2000
- Peripheral lymphocyte subsets and other immune aspects in Rett syndrome.
- Pediatr Neurol. 1999 Sep;21(3):619-21. Unique Identifier : AIDSLINE MED/99441845
- Fiumara A; Sciotto A; Barone R; D'Asero G; Munda S; Parano E; Pavone L; Department of Paediatric Neurology, Paediatric Clinic, University; of Catania, Italy.
- A possible role of the immune system in the pathogenesis of some neurologic disorders, including infantile autism, was recently postulated. This observation prompted the authors to investigate some immunologic aspects in a group of patients with Rett syndrome, a disorder still not completely clarified but with some po
- Synthesis and biological evaluation of [alpha-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole.
- Unique Identifier : AIDSLINE MED/99371968
- Menozzi G; Mosti L; Bruno O; Lo Presti E; Musiu C; Longu S; La Colla P; Filippelli W; Falcone G; Piucci B; Dipartimento di Scienze Farmaceutiche, Universita di Genova,; Italy. menozzi@unige.it
- A series of pyrazole analogues of bifonazole, an antifungal drug used in clinical practice, 2a-h and 4a-h were synthesized and tested in vitro against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, with no significant results. Imidazoles 2a-h were also tested in vivo for antiarrhythmic and antihy
- Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine.
- Farmaco. 1999 Sep 30;54(9):624-8. Unique Identifier : AIDSLINE MED/20022964
- Pandeya SN; Sriram D; Nath G; De Clercq E; Department of Pharmaceutics, Banaras Hindu University, Varanasi,; India. snpande@banaras.ernet.in
- Isatin and its derivatives have been reacted with 4-(4 -chlorophenyl)-6-(4 -methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of the compounds was mad
- Regression and spreading of self-recognition during the development of autoimmune demyelinating disease.
- J Autoimmun. 1999 Aug;13(1):11-20. Unique Identifier : AIDSLINE MED/99371720
- Tuohy VK; Yu M; Yin L; Kawczak JA; Kinkel PR; Department of Immunology, Lerner Research Institute, The; Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.; tuohv@ccf.org
- The autoimmune T cell repertoire in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) is characterized by CD4(+)T cells of the Th1 phenotype that recognize peptide determinants of central nervous system (CNS) myelin proteins in an MHC class II-restricted manner. Our recent studies and those p
- Human retrovirus-5 in rheumatic disease.
- J Autoimmun. 1999 Aug;13(1):149-54. Unique Identifier : AIDSLINE MED/99371737
- Brand A; Griffiths DJ; Herve C; Mallon E; Venables PJ; Chelsea and Westminster Hospital, London, UK.
- It has long been suggested that retroviral infection may play a role in the pathogenesis of autoimmune rheumatic disease. Particles resembling retroviruses have been reported in tissue from patients with Sjogren s syndrome, lupus and rheumatoid arthritis, and molecular mimicry between retroviral antigens and host prot
- Th1 predominance and perforin expression in minor salivary glands from patients with primary Sjogren's syndrome.
- J Autoimmun. 1999 Aug;13(1):155-62. Unique Identifier : AIDSLINE MED/99371738
- Kolkowski EC; Reth P; Pelusa F; Bosch J; Pujol-Borrell R; Coll J; Jaraquemada D; Immunology Unit, Facultat de Medicina, Universitat Autonoma de; Barcelona, Barcelona, Spain.
- Objectives of this study were to examine the cytokine and perforin mRNA expression in minor salivary glands from patients with primary Sjogren s syndrome (pSS), searching for possible correlation with clinical parameters and to identify the dominant cytokine pattern in the different groups. Oral mucosa biopsy samples
- Th2 T cells expressing transgene PDGF-A serve as vectors for gene therapy in autoimmune demyelinating disease.
- J Autoimmun. 1999 Aug;13(1):31-8. Unique Identifier : AIDSLINE MED/99371722
- Mathisen PM; Yu M; Yin L; Johnson JM; Kawczak JA; Nishiyama A; Tuohy VK; Department of Immunology, Lerner Research Institute, The; Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH,; 44195, USA.
- We hypothesized that T cells can be genetically modified to express growth factor transgene products capable of inducing oligodendrocyte progenitor proliferation. Autoreactive T cells isolated from SWXJ mice immunized with the p139-151 determinant of myelin proteolipid protein (PLP) were transfected with an antigen-in
- Plasma lactoferrin levels are decreased in end-stage AIDS patients.
- Viral Immunol. 1999;12(3):197-203. Unique Identifier : AIDSLINE MED/20000448
- van der Strate BW; Harmsen MC; The TH; Sprenger HG; de Vries H; Eikelboom MC; Kuipers ME; Meijer DK; Swart PJ; Department of Pharmacokinetics and Drug Delivery, Groningen; University Institute for Drug Exploration, University Centre for; Pharmacy, The Netherlands. B.W.A.van.der.Strate@farm.rug.nl
- The antimicrobial protein lactoferrin (Lf) is present in plasma and in mucosal secretions. Using ELISA we analysed plasma and saliva of HIV-infected patients, patients with AIDS, and healthy controls for the presence of secreted Lf. The plasma Lf levels of AIDS patients (classification C3) were significantly lower (p
- Immunogenicity of full length and truncated SIV envelope proteins.
- Viral Immunol. 1999;12(3):205-15. Unique Identifier : AIDSLINE MED/20000449
- Vzorov AN; Lea-Fox D; Compans RW; Department of Microbiology and Immunology, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.
- We have compared the immunogenicity of the full-length (FL) SIV envelope (Env) protein and a truncated (T) form of the Env protein which has a short cytoplasmic tail. The Env(T) protein was previously shown to be more fusogenic than Env(FL), has a higher level of incorporation into virus-like particles (VLPs) and memb
- Plasmid expressing the influenza HA gene protects old mice from lethal challenge with influenza virus.
- Viral Immunol. 1999;12(3):217-26. Unique Identifier : AIDSLINE MED/20000450
- Radu DL; Antohi S; Bot A; Weksler ME; Bona C; Department of Microbiology, Mount Sinai School of Medicine, New; York, New York 10029, USA.
- Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with pla
- Accommodation.
- Immunol Today. 1999 Oct;20(10):434-7. Unique Identifier : AIDSLINE MED/99431571
- Soares MP; Lin Y; Sato K; Stuhlmeier KM; Bach FH; Immunobiology Research Center, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, MA 02215, USA.; msoares@caregroup.harvard.edu
- Measurement of T-cell kinetics: recent methodologic advances.
- Immunol Today. 1999 Oct;20(10):438-41. Unique Identifier : AIDSLINE MED/99431572
- Hellerstein MK; Dept of Nutritional Sciences, 309 Morgan Hall, University of; California at Berkeley, CA 94720-3104, USA.; march@nature.berkeley.edu
- The moving target: mechanisms of HIV persistence during primary infection.
- Immunol Today. 1999 Oct;20(10):446-50. Unique Identifier : AIDSLINE MED/99431574
- Soudeyns H; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Dept of Internal Medicine,; Centre Hospitalier Universitaire Vaudois, Lausanne 1011,; Switzerland.
- The vigorous host immune responses detected during primary HIV infection fail to prevent the establishment of chronic infection because HIV has evolved multiple strategies to make these responses ineffective. Here, Hugo Soudeyns and Giuseppe Pantaleo discuss the mechanisms that allow HIV to persist in the host.
- Positive selection of thymocytes: the long and winding road.
- Immunol Today. 1999 Oct;20(10):463-8. Unique Identifier : AIDSLINE MED/99431577
- Anderson G; Hare KJ; Jenkinson EJ; Dept of Anatomy, MRC Centre for Immune Regulation, Division of; Infection and Immunity, The Medical School, University of; Birmingham, Edgbaston, Birmingham, UK B15 2TT.; andersog@novell2.bham.ac.uk
- Positive selection is a crucial stage in T-cell development because it is here that CD4+CD8+ cells bearing T-cell receptors that interact with self-major histocompatibility complex molecules are rescued from cell death, resulting in the generation of mature T cells. Here, Graham Anderson and colleagues review recent s
- Is there a balance between microglia and astrocytes in regulating Th1/Th2-cell responses and neuropathologies?
- Immunol Today. 1999 Nov;20(11):477-9. Unique Identifier : AIDSLINE MED/20001982
- Xiao BG; Link H; Division of Neurology, Karolinska Institute, Huddinge University; Hospital, S-141 86 Huddinge, Stockholm, Sweden.; bao-guo.xiao@neurotec.ki.se
- Can eradication of helminthic infections change the face of AIDS and tuberculosis?
- Immunol Today. 1999 Nov;20(11):485-7. Unique Identifier : AIDSLINE MED/20001984
- Bentwich Z; Kalinkovich A; Weisman Z; Borkow G; Beyers N; Beyers AD; R. Ben-Ari Institute of Clinical Immunology, AIDS Center, Kaplan; Medical Center, Hebrew University Hadassah Medical School,; Rehovot, Israel. bentwich@agri.huji.ac.il
- Eotaxin: from an eosinophilic chemokine to a major regulator of allergic reactions.
- Immunol Today. 1999 Nov;20(11):500-4. Unique Identifier : AIDSLINE MED/20001987
- Gutierrez-Ramos JC; Lloyd C; Gonzalo JA; Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA; 02139, USA. gutierrez@mpi.com
- Th2-deviation of fetus-specific T cells [letter]
- Immunol Today. 1999 Nov;20(11):534. Unique Identifier : AIDSLINE MED/20001993
- Ekerfelt C; Matthiesen L; Berg G; Ernerudh J
- Imaging features of Pneumocystis carinii pneumonia.
- Crit Rev Diagn Imaging. 1999 Aug;40(4):251-84. Unique Identifier : AIDSLINE MED/99444526
- Crans CA Jr; Boiselle PM; Department of Diagnostic Imaging, Temple University Hospital,; Philadelphia, PA.
- Despite a declining prevalence secondary to improved prophylaxis, Pneumocystis carinii remains an important pulmonary pathogen in the immunocompromised host. Because the radiologist is often the first to suggest the diagnosis of PCP, an awareness of the entire spectrum of imaging features associated with this organism
- Chemokines and the human immunodeficiency virus.
- Chem Immunol. 1999;72:121-40. Unique Identifier : AIDSLINE MED/20018597
- Poli G; AIDS Immunophathogenesis Unit, DiBiT, San Raffaele Scientific; Institute, Milano, Italy. poli.guido@hsr.it
- Inhibition of the expression and function of chemokine receptors on human CD4+ leukocytes by HIV-1 envelope protein gp120.
- Chem Immunol. 1999;72:141-60. Unique Identifier : AIDSLINE MED/20018598
- Su SB; Ueda H; Howard OM; Grimm MC; Gong W; Ruscetti FW; Oppenheim JJ; Wang JM; Laboratory of Molecular Immunoregulation, SAIC, Frederick,; National Cancer Institute, Md., USA.
- Strategies to interfere with the chemokine network in disease.
- Chem Immunol. 1999;72:181-201. Unique Identifier : AIDSLINE MED/20018600
- Wells TN; Proudfoot AE; Power CA; Serono Pharmaceutical Research Institute, Geneva, Switzerland.; Tim.wells@serono.com
- CCR2: from cloning to the creation of knockout mice.
- Chem Immunol. 1999;72:30-41. Unique Identifier : AIDSLINE MED/20018591
- Charo IF; Gladstone Institute of Cardiovascular Disease, San Francisco,; Calif., USA. icharo@gladstone.ucsf.edu
- The role of CD26/DPP IV in chemokine processing.
- Chem Immunol. 1999;72:42-56. Unique Identifier : AIDSLINE MED/20018592
- Van Damme J; Struyf S; Wuyts A; Van Coillie E; Menten P; Schols D; Sozzani S; De Meester I; Proost P; Laboratory of Molecular Immunology, University of Leuven,; Belgium. jozef.vandamme@rega.kuleuven.ac.be
- DNA priming-protein boosting enhances both antigen-specific antibody and Th1-type cellular immune responses in a murine herpes simplex virus-2 gD vaccine model.
- DNA Cell Biol. 1999 Oct;18(10):771-9. Unique Identifier : AIDSLINE MED/20007449
- Sin JI; Bagarazzi M; Pachuk C; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.
- It has previously been reported that herpes simplex virus (HSV)-2 gD DNA vaccine preferentially induces T-helper (Th) 1-type cellular immune responses, whereas the literature supports the view that subunit vaccines tend to induce potent antibody responses, supporting a Th2 bias. Here, using an HSV gD vaccine model, we
- What is the role of regulatory T cells in transplantation tolerance?
- Curr Opin Immunol. 1999 Oct;11(5):497-503. Unique Identifier : AIDSLINE MED/99439585
- Zhai Y; Kupiec-Weglinski JW; The Dumont-UCLA Transplant Center, University of California (Los; Angeles) School of Medicine, Department of Surgery, Room 77-120,; Center for Health Science, 10833 Le Conte Avenue, Los Angeles, CA; 90095, USA.
- There has been considerable recent progress in the characterization of the regulatory T cells that mediate tolerance in a number of transplantation models. The conditions that facilitate the generation of regulatory T cells point to the thymus, the nature of immune suppression and the dose of immunosuppressive agent(s
- Hydroxyurea and HIV: 5 years later--from antiviral to immune-modulating effects [editorial]
- AIDS. 1999 Aug 20;13(12):1433-42. Unique Identifier : AIDSLINE MED/99392734
- Lori F
- A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro.
- AIDS. 1999 Aug 20;13(12):1443-52. Unique Identifier : AIDSLINE MED/99392735
- Brana C; Biggs TE; Barton CH; Sundstrom LE; Mann DA; Department of Clinical Neurological Sciences, University of; Southampton, Southampton General Hospital, UK.
- OBJECTIVES: There is now a strong consensus that the neurotoxic properties of HIV-1 are likely to be mediated by an indirect mechanism in which neurones are damaged by infected mononuclear cells. The aim of this study was to determine the ability of HIV-1 Tat to induce neurotoxic properties in a murine macrophage cell
- The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.
- AIDS. 1999 Aug 20;13(12):1453-9. Unique Identifier : AIDSLINE MED/99392736
- Napolitano G; Licciardo P; Gallo P; Majello B; Giordano A; Lania L; Department of Genetics, University of Naples Federico II, and; International Institute of Genetics and Biophysics, Italy.
- OBJECTIVES: To examine the functional interaction between HIV-1 Tat protein and the cyclin T1 and T2 proteins which, in association with cyclin dependent kinase (CDK)9, are the regulatory subunits of the TAK/P-TEFb cellular complex strictly required for Tat transactivation. DESIGN: HIV-1 long terminal repeat (LTR) rep
- Recombinant gp160 as a therapeutic vaccine for HIV-infection: results of a large randomized, controlled trial. European Multinational IMMUNO AIDS Vaccine Study Group.
- AIDS. 1999 Aug 20;13(12):1461-8. Unique Identifier : AIDSLINE MED/99392737
- Goebel FD; Mannhalter JW; Belshe RB; Eibl MM; Grob PJ; de Gruttola V; Griffiths PD; Erfle V; Kunschak M; Engl W; Medizinische Poliklinik, University of Munich, Germany.
- OBJECTIVES: The primary objective of this study was to expand the safety and immunogenicity database of recombinant gp160 as a therapeutic vaccine in the treatment of HIV-infection. Preliminary efficacy data was also sought. DESIGN: This trial was a randomized, double-blind, placebo-controlled study. Two-hundred and e
- Human polyomavirus JC latency and reactivation status in blood of HIV-1-positive immunocompromised patients with and without progressive multifocal leukoencephalopathy.
- AIDS. 1999 Aug 20;13(12):1469-75. Unique Identifier : AIDSLINE MED/99392738
- Andreoletti L; Dubois V; Lescieux A; Dewilde A; Bocket L; Fleury HJ; Wattre P; Laboratoire de Virologie, Lille, France.
- BACKGROUND: Human polyomavirus JC (JCV) induces human progressive multifocal leukoencephalopathy (PML) in patients with AIDS. Peripheral blood mononuclear cells (PBMC) of HIV-1-positive immunocompetent and immunocompromised patients can harbour JCV genome, but their precise role in JCV latency or reactivation status b
- Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV.
- AIDS. 1999 Aug 20;13(12):1477-83. Unique Identifier : AIDSLINE MED/99392739
- Witvrouw M; Pannecouque C; Van Laethem K; Desmyter J; De Clercq E; Vandamme AM; Rega Institute for Medical Research, Leuven, Belgium.
- BACKGROUND: After the initial discovery of 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT) and tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and thione (TIBO) derivatives, several other non-nucleoside reverse transcriptase (RT) inhibitors (NNRTI), including
- Salvage therapy with regimens containing ritonavir and saquinavir in extensively pretreated HIV-infected patients.
- AIDS. 1999 Aug 20;13(12):1485-9. Unique Identifier : AIDSLINE MED/99392740
- Fatkenheuer G; Hoetelmans RM; Hunn N; Schwenk A; Franzen C; Reiser M; Jutte A; Rockstroh J; Diehl V; Salzberger B; Department of Internal Medicine, University of Koln, Germany.
- OBJECTIVE: To evaluate the efficacy and toxicity of salvage regimens containing ritonavir and saquinavir in patients failing highly active antiretroviral therapy (HAART), and to correlate outcome with plasma concentrations of
- Cerebrospinal fluid HIV-1 RNA levels in asymptomatic patients with early stage chronic HIV-1 infection: support for the hypothesis of local virus replication.
