2000

Partial restoration of hair growth in the DEBR model for Alopecia areata after in vivo depletion of CD4+ T cells.: Br J Dermatol. 1999 Mar;140(3):432-7. Unique Identifier : AIDSLINE MED/99249991; McElwee KJ; Spiers EM; Oliver RF; Department of Biological Sciences, University of Dundee, Dundee,; DD1 4HN, U.K.; Alopecia areata (AA) is widely believed to be an autoimmune disease. Hair loss is associated with a peri- and intrafollicular inflammatory infiltrate of anagen hair follicles primarily composed of CD4 + and CD8 + cells. A previous investigation involved in vivo depletion of CD8 + cells in the DEBR rat model to examine
Tinea capitis in two black african adults with HIV infection.: Br J Dermatol. 1999 Apr;140(4):722-4. Unique Identifier : AIDSLINE MED/99250062; Lateur N; Andre J; De Maubeuge J; Poncin M; Song M; Department of Dermatology, CHU Saint Pierre,Free University of; Brussels, 129 Boulevard de Waterloo, 1000 Bruxelles, Belgium.; Tinea capitis is rare in adults, although a few cases have been described in HIV-infected patients. We present two cases in black African adults who were HIV positive. In one, the condition led to the diagnosis of HIV infection. It is possible that the rarity of tinea capitis in HIV-positive adults could be related to
Trichophyton tonsurans dermatophyte granuloma in an HIV-1 infected patient [letter]: Br J Dermatol. 1999 Apr;140(4):762-3. Unique Identifier : AIDSLINE MED/99250077; Hadacek BM; Nassif A; Roux A; Desplaces N; Huerre M; De Bievre C; Aerts J; Raguin G
Purified protein derivative treatment for skin lesions of adult T-cell leukaemia/lymphoma [letter]: Br J Dermatol. 1999 Apr;140(4):767-8. Unique Identifier : AIDSLINE MED/99250081; Kanekura T; Gushi A; Kanzaki T
Good or evil: CD26 and HIV infection.: J Dermatol Sci. 2000 Apr;22(3):152-60. Unique Identifier : AIDSLINE MED/20161978; Ohtsuki T; Tsuda H; Morimoto C; Department of Clinical Immunology and AIDS Research Center, The; Institute of Medical Science, The University of Tokyo, Japan.; Acquired immune deficiency syndrome (AIDS) is an incurable disease at present and so many efforts to conquer this disease are being made around the world. In studies of human immunodeficiency virus (HIV) infection and the disease progression, it has been reported that T cells expressing CD26 are preferentially infecte
HHV-6, 7 and their related diseases.: J Dermatol Sci. 2000 Apr;22(3):205-12. Unique Identifier : AIDSLINE MED/20161983; Kosuge H; Department of Dermatology, Tokyo Electric Power Hospital, Japan.; haruhiko.kosuge@psl.ap-hop-paris.fr; Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are relatively recently discovered beta-herpesvirus. They are prevalent in the human population. Primary infection of HHV-6 has been associated with exanthem subitum and febrile illness. Little information is known about the clinical characteristics of primar
Uveitis in HIV positive patients [editorial]: Br J Ophthalmol. 2000 Mar;84(3):233-5. Unique Identifier : AIDSLINE MED/20149948; Cunningham ET Jr
Development of a self-inactivating, minimal lentivirus vector based on simian immunodeficiency virus.: Unique Identifier : AIDSLINE MED/20160191; Schnell T; Foley P; Wirth M; Munch J; Uberla K; In contrast to oncoviruses, lentiviruses do not require target cell division for integration into the host genome. Lentiviral vectors can therefore expand the spectrum of target cells susceptible to retroviral gene transfer. To analyze whether vectors based on simian immunodeficiency viruses (SIVs) could be used for g
Determination of indinavir, potassium sorbate, methylparaben, and propylparaben in aqueous pediatric suspensions.: J Pharm Biomed Anal. 1999 Apr;19(5):725-35. Unique Identifier : AIDSLINE MED/20162362; Kreuz DM; Howard AL; Ip D; Department of Pharmaceutical Analysis and Control, Merck Research; Laboratories, West Point, PA 19486, USA.; A gradient, reversed phase, HPLC method was developed for simultaneous analysis of potassium sorbate, methylparaben, propylparaben, and indinavir in aqueous suspensions that contain a proprietary orange flavoring and Magnasweet sweetener enhancer (Mac
Prevention, politics, and "having sex" [editorial]: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):15-6. Unique Identifier : AIDSLINE MED/20172683; Bradley-Springer L
Exploring the complexity of sleep disturbances in persons with HIV/AIDS.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):22-9. Unique Identifier : AIDSLINE MED/20172684; Nokes KM; Chidekel JH; Kendrew J; CUNY-Hunter College, Hunter-Bellevue School of Nursing, USA.; Sleep disturbances are influenced by physiological, psychological, and environmental factors. Many persons living with HIV/AIDS manifest a variety of sleep disorders. Although completion of a brief sleep assessment can be helpful to determine the presence of a sleep problem, more in-depth investigation is necessary wh
Nurse practitioners in rural California and AIDS.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):39-42. Unique Identifier : AIDSLINE MED/20172685; Lewis CE; Miramontes H; University of California-Los Angeles, USA.; A random sample of nurse practitioners located in the 26 rural counties of California were surveyed to assess their experience with HIV-positive patients. Of those selected, 70.5% participated; of those interviewed, 65.5% had seen a patient with HIV infection in the past 12 months. Of those providing primary care, 85%
Treatment of fungal infections with ABLC in the home-care setting.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):43-52. Unique Identifier : AIDSLINE MED/20172686; Weissmann AC; Invasive fungal infections are an important cause of morbidity and mortality in HIV-infected individuals. The management of opportunistic infections in a home-care setting offers many psychological and economic advantages over hospitalization. Amphotericin B, the gold standard treatment for invasive fungal infections,
Most frequently used alternative and complementary therapies and activities by participants in the AMCOA study.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):60-73. Unique Identifier : AIDSLINE MED/20172687; Greene KB; Berger J; Reeves C; Moffat A; Standish LJ; Calabrese C; Bastyr University AIDS Research Center, USA.; This literature review examines the current state of the scientific evidence published in peer-reviewed journals indexed in MedLine for the 10 most commonly noted alternative activities reported by the first 1,016 eligible participants in the Alternative Medical Care Outcomes in AIDS study. The most frequently used ac
The relationship between social support and health in gay men with HIV/AIDS: an integrative review.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):74-86. Unique Identifier : AIDSLINE MED/20172688; Hall VP; Western Carolina University, USA.; The purpose of this article is to analyze the existing research on the relationship between social support and health in gay men with HIV/AIDS. After literature review, 24 studies that met inclusion criteria were analyzed. It was found that the research could be divided into three distinct groups: (a) those studies th
Hemophilia: a story of success--disaster and the perseverance of the human spirit. Part 1: Background and overview.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):90-3. Unique Identifier : AIDSLINE MED/20172689; Dubin CS
Science is objective; isn't it?: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):94-6. Unique Identifier : AIDSLINE MED/20172690; Sharts-Hopko NC; College of Nursing, Villanova University, PA 19085-1690, USA.
Post-exposure prophylaxis of occupational exposure to HIV infection.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):97. Unique Identifier : AIDSLINE MED/20172691
Support for vaccine development in primary HIV prevention.: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):97-8. Unique Identifier : AIDSLINE MED/20172692
The impact of religion on adherence with antiretrovirals [letter]: J Assoc Nurses AIDS Care. 1999 May-Jun;10(3):99-100. Unique Identifier : AIDSLINE MED/20172693; Melbourne KM
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.: Blood. 2000 Mar 1;95(5):1680-6. Unique Identifier : AIDSLINE MED/20156002; Taylor FB Jr; Stearns-Kurosawa DJ; Kurosawa S; Ferrell G; Chang AC; Laszik Z; Kosanke S; Peer G; Esmon CT; Oklahoma Medical Research Foundation (OMRF), Oklahoma City 73104,; USA. marie.brewer@omrf.ouhsc.edu; The influence of the endothelial protein C receptor (EPCR) on the host response to Escherichia coli was studied. Animals were treated with 4 separate protocols for survival studies and analysis of physiologic and biochemical parameters: (1) monoclonal antibody (mAb) that blocks protein C/activated protein C binding to
Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality.: Blood. 2000 Mar 1;95(5):1743-51. Unique Identifier : AIDSLINE MED/20156011; Soudeyns H; Campi G; Rizzardi GP; Lenge C; Demarest JF; Tambussi G; Lazzarin A; Kaufmann D; Casorati G; Corey L; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Division of Infectious; Diseases, Department of Internal Medicine, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.; Major T-cell receptor beta chain variable region (TCRBV) repertoire perturbations are temporally associated with the down-regulation of viremia during primary human immunodeficiency virus (HIV) infection and with oligoclonal expansion and clonal exhaustion of HIV-specific cytotoxic T lymphocytes (CTLs). To determine w
Alloantigen-induced anti-HIV activity occurs prior to reverse transcription and can be generated by leukocytes from HIV-infected individuals [letter]: Blood. 2000 Mar 1;95(5):1875-6. Unique Identifier : AIDSLINE MED/20203361; Pinto LA; Blazevic V; Shearer GM; Patterson BK; Dolan MJ
Fatty acid composition of plasma lipids in HIV-infected children. Comparison with seroreverters.: Acta Paediatr. 2000 Feb;89(2):172-6. Unique Identifier : AIDSLINE MED/20173120; Agostoni C; Riva E; Esposito S; Ferraris G; Principi N; Zuccotti GV; Pediatric Department V, University of Milan, Italy.; agostoc@tin.it; Children infected with the type-1 human immunodeficiency virus (HIV) are at risk of nutritional deficiencies leading to an impaired polyunsaturated fatty acid (PUFA) status. The aim of the present study was to compare the PUFA composition of plasma lipid classes (total lipids, phospholipids (PL), cholesteryl esters (C
Intensive nursing care of kwashiorkor in Malawi [see comments]: Acta Paediatr. 2000 Feb;89(2):203-7. Unique Identifier : AIDSLINE MED/20173126; Manary MJ; Brewster DR; Department of Paediatrics, College of Medicine, University of; Malawi. MANARY@kids.wustl.edu; The case fatality rate for children with kwashiorkor in central hospitals in Malawi was 30.5% (275/901) in 1995. The purpose of this study was to determine whether improved case management with intensive nursing care could lower this case fatality rate. A total of 75 children admit
Drug company bosses jailed for selling HIV infected products [news]: BMJ. 2000 Mar 4;320(7235):601. Unique Identifier : AIDSLINE MED/20164234; Lamar J
HTLV-I/II associated disease in England and Wales, 1993-7: retrospective review of serology requests.: BMJ. 2000 Mar 4;320(7235):611-2. Unique Identifier : AIDSLINE MED/20164242; Tosswill JH; Taylor GP; Tedder RS; Mortimer PP; Virus Reference Division, Central Public Health Laboratory,; London NW9 5HT.
