Efficient split synthesis for targeted libraries.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Efficient split synthesis for targeted libraries.

J Comb Chem. 2000 Jan-Feb;2(1):10-8. Unique Identifier : AIDSLINE MED/20214068
Cohen B; Skiena S; Department of Computer Science, State University of New York at; Stony Brook 11794-4400, USA.

Abstract: We propose a new approach for fabricating more sophisticated combinatorial chemistry libraries via split synthesis and evaluate its potential through extensive simulation. Our algorithmically intensive method promises to reduce the time and materials costs of synthesizing libraries which are (1) too large to synthesize economically by sequential or parallel synthesis, (2) too long or irregular for conventional split synthesis generation techniques, and (3) not used in sufficient quantity to justify the setup costs of array makers. It also encourages the design of more focused and interesting libraries than are typically constructed using split synthesis. Our algorithms automate the design of efficient synthesis procedures for motif-based libraries which are too complex to design by hand. Our software allows the user to select the most desirable tradeoff between minimizing the number of steps in the synthesis process and containing the combinatorial explosion of the number of compounds synthesized.

Keywords: JOURNAL ARTICLE Algorithms Animal Chemistry, Organic/ECONOMICS/*METHODS Chickens Databases, Factual DNA-Binding Proteins/CHEMICAL SYNTHESIS Human Models, Chemical *Peptide Library SIV/CHEMISTRY Transcription Factors/CHEMICAL SYNTHESIS
000730
A0071402

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 2000. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2000. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .