2000

HIV/AIDS: impact on healing.: Ostomy Wound Manage. 2000 Mar;46(3):30-40, 42, 44 passim; quiz 48-9. Unique Identifier : AIDSLINE MED/20249393; Burns J; Pieper B; Detriot Medical Center, Infections Diseases Clinic, MI 48201,; USA.; Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) are leading chronic illnesses in many major cities worldwide. Frequently, people with HIV infection require surgery or develop chronic wounds. This paper summarizes the impact of HIV infection on body organs and systems and the effect of a
The prime-boost strategy: exciting prospects for improved vaccination.: Immunol Today. 2000 Apr;21(4):163-5. Unique Identifier : AIDSLINE MED/20206409; Ramshaw IA; Ramsay AJ; Division of Immunology and Cell Biology, John Curtin School of; Medical Research, Australian National University, Canberra, ACT; 2601, Australia.
Induction of specific immune tolerance with hybrid antibodies.: Immunol Today. 2000 Apr;21(4):172-6. Unique Identifier : AIDSLINE MED/20206410; Staerz UD; Lee DS; Qi Y; Dept of Immunology, National Jewish Medical and Research Center,; 1400 Jackson Street, Denver, CO 80206, USA. staerzu@njc.org
Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells.: Immunol Today. 2000 Apr;21(4):183-6. Unique Identifier : AIDSLINE MED/20206412; D'Ambrosio D; Iellem A; Colantonio L; Clissi B; Pardi R; Sinigaglia F; Roche Milano Ricerche, Milan, Italy. daniele.dambrosio@roche.com
Cytokine profile data [letter]: Immunol Today. 2000 Apr;21(4):199-200. Unique Identifier : AIDSLINE MED/20206417; Cohen S
A variant of myelokathexis with hypogammaglobulinemia: lymphocytes as well as neutrophils may reverse in response to infections.: Pediatr Hematol Oncol. 2000 Mar;17(2):171-6. Unique Identifier : AIDSLINE MED/20198835; Arai J; Wakiguchi H; Hisakawa H; Kubota H; Kurashige T; Department of Pediatrics, Kochi Medical School, Japan.; A 7-year-old boy with prolonged and marked leukopenia diagnosed at 6 months of age is described. The polymorphonuclear cells presented no hypersegmented nuclei or concentrated nuclear chromatin, although vacuolated myeloid cells appeared in bone marrow smears. Neutrophils reversed in response to administration of G-CS
Septic arthritis in hemophilia with central venous catheter: a case report.: Pediatr Hematol Oncol. 2000 Mar;17(2):187-9. Unique Identifier : AIDSLINE MED/20198838; Li CH; Ou Y; Lee AC; So KT; Department of Paediatrics, Tuen Mun Hospital, New Territories,; Hong Kong, China.; A case is reported of septic arthritis in a child with human immunodeficiency virus-negative hemophilia A associated with a Staphylococcus aureus catheter-associated septicemia. The infection occurred in relation to the use of a totally implantable central venous catheter. The organism was eventually eradicated with a
The influence of highly active antiretroviral therapy on AIDS-associated Kaposi's sarcoma.: Br J Dermatol. 1999 May;140(5):875-81. Unique Identifier : AIDSLINE MED/99282216; Dupin N; Rubin De Cervens V; Gorin I; Calvez V; Pessis E; Grandadam M; Rabian C; Viard JP; Huraux JM; Escande JP; Service de Dermato-Venereologie, Hopital Tarnier-Cochin,; Paris, France; Laboratoire de Virologie, Groupe Hospitalier; Pitie-Salpetriere, Paris, France. nicolas@icr.ac.uk; To assess the clinical and biological benefit of highly active antiretroviral therapy on AIDS-associated Kaposi s sarcoma (KS), 13 patients with AIDS-associated Kaposi s sarcoma (five pulmonary KS and eight cutaneous KS) were prospectively followed for a mean duration of 12 months. Six patients were treated with speci
Latex allergy in atopic children.: Br J Dermatol. 1999 May;140(5):919-21. Unique Identifier : AIDSLINE MED/99282224; Holme SA; Lever RS; University Department of Dermatology, Western Infirmary,; Dumbarton Road, Glasgow G11 6NB, U.K.; The incidence of positive circulating specific immunoglobulin E (IgE) antibodies to latex and evidence of clinical latex sensitivity appears to be increasing since its first description in 1979. Although heightened medical awareness may be a factor, exposure to latex products, particularly rubber gloves, has increased
HIV-associated pityriasis rubra pilaris responsive to triple antiretroviral therapy.: Br J Dermatol. 1999 May;140(5):931-4. Unique Identifier : AIDSLINE MED/99282227; Gonzalez-Lopez A; Velasco E; Pozo T; Del Villar A; Departments of Dermatology, Rio Hortega University Hospital,; Valladolid, Spain.; HIV-associated pityriasis rubra pilaris (PRP) or PRP type VI designates a new distinctive entity reported in HIV patients. It is characterized by cutaneous lesions of PRP and variable association with lesions of acne conglobata, hidradenitis suppurativa and lichen spinulosus. We report a patient with HIV-associated PR
Nevirapine-induced overlap stevens-johnson syndrome/toxic epidermal necrolysis [letter]: Br J Dermatol. 1999 May;140(5):980-2. Unique Identifier : AIDSLINE MED/99282248; Wetterwald E; Le Cleach L; Michel C; David F; Revuz J
Factors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection.: Br J Dermatol. 1999 Nov;141(5):852-8. Unique Identifier : AIDSLINE MED/20050249; Tsang CS; Samaranayake LP; Faculty of Dentistry, University of Hong Kong, The Prince Philip; Dental Hospital, Hong Kong.; Adherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free indi
Lack of evidence of human herpesvirus 8 DNA sequences in HIV-negative patients with systemic plasmacytosis [letter]: Br J Dermatol. 1999 Nov;141(5):942-3. Unique Identifier : AIDSLINE MED/20050277; Okada H; Kano R; Watanabe S
Selective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4(+) T cells.: Int Immunol. 2000 Mar;12(3):253-61. Unique Identifier : AIDSLINE MED/20166977; Labuda T; Sundstedt A; Dohlsten M; BMC Immunobiology, Department of Tumor Immunology, University of; Lund, Solvegatan 21, 223 62 Lund, Sweden.; We have recently described the novel A6H antigen expressed on human peripheral blood T cells and on renal cell carcinoma cells. Cross-linking of the A6H antigen results in co-stimulation of human CD4(+) T cells, characterized by induction of the transcription factor activator protein-1 (AP-1), proliferation and promin
Synthetic oligodeoxynucleotide containing CpG motif induces an anti-polysaccharide type 1-like immune response after immunization of mice with Haemophilus influenzae type b conjugate vaccine.: Unique Identifier : AIDSLINE MED/20166981; von Hunolstein C; Teloni R
Mapping the B cell superantigen binding site for HIV-1 gp120 on a V(H)3 Ig.: Int Immunol. 2000 Mar;12(3):305-12. Unique Identifier : AIDSLINE MED/20166982; Neshat MN; Goodglick L; Lim K; Braun J; Department of Pathology and Laboratory Medicine, and The; Molecular Biology Institute, University of California-Los; Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA.; The emerging class of B cell superantigens includes HIV-1 gp120, which binds to many members of the V(H)3 Ig gene family. The present study addresses the structural features of V(H)3 antibodies conferring gp120 binding activity using a panel of recombinant full-length and Fab Ig proteins. Binding activity was fully co
Functional heterogeneity among bone marrow-derived dendritic cells conditioned by T(h)1- and T(h)2-biasing cytokines for the generation of allogeneic cytotoxic T lymphocytes.: Int Immunol. 2000 Mar;12(3):335-42. Unique Identifier : AIDSLINE MED/20166985; Sato M; Iwakabe K; Ohta A; Sekimoto M; Nakui M; Koda T; Kimura S; Nishimura T; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Tokai University School of; Medicine, Isehara 259-1193, Kanagawa, Japan.; Three distinct bone marrow (BM)-derived dendritic cells (BMDC) were expanded from BALB/c BM cells by culture with (i) granulocyte macrophage colony stimulating factor (GM-CSF) plus IL-3, (ii) GM-CSF, IL-3 plus T(h)1-biasing cytokines (IL-12 and IFN-gamma) or (iii) GM-CSF, IL-3 plus T(h)2-biasing cytokines (IL-4). All
A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II.: Biochemistry. 2000 Apr 4;39(13):3782-7. Unique Identifier : AIDSLINE MED/20202065; Zhou N; Luo Z; Luo J; Hall JW; Huang Z; Kimmel Cancer Institute, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.; The viral macrophage inflammatory protein-II (vMIP-II) encoded by Kaposi s sarcoma-associated herpesvirus is unique among all known chemokines in that vMIP-II shows a broad-spectrum interaction with both CC and CXC chemokine receptors including CCR5 and CXCR4, two principal coreceptors for the cell entry of human immu
Computer-assisted instruction: an effective instructional method for HIV prevention education?: J Adolesc Health. 2000 Apr;26(4):244-51. Unique Identifier : AIDSLINE MED/20200139; Evans AE; Edmundson-Drane EW; Harris KK; Department of Kinesiology and Health Promotion, University of; Texas at Austin, Austin, Texas 78712, USA.; PURPOSE: To compare the effectiveness of a computer-assisted instruction (CAI)-based intervention to a more traditional lecture-based intervention for influencing psychosocial correlates of human immunodeficiency virus (HIV) preventive behaviors. METHODS: Students enrolled in a Human Sexuality course (N = 152) were ra
Predictors of HIV antibody testing among Gay, Lesbian, and bisexual youth.: J Adolesc Health. 2000 Apr;26(4):252-7. Unique Identifier : AIDSLINE MED/20200140; Maguen S; Armistead LP; Kalichman S; Psychology Department, Georgia State University, Atlanta, Georgia; 30303, USA.; PURPOSE: To identify factors related to human immunodeficiency virus (HIV) antibody testing among Gay, Lesbian, and bisexual youth. METHODS: Self-reported demographics, risk behaviors, variables related to the Health Belief Model, and HIV testing data were collected at a conference for gay youth, as well as at the Gay
Preventing HIV transmission: the perspective of inner-city Puerto Rican adolescents.: J Adolesc Health. 2000 Apr;26(4):258-67. Unique Identifier : AIDSLINE MED/20200141; Ramirez JI; Gossett DR; Ginsburg KR; Taylor SL; Slap GB; Craig-Dalsimer Division of Adolescent Medicine, University of; Pennsylvania, Philadelphia, Pennsylvania, USA.; PURPOSE: To examine the development of HIV prevention strategies that address the concerns and needs of urban Puerto Rican adolescents. METHODS: The study included 542 Puerto-Rican adolescents, divided into age sets of 12 to 14 years and 15 to 19 years. Participants were recruited from community work programs, recreat
The African-American church: a potential forum for adolescent comprehensive sexuality education.: J Adolesc Health. 2000 Apr;26(4):289-94. Unique Identifier : AIDSLINE MED/20200144; Coyne-Beasley T; Schoenbach VJ; Department of Pediatrics and Department of Internal Medicine,; School of Medicine, University of North Carolina at Chapel Hill,; 27599, USA.; PURPOSE: To investigate the attitudes and beliefs of clergy from African-American churches towards sexuality education and the provision of sexuality education in their churches. METHODS: A pilot study was designed to survey a convenience sample of clergy leaders from African-American churches about their young adoles
Determining needs and setting priorities for HIV-affected and HIV-infected persons: northeast Ohio and San Diego.: J Health Care Poor Underserved. 2000 Feb;11(1):77-86. Unique Identifier : AIDSLINE MED/20240512; Loue S; Faust M; O'Shea D; Department of Epidemiology and Biostatistics, Case Western; Reserve University, School of Medicine, MetroHealth Medical; Center, Cleveland, OH 44109-1998, USA.; The Ryan White Comprehensive AIDS Resources Emergency (CARE) Act of 1991 requires that communities receiving Title I funding engage in a needs assessment and priority process to guide the allocation of those funds to various services within the local community. This paper reports on the process and results of the need
Rationalizing the purchase and use of gloves in health care.: Br J Nurs. 1999 Mar 11-24;8(5):279-82, 284, 286-7. Unique Identifier : AIDSLINE MED/99291107; Ross S; Wakefield and Pontefract Community Health NHS Trust, Fieldhead; Hospital.; The last two decades have seen a substantial increase in the use of protective gloves in healthcare establishments. This is attributed to the widespread publicity regarding the risks of transmission of human immunodeficiency virus and hepatitis B and C from blood and body fluid contact. Further, directives from offici
T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell's palsy, hearing loss, neuronitis vestibularis, and Meniere's disease.: Eur Arch Otorhinolaryngol Suppl. 1994;:S447-8. Unique Identifier : AIDSLINE MED/20236232; Bumm P; Schlimok G; ENT Clinic, Zentralklinikum, Augsburg, Germany.
Electrophysiologic pattern and T-cell subsets in Bell's palsy.: Eur Arch Otorhinolaryngol Suppl. 1994;:S449-51. Unique Identifier : AIDSLINE MED/20236233; Formenti A; Galli M; Termine G; Corbellino M; Massetto N; ENT Department, Fatebenefratelli Hospital, Milan, Italy.
Facial palsy and human immunodeficiency virus infection.: Eur Arch Otorhinolaryngol Suppl. 1994;:S498-500. Unique Identifier : AIDSLINE MED/20236249; Schot LJ; Devriese PP; Hadderingh RJ; Portegies P; Enting RH; Department of Otorhinolaryngology, Academic Medical Centre,; Amsterdam, The Netherlands.
Recurrent facial paralysis associated with HIV infection.: Eur Arch Otorhinolaryngol Suppl. 1994;:S518-20. Unique Identifier : AIDSLINE MED/20236253; Hoffmann DF; Oregon Health Sciences University Portland 97202, USA.