- AIDS. 1999 Aug 20;13(12):1491-6. Unique Identifier : AIDSLINE MED/99392741
- Garcia F; Niebla G; Romeu J; Vidal C; Plana M; Ortega M; Ruiz L; Gallart T; Clotet B; Miro JM; Pumarola T; Gatell JM; Infectious Diseases Unit, Institut d'Investigacions Biomediques,; August Pi I Sunyer Hospital Clinic, Faculty of Medicine,; University of Barcelona, Spain.
- OBJECTIVE: To assess HIV-1 RNA levels in cerebrospinal fluid (CSF) and their potential correlation with plasma viral load and central nervous system (CNS) HIV-1 infection markers in stable asymptomatic patients with a CD4 T cell count >500x10(6) cells/l. PATIENTS AND METHODS: Consecutive patients screened for two tria
- Incidence and risk factors for developing cytomegalovirus retinitis in HIV-infected patients receiving protease inhibitor therapy. Spanish CMV-AIDS Study Group.
- AIDS. 1999 Aug 20;13(12):1497-502. Unique Identifier : AIDSLINE MED/99392742
- Casado JL; Arrizabalaga J; Montes M; Marti-Belda P; Tural C; Pinilla J; Gutierrez C; Portu J; Schuurman R; Aguirrebengoa K; Infectious Diseases Unit, Hospital Ramon y Cajal, Madrid, Spain.
- OBJECTIVE: To assess the incidence and risk factors for cytomegalovirus ( CMV ) retinitis in HIV-infected patients who initiated protease inhibitor-containing antiretroviral therapy. DESIGN AND SETTING: Prospective, multicentre
- Sampling lymphoid tissue cells by ultrasound-guided fine needle aspiration of lymph nodes in HIV-infected patients. Swiss HIV Cohort Study.
- AIDS. 1999 Aug 20;13(12):1503-9. Unique Identifier : AIDSLINE MED/99392743
- Bart PA; Meuwly JY; Corpataux JM; Yerly S; Rizzardi P; Fleury S; Munoz M; Knabenhans C; Welbon C; Pantaleo G; Meylan PR; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, University of Lausanne, Switzerland.
- OBJECTIVE: To establish the feasibility of using ultrasound-guided lymph node needle aspiration as a means to obtain lymphoid tissue cells for the determination of a series of immunologic and virologic measures in HIV-infected patients. DESIGN: First, a comparison of the characteristics of cell populations obtained by
- Phase 1 trial of nonoxynol-9 film among sex workers in South Africa.
- AIDS. 1999 Aug 20;13(12):1511-5. Unique Identifier : AIDSLINE MED/99392744
- Rustomjee R; Abdool Karim Q; Abdool Karim SS; Laga M; Stein Z; Centre for Epidemiological Research in South Africa, South; African Medical Research Council, Durban.
- OBJECTIVES: To assess the acceptability and safety of a vaginal nonoxynol-9 film in a group of sex workers at a truck stop in South Africa . DESIGN: A randomized double-blinded crossover trial was conducted between April 1995 and July 1995. INTERVENTION: Seventy-two mg nonoxynol-9
- Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child HIV-1 transmission in Durban, South Africa. South African Vitamin A Study Group.
- AIDS. 1999 Aug 20;13(12):1517-24. Unique Identifier : AIDSLINE MED/99392745
- Coutsoudis A; Pillay K; Spooner E; Kuhn L; Coovadia HM; Department of Paediatrics and Child Health, University of Natal,; Africa Centre for Population Studies and Reproductive Health,; South Africa.
- OBJECTIVE: Poor vitamin A status has been associated with a higher risk for mother-to-child transmission of HIV-1 and there is contradictory evidence on the impact of vitamin A on perinatal outcome. We therefore assessed the effect of vitamin A supplementation to mothers on birth outcome and mother-to-child transmissi
- Gay men report high rates of unprotected anal sex with partners of unknown or discordant HIV status.
- AIDS. 1999 Aug 20;13(12):1525-33. Unique Identifier : AIDSLINE MED/99392746
- Ekstrand ML; Stall RD; Paul JP; Osmond DH; Coates TJ; Center for AIDS Prevention Studies, University of California, San; Francisco, USA.
- OBJECTIVE: To examine patterns and factors that correlate with unprotected anal intercourse (UAI) practices among San Francisco gay men, including UAI with partners of unknown or different HIV antibody status. DESIGN: A longitudinal cohort recruited for the San Francisco Young Men s Health Study in 1992; re-assessed a
- Mortality in young adults in England and Wales: the impact of the HIV epidemic.
- AIDS. 1999 Aug 20;13(12):1535-41. Unique Identifier : AIDSLINE MED/99392747
- Nylen G; Mortimer J; Evans B; Gill N; PHLS AIDS and STD Centre, Communicable Diseases Surveillance; Centre, London, UK.
- OBJECTIVE: To quantify the contribution of the HIV epidemic to premature mortality in England and Wales 1985-1996. DESIGN: Surveillance of deaths in HIV-infected individuals and causes of death from death certificates. MAIN OUTCOME MEASURES: Time trends in age-specific mortality rates among 15-44 year olds and years o
- Relapse and mortality among HIV-infected and uninfected patients with tuberculosis successfully treated with twice weekly directly observed therapy in rural South Africa.
- AIDS. 1999 Aug 20;13(12):1543-7. Unique Identifier : AIDSLINE MED/99392748
- Connolly C; Reid A; Davies G; Sturm W; McAdam KP; Wilkinson D; Centre for Epidemiological Research in South Africa, Medical; Research Council, Durban.
- OBJECTIVE: To determine post-treatment relapse and mortality rates among HIV-infected and uninfected patients with tuberculosis treated with a twice-weekly drug regimen under direct observation (DOT). SETTING: Hlabisa, South Africa . PATIENTS: A group of 403 patients with tuberculo
- Tuberculosis preventive therapy for HIV-infected people in sub-Saharan Africa is cost-effective [see comments]
- AIDS. 1999 Aug 20;13(12):1549-56. Unique Identifier : AIDSLINE MED/99392749
- Bell JC; Rose DN; Sacks HS; Thomas C. Chalmers Clinical Trials Unit, Mount Sinai School of; Medicine, New York, New York 10029, USA.
- OBJECTIVE: Since antiretroviral therapy is largely unavailable to HIV-infected patients in developing countries and recent clinical trials have shown that tuberculosis (TB) preventive therapy can reduce TB and HIV-associated morbidity and mortality, we studied the effectiveness and cost-effectiveness of TB preventive
- A psychological epidemiology of people seeking HIV/AIDS counselling in Kenya: an approach for improving counsellor training [see comments]
- AIDS. 1999 Aug 20;13(12):1557-67. Unique Identifier : AIDSLINE MED/99392750
- Vollmer NA; Valadez JJ; Plan International, Arlington, VA 22201, USA.
- OBJECTIVE: This study develops a typology of psychological problems reported during HIV/AIDS counselling. This typology provides a framework for training paraprofessional counsellors (PPCs) in East Africa. DESIGN: Study participants included 307 Kenyans tested for HIV at any of six clinics in Nairobi specialising in S
- Costs and benefits to the mother of antenatal HIV testing: estimates from simulation modelling.
- AIDS. 1999 Aug 20;13(12):1569-76. Unique Identifier : AIDSLINE MED/99392751
- Gibb DM; Ades AE; Gupta R; Sculpher MJ; MRC Clinical Trials Unit, University College London Medical; School, UK.
- OBJECTIVE: To assess the health service costs and benefits for the woman of an earlier HIV diagnosis as a result of antenatal HIV testing. DESIGN: A model of maternal disease progression was developed based on the rate of decline in CD4 cell counts and applied to two matched simulated cohorts of women with identical i
- HIV counseling in sub-Saharan Africa [editorial; comment]
- AIDS. 1999 Aug 20;13(12):1577-9. Unique Identifier : AIDSLINE MED/99392752
- Kaaya SF; Fawzi MC
- Tuberculosis preventive therapy in people living with HIV in sub-Saharan Africa [editorial; comment]
- AIDS. 1999 Aug 20;13(12):1581-2. Unique Identifier : AIDSLINE MED/99392753
- Godfrey-Faussett P
- HLA-unrestricted killing of HIV-1 gag protein-expressing CD4 T cells by gag-specific CD8 cytotoxic T cells [letter; comment]
- AIDS. 1999 Aug 20;13(12):1583-4. Unique Identifier : AIDSLINE MED/99392754
- Salerno-Goncalves R; Lu W; Achour A; Andrieu JM
- Characterization of a third CCR5 amplicon from CCR5-delta32-heterozygous HIV-1-infected individuals [letter]
- AIDS. 1999 Aug 20;13(12):1585-6. Unique Identifier : AIDSLINE MED/99392755
- Aikhionbare FO; Newman C; Womack C; Roth WW; Stringer HG Jr; Bond VC
- Reversible zidovudine-induced pure red cell aplasia [letter]
- AIDS. 1999 Aug 20;13(12):1586-7. Unique Identifier : AIDSLINE MED/99392756
- Blanche P; Silberman B; Barreto L; Gombert B; Sicard D
- Quality of life in asymptomatic patients with early HIV infection initiating antiretroviral therapy. Swiss HIV Cohort Study [letter]
- AIDS. 1999 Aug 20;13(12):1587-9. Unique Identifier : AIDSLINE MED/99392757
- Zinkernagel C; Ledergerber B; Battegay M; Cone RW; Vernazza P; Hirschel B; Opravil M
- Treatment of painful distal sensory polyneuropathy in HIV-infected patients with a topical agent: results of an open-label trial of 5% lidocaine gel [letter]
- AIDS. 1999 Aug 20;13(12):1589-90. Unique Identifier : AIDSLINE MED/99392758
- Dorfman D; Dalton A; Khan A; Markarian Y; Scarano A; Cansino M; Wulff E; Simpson D
- Serum thrombopoietin levels correlate with disease progression of AIDS [letter]
- AIDS. 1999 Aug 20;13(12):1590-1. Unique Identifier : AIDSLINE MED/99392759
- Gatanaga H; Hoshikawa N; Tahara T; Kato T; Oka S
- Salvage therapy in HIV-positive patients with a previous therapeutic experience with protease inhibitors. Members of the Master Group [letter]
- AIDS. 1999 Aug 20;13(12):1591-2. Unique Identifier : AIDSLINE MED/99392760
- Maggiolo F; Maserati R; Pan A; Castelli F; Suter F
- Hydroxyurea-induced neurotoxicity in HIV disease [letter]
- AIDS. 1999 Aug 20;13(12):1592-4. Unique Identifier : AIDSLINE MED/99392761
- Barry M; Clarke S; Mulcahy F; Back D
- Changes in plasma HIV-RNA and CD4 lymphocyte counts in patients receiving highly active antiretroviral therapy [letter]
- AIDS. 1999 Aug 20;13(12):1594-5. Unique Identifier : AIDSLINE MED/99392762
- Maggiolo F; Bottura P; Capra R; Pirali A; Zaffaroni P; Suter F
- The frequency of anonymous HIV testing in the United States: data from a national survey [letter]
- AIDS. 1999 Aug 20;13(12):1595-7. Unique Identifier : AIDSLINE MED/99392763
- Anderson JE
- Sentinel surveillance for HIV infection and risk behavior among adolescents entering juvenile detention in San Francisco: 1990-1995 [letter]
- AIDS. 1999 Aug 20;13(12):1597-8. Unique Identifier : AIDSLINE MED/99392764
- Kim AA; McFarland W; Kellogg T; Katz MH
- Adjustment of antenatal clinic HIV surveillance data for HIV-associated differences in fertility [letter; comment]
- AIDS. 1999 Aug 20;13(12):1598-9. Unique Identifier : AIDSLINE MED/99392765
- Glynn JR; Buve A; Carael M; Zaba B
- Sexual behavioural study of commercial sex workers and their clients in Cambodia. Japan-Cambodia Collaborating Research Group [letter]
- AIDS. 1999 Aug 20;13(12):1599-601. Unique Identifier : AIDSLINE MED/99392766
- Morio S; Soda K; Tajima K; Leng HB
- Changes in viral load during acute respiratory infections in HIV-infected patients [letter]
- AIDS. 1999 Aug 20;13(12):1601-2. Unique Identifier : AIDSLINE MED/99392767
- Villar-Arias A; Pinilla-Moraza J; Labarga-Echeverria P; Anton-Botella F
- The interaction of opportunistic infections and HIV replication [editorial]
- AIDS. 1999 Sep 10;13(13):1603-6. Unique Identifier : AIDSLINE MED/99437258
- Powderly WG
- Cell-associated HIV-1 messenger RNA and DNA in T-helper cell and monocytes in asymptomatic HIV-1-infected subjects on HAART plus an inactivated HIV-1 immunogen.
- AIDS. 1999 Sep 10;13(13):1607-11. Unique Identifier : AIDSLINE MED/99437259
- Patterson BK; Carlo DJ; Kaplan MH; Marecki M; Pawha S; Moss RB; Northwestern University Medical School, Department of; Obstetrics/Gynecology and Medicine, Chicago, Illinois 60611, USA.; bpatters@nmh.org
- OBJECTIVE: We examined the effect of an HIV-1-specific immune-based therapy on cell-associated HIV-1 DNA and RNA. DESIGN: Five HIV-1-infected subjects receiving HIV-1 immunogen plus HAART were compared with three HIV-1-infected subjects who received incomplete Freund s adjuvant (IFA) plus HAART. METHODS: Cell-associat
- Emerging recombinant human immunodeficiency viruses: uneven representation of the envelope V3 region.
- AIDS. 1999 Sep 10;13(13):1613-21. Unique Identifier : AIDSLINE MED/99437260
- Renjifo B; Gilbert P; Chaplin B; Vannberg F; Mwakagile D; Msamanga G; Hunter D; Fawzi W; Essex M; Harvard AIDS Institute, Boston, Massachusetts 02115-6017, USA.
- OBJECTIVE: To determine whether the envelope V3 region from HIV-1 subtypes A, C or D had the same probability of being present in intersubtype recombinant genomes. MATERIALS AND METHODS: The envelope C2-C5 and the gag p24-p7 regions from one hundred infants infected perinatally in Ta
- Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors.
- AIDS. 1999 Sep 10;13(13):1623-7. Unique Identifier : AIDSLINE MED/99437261
- Profit L; Eagling VA; Back DJ; Department of Pharmacology and Therapeutics, University of; Liverpool, UK.
- OBJECTIVES: To determine the effect of the protease inhibitors ritonavir , nelfinavir and indinavir on the P-glycoprotein (P-gp)-me
- Peripheral blood mononuclear cell markers in antiretroviral therapy-naive HIV-infected and high risk seronegative adolescents. Adolescent Medicine HIV/AIDS Research Network.
- AIDS. 1999 Sep 10;13(13):1629-35. Unique Identifier : AIDSLINE MED/99437262
- Douglas SD; Rudy B; Muenz L; Moscicki AB; Wilson CM; Holland C; Crowley-Nowick P; Vermund SH; Children's Hospital of Philadelphia, Department of Pediatrics of; the University of Pennsylvania School of Medicine, 19104-4399,; USA.
- OBJECTIVE: To examine potential hematologic and immunologic markers for healthy adolescents and for adolescents infected with HIV. DESIGN: The REACH Project (Reaching for Excellence in Adolescent Care and Health) of the Adolescent Medicine HIV/AIDS Research Network (AMHARN) recruits HIV-infected and high-risk HIV-unin
- Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells.
- AIDS. 1999 Sep 10;13(13):1637-45. Unique Identifier : AIDSLINE MED/99437263
- Mischiati C; Pironi F; Milani D; Giacca M; Mirandola P; Capitani S; Zauli G; Department of Morphology and Embryology, University of Ferrara,; Italy.
- OBJECTIVE: To investigate the intracellular signals elicited by extracellular HIV-1 Tat protein in lymphoid CD4 T cells. METHODS: CD4 Jurkat T cells were treated with a series of glutathione S-transferase (GST)-Tat fusion proteins: full-length two-exon GST-Tat (GST-Tat2E); one-exon Tat, in which the second exon of Tat
- Can chemoprophylaxis against opportunistic infections be discontinued after an increase in CD4 cells induced by highly active antiretroviral therapy?
- AIDS. 1999 Sep 10;13(13):1647-51. Unique Identifier : AIDSLINE MED/99437264
- Kirk O; Lundgren JD; Pedersen C; Nielsen H; Gerstoft J; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Hvidovre, Denmark.
- BACKGROUND: In the USPHS/IDSA Guidelines for Prevention of Opportunistic Infections in Persons Infected with Human Immunodeficiency Virus , the indications for chemoprophylaxis are based on nadir CD4 cell count. Many patients have, however, experienced an increase in CD4 cell count after the introduction of highly ac
- Preliminary experiences with triple therapy including nelfinavir and two reverse transcriptase inhibitors in previously untreated HIV-infected children.
- AIDS. 1999 Sep 10;13(13):1653-8. Unique Identifier : AIDSLINE MED/99437265
- Funk MB; Linde R; Wintergerst U; Notheis G; Hoffmann F; Schuster T; Kornhuber B; Ahrens P; Kreuz W; Children's Hospital, Johann Wolfgang Goethe-University Frankfurt,; Germany.
- OBJECTIVE: In an intent-to-treat study increase in CD4 cell count, reduction of viral load, clinical benefit and adverse reactions were examined in HIV-infected previously treatment-naive children taking triple therapy. METHODS: sixteen HIV-infected children in category A or B on antiretroviral triple therapy were fol
- A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy.
- AIDS. 1999 Sep 10;13(13):1659-67. Unique Identifier : AIDSLINE MED/99437266
- Saint-Marc T; Partisani M; Poizot-Martin I; Bruno F; Rouviere O; Lang JM; Gastaut JA; Touraine JL; Transplantation and Clinical Immunology Unit, Pavillon P,; Hopital Edouard-Herriot, Lyon, France.
