Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Unique Identifier : AIDSLINE MED/99371968
Menozzi G; Mosti L; Bruno O; Lo Presti E; Musiu C; Longu S; La Colla P; Filippelli W; Falcone G; Piucci B; Dipartimento di Scienze Farmaceutiche, Universita di Genova,; Italy. menozzi@unige.it
Abstract: A series of pyrazole analogues of bifonazole, an antifungal drug used in clinical practice, 2a-h and 4a-h were synthesized and tested in vitro against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, with no significant results. Imidazoles 2a-h were also tested in vivo for antiarrhythmic and antihypertensive activities; two of these compounds showed moderate activity against ventricular fibrillation caused by aconitine in rats. The above compounds were prepared by reaction of phenyl-[5 substituted 1-phenyl (or 1-methyl)-1H-pyrazol-4-yl]methanols with N,N'-carbonyldiimidazole (2a-h) or of the respective chloro derivatives with 1H-1,2,4-triazole (4a-h).
000130
A0011323
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