diabetes type 1.: Arch Immunol Ther Exp (Warsz). 2000;48(1):39-42. Unique Identifier : AIDSLINE MED/20185305; Kretowski A; Mysliwiec J; Kinalska I; Department of Endocrinology, University Medical School,; Bialystok, Poland. akretows@amb.ac.bialystok.pl; There is an increasing evidence that CD3+ cells, bearing gammadelta T cell receptors representing a minor subpopulation of T cells in the peripheral blood of humans are involved in the development of autoimmunity. The aim of the present study was determination of the gammadelta T cell subpopulation levels in the perip
Retroviruses and primate evolution.: Bioessays. 2000 Feb;22(2):161-71. Unique Identifier : AIDSLINE MED/20120563; Sverdlov ED; Institute of Molecular Genetics RAS, Kurchatov Sq., 123182; Moscow, Russia. eds@glasnet.ru; Human endogenous retroviruses (HERVs), probably representing footprints of ancient germ-cell retroviral infections, occupy about 1% of the human genome. HERVs can influence genome regulation through expression of retroviral genes, either via genomic rearrangements following HERV integrations or through the involvement
[Tuberculosis, AIDS, and antiretroviral therapy (letter; comment)]: Rev Clin Esp. 1999 Dec;199(12):858. Unique Identifier : AIDSLINE MED/20152042; Pedreira JD; Pita S; Juega J; Lopez-Calvo S; Castro MA
Antigen processing and presentation by intestinal epithelial cells - polarity and complexity.: Immunol Today. 2000 Mar;21(3):123-8. Unique Identifier : AIDSLINE MED/20156033; Hershberg RM; Mayer LF; Divisions of Gastroenterology and Genetics, Brigham and Women's; Hospital, Harvard Medical School, Boston, MA 02115, USA.; The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epi
Type-1 and type-2 cytokines in human decidual tissue and trophoblasts from normal and abnormal pregnancies detected by reverse transcriptase polymerase chain reaction (RT-PCR).: Am J Reprod Immunol. 1999 Dec;42(6):361-8. Unique Identifier : AIDSLINE MED/20086178; Vives A; Balasch J; Yague J; Quinto L; Ordi J; Vanrell JA; Department of Obstetrics and Gynecology, Faculty of Medicine,; University of Barcelona, Hospital Clinic i Provincial-IDIBAPS,; Spain.; PROBLEM: Cytokine expression at the maternal fetal interface has been well documented in rodents, but data in the human are scanty and controversial. METHOD OF STUDY: We examined cytokine expression of human decidua and trophoblasts by semiquantitative visual grading of reverse transcriptase polymerase chain reaction
Comparison of lymphocyte populations in cutaneous and electrical burn patients: a clinical study.: Burns. 2000 May;26(3):229-32. Unique Identifier : AIDSLINE MED/20203631; Deveci M; Sengezer M; Bozkurt M; Eski M; Inal A; Department of Plastic and Reconstructive Surgery and Burn Centre,; Gulhane Military Medical Academny, Ankara, Turkey.; mdeveci98@yahoo.com; Immunosuppression following thermal injury has been noted in recent years. Both cellular and humoral immune systems have been reported to be affected. The present study aimed to compare the quantitative differences between cutaneous and electrical burn patients in respect to the partition and levels of lymphocyte popu
Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations.: DNA Cell Biol. 2000 Mar;19(3):157-65. Unique Identifier : AIDSLINE MED/20210726; Boyle CM; Robinson HL; Department of Pathology, University of Massachusetts Medical; School, Worcester, USA.; DNA-raised antibody (Ab) responses have been compared for the dependence on CD4+ and CD8+ cells, the longevity of functional antigen (Ag) expression, and the nature of the Ag-presenting cell after intramuscular (i.m.) and gene gun inoculations. A plasmid expressing the hemagglutinin (HA) glycoprotein of influenza viru
Vpr-GFP virion particle identifies HIV-infected targets and preserves HIV-1Vpr function in macrophages and T-cells.: DNA Cell Biol. 2000 Mar;19(3):179-88. Unique Identifier : AIDSLINE MED/20210728; Muthumani K; Montaner LJ; Ayyavoo V; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp
Non-nucleoside reverse transcriptase inhibitor resistance among patients failing a nevirapine plus protease inhibitor-containing regimen.: AIDS. 2000 Jan 28;14(2):F1-7. Unique Identifier : AIDSLINE MED/20170570; Casado JL; Hertogs K; Ruiz L; Dronda F; Van Cauwenberge A; Arno A; Garcia-Arata I; Bloor S; Bonjoch A; Blazquez J; Clotet B; Larder B; Infectious Diseases Unit, Ramon y Cajal Hospital, Madrid, Spain.; jcasado@hrc.insalud.es; OBJECTIVE: To determine the rate of nevirapine resistance in patients failing a nevirapine plus protease inhibitor (PI)-based regimen, and whether these isolates remain susceptible to other non-nucleoside reverse transcriptase inhibitors (NNRTI). DESI
Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study.: AIDS. 2000 Jan 28;14(2):F17-23. Unique Identifier : AIDSLINE MED/20170572; Salomon H; Wainberg MA; Brenner B; Quan Y; Rouleau D; Cote P; LeBlanc R; Lefebvre E; Spira B; Tsoukas C; Sekaly RP; Conway B; Mayers D; Routy JP; McGill University AIDS Centre, the Reseau FRSQ-SIDA, Montreal,; Quebec, Canada.; OBJECTIVE: Prolonged treatment with antiretroviral drugs results in the selection of HIV-1 variants with mutations conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI and NNRTI) or to protease inhibitors (PI). There is serio
Phenotypic and genotypic resistance patterns of HIV-1 isolates derived from individuals treated with didanosine and stavudine.: Unique Identifier : AIDSLINE MED/20170571; Coakley EP; Gillis JM; Hammer SM; Department of Medicine, Beth Israel Deaconess Medical Center and; Harvard Medical School, Boston, Massachusetts 02215, USA.; OBJECTIVE: To evaluate the phenotypic susceptibilities and genotypic resistance patterns to both didanosine and stavudine of baseline and follow-up HIV-1 isolate pairs, derived from antiretroviral naive subjects treated with this dual nucleoside combi
CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1-infected long-term non-progressors. The Australian Long-Term Non-Progressor Study Group.: AIDS. 2000 Jan 28;14(2):103-8. Unique Identifier : AIDSLINE MED/20170573; Clegg AO; Ashton LJ; Biti RA; Badhwar P; Williamson P; Kaldor JM; Stewart GJ; Department of Immunology, Westmead Hospital, University of; Sydney, Australia.; OBJECTIVE: To determine the influence of CCR5 promoter polymorphisms on HIV-1 progression to AIDS and to evaluate the interaction between CCR5 structural polymorphisms and those occurring in the regulatory region of the same gene. PARTICIPANTS: Seventy-one HIV-1-infected long-term non-progressors with a CD4+ T cell co