- OBJECTIVE: To compare body composition, body fat distribution and insulin secretion in patients taking nucleoside reverse transcriptase inhibitor (NRTI) therapy. DESIGN AND SETTING: Cross-sectional study in three French AIDS clinical centres. PATIENTS: Forty-three HIV-infected patients on long-term NRTI therapy includ
- CD4 cell counts at the third month of HAART may predict clinical failure.
- AIDS. 1999 Sep 10;13(13):1669-76. Unique Identifier : AIDSLINE MED/99437267
- d'Arminio Monforte A; Testori V; Adorni F; Castelnuovo B; Bini T; Testa L; Moscatelli G; Chiesa E; Rusconi S; Abeli C; Sollima S; Musicco M; Meroni L; Galli M; Moroni M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy.
- OBJECTIVE: To evaluate the influence of immunological and virological markers on clinical outcome in patients receiving their first highly active antiretroviral therapy (HAART) regimen. DESIGN AND METHODS: Observational study of 585 patients initiating HAART in a clinical setting. Clinical failure was defined as the o
- Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS Clinical Trial Group and Neurological AIDS Research Consortium study team.
- AIDS. 1999 Sep 10;13(13):1677-85. Unique Identifier : AIDSLINE MED/99437268
- Price RW; Yiannoutsos CT; Clifford DB; Zaborski L; Tselis A; Sidtis JJ; Cohen B; Hall CD; Erice A; Henry K; University of California, San Francisco, USA.
- OBJECTIVE: In a large multi-center clinical trial of combination reverse transcriptase inhibitors (RTIs), we assessed the impact of antiretroviral therapy on neurological function, the relationship between neurological and systemic benefit, and the prognostic value of neurological performance in late HIV-1 infection.
- Effects of antiretroviral therapy and opportunistic illness primary chemoprophylaxis on survival after AIDS diagnosis. Adult/Adolescent Spectrum of Disease Group.
- Unique Identifier : AIDSLINE MED/99437269
- McNaghten AD; Hanson DL; Jones JL; Dworkin MS; Ward JW; Council of State and Territorial Epidemiologists, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.
- OBJECTIVE: To examine the effects of antiretroviral therapy (ART) and opportunistic illness chemoprophylaxis on the survival of persons with AIDS and survival time based on year of AIDS diagnosis. DESIGN: Longitudinal medical record review. SETTING: Ninety-three hospitals and clinics in nine cities in the USA. PATIENT
- Photofrin photodynamic therapy for treatment of AIDS-related cutaneous Kaposi's sarcoma.
- AIDS. 1999 Sep 10;13(13):1697-704. Unique Identifier : AIDSLINE MED/99437270
- Bernstein ZP; Wilson BD; Oseroff AR; Jones CM; Dozier SE; Brooks JS; Cheney R; Foulke L; Mang TS; Bellnier DA; Dougherty TJ; Department of Medicine, Roswell Park Cancer Institute, Buffalo,; New York 14263, USA.
- OBJECTIVE: Kaposi s sarcoma, the most common malignancy in AIDS patients, often presents with painful cutaneous lesions that are difficult to treat effectively despite a wide variety of therapeutic approaches. We used photodynamic therapy in an attempt to provide effective palliative treatment for this disease. METHOD
- Emergence of zidovudine and multidrug-resistance mutations in the HIV-1 reverse transcriptase gene in therapy-naive patients receiving stavudine plus didanosine combination therapy. STADI Group.
- AIDS. 1999 Sep 10;13(13):1705-9. Unique Identifier : AIDSLINE MED/99437271
- Pellegrin I; Izopet J; Reynes J; Denayrolles M; Montes B; Pellegrin JL; Massip P; Puel J; Fleury H; Segondy M; Department of Virology, Bordeaux University Hospital, France.
- OBJECTIVE: Assessment of genotypic changes in the reverse transcriptase gene of HIV-1 occurring in antiretroviral naive patients treated by stavudine plus didanosine combination therapy . METHODS: Sequence analysis (codons 1-230) was performed after amplification of the
- Methadone maintenance treatment modalities in relation to incidence of HIV: results of the Amsterdam cohort study.
- AIDS. 1999 Sep 10;13(13):1711-6. Unique Identifier : AIDSLINE MED/99437272
- Langendam MW; van Brussel GH; Coutinho RA; van Ameijden EJ; Division of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands. mlangendam@gggd.amsterdam.nl
- STUDY OBJECTIVE: To evaluate methadone maintenance treatment modalities, prescribed within the concept of harm reduction, in relation to incidence of HIV infection among drug users with a history of methadone treatment in Amsterdam, The Netherlands . DESIGN: Prospective observa
- The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1-infected women: results of the women's interagency HIV study.
- AIDS. 1999 Sep 10;13(13):1717-26. Unique Identifier : AIDSLINE MED/99437273
- Anastos K; Kalish LA; Hessol N; Weiser B; Melnick S; Burns D; Delapenha R; DeHovitz J; Cohen M; Meyer W; Bremer J; Kovacs A; Montefiore Medical Center, Bronx, New York, USA.
- OBJECTIVES: To determine factors associated with survival and to assess the relative strength of CD4 cell count and HIV-1 RNA in predicting survival in a cohort of HIV-1-infected women. DESIGN: Prospective cohort, enrolled during 1994-1995, with median follow-up of 29 months RESULTS: Of 1769 HIV-infected women 252 die
- A randomized study comparing instruments for measuring health-related quality of life in HIV-infected patients. Spanish MOS-HIV and MQOL-HIV Validation Group. Medical Outcomes Study HIV Health Survey.
- Unique Identifier : AIDSLINE MED/99437274
- Badia X; Podzamczer D; Garcia M; Lopez-Lavid C C; Consiglio E; Catalan Institute of Public Health, University of Barcelona,; L'Hospitalet de Llobregat, Spain. xbadia@bell.ub.es
- OBJECTIVE: To compare the feasibility, reliability, validity and sensitivity to change of the MOS-HIV and MQOL-HIV in order to determine their suitability for use in clinical research. METHODS: Five hundred and fifty-eight HIV-infected patients and 80 healthy blood donors were randomly assigned to receive the MOS-HIV
- Nosocomial HIV-transmission in an outpatient clinic detected by epidemiological and phylogenetic analyses [see comments]
- AIDS. 1999 Sep 10;13(13):1737-44. Unique Identifier : AIDSLINE MED/99437275
- Katzenstein TL; Jorgensen LB; Permin H; Hansen J; Nielsen C; Machuca R; Gerstoft J; Department of Infectious Diseases, Rigshopitalet, Copenhagen,; Denmark. Terese@RH.DK
- OBJECTIVE: To determine if a case of HIV-infection in a patient (GP) with common variable immunodeficiency, and with no known risk factors for HIV-infection, could be due to horizontal nosocomial transmission. METHODS: For determination of time of transmission stored serum-samples from GP were analysed for HIV RNA con
- Cost-effectiveness of counseling and testing and partner notification: a decision analysis.
- AIDS. 1999 Sep 10;13(13):1745-51. Unique Identifier : AIDSLINE MED/99437276
- Varghese B; Peterman TA; Holtgrave DR; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.
- OBJECTIVE: Counseling and testing and partner notification are effective HIV prevention strategies, but they can be resource intensive. This paper evaluates the cost-effectiveness of partner notification and counseling and testing offered in HIV and sexually transmitted disease (STD) clinics in preventing future HIV i
- Mobilizing young gay and bisexual men for HIV prevention: a two-community study.
- AIDS. 1999 Sep 10;13(13):1753-62. Unique Identifier : AIDSLINE MED/99437277
- Kegeles SM; Hays RB; Pollack LM; Coates TJ; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.
- BACKGROUND: To develop, implement and evaluate a community-level HIV prevention program (the Mpowerment Project) for young gay men in two US communities. DESIGN: Using a multiple baseline design, a cohort of young gay men was recruited independently of the intervention in each community and surveyed twice (1 year apar
- Sociodemographic and psychological variables influencing adherence to antiretroviral therapy.
- AIDS. 1999 Sep 10;13(13):1763-9. Unique Identifier : AIDSLINE MED/99437278
- Gordillo V; del Amo J; Soriano V; Gonzalez-Lahoz J; Department of Research Methodology in Education, University; Complutense, Hospital Carlos III, Madrid, Spain.; gordillo@eucmax.sim.ucm.es
- OBJECTIVE: To assess the degree of compliance with antiretroviral therapy in HIV-infected patients, and identify which sociodemographic and psychological factors influence it, in order to develop strategies to improve adherence. DESIGN AND SETTING: Cross-sectional study in a reference HIV/AIDS institution located in M
- Adherence communication: a qualitative analysis of physician-patient dialogue.
- AIDS. 1999 Sep 10;13(13):1771-8. Unique Identifier : AIDSLINE MED/99437279
- Roberts KJ; Volberding P; Department of Sociology, University of California, Los Angeles; 90095-1551, USA.
- OBJECTIVE: To explore how HIV/AIDS care physicians communicate with HIV-positive patients about the need for adherence to antiretroviral treatment regimens. DESIGN: Semi-structured, face-to-face interviews, a qualitative research method. SETTING: A comprehensive, multidisciplinary, HIV/AIDS practice at San Francisco G
- Away with multi-use vials! [editorial; comment]
- AIDS. 1999 Sep 10;13(13):1779-81. Unique Identifier : AIDSLINE MED/99437280
- Mortimer PP
- HIV infection among pregnant women in the South African private medical sector [letter]
- AIDS. 1999 Sep 10;13(13):1783. Unique Identifier : AIDSLINE MED/99437281
- Wilkinson D
- Reliability of tuberculin purified derivative skin testing and delayed-type hypersensitivity skin test anergy in HIV-infected homosexual men, at risk of tuberculosis [letter]
- AIDS. 1999 Sep 10;13(13):1784-5. Unique Identifier : AIDSLINE MED/99437282
- Maas JJ; Foudraine NA; Schellekens PT; Mensen ME; Veenstra J; Roos MT; van Leeuwen R; Coutinho RA
- Mucus impaction presenting as a lung mass in an AIDS patient with asthma [letter]
- AIDS. 1999 Sep 10;13(13):1785-7. Unique Identifier : AIDSLINE MED/99437283
- Mc Ilraith TB; Noskin GA; Corbridge TC
- Hypersensitivity reactions to high-dose co-trimoxazole in HIV-infected Malaysian and Scottish patients [letter]
- AIDS. 1999 Sep 10;13(13):1787-8. Unique Identifier : AIDSLINE MED/99437284
- Pakianathan MR; Kamarulzaman A; Ismail R; McMillan A; Scott GR
- Ritonavir and warfarin interaction [letter]
- AIDS. 1999 Sep 10;13(13):1788-9. Unique Identifier : AIDSLINE MED/99437285
- Newshan G; Tsang P
- Impact of opportunistic diseases on survival in HIV-infected patients in France, 1992-1997. Clinical Epidemiology Group from Centres d'Information et de Soins de l'Immunodeficience Humaine [letter]
- AIDS. 1999 Sep 10;13(13):1789-90. Unique Identifier : AIDSLINE MED/99437286
- Lievre L; Meyohas MC; Costagliola D
- Exacerbation of skin mycobacterial lesions under highly active antiretroviral therapy in an HIV-infected patient [letter]
- AIDS. 1999 Sep 10;13(13):1790-1. Unique Identifier : AIDSLINE MED/99437287
- Sotto A; Guillot B; Dandurand M; Jourdan J
- A syndrome resembling primary aldosteronism (Conn syndrome) in untreated HIV disease [letter]
- AIDS. 1999 Sep 10;13(13):1791-2. Unique Identifier : AIDSLINE MED/99437288
- Stricker RB; Goldberg DA; Hu C; Hsu JW; Goldberg B
- Recurrence of cytomegalovirus retinitis in an HIV-infected patient responsive to highly active antiretroviral therapy late after discontinuation of gancyclovir [letter]
- AIDS. 1999 Sep 10;13(13):1792-4. Unique Identifier : AIDSLINE MED/99437289
- Bertelli D; Stellini R; Cadeo GP
- Ritonavir-saquinavir rescue therapy in HIV-positive patients failing with indinavir, rotinavir or saquinavir [letter]
- AIDS. 1999 Sep 10;13(13):1794-5. Unique Identifier : AIDSLINE MED/99437290
- De Wit S; Cassano P; Hermans P; Sommereijns B; Kabeya K; O'Doherty E; Clumeck N
- Increasing morbidity from myocardial infarction during HIV protease inhibitor treatment? [letter]
- AIDS. 1999 Sep 10;13(13):1796-7. Unique Identifier : AIDSLINE MED/99437291
- Jutte A; Schwenk A; Franzen C; Romer K; Diet F; Diehl V; Fatkenheuer G; Salzberger B
- Multiple myeloma in two HIV-infected patients [letter]
- AIDS. 1999 Sep 10;13(13):1797-9. Unique Identifier : AIDSLINE MED/99437292
- Faure I; Viallard JF; Mercie P; Bonnefoy M; Pellegrin JL; Leng B
- The gp120 envelope of HIV-1 binds and presents peptides in a similar manner to human leukocyte antigen [letter]
- AIDS. 1999 Sep 10;13(13):1799-801. Unique Identifier : AIDSLINE MED/99437293
- Sheikh J; Souberbielle B; Westby M; Austen B; Dalgleish AG
- HIV-1 disease progression in women: role of the viral phenotype of the HIV-positive steady partner [letter]
- AIDS. 1999 Sep 10;13(13):1801-2. Unique Identifier : AIDSLINE MED/99437294
- Fiore JR; Buccoliero G; Pezzotti P; Rezza G; Saracino A; Pastore G; Fenyo EM; Angarano G
- Ritonavir-induced Cushing's syndrome in a patient treated with nasal fluticasone [letter]
- AIDS. 1999 Sep 10;13(13):1803. Unique Identifier : AIDSLINE MED/99437295
- Hillebrand-Haverkort ME; Prummel MF; ten Veen JH
- Detection of Epstein-Barr virus and human herpesvirus-8 DNA from Kaposi's sarcoma in patients with AIDS [letter]
- AIDS. 1999 Sep 10;13(13):1804-6. Unique Identifier : AIDSLINE MED/99437296
- Mastroianni A; Sabbatini AM; Portolani M; Cancellieri C
- Interaction of sildenafil and indinavir when co-administered to HIV-positive patients.
- AIDS. 1999 Oct 22;13(15):F101-7. Unique Identifier : AIDSLINE MED/20012342
- Merry C; Barry MG; Ryan M; Tjia JF; Hennessy M; Eagling VA; Mulcahy F; Back DJ; Department of Pharmacology and Therapeutics, Trinity Centre of; Health Sciences, St James's Hospital, Dublin, Ireland.
- OBJECTIVES: The prevalence of erectile dysfunction in HIV-infected men is estimated to be 33%. Sildenafil citrate (Viagra; Pfizer Ltd, Sandwich, Kent, UK) is the first oral drug for this condition. Since sildenafil and the p
- HIV-specific immunity following immunization with HIV synthetic envelope peptides in asymptomatic HIV-infected patients.
- AIDS. 1999 Oct 22;13(15):2003-12. Unique Identifier : AIDSLINE MED/20012343
- Pinto LA; Berzofsky JA; Fowke KR; Little RF; Merced-Galindez F; Humphrey R; Ahlers J; Dunlop N; Cohen RB; Steinberg SM; Nara P; Shearer GM; Yarchoan R; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
- OBJECTIVE: A phase I trial was conducted to evaluate the safety and immunogenicity of an HIV synthetic peptide vaccine in HIV-seropositive individuals. The immunogens used in this study were PCLUS 3-18MN and PCLUS 6.1-18MN envelope peptides. METHODS: Eight HIV-infected patients received six subcutaneous injections of
- HIV-1 exposed dendritic cells show increased pro-inflammatory cytokine production but reduced IL-1ra following lipopolysaccharide stimulation.
- Unique Identifier : AIDSLINE MED/20012344 P P
- Lore K; Sonnerborg A; Olsson J; Patterson BK; Fehniger TE
- Expression and utilization of co-receptors in HIV and simian immunodeficiency virus infection of megakaryocytes.
- Unique Identifier : AIDSLINE MED/20012345
- Park IW; Wang JF; Groopman JE
- OBJECTIVE: To analyse the expression and specificity of co-receptors for the entry of HIV and simian immunodeficiency virus (SIV) into megakaryocytes. DESIGN AND METHODS: The expression of co-receptors was determined by flow cytometric analysis in combination with reverse transcription-polymerase chain (RT-PCR) reacti
- Enhanced HIV infectivity and changes in GP120 conformation associated with viral incorporation of human leucocyte antigen class I molecules.
- AIDS. 1999 Oct 22;13(15):2033-42. Unique Identifier : AIDSLINE MED/20012346
- Cosma A; Blanc D; Braun J; Quillent C; Barassi C; Moog C; Klasen S; Spire B; Scarlatti G; Pesenti E; Siccardi AG; Beretta A; Centre Integre de Recherches Biocliniques sur le SIDA, Paris,; France.
- BACKGROUND: Assembly of human immunodeficiency virus type 1 (HIV-1) occurs at the level of the plasma membrane of the host cell. During this process HIV incorporates significant quantities of cell surface-derived molecules into its lipid bilayer including human leucocyte antigen (HLA) class I and II, intercellular adh
- Functional and genetic integrity of the CD8 T-cell repertoire in advanced HIV infection.
- AIDS. 1999 Oct 22;13(15):2043-53. Unique Identifier : AIDSLINE MED/20012347
- Gamberg JC; Bowmer MI; Trahey JC; Campbell CM; Pardoe I; Grant MD; Immunology Program, Faculty of Medicine, Memorial University of; Newfoundland, St. John's, Canada.