[Ocular damage during HIV infection at the University Hospital Center of Casablanca. (Apropos of 400 cases)]: Bull Soc Pathol Exot. 2000 Feb;93(1):14-6. Unique Identifier : AIDSLINE MED/20236301; el Mansouri Y; Zaghloul K; Himmich H; Amraoui A; Service d'ophtalmologie, Hopital 20 aout 1953, Casablanca,; Maroc. yelmansouri@pfizer.co.ma; The objective of this study was to report ocular manifestations in Moroccan patients infected with HIV/AIDS. 400 patients were surveyed retrospectively from 1993 to 1998 as part of a co-operative study undertaken by the departments of infectious diseases and ophtalmology of the Casablanca Teaching Hospital. Of the 400
[Toxoplasma serology in HIV infected patients and suspected cerebral toxoplasmosis at the Central Hospital of Bobo-Dioulasso (Burkina Faso)]: Bull Soc Pathol Exot. 2000 Feb;93(1):17-9. Unique Identifier : AIDSLINE MED/20236302; Millogo A; Ki-Zerbo GA; Traore W; Sawadogo AB; Ouedraogo I; Peghini M; chnss.bobo@fasonet.bf; A study was conducted in the Internal Medicine unit of Bobo-Dioulasso Hospital. Of the 1828 HIV positive patients admitted in medical wards, 268 presented neurological symptoms. 25.4% had positive Toxoplasma gondii serology. Encephalitis was associated with 12.5% of this latter group and intracranial hypertension with
[Prevalence of HTLV-1 virus infection in Togo (Kozah prefecture and the University Hospital Center of Lome]: Bull Soc Pathol Exot. 2000 Feb;93(1):3-5. Unique Identifier : AIDSLINE MED/20236297; Balogou AA; Grunitzky EK; Anani TK; Kowu A; Sadzo-Hetsu A; Nubukpo KA; Dumas M; Service de neurologie, CHU, Lome, Togo.; abalogou@syfed.tg.refer.org; The aim of this study was to determine the prevalence of Human T cell Leukaemia Virus Type 1 (HTLV1) in a representative population sample, in neurological and non-neurological patients hospitalised in the Lome teaching hospital in order to study the clinical manifestations of this retrovirus. There was no statistical
[Adult non-viral lymphocytic meningitis in Abidjan (Cote d'Ivoire)]: Bull Soc Pathol Exot. 2000 Feb;93(1):50-4. Unique Identifier : AIDSLINE MED/20236311; Eholie SP; Adou-Brynh D; Domoua K; Kakou A; Ehui E; Gouamene A; Bonnard D; Aoussi E; Bissagnene E; Kadio A; Service des maladies infectieuses et tropicales, CHU de; Treichville, Abidjan, Cote d'Ivoire.; Our prospective and longitudinal study aimed to analyse the aetiologies, clinical features and prognostic of non viral lymphocytes meningitis (NVLM). We recruited 131 patients, 77 males (59%) and 54 females (41%) sex-ratio 1.4. The mean age was 35 years [15-67]. 117 patients were HIV positive (89%) and 14 (11%) were H
Universal HIV testing in pregnancy [editorial]: Can Fam Physician. 2000 Mar;46:508-10, 519-22. Unique Identifier : AIDSLINE MED/20215447; Ratnapalan S; Diav-Citrin O; King SM; Koren G
Pulmonary infection in human immunodeficiency virus-infected patients in Taiwan.: J Formos Med Assoc. 2000 Feb;99(2):123-7. Unique Identifier : AIDSLINE MED/20232902; Fang CT; Hung CC; Chang SC; Hsueh PR; Chang YL; Chen MY; Luh KT; Department of Internal Medicine, National Taiwan University; Hospital, Taipei.; BACKGROUND: Pulmonary infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients. METHODS: We conducted a retrospective analysis of the pathogens causing pulmonary infection in 272 HIV-infected patients admitted to a university hospital from January 1993 through Decem
Parvovirus B19 infection in a human immunodeficiency virus-infected patient with anemia.: J Formos Med Assoc. 2000 Feb;99(2):162-5. Unique Identifier : AIDSLINE MED/20232908; Lau SM; Yu WL; Chow KC; Wang JH; Department of Internal Medicine, China Medical College Hospital,; Taichung, Taiwan.; Anemia is generally attributed to zidovudine therapy in human immunodeficiency virus (HIV)-infected patients, although parvovirus B19 infection has been reported as a rare cause. We report on a 24-year-old homosexual man infected with HIV who presented with anemia. He had received aggressive daily antiretroviral thera
Recent advances in the study, prevention, and treatment of infectious diseases.: J Formos Med Assoc. 2000 Feb;99(2):92-9. Unique Identifier : AIDSLINE MED/20232898; Huang LM; Department of Pediatrics, National Taiwan University Hospital,; Taipei, Taiwan.; Along with the rapid progress in molecular biology and computer technology, many changes have occurred in the diagnosis, treatment, prevention, and understanding of infectious diseases. Molecular techniques are taking a more important role both in the diagnosis and in the discovery of etiologic agents. The association
Gene trap insertional mutagenesis in mice: new vectors and germ line mutations in two novel genes.: Transgenic Res. 1999;8(6):451-8. Unique Identifier : AIDSLINE GENBANK/AF064783; Neilan EG; Barsh GS; Department of Pediatrics, Stanford University, Palo Alto, CA; 94305, USA.; Insertional mutagenesis based on gene trap vectors that capture endogenous splice sites is a promising tool for functional genomics. Several groups have proposed large-scale gene trap screens, but questions remain as to the type of vectors and their design. We report a set of plasmid-encoded gene trap vectors and the
[Ocular manifestations in HIV infected patients attending the department of ophthalmology of Universidade Federal de Sao Paulo]: Rev Assoc Med Bras. 1999 Oct-Dec;45(4):323-6. Unique Identifier : AIDSLINE MED/20215699; Matos KT; Santos MC; Muccioli C; Departamento de Oftalmologia, Universidade Federal de Sao Paulo.; PURPOSE: To evaluate ocular manifestations of HIV-infected patients. MATERIAL AND METHODS: A retrospective study of 1,100 HIV positive out patients in 3 years with a standard complete ophthalmological exam. RESULTS: Eight hundred and sixty nine (79%) of the 1,100 patients studied were male and 231 (21%) female. The mo
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 2000 Mar 31;10(13):123-4. Unique Identifier : AIDSLINE MED/20240464
[Reactive hemophagocytic syndrome in children]: Arch Pediatr. 2000 Mar;7(3):278-86. Unique Identifier : AIDSLINE MED/20224672; Stephan JL; Galambrun C; Unite d'hematologie et d'oncologie pediatrique, Hopital Nord,; CHRU, Saint-Etienne, France.; Reactive haemophagocytic syndrome is characterized by activation and uncontrolled non-malignant proliferation of T lymphocytes and macrophages, leading to a cytokine overproduction, which accounts for the main biological signs. Children usually present with an acute febrile illness, fulminant pancytopenia and hepatosp
[Comparative characteristics of immunoglobulin-synthesizing cell and immunoregulatory T-lymphocyte subpopulation contents in human lymphatic nodes and the spleen]: Morfologiia. 1998;114(6):47-9. Unique Identifier : AIDSLINE MED/20226698; Pigarevskii PV; N.N. Anichkov Laboratory of Atherosclerosis, Russian Academy of; Medical Sciences, St. Petersburg.; The content of lymphocytes producing different classes of immunoglobulins (IgA, IgM and IgG) and immunoregulatory T cell subpopulations (CD3, CD4, CD8) was assessed in structural components of T- and B- zones of lymph nodes of visceral and somatic groups and spleen in man. Forensic autopsy material obtained from 48 me
Application of bacteriophages as surrogates for mammalian viruses: a case for use in filter validation based on precedents and current practices in medical and environmental virology.: PDA J Pharm Sci Technol. 1999 Mar-Apr;53(2):75-82. Unique Identifier : AIDSLINE MED/20217408; Aranha-Creado H; Brandwein H; Scientific and Laboratory Services Department, Pall Corporation,; Port Washington, New York, USA.; Infectivity-based assays are the assays of choice for the detection of pathogenic mammalian viruses. While it is intuitively appropriate to conduct testing and validation studies with the known viral burden or a closely related mammalian species, logistic considerations often dictate otherwise. Consequently, bacteriop
HTLV-I infection and the low prevalence of Helicobacter pylori infection in Japan [comment]: Eur J Gastroenterol Hepatol. 1999 May;11(5):481-3. Unique Identifier : AIDSLINE MED/20216025; Walker M; Department of Histopathology, Imperial College School of Medicine; at St Mary's, London. mm.walker@ic.ac.uk; HTLV-I retrovirus infection and Helicobacter pylori infection are common in Japan ; however a report in this issue shows a significantly low prevalence of H. pylori in patients infected with HTLV-I. The reasons for this may be due to differences in genetic susceptibility of the infec
Low prevalence of Helicobacter pylori in individuals with HTLV-I infection [see comments]: Eur J Gastroenterol Hepatol. 1999 May;11(5):497-502. Unique Identifier : AIDSLINE MED/20216028; Isomoto H; Mizuta Y; Fukushima K; Takeshima F; Miyazaki M; Murase K; Omagari K; Maeda T; Kamihira S; Tomonaga M; Kohno S; Second Department of Internal Medicine, Nagasaki University; School of Medicine, Japan.; BACKGROUND: The prevalence of Helicobacter pylori in HIV-positive individuals is significantly lower than in HIV-negative controls. However, its prevalence in individuals infected with human T-cell leukaemia virus type I (HTLV-I), another important member of the human retrovirus family, has not been previously investi
Monitoring specific T-cell responses to melanoma vaccines: ELISPOT, tetramers, and beyond.: Clin Diagn Lab Immunol. 2000 Mar;7(2):141-4. Unique Identifier : AIDSLINE MED/20169410; Gajewski TF; Department of Pathology and Department of Medicine, Section of; Hematology/Oncology, The University of Chicago, Chicago, Illinois; 60637, USA. tgajewsk@medicine.bsd.uchicago.edu
Expression of regeneration and tolerance factor correlates directly with human immunodeficiency virus infection and inversely with hepatitis C virus infection.: Clin Diagn Lab Immunol. 2000 Mar;7(2):200-5. Unique Identifier : AIDSLINE MED/20169419; Sung CC; Boomer JS; Givens TS; DuChateau BK; Lepe MR; Feller A; Westerman MP; Gilman-Sachs A; Chedid A; Beaman KD; Clinical Immunology Laboratory, Department of Microbiology and; Immunology, North Chicago, Illinois 60064, USA.; Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause two of the most prevalent debilitating viral infections. HIV appears to induce a skewing toward a Th2 response, while in HCV infection a Th1 response appears to dominate. Regeneration and tolerance factor (RTF) may participate in driving or sustainin
Relationship between IS901 in the Mycobacterium avium complex strains isolated from birds, animals, humans, and the environment and virulence for poultry.: Clin Diagn Lab Immunol. 2000 Mar;7(2):212-7. Unique Identifier : AIDSLINE MED/20169421; Pavlik I; Svastova P; Bartl J; Dvorska L; Rychlik I; Veterinary Research Institute, Hudcova 70, 621 32 Brno, Czech; Republic. pavlik@vri.cz; A total of 738 strains of Mycobacterium avium complex (MAC) were examined in biological experiments on poultry by use of PCR methods with primers for detection of the insertion sequence IS901. Serotype strains of MAC from all known 28 serotypes were examined. Further strains were isolated from human immunodeficiency v
Transmission of human T-cell lymphotropic virus type 1 tax to rabbits by tax-only-positive human cells.: Clin Diagn Lab Immunol. 2000 Mar;7(2):274-8. Unique Identifier : AIDSLINE MED/20169430; Zucker-Franklin D; Pancake BA; Lalezari P; Khorshidi M; New York University School of Medicine, New York, New York 10016,; USA.; The human T-cell lymphrotropic virus type 1 (HTLV-1) is causally related to adult T-cell leukemia and lymphoma and the neurodegenerative diseases tropical spastic paraparesis and HTLV-1-associated myelopathy. In the United States the prevalence of infection has been estimated to range
CD8(+) T-cell gamma interferon production specific for human immunodeficiency virus type 1 (HIV-1) in HIV-1-infected subjects.: Clin Diagn Lab Immunol. 2000 Mar;7(2):279-87. Unique Identifier : AIDSLINE MED/20169431; Huang XL; Fan Z; Kalinyak C; Mellors JW; Rinaldo CR Jr; University of Pittsburgh Graduate School of Public Health,; Pittsburgh, Pennsylvania 15261, USA.; The CD8(+)-T-cell response to human immunodeficiency virus type 1 (HIV-1) is considered to be important in host control of infection and prevention of AIDS. We have developed a single-cell enzyme immunoassay (enzyme-linked immunospot assay) specific for gamma interferon (IFN-gamma) production stimulated by either auto
Phagocytic function of monocytes in children with human immunodeficiency virus type 1 infection.: Clin Diagn Lab Immunol. 2000 Mar;7(2):296-7. Unique Identifier : AIDSLINE MED/20169434; Tardei G; Duiculescu D; Capo C; Diaconu CC; Mutiu A; Mege JL; Cernescu CE; St. S. Nicolau Institute of Virology, Bucharest, Romania.; gtardei@hotmail.com; We investigated the phagocytic function of monocytes in 7- to 10-year-old children horizontally infected with human immunodeficiency virus type 1 (HIV-1) in comparison to that in healthy sex- and age-matched controls. CR3-mediated phagocytosis was increased in patients with HIV-associated pulmonary tuberculosis, indep
Identification of different states of hepatitis B virus infection with a quantitative PCR assay.: Clin Diagn Lab Immunol. 2000 Mar;7(2):298-300. Unique Identifier : AIDSLINE MED/20169435; Kessler HH; Preininger S; Stelzl E; Daghofer E; Santner BI; Marth E; Lackner H; Stauber RE; Molecular Diagnostics Laboratory, Institute of Hygiene, Karl; Franzens University, A-8010 Graz, Austria.; harald.kessler@kfunigraz.ac.at; The level of hepatitis B virus (HBV) DNA in serum reflects the replicative activity of HBV. To compare serum HBV DNA levels in different states of hepatitis B, 47 sera of patients with HBeAg-positive chronic hepatitis B, 4 sera of patients with HBeAg-negative chronic hepatitis B, 40 samples of patients after HBeAg ser
Hitting up in the top end: characteristics of needle exchange clients in Darwin.: Aust N Z J Public Health. 2000 Feb;24(1):82-5. Unique Identifier : AIDSLINE MED/20240453; Roberts C; Crofts N; Health for Injectors in the Northern Territory, Northern; Territory AIDS Council, Darwin. goodhint@octa4.net.au; OBJECTIVE: Little is known about injecting drug use (IDU) and blood-borne viral (BBV) infection in rural Australia . METHOD: These repeat cross-sectional studies were conducted during a two-week period in July and October-November 1998 at the Darwin needle exchange, with 129 and
Eradication of disseminated lymphomas with CpG-DNA activated T helper type 1 cells from nontransgenic mice.: Cancer Res. 2000 Mar 15;60(6):1515-20. Unique Identifier : AIDSLINE MED/20210673; Egeter O; Mocikat R; Ghoreschi K; Dieckmann A; Rocken M; Department of Dermatology and Allergology,; Ludwig-Maximilians-University, Munich, Germany.; Various evidence suggests that adoptive transfer of polyclonal, tumor-specific, IFN-gamma-producing CD4+ T cells [T helper type 1 (Th1) cells] should be highly efficient for tumor immune therapy. However, this approach could not be tested because very few MHC class II-restricted tumor peptides have been defined. Here
