Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Farmaco. 1999 Sep 30;54(9):624-8. Unique Identifier : AIDSLINE MED/20022964
Pandeya SN; Sriram D; Nath G; De Clercq E; Department of Pharmaceutics, Banaras Hindu University, Varanasi,; India. snpande@banaras.ernet.in
Abstract: Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4"-methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of the compounds was made by the agar dilution method against 28 pathogenic bacteria, eight pathogenic fungi and anti-HIV activity against replication of HIV-1 (III B) in MT-4 cells. The compounds are significantly active against bacteria and fungi.
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A0011322
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