Different immunologic profiles characterize HIV infection in highly active antiretroviral therapy-treated and antiretroviral-naive patients with undetectable viraemia. The Master Group.: AIDS. 2000 Jan 28;14(2):109-16. Unique Identifier : AIDSLINE MED/20170574; Clerici M; Seminari E; Suter F; Castelli F; Pan A; Biasin M; Colombo F; Trabattoni D; Maggiolo F; Carosi G; Maserati R; Cattedra di Immunologia, Universita degli Studi di Milano,; Padiglione L.I.T.A., Ospedale L. Sacco, Italy.; mago@mailserver.unimi.it; BACKGROUND: Suppression of human immunodeficiency virus (HIV) replication can be obtained in chronically infected individuals by highly active antiretroviral therapy (HAART) and can also be observed in antiretroviral-naive patients. The immunological correlates of these two situations were examined. DESIGN AND METHODS
Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study.: AIDS. 2000 Jan 28;14(2):117-21. Unique Identifier : AIDSLINE MED/20170575; Vernazza PL; Troiani L; Flepp MJ; Cone RW; Schock J; Roth F; Boggian K; Cohen MS; Fiscus SA; Eron JJ; Department of Medicine, Kantonsspital St. Gallen, Switzerland.; Pietro.Vernazza@Kssg.ch; OBJECTIVE: The amount of HIV in semen likely influences infectiousness. Antiretroviral therapy decreases HIV-RNA in semen, but data on HIV concentrations in semen in a large cohort of men with suppressed HIV-RNA in blood is unavailable. METHODS: Male patients with a treatment-induced reduction of HIV-RNA load in plasm
Natural history of serum HIV-1 RNA levels in 330 patients with a known date of infection. The SEROCO Study Group.: AIDS. 2000 Jan 28;14(2):123-31. Unique Identifier : AIDSLINE MED/20170576; Hubert JB; Burgard M; Dussaix E; Tamalet C; Deveau C; Le Chenadec J; Chaix ML; Marchadier E; Vilde JL; Delfraissy JF; Meyer L; Rouzioux; Department of Epidemiology, INSERM U292, Hopital de Bicetre, Le; Kremlin-Bicetre, France.; OBJECTIVE: To describe the spontaneous course, before the introduction of highly active antiretroviral therapy (HAART), of HIV-1 RNA during the AIDS-free period of the disease. To assess the predictive value of changes in HIV-1 RNA levels. DESIGN: A total of 330 patients with a known date of infection followed in the
B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS.: Unique Identifier : AIDSLINE MED/20170577; Grulich AE; Wan X; Law MG; Milliken ST; Lewis CR; Garsia RJ; Gold J; Finlayson RJ; Cooper DA; Kaldor JM; OBJECTIVES: To identify risk factors for non-Hodgkin s lymphoma (NHL) in people with HIV infection. DESIGN AND SETTING: Case-control study in Sydney, Australia . PARTICIPANTS AND METHODS: Two hundred and nineteen patients with AIDS-related NHL
Factors associated with clinical and virological failure in patients receiving a triple therapy including a protease inhibitor.: AIDS. 2000 Jan 28;14(2):141-9. Unique Identifier : AIDSLINE MED/20170578; Grabar S; Pradier C; Le Corfec E; Lancar R; Allavena C; Bentata M; Berlureau P; Dupont C; Fabbro-Peray P; Poizot-Martin I; Costagliola D; INSERM SC4 Faculte de Medecine St Antoine, Paris, France.; OBJECTIVE: To determine the predictors of virological and clinical failure in patients receiving a protease inhibitor as part of triple therapy. METHODS: From the French Hospital Database on HIV, 1402 protease inhibitor-naive patients starting a highly active antiretroviral therapy regimen with
Adherence to HAART in French HIV-infected injecting drug users: the contribution of buprenorphine drug maintenance treatment. The Manif 2000 study group.: AIDS. 2000 Jan 28;14(2):151-5. Unique Identifier : AIDSLINE MED/20170579; Moatti JP; Carrieri MP; Spire B; Gastaut JA; Cassuto JP; Moreau J; INSERM Research Unit 379, Marseille, France.; OBJECTIVES: To assess adherence to highly active antiretroviral therapies (HAART) in a cohort of French patients infected by HIV through injection drug use (IDU), and the impact on adherence of buprenorphine ambulatory drug maintenance treatment (DMT) which has been widely introduced since 1996. DESIGN: Adherence asse
A randomized, comparative study of lamivudine plus stavudine, with indinavir or nelfinavir, in treatment-experienced HIV-infected patients.: AIDS. 2000 Jan 28;14(2):157-61. Unique Identifier : AIDSLINE MED/20170580; Roca B; Gomez CJ; Arnedo A; Division of Infectious Diseases, Hospital General, Public Health; Department, Castellon, Spain.; OBJECTIVE: To compare adherence and clinical outcome with two modalities of highly active antiretroviral therapy (HAART), in HIV-infected patients. DESIGN: Randomized, open-label, prospective study. SETTING: Tertiary care centre in Spain . PATIENTS: A total of 112 non-naive HIV-infec
HIV-1 reverse transcriptase (RT) genotype and susceptibility to RT inhibitors during abacavir monotherapy and combination therapy.: AIDS. 2000 Jan 28;14(2):163-71. Unique Identifier : AIDSLINE MED/20170581; Miller V; Ait-Khaled M; Stone C; Griffin P; Mesogiti D; Cutrell A; Harrigan R; Staszewski S; Katlama C; Pearce G; Tisdale M; JW Goethe-Universitat, Zentrum der Inneren Medizin, Frankfurt,; Germany.; OBJECTIVE: To examine changes in HIV-1 susceptibility (genotype and phenotype) during an initial abacavir monotherapy phase followed by the addition of zidovudine and lamivudine. DESIGN: Sixty HIV-1 infected, antiretroviral therapy-naive subjects were
CMV retinitis recurs after stopping treatment in virological and immunological failures of potent antiretroviral therapy.: AIDS. 2000 Jan 28;14(2):173-80. Unique Identifier : AIDSLINE MED/20170582; Torriani FJ; Freeman WR; Macdonald JC; Karavellas MP; Durand DM; Jeffrey DD; Meylan PR; Schrier RD; Department of Medicine, University of California, San Diego, USA.; OBJECTIVES: To determine predictors of clinical relapse of cytomegalovirus ( CMV ) end-organ disease in a cohort of 17 HIV-infected patients with healed and treated CMV retinitis (CMVR) who responded to HAART with an increase i
Quality of life in asymptomatic- and symptomatic HIV infected patients in a trial of ritonavir/saquinavir therapy. The Prometheus Study Group.: AIDS. 2000 Jan 28;14(2):181-7. Unique Identifier : AIDSLINE MED/20170583; Nieuwkerk PT; Gisolf EH; Colebunders R; Wu AW; Danner SA; Sprangers MA; Department of Medical Psychology, Tropical Medicine and AIDS,; Academic Medical Center, University of Amsterdam, The; Netherlands. p.t.nieuwkerk@amc.uva.nl; OBJECTIVE: To compare the impact on quality of life (QoL) of treatment with ritonavir (RTV)/saquinavir (SQV) versus RTV/SQV/ stavudine (