Prevalence of antibodies to HTLV in blood donors in north London [letter]: BMJ. 2000 Mar 4;320(7235):650. Unique Identifier : AIDSLINE MED/20164265; Barbara J; Moore MC; Hewitt PE
Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient.: Leuk Lymphoma. 1999 Oct;35(3-4):379-87. Unique Identifier : AIDSLINE GENBANK/AF042372; Morand P; Buisson M; Collandre H; Chanzy B; Genoulaz O; Bourgeat MJ; Pinel N; Leclercq P; Leroux D; Marechal V; Fritsch L; Ruigrok R; Seigneurin JM; Laboratoire de Virologie Medicale Moleculaire (RHAP), Grenoble,; France. Patrice.Morand@ujf-grenoble.fr; Human Herpesvirus 8 (HHV-8) has been consistently associated with Primary Effusion Lymphoma (PEL or body-cavity-based lymphoma) but not with other lymphomas. This paper reports on an AIDS patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where HHV-8 and Epstein-Barr virus (EBV)
Reconciling quality measurement with financial risk adjustment in health plans.: Jt Comm J Qual Improv. 2000 Mar;26(3):137-46. Unique Identifier : AIDSLINE MED/20173923; Dudley RA; Bowers LV; Luft HS; Department of Medicine, University of California, San Francisco; 94118, USA. adudley@itsa.uscf.edu; BACKGROUND: Initiatives to improve quality measurement (QM) and to create systems for financial risk adjustment (RA) have developed in response to concerns about price competition s threat to quality and stimulation of risk selection. QM is designed to help purchasers identify best plans, to aid plans in their selecti
Efficient gene transfer and expression in islets by an adenoviral vector that lacks all viral genes.: Cell Transplant. 1999 Nov-Dec;8(6):661-71. Unique Identifier : AIDSLINE MED/20163430; Guo Z; Shen J; Mital D; Hong Y; Alemany R; Zhong WW; Jensik SC; Williams JW; Department of General Surgery, Rush-Presbyterian-St. Lukes's; Medical Center, Chicago, IL 60612, USA. zhiguang@tc.umn.edu; Although adenoviral vector-mediated gene transfer has significant potential for gene therapy, host immune responses to virally expressed proteins and small insert capacity may limit its clinical application. In order to overcome these disadvantages, a new adenoviral vector that lacks all viral genes has been developed
Spontaneous carotid artery aneurysms.: Br J Surg. 2000 Feb;87(2):186-90. Unique Identifier : AIDSLINE MED/20137844; Nair R; Robbs JV; Naidoo NG; Metropolitan Vascular Service, Department of Surgery, University; of Natal, Durban, South Africa.; BACKGROUND: Spontaneous carotid artery aneurysms are infrequently reported, and are almost always non-atherosclerotic. METHODS: The records of 29 patients with a spontaneous carotid aneurysm treated in an academic vascular unit between 1990 and 1998 were reviewed. RESULTS: All 29 patients were black South Africans; th
Unison's campaign to prevent needlestick injuries.: Community Nurse. 1999 Oct;5(9):35. Unique Identifier : AIDSLINE MED/20197125; Pinkney J
Dilemmas in conducting qualitative sex research in applied field settings [see comments]: Health Educ Behav. 2000 Feb;27(1):10-23. Unique Identifier : AIDSLINE MED/20173023; Seal DW; Bloom FR; Somlai AM; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53202, USA. dseal@mcw.edu; Although resources are available to inform researchers of the many technical skills necessary to conduct qualitative research, individuals working in applied field settings often encounter ethical, moral, and sociopolitical dilemmas that cannot be resolved through the application of technical skills. The purpose of th
Induction of a germinal center phenotype in B cells in vitro by a Th2 cell line.: Cell Immunol. 1999 Dec 15;198(2):77-86. Unique Identifier : AIDSLINE MED/20115380; Morafo V; Rath S; Thomas ML; Durdik JM; Department of Biological Sciences, University of Arkansas,; Fayetteville, Arkansas 72701, USA.; We have investigated the contribution of various stimuli for generating in vitro the changes in surface phenotype characteristic of B cells responding to a T-dependent antigen in a germinal center (GC). We show that, unlike many other stimuli such as B cell mitogens, cytokines, and surrogate antigen, alone or in combi
Shedding of soluble receptor for tumor necrosis factor alpha induced by M. leprae or LPS from human mononuclear cells.: Nihon Hansenbyo Gakkai Zasshi. 1999 Nov;68(3):185-93. Unique Identifier : AIDSLINE MED/20124839; Santos DO; Lorre K; de Boer M; Van Heuverswyn H; Department of Cellular and Molecular Biology, University Federal; Fluminense, Niteroi, Brasil.; Cell surface expression and release of the tumor necrosis factor receptor (TNFR type I) was analyzed after stimulation of peripheral blood mononuclear cells (PBMC) with Mycobacterium leprae (M. leprae) or lipopolysaccharide (LPS). A transient spontaneous expression of TNFR type I on the surface of PBMC was observed. T
Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients.: J Biochem Mol Toxicol. 2000;14(3):140-7. Unique Identifier : AIDSLINE MED/20174771; Teo SK; Sabourin PJ; O'Brien K; Kook KA; Thomas SD; Celgene Corporation, Warren, NJ 07059, USA. steo@celgene.com; Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we examined the extent of thalidomide metabolism by preparations of pooled human microsomes, microsomes containing cloned human CYP isozymes (CYPIA2, CYP2A6, CYP2B6, CY
Lung-specific immune response in tuberculosis.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S11-7. Unique Identifier : AIDSLINE MED/20150851; Condos R; Rom WN; Weiden M; New York University School of Medicine, Department of Medicine,; Division of Pulmonary and Critical Care, Bellevue Chest Service,; New York, New York 10016, USA. condor01@mcgc16.med.nyu.edu
Global AIDS 1981-1999: the response.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S24-33. Unique Identifier : AIDSLINE MED/20150853; Slutkin G; Epidemiology and International Health, School of Public Health,; University of Illinois at Chicago, 60612, USA. gslutkin@uic.edu
Use of clinical risk assessments in evaluation of nucleic acid amplification tests for HIV/tuberculosis.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S34-40. Unique Identifier : AIDSLINE MED/20150854; Perry S; Catanzaro A; Department of Medicine, Division of Pulmonary and Critical Care,; University of California, San Diego, USA.
Molecular determinants of drug resistance in tuberculosis.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S4-10. Unique Identifier : AIDSLINE MED/20150850; Riska PF; Jacobs WR Jr; Alland D; State University of New York-Health Science Center at Brooklyn,; New York, USA.; Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-bas
Applying advances to the clinic and health care delivery: putting the strategies to work.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S41-4. Unique Identifier : AIDSLINE MED/20150855; Ashkar BE; Consultation Services, County of Los Angeles Department of Health; Services Tuberculosis Control Program, California 90007, USA.; bashkar699@aol.com
Community responses to HIV/TB in Canada: a discussion of issues addressed in the HIV/TB Project of the Canadian AIDS Society.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S49-54. Unique Identifier : AIDSLINE MED/20150857; Zack E; Canadian Working Group on HIV Rehabilitation, Toronto.; ezack@interlog.com
Applying advances to the developing world for TB and HIV control.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S65-70. Unique Identifier : AIDSLINE MED/20150860; Harries AD; Foundation Professor of Medicine, College of Medicine, Malawi,; Technical Advisor, Malawi National Tuberculosis Programme,; Lilongwe. adharries@malawi.net
The impact of drug resistance on the global tuberculosis epidemic.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S71-5. Unique Identifier : AIDSLINE MED/20150861; Schluger NW; The Division of Pulmonary, Allergy, and Critical Care Medicine,; Columbia University College of Physicians and Surgeons, New York,; New York 10032, USA. ns311@columbia.edu
Tuberculosis preventive therapy for HIV-infected persons in less developed countries.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S76-81. Unique Identifier : AIDSLINE MED/20150862; Kritski AL; Unidade de Pesquisa em Tuberculose, Servico de Pneumologia,; Hospital Universitario Clementino Fraga Filho/Universidade; Federal do Rio de Janeiro (HUCFF/UFRJ), Brazil.; akritski@infolink.com.br
Translating discoveries into control of tuberculosis in HIV-infected persons.: Int J Tuberc Lung Dis. 2000 Feb;4(2 Suppl 1):S82-7. Unique Identifier : AIDSLINE MED/20150863; Hopewell PC; University of California, San Francisco, California 94110, USA.; phopewel@sfghdean.ucsf.edu
The availability of local and affordable treatments for AIDS in Sub-Saharan Africa.: J Altern Complement Med. 1999 Dec;5(6):505-7. Unique Identifier : AIDSLINE MED/20094040; Homsy J; Traditional and Modern Health Practitioners Together Against; AIDS, Kampala, Uganda. jaco@capp.ch
Evaluating herbal medicine for the management of Herpes zoster in human immunodeficiency virus-infected patients in Kampala, Uganda.: J Altern Complement Med. 1999 Dec;5(6):553-65. Unique Identifier : AIDSLINE MED/20094045; Homsy J; Katabira E; Kabatesi D; Mubiru F; Kwamya L; Tusaba C; Kasolo S; Mwebe D; Ssentamu L; Okello M; King R; Traditional and Modern Health Practitioners Together Against AIDS; (THETA), Kampala, Uganda.; OBJECTIVE: This study was carried out to evaluate the potential effectiveness of herbal treatments used for herpes zoster (HZ) by a great number of people living with acquired immunodeficiency syndrome (PLWAs) in Uganda . SETTING: Kampala, Uganda. Clinics of indigenous traditional h
Nutrients and HIV: part two--vitamins A and E, zinc, B-vitamins, and magnesium.: Altern Med Rev. 2000 Feb;5(1):39-51. Unique Identifier : AIDSLINE MED/20161034; Patrick L; There is compelling evidence that micronutrient deficiencies can profoundly affect immunity; micronutrient deficiencies are widely seen in HIV, even in asymptomatic patients. Direct relationships have been found between deficiencies of specific nutrients, such as vitamins A and B12, and a decline in CD4 counts. Defici
Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):235-8. Unique Identifier : AIDSLINE MED/20162269; Singh SB; Felock P; Hazuda DJ; Natural Products Drug Discovery, Merck Research Laboratories,; Rahway, NJ 07065, USA. sheo_singh@merck.com; Integric acid (1), an acyl eremophilane sesquiterpenoid, was identified as an inhibitor of HIV-1 integrase, the enzyme responsible for provirus entry into the host cell nucleus and integration in to the host genome. Chemical and enzymatic modification of integric acid led to the preparation of several selective chemic
Recognition and inhibition of HIV integrase by a novel dinucleotide.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):249-51. Unique Identifier : AIDSLINE MED/20162272; Taktakishvili M; Neamati N; Pommier Y; Nair V; Department of Chemistry, The University of Iowa, Iowa City 52242,; USA.; The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually
1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole: a potent lead for the design of novel NNRTIs.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):253-6. Unique Identifier : AIDSLINE MED/20162273; Silvestri R; Artico M; Massa S; Marceddu T; De Montis F; La Colla P; Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di; Studi Farmaceutici, Universita di Roma La Sapienza, Rome, Italy.; A novel family of non-nucleoside reverse transcriptase inhibitors (NNRTIs) active at submicromolar concentrations was discovered. The new derivatives are 1-[2-(diarylmethoxy)ethyl]imidazoles bearing substituents both at benzene and imidazole rings. The most potent derivatives were those having nitro and methyl groups
Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.: Bioorg Med Chem Lett. 2000 Feb 7;10(3):265-8. Unique Identifier : AIDSLINE MED/20162276; Hogberg M; Engelhardt P; Vrang L; Zhang H; Medivir AB, Huddinge, Sweden. marita.hogberg@medivir.se; Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenethyl group with benzoylethyl group (compounds 11-20) have been studied. Synthesis and antiviral activities are descri
Effect of application volume of ethanol-isopropyl myristate mixed solvent system on permeation of zidovudine and probenecid through rat skin.: Drug Dev Ind Pharm. 2000 Feb;26(2):193-8. Unique Identifier : AIDSLINE MED/20162864; Jin Y; Seki T; Morimoto Y; Juni K; Research Institute of TTS Technology, Saitama, Japan.; Permeation of zidovudine ( AZT ) and probenecid from an ethanol-isopropyl myristate (IPM) mixed system through rat skin was studied in a finite system. Several volume sizes of the ethanol-IPM mixed systems containing AZT and probenecid, both as suspensi
Are women disfavoured in the estimation of disability adjusted life years and the global burden of disease?: Scand J Public Health. 1999 Dec;27(4):279-85. Unique Identifier : AIDSLINE MED/20187066; Sundby J; Section for Medical Anthropology, Institute of General Practice; and Community Medicine, University of Oslo, Norway.; Addressing women s health goes beyond merely producing gender-disaggregated data. A women s perspective on health issues involves an analysis based on knowledge of broader gender differences than those that can be attributed to biology alone. Women and men live different lives. It is therefore important to evaluate wh