Preclinical evaluation of "whole" cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes.: Cancer Res. 2000 Mar 15;60(6):1663-70. Unique Identifier : AIDSLINE MED/20210695; Ali SA; McLean CS; Boursnell ME; Martin G; Holmes CL; Reeder S; Entwisle C; Blakeley DM; Shields JG; Todryk S; Vile R; Robins RA; Rees RC; Department of Life Sciences, Nottingham Trent University, United; Kingdom.; The development of genetically modified whole tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors. In the present study, we have used a disabled infectious single cycle-herpes simplex virus 2 (DISC-HSV-2) vector constructed to express cytokine or marker gene
Therapeutic drug monitoring of saquinavir in patients during protease inhibitor therapy with saquinavir alone or in combination with ritonavir or nelfinavir.: Eur J Med Res. 2000 Feb 28;5(2):59-62. Unique Identifier : AIDSLINE MED/20203459; Langmann P; Zilly M; Weissbrich B; Schlor C; Vath T; Richter E; Klinker H; Medizinische Poliklinik, University of Wuerzburg, Division of; Infectious Diseases, Germany. p.langmann@medizin.uni-wuerzburg.de; Therapeutic drug monitoring is essential in HIV-patients undergoing highly active antiretroviral therapy (HAART). Saquinavir (SQV) is used alone or in combination with ritonavir (RTV) or nelfinavir (NLF), respectively, in the context of the HAART drug
MR spectroscopy in HIV and stimulant dependence HNRC Group. HIV Neurobehavioral Research Center [letter]: J Int Neuropsychol Soc. 2000 Jan;6(1):83-5. Unique Identifier : AIDSLINE MED/20224437; Taylor MJ; Alhassoon OM; Schweinsburg BC; Videen JS; Grant I
Interactions of HIV-1 NEF with cellular signal transducing proteins.: Front Biosci. 2000 Feb 1;5:D268-83. Unique Identifier : AIDSLINE MED/20169473; Renkema HG; Saksela K; Institute of Medical Technology, University of Tampere,; FIN-33101, Tampere, Finland.; Nef is a 27 - 34 kD myristoylated protein unique to primate lentiviruses. A functional Nef gene is important for development of high viremia and simian AIDS in SIV infected rhesus macaques (1). In a transgenic mouse model expression of Nef protein alone when expressed under a CD4-promoter is sufficient to cause an AID
In HIV-1-infected patients, plasma levels of HIV-1 RNA are inversely correlated with IFN-alpha responsiveness of whole-blood cultures to sendai virus.: J Clin Virol. 2000 Apr;16(2):123-8. Unique Identifier : AIDSLINE MED/20188072; Chehadeh W; Chabou S; Fontier C; Alm G; Lion G; Bocket L; Mouton Y; Wattre P; Hober D; Laboratoire de Virologie, Centre Hospitalier Regional; Universitaire, Institut Gernez-Rieux, 59037, Lille, France.; BACKGROUND: A diminished or totally blocked IFN-alpha production in cells from HIV-1-infected patients has been reported. OBJECTIVE: To investigate the relationship between the decreased in vitro production of IFN-alpha and the plasma level of HIV-1 RNA. STUDY DESIGN: Whole blood samples of 39 healthy subjects and 44
Seroprevalence of human T-lymphotropic virus type 1 in Papua New Guinea and Irian Jaya measured using different western blot criteria.: J Clin Virol. 2000 Apr;16(2):129-33. Unique Identifier : AIDSLINE MED/20188073; Takao S; Ishida T; Bhatia KK; Saha N; Soemantri A; Kayame OW; Department of Anthropology, Unit of Human Biology and Genetics,; Faculty of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo,; Japan.; BACKGROUND: Endemic foci of HTLV-1 carriers have been found in the world, however, the origin of HTLV-1 in humans is still unclear. Since a distinct type of virus strain was isolated from the Solomon Islands , detailed surveys on HTL
2nd International Conference on HIV and Iron. Brugge, Belgium, March 31-April 1, 2000. Abstracts.: J Clin Virol. 2000 Apr;16(2):77-105. Unique Identifier : AIDSLINE MED/20256087
Modeling the epidemiology and economics of directly observed therapy in Baltimore [see comments]: Int J Tuberc Lung Dis. 2000 Mar;4(3):201-7. Unique Identifier : AIDSLINE MED/20213116; Chaulk CP; Friedman M; Dunning R; Annie E. Casey Foundation, Baltimore, Maryland 21202, USA.; patc@aecf.org; SETTING: From 1958 to 1978, Baltimore maintained one of the highest pulmonary tuberculosis (TB) rates in the US. But, from 1978 to 1992 its TB rate declined by 64.3% and its ranking for TB fell from second highest among large US cites to twenty-eighth. This TB trend coincided with the implementation of an aggressive d
Anti-tuberculosis drug resistance in Portugal.: Int J Tuberc Lung Dis. 2000 Mar;4(3):223-31. Unique Identifier : AIDSLINE MED/20213119; Antunes ML; Aleixo-Dias J; Antunes AF; Pereira MF; Raymundo E; Rodrigues MF; Direccao-Geral da Saude, Lisbon, Portugal. maria.antunes@ip.pt; SETTING: A survey based upon a representative sample of smear-positive pulmonary tuberculosis patients was undertaken in Portugal , as part of the World Health Organization s Global Project on Anti-Tuberculosis Drug Resistance Survei
Diagnosing HIV-associated tuberculosis: reducing costs and diagnostic delay.: Int J Tuberc Lung Dis. 2000 Mar;4(3):240-5. Unique Identifier : AIDSLINE MED/20213122; Hudson CP; Wood R; Maartens G; Department of Medicine, University of Cape Town, South Africa.; SETTING: University-affiliated hospital in South Africa . OBJECTIVE: To assess the time to diagnosis and the yield and laboratory cost of diagnostic procedures in human immunodeficiency virus (HIV) associated tuberculosis. DESIGN: Cohort study. PATIENTS: Adult HIV-infected patients
HIV heterosexual transmission: a hypothesis about an additional potential determinant.: Int J Infect Dis. 2000;4(2):110-6. Unique Identifier : AIDSLINE MED/20202822; Louria DB; Skurnick JH; Palumbo P; Bogden JD; Rohowsky-Kochan C; Denny TN; Kennedy CA; Departments of Preventive Medicine and Community Health, New; Jersey Medical School, Newark, NJ 07103, USA. louriado@umdnj.edu; Transmission rates of human immunodeficiency virus (HIV) during heterosexual intercourse vary dramatically around the world. In Asia and South America, they are extraordinarily high, whereas in the United States and Europe, rates are much lower even after a large number of unprotected
Risk of transfusion-transmitted human T-cell lymphotropic virus-type I in Latin America [editorial]: Int J Infect Dis. 2000;4(2):59-61. Unique Identifier : AIDSLINE MED/20202811; Gotuzzo E; Universidad Peruana Cayetano Heredia, Instituto De Medicina; Tropical Alexander Von Humboldt, Lima, Peru. EGOTUZZO@am.pnu.com; In a recent publication, G. Schmunis et al presented data from Latin America on blood quality and on important approaches to preventing human immmunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), and other infectious diseases that may be transmitted by blood transfusion. Mass screening between 1987
Ten-year review of invasive pneumococcal diseases in children and adults from Uruguay: clinical spectrum, serotypes, and antimicrobial resistance.: Int J Infect Dis. 2000;4(2):91-5. Unique Identifier : AIDSLINE MED/20202817; Hortal M; Camou T; Palacio R; Dibarboure H; Garcia A; Departamento de Laboratorios de Salud, Ministerio de Salud; Publica, Uruguay. mhortal@st.com.uy; OBJECTIVES: Since 1987, the Reference Laboratory of the Ministry of Health of Uruguay has been monitoring infections due to Streptococcus pneumoniae in patients under 5 years of age, in those between 5 to 14 years of age, and in adults. The purpose of the present study was to retr
[Evaluation of outpatient care for people with HIV/AIDS in Rio de Janeiro, from the user's perspective]: Cad Saude Publica. 1999 Oct-Dec;15(4):789-97. Unique Identifier : AIDSLINE MED/20100894; Gomes R; Silva CM; Deslandes SF; Souza ER; Instituto Fernandes Figueira, Fundacao Oswaldo Cruz, Av. Rui; Barbosa, 716, 2 andar, Flamengo, Rio de Janeiro, RJ 22250-020,; Brasil.; This article analyzes perceptions by people with HIV/AIDS towards five specialized units under the State Health Department, Rio de Janeiro, concerning the care provided there. The research was based on both quantitative and qualitative methods. Data from 228 questionnaires and 19 semi-structured interviews were analyz
Vaccine adverse events in the new millennium: is there reason for concern?: Bull World Health Organ. 2000;78(2):205-15. Unique Identifier : AIDSLINE MED/20207689; Ward BJ; McGill Center for Tropical Diseases, Montreal General Hospital,; Quebec, Canada. cybj@musica.mcgill.ca; As more and more infectious agents become targets for immunization programmes, the spectrum of adverse events linked to vaccines has been widening. Although some of these links are tenuous, relatively little is known about the immunopathogenesis of even the best characterized vaccine-associated adverse events (VAAEs).
Reducing HIV/AIDS risk, impact and vulnerability [editorial]: Bull World Health Organ. 2000;78(2):236-7. Unique Identifier : AIDSLINE MED/20207699; Tarantola D
Biomedical and development paradigms in AIDS prevention.: Bull World Health Organ. 2000;78(2):267-73. Unique Identifier : AIDSLINE MED/20207703; Wolffers I; Faculty of Medicine, Free University, Amsterdam, Netherlands.; i.wolffers.social@med.vu.nl; In the fight against the HIV/AIDS pandemic different approaches can be distinguished, reflecting professional backgrounds, world views and political interests. One important distinction is between the biomedical and the development paradigms. The biomedical paradigm is characterized by individualization and the concep
[A case with HTLV-I associated myelopathy (HAM) accompanied by primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH)]: Rinsho Shinkeigaku. 1999 Nov;39(11):1132-4. Unique Identifier : AIDSLINE MED/20154525; Nagami S; Konisi T; Kataoka H; Kikui S; Takayanagi T; Suzumura A; Department of Neurology Kisiwada City Hospital.; We reported a 60-year-old female patient with HTLV-I associated myelopathy (HAM) accompanied by primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH). The diagnosis of PBC and AIH was confirmed by liver biopsy. HAM is considered to be mediated by cellular immune mechanisms, while humoral immune mechanisms may
An indicator cell assay for T-cell tropic, macrophage-tropic, and primary isolates of HIV-1 based on green fluorescent protein.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):213-20. Unique Identifier : AIDSLINE MED/20231109; Dorsky DI; Harrington RD; Division of Infectious Diseases, University of Connecticut Health; Center, Farmington 06030-3212, USA.; Quantitation of HIV-1 in blood is now widely used by clinicians to manage antiviral therapy. Current methods to detect viral RNA are expensive, have slow turnaround times, and do not directly quantitate infectious particles. Indicator cell assay (ICA) methods for titering HIV-1 rely on the activation of HIV-1 long ter
Monoclonal antibodies to an HIV-1 group O envelope recombinant.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):221-7. Unique Identifier : AIDSLINE MED/20231110; Scheffel JW; Ziemann R; Hawksworth D; Tyner J; Hickman RK; Hackett J Jr; Hybridoma Development and Sourcing, Abbott Laboratories, Abbott; Park, Illinois 60064, USA.; Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envel
Cytomegalovirus retinitis in advanced HIV-infected patients treated with protease inhibitors: incidence and outcome over 2 years.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):228-34. Unique Identifier : AIDSLINE MED/20231111; Labetoulle M; Goujard C; Frau E; Rogier H; Niessen F; Furlan V; Lantz O; Lecointe D; Delfraissy JF; Offret H; Department of Ophthalmology, Hopital de Bicetre, Assistance; Publique-Hopitaux de Paris, Le Kremlin-Bicetre, France.; We prospectively studied the incidence of cytomegalovirus ( CMV ) retinitis in 93 patients treated with highly active antiretroviral therapy (HAART) containing a protease inhibitor (PI), during a median follow-up period of 24 m
Treatment of AIDS-related cutaneous Kaposi's sarcoma with topical alitretinoin (9-cis-retinoic acid) gel. Panretin Gel North American Study Group.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):235-46. Unique Identifier : AIDSLINE MED/20231112; Walmsley S; Northfelt DW; Melosky B; Conant M; Friedman-Kien AE; Wagner B; Division of Infectious Diseases, Toronto Hospital, University of; Toronto, Ontario, Canada. sharon.walmsley@uhn.on.ca; BACKGROUND: Kaposi s sarcoma (KS) is the most frequent malignancy in patients with HIV. Given the promise that retinoids show in the treatment of various hyperproliferative skin disorders and in vitro evidence of inhibition of proliferation of KS cells, a randomized, controlled clinical trial was conducted. METHODS AN
Adherence to colposcopy among women with HIV infection.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):247-52. Unique Identifier : AIDSLINE MED/20231113; Cejtin HE; Komaroff E; Massad LS; Korn A; Schmidt JB; Eisenberger-Matiyahu D; Stier E; Department of Obstetrics and Gynecology, Cook County Hospital,; Chicago, Illinois, USA. hcejtin@ameritech.net; In the general population, nonadherence to the recommendation to have colposcopy in women with abnormal cytologic smears is estimated at 30% to 80%, but studies have failed to identify consistent risk factors for nonadherence. The purpose of this analysis is to assess adherence to colposcopy in a subset of participant
Randomized, controlled trial of caloric supplements in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):253-9. Unique Identifier : AIDSLINE MED/20231114; Gibert CL; Wheeler DA; Collins G; Madans M; Muurahainen N; Raghavan SS; Bartsch G; Veteran Affairs Medical Center, Washington Regional AIDS Program,; DC 20422, USA. gibert.c@washington.va.gov; OBJECTIVE: To compare the efficacy of three nutritional regimens in the prevention of weight loss. DESIGN: A three-arm randomized controlled trial with primary outcome measure percent change in weight over four months. PATIENTS: A total of 536 patients with CD4 count
Meta-analysis of two randomized controlled trials comparing combined zidovudine and didanosine therapy with combined zidovudine, didanosine, and nevirapine therapy in patients with HIV. INCAS study team.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):260-6. Unique Identifier : AIDSLINE MED/20231115; Raboud JM; Rae S; Vella S; Harrigan PR; Bucciardini R; Fragola V; Ricciardulli D; Montaner JS; Department of Health Care and Epidemiology, University of British; Columbia, Vancouver, Canada. jraboud@hivnet.ubc.ca; OBJECTIVES: To extend the range of CD4 counts in which a plasma viral load nadir (pVL)
CCR2B-64I chemokine receptor allele and mother-to-child HIV-1 transmission or disease progression in children. French pediatric HIV infection study group.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):267-71. Unique Identifier : AIDSLINE MED/20231116; Teglas JP; N'Go N; Burgard M; Mayaux MJ; Rouzioux C; Blanche S; Delfraissy JF; Misrahi M; Institut National de la Sante et de la Recherche Medicale; (INSERM), Unite 292, Public Health, Epidemiology, and Human; Reproduction, France.; The beneficial role of a variant of the chemokine receptor CCR2B (CCR2B-641) in the evolution of HIV-1 infection in adults is still controversial. Furthermore, no studies have been performed in HIV-1-infected children. A multicenter and prospective study of 745 infants born to HIV-1-seropositive mothers was performed.