High HIV seroprevalence associated with gonorrhea: New York City Department of Health, sexually transmitted disease clinics, 1990-1997.: AIDS. 2000 Jan 28;14(2):189-95. Unique Identifier : AIDSLINE MED/20170584; Torian LV; Makki HA; Menzies IB; Murrill CS; Benson DA; Schween FW; Weisfuse IB; Office of AIDS Research and HIV Serosurveys, The New York City; Department of Health, New York 10013, USA.; OBJECTIVE: To measure trends in HIV seroprevalence associated with gonorrhea in patients presenting to New York City Department of Health sexually transmitted disease (STD) clinics, 1990-1997 (n = 94 577). METHOD: Unlinked HIV-1 serosurvey using remnant serum originally drawn for routine serologic tests for syphilis (
Estimating the population impact in Australia of improved antiretroviral treatment for HIV infection.: AIDS. 2000 Jan 28;14(2):197-201. Unique Identifier : AIDSLINE MED/20170585; Law MG; Li Y; McDonald AM; Cooper DA; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research, The; University of New South Wales, Darlinghurst, Australia.; mlaw@nchecr.unsw.edu.au; OBJECTIVE: To estimate the reduction in AIDS incidence, if any, which has occurred in Australia following the availability of new combination antiretroviral treatments from 1995. DESIGN: Analyses were based on national surveillance data. METHODS: Back-projection analyses based o
Long-term effects of therapeutic vaccination with rgp 120 [letter]: AIDS. 2000 Jan 28;14(2):203-4. Unique Identifier : AIDSLINE MED/20170586; Lindenburg K; Langendam MW; Veenstra J; Miedema F; Coutinho R
Fas and Fas ligand are not involved in the suppression of HIV replication by CD8 cells [letter]: AIDS. 2000 Jan 28;14(2):204-5. Unique Identifier : AIDSLINE MED/20170587; Mackewicz CE; Ridha S; Levy JA
HIV-1 infection transmitted by serum droplets into the eye: a case report [letter]: AIDS. 2000 Jan 28;14(2):206-7. Unique Identifier : AIDSLINE MED/20170588; Eberle J; Habermann J; Gurtler LG
Hydroxyurea plus didanosine as maintenance therapy after 1 year on highly active antiretroviral therapy [letter]: AIDS. 2000 Jan 28;14(2):207-8. Unique Identifier : AIDSLINE MED/20170589; Barreiro P; de Mendoza C; Soriano V; Gonzalez-Lahoz J
HIV drug-resistance testing on archived samples to help current clinical decisions [letter]: AIDS. 2000 Jan 28;14(2):208-9. Unique Identifier : AIDSLINE MED/20170590; Dean GL; Fisher M; Loveday C
Prevalence of HIV and syphilis among high-risk groups in Bangladesh [letter]: AIDS. 2000 Jan 28;14(2):210-1. Unique Identifier : AIDSLINE MED/20170591; Azim T; Islam MN; Bogaerts J; Mian MA; Sarker MS; Fattah KR; Simmonds P; Jenkins C; Choudhury MR; Mathan VI
Hepatitis C viraemia in HIV-HCV co-infected patients having immune restoration with highly active antiretroviral therapy [letter]: AIDS. 2000 Jan 28;14(2):212. Unique Identifier : AIDSLINE MED/20170592; Perez-Olmeda M; Garcia-Samaniego J; Soriano V
Pulmonary immune responses during primary mycobacterium bovis- Calmette-Guerin bacillus infection in C57Bl/6 mice.: Am J Respir Cell Mol Biol. 2000 Mar;22(3):333-43. Unique Identifier : AIDSLINE MED/20160549; Fulton SA; Martin TD; Redline RW; Henry Boom W; Division of Infectious Diseases and the Institute of Pathology,; Case Western Reserve University and University Hospitals of; Cleveland, Cleveland, Ohio 44106-4984, USA. sxf24@po.cwru.edu; Mechanisms of protective immunity to mycobacterial infection in the lung remain poorly defined. In this study, T-cell subset expansion and cytokine expression in bronchoalveolar spaces, lung parenchyma, and mediastinal lymph nodes of mice infected intratracheally with Mycobacterium bovis-Calmette-Guerin bacillus (BCG)
Active concentration measurements of recombinant biomolecules using biosensor technology.: Unique Identifier : AIDSLINE MED/20025510 P; Zeder-Lutz G; Benito A
A bridge across the no-man's land [letter]: Br J Gen Pract. 1999 Apr;49(441):315. Unique Identifier : AIDSLINE MED/20201157; Dunford AP
A randomized trial of interferon alpha therapy for HIV type 1 infection.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):183-90. Unique Identifier : AIDSLINE MED/20173440; Haas DW; Lavelle J; Nadler JP; Greenberg SB; Frame P; Mustafa N; St. Clair M; McKinnis R; Dix L; Elkins M; Rooney J; Vanderbilt University Medical Center, Nashville, Tennessee 37212,; USA. david.w.haas@vanderbilt.edu; The immunologic and virologic efficacy and safety of interferon a (IFN-alpha) administered in combination with zidovudine (ZDV) and zalcitabine ( ddC ) was evaluated in HIV-infected subjects with CD4+ cell counts between 300 and 500 cells/ml and no more
Normalization of CD4+ cell numbers and reduced levels of memory CD8+ cells in blood and tonsillar tissue after highly active antiretroviral therapy in early HIV type-1 infection.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):191-201. Unique Identifier : AIDSLINE MED/20173441; Dyrhol-Riise AM; Voltersvik P; Rosok BI; Olofsson J; Asjo B; Department of Microbiology and Immunology, Center for Research in; Virology, University of Bergen, Norway. annema.riise@vir.uib.no; Antiretroviral therapy increases the number of both CD4+ and CD8+ T cells in the blood of HIV-1-positive patients with advanced disease. In the present study, we have examined the kinetics of CD4+ and CD8+ T cell restoration in blood and lymphoid tissue in asymptomatic HIV-1-positive individuals with high CD4+ cell co
Massive loss of sulfur in HIV infection.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):203-9. Unique Identifier : AIDSLINE MED/20173442; Breitkreutz R; Holm S; Pittack N; Beichert M; Babylon A; Yodoi J; Droge W; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Skeletal muscle tissue from SIV-infected macaques was previously found to contain abnormally high sulfate and low glutathione levels indicative of an excessive cysteine catabolism. We now confirm the peripheral tissue as a site of massive cysteine catabolism in HIV infection and have determined the urinary loss of sul
HIV type 1-induced inhibition of CD45 tyrosine phosphatase activity correlates with disease progression and apoptosis, but not with anti-CD3-induced T cell proliferation.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):211-9. Unique Identifier : AIDSLINE MED/20173443; Giovannetti A; Pierdominici M; Mazzetta F; Mazzone AM; Ricci G; Prozzo A; Pandolfi F; Paganelli R; Aiuti F; Division of Clinical Immunology and Allergy, La Sapienza; University of Rome, Italy.; The tyrosine phosphatase CD45 is a key positive element in multiple lymphocyte signaling pathways. To understand the contribution of CD45 to HIV-1-induced T cell hyporesponsiveness and apoptosis we evaluated the CD45-associated tyrosine phosphatase activity of lymphocytes from patients with different stages of HIV-1 d