Human immunodeficiency virus: post-exposure prophylaxis.: Curr Opin Urol. 1999 Jan;9(1):51-5. Unique Identifier : AIDSLINE MED/20190271; Parschalk B; Pernerstorfer-Schon H; Department for Infectious Diseases, Internal Medicine I,; University Hospital of Vienna, Austria.; Post-exposure prevention is a combined modality approach to reducing HIV transmission. The recommendations are based on the risk of local prevalence and on the likelihood of transmission. In the light of the severe consequences of HIV infection, post-exposure prophylaxis after occupational exposure should be recommend
1st International Conference on the Discovery and Clinical Development of Antiretroviral Therapies. St. Thomas, West Indies, US Virgin Islands. 13-17 December 1998. Abstracts.: Antivir Ther. 1998;3 Suppl 5:3-99. Unique Identifier : AIDSLINE MED/20196710
Blockage of HIV-1 production through inhibition of proviral DNA synthesis by N,O-didecanoyl serinal dimethylacetal.: IUBMB Life. 1999 Sep;48(3):311-5. Unique Identifier : AIDSLINE MED/20155234; Takamune N; Misumi S; Furuishi K; Shoji S; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Kumamoto University, Japan.; Six serinal derivatives were synthesized and tested for their anti-human immunodeficiency virus type-1 (HIV-1) activity against HIV-1-infected cells. Of the 6 serinal derivatives tested, only N,O-didecanoyl serinal dimethylacetal (DDSD) was found to strongly suppress progeny virus production from acute HIV-1-infected
Significance of detecting Epstein-Barr-specific sequences in the peripheral blood of asymptomatic pediatric liver transplant recipients.: Liver Transpl. 2000 Jan;6(1):62-6. Unique Identifier : AIDSLINE MED/20167469; Krieger NR; Martinez OM; Krams SM; Cox K; So S; Esquivel CO; Stanford University Medical Center, Stanford, CA 94304-1510, USA.; Pediatric allograft recipients are at increased risk for Epstein-Barr virus (EBV)-associated illnesses. The early identification and diagnosis of EBV-associated disorders is critical because disease progression can often be curtailed by modification of immunosuppression. We have previously shown that detection of EBV-
Cognitive-behavioral stress management increases free testosterone and decreases psychological distress in HIV-seropositive men.: Health Psychol. 2000 Jan;19(1):12-20. Unique Identifier : AIDSLINE MED/20174725; Cruess DG; Antoni MH; Schneiderman N; Ironson G; McCabe P; Fernandez JB; Cruess SE; Klimas N; Kumar M; Department of Psychology, University of Miami, Coral Gables,; Florida 33124-2070, USA.; The effects of a 10-week group-based cognitive-behavioral stress management (CBSM) intervention on psychological distress and plasma free testosterone in symptomatic, HIV-seropositive men were examined. Participants were randomized to either CBSM (n = 42) or a wait-list control group (n = 23). Men in the CBSM interven
Using information, motivational enhancement, and skills training to reduce the risk of HIV infection for low-income urban women: a second randomized clinical trial.: Health Psychol. 2000 Jan;19(1):3-11. Unique Identifier : AIDSLINE MED/20174724; Carey MP; Braaten LS; Maisto SA; Gleason JR; Forsyth AD; Durant LE; Jaworski BC; Department of Psychology, Center for Health and Behavior,; Syracuse University, New York 13244-2340, USA. mpcarey@syr.edu; This randomized clinical trial evaluated an HIV-risk reduction (HIV-RR) intervention based on the information-motivation-behavioral skills model. At baseline, 102 women (M age = 29 years; 88% African American) completed a survey regarding HIV-related knowledge, risk perceptions, behavioral intentions, and risk behavio
Prevalence of serum antibodies against bloodborne and sexually transmitted agents in selected groups in Somalia.: Epidemiol Infect. 2000 Feb;124(1):137-41. Unique Identifier : AIDSLINE MED/20185216; Nur YA; Groen J; Elmi AM; Ott A; Osterhaus AD; Institute of Virology, WHO Collaborating Center of Arboviruses; and Haemorrhagic Fever viruses, Reference and Research,; University Hospital Rotterdam, The Netherlands.; Somalia has suffered from a civil war during the last 10 years. In this period the use of whole blood has increased at least twofold in Mogadishu, Somalia compared with pre-war. Screening possibilities are limited. Recent data concerning the prevalence of infections with blood-bor
Cross-sectional study on risk factors of HIV among female commercial sex workers in Cambodia.: Unique Identifier : AIDSLINE MED/20185217; Ohshige K; Morio S; Mizushima S; Kitamura K; Tajima K; Ito A; Suyama A; Usuku S; Saphonn V; Heng S; Hor LB; Tia P; Soda K; Department of Public Health, Yokohama City University, School of; Medicine, Japan.; To describe epidemiological features on HIV prevalence among female commercial sex workers (CSWs), a cross-sectional study on sexual behaviour and serological prevalence was carried out in Cambodia . The CSWs were interviewed on their demographic characters and behaviour and their
Risk factors for pulmonary disease due to culture-positive M. tuberculosis or nontuberculous mycobacteria in South African gold miners.: Eur Respir J. 2000 Feb;15(2):291-6. Unique Identifier : AIDSLINE MED/20169011; Sonnenberg P; Murray J; Glynn JR; Thomas RG; Godfrey-Faussett P; Shearer S; Dept of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.; The aim of this study was to determine risk factors for disease due to nontuberculous mycobacteria (NTM) compared to those due to Mycobacterium tuberculosis in South African gold miners with pulmonary mycobacterial disease. A case/control study comparing tuberculosis and NTM cases amongst all patients with a positive
Tuberculosis among health care workers during three recent decades.: Eur Respir J. 2000 Feb;15(2):304-7. Unique Identifier : AIDSLINE MED/20169013; Raitio M; Tala E; Dept of Chest Diseases, Turku University Central Hospital,; Finland.; Some studies have found that health care workers have an increased risk of tuberculosis, whereas other studies have reported the opposite. This study examined data of Finnish health care workers (HCWs) for the incidence of tuberculosis disease. Cases of occupational tuberculosis in
Voices from the clinic: AIDS then and now.: Health Aff (Millwood). 2000 Mar-Apr;19(2):191-7. Unique Identifier : AIDSLINE MED/20182496; Zuger A
[Correlations of T lymphocyte subsets and IL-2, sIL-2R in patients with malignant ovarian tumor]: Hua Hsi I Ko Ta Hsueh Hsueh Pao. 1997 Jun;28(2):210-3. Unique Identifier : AIDSLINE MED/20147561; Wang H; Peng Z; Zhang C; Department of Obstetrics and Gynecology, Second Affiliated; Hospital, Chengdu.; To study the relation between malignant ovarian tumor (MOT) and cell mediated immunity, the numbers of T lymphocyte subsets and levels of IL-2 and sIL-2R were measured simultaneously in 40 patients with MOT and 30 normal controls (NC), and the correlations between T su
Epitope-vaccine induces high levels of ELDKWA-epitope-specific neutralizing antibody.: Immunol Invest. 2000 Feb;29(1):41-50. Unique Identifier : AIDSLINE MED/20173079; Xiao Y; Zhao Y; Lu Y; Chen YH; Laboratory of Immunology, Research Centre for Medical Science and; the School of Life Science and Engineering, Tsinghua University,; Beijing, P.R. China.; Based on the fact that mAb 2F5 recognizing ELDKWA-epitope on the C-domain of HIV-1 gp41 has significant neutralization potency against 90% of the investigated viruses of African, Asian, American and European strains, we attempted to characterise immunogenicity of the ELDKWA-epitope on an epitope-vaccine, and to produc
The impact of HIV on meningitis as seen at a South African Academic Hospital (1994 to 1998).: Infection. 2000 Jan-Feb;28(1):3-7. Unique Identifier : AIDSLINE MED/20162891; Schutte CM; Van der Meyden CH; Magazi DS; Dept. of Neurology, University of Pretoria, South Africa.; cschutte@medic.up.ac.za; BACKGROUND: The increase in HIV infections in South Africa is alarming. The aim of this prospective 4-year study was to evaluate the rising incidence of HIV-related admissions due to meningitis at the Pretoria Academic Hospital (PAH) adult neurology ward and to investigate the spe
Specific in vitro proliferative immune responses and lymphokine production in Ethiopian children with and without tuberculosis.: Infection. 2000 Jan-Feb;28(1):42-5. Unique Identifier : AIDSLINE MED/20162899; Kori M; Barak V; Leibovitz E; Altman Y; Eliraz A; Handzel ZT; Kaplan Hospital, Kaplan Medical Center, Rehovot, Israel.; We investigated the profile of some in vitro parameters of cellular immune responses in non-HIV-infected Ethiopian children and young adults with and without tuberculosis (TB) as compared to healthy Ethiopian and non-Ethiopian controls. The in vitro proliferative responses of peripheral blood mononuclear cells (PBMC)
Is interruption of HIV therapy always harmful?: J Antimicrob Chemother. 2000 Feb;45(2):137-8. Unique Identifier : AIDSLINE MED/20127813; Youle M; Royal Free Centre for HIV Medicine, Royal Free Hospital, Pond; Street, London NW3 2QG, UK.
In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy.: J Antimicrob Chemother. 2000 Feb;45(2):239-42. Unique Identifier : AIDSLINE MED/20127829; Rodero L; Cordoba S; Cahn P; Hochenfellner F; Davel G; Canteros C; Kaufman S; Guelfand L; Departamento Micologia, Instituto Nacional de Enfermedades; Infecciosas, ANLIS 'Dr Carlos G. Malbran', Av. Velez Sarsfield; 563, 1281 Buenos Aires, Argentina. lrodero@mail.retina.ar; The in vitro activities of three antifungal drugs alone and in combination were evaluated against five isolates of Cryptococcus neoformans using time-kill curves (TKC). The isolates were from AIDS patients who had either died or had failed to show a clinical response during amphotericin B (AMB) treatment. AMB, flucona
Substitution of protease inhibitors during treatment of patients with human immunodeficiency virus infection: frequency, mode, reasons and mid-term outcome [letter]: J Antimicrob Chemother. 2000 Feb;45(2):261-3. Unique Identifier : AIDSLINE MED/20127836; Manfredi R; Chiodo F
Evolution of drug resistance in experimental populations of Candida albicans.: J Bacteriol. 2000 Mar;182(6):1515-22. Unique Identifier : AIDSLINE MED/20158866; Cowen LE; Sanglard D; Calabrese D; Sirjusingh C; Anderson JB; Kohn LM; Department of Botany, University of Toronto, Mississauga,; Ontario, Canada L5L 1C6. lcowen@credit.erin.utoronto.ca; Adaptation to inhibitory concentrations of the antifungal agent fluconazole was monitored in replicated experimental populations founded from a single, drug-sensitive cell of the yeast Candida albicans and reared over 330 generations. The concentration of fluconazole was maintained at twice the MIC in six populations;
Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150.: J Biochem (Tokyo). 1999 Dec;126(6):1033-42. Unique Identifier : AIDSLINE GENBANK/AA556203; Shimada M; Saito M; Katakai T; Shimizu A; Ichimura T; Omata S; Horigome T; Course of Advanced Material Science, Graduate School of Science; and Technology, Niigata University, 2-Igarashi, Niigata,; 950-2181, Japan.; We previously characterized p144 bearing N-acetylglucosamine residues in a rat liver nuclear matrix fraction. Based on partial amino acid sequences of rat p144, mouse p144 cDNA was cloned and sequenced, and its amino acid sequence was predicted. The sequence revealed that p144 is a rat homologue of CA150, which is a t
Human vascular smooth muscle cells possess functional CCR5.: J Biol Chem. 2000 Feb 25;275(8):5466-71. Unique Identifier : AIDSLINE MED/20148745; Schecter AD; Calderon TM; Berman AB; McManus CM; Fallon JT; Rossikhina M; Zhao W; Christ G; Berman JW; Taubman MB; Zena and Michael A. Wiener Cardiovascular Institute, The Mount; Sinai School of Medicine, New York, New York 10029, USA.; CC chemokine receptors are important modulators of inflammation. Although CC chemokine receptors have been found predominantly on leukocytes, recent studies have suggested that vascular smooth muscle cells respond to CC chemokines. We now report that human smooth muscle cells express CCR5, a co-receptor for human immu
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.: J Biol Chem. 2000 Feb 25;275(8):5633-9. Unique Identifier : AIDSLINE PDB/1DTTSF; Ren J; Diprose J; Warren J; Esnouf RM; Bird LE; Ikemizu S; Slater M; Milton J; Balzarini J; Stuart DI; Stammers DK; Structural Biology Division, The Wellcome Trust Centre for Human; Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN,; United Kingdom.; Most non-nucleoside reverse transcriptase (RT) inhibitors are specific for HIV-1 RT and demonstrate minimal inhibition of HIV-2 RT. However, we report that members of the phenylethylthiazolylthiourea (PETT) series of non-nucleoside reverse transcriptase inhibitors showing high potency against HIV-1 RT have varying abi
Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding.: J Cell Biochem. 2000 Feb;77(1):65-74. Unique Identifier : AIDSLINE MED/20145931; Wortman MJ; Krachmarov CP; Kim JH; Gordon RG; Chepenik LG; Brady JN; Gallia GL; Khalili K; Johnson EM; Department of Pathology and Brookdale Center for Molecular and; Developmental Biology, Mount Sinai School of Medicine, New York,; NY 10029, USA.; A complex between the Tat protein, encoded by human immunodeficiency virus type 1 (HIV-1), and the cellular protein, Puralpha, has been implicated in activation of the late promoter of JC virus (JCV) and in enhancement of JCV DNA replication. JCV is the causative agent of progressive multifocal leukoencephalopathy (PM