- BACKGROUND: HIV-specific cytotoxic T lymphocytes (CTL) can restrict HIV replication in acute and chronic infection, but disease progression occurs in parallel with declining CTL activity. An understanding of why CTL fail to control HIV replication might reveal important mechanisms of disease progression and enhance pr
- HIV mediates a productive infection of the brain.
- Unique Identifier : AIDSLINE MED/20012348
- Wiley CA; Achim CL; Christopherson C; Kidane Y; Kwok S; Masliah E; Mellors J; Radhakrishnan L; Wang G; Soontornniyomkij V
- BACKGROUND: Approximately one quarter of patients with AIDS develop severe cognitive deficits called HIV-associated dementia complex. There is some controversy regarding the importance of viral load and distribution in mediating this neurologic disease. OBJECTIVE: Brain HIV provira
- Analysis of HIV cross-resistance to protease inhibitors using a rapid single-cycle recombinant virus assay for patients failing on combination therapies.
- AIDS. 1999 Oct 22;13(15):2061-8. Unique Identifier : AIDSLINE MED/20012349
- Race E; Dam E; Obry V; Paulous S; Clavel F; Laboratoire de Recherche Antivirale, Hopital Bichat-Claude; Bernard, Paris, France.
- OBJECTIVE: To assess the patterns of HIV phenotypic cross-resistance to protease inhibitors (PI) in patients experiencing viral load rebound on combination therapy including a PI. METHODS: Phenotypic analysis of sens
- Effectiveness of isoniazid chemoprophylaxis for HIV-infected drug users at high risk for active tuberculosis.
- AIDS. 1999 Oct 22;13(15):2069-74. Unique Identifier : AIDSLINE MED/20012350
- Gourevitch MN; Hartel D; Selwyn PA; Schoenbaum EE; Klein RS; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Albert Einstein College of Medicine, Bronx, New; York 10467, USA. mgourevi@montefiore.org
- OBJECTIVE: To define the effectiveness of chemoprophylaxis, outside of a clinical trial setting, in preventing tuberculosis among tuberculin-reactive and anergic HIV-infected drug users at high risk of developing active tuberculosis. DESIGN: An observational cohort study. SETTING: Methadone maintenance treatment progr
- Use of observational databases to evaluate the effectiveness of antiretroviral therapy for HIV infection: comparison of cohort studies with randomized trials. EuroSIDA, the French Hospital Database on HIV and the Swiss HIV Cohort Study Groups.
- AIDS. 1999 Oct 22;13(15):2075-82. Unique Identifier : AIDSLINE MED/20012351
- Phillips AN; Grabar S; Tassie JM; Costagliola D; Lundgren JD; Egger M; Royal Free Centre for HIV Medicine and Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, University College London, UK.
- OBJECTIVES: It is important to assess the extent of bias when comparing the clinical efficacy of antiretroviral regimens in observational databases because, with the current lack of planned large trials, such analyses may represent the only means of assessing the risk of serious clinical events associated with new reg
- The relationship between ritonavir plasma levels and side-effects: implications for therapeutic drug monitoring.
- AIDS. 1999 Oct 22;13(15):2083-9. Unique Identifier : AIDSLINE MED/20012352
- Gatti G; Di Biagio A; Casazza R; De Pascalis C; Bassetti M; Cruciani M; Vella S; Bassetti D; Department of Infectious Diseases, University of Genoa, Italy.; gigatti@smartino.ge.it
- OBJECTIVES: To assess whether the neurological or gastrointestinal adverse effects of ritonavir correlate with parameters of ritonavir systemic exposure. METHODS: Peak (Cmax) and trough (Cmin) ritonavir plasma levels were compared in 11 patients experiencing side-effects (group A) versus 10 patients without side-effec
- Effect of intrauterine device use on cervical shedding of HIV-1 DNA.
- AIDS. 1999 Oct 22;13(15):2091-7. Unique Identifier : AIDSLINE MED/20012353
- Richardson BA; Morrison CS; Sekadde-Kigondu C; Sinei SK; Overbaugh J; Panteleeff DD; Weiner DH; Kreiss JK; Department of Biostatistics, University of Washington, Seattle; 98195, USA.
- OBJECTIVE: Hormonal contraception has been associated with an increased prevalence of cervical shedding of HIV-1 DNA among infected women. We conducted this study to evaluate the effect of the use of an intrauterine device (IUD) on the detection of HIV-1 DNA in cervical secretions. DESIGN: A prospective study of HIV-1
- Recombinant human growth hormone improves the fat redistribution syndrome (lipodystrophy) in patients with HIV.
- AIDS. 1999 Oct 22;13(15):2099-103. Unique Identifier : AIDSLINE MED/20012354
- Wanke C; Gerrior J; Kantaros J; Coakley E; Albrecht M; Division of Infectious Disease, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, MA, USA.; cwanke@infonet.tufts.edu
- OBJECTIVE: To determine the efficacy of recombinant human growth hormone (rhGH) in the treatment of the fat redistribution syndrome (FRS) in patients with HIV. DESIGN: A prospective, open-label study. SETTING: An urban, university-affiliated Infectious Disease Clinic. PATIENTS: Ten HIV-infected patients (seven men, th
- Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma.
- AIDS. 1999 Oct 22;13(15):2105-11. Unique Identifier : AIDSLINE MED/20012355
- Bower M; Fox P; Fife K; Gill J; Nelson M; Gazzard B; Department of Oncology, Chelsea and Westminster Hospital, London,; UK. m.bower@cxwms.ac.uk
- OBJECTIVE: To evaluate the impact of highly active antiretroviral therapy (HAART) on Kaposi s sarcoma. DESIGN: Retrospective study of patients who had received systemic or local treatment for AIDS-related Kaposi s sarcoma who subsequently commenced HAART. METHODS: Case note review to determine time to treatment failur
- Relative risks and population attributable fraction of incident HIV associated with symptoms of sexually transmitted diseases and treatable symptomatic sexually transmitted diseases in Rakai District, Uganda. Rakai Project Team.
- AIDS. 1999 Oct 22;13(15):2113-23. Unique Identifier : AIDSLINE MED/20012356
- Gray RH; Wawer MJ; Sewankambo NK; Serwadda D; Li C; Moulton LH; Lutalo T; Wabwire-Mangen F; Meehan MP; Ahmed S; Paxton LA; Kiwanuka N; Nalugoda F; Korenromp EL; Quinn TC; Department of Population and Family Health Sciences, School of; Hygiene and Public Health, Johns Hopkins University, Baltimore,; Maryland 21205, USA.
- OBJECTIVES: To assess the linkage of sexually transmitted disease (STD) symptoms and treatable STD to HIV incidence. DESIGN: Analysis of a randomized trial of STD control for HIV prevention, Rakai, Uganda . METHODS: Consenting adults 15-59 years of age were seen at 10-monthly home v
- Changes in survival among people with AIDS in Lazio, Italy from 1993 to 1998. Lazio AIDS Surveillance Collaborative Group [see comments]
- AIDS. 1999 Oct 22;13(15):2125-31. Unique Identifier : AIDSLINE MED/20012357
- Porta D; Rapiti E; Forastiere F; Pezzotti P; Perucci CA; Epidemiology Department Lazio Region, Rome, Italy.
- OBJECTIVES: To investigate temporal changes in survival of persons with AIDS (PWA) diagnosed in Lazio, Italy . DESIGN: Longitudinal study of 2862 PWA registered at the AIDS Surveillance System in the period 1 January 1993 to 30 June 1997 and followed for vital status up to 31 May 199
- Reduced fertility associated with HIV: the contribution of pre-existing subfertility.
- AIDS. 1999 Oct 22;13(15):2133-41. Unique Identifier : AIDSLINE MED/20012358
- Ross A; Morgan D; Lubega R; Carpenter LM; Mayanja B; Whitworth JA; Medical Research Council Programme on AIDS in Uganda, Uganda; Virus Research Institute, Entebbe.
- BACKGROUND: HIV-1 infection is associated with lower fertility among women in sub-Saharan Africa and this association is not explained by the frequency of sexual intercourse, illness, knowledge of HIV status or infection with other sexually transmitted diseases. Women with fertility problems are at increased risk of m
- Frequent detection of HIV-1 in the gastric aspirates of neonates born to HIV-infected mothers.
- AIDS. 1999 Oct 22;13(15):2143-9. Unique Identifier : AIDSLINE MED/20012359
- Mandelbrot L; Burgard M; Teglas JP; Benifla JL; Khan C; Blot P; Vilmer E; Matheron S; Firtion G; Blanche S; Mayaux MJ; Rouzioux C; Service de Gynecologie-Obstetrique I, Centre Hospitalier; Universitaire Cochin-Port Royal, Paris, France.
- OBJECTIVE: To evaluate the frequency and correlates of oral route exposure of infants born to HIV-1-infected women. METHODS: A multicenter study was performed within the prospective French Perinatal Cohort Study of mother-to-child HIV transmission. Oropharyngeal and gastric aspirates from 122 neonates were studied by
- Changes in HIV-related risk behaviors following drug abuse treatment.
- AIDS. 1999 Oct 22;13(15):2151-5. Unique Identifier : AIDSLINE MED/20012360
- Woods WJ; Guydish JR; Sorensen JL; Coutts A; Bostrom A; Acampora A; Department of Medicine, University of California San Francisco,; 94105, USA. bwoods@psg.ucsf.edu
- OBJECTIVES: To measure changes in HIV-related injection drug and sexual risk behaviors following drug treatment in a therapeutic community program. METHODS: We conducted a prospective cohort study of 261 drug users, randomly assigned to day or residential treatment. Participants were interviewed 2 weeks after entering
- Decreased morbidity and use of hospital services in English HIV-infected individuals with increased uptake of anti-retroviral therapy 1996-1997. National Prospective Monitoring System Steering Group.
- AIDS. 1999 Oct 22;13(15):2157-64. Unique Identifier : AIDSLINE MED/20012361
- Beck EJ; Mandalia S; Williams I; Power A; Newson R; Molesworth A; Barlow D; Easterbrook P; Fisher M; Innes J; Kinghorn G; Mandel B; Pozniak A; Tang A; Tomlinson D; NPMS Coordinating and Analytic Centre, Chelsea and Westminster; Hospital, London, UK. e.beck@ic.ac.uk
- OBJECTIVE: To investigate the relationship between changing morbidity patterns, the use of hospital services by HIV-infected patients and the uptake of antiretroviral therapy (ART) in England. DESIGN: Prospective serial cross-sectional analyses based on data collected through the National Prospective Monitoring System
- Assessing the impact of highly active antiretroviral therapy on AIDS and death [editorial; comment]
- AIDS. 1999 Oct 22;13(15):2165-6. Unique Identifier : AIDSLINE MED/20012362
- Sabin CA
- Report of gynecomastia in five male patients during antiretroviral therapy for HIV infection [letter]
- AIDS. 1999 Oct 22;13(15):2167-9. Unique Identifier : AIDSLINE MED/20012363
- Peyriere H; Mauboussin JM; Rouanet I; Merle C; Sotto A; Arnaud A; Hillaire-Buys D; Balmes P
- Seminal plasma RANTES levels positively correlate with seminal plasma HIV-1 RNA levels [letter]
- Unique Identifier : AIDSLINE MED/20012364
- Storey DF; Dolan MJ; Anderson SA; Meier PA; Walter EA
- Prolonged therapy with the fusion inhibitor T-20 in combination with oral antiretroviral agents in an HIV-infected individual [letter]
- AIDS. 1999 Oct 22;13(15):2171-3. Unique Identifier : AIDSLINE MED/20012365
- Pilcher CD; Eron JJ Jr; Ngo L; Dusek A; Sista P; Gleavy J; Brooks D; Venetta T; DiMassimo E; Hopkins S
- Nephropathy and renal colic in patients treated with indinavir, ritonavir plus indinavir or ritonavir plus saquinavir [letter]
- AIDS. 1999 Oct 22;13(15):2173-4. Unique Identifier : AIDSLINE MED/20012366
- Padberg J; Fritsche L; Bergmann F; Schurmann D; Suttorp N
- Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load [letter]
- AIDS. 1999 Oct 22;13(15):2174-6. Unique Identifier : AIDSLINE MED/20012367
- Patton LL; McKaig RG; Eron JJ Jr; Lawrence HP; Strauss RP
- Combination therapy with alpha interferon and lamivudine in patients with chronic hepatitis B and HIV infection [letter]
- AIDS. 1999 Oct 22;13(15):2176-8. Unique Identifier : AIDSLINE MED/20012368
- Nasti G; di Gennaro G; Donada C; Donadon V; Tirelli U
- Interleukin 1beta induces expression of human herpesvirus 8 encoded genes in BCBL-1 cells [letter]
- AIDS. 1999 Oct 22;13(15):2178-80. Unique Identifier : AIDSLINE MED/20012369
- Yu Y; Roan F; Offermann MK
- What dual protease inhibitor combination for salvage therapies? [letter]
- AIDS. 1999 Oct 22;13(15):2180-1. Unique Identifier : AIDSLINE MED/20012370
- Rodriguez-Rosado R; Soriano V; Barreiro P; Dona C; Gonzalez-Lahoz J
- Ingrown toenail and indinavir: case-control study demonstrates strong relationship [letter]
- AIDS. 1999 Oct 22;13(15):2181-2. Unique Identifier : AIDSLINE MED/20012371
- Bourezane Y; Thalamy B; Viel JF; Bardonnet K; Drobacheff C; Gil H; Vuitton DA; Hoen B
- Frequency of HIV false positivity from two sequential enzyme immunoassays in 111 639 sera [letter]
- AIDS. 1999 Oct 22;13(15):2182-3. Unique Identifier : AIDSLINE MED/20012372
- Chanbancherd P; Jugsudee A; Thanomklom S; Limpairojn N; Julananto P; Thienamporn P; Markowitz LE; de Souza MS; Brown AE
- Genetic diversity of HIV-1 subtype F from Brazil: failure of HIV-1 viral load testing based on molecular biology amplification methods [letter]
- AIDS. 1999 Oct 22;13(15):2183-5. Unique Identifier : AIDSLINE MED/20012373
- Mercado JM; Di Dio R; Pradal MG
- Localized Mycobacterium avium intracellulare psoas abscess in patients with AIDS after antiretroviral therapy [letter]
- AIDS. 1999 Oct 22;13(15):2185-6. Unique Identifier : AIDSLINE MED/20012374
- Boyd AE; Brettle RP
- Hydroxyurea reduces the 50% inhibitory concentration of didanosine in HIV-infected cells [letter]
- AIDS. 1999 Oct 22;13(15):2186-8. Unique Identifier : AIDSLINE MED/20012375
- Rana KZ; Simmons KA; Dudley MN
- The effects of discontinuing stavudine therapy on clinical and metabolic abnormalities in patients suffering from lipodystrophy [letter]
- AIDS. 1999 Oct 22;13(15):2188-9. Unique Identifier : AIDSLINE MED/20012376
- Saint-Marc T; Touraine JL
- Screening people living with HIV before tuberculosis preventative therapy [letter]
- AIDS. 1999 Oct 22;13(15):2190-1. Unique Identifier : AIDSLINE MED/20012377
- Godfrey-Faussett P; Quigley M; Ayles H; Mwinga A; Hosp M; Porter J
- The significance of bacteremic tuberculosis among persons with HIV infection in developing countries [editorial]
- AIDS. 1999 Nov 12;13(16):2193-5. Unique Identifier : AIDSLINE MED/20025228
- von Reyn CF
- HIV type 1 envelope glycoprotein gp120 induces development of a T helper type 2 response to Cryptococcus neoformans.
- AIDS. 1999 Nov 12;13(16):2197-207. Unique Identifier : AIDSLINE MED/20025229
- Pietrella D; Monari C; Retini C; Palazzetti B; Kozel TR; Vecchiarelli A; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.
- OBJECTIVE: To analyse the contribution of HIV type 1 envelope glycoprotein gp120 to regulation of a T-cell response to Cryptococcus neoformans. DESIGN: Monocytes treated with recombinant gp120 and exposed to C. neoformans were used as antigen presenting cells (APC) in coculture with autologous T lymphocytes. METHODS:
- A randomized trial comparing regimens of four reverse transcriptase inhibitors given together or cyclically in HIV-1 infection--the Quattro Trial. Quattro Steering Committee.
- AIDS. 1999 Nov 12;13(16):2209-17. Unique Identifier : AIDSLINE MED/20025230
- OBJECTIVES: To assess if cyclical therapy with four reverse transcriptase inhibitors is less toxic and as active, based on virological and immunological markers, as the same four drugs given together over a 64-week period. METHODS: An open randomized trial comparing concurrent therapy (T4) with zidovudine, lamivudine,
- Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patient.
- AIDS. 1999 Nov 12;13(16):2219-29. Unique Identifier : AIDSLINE MED/20025231
- Orenstein JM; Feinberg M; Yoder C; Schrager L; Mican JM; Schwartzentruber DJ; Davey RT Jr; Walker RE; Falloon J; Kovacs JA; Miller KD; Fox C; Metcalf JA; Masur H; Polis MA; Department of Pathology, George Washington University Medical; Center, Washington, DC 20037, USA. patjmo@gwumc.edu
- OBJECTIVES: To evaluate changes in architecture, viral RNA, and viral protein over 6 months in lymph nodes from retroviral-naive HIV-infected persons before and after commencing highly active antiretroviral therapy (HAART). METHODS: Nine antiretroviral-naive HIV-infected persons had lymph nodes excised at baseline and
- Sustained plasma TNF-alpha and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans.