Evaluation of a statewide non-name-based HIV surveillance system.: Unique Identifier : AIDSLINE MED/20231117; Solomon L; Flynn C; Eldred L; Caldeira E; Wasserman MP; Benjamin G; Recent advances in AIDS-related therapies have delayed the onset of AIDS-defining illnesses and reduced the usefulness of AIDS surveillance in assessing the incidence of early HIV disease and estimating future needs of the HIV-infected population. These changes have prompted renewed interest in expanding surveillance
Modeling HIV risk.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):280-7. Unique Identifier : AIDSLINE MED/20231118; Bell DC; Trevino RA; Affiliated Systems Corporation, Houston, Texas, USA.; dbell@affiliatedsystems.com; OBJECTIVE: To provide HIV risk estimates for specific local population subgroups using an HIV risk index combining HIV risk behaviors, prevalence rates, and transmission probabilities. METHODS: A sample of 270 individuals was studied. Respondents described sexual and injection risk behaviors and partners in the previo
HIV-1 subtyping in Salvador, Bahia, Brazil: a city with African sociodemographic characteristics.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):288-93. Unique Identifier : AIDSLINE MED/20231119; Couto-Fernandez JC; Morgado MG; Bongertz V; Tanuri A; Andrade T; Brites C; Galvao-Castro B; Advanced Laboratory of Public Health-LASP, Goncalo Moniz; Research Center-CPqGM, Oswaldo Cruz Foundation, UNAIDS; Collaborating Center, Salvador, Bahia.; coutofer@gene.dbbm.fiocruz.br; To investigate the prevalence of the HIV-1 subtypes in different populations from Salvador, Bahia, Brazil , blood samples from 72 HIV-1-seropositive injecting drug users (IDUs) and 62 individuals infected sexually were analyzed using the heteroduplex mobility assay (HMA). In the IDU
Sexual behaviors and other HIV risk factors in circumcised and uncircumcised men in Uganda.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):294-301. Unique Identifier : AIDSLINE MED/20231120; Bailey RC; Neema S; Othieno R; Division of Epidemiology and Biostatistics, School of Public; Health, University of Illinois at Chicago, 60302, USA.; rcbailey@uic.edu; OBJECTIVE: To study the differences in sexual practices, hygienic behaviors, and other HIV risk factors between circumcised and uncircumcised men. DESIGN: A cross-sectional study of men >17 years of age selected by single stage cluster sampling in the Industrial Borough, Mbale, Uganda
Gender difference in skin reactivity to purified protein derivative among carriers of HTLV-I in Japan.: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):302-7. Unique Identifier : AIDSLINE MED/20231121; Hisada M; Stuver SO; Okayama A; Mueller NE; Department of Epidemiology, Harvard School of Public Health,; Boston, Massachusetts, USA. mh280i@nih.gov; The incidence of malignancies due to oncogenic virus infections tends to be higher in men than in women. Gender-related differences in cell-mediated immunity, which plays a role in viral pathogenesis, may explain this observation. To explore this possibility in the context of HTLV-I infection, we examined skin reactiv
Interferon plus ribavirin in HIV-infected patients with chronic hepatitis C [letter]: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):308-9. Unique Identifier : AIDSLINE MED/20231122; Perez-Olmeda M; Gonzalez J; Garcia-Samaniego J; Arribas JR; Pena JM; Soriano V
Effects of high-dose intravenous immunoglobulin on virus load in HIV-infected children [letter]: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):309-11. Unique Identifier : AIDSLINE MED/20231123; Church JA; Fox S; Gomperts E
Risk of HHV-6A primary and recurrent infections during the course of AIDS [letter]: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):311-2. Unique Identifier : AIDSLINE MED/20231124; Ongradi J; Marodi CL; Nagy K; Csiszar A; Banhegyi D; Horvath A
Substantial decrease in numbers and rates of AIDS deaths over the last decade [letter]: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):312-4. Unique Identifier : AIDSLINE MED/20231125; Barkan SE; Leonetti AM; Hopkins SG; Duchin JS
Seroprevalence of HTLV-I/II antibodies in blood donors and different groups at risk in Tunisia [letter]: J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):314-5. Unique Identifier : AIDSLINE MED/20231126; Mojaat N; Kaabi H; Hmida S; Maamar M; Slama S; Boukef K
Turning a corner on HIV neutralization?: Microbes Infect. 2000 Feb;2(2):213-21. Unique Identifier : AIDSLINE MED/20209687; Nunberg JH; Follis KE; Trahey M; LaCasse RA; Montana Biotechnology Center, The University of Montana,; Missoula, MT 59812, USA.; HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using fusion-competent immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this go
Primate models of AIDS.: Microbes Infect. 2000 Feb;2(2):223-9. Unique Identifier : AIDSLINE MED/20209688; Joag SV; JODI Research Inc., Wexford, Pennsylvania and the Marion Merrell; Dow Laboratory of Viral Pathogenesis, University of Kansas School; of Medicine, Kansas, City, Kansas, USA.; The primate models of AIDS provide insights into pathogenesis, transmission, and immune responses to infection and are useful in testing vaccines and drugs. The HIV-1/chimpanzee, SIV(mac)/macaque, and SHIV/macaque models are the most widely used. The advantages and drawbacks of these and other models are discussed.
IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice.: Am J Physiol Lung Cell Mol Physiol. 2000 Apr;278(4):L667-74. Unique Identifier : AIDSLINE MED/20215252; van Scott MR; Justice JP; Bradfield JF; Enright E; Sigounas A; Sur S; Department of Physiology, East Carolina University, Greenville,; North Carolina 27858, USA. mrvanscott@brody.med.ecu.edu; We investigated the effects of interleukin (IL)-10 administration on allergen-induced Th2 cytokine production, eosinophilic inflammation, and airway reactivity. Mice were sensitized by intraperitoneal injection of ragweed (RW) adsorbed to Alum and challenged by intratracheal instillation of the allergen. Sensitization
Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury.: Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R1005-18. Unique Identifier : AIDSLINE MED/20215213; Fukuzuka K; Edwards CK 3rd; Clare-Salzler M; Copeland EM 3rd; Moldawer LL; Mozingo DW; Department of Surgery, University of Florida College of Medicine,; Gainesville, Florida 32610, USA.; Immune suppression and increased apoptotic loss of circulating lymphocytes have been reported after burn injury. However, little is known about the underlying mechanisms responsible for the increased apoptosis of lymphoid and parenchymal cells in solid organs and the role played by inflammatory mediators, such as tumo
Non-HIV lentiviral vectors: interview with Alan Kingsman.: J Gene Med. 1999 Nov-Dec;1(6):441-3. Unique Identifier : AIDSLINE MED/20214744; Kingsman A
Efficient split synthesis for targeted libraries.: J Comb Chem. 2000 Jan-Feb;2(1):10-8. Unique Identifier : AIDSLINE MED/20214068; Cohen B; Skiena S; Department of Computer Science, State University of New York at; Stony Brook 11794-4400, USA.; We propose a new approach for fabricating more sophisticated combinatorial chemistry libraries via split synthesis and evaluate its potential through extensive simulation. Our algorithmically intensive method promises to reduce the time and materials costs of synthesizing libraries which are (1) too large to synthesiz
Antiretroviral therapy in HIV/AIDS: update from San Francisco [editorial]: AIDS Read. 2000 Mar;10(3):133-4. Unique Identifier : AIDSLINE MED/20217390; Laurence J
The Seventh Conference on Retroviruses and Opportunistic Infections.: AIDS Read. 2000 Mar;10(3):135-9. Unique Identifier : AIDSLINE MED/20217391; Merrick S; Gulick R; Boyle B; Weill Medical College of Cornell University, New York, USA.
Addressing the issue of childbearing in heterosexual couples discordant for HIV.: AIDS Read. 2000 Mar;10(3):144-5. Unique Identifier : AIDSLINE MED/20217392; Ball SC; Department of Medicine, New York Presbyterian Hospital-Weill; Medical College of Cornell University, New York, USA.
Adult AIDS Clinical Trials Group funding is renewed [news]: Unique Identifier : AIDSLINE MED/20217393
HHS award $527 million for AIDS CARE [news]: AIDS Read. 2000 Mar;10(3):147. Unique Identifier : AIDSLINE MED/20254514
HIV prevention grants available [news]: AIDS Read. 2000 Mar;10(3):147. Unique Identifier : AIDSLINE MED/20217394
HIV receptor gene is patented [news]: AIDS Read. 2000 Mar;10(3):147. Unique Identifier : AIDSLINE MED/20254513
Sustiva granted full FDA approval [news]: AIDS Read. 2000 Mar;10(3):147. Unique Identifier : AIDSLINE MED/20254515
National urine-based HIV and STD testing service [news]: AIDS Read. 2000 Mar;10(3):147, 149. Unique Identifier : AIDSLINE MED/20254516
Sit out the silly season?: AIDS Read. 2000 Mar;10(3):148-9. Unique Identifier : AIDSLINE MED/20217395; Gebbie KM; Center for Health Policy and Health Services Research, Columbia; University School of Nursing, New York, USA.