Increased levels of soluble Fas receptor and Fas ligand in the cerebrospinal fluid of HIV-infected patients.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):221-6. Unique Identifier : AIDSLINE MED/20173444; Sporer B; Koedel U; Goebel FD; Pfister HW; Department of Neurology, Ludwig-Maximilians-University, Munich,; Germany.; Analyses of serum samples and blood cells have revealed a dysregulation of the Fas/Fas ligand (FasL) system during HIV infection, which may be related to disease progression. As Fas and FasL have been suggested to participate in brain injury in a variety of CNS disorders, the aim of this study was to determine (1) whe
Production and characterization of simian--human immunodeficiency virus-like particles.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):227-36. Unique Identifier : AIDSLINE MED/20173445; Yao Q; Kuhlmann FM; Eller R; Compans RW; Chen C; Department of Microbiology and Immunology, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.; qyao@bimcore.emory.edu; We have produced and characterized, in a baculovirus expression system, simian-human immunodeficiency virus-like particles (SHIV VLPs) containing SIV Gag and HIV envelope (Env) proteins. Recombinant SIV gag (SIVmac239) and full-length or cytoplasmic domain-truncated HIV env from either HIV BH10 or HIV 89.6 virus were
The HB-19 pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits attachment of T lymophocyte- and macrophage-tropic HIV to permissive cells.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):237-49. Unique Identifier : AIDSLINE MED/20173446; Nisole S; Krust B; Dam E; Bianco A; Seddiki N; Loaec S; Callebaut C; Guichard G; Muller S; Briand JP; Hovanessian AG; Unite de Virologie et Immunologie Cellulaire, URA CNRS 1930,; Institut Pasteur, Paris, France.; The HB-19 pseudopeptide 5[Kpsi(CH2N)PR]-TASP[psi(CH2N) indicating a reduced peptide bond], which binds the cell surface-expressed nucleolin, is a potent inhibitor of HIV infection. Here, by using primary T lymphocyte cultures and an experimental cell model to monitor HIV entry, we show that HB-19 inhibits in a dose-de
Role of nitric oxide in the promoting effect of HIV type 1 infection and of gp120 envelope glycoprotein on interleukin 4-induced IgE production by normal human mononuclear cells.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):251-8. Unique Identifier : AIDSLINE MED/20173447; Dugas N; Dereuddre-Bosquet N; Goujard C; Dormont D; Tardieu M; Delfraissy JF; Laboratorie Virus, Neurone, et Immunite, Faculte de Medecine; Paris Sud, Le Kremlin Bicetre, France.; nathalie.dugas@kb.u-psud.fr; Increased levels of serum IgE have been described in HIV-1 infection; however, mechanisms implicated in this immunoglobulin production remain unknown. In this study, we demonstrate that in vitro infection of human peripheral blood mononuclear cells (PBMCs) by HIV-1 monocytotropic (Ba-L) or lymphocytotropic (LAI) strai
Parameters influencing measurement of the Gag antigen-specific T-proliferative response to HIV type 1 infection.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):259-71. Unique Identifier : AIDSLINE MED/20173448; Schiller DS; Binley JM; Roux KH; Adamson CS; Jones IM; Krausslich HG; Hurley A; Markowitz M; Moore JP; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, New York 10016, USA.; We have analyzed factors that might influence the in vitro quantitation of the T-proliferative response to HIV-1 Gag antigens, a common and increasingly used clinical measurement of helper T cell function in the context of HIV-1 infection. We have compared the rate and extent of T cell proliferation in freshly prepare
Priming of strong, broad, and long-lived HIV type 1 p55gag-specific CD8+ cytotoxic T cells after administration of a virus-like particle vaccine in rhesus macaques.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):273-82. Unique Identifier : AIDSLINE MED/20173449; Paliard X; Liu Y; Wagner R; Wolf H; Baenziger J; Walker CM; Chiron Corporation, Emeryville, CA 94608-2916, USA.; Despite advances in the clinical management of HIV infection, using combinations of antiretroviral pharmaceuticals, a safe and efficacious vaccine is needed to limit the AIDS pandemic. It is now thought that an effective HIV-1 vaccine should prime both cross-neutralizing antibodies and long-lasting cytotoxic CD8+ T ly
Highly variable sequences in the env V3 region of HIV type 1 distributing among Thai carriers from 1995 to 1997.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):283-9. Unique Identifier : AIDSLINE +; Auwanit W; Ayuthaya PI; Duangchanda S; Mukai T; Kurata T; Ikuta K; Section of Serology, Institute for Immunological Science,; Hokkaido University, Sapporo, Japan.; The amino acid sequences of the Env V3 region of HIV-1 subtype E in Thailand were highly variable in the samples obtained from 1995 to 1997, compared with the previously reported sequences in samples obtained from 1990 to 1993. The sequences of the V3 region in the samples from f
Silent mutation in the V3 region characteristic of HIV type 1 env subtype B strains from injecting drug users in the former Soviet Union.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):291-4. Unique Identifier : AIDSLINE GENBANK/L06685; Bobkov AF; Lukashov VV; Goudsmit J; Weber JN; D.I. Ivanovsky Institute of Virology, Moscow, Russia.; bobkov@cityline.ru; New independent states of the former Soviet Union are facing a rapidly growing epidemic of HIV-1 among injecting drug users (IDUs). This epidemic is caused by three HIV-1 populations, one belonging to HIV-1 subtype A (IDU-A), another to subtype B (IDU-B), and the third being a recombinant of the IDU-A and IDU-B viruse
Genetic analysis of HIV type 2 in monotypic and dual HIV infections.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):295-8. Unique Identifier : AIDSLINE GENBANK/AF185821; Sarr AD; Sankale JL; Gueye-Ndiaye A; Essex M; Mboup S; Kanki PJ; Department of Immunology and Infectious Diseases and the Harvard; AIDS Institute, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; A significant level of genetic variation among HIV-1 and HIV-2 has been described. The interaction of specific HIV-2 subtypes with HIV-1 may serve to identify potential biological properties associated with dual infection. To genetically characterize the HIV-2 strains circulating in S
Different distribution of HIV type 1 genetic variants in European patients with distinct risk practices.: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):299-304. Unique Identifier : AIDSLINE +; Casado C; Urtasun I; Saragosti S; Chaix ML; de Rossi A; Cattelan AM; Dietrich U; Lopez-Galindez C; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, Madrid, Spain.; The use of two genetic markers has permitted the analysis of the distribution of two different human immunodeficiency virus type 1 (HIV-1) variants in patients of the homosexual (HO) and intravenous drug user (IDU) groups in distinct European countries. In Germany , Holland, and