- AIDS. 1999 Nov 12;13(16):2231-7. Unique Identifier : AIDSLINE MED/20025232
- Lawn SD; Shattock RJ; Acheampong JW; Lal RB; Folks TM; Griffin GE; Butera ST; HIV and Retrovirology Branch, Centers for Disease Control and; Prevention, Public Health Service, U.S. Department of Health and; Human Services, Atlanta, Georgia 30333, USA.
- OBJECTIVE: To determine the impact of treatment of tuberculosis on plasma HIV-1 load in African subjects and to correlate viral load with response to treatment and changes in immune activation. DESIGN: Clinical and microbiological responses, immune activation parameters and plasma HIV-1 load were determined in 20 pati
- The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1.
- AIDS. 1999 Nov 12;13(16):2239-50. Unique Identifier : AIDSLINE MED/20025233
- Moore KH; Barrett JE; Shaw S; Pakes GE; Churchus R; Kapoor A; Lloyd J; Barry MG; Back D; Glaxo Wellcome Research and Development, Greenford, UK.
- OBJECTIVE: To assess the pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells (PBMC) from patients infected with HIV-1. DESIGN: Single-center, open-label, randomized, two-period, cross-over study in 10 asymptomatic, antiretroviral-experienced, HIV-1-infected patients who had a CD4+ lymp
- Lipodystrophy defined by a clinical score in HIV-infected men on highly active antiretroviral therapy: correlation between dyslipidaemia and steroid hormone alterations.
- AIDS. 1999 Nov 12;13(16):2251-60. Unique Identifier : AIDSLINE MED/20025234
- Christeff N; Melchior JC; de Truchis P; Perronne C; Nunez EA; Gougeon ML; URA CNRS 1930, Departement SIDA et Retrovirus, Institut Pasteur,; Paris, France.
- BACKGROUND: A syndrome of lipodystrophy, associated with hypertriglyceridaemia, hypercholesterolaemia, hyperinsulinaemia and peripheral insulin resistance has been reported in protease inhibitor (PI)-treated HIV-infected patients. Because lipid metabolism, fat mass distribution and insulin resistance are partly regula
- Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy.
- AIDS. 1999 Nov 12;13(16):2261-7. Unique Identifier : AIDSLINE MED/20025235
- Domingo P; Matias-Guiu X; Pujol RM; Francia E; Lagarda E; Sambeat MA; Vazquez G; Department of Internal Medicine, Hospital de la Santa Creu i Sant; Pau, Universitat Autonoma de Barcelona, Spain.; pere.domingo@cc.uab.es
- BACKGROUND: Inhibitors of HIV-1 protease produce a rapid decrease in plasma HIV-1 RNA, with concomitant immune reconstitution. However, severe metabolic side effects together with a previously unseen form of lipodystrophy have been associated with long-term use of protease-inhibitor therapy. The pathogenic mechanisms
- The contribution of assay variation and biological variation to the total variability of plasma HIV-1 RNA measurements. The Women Infant Transmission Study Clinics. Virology Quality Assurance Program.
- AIDS. 1999 Nov 12;13(16):2269-79. Unique Identifier : AIDSLINE MED/20025236
- Brambilla D; Reichelderfer PS; Bremer JW; Shapiro DE; Hershow RC; Katzenstein DA; Hammer SM; Jackson B; Collier AC; Sperling RS; Fowler MG; Coombs RW; New England Research Institute, Watertown, MA 02472, USA.
- OBJECTIVES: To assess the specific contributions of assay variation and biological variation to the total variation of plasma HIV-1 RNA measured by the Roche Monitor assay and the extent to which batch assays reduced both assay variability and total variability compared with real-time determinations. DESIGN: A retrosp
- Regional survival differences across Europe in HIV-positive people: the EuroSIDA study.
- AIDS. 1999 Nov 12;13(16):2281-8. Unique Identifier : AIDSLINE MED/20025237
- Chiesi A; Mocroft A; Dally LG; Miller V; Katlama C; Ledergerber B; Pedersen C; Phillips AN; Arcieri R; Lundgren JD; Istituto Superiore di Sanita', Rome, Italy.
- OBJECTIVES: To analyse the survival differences between macro-regions of Europe (northern, central and southern Europe) between 1994 and early 1999, and their possible association with antiretroviral treatment differences. DESIGN: From September 1994 the EuroSIDA study has prospectively followed non-selected HIV-infec
- HIV treatments optimism and sexual behaviour among gay men in Sydney and Melbourne.
- Unique Identifier : AIDSLINE MED/20025238 P P
- Van de Ven P; Kippax S
- Risk perception and HIV-1 prevalence in 15,000 adults in rural south-west Uganda.
- AIDS. 1999 Nov 12;13(16):2295-302. Unique Identifier : AIDSLINE MED/20025239
- Kengeya-Kayondo JF; Carpenter LM; Kintu PM; Nabaitu J; Pool R; Whitworth JA; Medical Research Council (UK) Programme on AIDS in Uganda, Uganda; Virus Research Institute, Entebbe.
- OBJECTIVE: Few studies have described levels and determinants of perceived risk of HIV-1 among African adults for whom the sero-status is known. This study describes HIV risk perception obtained from a large rural population in south-west Uganda which also underwent serological tes
- Recent increases in HIV seroconversion among repeat anonymous testers in San Francisco [letter]
- AIDS. 1999 Nov 12;13(16):2303-4. Unique Identifier : AIDSLINE MED/20025240
- Kellogg T; McFarland W; Katz M
- Indication for increasing prevalence of resistance mutations for protease inhibitors in therapy-naive HIV-1-positive German patients [letter]
- AIDS. 1999 Nov 12;13(16):2304-5. Unique Identifier : AIDSLINE MED/20025241
- Dietrich U; Raudonat I; Wolf E; Jager H; Husak R; Orfanos CE; Knickmann M; Knechten H; von Briesen H; Ruppach H; Immelmann A
- Frozen shoulder in HIV patients treated with indinavir: report of three cases [letter]
- AIDS. 1999 Nov 12;13(16):2305-6. Unique Identifier : AIDSLINE MED/20025242
- Peyriere H; Mauboussin JM; Rouanet I; Rouveroux P; Hillaire-Buys D; Balmes P
- Prednisolone does not prevent the occurrence of nevirapine-induced rashes [letter]
- AIDS. 1999 Nov 12;13(16):2307. Unique Identifier : AIDSLINE MED/20025243
- Rey D; Partisani M; Krantz V; Kempf G; Nicolle M; de Mautort E; Priester M; Bernard-Henry C; Lang JM
- High circulating levels of soluble CD30 correlate with impaired delayed-type hypersensitivity responses in HIV-infected patients [letter]
- AIDS. 1999 Nov 12;13(16):2308-9. Unique Identifier : AIDSLINE MED/20025244
- Price P; Murray RJ; John M; French MA
- Severe anemia as a newly recognized side-effect caused by lamivudine [letter]
- AIDS. 1999 Nov 12;13(16):2309-11. Unique Identifier : AIDSLINE MED/20025245
- Weitzel T; Plettenberg A; Albrecht D; Lorenzen T; Stoehr A
- Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy [letter]
- AIDS. 1999 Nov 12;13(16):2311-2. Unique Identifier : AIDSLINE MED/20025246
- Kakuda TN; Brundage RC; Anderson PL; Fletcher CV
- Visceral obesity, hypertriglyceridemia and hypercortisolism in a boy with perinatally acquired HIV infection receiving protease inhibitor-containing antiviral treatment [letter]
- AIDS. 1999 Nov 12;13(16):2312-3. Unique Identifier : AIDSLINE MED/20025247
- Arpadi SM; Cuff PA; Horlick M; Kotler DP
- Family issues in HIV-infected haemophilic patients [letter]
- AIDS. 1999 Nov 12;13(16):2314-5. Unique Identifier : AIDSLINE MED/20025248
- Yee TT; Goldman E; Devereux H; Sabin C; Lee CA
- Silicones, hormones and HIV in transgender street prostitutes [letter]
- AIDS. 1999 Nov 12;13(16):2315-6. Unique Identifier : AIDSLINE MED/20025249
- Wiessing LG; van Roosmalen MS; Koedijk P; Bieleman B; Houweling H
- Advances in the medical management of patients with HIV-1 infection: an overview.
- AIDS. 1999 Sep;13 Suppl 1:S1-9. Unique Identifier : AIDSLINE MED/20012271
- Volberding PA; San Francisco General Hospital, UCSF AIDS Program, California; 94110, USA. pvolberding@PHP.UCSF.edu
- New guidelines for the management of patients with HIV-1 infection emphasize early aggressive treatment using multi-drug combination regimens. Accurate assessment of the effectiveness of these treatments and their potential (small as it now seems) to eradicate HIV-1 infection requires testing for viral levels in the b
- Viral kinetics: implications for treatment.
- AIDS. 1999 Sep;13 Suppl 1:S11-7. Unique Identifier : AIDSLINE MED/20012272
- Young B; Kuritzkes DR; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver, USA. denveridc@aol.com
- Increasing knowledge of the principles of viral dynamics in HIV infection has dramatically changed our understanding of the disease. Basic concepts of viral kinetics and implications for the treatment of HIV-infected persons are reviewed.
- HIV protease inhibitors: immunological insights.
- AIDS. 1999 Sep;13 Suppl 1:S19-27. Unique Identifier : AIDSLINE MED/20012273
- Mitsuyasu R; University of California at Los Angeles CARE Center, USA.
- Regimens of highly active antiretroviral therapy (HAART), including those containing one or more of the potent HIV protease inhibitors , often cause large increases in CD4 cell count as well as large decreases in plasma HIV RNA that persist over time. Patients improv
- HIV protease inhibitors: pharmacologic and metabolic distinctions.
- AIDS. 1999 Sep;13 Suppl 1:S29-40. Unique Identifier : AIDSLINE MED/20012274
- Sommadossi JP; Department of Clinical Pharmacology, Center for AIDS Research,; University of Alabama at Birmingham, School of Medicine,; 35294-0019, USA.
- In the earlier era of nucleoside analogue antiretroviral therapy, considerations of pharmacologic drug-drug interactions were only a small factor in choosing optimal therapies for patients with HIV infection. However, pharmacologic considerations are critical for selecting and managing the current multiple-drug antire
- Nelfinavir, a new protease inhibitor: early clinical results.
- AIDS. 1999 Sep;13 Suppl 1:S41-8. Unique Identifier : AIDSLINE MED/20012275
- Powderly WG; Tebas P; Division of Infectious Diseases, Washington University School of; Medicine, St Louis, Missouri 63110, USA.; wpowderl@imgate.wustl.edu
- Nelfinavir is a potent inhibitor of the HIV-1 protease, which shows good inhibitory activity against HIV-1 in vitro. Initial clinical trials have shown that it has excellent activity in vivo in HIV-infected patients. The combination of 750 mg nelfinavir three times daily with zidovudine and lamivudine has been shown t
- Antiretroviral therapy in 1999 for antiretroviral-naive individuals with HIV infection.
- AIDS. 1999 Sep;13 Suppl 1:S49-59. Unique Identifier : AIDSLINE MED/20012276
- Fischl MA; University of Miami School of Medicine, AIDS Clinical Research; Unit, Florida 33101, USA.
- The choice of initial antiretroviral regimen for treating people infected with HIV is crucial to successful long-term control of virus replication. Potent antiretroviral therapy substantially suppresses viral replication as measured by plasma HIV RNA levels to below limits of detection: the current standard of care is
- Attaining higher goals in HIV treatment: the central importance of adherence.
- AIDS. 1999 Sep;13 Suppl 1:S61-72. Unique Identifier : AIDSLINE MED/20012277
- Friedland GH; Williams A; AIDS Program, Yale University School of Medicine, New Haven,; Connecticut 06437, USA. gerald.Freidland!@yale.edu
- In recent years, advances in HIV therapeutics have changed the nature of HIV/AIDS disease, so that it has now assumed some of the characteristics of a chronic disease. Several factors have, however, qualified these advances. Social, economic, and clinical variables have confounded universal therapeutic success. Acce
- Quiz case 2. Coccidioidomycosis.
- Arch Otolaryngol Head Neck Surg. 1999 Oct;125(10):1159, 1161-2. Unique Identifier : AIDSLINE MED/99450347
- Spiegel JH; Sudilovsky D
- Allergic networks regulating eosinophilia [comment]
- Am J Respir Cell Mol Biol. 1999 Oct;21(4):451-4. Unique Identifier : AIDSLINE MED/99433893
- Foster PS; Division of Biochemistry and Molecular Biology, John Curtin; School of Medical Research, Australian National University,; Canberra, ACTON ACT, Australia. Paul.Foster@anu.edu.au
- Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines.
- Am J Respir Cell Mol Biol. 1999 Oct;21(4):528-36. Unique Identifier : AIDSLINE MED/99433902
- Pype JL; Dupont LJ; Menten P; Van Coillie E; Opdenakker G; Van Damme J; Chung KF; Demedts MG; Verleden GM; Laboratory of Pneumology, Laboratory of Molecular Immunology,; Rega Institute, Katholieke Universiteit, Leuven, Belgium.
- We have demonstrated that, in addition to their contractile function, human airway smooth-muscle cells (HASMC) are able to express and to secrete chemokines of the monocyte chemotactic protein (MCP)/ eotaxin subfamily. This group of chemokines is believed to play a fundamental role in the development of allergic airwa
- [Meningitis by Cryptococcus neoformans in patients with HIV infection]
- Neurologia. 1999 May;14(5):218-23. Unique Identifier : AIDSLINE MED/99305485
- Martinez Fernandez EM; Lopez-Cortes LF; Regordan C; Cordero Matia E; Servicio de Neurologia, Hospital Universitario Virgen del; Rocio, Sevilla. evamtnez@arrakis.es
- OBJECTIVE: To review a serie of patients with cryptococcal meningitis and immunodeficiency syndrome (AIDS) treated in our hospital in the last two years. PATIENTS AND METHODS: Retrospective study of 25 patients infected with the human immunodeficiency virus (HIV) and affected by Cryptococcus neoformans meningitis. The
- Using cross-cultural input to adapt the Functional Assessment of Chronic Illness Therapy (FACIT) scales.
- Acta Oncol. 1999;38(6):695-702. Unique Identifier : AIDSLINE MED/99450594
- Lent L; Hahn E; Eremenco S; Webster K; Cella D; Center on Outcomes, Research and Education, Evanston Northwestern; Healthcare, Evanston, IL 60201, USA.
- Cross-cultural quality of life measurement and psychosocial assessment in oncology have become reality with the translation and international validation of quality of life questionnaires. The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System, under development since 1987, produced its 4th ver
- Controlled management of public relations following a public health incident.
- J Public Health Med. 1999 Sep;21(3):251-4. Unique Identifier : AIDSLINE MED/99456219
- Holdsworth GM; Breathnach A; Asboe D; Free D; Cranston R; Peters BS; de Ruiter A; Department of Public Health and Health Policy, Lambeth, Southwark; and Lewisham Health Authority, London.
- This paper describes the management of public relations following an outbreak of multidrug resistant TB at a London hospital. Eight patients were involved, all of the secondary cases occurred in HIV seropositive patients, and three cases died. The paper describes how the the Incident Committee undertook to recall cont
- What is the cost of getting the price wrong?
- J Public Health Med. 1999 Sep;21(3):311-7. Unique Identifier : AIDSLINE MED/99456227
- Beck EJ; Beecham J; Mandalia S; Griffith R; Walters MD; Boulton M; Miller DL; Department of Epidemiology and Public Health, Imperial College; School of Medicine, London.
- BACKGROUND: The objective of this study was to compare differences in cost estimates for paediatric HIV hospital service provision based on hospital prices with cost estimates obtained through a research-based service-specific costing exercise. METHODS: Activity data on the use of hospital services of children by stag
- Quarterly communicable disease review January to March 1999. From the PHLS Communicable Disease Surveillance Centre. Public Health Laboratory Service.
- J Public Health Med. 1999 Sep;21(3):348-54. Unique Identifier : AIDSLINE MED/99456232
- Catchpole M; Hamilton G; Hawker J; Olowokure B; Ramsay M; Weinberg J; Weild A
- Characteristic distribution of HTLV type I and HTLV type II carriers among native ethnic groups in South America.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1235-9. Unique Identifier : AIDSLINE MED/99433490
- Fujiyoshi T; Li HC; Lou H; Yashiki S; Karino S; Zaninovic V; Oneegllo SG; Camacho M; Andrade R; Hurtado LV; Gomez LH; Damiani E; Cartier L; Dipierri JE; Hayami M; Sonoda S; Tajima K; Department of Virology, Faculty of Medicine, Kagoshima; University, Japan.
- To confirm the geographic and ethnic segregation of HTLV-I and HTLV-II carriers in native populations in South America, we have conducted a seroepidemiological study of native populations in South America, including HTLV-I carriers distributed among seven ethnic groups in the Andes highlands of
- Chloroquine exerts an additive in vitro anti-HIV type 1 effect when associated with didanosine and hydroxyurea.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1241-7. Unique Identifier : AIDSLINE MED/99433491
- Boelaert JR; Sperber K; Piette J; Unit for Renal and Infectious Diseases, Algemeen Ziekenhuis; St-Jan, Brugge, Belgium. j.r.boelaert.brugge@unicall.be
- Several groups, including ours, have reported that chloroquine (CQ) or its analog hydroxychloroquine has anti-HIV-1 activity both in vitro and in vivo. We studied in vitro whether the addition of CQ to the combination of hydroxyurea (HU) plus didanosine (ddI) had an additive effect in inhibiting the replication of HIV
- Long-term effects of antiretroviral combination therapy on HIV type 1 DNA levels.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1249-54. Unique Identifier : AIDSLINE MED/99433492
- Aleman S; Visco-Comandini U; Lore K; Sonnerborg A; Division of Clinical Virology, Institution of Immunology,; Microbiology, Pathology, and Infectious Diseases, Karolinska; Institute, Huddinge University Hospital, Huddinge/Stockholm,; Sweden.