Glaxo supports in-prison programs [news]: AIDS Read. 2000 Mar;10(3):149. Unique Identifier : AIDSLINE MED/20254517
HIV drug resistance testing [news]: AIDS Read. 2000 Mar;10(3):149. Unique Identifier : AIDSLINE MED/20254519
HIV reference laboratory opens in Botswana [news]: AIDS Read. 2000 Mar;10(3):149. Unique Identifier : AIDSLINE MED/20254518
When and where to start: guidelines for the initiation of antiretroviral therapy.: AIDS Read. 2000 Mar;10(3):150-5; discussion 171-4. Unique Identifier : AIDSLINE MED/20217396; Volberding P; Center for AIDS Research, University of California, San; Francisco, USA.; Although several sets of treatment guidelines recommend when antiretroviral therapy should begin, no overall consensus has emerged. Factors that must be weighed in deciding when to start include not only CD4+ cell count and viral load but also the stage and tempo of the disease and the commitment of the patient. Evide
When to switch and what to switch to: strategic use of antiretroviral therapy.: AIDS Read. 2000 Mar;10(3):156-61; discussion 171-4. Unique Identifier : AIDSLINE MED/20217397; Gulick R; Cornell Clinical Trials Unit, Weill Medical College of Cornell; University, New York, USA.; Clinical cohort studies suggest that as many as 60% of patients experience virologic failure of a first-line antiretroviral regimen. Second-line and rescue (or salvage) regimens have a poorer success record: Most studies presented to date show a short-term virologic response rate of only approximately 30% in treatment
How to manage metabolic complications of HIV therapy: what to do while we wait for answers.: AIDS Read. 2000 Mar;10(3):162-9; discussion 171-4. Unique Identifier : AIDSLINE MED/20217398; Currier JS; Department of Medicine, University of California, Los Angeles,; USA.; Although effective treatment of antiretroviral-associated metabolic abnormalities ultimately depends on understanding the mechanisms involved, clinicians facing these problems are beginning to feel compelled to do something now to manage treatment-related metabolic complications. Diet and exercise should not be overlo
Adherence to combination antiretroviral therapy: synthesis of the literature and clinical implications.: AIDS Read. 2000 Mar;10(3):177-85. Unique Identifier : AIDSLINE MED/20217404; Miller LG; Hays RD; University of California, Los Angeles (UCLA), School of Medicine,; USA.; Adherence to combination antiretroviral therapy has a strong impact on virologic response and emergence of viral resistance. However, monitoring adherence in the clinic is difficult. What a patient says or a clinician believes about a patient s adherence may be misleading. Patients with suboptimal adherence may have r
Outcomes associated with delirium in acutely hospitalized acquired immune deficiency syndrome patients.: Compr Psychiatry. 2000 Mar-Apr;41(2):88-91. Unique Identifier : AIDSLINE MED/20203928; Uldall KK; Harris VL; Lalonde B; Department of Psychiatry and Behavioral Sciences, School of; Medicine, University of Washington, Seattle, USA.; The study demonstrates that delirium in acquired immune deficiency syndrome (AIDS) patients is associated with mortality, the need for long-term care, and an increased length of hospitalization. Data were collected prospectively on human immunodeficiency virus (HIV)/AIDS patients admitted to a teaching hospital from J
Interactions of antineoplastic chemotherapy with zidovudine pharmacokinetics in patients with HIV-related neoplasms.: Chemotherapy. 1999 Nov-Dec;45(6):418-28. Unique Identifier : AIDSLINE MED/20036386; Toffoli G; Errante D; Corona G; Vaccher E; Bertola A; Robieux I; Aita P; Sorio R; Tirelli U; Boiocchi M; Division of Experimental Oncology 1, Centro di Riferimento; Oncologico, Aviano, Italy.; To evaluate the perturbations in zidovudine (ZDV) pharmacokinetics as a consequence of antineoplastic chemotherapeutic treatments, we performed a prospective crossover study in 13 HIV-infected patients with cancer. The subjects received 2-day regimens of ZDV (250 mg x 2/day). On the first day ZDV was administered alon
Isoniazid plus sulphadoxine-pyrimethamine can reduce morbidity of HIV-positive patients treated for tuberculosis in Africa: a controlled clinical trial.: Chemotherapy. 1999 Nov-Dec;45(6):452-65. Unique Identifier : AIDSLINE MED/20036390; Haller L; Sossouhounto R; Coulibaly IM; Dosso M; Kone M; Adom H; Meyer UA; Betschart B; Wenk M; Haefeli WE; Lobognon LR; Porquet M; Kabore G; Sorenson F; Reber-Liske R; Sturchler D; Roche African Research Foundation, UTH Treichville, Abidjan,; Cote d'Ivoire.; An annual 20% excess mortality rate is observed in HIV-seropositive patients after treatment for tuberculosis. An affordable secondary prophylaxis against main opportunistic diseases is needed, i.e. against tuberculosis, toxoplasmosis, pneumocystosis and other infections occurring in this target population. This open
Pharmacokinetics, biliary excretion, and tissue distribution of novel anti-HIV agents, cosalane and dihydrocosalane, in Sprague-Dawley rats.: Drug Metab Dispos. 2000 Apr;28(4):403-8. Unique Identifier : AIDSLINE MED/20191717; Kuchimanchi KR; Udata C; Johnston TP; Mitra AK; Division of Pharmaceutical Sciences, School of Pharmacy,; University of Missouri-Kansas City, Kansas City, Missouri 64110,; USA.; Cosalane and dihydrocosalane are potent inhibitors of HIV replication with a broad range of activity. The purpose of this study was to investigate: 1) the pharmacokinetic disposition of both cosalane and dihydrocosalane in male Sprague-Dawley rats, and 2) biliary excretion, enterohepatic circulation, and tissue distri
Route-dependent nonlinear pharmacokinetics of a novel HIV protease inhibitor: involvement of enzyme inactivation.: Drug Metab Dispos. 2000 Apr;28(4):460-6. Unique Identifier : AIDSLINE MED/20191724; Lin JH; Chen IW; Chiba M; Nishime JA; Deluna FA; Drug Metabolism, Merck Research Laboratories, West Point,; Pennsylvania 19486, USA. jiunn_lin@merck.com; L-754,394, a furanopyridine derivative, is an experimental HIV protease inhibitor. Previous studies from this laboratory have demonstrated that L-754,394 is cleared very rapidly in animals, and that this drug is a potent mechanism-based inactivator (suicide inhibitor) for CYP3A4 in human liver microsomes. Because L-75
Drug abuse treatment as an HIV prevention strategy: a review.: Drug Alcohol Depend. 2000 Apr 1;59(1):17-31. Unique Identifier : AIDSLINE MED/20173643; Sorensen JL; Copeland AL; Department of Psychiatry, Room 2117, Ward 21, Building 20, UCSF; at San Francisco General Hospital, 1001 Potrero Avenue, San; Francisco, CA 94110, USA. james@itsa.ucsf.edu; We review drug abuse treatment as a means of preventing infection with HIV. Thirty-three studies, with an aggregate of over seventeen thousand subjects, were published in peer-reviewed journals from 1988-1998. Research on the utility of drug abuse treatment as an HIV prevention strategy has focused primarily on methad
[Mycobacterium avium infections in poultry--a risk for human health or not?]: DTW Dtsch Tierarztl Wochenschr. 2000 Feb;107(2):53-8. Unique Identifier : AIDSLINE MED/20207737; Martin G; Schimmel D; Bundesinstitut fur gesundheitlichen Verbraucherschutz und; Veterinarmedizin, Fachbereich, Jena.; Avian tuberculosis is an animal disease notifiable for statistical purposes in Germany . Cases notified (between 130 and 230 annually) were primarily related to private flocks of pedigree poultry and layers consisting of less than 20 animals and individual animals in game enclosure
Drug-resistant tuberculosis: what do we do now?: Drugs. 2000 Feb;59(2):171-9. Unique Identifier : AIDSLINE MED/20192786; Telenti A; Iseman M; Division of Infectious Diseases and Institute of Microbiology,; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; amalio.telenti@chuv.hospvd.ch; Drug-resistant tuberculosis (TB) represents a threat to TB control programmes. Erratic and inappropriate use of currently available medications, HIV-TB co-infection, and concern about transmission of drug-resistant strains in the general population all contribute to a worrying picture. What do we do now? In the last f
Acanthamoeba sinusitis with subsequent dissemination in an AIDS patient.: Ear Nose Throat J. 2000 Mar;79(3):168, 171-4. Unique Identifier : AIDSLINE MED/20208165; Kim SY; Syms MJ; Holtel MR; Nauschuetz KK; Department of Surgery, Madigan Army Medical Center, Tacoma,; Wash., USA. SYMSM001@hawaii.rr.com; Otolaryngologists can play an important role in the care of patients with acquired immunodeficiency syndrome (AIDS) and/or human immunodeficiency virus infection. We present the case of an AIDS patient who was hospitalized for dehydration and who was soon found to have sinusitis and subsequent disseminated infection c
Determination of drug susceptibility and DNA fingerprint patterns of clinical isolates of Mycobacterium tuberculosis from Kampala, Uganda.: East Afr Med J. 2000 Feb;77(2):111-5. Unique Identifier : AIDSLINE MED/20235900; Joloba ML; Whalen CC; Cave DM; Eisenach KD; Johnson JL; Okwera A; Morrissey A; Bajaksouzian S; Feagin J; Mugerwa R; Ellner J; Jacobs MR; Makerere University Medical School, Kampala, Uganda.; OBJECTIVE: To ascertain the rate of initial drug resistance and transmission patterns of Mycobacterium tuberculosis in Kampala, Uganda . SETTING: National Tuberculosis (TB) Treatment Centre, Mulago Hospital, Kampala, Uganda and Case Western Reserve University, Cleveland, Ohio, USA a
Generational differences in male sexuality that may affect Zimbabwean women's risk for sexually transmitted diseases and HIV/AIDS.: East Afr Med J. 2000 Feb;77(2):93-7. Unique Identifier : AIDSLINE MED/20235897; Olayinka BA; Alexander L; Mbizvo MT; Gibney L; UCLA Drug Abuse Research Center 90025, USA.; OBJECTIVE: To determine generational differences in male sexuality, which could predispose men s female sexual partners to STDs/HIV. DESIGN: Cross-sectional study. SETTING: Harare, Zimbabwe . SUBJECTS: Three hundred and ninety seven male adults aged eighteen years and above. MAIN
Ganciclovir implant: clinicopathological study [letter]: Eye. 2000 Feb;14 ( Pt 1):110-2. Unique Identifier : AIDSLINE MED/20217921; al-Yousuf NH; Dhillon B; Ironside J
Decreased visual acuity in patients with cytomegalovirus retinitis and AIDS.: Eye. 2000 Feb;14 ( Pt 1):8-12. Unique Identifier : AIDSLINE MED/20217894; Raina J; Bainbridge JW; Shah SM; St Bartholomew's Hospital, London, UK.; PURPOSE: To investigate the causes of decreased visual acuity in patients with cytomegalovirus ( CMV ) retinitis in the acquired immunodeficiency syndrome (AIDS). METHODS: All human immunodeficiency virus (HIV)-positive patient
Endoscopy in acquired immunodeficiency syndrome patients with diarrhea and negative stool studies.: Gastrointest Endosc. 2000 Apr;51(4 Pt 1):427-32. Unique Identifier : AIDSLINE MED/20209214; Wei SC; Hung CC; Chen MY; Wang CY; Chuang CY; Wong JM; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, Taiwan.; BACKGROUND: Diarrhea is a frequent gastrointestinal symptom in patients with acquired immuno-deficiency syndrome (AIDS) and is a major source of morbidity and mortality. A stepwise diagnostic approach is often recommended to search for treatable causes. However, whether the stepwise diagnostic approach is adequate for
Combination therapy of hepatitis B [comment]: Gut. 2000 Apr;46(4):450-1. Unique Identifier : AIDSLINE MED/20181788; Doo E; Hoofnagle JH; Liver Diseases Section Digestive Diseases Branch National; Institute of Diabetes and Digestive and Kidney Diseases Building; 10, Room 9B06 NIH, Bethesda, MD 20892, USA.; DooE@intra.niddk.nih.gov
Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial [see comments]: Gut. 2000 Apr;46(4):562-8. Unique Identifier : AIDSLINE MED/20181807; Schalm SW; Heathcote J; Cianciara J; Farrell G; Sherman M; Willems B; Dhillon A; Moorat A; Barber J; Gray DF; Department of Hepatology and Gastroenterology, Erasmus University; Hospital Rotterdam, Rotterdam, Netherlands.; BACKGROUND, AIM, AND METHODS: Alpha interferon is the generally approved therapy for HBe antigen positive patients with chronic hepatitis B, but its efficacy is limited. Lamivudine is a new oral nucleoside analogue which potently inhibits hepatitis B
Breast-feeding and human immunodeficiency virus.: Indian J Pediatr. 1997 Jul-Aug;64(4):547-53. Unique Identifier : AIDSLINE MED/20234381; Sharma UK; Willingham FF; Department of Molecular Microbiology and Immunology, Johns; Hopkins University, School of Hygiene and Public Health,; Baltimore, MD 21205, USA.; Breast-feeding provides nutritional, immunological, and psychological benefits. It protects children from mortality and morbidity associated with diarrheal diseases, pneumonia and other infections. Breast feeding has also been shown to prolong the interval between births and thereby improve child survival and maternal
Prevalence of HHV-8 infection among cancer patients in Sicily [letter]: Int J Cancer. 2000 May 1;86(3):448-9. Unique Identifier : AIDSLINE MED/20225796; Serraino D; Bordonaro R; Failla G; De Paoli P; Colina P; Tedeschi RM; Ippolito G
Measurement of anti-human cytomegalovirus T cell reactivity in transplant recipients and its potential clinical use: a mini-review.: Intervirology. 1999;42(5-6):322-4. Unique Identifier : AIDSLINE MED/20169289; Kern F; Faulhaber N; Khatamzas E; Frommel C; Ewert R; Prosch S; Volk H; Reinke P; Institut fur Medizinische Immunologie, Charite (Medizinische; Fakultat der Humboldt-Universitat zu Berlin), Berlin,; Deutschland. florian.kern@charite.de; By allowing direct determination of the frequencies of antigen-specific memory T cells in peripheral blood, novel techniques based on flow cytometry provide new diagnostic opportunities in various clinical settings, including organ transplantation. While the importance of the T cell compartment for the anti-human
Significance of qualitative polymerase chain reaction combined with quantitation of viral load in the diagnosis and follow-up of cytomegalovirus infection after solid-organ transplantation.: Intervirology. 1999;42(5-6):398-404. Unique Identifier : AIDSLINE MED/20169299; Vanpoucke H; Van Vlem B; Vanholder R; Van Renterghem L; Laboratory Virology, University Hospital, Gent, Belgium.; Quantitative PCR was evaluated in the monitoring of patients with ongoing posttransplantation cytomegalovirus ( CMV ) infection and antiviral therapy, compared to leukoDNAemia and serology. From January 1998 until May 1999, 61
Viral dynamics during active cytomegalovirus infection and pathology.: Intervirology. 1999;42(5-6):405-11. Unique Identifier : AIDSLINE MED/20169300; Emery VC; Department of Virology, Royal Free and University College Medical; School, London, UK. vincent@rfhsm.ac.uk; The central role that cytomegalovirus ( CMV ) load plays in its pathogenesis is being unravelled. In AIDS patients with active CMV replication, many months prior to the development of CMV disease, elevated CMV load in the blood
Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.: J Biol Chem. 2000 Mar 31;275(13):9251-5. Unique Identifier : AIDSLINE MED/20200409; Arion D; Sluis-Cremer N; Parniak MA; Lady Davis Institute for Medical Research and McGill University; AIDS Centre, Sir Mortimer B. Davis-Jewish General Hospital,; Montreal, Quebec H3T 1E2, Canada.; The development of phosphonoformic acid (PFA) resistance against a background of 3 -azido-3 -deoxythymidine ( AZT ) resistance in human immunodeficiency virus type 1 (HIV-1) restores viral sensitivity to AZT. High level AZT resistance requires multiple
Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters.: J Biol Chem. 2000 Mar 31;275(13):9385-9. Unique Identifier : AIDSLINE MED/20200428; Garcia A; Cereghini S; Sontag E; Laboratoire de Signalisation Immuno-Parasitaire, URA CNRS 1960,; Departement d'Immunologie, Institut Pasteur, 75015 Paris,; France.; The transcription factor Sp1 regulates the activity of a large number of eukaryotic gene promoters, including early SV40 and human immunodeficiency virus type 1 (HIV-1). Here, we report that expression of SV40 small tumor antigen (small t) in quiescent CV-1 cells transactivates two Sp1-responsive promoters, including
Quantitative analysis of maedi-visna virus DNA load in peripheral blood monocytes and alveolar macrophages.: J Virol Methods. 2000 Apr;86(1):13-20. Unique Identifier : AIDSLINE MED/20179950; Zhang Z; Watt NJ; Hopkins J; Harkiss G; Woodall CJ; Department of Veterinary Pathology, University of Edinburgh,; Edinburgh, UK. zhidong.zhang@bbsrc.ac.uk; Viral load may be an important indicator of disease progression in sheep infected with maedi-visna virus (MVV). To assess this variable accurately in MVV-infected sheep, a quantitative competitive-polymerase chain reaction (QC-PCR) was developed. A conserved region of the MVV pol gene was selected. The RT-PCR MVV pol
Quantitative evaluation of simian immunodeficiency virus infection using NASBA technology.: J Virol Methods. 2000 Apr;86(1):61-70. Unique Identifier : AIDSLINE MED/20179956; Romano JW; Shurtliff RN; Dobratz E; Gibson A; Hickman K; Markham PD; Pal R; Advanced BioScience Laboratories, Inc., 5510 Nicholson Lane,; Kensington, MD 20895, USA. jromano@ablinc.com; The most commonly used animal model for the study of HIV-1 infection in humans is the infection of non-human primates by simian immunodeficiency virus (SIV). The animal hosts used most frequently are different species of macaques, which are readily infected with SIV, and can therefore be used to study natural infectio
In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans.: J Clin Endocrinol Metab. 2000 Apr;85(4):1648-57. Unique Identifier : AIDSLINE MED/20230980; Giltay EJ; Fonk JC; von Blomberg BM; Drexhage HA; Schalkwijk C; Gooren LJ; Research Institute for Endocrinology, Reproduction, and; Metabolism, University Hospital Vrije Universiteit, Amsterdam,; The Netherlands. giltay@dds.nl; The female predominance in several autoimmune diseases suggests a role for sex steroid hormones in disease susceptibility. We therefore investigated to what extent sex hormones would influence immune responsiveness. We analyzed T helper type 1 (TH1) and type 2 cytokine patterns, chemokine receptor expression (n = 2 x
A revisitation of dental student's attitudes toward individuals with AIDS.: J Dent Educ. 2000 Apr;64(4):298-301. Unique Identifier : AIDSLINE MED/20232567; Cohen LA; Romberg E; Grace E; Department of Oral Health Care Delivery, University of Maryland; Dental School, Baltimore 21201, USA.