Factors influencing T-cell turnover in HIV-1-seropositive patients [see comments]: J Clin Invest. 2000 Mar;105(5):R1-8. Unique Identifier : AIDSLINE MED/20177756; McCune JM; Hanley MB; Cesar D; Halvorsen R; Hoh R; Schmidt D; Wieder E; Deeks S; Siler S; Neese R; Hellerstein M; The Gladstone Institute of Virology and Immunology, University of; California-San Francisco, San Francisco, California 94141, USA.; mmccune@gladstone.ucsf.edu; HIV-1 disease is associated with pathological effects on T-cell production, destruction, and distribution. Using the deuterated (2H) glucose method for endogenous labeling, we have analyzed host factors that influence T-cell turnover in HIV-1-uninfected and -infected humans. In untreated HIV-1 disease, the average hal
Normal physiology and HIV pathophysiology of human T-cell dynamics [comment]: J Clin Invest. 2000 Mar;105(5):565-6. Unique Identifier : AIDSLINE MED/20177742; Richman DD; Departments of Pathology and Medicine - 0679, San Diego Veterans; Affairs Medical Center and University of California-San Diego,; 9500 Gilman Drive, La Jolla, California 92037-0679, USA.; drichman@ucsd.edu
The role of nurses in AIDS care regarding voluntary euthanasia and assisted suicide: a call for further dialogue.: J Adv Nurs. 2000 Mar;31(3):513-9. Unique Identifier : AIDSLINE MED/20184229; Young MG; Ogden RD; Camosun College, Victoria, British Columbia, Canada; New; Westminster, British Columbia, Canada. michaely@uvic.ca; The role of nurses in AIDS care regarding voluntary euthanasia and assisted suicide: a call for further dialogue Because of the nature of their work, nurses are directly involved with terminally ill patients and the problems associated with the decision to hasten death through voluntary euthanasia or assisted suicide
German nursing students' knowledge of and attitudes to HIV and AIDS: two decades after the first AIDS cases.: J Adv Nurs. 2000 Mar;31(3):696-703. Unique Identifier : AIDSLINE MED/20184250; Lohrmann C; Valimaki M; Suominen T; Muinonen U; Dassen T; Peate I; Humboldt-Universitat, Institut fur Medizin-/Pflegepadagogik; und Pflegewissenschaft, Berlin, Germany. chrlohrmann@yahoo.com; German nursing students knowledge of and attitudes to HIV and AIDS: two decades after the first AIDS case This study describes German nursing students (n=180) knowledge and attitudes relating to HIV/AIDS, their homophobia level, willingness to care for people with AIDS, and their approach to possible sexual risk beh
HIV-infected surgical personnel under the ADA: do they pose a direct threat or are reasonable accommodations possible?: J Contemp Health Law Policy. 1999 Winter;16(1):127-46. Unique Identifier : AIDSLINE MED/20159571; Rohlfsen RJ
A national epidemic, a national conversation, a national law: in support of unique identifier reporting for HIV surveillance.: J Contemp Health Law Policy. 1999 Winter;16(1):173-209. Unique Identifier : AIDSLINE MED/20159573; Kramer KM
Post-transfusion HIV infection despite donor screening: a report of three cases.: J Hosp Infect. 2000 Feb;44(2):93-7. Unique Identifier : AIDSLINE MED/20130304; Martlew VJ; Carey P; Tong CY; Parry JV; Belda FJ; Barlow KL; Chu P; Syed Q; Department of Haematology, Royal Liverpool University Hospital.; In August 1996, a blood donation was collected which subsequently infected three patients post-transfusion with HIV 1. The donation itself was originally screened as negative for anti-HIV 1/2 using a sensitive EIA method, but subsequently was shown to contain p24 Ag and HIV RNA by an amplification technique. The propo
Risk of HIV transmission from patients to surgeons in the era of post-exposure prophylaxis.: Unique Identifier : AIDSLINE MED/20130305; Goldberg D; Johnston J; Cameron S; Fletcher C; Stewart M; McMenamin J; Codere G; Hutchinson S; Raeside F; The HIV prevalence, among patients either undergoing, or with the potential to undergo, surgery were estimated using data from unlinked anonymous HIV surveys of patients in Glasgow hospitals during 1992-1997 in order to quantify the risk of surgeons acquiring HIV occupationally in the era of post-exposure prophylaxis
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.: J Immunol. 2000 Mar 15;164(6):2861-5. Unique Identifier : AIDSLINE MED/20171480; Heath VL; Showe L; Crain C; Barrat FJ; Trinchieri G; O'Garra A; Department of Immunobiology, DNAX Research Institute, Palo Alto,; CA 94304, USA. Heath@DNAX.org; The IL-12 receptor-beta 2 (IL-12R beta 2) chain is expressed on Th1 cells and lost upon differentiation to the Th2 phenotype. This has been suggested as the basis for commitment of Th1 cells, because early differentiated Th2 cells do not reverse their phenotype and do not produce IFN-gamma on restimulation in the pres
A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells.: J Immunol. 2000 Mar 15;164(6):2890-6. Unique Identifier : AIDSLINE MED/20171484; Blanas E; Davey GM; Carbone FR; Heath WR; Walter and Eliza Hall Institute of Medical Research, Melbourne,; Victoria, Australia.; We have previously reported that feeding OVA to C57BL/6 mice can lead to a weak CTL response that is dependent on CD4+ T cell help and is capable of causing autoimmunity. In this study, we investigated the basis of the class I and class II-restricted Ag presentation required for such CTL induction. Two days after feed
CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen.: J Immunol. 2000 Mar 15;164(6):2955-63. Unique Identifier : AIDSLINE MED/20171492; Rogers PR; Croft M; Division of Immunochemistry, La Jolla Institute for Allergy and; Immunology, San Diego, CA 92121, USA.; The involvement of specific accessory/costimulatory molecules in differentiation to Th1 and Th2 phenotypes is controversial. Reports suggest that molecules such as CD4, CD28, and Ox-40 support Th2 differentiation and suppress Th1 differentiation, whereas others such as LFA-1 support Th1 responses and suppress Th2 resp
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile.: J Immunol. 2000 Mar 15;164(6):3047-55. Unique Identifier : AIDSLINE MED/20171503; Jankovic D; Kullberg MC; Noben-Trauth N; Caspar P; Paul WE; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, and; Laboratory of Immunology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA. djankovic@niaid.nih.gov; The concept that IL-4 is the primary signal for Th2 lymphocyte differentiation has recently been put in doubt by studies in which the production of Th2-associated cytokines was detected in mice deficient in IL-4 synthesis or IL-4R triggering. In this study, we formally demonstrate by single cell analysis that CD4+ lym
Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression.: J Immunol. 2000 Mar 15;164(6):3056-64. Unique Identifier : AIDSLINE MED/20171504; Yin Z; Zhang DH; Welte T; Bahtiyar G; Jung S; Liu L; Fu XY; Ray A; Craft J; Sections of Rheumatology and Pulmonary and Critical Care; Medicine, Department of Medicine, Department of Pathology, and; Section of Immunobiology, Yale School of Medicine, New Haven, CT; 06520, USA.; Gamma delta T cells secrete Th1- and Th2-like cytokines that help mediate innate and acquired immunity. We have addressed the mechanism whereby murine gamma delta T cells acquire the capacity to differentially produce such cytokines. Splenic gamma delta T cells could be polarized into IFN-gamma- or IL-4-secreting cell
Induction of diabetes in nonobese diabetic mice by Th2 T cell clones from a TCR transgenic mouse.: J Immunol. 2000 Mar 15;164(6):3072-8. Unique Identifier : AIDSLINE MED/20171506; Poulin M; Haskins K; Department of Immunology and Barbara Davis Center for Childhood; Diabetes, University of Colorado Health Sciences Center, Denver,; CO 80262, USA.; We have produced a panel of cloned T cell lines from the BDC-2.5 TCR transgenic (Tg) mouse that exhibit a Th2 cytokine phenotype in vitro but are highly diabetogenic in vivo. Unlike an earlier report in which T cells obtained from the Tg mouse were cultured for 1 wk under Th2-promoting conditions and were found to ind
CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity.: Unique Identifier : AIDSLINE MED/20171509; Hermans IF; Ritchie DS; Yang J; Roberts JM; Ronchese F; The fate of dendritic cells (DC) after they have initiated a T cell immune response is still undefined. We have monitored the migration of DC labeled with a fluorescent tracer and injected
The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine.: J Immunol. 2000 Mar 15;164(6):3102-11. Unique Identifier : AIDSLINE MED/20171510; Kusakabe K; Xin KQ; Katoh H; Sumino K; Hagiwara E; Kawamoto S; Okuda K; Miyagi Y; Aoki I; Nishioka K; Klinman D; Okuda K; Departments of Bacteriology, Internal Medicine, and Pathology,; YokohamaCity University School of Medicine, Yokohama, Japan.; The mechanism of immune activation induced by a plasmid-encoding GM-CSF (pGM-CSF), administered in combination with a DNA vaccine encoding the envelope of HIV, was studied. Injecting pGM-CSF i.m. into mice 3 days before DNA vaccination primarily induced a Th2 response. Simultaneous administration of the DNA vaccine pl
Intratumoral coinjection of two adenoviruses, one encoding the chemokine IFN-gamma-inducible protein-10 and another encoding IL-12, results in marked antitumoral synergy.: IC USE Viral Vaccines/GENETICS/*IMMUNOLOGY/THERAPEUTIC USE J Immunol. 2000 Mar 15;164(6):3112-22. Unique Identifier : AIDSLINE MED/20171511; Narvaiza I; Mazzolini G; Barajas M; Duarte M; Zaratiegui M; Qian C; Melero I; Prieto J; Departments ofMedicine and Genetics, Facultad de Medicina,; Universidad de Navarra, Pamplona, Spain.
Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes.: J Immunol. 2000 Mar 15;164(6):3236-45. Unique Identifier : AIDSLINE MED/20171526; Tellier MC; Greco G; Klotman M; Mosoian A; Cara A; Arap W; Ruoslahti E; Pasqualini R; Schnapp LM; Divisions of Pulmonary and Critical Care Medicine and Infectious; Disease, Mount Sinai School of Medicine, New York, NY 10029, USA.; The ability of viruses and bacteria to interact with the extracellular matrix plays an important role in their infectivity and pathogenicity. Fibronectin is a major component of the extracellular matrix in lymph node tissue, the main site of HIV deposition and replication during the chronic phase of infection. Therefo
CD4+ T cell priming accelerates the clearance of Sendai virus in mice, but has a negative effect on CD8+ T cell memory.: J Immunol. 2000 Mar 15;164(6):3274-82. Unique Identifier : AIDSLINE MED/20171530; Zhong W; Marshall D; Coleclough C; Woodland DL; Trudeau Institute, Saranac Lake, NY 12983, USA.; Current vaccines designed to promote humoral immunity to respiratory virus infections also induce potent CD4+ T cell memory. However, little is known about the impact of primed CD4+ T cells on the immune response to heterologous viruses that are serologically distinct, but that share CD4+ T cell epitopes. In addition,
Chemokines fail to up-regulate beta 1 integrin-dependent adhesion in human Th2 T lymphocytes.: Unique Identifier : AIDSLINE MED/20171532; Clissi B; D'Ambrosio D; Geginat J; Colantonio L; Morrot A; Freshney NW; Downward J; Sinigaglia F; Pardi R; Th1 and Th2 cells are functionally distinct subsets of CD4+ T lymphocytes whose tissue-specific homing to sites of inflammation is regulated in part by the differential expression of P- and E-selectin ligands and selected chemokine receptors. Here we investigated the expression and function of beta 1 integrins in Th1
Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: implications for tubulointerstitial injury in chronic glomerulonephritides.: J Immunol. 2000 Mar 15;164(6):3323-9. Unique Identifier : AIDSLINE MED/20171536; Kuroiwa T; Schlimgen R; Illei GG; McInnes IB; Boumpas DT; Arthritis and Rheumatism Branch, National Institute of Arthritis; and Musculoskeletal and Skin Diseases, National Institutes of; Health, Bethesda, MD 20892, USA. kuroiwat@arb.niams.nih.gov; Chemokines can promote interstitial fibrosis that is, in turn, a strong predictor of renal failure in chronic glomerulonephritides (GN). Resident renal cells, including renal tubular epithelial cells (RTEC), represent a prominent source of chemokine expression. Evaluating those factors responsible for sustained chemok
Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.: J Immunol. 2000 Mar 15;164(6):3368-76. Unique Identifier : AIDSLINE MED/20171542; Muehlhoefer A; Saubermann LJ; Gu X; Luedtke-Heckenkamp K; Xavier R; Blumberg RS; Podolsky DK; MacDermott RP; Reinecker HC; Gastrointestinal Unit, Department of Medicine, Center for the; Study of Inflammatory Bowel Disease, Massachusetts General; Hospital and Harvard Medical School, Boston, MA 02114, USA.; Fractalkine is a unique chemokine that combines properties of both chemoattractants and adhesion molecules. Fractalkine mRNA expression has been observed in the intestine. However, the role of fractalkine in the healthy intestine and during inflammatory mucosal responses is not known. Studies were undertaken to determ
In vitro priming with adenovirus/gp100 antigen-transduced dendritic cells reveals the epitope specificity of HLA-A*0201-restricted CD8+ T cells in patients with melanoma.: J Immunol. 2000 Mar 15;164(6):3402-12. Unique Identifier : AIDSLINE MED/20171546; Linette GP; Shankara S; Longerich S; Yang S; Doll R; Nicolette C; Preffer FI; Roberts BL; Haluska FG; Hematology-Oncology Unit and Department of Pathology,; Massachusetts General Hospital, Boston, MA 02114, USA.; linette.gerald@mgh.harvard.edu; Replication-deficient recombinant adenovirus (Ad) encoding human gp100 or MART-1 melanoma Ag was used to transduce human dendritic cells (DC) ex vivo as a model system for cancer vaccine therapy. A second generation E1/E4 region deleted Ad which harbors the CMV
CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitro.: J Immunol. 2000 Mar 15;164(6):3426-33. Unique Identifier : AIDSLINE MED/20171549; Lopalco L; Barassi C; Pastori C; Longhi R; Burastero SE; Tambussi G; Mazzotta F; Lazzarin A; Clerici M; Siccardi AG; Department of Biological and Technological Research and; Infectious Diseases Clinic, San Raffaele Scientific Institute,; Milano, Italy. lopalco.lucia@hsr.it; Exposure to HIV does not necessarily result in infection. Because primary HIV infection is associated with CCR5-tropic HIV variants (R5), CCR5-specific Abs in the sera of HIV-seronegative, HIV-exposed individuals (ESN) might be associated with protection against infection. We analyzed sera from ESN, their HIV-infected
HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer.: J Endocrinol. 2000 Feb;164(2):R7-R10. Unique Identifier : AIDSLINE MED/20126018; Wentworth JM; Burris TP; Chatterjee VK; Level 5, Department of Medicine, Addenbrookes, Cambridge CB2 2QQ,; UK.; A recent prospective clinical study has shown that antiviral therapy with HIV protease inhibitors (PIs) is associated with a syndrome of peripheral fat wasting (lipodystrophy) and disordered glucose and lipid metabolism (Carr et al. 1999). We have studied the effect
How does tuberculosis relate to HIV positive and HIV negative drug users?: J Epidemiol Community Health. 2000 Jan;54(1):64-8. Unique Identifier : AIDSLINE MED/20157354; Keizer ST; Langendam MM; van Deutekom H; Coutinho RA; van Ameijden EJ; Department for Tuberculosis-control, Amsterdam Municipal Health; Service, The Netherlands.; OBJECTIVES: (1) To compare the incidence of active tuberculosis in HIV positive and HIV negative drug users. (2) To describe the main characteristics of the tuberculosis cases. DESIGN: A prospective study was performed from 1986 to 1996 as part of an ongoing cohort study of HIV infection in Amsterdam drug users. METHO
Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women.: J Gen Virol. 2000 Mar;81 Pt 3:701-8. Unique Identifier : AIDSLINE MED/20141382; Petter A; Heim K; Guger M; Ciresa-Ko Nig A; Christensen N; Sarcletti M; Wieland U; Pfister H; Zangerle R; Hopfl R; Department of Dermatology, University Clinic, Anichstrabetae 35,; A-6020 Innsbruck, Austria. anton.petter@uibk.ac.at; To evaluate the humoral immune response to human papillomavirus (HPV) in women infected with human immunodeficiency virus (HIV), serum samples of 83 HIV-positive individuals were analysed by ELISA for specific antibodies of the isotypes IgG, IgA and IgM recognizing HPV-6, -11, -16, -18 and -31 L1 virus-like particles
Subterminal viral DNA nucleotides as specific recognition signals for human immunodeficiency virus type 1 and visna virus integrases under magnesium-dependent conditions.: J Gen Virol. 2000 Mar;81 Pt 3:839-49. Unique Identifier : AIDSLINE MED/20141397; Morgan AL; Katzman M; Department of Microbiology, The Milton S. Hershey Medical Center,; Pennsylvania State University College of Medicine, Hershey, PA; 17033-0850, USA.; Many reports describe the characteristics of susceptible viral DNA substrates to various retroviral integrases during in vitro reactions in which manganese serves as the divalent cation cofactor for site-specific nicking. However, manganese is known to alter the specificity of some endonucleases and magnesium may be t
Th1 dominance in HAM/TSP and the optico-spinal form of multiple sclerosis versus Th2 dominance in mite antigen-specific IgE myelitis.: J Neurol Sci. 2000 Jan 1;172(1):17-24. Unique Identifier : AIDSLINE MED/20088932; Horiuchi I; Kawano Y; Yamasaki K; Minohara M; Furue M; Taniwaki T; Miyazaki T; Kira Ji; Department of Neurology, Neurological Institute, Graduate School; of Medical Sciences, Kyushu University, Fukuoka, Japan.; To clarify the Th1/Th2 balance in spinal cord inflammation, we used ELISA to measure the total and allergen-specific IgE in 69 patients with clinically definite multiple sclerosis (MS), including 24 patients with the optico-spinal form of MS, 45 with HAM/TSP, 30 HTLV-I carriers without HAM/TSP, 40 patients with acute
Dominant human herpesvirus type 8 RNA transcripts in classical and AIDS-related Kaposi's sarcoma.: J Pathol. 1999 Apr;187(5):582-7. Unique Identifier : AIDSLINE MED/99359555; Linderoth J; Rambech E; Dictor M; Department of Oncology, University of Lund Hospital, Solvegatan; 25, S-221 85 Lund, Sweden.; Skin biopsy sections of Kaposi s sarcoma (KS) from 25 patients (5 AIDS-related, 20 classical cases) were histologically staged and hybridized in situ with oligonucleotide probes for constitutively transcribed human herpesvirus 8 (HHV-8) mRNA T0.7 and T1.1 using a colourimetric technique. T1.1 increases during experime
Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group.: JAMA. 2000 Mar 15;283(11):1445-50. Unique Identifier : AIDSLINE MED/20195072; Gordin F; Chaisson RE; Matts JP; Miller C; de Lourdes Garcia M; Hafner R; Valdespino JL; Coberly J; Schechter M; Klukowicz AJ; Barry MA; O'Brien RJ; Veterans Affairs Medical Center and Georgetown University,; Washington, DC 20422, USA. vawrap@erols.com; CONTEXT: Because of problems with adherence, toxicity, and increasing resistance associated with 6- to 12-month isoniazid regimens, an alternative short-course tuberculosis preventive regimen is needed. OBJECTIVE: To compare a 2-month regimen of daily rifampin and pyrazinamide with a 12-month regimen of daily isoniazi
[Indonesia: the largest archipelago in the world]: Med Trop (Mars). 1999;59(3):229-32. Unique Identifier : AIDSLINE MED/20166024; Lescar S
[Evidence of risk factors for condom breakage among French military personnel stationed overseas]: Med Trop (Mars). 1999;59(3):266-70. Unique Identifier : AIDSLINE MED/20166032; Deparis X; Migliani R; Merlin M; Service de Medecine des Collectivites, l'Institut de Medecine; Tropicale du Service de Sante des Armees, Marseille, France.; medco@gulliver.fr; The French Army Medical Service has been distributing free condoms to overseas personnel since 1989. An epidemiologic study conducted in Cambodia showed that the rate of condom failure during protected sex was 16.3 p. 100. In view this high failure rate, a study to evaluate safet
[Chronic genital ulcerations and HIV infection: 29 cases]: Med Trop (Mars). 1999;59(3):279-82. Unique Identifier : AIDSLINE MED/20166035; Gbery IP; Djeha D; Kacou DE; Aka BR; Yoboue P; Vagamon B; Sangare A; Kanga JM; Centre de Dermatologie et Venereologie, Centre; Hospitalo-Universitaire de Treichville, Abidjan, Cote d'Ivoire.; gbery@africaonlineco.ci; Genital ulcers are common manifestations of infectious disease. The incidence of genital ulcers featuring a chronic course has increased since the beginning of the AIDS epidemic. The purpose of this 18-month cross-sectional study was to determine the main infectious causes of chronic genital ulcers (CGU) and their cor
[Hepatitis C virus: first pathogen found in blood donors in Burundi (letter)]: Med Trop (Mars). 1999;59(3):307. Unique Identifier : AIDSLINE MED/20166040; Ndihokubwayo JB; Ntirandekura D; Nzotungwanayo I; De Lamballerie X
[Risk of Chagas disease through transfusions in the Americans]: Medicina (B Aires). 1999;59 Suppl 2:125-34. Unique Identifier : AIDSLINE MED/20133433; Schmunis GA; Oficina Sanitaria Panamericana/Organizacion Mundial de la Salud,; Washington DC, USA. schmunig@paho.org; The safety of blood transfusion depends on a country s laws, decrees and/or regulations concerning the collection, production and use of blood and blood derivatives. It also needs governmental enforcement of those instruments, as well as trained health professionals to obtain blood and produce blood derivatives, follo
[TH1 response in the experimental infection with Trypanosoma cruzi]: Medicina (B Aires). 1999;59 Suppl 2:84-90. Unique Identifier : AIDSLINE MED/20133427; Cardoni RL; Antunez MI; Abrami AA; Instituto Nacional de Parasitologia Dr. M. Fatala Chaben (INP),; ANLIS Dr. C.G. Malbran, Buenos Aires. rita@inscha.gov.ar; Specific antibodies and the activation of phagocytic cells by IFN-gamma are the key elements of the immune response involved in protection of the T. cruzi infected host. The central role of the IFN-gamma in vivo seems to be the activation of the inducible nitric oxide synthetase of macrophages (iNOS) and the productio
Tissue wasting in patients with chronic obstructive pulmonary disease.: Neurol Clin. 2000 Feb;18(1):245-62. Unique Identifier : AIDSLINE MED/20126214; Farber MO; Mannix ET; Division of Pulmonary, Occupational, and Critical Care Medicine,; Department of Medicine, Indiana University School of Medicine,; Indianapolis , IN 46202, USA.; Malnutrition is common among individuals suffering from hypoxemic chronic obstructive pulmonary disease (COPD), advanced HIV disease, and in patients with chronic, severe congestive heart failure. Although increased morbidity and mortality has been associated with weight loss in these conditions, the pathophysiology o
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group [see comments]: N Engl J Med. 2000 Mar 30;342(13):921-9. Unique Identifier : AIDSLINE MED/20183102; Quinn TC; Wawer MJ; Sewankambo N; Serwadda D; Li C; Wabwire-Mangen F; Meehan MO; Lutalo T; Gray RH; National Institute of Allergy and Infectious Diseases, Bethesda,; MD, USA.; BACKGROUND AND METHODS: We examined the influence of viral load in relation to other risk factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In a community-based study of 15,127 persons in a rural district of Uganda , we identified 415 couples
HTLV-II-associated cutaneous T-cell lymphoma in a patient with HIV-1 infection.: N Engl J Med. 2000 Mar 30;342(13):930-6. Unique Identifier : AIDSLINE MED/20183103; Poiesz B; Dube D; Dube S; Love J; Papsidero L; Uner A; Hutchinson R; Department of Medicine, State University of New York Upstate; Medical University, Syracuse 13210, USA.
Investigators' responsibilities for human subjects in developing countries [editorial; comment]: N Engl J Med. 2000 Mar 30;342(13):967-9. Unique Identifier : AIDSLINE MED/20183108; Angell M
Preventing sexual transmission of HIV--new ideas from sub-Saharan Africa [editorial; comment] [see comments]: N Engl J Med. 2000 Mar 30;342(13):970-2. Unique Identifier : AIDSLINE MED/20183110; Cohen MS
Thalidomide in multiple myeloma [letter]: N Engl J Med. 2000 Mar 30;342(13):975; discussion 975-6. Unique Identifier : AIDSLINE MED/20183112; Kishi Y; Oki Y; Machida U
[Progressive multifocal leukoencephalopathy in AIDS. Overview and retrospective analysis of 17 patients]: Nervenarzt. 2000 Feb;71(2):96-104. Unique Identifier : AIDSLINE MED/20167655; Happe S; Lunenborg N; Rickert CH; Heese C; Reichelt D; Schuierer G; Schul C; Husstedt IW; Klinik und Poliklinik fur Neurologie, Westfalische; Wilhelms-Universitat Munster.; We describe retrospectively the course of 17 AIDS patients with progressive multifocal leukoencephalopathy (PML) and give a review of their clinical symptoms and survival times. The relative frequency of PML in our cohort of AIDS patients was 2.6%. The mean of CD4-positive cells was 80.5 +/- 82.5/microliter. CD4-posit
AIDS- and non-AIDS-related PML association with distinct p53 polymorphism.: Neurology. 2000 Feb 8;54(3):743-6. Unique Identifier : AIDSLINE MED/20143009; Power C; Gladden JG; Halliday W; Del Bigio MR; Nath A; Ni W; Major EO; Blanchard J; Mowat M; Department of Clinical Neurosciences, University of Calgary,; Alberta, Canada.; A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at cod
Cerebellar degeneration associated with HIV infection [letter]: Neurology. 2000 Feb 22;54(4):1012-3. Unique Identifier : AIDSLINE MED/20152871; Sclar G; Kennedy CA; Hill JM; McCormack MK
Cerebrovascular changes in the basal ganglia with HIV dementia.: Neurology. 2000 Feb 22;54(4):921-6. Unique Identifier : AIDSLINE MED/20152846; Berger JR; Nath A; Greenberg RN; Andersen AH; Greene RA; Bognar A; Avison MJ; Department of Neurology, University of Kentucky College of; Medicine, Lexington 40536-2184, USA. jrbneuro@pop.uky.edu; BACKGROUND: HIV dementia is a form of subcortical dementia. Clinical, radiologic, pathologic, and biochemical studies suggest a major contribution of basal ganglia dysfunction to the pathogenesis of this disorder. Many investigators have proposed a contribution of a disrupted blood
Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources.: Neurology. 2000 Feb 22;54(4):927-36. Unique Identifier : AIDSLINE MED/20152847; Ellis RJ; Gamst AC; Capparelli E; Spector SA; Hsia K; Wolfson T; Abramson I; Grant I; McCutchan JA; Department of Neurosciences, HIV Neurobehavioral Research Center,; University of California, San Diego, USA. roellis@ucsd.edu; OBJECTIVE: To identify the sources of HIV virions in CSF by modeling treatment-associated HIV dynamics. BACKGROUND: We postulated a model in which cell-free CSF virions originate from two major sources, namely, systemic non-CNS and CNS tissues, the latter including brain parenchyma and meninges. The model predicted th
Role of brain biopsy in the management of focal brain lesions in HIV-infected patients. Gruppo Italiano Cooperativo AIDS & Tumori.: Neurology. 2000 Feb 22;54(4):993-7. Unique Identifier : AIDSLINE MED/20152862; Antinori A; Ammassari A; Luzzati R; Castagna A; Maserati R; Rizzardini G; Ridolfo A; Fasan M; Vaccher E; Landonio G; Scerrati M; Rocca A; Butti G; Nicolato A; Lazzarin A; Tirelli U; Department of Infectious Diseases, IRCCS L. Spallanzani, Rome,; Italy.; In this multicenter, retrospective study of 160 brain biopsies in the assessment of HIV-related focal brain lesions, diagnostic sensitivity was acceptable (87%), but the procedure carried considerable morbidity (7.5%) and mortality (3.1%). Moreover, it is not always possible to initiate the changes in therapy indicate