- HIV-1 RNA and DNA levels were measured in 58 patients, of whom 37 and 11, respectively, received triple or double combination therapy . At baseline, strong correlations were found between the number of HIV-1 DNA copies per 106 CD4+ cells, the plasma HIV-1 RNA levels, an
- The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4+ T cells.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1255-63. Unique Identifier : AIDSLINE MED/99433493
- Bottarel F; Feito MJ; Bragardo M; Bonissoni S; Buonfiglio D; DeFranco S; Malavasi F; Bensi T; Ramenghi U; Dianzani U; Department of Medical Sciences, A. Avogadro University of Eastern; Piedmont at Novara, Italy.
- CD4 cross-linking by HIV gp120 triggers CD4+ T cell death. Several authors have suggested that this effect is mediated by CD95, but this possibility is debated by other authors. In a previous work, we found by co-capping that gp120(451) and gp120MN, but not gp120(IIIB), induce lateral association of CD4 with CD95 on t
- Effect of extracellular human immunodeficiency virus type 1 glycoprotein 120 on primary human vascular endothelial cell cultures.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1265-77. Unique Identifier : AIDSLINE MED/99433494
- Huang MB; Hunter M; Bond VC; Department of Biochemistry, Morehouse School of Medicine,; Atlanta, Georgia 30087-1495, USA.
- During the course of an HIV-1 infection, free infectious and noninfectious virus particles, and free HIV-1 proteins, circulate within the host, exposing the host endothelium to these viral factors, even if the endothelium is not infected. This suggests that extracellular HIV-1 proteins could influence endothelial cell
- Chemokine pattern in relation to disease state in human immunodeficiency virus-infected children.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1279-85. Unique Identifier : AIDSLINE MED/99433495
- Than S; Tumaliuan JA; Tamma S; Morales M; Bakshi S; Pahwa S; Department of Pediatrics, North Shore University Hospital-New; York University School of Medicine, Manhasset 11030, USA.
- Although beta chemokines can block human immunodeficiency virus (HIV) entry into target cells, their role in HIV disease progression is controversial. To determine the association of RANTES with HIV disease state, we examined constitutive mRNA expression by reverse-transcribed polymerase chain reaction (RT-PCR) in per
- Rapid detection of the HIV type 1 reverse transcriptase codon T215Y by reverse transcription-polymerase chain reaction with fluorogenic probes.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1287-92. Unique Identifier : AIDSLINE MED/99433496
- Ross L; Vavro C; Zimmermann A; St. Clair M; Department of Virology, Glaxo Wellcome, Research Triangle Park,; North Carolina 27709, USA. llr8156@glaxowellcome.com
- Early detection of viral mutations, particularly those mutations associated with cross-resistance to antiretroviral drugs, is critical both for understanding the mechanism of drug resistance and for the clinical management of patients infected with HIV-1. One of the frequently observed mutations in the HIV-1 reverse t
- Long terminal repeat promoter/enhancer activity of different subtypes of HIV type 1.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1293-303. Unique Identifier : AIDSLINE GENBANK/AF102226
- Naghavi MH; Schwartz S; Sonnerborg A; Vahlne A; Department of Immunology, Microbiology, Pathology, and Infectious; Diseases, Karolinska Institute, Huddinge University Hospital,; Huddinge/Stockholm, Sweden. muna@lab01.hs.sll.se
- Transcription of the HIV-1 provirus genome is regulated by a complex interplay between viral regulatory proteins and cellular transcription factors that interact with the viral long terminal repeat (LTR) region of HIV-1. However, several cellular transcription factors have been identified that can interact with the HI
- The dendritic cell-T cell milieu of the lymphoid tissue of the tonsil provides a locale in which SIV can reside and propagate at chronic stages of infection.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1305-14. Unique Identifier : AIDSLINE MED/99433498
- Hu J; Miller CJ; O'Doherty U; Marx PA; Pope M; California Regional Primate Research Center, University of; California, Davis 95616, USA.
- Previous studies described the presence of numerous human immunodeficiency virus (HIV)-positive cells within and just beneath the mucosal surfaces of the tonsillar tissue of HIV-1-infected individuals. The virus-positive cells were most abundant in the dendritic cell (DC)-T cell rich areas of the lymphoepithelia linin
- Sequences and predicted structures of chimpanzee STRL33 (Bonzo) and gpr15 (BOB).
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1315-9. Unique Identifier : AIDSLINE MED/99433499
- Brussel A; Pretet JL; Girard M; Butor C; Laboratoire d'Immunologie des Pathologies Infectieuses et; Tumorales, INSERM U445, Institut Cochin de Genetique; Moleculaire, Universite Rene Decartes, Paris, France.
- An infectious DNA clone of HIV type 1 subtype C.
- AIDS Res Hum Retroviruses. 1999 Sep 20;15(14):1321-4. Unique Identifier : AIDSLINE GENBANK/AB023804
- Mochizuki N; Otsuka N; Matsuo K; Shiino T; Kojima A; Kurata T; Sakai K; Yamamoto N; Isomura S; Dhole TN; Takebe Y; Matsuda M; Tatsumi M; Department of Pathology, Research Institute, International; Medical Center of Japan, Toyama, Tokyo.
- Among the 10 subtypes of the M group of human immunodeficiency virus type 1, subtype C is the most prevalent in India and may dominate worldwide in the near future; however, there has been no report on the infectious DNA clone of this subtype. We have isolated an infectious DNA clon
- Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines.
- Eur J Cancer. 1999 Jun;35(6):1027-34. Unique Identifier : AIDSLINE MED/20003682
- Murakami J; Nagai N; Shigemasa K; Ohama K; Department of Obstetrics and Gynecology, Hiroshima University; School of Medicine, Japan.
- Telomerase is a ribonucleoprotein which has a RNA template to bind and extend telomere ends, so prolonging the life of tumour cells. The aim of this study was to determine whether transcriptase function of telomerase could be inhibited by the reverse transcriptase inhibitors (RTI); azydothymidine (
- Comparative analysis of quantification of viral load in patients infected with hepatitis C virus: quantiplex HCV RNA assay and amplicor monitor assay.
- Rev Esp Enferm Dig. 1999 Aug;91(8):569-82. Unique Identifier : AIDSLINE MED/99423573
- Olaso V; Cordoba J; Lopez B; Arguello L; Molina J; Lainez B; Ortiz V; Pastor M; Prieto M; Berenguer J; Servicio de Medicina Digestiva, Hospital "La Fe", Valencia,; 46009, Espana.
- OBJECTIVE: two standardized techniques, Quantiplex HCV RNA 2.0 (bDNA) and Amplicor Monitor, were evaluated for the quantification of hepatitis C virus (HCV) load. Our objectives were: 1) to determine the relationship between viral load and genotype, and 2) to evaluate viral load in serial serum samples and in patients
- Coping strategies of HIV-positive and HIV-negative female injection drug users: a longitudinal study.
- AIDS Educ Prev. 1999 Oct;11(5):373-88. Unique Identifier : AIDSLINE MED/20022548
- Brook DW; Brook JS; Richter L; Whiteman M; Win PT; Masci JR; Roberto J; Department of Community and Preventive Medicine, Mount Sinai; School of Medicine, New York, NY 10029, USA.
- This study longitudinally examined the psychosocial correlates of coping strategies among 165 HIV positive and 179 HIV negative female injection drug users (IDUs). Participants were interviewed twice using a structured questionnaire, with a 6-month interval between interviews. The questionnaire included psychosocial m
- Improving comprehension and recall of information for an HIV vaccine trial among women at risk for HIV: reading level simplification and inclusion of pictures to illustrate key concepts.
- AIDS Educ Prev. 1999 Oct;11(5):389-99. Unique Identifier : AIDSLINE MED/20022549
- Murphy DA; O'Keefe ZH; Kaufman AH; Health Risk Reduction Projects, Department of Psychiatry,; University of California, Los Angeles 90024, USA.; dmurphy@mednet.ucla.edu
- A simplified version of the prototype HIV vaccine material was developed through (a) reducing reading grade level, (b) restructuring of the organization and categorization of the material, (c) adding pictures designed to emphasize key concepts, and (d) obtaining feedback on the simplified version through focus groups
- A scale to measure attitudes about HIV-antibody testing: development and psychometric validation.
- AIDS Educ Prev. 1999 Oct;11(5):400-13. Unique Identifier : AIDSLINE MED/20022550
- Boshamer CB; Bruce KE; Department of Psychology, University of North Carolina at; Wilmington, 28403, USA.
- Testing for antibodies to HIV is a vital component of many AIDS prevention and intervention programs. To increase the use of HIV antibody testing, it is important to understand more about peoples attitudes about testing so that intervention programs can focus on the specific concerns of the target population. A scale
- Consensus theory model of AIDS/SIDA beliefs in four Latino populations.
- AIDS Educ Prev. 1999 Oct;11(5):414-26. Unique Identifier : AIDSLINE MED/20022551
- Trotter RT 2nd; Weller SC; Baer RD; Pachter LM; Glazer M; Garcia de Alba Garcia JE; Klein RE; Northern Arizona University, Flagstaff, USA.
- To describe Latino beliefs about AIDS (SIDA), Latino adults were sampled at two U.S. sites (Connecticut and Texas) and two international sites ( Mexico and Guatemala ). A 125-item questionnaire covered risk factors, symptoms, treatments, and se
- Aspects of motivation of a volunteer AIDS care team program.
- AIDS Educ Prev. 1999 Oct;11(5):427-35. Unique Identifier : AIDSLINE MED/20022552
- Christensen LA; Reininger BM; Richter DL; McKeown RE; Jones A; Classics of Charleston, Ltd, SC 29401, USA. lachris@innova.net
- The South Carolina AIDS Care Team Program, directed by The Ecumenical AIDS Ministry, a component of the South Carolina Christian Action Council, provides emotional and supportive services to people living with HIV and AIDS. A sample of volunteer care team members participated in five focus groups as part of a process
- African-American volunteers carrying an HIV prevention message: selective communication.
- AIDS Educ Prev. 1999 Oct;11(5):436-49. Unique Identifier : AIDSLINE MED/20022553
- Davison DM; Reeder GD; Teverbaugh K; Department of Social Work, Illinois State University, Normal; 61790, USA. dmdavis@ilstu.edu
- Despite increased resources and funding, the rate of new HIV infections has not been contained within the African American community. Initiatives such as the culturally specific American Red Cross African American HIV/AIDS Program have enlisted thousands of volunteers in the fight against AIDS. This article reports th
- AIDS knowledge, condom attitudes, and risk-taking sexual behavior of substance-abusing juvenile offenders on probation or parole.
- AIDS Educ Prev. 1999 Oct;11(5):450-61. Unique Identifier : AIDSLINE MED/20022554
- Robertson A; Levin ML; Social Science Research Center, Mississippi State University,; Mississippi State 39762, USA. angela.robertson@ssrc.msstate.edu
- AIDS knowledge, condom attitudes, and sexual behavior were examined in a sample of 193 substance-abusing juvenile offenders on probation or parole. The majority of these youths reported being sexually active, and many admitted to early onset of sexual activity as well as unsafe sexual practices. Potential predictors o
- Selenium-dependent glutathione peroxidase modules encoded by RNA viruses.
- Biol Trace Elem Res. 1999 Nov;70(2):97-116. Unique Identifier : AIDSLINE MED/20004178
- Zhang W; Ramanathan CS; Nadimpalli RG; Bhat AA; Cox AG; Taylor EW; Computational Center for Molecular Structure and Design, and; Department of Pharmaceutical and Biomedical Sciences, The; University of Georgia, Athens 30601-2352, USA.
- Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven
- Effect of HIV-1 gp41 peptides on secretion of beta-amyloid precursor protein in human astroglial cell line, T98G.
- J Mol Neurosci. 1999 Apr;12(2):147-56. Unique Identifier : AIDSLINE MED/99454582
- Chong YH; Lee MJ; Department of Microbiology, College of Medicine, Ewha Womans; University, Seoul, Korea.
- To understand the mechanism underlying cognitive deficits in AIDS patients, we examined the influence of gp41 peptides on the expression and the secretion of Alzheimer s amyloid precursor protein (APP) in human astroglial cell line T98G. Western blotting analyses demonstrated that treatment of glial cells with a putat
- Myelodysplastic syndrome in a patient with adult T-cell leukaemia.
- Br J Haematol. 1999 Sep;106(3):702-5. Unique Identifier : AIDSLINE MED/99398085
- Kawabata H; Utsunomiya A; Hanada S; Makino T; Takatsuka Y; Takeuchi S; Suzuki S; Suzumiya J; Ohshima K; Horiike S; Department of Haematology, Imamura Bun-in Hospital, Kagoshima.
- A 53-year-old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T-cell leukaemia (ATL) is described. The latent period of therapy-related MDS (t-MDS) from the time of diagnosis of ATL was approximately 35 months. Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t
- Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) DNA sequences are absent in leukapheresis products and ex vivo expanded CD34+ cells from multiple myeloma patients.
- Br J Haematol. 1999 Sep;106(4):1033-6. Unique Identifier : AIDSLINE MED/99451301
- De Greef C; Van De Voorde W; Bakkus M; Corthals J; Heirman C; Schots R; Lacor P; Van Camp B; Van Riet I; Department of Haematology-Immunology, Free University of; Brussels, Belgium.
- Recently it was reported that Kaposi s sarcoma-associated herpesvirus (KSHV/HHV-8) infects bone marrow (BM) dendritic cells (DC) in multiple myeloma (MM) patients and therefore might play a role in MM development. Because of the use of myeloid growth factors like GM-CSF and G-CSF for the mobilization of peripheral blo
- Hepatitis C infection and B-cell non-Hodgkin's lymphoma in British Columbia: a cross-sectional analysis.
- Ann Oncol. 1999 Aug;10(8):961-4. Unique Identifier : AIDSLINE MED/99438575
- Shariff S; Yoshida EM; Gascoyne RD; Le N; Connors JM; Middleton PJ; Shenkier TN; Department of Medicine, University of British Columbia, Canada.
- OBJECTIVES: To determine the prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin s lymphoma (NHL) in British Columbia. DESIGN: A cross-sectional analysis. SETTING: The British Columbia Cancer Agency (BCCA), a Canadian provincial tertiary oncology ref
- The potential importance of HIV-induction of lymphocyte homing to lymph nodes.
- Int Immunol. 1999 Oct;11(10):1591-4. Unique Identifier : AIDSLINE MED/99437880
- Chen JJ; Cloyd MW; Departments of Microbiology-Immunology and Pathology, University; of Texas Medical Branch, Galveston, TX 77555, USA.
- The mechanism by which HIV causes depletion of CD4 lymphocytes remains unknown. Recent studies have demonstrated that HIV binding to resting CD4 lymphocytes causes them to home from the blood into lymph node, and during the homing process, they are induced into apoptosis only to secondary signals through the homing re
- Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8 lineage cells.
- Int Immunol. 1999 Oct;11(10):1595-600. Unique Identifier : AIDSLINE MED/99437881
- Rooke R; Waltzinger C; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et Cellulaire; (CNRS/INSERM/ULP), 67404 Illkirch, CU de Strasbourg, France.
- Recombinant adenovirus vectors are powerful tools for inducing de novo gene expression in vivo. Here we have exploited them to study the specificity of CD4/CD8 lineage commitment during thymocyte positive selection, transferring MHC class II genes directly into thymi of mice deficient in both class I and II molecules.
- Acute cellular rejection of human renal tissue by adoptive transfer of allogeneic human peripheral blood mononuclear cells into chimeric rats: sequential gene expression of cytokines, chemokines and cytolytic effector molecules, and their regulation by CTLA-4-Ig.
- Int Immunol. 1999 Oct;11(10):1673-83. Unique Identifier : AIDSLINE MED/99437889
- Dekel B; Bocher WO; Marcus H; Yussim A; Reisner Y; Department of Immunology, The Weizmann Institute of Science,; Rehovot 76100, Israel.
- T(h)1- and T(h)2-related cytokines (IFN-gamma, IL-2 , IL-4, IL-10), beta-chemokines (RANTES, macrophage inflammatory protein-1beta) and their receptor [chemotatic cytokine receptor (CCR) 5], and the cytolytic effector molecule [Fas ligand (FasL)] play an essential role
- NMR structure of the complex between the zinc finger protein NCp10 of Moloney murine leukemia virus and the single-stranded pentanucleotide d(ACGCC): comparison with HIV-NCp7 complexes.
- Biochemistry. 1999 Oct 5;38(40):12984-94. Unique Identifier : AIDSLINE PDB/1A6B
- Schuler W; Dong C; Wecker K; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale,; INSERM U266-CNRS UMR 8600, UFR des Sciences Pharmaceutiques et; Biologiques, Paris, France.
- The structure of the 56 amino acid nucleocapsid protein NCp10 of retrovirus MoMuLV, which contains a single CX(2)CX(4)HX(4)C-type zinc finger, has been determined previously by NMR. The important role of NCp10 (or NCp7 for HIV-1) in the retroviral life cycle seems mainly related to their preferential binding to single
- Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression.
- Biochemistry. 1999 Oct 5;38(40):13055-62. Unique Identifier : AIDSLINE MED/99459250
- Taher MM; Baumgardner T; Dent P; Valerie K; Department of Radiation Oncology, Massey Cancer Center, Medical; College of Virginia, Virginia Commonwealth University, Richmond; 23298-0058, USA.