Occurrence of additional NF-kappaB-binding motifs in the long terminal repeat region of South African HIV type 1 subtype C isolates [letter]: AIDS Res Hum Retroviruses. 2000 Feb 10;16(3):305-6. Unique Identifier : AIDSLINE GENBANK/AF183826; Hunt G; Tiemessen CT
Weekly alternating combination chemotherapy for good prognosis AIDS-related lymphoma.: Eur J Cancer. 2000 Feb;36(3):363-7. Unique Identifier : AIDSLINE MED/20208928; Bower M; Stern S; Fife K; Nelson M; Gazzard BG; Department of Oncology, Chelsea & Westminster Hospital, 369; Fulham Road, London, UK. m.bower@ic.ac.uk; Early studies reported that the major adverse prognostic factors in AIDS-related non-Hodgkin s lymphoma (ARL) are low CD4 cell count, prior AIDS defining diagnosis and poor performance status. Since 1989 we have adopted a prognosis-stratified approach for ARL. In this study, we ide
Lipodystrophy associated with protease inhibitors.: Br J Dermatol. 2000 Mar;142(3):496-500. Unique Identifier : AIDSLINE MED/20200739; Panse I; Vasseur E; Raffin-Sanson ML; Staroz F; Rouveix E; Saiag P; Departments of Dermatology, Internal Medicine V and; Histopathology, Hopital Ambroise Pare, Assistance; Publique-Hopitaux de Paris, 9 Avenue Charles de Gaulle, 92104; Boulogne, France.; Lipodystrophies, characterized by reduction of subcutaneous fat over part or all of the body surface, are uncommon. Their causes are unknown. Recently, lipodystrophy has been reported in human immunodeficiency virus (HIV)-infected patients taking protease inhibitors
Acquired immune deficiency syndrome-related hyperkeratotic Kaposi's sarcoma with severe lymphoedema: report of five cases.: Br J Dermatol. 2000 Mar;142(3):501-5. Unique Identifier : AIDSLINE MED/20200740; Hengge UR; Stocks K; Goos M; Department of Dermatology, Venereology and Allergology,; University of Essen, Hufelandstrasse 55, 45122 Essen, Germany.; ulrich.hengge@uni-essen.de; Kaposi s sarcoma (KS) is the most frequent neoplasm in acquired immune deficiency syndrome (AIDS) patients. Whereas typical cases present as erythematous, plaque or nodular lesions, hyperkeratotic variants of AIDS-associated KS are rare. We describe five patients with AIDS-associated KS with hyperkeratosis and lymphoe
Viral folliculitis on the face.: Br J Dermatol. 2000 Mar;142(3):555-9. Unique Identifier : AIDSLINE MED/20200754; Jang KA; Kim SH; Choi JH; Sung KJ; Moon KC; Koh JK; Department of Dermatology, Asan Medical Center, College of; Medicine, University of Ulsan, 388-1 Poongnap-Dong, Songpa-Gu,; Seoul 138-736, Korea.; The common clinical presentations of herpes simplex virus (HSV) and molluscum contagiosum (MC) are well known to dermatologists. However, folliculitis due to these viruses is an infrequently reported entity and might be considered a sign of immunosuppression [such as infection with human immunodeficiency virus, (HIV)]
Normolipaemic xanthomas in association with human immunodeficiency virus infection [letter]: Br J Dermatol. 2000 Mar;142(3):571-3. Unique Identifier : AIDSLINE MED/20234518; Ramsay HM; Garraido MC; Smith AG
Cutaneous squamous cell carcinoma with zosteriform metastases in a human immunodeficiency virus-infected patient [letter]: Br J Dermatol. 2000 Mar;142(3):573-4. Unique Identifier : AIDSLINE MED/20234519; Fearfield LA; Nelson M; Francis N; Bunker CB
Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring.: Br J Ophthalmol. 2000 Apr;84(4):408-12. Unique Identifier : AIDSLINE MED/20195476; Ghiasi H; Cai S; Perng GC; Nesburn AB; Wechsler SL; Ophthalmology Research, Cedars-Sinai Burns and Allen Research; Institute, Los Angeles, CA 90048, USA.; AIM: To determine the relative impact of CD4+ T cells and CD8+ T cells in protecting mice against ocular HSV-1 challenge. METHODS: CD4+ T cell knockout mice (CD4-/- mice), CD8+ T cell knockout mice (CD8-/- mice), and mice depleted for CD4+ or CD8+ T cells by antibody (CD4+ depleted and CD8+ depleted mice), were examin
Aminoglycoside-arginine conjugates that bind TAR RNA: synthesis, characterization, and antiviral activity.: Biochemistry. 2000 Mar 21;39(11):2838-52. Unique Identifier : AIDSLINE MED/20181655; Litovchick A; Evdokimov AG; Lapidot A; Departments of Organic Chemistry and Structural Biology, The; Weizmann Institute of Science, 76100 Rehovot, Israel.; Regulation of HIV gene expression is crucially dependent on binding of the trans-activator protein, Tat, to the trans-activation response RNA element, TAR, found at the 5 end of all HIV-1 transcripts. Tat-TAR interaction is mediated by a short arginine-rich domain of the protein. Disruption of this interaction could,
Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis.: Biochemistry. 2000 Mar 21;39(11):2912-20. Unique Identifier : AIDSLINE MED/20181663; Kaushik N; Talele TT; Pandey PK; Harris D; Yadav PN; Pandey VN; Department of Biochemistry and Molecular Biology, University of; Medicine and Dentistry-New Jersey Medical School, 185 South; Orange Avenue, Newark, New Jersey 07103, USA.; A natural mutation at codon 151 (Gln --> Met; Q151M) of HIV-1 RT has been shown to confer resistance to the virus against dideoxy nucleoside analogues [Shirasaka, T., et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 2398], suggesting that Gln 151 may be involved in conferring sensitivity to nucleoside analogues. To und
Single dose pharmacokinetics and bioavailability of nevirapine in healthy volunteers.: Biopharm Drug Dispos. 1999 Sep;20(6):285-91. Unique Identifier : AIDSLINE MED/20163634; Lamson MJ; Sabo JP; MacGregor TR; Pav JW; Rowland L; Hawi A; Cappola M; Robinson P; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877,; USA. mlamson@rdg.boehringer-ingelheim.com; The results of two randomized, single-dose, crossover bioavailability studies are presented which describe the pharmacokinetics and oral bioavailability of nevirapine , a novel nonnucleoside antiretroviral drug. In the first study 12 healthy male volun
Increase in CD95 (Fas/APO-1)-positive CD4+ and CD8+ T cells in peripheral blood derived from patients with autoimmune hepatitis or chronic hepatitis C with autoimmune phenomena.: J Gastroenterol Hepatol. 2000 Jan;15(1):69-75. Unique Identifier : AIDSLINE MED/20182669; Ogawa S; Sakaguchi K; Takaki A; Shiraga K; Sawayama T; Mouri H; Miyashita M; Koide N; Tsuji T; The First Department of Internal Medicine, Okayama University; Medical School, Japan.; BACKGROUND: The expressions of CD95 (Fas/APO-1) and Bcl-2 are determinants of apoptosis in normal lymphocytes, and abnormalities in their expressions might contribute to the induction of autoimmunity. In this study, we examined the expressions of CD95 and Bcl-2 on freshly isolated T and B cells from patients with auto