Selenium status and the human immunodeficiency virus [letter]: J Am Diet Assoc. 2000 Apr;100(4):418. Unique Identifier : AIDSLINE MED/20230428; Campa A; Shor-Posner G; Baum M
[High-dose intravitreal ganciclovir in CMV retinitis]: J Fr Ophtalmol. 2000 Feb;23(2):123-6. Unique Identifier : AIDSLINE MED/20195655; Cochereau I; Diraison MC; Mousalatti H; Bouyer I; Ren L; Guvenisik N; Hoang-Xuan T; Service d'Ophtalmologie, Hopital Bichat, Paris.; oph.sec@bch.ap-hop-paris.fr; PURPOSE: To assess the efficacy and tolerability of high-dose (2000microg) intravitreous ganciclovir in the maintenance therapy of CMV retinitis in AIDS patients. MATERIAL: and methods: Prospective open study in a single center. The maintenance therapy of CMV re
IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity In vivo.: J Immunol. 2000 Apr 1;164(7):3487-93. Unique Identifier : AIDSLINE MED/20192002; Aung S; Graham BS; Department of Microbiology, Vanderbilt University, School of; Medicine, Nashville, TN 37232, USA.; CTL have evolved two major mechanisms for target cell killing: one mediated by perforin/granzyme secretion and the other by Fas/Fas ligand (L) interaction. Although cytokines are integral to the development of naive CTL into cytolytic effectors, the role of cytokines on mechanisms of CTL killing is just emerging. In t
Positive selection is limited by available peptide-dependent MHC conformations.: J Immunol. 2000 Apr 1;164(7):3519-26. Unique Identifier : AIDSLINE MED/20192007; Stefanski HE; Jameson SC; Hogquist KA; Department of Laboratory Medicine, University of Minnesota,; Minneapolis, MN 55455, USA.; Recent data suggest that the diversity of self peptides presented in the thymus during development contributes to positive selection of a diverse T cell repertoire. We sought to determine whether a previously defined hole in the immunological repertoire could be explained by the absence of an appropriate selecting s
The role of B7 costimulation in CD4/CD8 T cell homeostasis.: J Immunol. 2000 Apr 1;164(7):3543-53. Unique Identifier : AIDSLINE MED/20192010; Yu X; Fournier S; Allison JP; Sharpe AH; Hodes RJ; Experimental Immunology Branch, National Cancer Institute, and; National Institute on Aging, National Institutes of Health,; Bethesda, MD 20892, USA. yux@intra.nei.nih.gov; The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice resulted in marked polyclonal peripheral T cell hyperplasia accompanied by skewing toward an increased proportion of CD8 sin
Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulation.: J Immunol. 2000 Apr 1;164(7):3554-62. Unique Identifier : AIDSLINE MED/20192011; Kato T; Nariuchi H; Department of Allergology, Institute of Medical Science,; University of Tokyo, Tokyo, Japan. kato-tak@ims.u-tokyo.ac.jp; In this study, we examined in vitro the role of CTLA-4 costimulation in the polarization of naive CD4+ T cells toward the Th1 subset. When CTLA-4 costimulation was blocked by the inclusion of anti-CTLA-4 Fab in cultures during priming of naive CD4+ T cells with anti-CD3 in the presence of splenic adherent cells, they
IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis.: J Immunol. 2000 Apr 1;164(7):3563-72. Unique Identifier : AIDSLINE MED/20192012; Young DA; Lowe LD; Booth SS; Whitters MJ; Nicholson L; Kuchroo VK; Collins M; Genetics Institute, Cambridge, MA 02140, USA. dyoung@genetics.com; Experimental autoimmune encephalomyelitis (EAE) is induced in the SJL/J mouse by adoptive transfer of activated proteolipid protein peptide (PLP) 139-151-specific Th1 cells. T cells responding to altered peptide ligands (APL) of PLP, previously shown to induce Th2 differentiation and regulate disease in PLP-immunized
Crucial role of TNF-alpha in CD8 T cell-mediated elimination of 3LL-A9 Lewis lung carcinoma cells in vivo.: J Immunol. 2000 Apr 1;164(7):3645-51. Unique Identifier : AIDSLINE MED/20192022; Prevost-Blondel A; Roth E; Rosenthal FM; Pircher H; Institute of Medical Microbiology and Hygiene, Department of; Immunology, University of Freiburg, Freiburg, Germany.; The role of perforin, IFN-gamma, and TNF-alpha in anti-tumor CD8 T cell immunity was examined in a new tumor model using a CD8 T cell epitope (GP33) derived from lymphocytic choriomeningitis virus as a tumor-associated Ag. In contrast with parental 3LL-A9 (A9) Lewis lung carcinoma cells that progressively grow in C57B
Neonatal administration of IL-12 enhances the protective efficacy of antiviral vaccines.: J Immunol. 2000 Apr 1;164(7):3698-704. Unique Identifier : AIDSLINE MED/20192029; Arulanandam BP; Mittler JN; Lee WT; O'Toole M; Metzger DW; Center for Immunology and Microbial Disease, Albany Medical; College, Albany, NY 12208, USA.; Neonates are highly susceptible to infectious agents and are known to display polarized expression of Th2-like cytokines and Abs. This neonatal immune bias has important implications for the development of vaccine strategies, particularly against viral infections. We now report that coadministration of IL-12 and an in
Direct visualization of cytokine-producing recall antigen-specific CD4 memory T cells in healthy individuals and HIV patients.: J Immunol. 2000 Apr 1;164(7):3723-32. Unique Identifier : AIDSLINE MED/20192032; Helms T; Boehm BO; Asaad RJ; Trezza RP; Lehmann PV; Tary-Lehmann M; Department of Pathology, Case Western Reserve University,; Cleveland, OH 44106, USA.; We have used computer-assisted cytokine ELISA spot analysis to measure the frequencies, the type of cytokine, and the amount of cytokine produced by individual recall Ag-specific CD4 memory cells in freshly isolated blood. We studied the memory cells specific for tetanus toxoid and purified protein derivative in 18 he
Tumor-specific CD4+ T lymphocytes from cancer patients are required for optimal induction of cytotoxic T cells against the autologous tumor.: Unique Identifier : AIDSLINE MED/20192054; Baxevanis CN; Voutsas IF; Tsitsilonis OE; Gritzapis AD; Sotiriadou R; Papamichail M; This study focuses on the specific CD4+ T cell requirement for optimal induction of cytotoxicity against MHC class II negative autologous tumors (AuTu) collected from patients with various types of cancer at advanced stages. CD4+ T cells were induced in cultures of cancer patients malignant effusion-associated mononu
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.: J Immunol. 2000 Apr 1;164(7):3913-8. Unique Identifier : AIDSLINE MED/20192055; Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV; The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Previous work has indicated that an important component for the initiation of autoimmune insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I-restricted CD8 T cell responses against pancreatic beta cell Ags. However, unless previously activated in vitro, such CD8 T cells have previousl
Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA).: Unique Identifier : AIDSLINE MED/20192073; Al-Harthi L; Marchetti G; Steffens CM; Poulin J; Sekaly R; Landay A; Department of Immunology/Microbiology, Rush Presbyterian St.; Luke's Medical Center, 1653 West Congress Parkway, Rm. 1577 JSC,; Chicago, IL 60612, USA. lalharth@rush.edu; Currently, phenotypic markers that distinguish between recent thymic emigrants/de novo T cells and the rest of the peripheral T cell pool are lacking. This distinction is critical in studies aimed at evaluating immune reconstitution following intensive chemotherapy, in immunodeficiency-related therapies, or in the elu
Direct-to-consumer prescription drug advertising, 1989-1998. A content analysis of conditions, targets, inducements, and appeals.: Unique Identifier : AIDSLINE MED/20239110
Common antiviral agents used in women's and children's care, part 2.: J Obstet Gynecol Neonatal Nurs. 2000 Mar-Apr;29(2):191-200. Unique Identifier : AIDSLINE MED/20212723; Burpo RH; Parkland School of Nurse-Midwifery of the Parkland Health and; Hospital System in Dallas, Texas 75235, USA.; Antiviral agents that act in the later phases of the viral reproductive cycle are used primarily against human immunodeficiency virus (HIV). Combination therapy for HIV with drugs from different categories is more effective than monodrug therapy in slowing disease progression and improving survival. Antiviral treatmen
Effect of vitamin A therapy on serologic responses and viral load changes after influenza vaccination in children infected with the human immunodeficiency virus.: J Pediatr. 2000 Apr;136(4):550-2. Unique Identifier : AIDSLINE MED/20216985; Hanekom WA; Yogev R; Heald LM; Edwards KM; Hussey GD; Chadwick EG; Department of Pediatrics, Northwestern University Medical School,; Chicago, IL, USA.; Vitamin A administered to children infected with the human immunodeficiency virus before influenza vaccination in a double-blind randomized study did not enhance vaccine serologic responses but did dampen the increase in the human immunodeficiency virus viral load 14 days after immunization (vitamin A, decrease of 0.1
Paronychia in patients receiving antiretroviral therapy for human immunodeficiency virus infection [letter]: J Am Podiatr Med Assoc. 2000 Feb;90(2):98-100. Unique Identifier : AIDSLINE MED/20163083; Sibel S; Macher A; Goosby E
A simple and rapid technique for the detection of Epstein-Barr virus DNA in HIV-associated oral hairy leukoplakia biopsies.: J Oral Pathol Med. 2000 Mar;29(3):118-22. Unique Identifier : AIDSLINE MED/20201517; Mabruk MJ; Antonio M; Flint SR; Coleman DC; Toner M; Kay E; Leader M; Atkins GJ; Department of Pathology, Royal College of Surgeons in Ireland and; Beaumont Hospital, Dublin.; A method of generating nucleic acid probes by polymerase chain reaction (PCR) for the detection of Epstein-Barr virus (EBV)-DNA by in situ hybridization in oral hairy leukoplakia (OHL) lesions is described. This method has the advantage over older methods of being cheaper, quicker and retaining sensitivity and specifi
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.: J Mol Biol. 2000 Mar 31;297(3):645-57. Unique Identifier : AIDSLINE PDB/1C17; Anderson AC; Perry KM; Freymann DM; Stroud RM; Department of Biochemistry, University of California at San; Francisco, San Francisco, CA, USA.; Thymidylate synthase from Pneumocystis carinii (PcTS) is an especially important drug target, since P. carinii is a fungus that causes opportunistic pneumonia infections in immune-compromised patients and is among the leading causes of death of AIDS patients. Thymidylate synthase (TS) is the sole enzyme responsible fo
The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein.: J Mol Biol. 2000 Apr 7;297(4):877-93. Unique Identifier : AIDSLINE MED/20202370; Zeffmandagger A; Hassarddagger S; Varani G; Lever A; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2; 2QH, United Kingdom.; The major packaging signal of human immunodeficiency virus type 1 (HIV-1) RNA has been localised to the region 3 to the major splice donor within the leader sequence. Secondary structural studies for this region of the HIV-1 genome have shown the existence of a stem-loop structure capped by a purine-rich tetraloop. E
Concurrent neutral evolution of mRNA secondary structures and encoded proteins.: Unique Identifier : AIDSLINE MED/20219317; Konecny J; Schoniger M; Hofacker I; Weitze MD; Hofacker GL; Messenger RNA sequences often have to preserve functional secondary structure elements in addition to coding for proteins. We present a statistical analysis of retroviral mRNA which
The case against anergy testing as a routine adjunct to tuberculin skin testing.: JAMA. 2000 Apr 19;283(15):2003-7. Unique Identifier : AIDSLINE MED/20248531; Slovis BS; Plitman JD; Haas DW; Department of Medicine, Vanderbilt University Medical Center,; Nashville, Tenn, USA.; Although anergy testing is commonly used to help interpret negative tuberculin skin test results, the validity of this approach has not been demonstrated. Specific issues include lack of a standardized protocol for antigen selection, number needed to reliably evaluate inability to respond, and uniform criteria for def
Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma.: Leukemia. 2000 Apr;14(4):716-21. Unique Identifier : AIDSLINE MED/20225230; Bazarbachi A; Nasr R; El-Sabban ME; Mahe A; Mahieux R; Gessain A; Darwiche N; Dbaibo G; Kersual J; Zermati Y; Dianoux L; Chelbi-Alix MK; de The H; Hermine O; Department of Internal Medicine, American University of Beirut,; Lebanon.; The combination of the anti-viral agents, zidovudine ( AZT ) and interferon-alpha (IFN), is a potent treatment of HTLV-I-associated adult T cell leukemia/lymphoma (ATL). In this study we investigate the possible mechanism of action of this combination b
Treatment guidelines for HIV-associated wasting.: Mayo Clin Proc. 2000 Apr;75(4):386-94. Unique Identifier : AIDSLINE MED/20224560; Nemechek PM; Polsky B; Gottlieb MS; Nemechek Health Renewal, Prairie Village, Kan. 66208, USA.; Patients with acquired immunodeficiency syndrome (AIDS) often suffer from weight loss manifested by a loss of body cell mass (BCM). The causes of human immunodeficiency virus (HIV)-associated wasting may include anorexia, malabsorption, and a variety of altered metabolic states. Malabsorption and diarrhea may result f
[HIV infection, quality of life and protease inhibitors (letter; comment)]: Med Clin (Barc). 2000 Feb 12;114(5):196. Unique Identifier : AIDSLINE MED/20203214; Martinez Gonzalez J; Garcia Ordonez MA; Sanchez Simonet MV; Juarez Fernandez C
An unusual case of retinitis.: Lancet. 2000 Mar 18;355(9208):984. Unique Identifier : AIDSLINE MED/20228925; Young S; Bom S; Lightman S; Department of Clinical Ophthalmology, Institute of Ophthalmology; and Moorfields Eye Hospital, London, UK.; stephanie.young@ucl.ac.uk
Aetiology, outcome, and risk factors for mortality among adults with acute pneumonia in Kenya.: Unique Identifier : AIDSLINE MED/20231074; Scott JA; Hall AJ; Muyodi C; Lowe B; Ross M; Chohan B; Mandaliya K; Getambu E; Gleeson F; Drobniewski F
Warsaw conference on emerging infections in central and eastern Europe [news]: Lancet. 2000 Apr 8;355(9211):1246. Unique Identifier : AIDSLINE MED/20231083; Balinska MA
A regional task force on traditional medicine and AIDS.: Lancet. 2000 Apr 8;355(9211):1284. Unique Identifier : AIDSLINE MED/20231108; Bodeker G; Kabatesi D; King R; Homsy J; Green College, University of Oxford, UK.