- We have examined the role of stress-activated p38 MAP kinase in regulating human immunodeficiency virus (HIV) gene expression in response to ultraviolet light (UV). We found that UV activated p38 in HeLa cells harboring stably integrated copies of an HIVcat plasmid to levels similar to those obtained by hyperosmotic s
- Inhibitors of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.
- Biochemistry. 1999 Oct 5;38(40):13070-6. Unique Identifier : AIDSLINE MED/99459252
- Gabbara S; Davis WR; Hupe L; Hupe D; Peliska JA; Department of Biological Chemistry, University of Michigan; Medical School, Ann Arbor 48109-0606, USA.
- The discovery and characterization of new inhibitors of HIV-1 reverse transcriptase (RT) is an important step toward understanding the mechanism of this multifunctional polymerase. We describe the identification of novel inhibitors of HIV-1 RT-catalyzed reactions utilizing a nucleic acid model system designed to mimic
- Reversible S-nitrosation and inhibition of HIV-1 protease.
- Biochemistry. 1999 Oct 5;38(40):13407-13. Unique Identifier : AIDSLINE MED/99459292
- Sehajpal PK; Basu A; Ogiste JS; Lander HM; Department of Biochemistry, Weill Medical College of Cornell; University, New York 10021, USA.
- Nitric oxide (*NO) is a short-lived free radical with many functions including vasoregulation, synaptic plasticity, and immune modulation and has recently been associated with AIDS pathology. Various pathophysiological conditions, such as viral infection, trigger inducible nitric oxide synthase (iNOS) to synthesize NO
- Drinking perceptions and drinking behaviors among urban black adolescents.
- J Adolesc Health. 1999 Oct;25(4):264-75. Unique Identifier : AIDSLINE MED/99433663
- Strunin L; Social and Behavioral Sciences Department, Boston University; School of Public Health, Massachusetts 02118-2526, USA.
- PURPOSE: To improve understanding of black (African American and Haitian Blacks) adolescents drinking behaviors and sexual patterns that put them at risk for human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) to determine whether specific cultural differences affect beliefs and behaviors about
- An exploratory attempt to distinguish subgroups among crack-abusing African-American women.
- J Addict Dis. 1999;18(3):41-54. Unique Identifier : AIDSLINE MED/99435415
- Cohen ED; Department of Sociology, Pennsylvania State University, Uniontown; 15401, USA. edcl@psu.edu
- Despite the significant emergence of research on female addiction over the last two decades, specific research on African-American women substance abusers, particularly crack cocaine users, is limited. The identification of meaningful subgroups of substance abusing populations, particularly minority women is important
- Poverty, disease progression and employment among people living with HIV/AIDS in Australia.
- AIDS Care. 1999 Aug;11(4):405-14. Unique Identifier : AIDSLINE MED/20003726
- Ezzy D; de Visser R; Bartos M; University of Tasmania, Melbourne, Australia.; Douglas.Ezzy@utas.edu.au
- A national survey of 925 people living with HIV/AIDS (PLWHA) in Australia is used to examine the relationship between disease progression, employment status, poverty and economic hardship. While disease progression has some impact on economic hardship, employment status is found
- Psychological and social correlates of high-risk sexual behaviour among men and women living with HIV/AIDS.
- AIDS Care. 1999 Aug;11(4):415-27. Unique Identifier : AIDSLINE MED/20003727
- Kalichman SC; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin 53226, USA.
- Men and women living with HIV/AIDS who experience difficulty maintaining safer sex practices place their sex partners as well as themselves at considerable risk for sexually transmitted infections. Psychological correlates of continued sexual risk behaviours provide important information for intervention development.
- Lack of legal income is strongly associated with an increased risk of AIDS and death in HIV-infected injecting drug users.
- AIDS Care. 1999 Aug;11(4):429-36. Unique Identifier : AIDSLINE MED/20003728
- Piketty C; Castiel P; Giral P; Lhomme JP; Boubilley D; Olievenstein C; Lert F; Kazatchkine MD; Unite d'Immunologie, Hopital Broussais, Universite Pierre et; Marie Curie, Paris, France.; Christophe.piketty@brs.ap-hop-paris.fr
- The aim of the study was to analyze the impact of soci-economic status in addition to other risk factors in the progression of HIV disease in a cohort of injecting drug users (IDUs) with a mean follow-up of two years. Between 1989 and 1992, 124 HIV-infected IDUs were recruited in a primary care outpatient clinic provi
- Geographic proximity, policy and utilization of syringe exchange programmes.
- AIDS Care. 1999 Aug;11(4):437-42. Unique Identifier : AIDSLINE MED/20003729
- Rockwell R; Des Jarlais DC; Friedman SR; Perlis TE; Paone D; National Development and Research Institutes, Inc., New York; 10048, USA.
- The objective of the research was to assess the effects of geographic proximity on the utilization of syringe exchange among injection drug users (IDUs) in New York City. Between 1994 and 1996, 805 IDUs were interviewed with a structured questionnaire. Geographic proximity was defined as living within a ten-minute wal
- AIDS-related information exposure in the mass media and discussion within social networks among married women in Bombay, India.
- AIDS Care. 1999 Aug;11(4):443-6. Unique Identifier : AIDSLINE MED/20003730
- Chatterjee N; School of Public Health, University of Texas Health Science; Center, Houston 77225, USA. sph1974@utsph.sph.uth.tmc.edu
- Married women are at high risk of acquiring HIV infection in India and health education remains the most feasible preventive tool in their context. In a survey conducted among 350 married women in Bombay, it was found that a majority had acquired information about AIDS from the mass
- The parent disclosure interview.
- AIDS Care. 1999 Aug;11(4):447-52. Unique Identifier : AIDSLINE MED/20003731
- Pilowsky DJ; Sohler N; Susser E; Department of Psychiatry, Johns Hopkins University School of; Medicine & Kennedy-Krieger Institute, Baltimore, MD, USA.; pilowsky@kennedykrieger.org
- As the number of HIV-infected women and children in the USA has increased, clinicians and researchers have debated the benefits and risks of disclosure of parental HIV status to children. Disclosure is usually ascertained through interviews of unknown reliability. Given the need to advance knowledge regarding the bene
- Development of the Impact of Weight Loss Scale (IWLS): a psychometric study in a sample of men with HIV/AIDS.
- AIDS Care. 1999 Aug;11(4):453-7. Unique Identifier : AIDSLINE MED/20003732
- Wagner GJ; Rabkin JG; Department of Psychiatry, New York State Psychiatric Institute,; NY 10032, USA. wagnerg@pi.cpmc.columbia.edu
- The purpose of this study was to assess the psychometric properties of the newly developed Impact of Weight Loss Scale (IWLS), a subjective measure of perceived weight loss and related behaviour, body image perception, and affect, as well as the scale s relationship to mental health and nutritional measures in an HIV
- Knowledge, attitudes and practices concerning HIV/AIDS among sex workers in Phnom Penh, Cambodia.
- AIDS Care. 1999 Aug;11(4):459-72. Unique Identifier : AIDSLINE MED/20003733
- Prybylski D; Alto WA; Department of Epidemiology and Preventive Medicine, University of; Maryland School of Medicine, Baltimore 21201-1596, USA.; dprybyls@epi.umaryland.edu
- The human immunodeficiency virus (HIV)/AIDS epidemic is currently spreading faster in Cambodia than anywhere else in Asia. Heterosexual transmission of HIV through prostitution is believed to be catalyzing the epidemic, and sex workers (SWs) are at a very high risk for becoming i
- Contrasting strategies used by young people to ensure condom use: some findings from a qualitative research project.
- AIDS Care. 1999 Aug;11(4):473-9. Unique Identifier : AIDSLINE MED/20003734
- Coleman L; Ingham R; Department of Psychology, University of Southampton, UK.; LMC3@PSY.SOTON.AC.UK
- Interviews conducted among 56 young men and women (aged 16-19) reveal two contrasting strategies used to ensure condom use at first intercourse with a new partner. These are defined as verbal communication based strategies (involving some explicit discussion about contraception before intercourse) and non-verbal commu
- Caring for people with HIV in Zambia: are traditional healers and formal health workers willing to work together?
- AIDS Care. 1999 Aug;11(4):481-91. Unique Identifier : AIDSLINE MED/20003735
- Burnett A; Baggaley R; Ndovi-MacMillan M; Sulwe J; Hang'omba B; Bennett J; Department of General Practice, St. Bartholomew's and the Royal; London Hospital Medical College, UK. a.c.burnett@qmw.ac.uk
- This study of traditional healers and formal health workers determined their knowledge and practices in the field of HIV/AIDS and examined their training needs and attitudes to collaboration, in preparation for planning joint training workshops. Several misconceptions concerning symptoms and transmission of HIV diseas
- Virus-associated lymphomas [see comments]
- Curr Opin Oncol. 1999 Sep;11(5):322-32. Unique Identifier : AIDSLINE MED/99433586
- Cesarman E; Mesri EA; Department of Pathology, Weill Medical College of Cornell; University and The New York Presbyterian Hospital, NY 10021, USA.
- Epstein-Barr virus, Kaposi s sarcoma-associated herpesvirus/human herpesvirus 8, and human T-cell lymphotrophic virus are viruses that are implicated in lymphoid neoplasia in humans. Their association with specific subsets of lymphomas suggests that they play an important, although not sufficient, etiologic role in th
- Recent advances in the molecular pathogenesis of lymphomas [see comments]
- Curr Opin Oncol. 1999 Sep;11(5):351-63. Unique Identifier : AIDSLINE MED/99433590
- Sarris A; Ford R; Department of Lymphoma and Myeloma, The University of Texas M.D.; Anderson Cancer Center, Houston 77030, USA.; asarris@notes.mdacc.tmc.edu
- Most human lymphomas remain heterogeneous biologic entities in spite of recent advances in the description of their clinical presentation, cellular morphology, immunophenotype, and genotype. Elucidation of genetic alterations causing malignant transformation may explain pathogenesis, refine differential diagnosis, cla
- Acquired constitutive expression of interferon beta after gene transduction enhances human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity by a RANTES-dependent mechanism.
- Hum Gene Ther. 1999 Jul 20;10(11):1803-10. Unique Identifier : AIDSLINE MED/99374586
- Hadida F; De Maeyer E; Cremer I; Autran B; Baggiolini M; Debre P; Vieillard V; Laboratoire d'Immunologie Cellulaire, UMR 7627 CNRS, Hopital; Pitie-Salpetriere, Paris, France. Hadida@ccr.jussieu.fr
- CTL lines directed against HIV-1 antigens were generated from infected individuals and were transduced by the HMB-K(b)HuIFNbeta vector, resulting in low, constitutive expression of interferon beta (IFN-beta). The IFN-beta-transduced cells showed markedly increased HIV-1-specific, MHC class I-restricted CTL activity ag
- A phase I trial of autologous CD34+ hematopoietic progenitor cells transduced with an anti-HIV ribozyme.
- Hum Gene Ther. 1999 Sep 1;10(13):2255-70. Unique Identifier : AIDSLINE MED/99426544
- Amado RG; Mitsuyasu RT; Symonds G; Rosenblatt JD; Zack J; Sun LQ; Miller M; Ely J; Gerlach W; Department of Medicine and UCLA AIDS Institute, Los Angeles, CA; 90095-1678, USA.
- Conferral of an antiviral state to CD4+ cells by a zipper motif envelope mutant of the human immunodeficiency virus type 1 transmembrane protein gp41.
- Hum Gene Ther. 1999 Sep 20;10(14):2381-95. Unique Identifier : AIDSLINE MED/99443481
- Chuang CK; Lee SF; Chen SS; Division of Infectious Diseases, Institute of Biomedical; Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
- We showed in a transient coexpression study that a single proline substitution for any of the five conserved leucine or isoleucine residues located in the envelope (Env) transmembrane protein gp41 zipper motif of the human immunodeficiency virus type 1 dominantly interferes with wild-type Env-mediated viral infectivit
- Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat.
- Hum Gene Ther. 1999 Oct 10;10(15):2505-14. Unique Identifier : AIDSLINE MED/20008960
- Poznansky MC; La Vecchio J; Silva-Arietta S; Porter-Brooks J; Brody K; Olszak IT; Adams GB; Ramstedt U; Marasco WA; Scadden DT; Partners AIDS Research Center, Massachusetts General Hospital,; Harvard Medical School, Boston 02129, USA.
- Current clinical gene therapy protocols for the treatment of human immunodeficiency virus type 1 (HIV-1) infection involve the ex vivo transduction and expansion of CD4+ T cells derived from HIV-positive patients at a late stage in their disease (CD4+ cell count
- Alcohol use in HIV patients: what we don't know may hurt us.
- Unique Identifier : AIDSLINE MED/99420171
- Petry NM
- Our objectives are to evaluate the prevalence of and problems associated with alcohol use disorders among HIV patients. We review the literature on alcohol use and HIV. Rates of alcohol use disorders are high among HIV patients. The co-occurrence of
- Update on the treatment of sexually transmitted infections in pregnancy--1.
- Int J STD AIDS. 1999 Sep;10(9):571-8; quiz 579-81. Unique Identifier : AIDSLINE MED/99420172
- Brocklehurst P; Unit Epidemiologist, Radcliffe Infirmary, Oxford, UK.; Peter.brocklehurst@perinat.ox.ac.uk
- HIV-associated risk factors among young Canadian Aboriginal and non-Aboriginal men who have sex with men.
- Int J STD AIDS. 1999 Sep;10(9):582-7. Unique Identifier : AIDSLINE MED/99420173
- Heath KV; Cornelisse PG; Strathdee SA; Palepu A; Miller ML; Schechter MT; O'Shaughnessy MV; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, Canada.
- Young Aboriginal men face marginalization distinct in cause but similar in pattern to those seen among men who have sex with men (MSM) and may be at increased risk for HIV infection. We compared sociodemographic characteristics and risk taking behaviours associated with HIV infection among MSM of Aboriginal and non-Ab
- A one-year survey of gonococcal infection seen in the genitourinary medicine department of a London district general hospital.
- Int J STD AIDS. 1999 Sep;10(9):588-94. Unique Identifier : AIDSLINE MED/99420174
- Lewis DA; Bond M; Butt KD; Smith CP; Shafi MS; Murphy SM; Genitourinary Medicine Department, London, UK.
- The results of a one-year clinical, epidemiological and microbiological survey of gonococcal infection presenting to the Patrick Clements Clinic (PCC), a London district general hospital (DGH) genitourinary medicine (GUM) clinic, are presented. Clinical and epidemiological patient data were collected by a combination
- A prospective study of pharyngeal gonorrhoea and inconsistent condom use for oral sex among female brothel-based sex workers in Singapore.
- Unique Identifier : AIDSLINE MED/99420175
- Wong ML; Chan RK; Department of Community, Occupational and Family Medicine,; Faculty of Medicine, National University of Singapore, Singapore.; cofwml@leonis.nus.edu.sg
- Oral sex among female sex workers in Singapore has risen sharply from 27.1% in 1992 to 81.7% in 1997. A prospective cohort study was carried out on 724 female brothel-based sex workers who practised oral sex, to determine the risk of contracting pharyngeal gonorrhoea through inc
- Gay men's stereotypes about who is HIV infected: a further study.
- Int J STD AIDS. 1999 Sep;10(9):600-5. Unique Identifier : AIDSLINE MED/99420176
- Gold RS; Skinner MJ; Hinchy J; School of Psychology, Deakin University, Burwood, Victoria,; Australia.
- Gay men s stereotypes about who is HIV-infected were investigated. Young uninfected (n=62), older uninfected (n=61), and infected (n=65) gay men read brief descriptions of men they did not know and estimated the likelihood that they were infected. Each description highlighted one characteristic of the man described. T
- Acid-alcohol fast bacilli in sputa of HIV-infected patients.
- Int J STD AIDS. 1999 Sep;10(9):606-8. Unique Identifier : AIDSLINE MED/99420177
- Sullivan AK; Hannan MM; Azadian BS; Easterbrook PJ; Gazzard BG; Nelson MR; St Stephen's Centre, Chelsea and Westminster Hospital, London,; UK. anns@crusaid-star.co.uk
- We identified 34 HIV-infected patients with sputum smear positive for acid-alcohol fast bacilli (AAFB) to determine any factors predictive of subsequent species identification. There were 20 cases of Mycobacterium tuberculosis (MTB), 9 cases of Mycobacterium avium-intracellulare (MAI), 3 cases of Mycobacterium kansasi
- Sexually transmitted infections in young pregnant women in Bangui, Central African Republic.
- Int J STD AIDS. 1999 Sep;10(9):609-14. Unique Identifier : AIDSLINE MED/99420178
- Blankhart D; Muller O; Gresenguet G; Weis P; Deutsche Gesellschaft fur Technische Zusammenarbeit, Eschborn,; Germany.
- In early 1996, 481 women visiting the antenatal services of the 3 major governmental health centres in the capital city of the Central African Republic (CAR) were included in the study. All study participants underwent the health centre s routine gynaecological exam
- PCR detection of Epstein-Barr virus, herpes simplex virus and human papillomavirus from the anal mucosa in HIV-seropositive and HIV-seronegative homosexual men.
- Int J STD AIDS. 1999 Sep;10(9):615-8. Unique Identifier : AIDSLINE MED/99420179
- Lowhagen GB; Bergbrant IM; Bergstrom T; Ryd W; Voog E; Department of Dermato-Venereology, Sahlgrenska University; Hospital, Goteborg, Sweden.
- This study aimed to examine the prevalence of the Epstein-Barr virus (EBV), herpes simplex virus (HSV) and human papillomavirus (HPV) in the anal and oral mucosa of homosexual men with and without HIV infection and to correlate these findings to CD4+ count and anal cytology. Anal and oral cell samples from 20 HIV-infe
- Advising patients with genital warts--a consensus approach.