International military human immunodeficiency virus/acquired immunodeficiency syndrome policies and programs: strengths and limitations in current practice.: Mil Med. 2000 Feb;165(2):87-92. Unique Identifier : AIDSLINE MED/20174142; Yeager R; Hendrix CW; Kingma S; Department of Political Science, West Virginia University,; Morgantown 26506, USA.; A survey was conducted to evaluate military human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) policies and programs in 119 countries. Ninety-eight percent of the 62 respondents provide prevention education, 95% in group settings but only 53% individually. Predeployment briefings are more commo
An autopsy report of graft-versus-host disease (GVHD) following blood transfusion.: Osaka City Med J. 1999 Jun;45(1):37-43. Unique Identifier : AIDSLINE MED/20188167; Otori K; Masuda C; Wanibuchi H; Nakanishi A; Kawabata K; Ohashi H; Fukushima S; First Department of Pathology, Osaka City University Medical; School, Japan.; A case of graft-versus-host disease (GVHD) associated with blood transfusion in a 71-year-old man is reported. The patient received transfusions (irradiation red cells M.A.P 14 units, fresh frozen plasma 11 units) and developed features of GVHD including fever, a skin rash, diarrhea, liver dysfunction, hypoplastic bon
Cytokine responses of C3H/HeN mice infested with Ixodes scapularis or Ixodes pacificus nymphs.: Parasite Immunol. 2000 Jan;22(1):31-40. Unique Identifier : AIDSLINE MED/20088952; Schoeler GB; Manweiler SA; Wikel SK; Department of Entomology and Plant Pathology, 127 Noble Research; Center, Oklahoma State University, Stillwater, Oklahoma 74078,; USA.; Lyme borreliosis, caused by Borrelia burgdorferi, is transmitted by Ixodes scapularis in the eastern and midwestern United States and by Ixodes pacificus in the far-Western United States. Studies have shown that infestation with I. scapularis nymphs modulates host cytokine production;
CMV in HIV-infected newborns [news]: Pediatr Res. 2000 Feb;47(2):173. Unique Identifier : AIDSLINE MED/20136804; Marodi L
Treatment-resistant expansion of CD8+CD28-cells in pediatric HIV infection.: Pediatr Res. 2000 Mar;47(3):418-21. Unique Identifier : AIDSLINE MED/20172979; Niehues T; Horneff G; Knipp S; Adams O; Wahn V; Department of Pediatrics, Heinrich Heine University, Dusseldorf,; Germany.; There is a disease stage-dependent loss of CD28 expression on T cells in HIV-infected children. In this study, T cell recovery, in particular CD28 expression on T cells, was analyzed after initiation of highly active antiretroviral therapy in a group of eight mostly treatment-naive HIV-infected children. Plasma HIV-RN
Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2.: Unique Identifier : AIDSLINE MED/20115930 P
Multiple copies of the Mason-Pfizer monkey virus constitutive RNA transport element lead to enhanced HIV-1 Gag expression in a context-dependent manner.: Nucleic Acids Res. 2000 Feb 15;28(4):901-10. Unique Identifier : AIDSLINE MED/20115916; Wodrich H; Schambach A; Krausslich HG; Heinrich-Pette-Institut fur experimentelle Virologie und; Immunologie an der Universitat Hamburg, Martinstrasse 52,; D-20251 Hamburg, Germany.; Retroviral gene expression requires nuclear export and translation of incompletely spliced RNA. In the case of human immunodeficiency virus (HIV), this is facilitated by the viral Rev protein binding to its cognate RNA response element (RRE), while other retroviruses contain constitutive transport elements (CTE) bindi
Prediction of common secondary structures of RNAs: a genetic algorithm approach.: Nucleic Acids Res. 2000 Feb 15;28(4):991-9. Unique Identifier : AIDSLINE GENBANK/M31113; Chen JH; Le SY; Maizel JV; Advanced Biomedical Computing Center, SAIC, NCI/FCRDC, Frederick,; MD 21702, USA. chen@ncifcrf.gov; In this study we apply a genetic algorithm to a set of RNA sequences to find common RNA secondary structures. Our method is a three-step procedure. At the first stage of the procedure for each sequence, a genetic algorithm is used to optimize the structures in a population to a certain degree of stability. In this ste
Antiviral therapy for chronic hepatitis B and C. Which patients are likely to benefit from which agents?: Postgrad Med. 2000 Feb;107(2):135-8, 141-4. Unique Identifier : AIDSLINE MED/20154003; Gordon SC; Division of Gastroenterology-Hepatology, William Beaumont; Hospital, Royal Oak, Michigan 48073-6769, USA.; sgordon@beaumont.edu; As primary care physicians become increasingly involved in diagnosis and treatment of patients with chronic viral hepatitis, an understanding of the antiviral options available, their limitations, and their side effects takes on a special importance. For chronic HBV infection, interferon alfa-2b requires only a 4-mont
Sexually transmitted diseases in women. Gonorrhea and syphilis.: Postgrad Med. 2000 Feb;107(2):181-4, 189-90, 193-7. Unique Identifier : AIDSLINE MED/20154006; Emmert DH; Kirchner JT; Department of Family and Community Medicine, Lancaster General; Hospital, PA 17604-3555, USA.; Gonorrhea has been declining since its 1975 peak. Risk factors include age 15 to 19 years, multiple or casual sexual contacts, sexual activity related to drug use, and low socioeconomic status. Infection is usually mild but may be asymptomatic. While no physical signs are specific to the gonococcus, pelvic inflammator
[AIDS: new FDA approved agents (news)]: Pharm Unserer Zeit. 2000 Jan;29(1):58. Unique Identifier : AIDSLINE MED/20166141; Forstenlehner M
Screening of selected plant extracts for in vitro inhibitory activity on HIV-1 reverse transcriptase (HIV-1 RT).: Pharmazie. 2000 Jan;55(1):75-7. Unique Identifier : AIDSLINE MED/20147502; Mlinaric A; Kreft S; Umek A; Strukelj B; Department of Pharmaceutical Biology, Faculty of Pharmacy,; University of Ljubljana, Slovenia.; Methanolic-aqueous extracts of 70 plants were investigated for their ability to inhibit HIV-1 reverse transcriptase activity in vitro. Two thirds of the extracts screened showed more than 50% inhibition. Two extracts inhibited the enzyme completely while four exhibited more than 90% inhibition. Tannins as nonspecific
International union of pharmacology. XXII. Nomenclature for chemokine receptors.: Pharmacol Rev. 2000 Mar;52(1):145-76. Unique Identifier : AIDSLINE MED/20164997; Murphy PM; Baggiolini M; Charo IF; Hebert CA; Horuk R; Matsushima K; Miller LH; Oppenheim JJ; Power CA; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. pmm@nih.gov; Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled receptors differentially expressed in diverse cell types. Biological activities have been most clearly defined in leukocytes, where chemokines coordinate development, differentiation, anatomic distribution, trafficking, and eff
[Serial assessment of the nutritional status of patients infected by the human immunodeficiency virus. Role of tumor necrosis factor/its receptors]: Rev Clin Esp. 1999 Dec;199(12):790-5. Unique Identifier : AIDSLINE MED/20152027; Segura Fernandez E; Domenech Cienfuegos I; Perez Guzman E; Guerrero Sanchez F; Escribano Moriana JC; Perez Cano R; Fernandez-Gutierrez del Alamo C; Giron Gonzalez JA; Servicio de Medicina Interna, Hospital Universitario Puerta del; Mar, Facultad de Medicina, Cadiz.; In order to analyze the nutritional status of HIV infected patients and the involvement of the tumour necrosis factor-alpha (TNF-alpha) and its soluble receptors (sTNFRI and sTNFRII) in such an status, forty HIV infected patients, with no associated systemic opportunist infections, were prospectively followed for eigh
[Lung nodules in a patient with HIV infection and severe neutropenia]: Rev Clin Esp. 1999 Dec;199(12):849-50. Unique Identifier : AIDSLINE MED/20152037; de Dios Perrino S; Alonso Claudio G; Arevalo Velasco A; Santos de Vega G; Fuertes Martin A; Jimenez Lopez A; Servicio de Medicina Interna II, Hospital Universitario,; Salamanca.
[Thrombocytopenic thrombotic purpura, HIV, and antiviral therapy (letter)]: Rev Clin Esp. 1999 Dec;199(12):859-60. Unique Identifier : AIDSLINE MED/20152044; Valencia Ortega ME; Gil Aguado A; Lavilla Uriol P; Gonzalez Lahoz J
[Arthritis and tenosynovitis caused by Mycobacterium kansasii associated with human immunodeficiency virus infection (letter)]: Rev Clin Esp. 1999 Dec;199(12):863. Unique Identifier : AIDSLINE MED/20152048; Pintado V; Antela A; Corres J; Martin-Davila P
[Nevirapine induces abstinence symptoms in patients on a methadone maintenance program with HIV infection]: Rev Clin Esp. 2000 Jan;200(1):12-4. Unique Identifier : AIDSLINE MED/20186061; Bano Rodrigo MD; Agujetas Rodriguez M; Lopez Garcia ML; Guillen Llera JL; Programa Municipal de Drogas de Majadahonda, Escuela de; especializacion de analisis clinicos, Facultad de Farmacia,; Universidad Complutense, Madrid.; The objective of this study was to investigate the potential inductive effect of nevirapine (NVP) with methadone. Eight patients on the methadone maintenance programme with anti-retroviral therapy because of their infection with HIV, well maintained w
[An intracranial mass in a patient with HIV infection]: Rev Clin Esp. 2000 Jan;200(1):33-4. Unique Identifier : AIDSLINE MED/20186067; Crespo Valades E; Vera Tome A; Diaz Pinto P; Sanchez Montero F; Munoz Sanz A; Unidad de Enfermedades Infecciosas, Hospital Regional; Universitario Infanta Cristina, Badajoz.
Simultaneous serological evidence of Actinobacillus pleuropneumoniae, PRRS, Aujeszky's disease and influenza viruses in Spanish finishing pigs.: Res Vet Sci. 2000 Feb;68(1):9-13. Unique Identifier : AIDSLINE MED/20150297; Gutierrez-Martin CB; Rodriguez-Delgado O; Alvarez-Nistal D; De La Puente-Redondo VA; Garcia-Rioja F; Martin-Vicente J; Rodriguez Ferri EF; Microbiology and Immunology Section. Department of Animal Health.; Faculty of Veterinary Medicine, University of Leon, 24071 -; Leon, Spain.; A total of 198 pigs with tachypnoea and temperature >/= 40 degrees C were selected on a Spanish finishing unit, and their sera were examined for antibodies to Actinobacillus pleuropneumoniae (App), porcine reproductive and respiratory syndrome virus (PRRSV), Aujeszky disease virus (ADV), and swine influenza virus (SI
Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts.: Semin Diagn Pathol. 2000 Feb;17(1):56-65. Unique Identifier : AIDSLINE MED/20184832; Adsay NV; Hasteh F; Cheng JD; Klimstra DS; Department of Pathology, The Karmanos Cancer Institute-Detroit; Medical Center, Wayne State University, MI 48076, USA.; adsayv@med.wayne.edu; In the pancreas, 3 types of morphologically similar lesions may present as squamous cysts : Lymphoepithelial cysts, dermoid cysts (monodermal teratomas), and epidermoid cysts in intrapancreatic accessory spleen. Lymphoepithelial cysts (LECs) are seen predominantly in men (M/F: 4/1) and in adulthood (mean age, 56, and
[The general medical importance of oral health. The 5th Annual Meeting of the Swiss Association for Preventive and Restorative Dentistry (SVPR) of 13 November 1999 in Zurich]: Schweiz Monatsschr Zahnmed. 2000;110(2):211-2. Unique Identifier : AIDSLINE MED/20205587; Gruninger A
Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.: Science. 2000 Mar 24;287(5461):2274-7. Unique Identifier : AIDSLINE MED/20196025; Faure S; Meyer L; Costagliola D; Vaneensberghe C; Genin E; Autran B; Delfraissy JF; McDermott DH; Murphy PM; Debre P; Theodorou I; Combadiere C; Laboratoire d'Immunologie Cellulaire et Tissulaire, Centre; National de la Recherche Scientifique UMR 7627, Hopital; Pitie-Salpetriere, Paris, France.; Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor a
Antenatal HIV screening--knowledge, attitudes and practices of obstetricians in KKH.: Singapore Med J. 1999 Dec;40(12):733-7. Unique Identifier : AIDSLINE MED/20174198; Tan TY; Teo KP; Tan KH; Department of Maternal-Fetal Medicine, KK Women's and Children's; Hospital, Singapore.; AIM OF STUDY: To determine the knowledge, attitudes and practices of obstetricians with regards to HIV screening in pregnant women. METHOD: This is a cross-sectional study based on a questionnaire survey of all obstetricians in KKH from January to August 1997. MAIN OUTCOME MEASURES: Obstetricians knowledge and belief
Health and disease in southern Africa: a comparative and vulnerability perspective.: Soc Sci Med. 2000 Apr;50(7-8):965-83. Unique Identifier : AIDSLINE MED/20177402; Kalipeni E; Department of Geography, University of Illinois at; Urbana-Champaign, Urbana 61801, USA. kalipeni@uiuc.edu; Using a vulnerability and comparative perspective, this paper examines the status of health in southern Africa highlighting the disease complex and some of the factors for the deteriorating health conditions. It is argued that aggregate social and health care indicators for the region such as life expectancy and infan
Disclosure of HIV status and its consequences [letter]: S Afr Med J. 1999 Dec;89(12):1238. Unique Identifier : AIDSLINE MED/20142672; Mathews C; Kuhn L; Fransman D; Hussey G; Dikweni L
HIV seropositivity in the Western Cape [letter]: S Afr Med J. 1999 Dec;89(12):1239. Unique Identifier : AIDSLINE MED/20142673; Edge J; van der Merwe AE
AZT--the saga continues [news]: S Afr Med J. 1999 Dec;89(12):1244-5. Unique Identifier : AIDSLINE MED/20142677; Simon-Meyer J
Clinical progression of HIV infection in adults.: S Afr Med J. 1999 Dec;89(12):1255-8. Unique Identifier : AIDSLINE MED/20142681; Maartens G; Department of Medicine, University of Cape Town.
