Evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 Epstein-Barr virus. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 Epstein-Barr virus.

J Virol. 1999 Nov;73(11):9206-12. Unique Identifier : AIDSLINE GENBANK/AF183140
Cho YG; Gordadze AV; Ling PD; Wang F; Department of Medicine, Brigham & Women's Hospital, Harvard; Medical School, Boston, Massachusetts 02115, USA.

Abstract: Rhesus monkeys and other nonhuman Old World primates are naturally infected with lymphocryptoviruses (LCV) that are closely related to Epstein-Barr virus (EBV). A rhesus LCV isolate (208-95) was derived from a B-cell lymphoma in a simian immunodeficiency virus-infected rhesus macaque. The EBNA-2 homologues from 208-95 and a previous rhesus LCV isolate (LCL8664) were polymorphic on immunoblotting, so the EBNA-2 genes from these two rhesus LCV were cloned, sequenced, and compared. The EBNA-2 genes have 40% nucleotide and 41% amino acid identities, and the differences are similar to those between the type 1 and type 2 EBV EBNA-2. Sequence from a portion of the LMP1 gene which is extremely divergent among different LCV was virtually identical between the 208-95 and LCL8664 strains, confirming a common rhesus LCV background. Thus, the EBNA-2 polymorphism defines the presence of two different rhesus LCV types, and both rhesus LCV types were found to be prevalent in the rhesus monkey population at the New England Regional Primate Research Center. The existence of two rhesus LCV types suggests that the selective pressure for the evolution of two LCV types is shared by human and nonhuman primate hosts.

Keywords: JOURNAL ARTICLE Amino Acid Sequence Animal Base Sequence Cell Line Cloning, Molecular Epstein-Barr Virus Nuclear Antigens/CHEMISTRY/GENETICS *Evolution, Molecular Herpesviridae Infections/VETERINARY/VIROLOGY Human Immunoblotting Lymphocryptovirus/*CLASSIFICATION/*GENETICS/ISOLATION & PURIF Lymphoma, B-Cell/VETERINARY/VIROLOGY Macaca mulatta Molecular Sequence Data Monkey Diseases/VIROLOGY Papio Polymorphism (Genetics) Sequence Analysis, DNA Simian Acquired Immunodeficiency Syndrome/COMPLICATIONS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Tumor Virus Infections/VETERINARY/VIROLOGY Viral Matrix Proteins/CHEMISTRY/GENETICS

KWDjournalarticleaminoacidsequenceanimalbasesequencecelllinecloning,molecularepstein-barrvirusnuclearantigens/chemistry/geneticsKWDevolution,molecularherpesviridaeinfections/veterinary/virologyhumanimmunoblottinglymphocryptovirus/KWDclassification/
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