Rate of HIV transmission among Africans in UK "underestimated" [news]: BMJ. 2000 Mar 18;320(7237):735. Unique Identifier : AIDSLINE MED/20185414; Brown P
Recent advances: Dermatology.: BMJ. 2000 Mar 25;320(7238):850-3. Unique Identifier : AIDSLINE MED/20195546; Foley PA; University of Melbourne, Department of Medicine (Dermatology), St; Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia.; FOLEYP@svhm.org.au
Correlation between the immune response elicited in rabbits by env-recombinant avipox vaccines and the inhibition of HIV-1-specific functions.: FEMS Immunol Med Microbiol. 2000 Mar;27(3):211-8. Unique Identifier : AIDSLINE MED/20148484; Radaelli A; Gimelli M; Zanotto C; De Giuli Morghen C; Department of Pharmacology, University of Milan, Via Vanvitelli; 32, 20129, Milan, Italy.; The fine immunoreactivity of the rabbit humoral response elicited by four env-recombinant avipoxviruses and their ability to stimulate a memory T-cell response and a protective immunity have been studied. The antibody specificity was compared with the serum neutralizing activity and virus-specific T-cell proliferative
Impairment of T-cell functions with the progressive ascitic growth of a transplantable T-cell lymphoma of spontaneous origin.: FEMS Immunol Med Microbiol. 2000 Mar;27(3):247-55. Unique Identifier : AIDSLINE MED/20148489; Shanker A; Singh SM; School of Biotechnology, Banaras Hindu University, Varanasi,; India.; It has been observed that the progressive ascitic growth of a transplantable T-cell lymphoma of spontaneous origin, designated Dalton s lymphoma (DL), in a murine host induces inhibition of various immune responses and is associated with an involution of thymus accompanied by a massive depletion of the cortical region
Antenatal screening for HIV infection is improving in London.: Commun Dis Rep CDR Wkly. 2000 Feb 25;10(8):69. Unique Identifier : AIDSLINE MED/20201188
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 2000 Feb 25;10(8):77-80. Unique Identifier : AIDSLINE MED/20201191
Splenic smooth-muscle tumors in children with acquired immunodeficiency syndrome: report of two cases of this unusual location with evidence of an association with Epstein-Barr virus.: Virchows Arch. 2000 Feb;436(2):138-9. Unique Identifier : AIDSLINE MED/20216380; Barbashina V; Heller DS; Hameed M; Albanese E; Goldstein M; Dashefsky B; Dieudonne A; Chakraborty R; Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey; Medical School, Newark 07103, USA.; Smooth-muscle neoplasms are rarely located in the spleen. They have been previously reported in five cases of children with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). Two cases of children with HIV infection/AIDS with autopsy and surgical pathology evidence of multiple smoo
Antitumor effects on mouse melanoma elicited by local secretion of interleukin-12 and their enhancement by treatment with interleukin-18.: Cancer Invest. 2000;18(3):206-13. Unique Identifier : AIDSLINE MED/20217791; Nagai H; Hara I; Horikawa T; Fujii M; Kurimoto M; Kamidono S; Ichihashi M; Department of Dermatology, Kobe University School of Medicine,; Japan.; To investigate the mechanism of the antitumor effect of locally secreted interleukin-12 (IL-12), we introduced the IL-12 p35 and p40 cDNAs into mouse B16 melanoma cells. IL-12 gene-transfected B16 melanoma (B16/IL12) showed marked retardation of tumor growth when implanted subcutaneously into syngeneic mice. In these
Depression in patients with HIV infection.: Am J Health Syst Pharm. 2000 Feb 15;57(4):376-86; quiz 387-9. Unique Identifier : AIDSLINE MED/20177458; Penzak SR; Reddy YS; Grimsley SR; Department of Pharmacy Practice, Southern School of Pharmacy,; Mercer University, Atlanta, GA 30341-4155, USA.; penzak_sr@mercer.edu; The epidemiology, clinical features, and drug treatment of depression in HIV-infected patients are discussed. The lifetime prevalence of depression in patients infected with HIV has been estimated at 22-45%. The signs and symptoms of depression are similar in HIV-infected and noninfected patients, but patients with HI
Tricks of the trade in starting efavirenz therapy [letter]: Am J Health Syst Pharm. 2000 Mar 1;57(5):490-1. Unique Identifier : AIDSLINE MED/20174673; LeFlore DB; DeSilva KE
IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response.: Gene Ther. 1999 Oct;6(10):1705-12. Unique Identifier : AIDSLINE MED/99448024; Adris S; Klein S; Jasnis M; Chuluyan E; Ledda M; Bravo A; Carbone C; Chernajovsky Y; Podhajcer O; Gene Therapy Laboratory, Instituto de Investigaciones; Bioquimicas Fundacion Campomar, CONICET, FCEYN, Universidad de; Buenos Aires, Argentina.; In spite of the evidence that IL-10 has Th1-immunosuppressive and anti-inflammatory effects, it has been shown that IL-10 may reduce the tumorigenic capacity of certain tumor cell types. In order to characterize the responses elicited by IL-10, we explored the effect of transducing murine CT26 colon carcinoma cells wi
Gene transfer and expression of a non-viral polycation-based vector in CD4+ cells.: Gene Ther. 1999 Oct;6(10):1774-8. Unique Identifier : AIDSLINE MED/99448033; Puls R; Minchin R; Department of Pharmacology, University of Western Australia,; Western Australia, Australia.; CD4-selective targeting of an antibody-polycation-DNA complex was investigated. The complex was synthesized with the anti-CD4 monoclonal antibody B-F5, polylysine268 (pLL) and either the pGL3 control vector containing the luciferase reporter gene or the pGeneGrip vector containing the green fluorescent protein (GFP) g
Establishment of an optimised gene transfer protocol for human primary T lymphocytes according to clinical requirements.: Gene Ther. 1999 Oct;6(10):1788-92. Unique Identifier : AIDSLINE MED/99448036; Ayuk F; Li Z; Kuhlcke K; Lindemann C; Schade U; Eckert HG; Zander A; Fehse B; Bone Marrow Transplantation, University Hospital Eppendorf,; Hamburg, Germany.; Current gene therapeutic protocols directed towards the treatment of inherited disorders (eg ADA-SCID) and viral infections (eg AIDS), as well as adoptive immunotherapy approaches are based on the use of genetically modified lymphocytes. Since only insufficient transduction of T cells is obtained using existing techni
HIV/AIDS infection [letter]: J Can Dent Assoc. 2000 Mar;66(3):123-4. Unique Identifier : AIDSLINE MED/20224382; Sonntag CB
HIV/AIDS infection[letter]: J Can Dent Assoc. 2000 Mar;66(3):123-4. Unique Identifier : AIDSLINE MED/20234546; Klotz M