Microbiologically proven Pneumocystis carinii pneumonia (PCP) at Ga-Rankuwa Hospital [letter]: S Afr Med J. 1999 Dec;89(12):1274-5. Unique Identifier : AIDSLINE MED/20142686; Sein PP; Hoosen AA; Mzileni MO
Intracranial mass lesions in HIV-positive patients--the KwaZulu/Natal experience. Neuroscience AIDS Research Group.: S Afr Med J. 1999 Dec;89(12):1284-8. Unique Identifier : AIDSLINE MED/20142689; Bhigjee AI; Naidoo K; Patel VB; Govender D; Department of Neurology, Wentworth Hospital, Durban.; BACKGROUND: Neurological disease heralds the development of AIDS in 10-20% of HIV-seropositive individuals. In over half of these cases the presentation will be that of an intracranial mass lesion (IML). In developed countries toxoplasmosis is the most frequent cause of IML in a positive patient, followed by primary c
Management of opportunist mycobacterial infections: Joint Tuberculosis Committee Guidelines 1999. Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society.: Thorax. 2000 Mar;55(3):210-8. Unique Identifier : AIDSLINE MED/20146100
Expression of human immunodeficiency virus type 1 Gag protein precursor and envelope proteins from a vesicular stomatitis virus recombinant: high-level production of virus-like particles containing HIV envelope.: Virology. 2000 Mar 1;268(1):112-21. Unique Identifier : AIDSLINE MED/20149227; Haglund K; Forman J; Krausslich HG; Rose JK; Department of Pathology, Yale University School of Medicine, New; Haven, Connecticut, 06510, USA.; Recombinant vesicular stomatitis viruses have been developed as high-level expression vectors which serve as effective vaccine vectors in animals (Roberts et al., 1998, J. Virol. 72, 4704-4711; Roberts et al., 1999, J. Virol. 73, 3723-3732). Here we show that two genes can be expressed simultaneously from a single, li
Peripheral blood mononuclear cells of HIV- and HCV-antibody-positive individuals contain HCV RNA but No HCV DNA despite evidence for reverse transcription of HIV RNA into DNA.: Virology. 2000 Mar 1;268(1):12-6. Unique Identifier : AIDSLINE MED/20149216; Penning M; Beld M; Goudsmit J; Department of Human Retrovirology, University of Amsterdam,; Amsterdam, The Netherlands.; Following reports of the finding of cDNA of RNA viruses in cells containing an endogenous retrovirus-encoded reverse transcriptase, we looked for the presence of hepatitis C virus (HCV) DNA in peripheral blood mononuclear cells (PBMC) of injecting drug users seropositive for both HCV and human immunodefiency virus (HI
Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens.: Unique Identifier : AIDSLINE MED/20149228; Kovarik J; Martinez X; Pihlgren M; Bozzotti P; Tao MH; Kipps TJ; Wild TF; Lambert PH; Siegrist CA; World Health Organization Collaborating Centre for Neonatal; Vaccinology, University of Geneva Medical School, Geneva,; Switzerland. jiri.kovarik@medecine.unige.ch; The limited induction of Th1 and cytotoxic immune responses is regarded as the main reason for the increased susceptibility to intracellular microorganisms in early life. Recently, in vitro IL-12 supplementation was shown to enhance the limited IFN-gamma release of measles-specific infant T cells. Using a series of IL
Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immunodeficient mouse strains.: Virology. 2000 Mar 1;268(1):17-28. Unique Identifier : AIDSLINE MED/20149217; Ellison AR; Yang L; Voytek C; Margolis TP; Francis I. Proctor Foundation, Department of Ophthalmology,; University of California at San Francisco Medical Center, 95; Kirkham Street, San Francisco, California, 94143, USA.; Productive infection with herpes simplex virus (HSV) type 1 is limited by both innate and adaptive immune mechanisms. The purpose of the current study was to determine whether these mechanisms also play a role in the establishment of latent HSV infection. First we examined the trigeminal ganglia (TG) of severe combine
Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus.: Virology. 2000 Mar 1;268(1):201-17. Unique Identifier : AIDSLINE MED/20149236; Cinquina CC; Grogan E; Sun R; Lin SF; Beardsley GP; Miller G; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut, 06520, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV) is the first human virus known to encode dihydrofolate reductase (DHFR), an enzyme required for nucleotide and methionine biosynthesis. We have studied the purified KSHV-DHFR enzyme in vitro and analyzed its expression in cultured B-cell lines derived from primary effusio
The HTLV receptor is a widely expressed protein.: Virology. 2000 Mar 1;268(1):41-8. Unique Identifier : AIDSLINE MED/20149219; Trejo SR; Ratner L; Washington University School of Medicine, St. Louis, Missouri,; 63110, USA.; The receptor for human T-cell leukemia virus type 1 (HTLV-1) was found to be expressed on a broad range of cell lines derived from multiple species. Receptor expression was assessed using human immunodeficiency virus type 1 particles, pseudotyped with the HTLV-1 envelope glycoprotein, and expressing luciferase under t
Canine cyclin T1 rescues equine infectious anemia virus tat trans-activation in human cells.: Virology. 2000 Mar 1;268(1):7-11. Unique Identifier : AIDSLINE MED/20149215; Albrecht TR; Lund LH; Garcia-Blanco MA; Department of Genetics, Duke University Medical Center, Durham,; North Carolina, 27710, USA.; Human immunodeficiency virus-1 Tat protein and human Cyclin T1 mediate transcriptional activation by enhancing the elongation efficiency of RNA polymerase II. Activation of transcription of the related equine infectious anemia virus (EIAV) requires a similar protein known as eTat, which does not function in human cell
Construction of a selectable nef-defective live-attenuated human immunodeficiency virus expressing Escherichia coli gpt gene.: Unique Identifier : AIDSLINE MED/20149223; Tanuri A; Jesus da Costa L; Brindeiro R; Ramos CA; Pau CP; Rayfield MA; We have developed a replication-competent human immunodeficiency virus (HIV) carrying a selective marker that can be used in vivo. This recombinant virus (Z6 Delta nef gpt) was generated by replacing the 5 half of the HIV nef gene with the Escherichia coli guanine phosphoribosyl transferase gene (gpt). This new vecto
The kinetics of specific immune responses in rhesus monkeys inoculated with live recombinant BCG expressing SIV Gag, Pol, Env, and Nef proteins.: Virology. 2000 Mar 1;268(1):94-103. Unique Identifier : AIDSLINE MED/20149225; Leung NJ; Aldovini A; Young R; Jarvis MA; Smith JM; Meyer D; Anderson DE; Carlos MP; Gardner MB; Torres JV; Department of Medical Microbiology, School of Medicine,; University of California, Davis, California, 95616, USA.; Development of an effective preventive or therapeutic vaccine against HIV-1 is an important goal in the fight against AIDS. Effective virus clearance and inhibition of spread to target organs depends principally on the cellular immune response. Therefore, a vaccine against HIV-1 should elicit virus-specific cytotoxic
Vitamin E and immunity.: Vitam Horm. 2000;59:305-36. Unique Identifier : AIDSLINE MED/20178592; Moriguchi S; Muraga M; Department of Nutrition, Faculty of Human Life Science, Yamaguchi; Prefectural University, Japan.; Vitamin E is a potent antioxidant and has an ability to modulate host immune functions. This chapter consists of five parts: (1) vitamin E deficiency and immunity, (2) vitamin E supplementation and immunity, (3) vitamin E and the decreased cellular immunity with aging, (4) vitamin E and T-cell differentiation in the t
Bloodborne viruses in forensic medical practice in South Africa.: Am J Forensic Med Pathol. 1999 Dec;20(4):364-8. Unique Identifier : AIDSLINE MED/20088269; du Plessis R; Webber L; Saayman G; Department of Forensic Medicine, Institute of Pathology,; University of Pretoria, Republic of South Africa.; rdplessi@medic.up.co.za; Health care workers are at risk of exposure to bloodborne viruses including human immunodeficiency virus types 1 and 2 (HIV-1 and 2), hepatitis B virus (HBV) and hepatitis C virus (HCV). However, limited data is available regarding these risks to forensic medical personnel who are exposed daily to large numbers of sev
Reactivation of hepatitis B in patients with human immunodeficiency virus infection treated with combination antiretroviral therapy.: Am J Med. 2000 Feb 15;108(3):249-51. Unique Identifier : AIDSLINE MED/20186530; Proia LA; Ngui SL; Kaur S; Kessler HA; Trenholme GM; Section of Infectious Diseases, Rush Presbyterian-St Luke's; Hospital, Chicago, Illinois 60612, USA.
Fungal flora on cutaneous and mucosal surfaces of cats infected with feline immunodeficiency virus or feline leukemia virus.: Am J Vet Res. 2000 Feb;61(2):158-61. Unique Identifier : AIDSLINE MED/20148123; Sierra P; Guillot J; Jacob H; Bussieras S; Chermette R; Equipe de Parasitologie-Mycologie, UMR INRA-AFSSA-ENVA Biologie; Moleculaire et Immunologie Parasitaires et Fongiques, Ecole; Nationale Veterinaire dAlfort, Maisons-Alfort, France.; OBJECTIVE: To compare cutaneous and mucosal mycoflora in cats infected with FIV or FeLV with that in noninfected cats. ANIMALS: 85 client-owned cats; 24 seropositive for FIV, 10 seropositive for FeLV, 1 seropositive for both viruses, and 50 seronegative for both viruses. PROCEDURE: Cutaneous specimens were obtained fr
Lamivudine-associated remission of chronic hepatitis delta [letter]: Ann Intern Med. 2000 Apr 4;132(7):598. Unique Identifier : AIDSLINE MED/20186700; Andreone P; Spertini F; Negro F
Modulation of glutathione synthetic enzymes by acidic fibroblast growth factor.: Arch Biochem Biophys. 2000 Mar 1;375(1):201-9. Unique Identifier : AIDSLINE MED/20148381; Choi J; Opalenik SR; Wu W; Thompson JA; Forman HJ; Department of Molecular Pharmacology, University of Southern; California School of Pharmacy, Los Angeles, California, 90033,; USA.; Increasing evidence suggests that glutathione (GSH) synthesis is a regulated process. Documented increases in gamma-glutamylcysteine synthetase (GCS) occur in response to oxidants, in tumors, on plating cells at a low cell density, and with nerve growth factor stimulation, suggesting that GSH synthesis may be related
Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? [see comments]: Arch Dermatol. 2000 Mar;136(3):323-7. Unique Identifier : AIDSLINE MED/20186788; Garcia-Doval I; LeCleach L; Bocquet H; Otero XL; Roujeau JC; Department of Dermatology, Hospital Provincial de Pontevedra,; Spain.; BACKGROUND: Withdrawal of the drug(s) that cause severe cutaneous adverse reactions is usually recommended without proof that it alters the course of those reactions. OBJECTIVE: To determine whether the timing of causative drug withdrawal is related to the prognosis of patients with toxic epidermal necrolysis (TEN) or
Cutaneous aspergillosis and acquired immunodeficiency syndrome [see comments]: Arch Dermatol. 2000 Mar;136(3):365-9. Unique Identifier : AIDSLINE MED/20186793; Murakawa GJ; Harvell JD; Lubitz P; Schnoll S; Lee S; Berger T; Department of Dermatology, University of California, San; Francisco, USA. murakag@mail.amc.edu; BACKGROUND: Primary cutaneous aspergillosis is an uncommon finding in patients with acquired immunodeficiency syndrome (AIDS); only 13 cases have been reported in the literature. OBSERVATIONS: We describe 11 patients with primary cutaneous aspergillosis and AIDS. There does not seem to be an age, sex, race, or human i
Human immunodeficiency virus infection and cutaneous aspergillosis [editorial; comment]: Arch Dermatol. 2000 Mar;136(3):412-4. Unique Identifier : AIDSLINE MED/20186803; Roilides E; Farmaki E
Does an infected peripancreatic fluid collection or abscess mandate operation?: Ann Surg. 2000 Mar;231(3):361-7. Unique Identifier : AIDSLINE MED/20177111; Baril NB; Ralls PW; Wren SM; Selby RR; Radin R; Parekh D; Jabbour N; Stain SC; Department of Surgery, University of Southern California School; of Medicine, Los Angeles, USA.; OBJECTIVE: To assess the treatment of peripancreatic fluid collections or abscess with percutaneous catheter drainage (PCD). SUMMARY BACKGROUND DATA: Surgical intervention has been the mainstay of treatment for infected peripancreatic fluid collections and abscesses. Increasingly, PCD has been used, with mixed results
Cardiac manifestations of acquired immunodeficiency syndrome.: Unique Identifier : AIDSLINE MED/20186612; Rerkpattanapipat P; Wongpraparut N; Jacobs LE; Kotler MN; Acquired immunodeficiency syndrome is a serious problem
The effect of acute severe illness on CD4+ lymphocyte counts in nonimmunocompromised patients [letter]: Arch Intern Med. 2000 Mar 13;160(5):715-6. Unique Identifier : AIDSLINE MED/20186630; Aldrich J; Gross R; Adler M; King K; MacGregor RR; Gluckman SJ
Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin and its derivatives with triazole.: Arzneimittelforschung. 2000 Jan;50(1):55-9. Unique Identifier : AIDSLINE MED/20147341; Pandeya SN; Sriram D; Nath G; de Clercq E; Department of Pharmaceutics, Banaras Hindu University, Varanasi,; India. snpande@banaras.ernet.in; Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4 -pyridyl)-4-amino-5-mercapto-4-(H)-1,2,4-triazole to form Schiff bases and the N-Mannich bases of these compounds were synthesised by reacting them with formaldehyde and several secondary amines. Their chemical structures ha
A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.: AIDS. 2000 Feb 18;14(3):F25-32. Unique Identifier : AIDSLINE MED/20179239; Carr A; Miller J; Law M; Cooper DA; HIV, Immunology and Infectious Diseases Clinical Services Unit,; St Vincent's Hospital, University of New South Wales, Sydney,; Australia. acarr@stvincents.com.au; BACKGROUND: Lipodystrophy (LD; peripheral lipoatrophy, central adiposity) hyperlipidaemia and insulin resistance often complicate protease inhibitor-containing antiretroviral therapy. Lipoatrophy and abdominal distension were observed in protease inhibitor-naive nucleoside analogue reverse transcriptase inhibitor (NRT