[Soluble intercellular adhesion molecule-1 (ICAM-1) levels in HIV infected children]: Medicina (B Aires). 1999;59(4):351-4. Unique Identifier : AIDSLINE MED/20215659; Gaddi E; Balbaryski J; Cantisano C; Barboni G; Candi M; Giraudi V; Departamento de Medicina, Hospital General de Ninos Dr. Pedro de; Elizalde, Buenos Aires, Argentina. vgiraudi@intramed.net.ar; Intercellular adhesion molecule-1 (ICAM-1) is a membrane bound molecule that is involved in cell to cell adhesive interactions within the immune system. The aim of this study was to measure the concentrations of soluble ICAM-1 (s-ICAM-1) in 25 HIV-1 infected pediatric patients. We compared s-ICAM-1 values to parameter
In vivo down regulation of HIV replication after hepatitis C superinfection.: Medicina (B Aires). 1999;59(4):364-6. Unique Identifier : AIDSLINE MED/20215661; Flichman D; Cello J; Castano G; Campos R; Sookoian S; Facultad de Farmacia & Bioquimica, Universidad de Buenos Aires,; Argentina.; There are increasing molecular and clinical evidences that the effects of human immunodeficiency virus (HIV) infection can be modified by coinfection with other viruses. The objective was to investigate the viral interaction between HIV and hepatitis C virus (HCV) after HCV superinfection. A 16 year-old pregnant woman
[Current status of the treatment of HIV infection]: Medicina (B Aires). 1999;59(4):385-92. Unique Identifier : AIDSLINE MED/20215666; Suarez CJ; Jahnke N; Montaner JS; Canadian HIV Trial Network, BC Centre for Excellence in HIV/AIDS,; Vancouver, Canada.; The antiretroviral therapeutic strategy changed in 1996, when the prognostic value of the plasma viral load and the CD4 cell counts were confirmed. Two nucleosides, plus a protease inhibitor or a non-nucleoside, are currently the initial preferred options. Viral resistance, and pharmacokinetic problems, however, have
Antenatal screening for HIV in Australia: time to revise policies? [letter]: Med J Aust. 2000 Feb 21;172(4):188-9; discussion 189-90. Unique Identifier : AIDSLINE MED/20233559; Garland SM; Duke JE; Woodhouse DR
Antenatal screening for HIV in Australia: time to revise policies? [letter]: Unique Identifier : AIDSLINE MED/20233560
[New classes of drug for treating HIV infections (news)]: Med Monatsschr Pharm. 2000 Mar;23(3):100-2. Unique Identifier : AIDSLINE MED/20254508
Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy [see comments]: N Engl J Med. 2000 May 4;342(18):1309-15. Unique Identifier : AIDSLINE MED/20239517; Nickeleit V; Klimkait T; Binet IF; Dalquen P; Del Zenero V; Thiel G; Mihatsch MJ; Hirsch HH; Institute for Pathology, University of Basel, Switzerland.; BACKGROUND: Reactivation of polyomavirus type BK (BK virus) is increasingly recognized as a cause of severe renal-allograft dysfunction. Currently, patients at risk for nephropathy due to infection with the BK virus are identified by the presence of cells containing viral inclusion bodies ( decoy cells ) in the urine
Therapeutic dilemma: the use of anticonvulsants in HIV-positive individuals.: Neurology. 2000 Apr 11;54(7):1404-7. Unique Identifier : AIDSLINE MED/20215040; Romanelli F; Jennings HR; Nath A; Ryan M; Berger J; University of Kentucky Medical Center and College of Pharmacy,; Lexington, KY 40536, USA.; ARTICLE ABSTRACT: The concurrent use of anticonvulsants and antiretrovirals is a poorly studied area that poses a therapeutic dilemma for the clinician caring for HIV-positive patients requiring both classes of medications. Anticonvulsants and antiretrovirals may interact through multiple mechanisms including competit
Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins.: Neurology. 2000 Apr 11;54(7):1433-41. Unique Identifier : AIDSLINE MED/20215046; Jorens PG; VanderBorght A; Ceulemans B; Van Bever HP; Bossaert LL; Ieven M; Goossens H; Parizel PM; Van Dijk H; Raus J; Stinissen P; Department of Intensive Care Medicine, University Hospital of; Antwerp, Belgium. philippe.jorens@uza.uia.ac.be; OBJECTIVE: After implicating Streptococcus pyogenes as causing acute disseminated encephalomyelitis (ADEM) in a child, we wanted to prove that in vivo activation of autoreactive T lymphocytes by superantigens of this Streptococcus contributed to the dramatic demyelination. BACKGROUND: ADEM is a demyelinating disorder
The role of somatosensory evoked potentials in the diagnosis of AIDS-associated myelopathy.: Neurology. 2000 Apr 11;54(7):1477-82. Unique Identifier : AIDSLINE MED/20215055; Tagliati M; Di Rocco A; Danisi F; Simpson DM; Department of Neurology, Clinical Neurophysiology, The Mount; Sinai Medical Center, New York, NY 10003, USA.; mtagliat@bethisraelny.org; BACKGROUND: Although AIDS-associated vacuolar myelopathy is detected in >50% of autopsy cases, it is often unrecognized during life. The clinical assessment is often difficult because of concurrent peripheral neuropathy and lack of specific diagnostic markers. Somatos
Detection of N-H...N hydrogen bonding in RNA via scalar couplings in the absence of observable imino proton resonances.: Nucleic Acids Res. 2000 Apr 1;28(7):1585-93. Unique Identifier : AIDSLINE MED/20175723; Hennig M; Williamson JR; Department of Molecular Biology and The Skaggs Institute of; Chemical Biology, The Scripps Research Institute, La Jolla, CA; 92037, USA.; Hydrogen bond networks stabilize RNA secondary and tertiary structure and are thus essentially important for protein recognition. During structure refinements using either NMR or X-ray techniques, hydrogen bonds were usually inferred indirectly from the proximity of donor and acceptor functional groups. Recently, quan
Initiation of translation by non-AUG codons in human T-cell lymphotropic virus type I mRNA encoding both Rex and Tax regulatory proteins.: Nucleic Acids Res. 2000 Apr 1;28(7):1625-34. Unique Identifier : AIDSLINE MED/20175727; Corcelette S; Masse T; Madjar JJ; Laboratoire de Biologie Moleculaire et Cellulaire, INSERM U 369,; Faculte de Medecine Lyon-RTH Laennec, 7 rue Guillaume Paradin,; 69372 Lyon Cedex 08, France.; Human T-cell lymphotropic virus type I (HTLV-I) double-spliced mRNA exhibits two GUG and two CUG codons upstream to, and in frame with, the sequences encoding Rex and Tax regulatory proteins, respectively. To verify whether these GUG and CUG codons could be used as additional initiation codons of translation, two chim
Death of a nation: the AIDS crisis in Zimbabwe.: Pharos. 2000 Winter;63(1):12-5. Unique Identifier : AIDSLINE MED/20215807; Kasambira TS; Tufts University School of Medicine, USA. tkasambi@opal.tufts.edu
Resilience factors associated with adaptation to HIV disease.: Psychosomatics. 2000 Mar-Apr;41(2):140-6. Unique Identifier : AIDSLINE MED/20221905; Farber EW; Schwartz JA; Schaper PE; Moonen DJ; McDaniel JS; Department of Psychiatry and Behavioral Sciences, Emory; University School of Medicine, Atlanta, Georgia, USA.; efarber@emory.edu; This study examines the hardiness dimensions of commitment, challenge, and control as resilience factors in adaptation among persons with symptomatic HIV disease and AIDS. Two hundred participants completed self-report questionnaires measuring hardiness, psychological distress, quality of life, and core personal belie
An evaluation of a self-generated identification code.: Res Nurs Health. 2000 Apr;23(2):167-74. Unique Identifier : AIDSLINE MED/20242969; DiIorio C; Soet JE; Van Marter D; Woodring TM; Dudley WN; Department of Behavioral Sciences and Health Education, Rollins; School of Public Health, Emory University, Atlanta, GA 30322,; USA.; We describe a self-generated coding form used in a study of HIV prevention practices of college students and provide information on the success rate of matching questionnaires over a 3-year period using the form. The data for this study were from a longitudinal study of HIV risk-reduction practices of college students
[AIDS and school: proposal for institutional and interdisciplinary prevention]: Rev Bras Enferm. 1998 Apr-Jun;51(2):245-52. Unique Identifier : AIDSLINE MED/20238598; Carvalho R de O; Depto de Enfermagem Medico-Cirurgica da Faculdade de Enfermagem; da UERJ.; The project AIDS and School emerges as an institutional and interdisciplinary new proposal for HIV/AIDS combat. In 1992, Rio de Janeiro State University represented by Social Work and Nursing Faculties and by Adolescent Health Studies Nucleus and Education and Health State Secretaries and yet Oswaldo Cruz Foundation (
Preferential recruitment of phagocytes into the lung of patients with advanced acquired immunodeficiency syndrome and tuberculosis.: Unique Identifier : AIDSLINE MED/20176941; Werneck-Barroso E; Bonecini-de-Almeida MD; Vieira MA; Carvalho CE; Teixeira AK; Kritski AL; Ho JL; Limited data are available on the cellular and immunocytological characteristics of bronchoalveolar lavage (BAL) fluid in individuals infected with the human immunodeficiency virus (HIV) and pulmonary tuberculosis (TB). The immune host response against tuberculosis in early HIV-infection may differ from that in later
[The morphopathological aspects at autopsy of HIV infection in children]: Rev Med Chir Soc Med Nat Iasi. 1997 Jan-Jun;101(1-2):147-52. Unique Identifier : AIDSLINE MED/20220243; Caruntu ID; Mihaila D; Danciu M; Catedra de Histologie, Facultatea de Medicina, Universitatea de; Medicina si Farmacie Gr. T. Popa, Iasi.; Aspects of HIV infection and AIDS in childhood have been reported since 1982. Pathological features are due to direct action of HIV, opportunistic infection and some tumoral processes. This report presents our own experience resulted from 27 cases of necropsy of patients diagnosed with AIDS or seropositive for HIV. Em
Infectious diseases in rugby players: incidence, treatment and prevention.: Sports Med. 2000 Mar;29(3):211-20. Unique Identifier : AIDSLINE MED/20201876; Stacey A; Atkins B; Microbiology Department, Royal Berkshire and Battle Hospitals NHS; Trust, Reading, England. astacey@phls.nhs.uk; Participation in rugby football can expose individuals to a variety of infectious diseases both on and off the field of play. The close physical contact and trauma inherent in playing rugby facilitates the transmission of viral, bacterial and fungal pathogens between players and may also lead to the acquisition of pot
[Pulmonary pneumocystosis in an HIV-infected subject. Diagnosis, development, treatment and prevention]: Rev Prat. 2000 Jan 15;50(2):217-21. Unique Identifier : AIDSLINE MED/20201336; Beaucaire G; Service de reanimation, CH hopital Gustave-Dron, Tourcoing.