"Amplified perversity": trends in heterosexual HIV [editorial; comment]: AIDS Patient Care STDS. 1999 Dec;13(12):683-8. Unique Identifier : AIDSLINE MED/20207933; Laurence J
Genital HIV shedding in women.: AIDS Patient Care STDS. 1999 Dec;13(12):695-701. Unique Identifier : AIDSLINE MED/20207935; Iversen AK; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark. aifrhm@inet.uni2.dk; Heterosexual transmission of HIV is the predominant transmission mode among adults world-wide, while mother-to-child transmission accounts for the majority of HIV infections in children. Factors that affect genital tract shedding of HIV virus or cell-associated provirus in women are probably important determinants of
Sexually transmitted infections in female rape victims [see comments]: AIDS Patient Care STDS. 1999 Dec;13(12):703-8. Unique Identifier : AIDSLINE MED/20207936; Holmes M; Department of Obstetrics/Gynecology, Medical University of South; Carolina, Charleston, USA. holmesm@musc.edu; Sexual assault is a common occurrence that carries significant physical and mental health morbidity. Some of the most common concerns expressed by sexual assault victims can be allayed by addressing the risks of rape-related sexually transmitted infections. Although exact risks cannot be accurately quantified, it is i
Female genital mutilation: complications and risk of HIV transmission [see comments]: AIDS Patient Care STDS. 1999 Dec;13(12):709-16. Unique Identifier : AIDSLINE MED/20207937; Brady M; Hostos Community College, Bronx, New York, USA. BradyFNP@aol.com; There are over 100 million girls and women who have undergone female genital mutilation (FGM). The World Health Organization (WHO) estimates that another 2 million are subject to it every year. FGM is practiced in many countries, especially Africa and parts of the Middle East. Various
Heterosexual anal intercourse: prevalence, cultural factors, and HIV infection and other health risks, Part I.: AIDS Patient Care STDS. 1999 Dec;13(12):717-30. Unique Identifier : AIDSLINE MED/20207938; Halperin DT; International Center for HIV/AIDS Research and Clinical Training; in Nursing, University of California, San Francisco, USA.; dhalp@itsa.ucsf.edu; Studies of heterosexual HIV transmission have consistently found anal intercourse to be a highly predictive risk factor for seroconversion. Yet most AIDS prevention messages targeted at heterosexuals, presumably influenced by cultural taboos against acknowledging this sexual practice, continue to emphasize vaginal and
Condom availability for HIV/STD prevention [see comments]: AIDS Patient Care STDS. 1999 Dec;13(12):731-7. Unique Identifier : AIDSLINE MED/20207939; Cohen DA; Department of Public Health and Preventive Medicine, Louisiana; State University Medical Center, New Orleans, USA.; dcohen@lsumc.edu; Condom availability is a structural intervention that increases access to condoms. It is the most important strategy for the prevention of the sexual transmission of HIV/STDs in developing countries. While it is an integral component of many prevention programs, it is considered controversial in high school settings a
Contraceptive use and pregnancy decision making among women with HIV.: AIDS Patient Care STDS. 1999 Dec;13(12):739-46. Unique Identifier : AIDSLINE MED/20207940; Smits AK; Goergen CA; Delaney JA; Williamson C; Mundy LM; Fraser VJ; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri, USA.; HIV is a growing epidemic among women in the United States . This study seeks to determine if knowledge of HIV infection and of the benefits of prenatal zidovudine (ZDV) to decrease vertical HIV transmission is related to decisions about pregnancy planning, contraceptive and condom use,
Calcium may help with diarrhea [news]: AIDS Patient Care STDS. 1999 Dec;13(12):753. Unique Identifier : AIDSLINE MED/20207942
Ketoconazole may improve PI penetration [news]: AIDS Patient Care STDS. 1999 Dec;13(12):753. Unique Identifier : AIDSLINE MED/20207944
T-20 continues to look promising [news]: AIDS Patient Care STDS. 1999 Dec;13(12):753. Unique Identifier : AIDSLINE MED/20207943
Phase III trial of IL-2 [news]: AIDS Patient Care STDS. 1999 Dec;13(12):753-4. Unique Identifier : AIDSLINE MED/20207945
Amprenavir study results released [news]: AIDS Patient Care STDS. 1999 Dec;13(12):754. Unique Identifier : AIDSLINE MED/20207948
Reformulated ritonavir [news]: AIDS Patient Care STDS. 1999 Dec;13(12):754. Unique Identifier : AIDSLINE MED/20207946
Trial studies PI combination [news]: AIDS Patient Care STDS. 1999 Dec;13(12):754. Unique Identifier : AIDSLINE MED/20207947
Drug combination treats brain cancer [news]: AIDS Patient Care STDS. 1999 Dec;13(12):755. Unique Identifier : AIDSLINE MED/20207949
Stopping PCP prophylaxis [news]: AIDS Patient Care STDS. 1999 Dec;13(12):756. Unique Identifier : AIDSLINE MED/20207951
STD treatment and incidence [news]: AIDS Patient Care STDS. 1999 Dec;13(12):756. Unique Identifier : AIDSLINE MED/20207954
Risky sexual behavior among adolescent women.: J Soc Pediatr Nurs. 2000 Jan-Mar;5(1):15-25. Unique Identifier : AIDSLINE MED/20208005; Taylor-Seehafer M; Rew L; Center for Adolescent Health, People's Community Clinic, Austin,; TX, USA. Denk444357@aol.com; ISSUES AND PURPOSE: To review the epidemiology and etiology of risky sexual behavior in adolescent women, and to discuss implications for primary prevention. CONCLUSION: Adolescent women who participate in risky sexual behavior are at risk for sexually transmitted infections, including HIV. Black, Hispanic, and out-of
Disclosing the diagnosis of pediatric HIV infection: mothers' views.: J Soc Pediatr Nurs. 2000 Jan-Mar;5(1):5-14. Unique Identifier : AIDSLINE MED/20208004; Nehring WM; Lashley FR; Malm K; Southern Illinois University Edwardsville, USA. wnehrin@siue.edu; or flashle@siue.edu; ISSUES AND PURPOSE: The stigma of HIV infection creates barriers to disclosure. The purpose of this study was to identify to whom biological and foster mothers disclose the diagnosis of HIV infection, discuss their rationale, and describe the recipient s reactions. DESIGN AND METHODS: A descriptive, qualitative study
How does HIV cause AIDS? The homing theory.: Mol Med Today. 2000 Mar;6(3):108-11. Unique Identifier : AIDSLINE MED/20156920; Cloyd MW; Chen JJ; Wang I; Departments of Microbiology, Immunology and Pathology, University; of Texas Medical Branch, Galveston, TX 77555, USA. mcloyd@utmb.ed; The mechanism by which HIV causes depletion of CD4+ T cells in infected individuals remains unknown. Numerous theories have been proposed, but none can fully explain all of the events observed to occur in patients. Recent studies have shown that HIV binding to resting CD4+ T cells upregulates L-selectin, causing the c