HIV-1 strains from a cohort of American subjects reveal the presence of a V2 region extension unique to slow progressors and non-progressors.: AIDS. 2000 Feb 18;14(3):213-23. Unique Identifier : AIDSLINE MED/20179240; Wang B; Spira TJ; Owen S; Lal RB; Saksena NK; Retroviral Genetics Laboratory, Center for Virus Research,; Westmead Hospital, University of Sydney, Australia.; OBJECTIVES: To determine the molecular nature of HIV-1 quasispecies and their evolution, in vivo over time, in an American cohort of 22 homosexual men [four rapid progressors (RP), 15 slow progressors (SP) and three long-term non-progressors (LTNP)], infected with HIV-1 between 1982 and 1983, and to assess the possibl
Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection.: AIDS. 2000 Feb 18;14(3):225-33. Unique Identifier : AIDSLINE MED/20179241; Wilson JD; Ogg GS; Allen RL; Davis C; Shaunak S; Downie J; Dyer W; Workman C; Sullivan S; McMichael AJ; Rowland-Jones SL; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, UK.; OBJECTIVE: HIV-specific cytotoxic T lymphocytes (CTL) are believed to play an important role in containing viral replication throughout HIV-1 infection. Previous studies have attempted to quantify the HIV-1-specific CTL precursor frequency during primary HIV infection by using limiting dilution analysis, which almost
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors [editorial; comment]: AIDS. 2000 Feb 18;14(3):235-6. Unique Identifier : AIDSLINE MED/20179242; Clayette P; Jorajuria S; Dormont D
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors [editorial] [see comments]: AIDS. 2000 Feb 18;14(3):237-42. Unique Identifier : AIDSLINE MED/20179243; Huisman MT; Smit JW; Schinkel AH
Time of initiation of antiretroviral therapy: impact on HIV-1 viraemia. The Swiss HIV Cohort Study.: AIDS. 2000 Feb 18;14(3):243-9. Unique Identifier : AIDSLINE MED/20179244; Yerly S; Kaiser L; Perneger TV; Cone RW; Opravil M; Chave JP; Furrer H; Hirschel B; Perrin L; Laboratory of Virology, Geneva University Hospital, Switzerland.; OBJECTIVE: The current recommendation that patients infected with HIV-1 be treated early is based on little evidence. We examined whether the early initiation of antiretroviral treatment affects residual HIV-1 viraemia. METHODS: Viraemia was measured using an assay with a detection limit of 3 HIV-1 RNA copies/ml in dr
Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume.: AIDS. 2000 Feb 18;14(3):251-61. Unique Identifier : AIDSLINE MED/20179245; Vigano A; Vella S; Saresella M; Vanzulli A; Bricalli D; Di Fabio S; Ferrante P; Andreotti M; Pirillo M; Dally LG; Clerici M; Principi N; Pediatric Department IV, University of Milan, Ospedale Luigi; Sacco, Italy. alevig@mailserver.unimi.it; DESIGN: Despite significant rises in total CD4 T cells, the process of immune reconstitution in adults with HIV infection treated with potent antiretroviral treatment results in a rather slow increase in phenotypically naive lymphocytes. In children more than in adults, thymic function may be at least partly restored
HIV-1 genotypic zidovudine drug resistance and the risk of maternal--infant transmission in the women and infants transmission study. The Women and Infants Transmission Study Group.: AIDS. 2000 Feb 18;14(3):263-71. Unique Identifier : AIDSLINE MED/20179246; Welles SL; Pitt J; Colgrove R; McIntosh K; Chung PH; Colson A; Lockman S; Fowler MG; Hanson C; Landesman S; Moye J; Rich KC; Zorrilla C; Japour AJ; Division of Epidemiology, University of Minnesota, School of; Public Health, Minneapolis 55454, USA. welles@epi.umn.edu; OBJECTIVES: Although the treatment of pregnant women and their infants with zidovudine (ZDV) has been remarkably effective in preventing the perinatal transmission of human HIV-1, many potentially preventable infections still occur. To examine whether the risk of perinatal infection is increased among women who carry
Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea.: AIDS. 2000 Feb 18;14(3):273-8. Unique Identifier : AIDSLINE MED/20179247; Moore RD; Wong WM; Keruly JC; McArthur JC; Johns Hopkins University School of Medicine, Baltimore, Maryland; 21205, USA.; BACKGROUND: Sensory neuropathy is a common adverse effect of the nucleoside analogue anti-retroviral drugs didanosine (ddl) and stauvudine ( d4T ). These drugs are increasingly being used in combination, and it is not currently known whether the inciden
Geographic variation of HIV infection in childbearing women with syphilis in the United States.: AIDS. 2000 Feb 18;14(3):279-87. Unique Identifier : AIDSLINE MED/20179248; Koumans EH; Sternberg M; Gwinn M; Swint E; Zaidi A; St Louis ME; Division of STD Prevention, Centers for Disease Control, Atlanta,; Georgia 30333, USA.; OBJECTIVES: Substantial biologic and epidemiologic data indicate the importance of syphilis as a potential cofactor for sexual transmission of HIV infection, but few detailed data exist on the geographic covariation of these two important sexually transmitted infections. DESIGN: HIV prevalence in childbearing women an
HIV-1 diversity in France, 1996-1998. The AC 11 laboratory network.: AIDS. 2000 Feb 18;14(3):289-96. Unique Identifier : AIDSLINE MED/20179249; Couturier E; Damond F; Roques P; Fleury H; Barin F; Brunet JB; Brun-Vezinet F; Simon F; European Centre for the Epidemiological Monitoring of AIDS,; Hopital National de Saint-Maurice, France.; OBJECTIVE: To study the distribution of HIV-1 subtypes in France and to describe the characteristics of patients infected with non-B subtypes. METHODS: All adults who tested HIV-1 positive on Western blot for the first time in one of the participating laboratories between September
Behavioral and biologic evidence of persistent high-risk behavior in an HIV primary care population.: AIDS. 2000 Feb 18;14(3):297-301. Unique Identifier : AIDSLINE MED/20179250; Erbelding EJ; Stanton D; Quinn TC; Rompalo A; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: To define the prevalence of gonorrhea, chlamydial infection, and high-risk sexual behavior in an HIV primary care clinic. DESIGN: Subjects enrolling in this cross-sectional study answered a brief interviewer-administered questionnaire and provided a urine sample for gonorrhea and chlamydia testing. SETTING:
Comparison of sexual behaviors, unprotected sex, and substance use between two independent cohorts of gay and bisexual men.: AIDS. 2000 Feb 18;14(3):303-11. Unique Identifier : AIDSLINE MED/20179251; Craib KJ; Weber AC; Cornelisse PG; Martindale SL; Miller ML; Schechter MT; Strathdee SA; Schilder A; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To compare demographic characteristics, sexual practices, unprotected receptive and insertive anal intercourse, substance use and rates of HIV-1 seroconversion between two prospective cohorts of HIV-negative men who have sex with men. DESIGN: Comparative analysis of two independent cohorts. METHODS: Between
The prevalence and incidence of HIV-1 infection and syphilis in a cohort of police officers in Dar es Salaam, Tanzania: a potential population for HIV vaccine trials.: AIDS. 2000 Feb 18;14(3):313-20. Unique Identifier : AIDSLINE MED/20179252; Bakari M; Lyamuya E; Mugusi F; Aris E; Chale S; Magao P; Jossiah R; Janabi M; Swai A; Pallangyo N; Sandstrom E; Mhalu F; Biberfeld G; Pallangyo K; Muhimbili University College of Health Sciences, Dar es Salaam,; Tanzania.; OBJECTIVES: To assess the suitability of a cohort of police officers in Dar es Salaam for HIV vaccine trials by determining the prevalence and incidence of HIV-1 infection, active syphilis and their associated factors. Design and setting: An open cohort study of police officers in Dar es Salaam,
Epidemiology of thrombosis in HIV-infected individuals. The Adult/Adolescent Spectrum of HIV Disease Project.: AIDS. 2000 Feb 18;14(3):321-4. Unique Identifier : AIDSLINE MED/20179253; Sullivan PS; Dworkin MS; Jones JL; Hooper WC; Division of HIV/AIDS Prevention, National Center for Infectious; Diseases, Atlanta, Georgia 30333, USA. pss0@cdc.gov; OBJECTIVE: To describe the incidence of clinically recognized thrombosis and associated factors among individuals infected with HIV. DESIGN: A longitudinal medical record review. SETTING: Over 100 medical clinics in nine US cities. PATIENTS: A total of 42 935 individuals aged 13 years or older with HIV infection, obse
Is post-exposure prophylaxis affordable? [letter; comment]: AIDS. 2000 Feb 18;14(3):325. Unique Identifier : AIDSLINE MED/20179254; Pinkerton SD; Holtgrave DR; Kahn JG
A reality check: the cost of making post-exposure prophylaxis available to gay and bisexual men at high sexual risk [letter] [see comments]: AIDS. 2000 Feb 18;14(3):325-6. Unique Identifier : AIDSLINE MED/20179255; Low-Beer S; Weber AE; Bartholomew K; Landolt M; Oram D; Montaner JS; O'Shaughnessy MV; Hogg RS
Diversity of HIV-1 genetic subtypes in France, in the context of mother-to-child transmission. The French Pediatric Cohort Study Group [letter]: AIDS. 2000 Feb 18;14(3):327-8. Unique Identifier : AIDSLINE MED/20179256; Chaix ML; Manigart O; Letourneur F; Burgard M; Mayaux MJ; Rouzioux C
HIV virions and HIV replication are unaffected by granulysin [letter]: AIDS. 2000 Feb 18;14(3):328-30. Unique Identifier : AIDSLINE MED/20179257; Mackewicz CE; Ridha S; Levy JA
Normalization of the CD4 T cell receptor repertoire after evolution of syncytium-inducing HIV-1 variants [letter]: AIDS. 2000 Feb 18;14(3):330-1. Unique Identifier : AIDSLINE MED/20179258; Kostense S; Krop E; Blaak H; Schuitemaker H; Miedema F
Efavirenz associated with corticosteroids in patients with previous severe hypersensitivity reaction due to nevirapine [letter]: AIDS. 2000 Feb 18;14(3):331-2. Unique Identifier : AIDSLINE MED/20179259; Podzamczer D; Consiglio E; Ferrer E; Gudiol F
Excess peripheral neuropathy in patients treated with hydroxyurea plus didanosine and stavudine for HIV infection [letter]: AIDS. 2000 Feb 18;14(3):332-3. Unique Identifier : AIDSLINE MED/20179260; Cepeda JA; Wilks D
Relationship between Kaposi's sarcoma, Kaposi's sarcoma-associated herpesvirus and AIDS dementia complex [letter]: AIDS. 2000 Feb 18;14(3):333-5. Unique Identifier : AIDSLINE MED/20179261; Dupin N; Marcelin AG; Caumes E; Barete S; Arkoub ZA; Bossi P; Agher R; Calvez V
Rash as side-effect of nelfinavir in children [letter]: AIDS. 2000 Feb 18;14(3):335-6. Unique Identifier : AIDSLINE MED/20179262; Fortuny C; Vicente MA; Medina MM; Gonzalez-Ensenat A
Carpal tunnel syndrome in HIV-1 patients: a metabolic consequence of protease inhibitor use? [letter]: AIDS. 2000 Feb 18;14(3):336-8. Unique Identifier : AIDSLINE MED/20179263; Sclar G
Continuous low dose Thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer.: Br J Cancer. 2000 Feb;82(4):812-7. Unique Identifier : AIDSLINE MED/20194889; Eisen T; Boshoff C; Mak I; Sapunar F; Vaughan MM; Pyle L; Johnston SR; Ahern R; Smith IE; Gore ME; Department of Medicine, Royal Marsden Hospital, London, UK.; To grow and metastasize, solid tumours must develop their own blood supply by neo-angiogenesis. Thalidomide inhibits the processing of mRNA encoding peptide molecules including tumour necrosis factor-alpha (TNF-alpha) and the angiogenic factor vascular endothelial growth factor (VEGF). This study investigated the use
Central nervous system abnormalities in pediatric human immunodeficiency virus infection.: Pediatr Neurosurg. 1999 Sep;31(3):115-23. Unique Identifier : AIDSLINE MED/20170645; Gavin P; Yogev R; Department of Pediatrics, Northwestern University Medical School,; The Children's Memorial Hospital, Chicago, IL 60614, USA.; With the recent improvements in treatment of HIV, the disease has become a chronic one. The mean survival time of HIV-infected children is now 9-10 years, which is more than 4 times the mean age of such children who died in 1990. Yet, the prevalence of HIV encephalopathy has not decreased despite use of HAART. Rather,
Utility of microcalorimetry in the characterization of the browning reaction.: J Pharm Biomed Anal. 1999 Jun;20(1-2):385-8. Unique Identifier : AIDSLINE MED/20166812; Vickery RD; Maurin MB; Pharmacy R&D, DuPont Pharmaceuticals Company, Experimental; Station, Wilmington, DE 19880-0400, USA.; An isothermal microcalorimeter was utilized to characterize a model solid-state interaction. The degradation of the HIV protease inhibitor, DMP 450, in a binary mixture with hydrous lactose was followed in the presence of 5% additional water. Heat produced in the microcalorimeter sample vessel from either chemical or
HPLC-UV method for the quantitation of nevirapine in biological matrices following solid phase extraction.: J Pharm Biomed Anal. 1999 Jun;20(1-2):91-8. Unique Identifier : AIDSLINE MED/20166778; Pav JW; Rowland LS; Korpalski DJ; Department of Drug Metabolism and Pharmacokinetics, Boehringer; Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.; Nevirapine (VIRAMUNE) is a non-nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency virus type 1 (HIV-1), currently marketed for the treatment of HIV-1 infected adults. A reverse phase HPLC-UV method was optimized and validated for the determination of
LC determination of indinavir in biological matrices with electrochemical detection.: J Pharm Biomed Anal. 2000 Mar;22(2):307-14. Unique Identifier : AIDSLINE MED/20182833; Fizzano MR; Valvo L; Dupuis ML; Mennella V; Cianfriglia M; Laboratorio di Chimica del Farmaco, Istituto Superiore di; Sanita, Rome, Italy.; A high performance liquid chromatographic (HPLC) method with electrochemical detection for the quantification of Indinavir in cell culture is described. The sample pre-treatment involved a protein precipitation procedure using acetonitrile. Chromatogr
Transient eosinophilia by HIV infection.: Ann Hematol. 2000 Feb;79(2):99-101. Unique Identifier : AIDSLINE MED/20203968; Maeda Y; Miyatake J; Naiki Y; Nawata H; Sumimoto Y; Sono H; Sakaguchi M; Matsuda M; Kanamaru A; Third Department of Internal Medicine, Kinki Universit