Psychosocial skills training for schizophrenia: lessons from the laboratory.: Schizophr Bull. 2000;26(1):21-46. Unique Identifier : AIDSLINE MED/20216444; Heinssen RK; Liberman RP; Kopelowicz A; Adherence and Behavior Change Research Program, Division of; Mental Disorders, Behavioral Research, and AIDS, National; Institute of Mental Health, Bethesda, MD 20892-9615, USA.; rheinsse@mail.nih.gov; A large body of research supports the efficacy of psychosocial treatments for schizophrenia, particularly learning-based therapies. The Schizophrenia Patient Outcomes Research Team recommended that cognitive-behavioral therapies be used in schizophrenia, and skills training was included in the practice guideline for t
HIV-associated dementia [letter; comment]: Science. 2000 Apr 21;288(5465):440-2. Unique Identifier : AIDSLINE MED/20256118; Major EO; Rausch D; Marra C; Clifford D
South Africa. AIDS researchers decry Mbeki's views on HIV [news]: Science. 2000 Apr 28;288(5466):590-1. Unique Identifier : AIDSLINE MED/20256129; Cohen J
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease [see comments]: Science. 2000 Apr 28;288(5466):669-72. Unique Identifier : AIDSLINE MED/20247435; Cavazzana-Calvo M; Hacein-Bey S; de Saint Basile G; Gross F; Yvon E; Nusbaum P; Selz F; Hue C; Certain S; Casanova JL; Bousso P; Deist FL; Fischer A; INSERM Unit 429, Gene Therapy Laboratory, Cell Therapy; Laboratory, Unite d'Immunologie et d'Hematologie Pediatriques,; Hopital Necker, 75743 Paris Cedex 15, France.; Severe combined immunodeficiency-X1 (SCID-X1) is an X-linked inherited disorder characterized by an early block in T and natural killer (NK) lymphocyte differentiation. This block is caused by mutations of the gene encoding the gammac cytokine receptor subunit of interleukin-2, -4, -7, -9, and -15 receptors, which par
Control of homeostasis of CD8+ memory T cells by opposing cytokines.: Science. 2000 Apr 28;288(5466):675-8. Unique Identifier : AIDSLINE MED/20247437; Ku CC; Murakami M; Sakamoto A; Kappler J; Marrack P; Howard Hughes Medical Institute, Department of Medicine, National; Jewish Medical and Research Center, University of Colorado Health; Sciences Center, Denver, CO 80206, USA.; Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 ( IL-2 ). Therefore,
Mature dendritic cells induce T-helper type-1-dominant immune responses in patients with metastatic renal cell carcinoma.: Urol Int. 2000;63(3):151-9. Unique Identifier : AIDSLINE MED/20204355; Rieser C; Ramoner R; Holtl L; Rogatsch H; Papesh C; Stenzl A; Bartsch G; Thurnher M; Department of Urology, University of Innsbruck, Austria.; We performed a pilot study on a dendritic cell (DC)-based vaccine in 4 patients with advanced renal cell carcinoma. The vaccine consisted of cultured blood DCs loaded with autologous tumor cell lysate plus keyhole limpet hemocyanin (KLH) and matured with a combination of tumor necrosis factor alpha and prostaglandin E
Effect of bovine leukaemia virus on embryonic development and association with in vitro fertilised embryos.: Vet Rec. 2000 Feb 26;146(9):255-6. Unique Identifier : AIDSLINE MED/20199557; Bielanski A; Maxwell P; Simard C; Animal Disease Research Institute, Germplasm Centre of Expertise,; Nepean, Ontario, Canada.
Hearing problems in Mexican American elderly.: Am J Otol. 2000 Mar;21(2):168-72. Unique Identifier : AIDSLINE MED/20195317; Davanipour Z; Lu NM; Lichtenstein M; Markides KS; House Ear Institute, Los Angeles, California, USA.; OBJECTIVE: To investigate hearing problems in a sample of elderly Mexican Americans. STUDY DESIGN: A longitudinal field study of a cohort of 3,050 subjects with in-person baseline and a 2-year follow-up. Population-based, cross-sectional, weighted data were analyzed. SETTINGS AND SUBJECTS: Hispanic Established Populat
Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report.: Unique Identifier : AIDSLINE MED/20239172; Ress BD
Case reports of nocardiosis in patients with human immunodeficiency virus (HIV) infection.: Ann Acad Med Singapore. 2000 Jan;29(1):119-26. Unique Identifier : AIDSLINE MED/20212468; Lee CC; Loo LW; Lam MS; Department of Infectious Disease, Tan Tock Seng Hospital,; Singapore.; INTRODUCTION: We present 4 local cases of nocardiosis in HIV-infected patients and discuss the diagnosis, clinical syndromes and therapy of nocardiosis. CLINICAL PICTURE: Two cases presented with pulmonary nocardiosis, one had a cervical lymph node abscess and one had disseminated nocardiosis with pulmonary, cerebral
Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy.: Antimicrob Agents Chemother. 2000 Apr;44(4):1029-34. Unique Identifier : AIDSLINE MED/20187166; Fletcher CV; Brundage RC; Remmel RP; Page LM; Weller D; Calles NR; Simon C; Kline MW; University of Minnesota Health Sciences Center, Minneapolis, MN; 55455, USA. fletc0012tc.umn.edu; The use of human immunodeficiency virus (HIV) protease inhibitors in children has lagged behind that in adults because of the lack of suitable pediatric formulations and information on safe and effective dosing regimens. This study was designed to obtain pharmacokin
Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group.: Antimicrob Agents Chemother. 2000 Apr;44(4):1041-6. Unique Identifier : AIDSLINE MED/20187168; Hughes WT; Shenep JL; Rodman JH; Fridland A; Willoughby R; Blanchard S; Purdue L; Coakley DF; Cundy KC; Culnane M; Zimmer B; Burchett S; Read JS; St. Jude Children's Research Hospital, Memphis, TN 38105-2794,; USA. walter.hughes@stjude.org; The acyclic phosphonate analog adefovir is a potent inhibitor of retroviruses, including human immunodeficiency virus (HIV) type 1, and, unlike some antiviral nucleosides, does not require the initial phosphorylation step for its activity. Two oral dosages of the adefovir prodrug adefovir dipivoxil were evaluated in a
The triple combination indinavir-zidovudine-lamivudine is highly synergistic.: Antimicrob Agents Chemother. 2000 Apr;44(4):1051-8. Unique Identifier : AIDSLINE MED/20187170; Snyder S; D'Argenio DZ; Weislow O; Bilello JA; Drusano GL; SRA Life Sciences, Rockville, Maryland.; Administration of the combination of indinavir-zidovudine-lamivudine has been demonstrated to cause a large fraction of treated patients to have a decline in human immunodeficiency virus type 1 (HIV-1) copy number to below the detectability of sensitive assays. A recent investigation (G. L. Drusano, J. A. Bilello, D.
Single-dose pharmacokinetics of amprenavir, a human immunodeficiency virus type 1 protease inhibitor, in subjects with normal or impaired hepatic function.: Antimicrob Agents Chemother. 2000 Apr;44(4):821-6. Unique Identifier : AIDSLINE MED/20187135; Veronese L; Rautaureau J; Sadler BM; Gillotin C; Petite JP; Pillegand B; Delvaux M; Masliah C; Fosse S; Lou Y; Stein DS; Laboratoire Glaxo Wellcome, 78163 Marly-le-Roi, France.; lv48262@glaxowellcome.co.uk; Amprenavir (141W94) is extensively metabolized by P450 cytochromes, specifically, CYP3A4. Because hepatic insufficiency reduces P450-mediated metabolism, the concentrations in plasma of drugs metabolized through this pathway are often increased in sub
Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.: Antimicrob Agents Chemother. 2000 Apr;44(4):853-8. Unique Identifier : AIDSLINE MED/20187140; Placidi L; Cretton-Scott E; Gosselin G; Pierra C; Schinazi RF; Imbach JL; el Kouni MH; Sommadossi JP; Department of Pharmacology, University of Alabama at Birmingham,; Birmingham, AL 35294, USA.; The intracellular metabolism of the beta-L- enantiomer of 2 , 3 -dideoxyadenosine (beta-L-ddA) was investigated in HepG2 cells, human peripheral blood mononuclear cells (PBMC), and primary cultured human hepatocytes in an effort to understand the metabolic basis of its limited activity on the replication of human immu
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1.: Antimicrob Agents Chemother. 2000 Apr;44(4):920-8. Unique Identifier : AIDSLINE MED/20187151; Petropoulos CJ; Parkin NT; Limoli KL; Lie YS; Wrin T; Huang W; Tian H; Smith D; Winslow GA; Capon DJ; Whitcomb JM; ViroLogic, Inc., South San Francisco, California 94080, USA.; cpetropoulos@virologic.com; Although combination antiretroviral therapy has resulted in a considerable improvement in the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection, the emergence of resistant virus is a significant obstacle to the effective management of HIV infection and AIDS. We have developed a novel phenotypic
Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers.: Antimicrob Agents Chemother. 2000 Apr;44(4):978-84. Unique Identifier : AIDSLINE MED/20187159; Brophy DF; Israel DS; Pastor A; Gillotin C; Chittick GE; Symonds WT; Lou Y; Sadler BM; Polk RE; Schools of Pharmacy, Virginia Commonwealth University/Medical; College of Virginia Campus, Richmond, VA 23298-0533, USA.; The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balan
Doppler echocardiographic evaluation of HIV-positive patients in different stages of the disease.: Arq Bras Cardiol. 1999 Aug;73(2):157-68. Unique Identifier : AIDSLINE MED/20215645; Werneck GL; Mesquita ET; Romeo Filho LJ; Ribeiro ML; Universidade Federal Fluminense, Rio de Janeiro, Brazil.; OBJECTIVE: To evaluate by Doppler echocardiography (DE) early abnormalities of ventricular function in HIV-positive patients, as well as other cardiac abnormalities that can be detected by this method, with special emphasis on mitral valve flow. METHODS: 84 HIV-positive patients, 59 with CD4 cell count > 500/mm3 (Grou
Cardiac abnormalities in the acquired immunodeficiency syndrome. A prospective study with a clinical-pathological correlation in twenty-one adult patients.: Arq Bras Cardiol. 1999 Sep;73(3):281-90. Unique Identifier : AIDSLINE MED/20215627; Herdy GV; Herdy AH; Almeida PS; de Carvalho R; Azevedo FB; Azevedo K; Vasconcelos MC; Paiva R; Tchou HY; Nascimento P; Cosendey R; Ferrari A; Lopes VS; Hospital Universitario Antonio Pedro, UFF, Niteroi, RJ, Brazil.; OBJECTIVE: To evaluate the cardiac abnormalities and their evolution during the course of the acquired immunodeficiency syndrome, as well as to correlate clinical and pathological data. METHODS: Twenty-one patients, admitted to the hospital with the diagnosis of acquired immunodeficiency syndrome, were prospectively s
Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7.: Biochem J. 2000 Mar 15;346 Pt 3:587-91. Unique Identifier : AIDSLINE MED/20164040; Ciruela A; Hinchliffe KA; Divecha N; Irvine RF; Department of Pharmacology, University of Cambridge, Tennis Court; Road, Cambridge CB2 1QJ, U.K.; Type II phosphatidylinositol phosphate kinases (PIPkins) have recently been found to be primarily phosphatidylinositol 5-phosphate 4-kinases, and their physiological role remains unclear. We have previously shown that a Type II PIPkin [isoform(s) unknown], is localized partly in the nucleus [Divecha, Rhee, Letcher and
A salt bridge between an N-terminal coiled coil of gp41 and an antiviral agent targeted to the gp41 core is important for anti-HIV-1 activity.: Biochem Biophys Res Commun. 2000 Apr 2;270(1):153-7. Unique Identifier : AIDSLINE MED/20200110; Jiang S; Debnath AK; Lindsley F. Kimball Research Institute, New York Blood Center,; 310 East 67th Street, New York, New York 10021, USA.; sjiang@nybc.org; HIV-1 envelope glycoprotein transmembrane subunit gp41 play a critical role in the fusion of viral and target cell membranes. The gp41 C-terminal heptad repeat region interacts with the N-terminal coiled-coil region to form a six-stranded core structure. Peptides derived from gp41 C-terminal heptad repeat region (C-pe
Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein.: Biochem Biophys Res Commun. 2000 Apr 2;270(1):23-7. Unique Identifier : AIDSLINE MED/20200089; Seo T; Lee D; Lee B; Chung JH; Choe J; Department of Biological Sciences, Korea Advanced Institute of; Science and Technology, Taejon, 305-701, Korea.; Kaposi s sarcoma-associated herpesvirus (KSHV) contains many cellular homologue genes. The K9 open reading frame (ORF) of KSHV encodes a virus-encoded interferon regulatory factor (vIRF) which functions as a repressor for cellular interferon-mediated signal transduction, and as an oncogene to induce cell growth transf
Engineering of a mini-trichosanthin that has lower antigenicity by deleting its C-terminal amino acid residues.: Biochem Bi