Plasmid expressing the influenza HA gene protects old mice from lethal challenge with influenza virus. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Plasmid expressing the influenza HA gene protects old mice from lethal challenge with influenza virus.

Viral Immunol. 1999;12(3):217-26. Unique Identifier : AIDSLINE MED/20000450
Radu DL; Antohi S; Bot A; Weksler ME; Bona C; Department of Microbiology, Mount Sinai School of Medicine, New; York, New York 10029, USA.

Abstract: Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with plasmids expressing the HA gene induced comparable clearance of influenza virus from the lungs and the same level of protection from a lethal challenge with live WSN influenza virus. Thus, genetic immunization may offer advantages for the elderly over virus-base vaccines.

Keywords: JOURNAL ARTICLE Aging/*IMMUNOLOGY Animal Antibodies, Viral/IMMUNOLOGY Cells, Cultured Chick Embryo Disease Models, Animal Female Gene Expression Hemagglutinin Glycoproteins, Influenza Virus/GENETICS/*IMMUNOLOGY Human Influenza/IMMUNOLOGY/PREVENTION & CONTROL Influenza A Virus, Human/GENETICS/*IMMUNOLOGY Interferon Type II/BIOSYNTHESIS Interleukin-4/BIOSYNTHESIS Lung/IMMUNOLOGY/VIROLOGY Mice Mice, Inbred BALB C *Plasmids Support, U.S. Gov't, P.H.S. T-Lymphocytes, Cytotoxic/IMMUNOLOGY Th1 Cells/IMMUNOLOGY/VIROLOGY Th2 Cells/IMMUNOLOGY/VIROLOGY Vaccination Vaccines, DNA/*IMMUNOLOGY Viral Vaccines/*IMMUNOLOGY

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