[Epidemiologic study and prevention of AIDS in China]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1999 Jun;20(3):131-4. Unique Identifier : AIDSLINE MED/20147100; Zheng X
[Gene therapy of AIDS]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1999 Jun;20(3):178-80. Unique Identifier : AIDSLINE MED/20147113; Fang H; Hou Z; Tian F
Determinants of hospital admission among HIV-positive people in British Columbia.: CMAJ. 2000 Mar 21;162(6):783-6. Unique Identifier : AIDSLINE MED/20214047; Weber AE; Yip B; O'Shaughnessy MV; Montaner JS; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital.; BACKGROUND: This study was initiated to evaluate the demographic and clinical determinants of admission to hospital among HIV-positive men and women receiving antiretroviral therapy in British Columbia. METHODS: The analysis was restricted to participants enrolled in the HIV/AIDS Drug Treatment Program between Septemb
Natural transplacental infection of dairy calves with bovine immunodeficiency virus and estimation of effect on neonatal health.: Prev Vet Med. 2000 Feb 29;43(4):239-52. Unique Identifier : AIDSLINE MED/20181421; Scholl DT; Truax RE; Baptista JM; Ingawa K; Orr KA; O'Reilly KL; Jenny BF; Department of Epidemiology and Community Health, School of; Veterinary Medicine, Louisiana State University, Baton Rouge; 70803, USA. echdts@lsu.edu; Many experimental infection studies with bovine immunodeficiency virus (BIV) have been conducted, but neither virus transmission under natural conditions nor longitudinal clinical effects of naturally occurring infections in non-experimental populations are well explored. We tested the hypotheses that BIV is transmitt
Behavior changes & disease prevention: MCW research shows effectiveness of HIV/AIDS risk reduction interventions. Medical College of Wisconsin.: WMJ. 2000 Jan-Feb;99(1):41-3, 47. Unique Identifier : AIDSLINE MED/20215843; Kelly JA; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53202, USA. kdemming@mcw.edu; Many of the diseases that cause premature illness and death--including some cancers, heart disease, and AIDS--could be prevented if persons made behavior changes to reduce their risk for developing the illnesses. Over the past two decades, there have been great advances in our scientific understanding of how to promot
Inhibition of human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H activities by constituents of Juglans mandshurica.: Unique Identifier : AIDSLINE MED/20169681; Min BS; Nakamura N; Miyashiro H; Kim YH; Hattori M; From the stem-bark of Juglans mandshurica, two new naphthalenyl glucopyranosides, 1,4,8-trihydroxynaphthalene 1-O-[alpha-L-arabinofuranosyl-(1-->6)-beta-D-glucopyranoside] (1) and 1,4,8-trihydroxynaphthalene 1-O-beta-D-[6 -O-(3 ,5 -dihydroxy-4 -methoxybenzoyl)]glucopyranos- i de (4), and two new alpha-tetralonyl gluco
Determination of hydration kinetics of sulfaguanidine anhydrate in aqueous solution by calorimetry.: Chem Pharm Bull (Tokyo). 2000 Feb;48(2):208-10. Unique Identifier : AIDSLINE MED/20169683; Yoshihashi Y; Yonemochi E; Makita M; Yamamura S; Fukuoka E; Terada K; School of Pharmaceutical Sciences, Toho University, Chiba, Japan.; A heat conduction microcalorimeter was used to evaluate the isothermal transition in water from anhydrate to monohydrate at 298 K. Sulfaguanidine (SGN) anhydrate was used as a model compound for the measurement of hydration kinetics in water. It is the well-known that SGN is very slightly soluble in water and capable
Synthesis of peptides mimicking chemokine receptor CCR5 and their inhibitory effects against HIV-1 infection.: Chem Pharm Bull (Tokyo). 2000 Feb;48(2):308-9. Unique Identifier : AIDSLINE MED/20169708; Konishi K; Ikeda K; Achiwa K; Hoshino H; Tanaka K; School of Pharmaceutical Sciences, University of Shizuoka, Japan.; Peptides mimicking chemokine receptor CCR5 were synthesized and their anti-HIV-1 activities evaluated. Prepared compounds, especially a sulfated derivatives, showed significant anti-HIV-1 activities. Furthermore, a hybrid molecule linked to an N-carbomethoxycarbonyl-prolyl-phenylalanine (CPF) moiety had a greater effe
Approaches to the design of effective HIV-1 protease inhibitors.: Curr Med Chem. 2000 Apr;7(4):455-77. Unique Identifier : AIDSLINE MED/20169479; Lebon F; Ledecq M; Laboratoire de Chimie Moleculaire Structurale, Facultes; Universitaires Notre-Dame de la Paix, 61 rue de Bruxelles, Namur,; B-5000, Belgium. florence.lebon@fundp.ac.be; Recently, western countries have recorded a decrease in the death rate imputed to AIDS. This success has been largely attributed to the presence on the market of chemotherapies that inhibit the infectivity of the predominant causative agent, the HIV-1 virus, by targeting essential viral enzymes. One of these is the pr
Gossypol: prototype of inhibitors targeted to dinucleotide folds.: Curr Med Chem. 2000 Apr;7(4):479-98. Unique Identifier : AIDSLINE MED/20169480; Vander Jagt DL; Deck LM; Royer RE; Department of Biochemistry and Molecular Biology, University of; New Mexico School of Medicine, Albuquerque, NM 87131, USA.; DLVanderjagt@salud.unm.edu; Gossypol, a disesquiterpene from cottonseed, exhibits multiple biological properties, including male antifertility activity and anticancer activity. Gossypol also inhibits the growth of numerous parasitic organisms and shows antiviral activity against a number of enveloped viruses, including the AIDS virus. Derivative
Volunteer bias in nonrandomized evaluations of the efficacy of needle-exchange programs.: J Urban Health. 2000 Mar;77(1):103-12. Unique Identifier : AIDSLINE MED/20203890; Hagan H; McGough JP; Thiede H; Hopkins SG; Weiss NS; Alexander ER; Public Health-Seattle and King County, WA 98104, USA.; holly.hagan@metrokc.gov; OBJECTIVE: Nonrandomized comparisons of the incidence of HIV and hepatitis B and C between injection drug users (IDUs) who do and do not attend voluntary needle-exchange programs may be subject to bias. To explore possible sources of bias, we examined characteristics associated with voluntarily beginning or ceasing to
Antibodies to CD4 in primary Sjogren's syndrome.: Rheumatology (Oxford). 2000 Feb;39(2):142-7. Unique Identifier : AIDSLINE MED/20190039; Henriksson G; Manthorpe R; Bredberg A; Department of Medical Microbiology, University Hospital, Malmo; and. Sjogren's Syndrome Research Centre, Department of; Rheumatology, University Hospital, Malmo, Sweden.; OBJECTIVE: The purpose of this study was to examine whether antibodies against CD4 are present in patients with primary Sjogren s syndrome, and to explore the pos