- Int J STD AIDS. 1999 Sep;10(9):619-22. Unique Identifier : AIDSLINE MED/99420180
- McOwan AG; Broughton C; Robinson AJ; Mortimer Market Centre, Mortimer Market, London, UK.
- This article reviews the evidence available to guide practitioners when advising patients with genital warts, by seeking to answer the questions most commonly asked in medical practice. It highlights where evidence is lacking and is intended to inform patients about their condition, and to identify areas where further
- Can basal cell carcinoma develop on the site of a healed gumma?
- Int J STD AIDS. 1999 Sep;10(9):623-5. Unique Identifier : AIDSLINE MED/99420181
- Narouz N; Wade AA; Allan PS; Department of Genitourinary Medicine, Conventry and Warwickshire; Hospital, UK.
- Analysis of the scientific literature on male circumcision and risk for HIV infection [letter; comment]
- Int J STD AIDS. 1999 Sep;10(9):626-8. Unique Identifier : AIDSLINE MED/99420183
- Moses S; Nagelkerke NJ; Blanchard J
- [Nutrition in AIDS]
- Nutr Hosp. 1999 May;14 Suppl 2:53S-61S. Unique Identifier : AIDSLINE MED/20015750
- Alvarez Hernandez J; Seccion de Endocrinologia y Nutricion, Hospital Universitario; Principe de Asturias, Espana.
- The infection by HIV continues to be the most aggressive pandemic of our century, with a high economical, social, and health care cost. In the last years the development of new, highly effective therapies has made it possible to change the prognosis, the quality of life, and the survival of many patients. However, the
- Further evidence that routinely reported sexually transmitted diseases presage the evolution of the AIDS epidemic [letter]
- Epidemiology. 1999 Nov;10(6):788-9. Unique Identifier : AIDSLINE MED/20004462
- Dafni U; Petridou E; Trichopoulos D; Freeman J
- [Preventive behaviors for the sexual transmission of AIDS, other infections, and pregnancy in high-school students]
- Aten Primaria. 1999 Sep 15;24(4):194-202. Unique Identifier : AIDSLINE MED/20015632
- Juarez O; Diez E; Barniol J; Villamarin F; Nebot M; Villalbi JR; Centre d'Estudis per a la Prevencio de la Sida, Universidad; Autonoma de Barcelona.
- OBJECTIVES: To describe preventive behaviors and behavioral intentions related to AIDS sexual transmission, other sexually transmitted diseases and unwanted pregnancies among 10th grade Barcelona students. DESIGN: Cross-sectional study. Stratified random sample from Barcelona secondary schools in 1996. SETTING: Second
- Serological markers of autoimmunity in patients with hemophilia A: the role of hepatitis C virus infection, alpha-interferon and factor VIII treatment in skewing the immune system toward autoreactivity.
- Blood Coagul Fibrinolysis. 1999 Sep;10(6):393-7. Unique Identifier : AIDSLINE MED/99420965
- Vianello F; Tison T; Tagariello G; Zerbinati P; Zanon E; Scarano L; Girolami A; Department of Medical and Surgical Sciences, Padua University; Medical School, Italy. faviane@tin.it
- The aim of this study was to investigate whether the immune system of patients with hemophilia A is skewed toward an aspecific activation and to identify the causative factors. It is well known that an immune derangement does exist in patients with hemophilia A. At least three factors potentially play a role: hepatiti
- Prevention of mother-to-child transmission of HIV-1.
- Curr Opin Obstet Gynecol. 1999 Oct;11(5):427-34. Unique Identifier : AIDSLINE MED/99454041
- Stringer JS; Vermund SH; School of Medicine and Public Health, University of Alabama at; Birmingham, 35294-2170, USA.
- Several recently published randomized trials have demonstrated that a substantial proportion of the mother-to-child transmission of HIV-1 can be prevented by antiretroviral therapy late in gestation and at delivery to mother and infant. The cost implications of these findings are considerable for resource-poor setting
- Recurrent pregnancy loss: an update.
- Curr Opin Obstet Gynecol. 1999 Oct;11(5):435-9. Unique Identifier : AIDSLINE MED/99454042
- Kutteh WH; Department of Obstetrics and Gynecology, The University of; Tennessee, Memphis 38163-2116, USA. wkutteh@utmem.1.utmem.edu
- This review highlights recent studies that investigate causes and treatments for recurrent pregnancy loss. Generally the causes of recurrent pregnancy loss are classified as genetic, endocrinologic, anatomic, immunologic, microbiologic, and environmental. The majority of recent work has focused on potential autoimmune
- Flow cytometric detection of type 1 (IL-2, IFN-gamma) and type 2 (IL-4, IL-5) cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid arthritis, allergic asthma and atopic dermatitis.
- Cytokine. 1999 Oct;11(10):783-8. Unique Identifier : AIDSLINE MED/99457417
- Schuerwegh AJ; De Clerck LS; De Schutter L; Bridts CH; Verbruggen A; Stevens WJ; Department of Immunology, Allergology and Rheumatology,; University of Antwerp, UIA, Antwerp, Belgium.
- Type 1 cytokines (a.o. IL-2 and IFN-gamma) play an important role in the pathogenesis of rheumatoid arthritis. On the other hand, IgE-mediated diseases such as allergic asthma and atopic dermatitis show a type 2 cytokine (amongst others IL-4 and IL-5) profile.This stud
- Peripheral nerve binding patterns of anti-sulphatide antibodies in HIV-infected individuals.
- Neuroreport. 1999 Jun 3;10(8):1659-64. Unique Identifier : AIDSLINE MED/99429661
- Petratos S; Turnbull VJ; Papadopoulos R; Ayers M; Gonzales MF; Department of Anatomical Pathology, Royal Melbourne Hospital,; Parkville, Australia.
- HIV-positive plasma samples from patients with and without neuropathy and with high titre anti-GalS antibodies showed strong binding to the myelin membrane of both fixed and unfixed human sciatic nerve specimens. This staining pattern was also seen with a plasma sample from a patient with IgM paraproteinaemic inflamma
- Cytotoxic large T-cell lymphoma with fulminant clinical course, CD8+ and CD56- phenotype, and its relation to Epstein-Barr virus: a report of two cases.
- Int J Hematol. 1999 Aug;70(2):105-11. Unique Identifier : AIDSLINE MED/99427499
- Kagami Y; Sobue R; Ito N; Yatabe Y; Taji H; Suzuki R; Seto M; Ogura M; Suchi T; Morishima Y; Nakamura S; Department of Hematology and Chemotherapy, Aichi Cancer Center; Hospital, Nagoya, Japan.
- Currently, the immunohistochemical evaluation of cytotoxic granule-associated proteins such as TIA-1 and granzyme B can be carried out on paraffin sections. This procedure has broadened our knowledge of cytotoxic lymphoid neoplasms. Their detection is now regarded as a useful adjunctive in some characterizations of cy
- Nursing texts fall short in teaching end-of-life care: even basics of pain control are poorly covered [news]
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):102-3. Unique Identifier : AIDSLINE MED/99420668
- Katz M; Ferrell BR
- $90.2 million projected budget shortfall looms for AIDS Drug Assistance Programs [news]
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):103-4. Unique Identifier : AIDSLINE MED/99420669
- Balance: have we learned the lesson? [editorial]
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):19-20. Unique Identifier : AIDSLINE MED/99420660
- Sowell RL
- The lived experience of AIDS-related multiple losses by HIV-negative gay men.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):22-31. Unique Identifier : AIDSLINE MED/99420661
- Mallinson RK
- The gay male communities of the United States have experienced the most AIDS-related deaths over the longest period of time. The burden of grief for these men is unique and largely unaddressed in nursing research and practice. This phenomenological study explored the lived experiences
- A review of fatigue in people with HIV infection.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):42-9. Unique Identifier : AIDSLINE MED/99420662
- Barroso J; University of North Carolina at Chapel Hill, School of Nursing,; USA.
- Fatigue is often cited by clinicians as a debilitating symptom suffered by the many who are infected with HIV. This article provides a review of HIV-related fatigue, including research on possible physiological causes such as anemia, CD4 count, impaired liver function, impaired thyroid function, and cortisol abnormali
- The experience of pain in persons with HIV/AIDS.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):59-67. Unique Identifier : AIDSLINE MED/99420663
- Laschinger SJ; Fothergill-Bourbonnais F
- A phenomenological design was used to elicit data about the experience of pain caused by HIV from 21 men and 1 women who attended ambulatory clinics. Data were generated through open-ended interviews. The phenomenon of pain appeared to be interpreted by the participants in a broad manner. The four themes that emerged
- HIV/AIDS, nurses, and the black church: a case study.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):71-9. Unique Identifier : AIDSLINE MED/99420664
- Baker S; Division of Nursing, New York University, USA.
- Historically, the Black church has participated by lending support, providing care, and being actively involved in the health and social welfare of its members. However, since the epidemic impact of HIV/AIDS in the Black community, the church has been sharply criticized for its lukewarm response and involvement. Nurse
- Reproductive issues in HIV-seropositive women: a survey regarding counseling, contraception, safer sex, and pregnancy choices.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):84-92. Unique Identifier : AIDSLINE MED/99420665
- Duggan J; Walerius H; Purohit A; Khuder S; Bowles M; Carter S; Kosy M; Locher A; O'Neil K; Gray A; Chakraborty J; Medical College of Ohio, Toledo, USA.
- Sixty-nine HIV-seropositive women were surveyed with regard to the reproductive counseling they had received, contraception, safer sex practices, pregnancy histories, and pregnancy plans. Of the women surveyed, 84% and 90%, respectively, felt that they had access to the birth control and safer sex methods of their cho
- Physiological and pharmacological factors of insomnia in HIV disease.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):93-7. Unique Identifier : AIDSLINE MED/99420666
- Phillips KD
- The unexpected challenges of clinical research, or what they do not tell you in school.
- J Assoc Nurses AIDS Care. 1999 Sep-Oct;10(5):98-101. Unique Identifier : AIDSLINE MED/99420667
- Dykeman M; Despotes J
- Nurse clinicians are being asked more and more frequently to be involved in nursing research. After all, who better to conduct clinical research than those people who spend much of their working day dealing with direct patient care issues. Although more nurses are beginning to understand the value of research in their
- [Differences in the structure of STLV-1 genome in Papio who died of malignant lymphoma during various chronological periods of long disease outbreak]
- Biull Eksp Biol Med. 1999 Jul;128(7):85-9. Unique Identifier : AIDSLINE MED/99414717
- Lapin BA; Chikobava MG; Iakovleva LA; Medvedeva NM
- A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients.
- Blood. 1999 Oct 1;94(7):2192-9. Unique Identifier : AIDSLINE MED/99428301
- Martin PJ; Rowley SD; Anasetti C; Chauncey TR; Gooley T; Petersdorf EW; van Burik JA; Flowers ME; Storb R; Appelbaum FR; Hansen JA; Division of Clinical Research, Fred Hutchinson Cancer Research; Center Department of Medicine, Seattle, WA, USA.; pmartin@fhcrc.org
- We conducted a phase I-II clinical trial to test the hypothesis that removal of CD4 cells from an HLA-mismatched unrelated marrow graft would substantially reduce the risk of grades III-IV graft-versus-host disease (GVHD) and that retention of a specified number of CD8 cells in the graft would be sufficient to prevent
- Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells.
- Blood. 1999 Oct 15;94(8):2809-18. Unique Identifier : AIDSLINE MED/99445390
- Verhasselt B; Naessens E; Verhofstede C; De Smedt M; Schollen S; Kerre T; Vanhecke D; Plum J; Department of Clinical Chemistry, Microbiology and Immunology,; University of Ghent, University Hospital of Ghent, Ghent,; Belgium. Bruno.Verhasselt@rug.ac.be
- Human immunodeficiency virus (HIV)-infected individuals develop an acquired immune deficiency syndrome (AIDS) due to loss in their lymphocyte numbers and cellular defects in T cells and antigen-presenting cells (APC). HIV infection of the thymus results in deficient replenishment of the peripheral naive T-cell pool. T
- Expression of human inducible nitric oxide synthase gene in T-cell lines infected with human T-cell leukemia virus type-I and primary adult T-cell leukemia cells.
- Blood. 1999 Oct 15;94(8):2862-70. Unique Identifier : AIDSLINE MED/99445396
- Mori N; Nunokawa Y; Yamada Y; Ikeda S; Tomonaga M; Yamamoto N; Department of Preventive Medicine and AIDS Research, Institute of; Tropical Medicine, Nagasaki University, Nagasaki, Japan.; n-mori@net.nagasaki-u.ac.jp
- We examined the expression of messenger RNA (mRNA) of the human inducible nitric oxide synthase (hiNOS) gene in a panel of human T-cell lines. Reverse transcriptase-polymerase chain reaction showed that human T-cell leukemia virus type-I (HTLV-I)-infected T-cell lines (MT-1, SLB-1, and C5/MJ) expressed mRNA for the hi
- Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells.
- Blood. 1999 Oct 15;94(8):2871-9. Unique Identifier : AIDSLINE MED/99445397
- Jones KD; Aoki Y; Chang Y; Moore PS; Yarchoan R; Tosato G; Division of Hematologic Products, Center for Biologics Evaluation; and Research, Food and Drug Administration, Bethesda, MD 20892,; USA.
- Primary effusion lymphoma (PEL) is a distinct type of lymphoma associated with Kaposi s sarcoma-associated herpesvirus (KSHV) infection. To determine the factors responsible for the unrestrained proliferation of PEL, we have studied the growth factor requirements of the PEL-derived BCBL-1 and BC-1 cell lines. Both cel
- Expression of cell-homologous genes of human herpesvirus-8 in human immunodeficiency virus-negative lymphoproliferative diseases.
- Blood. 1999 Oct 15;94(8):2931-3. Unique Identifier : AIDSLINE MED/99445405
- Luppi M; Barozzi P; Maiorana A; Trovato R; Marasca R; Morselli M; Cagossi K; Torelli G; Department of Medical Sciences, Section of Hematology, Modena,; Italy.
- Human herpesvirus-8 (HHV-8) genome encodes for genes homologous to human cellular genes such as interleukin-6 (IL-6), Cyclin-D, BCL-2, and IL-8 receptor (G-protein-coupled receptor [GCR]). We used reverse transcriptase-polymerase chain reaction to study the expression of these viral genes in lymphoproliferative disord
- [Knowledge about AIDS and risk behaviors among hill tribes in northern Thailand]
- Nippon Koshu Eisei Zasshi. 1999 Jun;46(6):466-75. Unique Identifier : AIDSLINE MED/99442580
- Omori K; Department of Health Sciences, School of Medicine, Kanazawa; University.
- Two hundred eighty-one Hmong, 240 Mien, and 210 Lahu hill tribe people (ages between 17-39) in northern Thailand were interviewed from March to May 1996 about their knowledge, beliefs, attitudes regarding AIDS, STDs and condoms, and sexual behavior, to guide future tribal AIDS ed
- Analysis of ritonavir in plasma/serum and tissues by high-performance liquid chromatography.
- J Pharmacol Toxicol Methods. 1998 Nov;40(4):235-9. Unique Identifier : AIDSLINE MED/99392828
- Granda BW; Giancarlo GM; von Moltke LL; Greenblatt DJ; Department of Pharmacology and Experimental Therapeutics, Tufts; University School of Medicine, New England Medical Center; Hospital, Boston, Massachusetts 02111, USA.
- A method has been developed to quantify ritonavir concentrations in human plasma and in mouse serum, liver, and brain using high-performance liquid chromatography. Extraction recoveries for ritonavir and its internal standard averaged greater than 95%
- Role of lamivudine in the treatment of chronic hepatitis B virus infection.
- Ann Pharmacother. 1999 Oct;33(10):1104-12. Unique Identifier : AIDSLINE MED/20001790
- Hagmeyer KO; Pan YY; College of Pharmacy, University of Toledo, OH 43606, USA.; Khagmey@uoft02.toledo.edu
- OBJECTIVE: To examine the evidence regarding the therapeutic effectiveness of lamivudine in the treatment of chronic hepatitis B virus (HBV) infection in immunocompetent patients. DATA SOURCES: Using chronic hepatitis B and lamivudine as MeSH headings, MEDLINE was searched from 1966 to September 1998 for all published
- The use of valproic acid in HIV-positive patients.
- Ann Pharmacother. 1999 Oct;33(10):1113-6. Unique Identifier : AIDSLINE MED/20001791
- Jennings HR; Romanelli F; University of Kentucky Medical Center, Lexington 40536, USA.; hrjenn0@pop.uky.edu
- OBJECTIVE: To review the use of valproic acid in HIV-positive patients. DATA SOURCES: Clinical literature was accessed through a MEDLINE search (January 1966-November 1998). Key search terms included HIV, AIDS, seizures, valproic acid, and glutathione. DATA SYNTHESIS: Patients with HIV often develop neurologic manifes
- An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile.
- Clin Transplant. 1999 Oct;13(5):365-74. Unique Identifier : AIDSLINE MED/99443239
- Almawi WY; Melemedjian OK; Rieder MJ; Department of Laboratory Medicine, St Georges-Orthodox Hospital,; Beirut, Lebanon.
- Glucocorticoids (GCs) are used as immunosuppressive and anti-inflammatory agents in organ transplantation and in treating autoimmune diseases and inflammatory disorders and they exert their effects by several mechanisms, the most significant of which is inhibition of cytokine production and action. Recent reports sugg
- Differences in Type 1 and Type 2 intracytoplasmic cytokines, detected by flow cytometry, according to immunosuppression (cyclosporine A vs. tacrolimus) in stable renal allograft recipients.
- Clin Transplant. 1999 Oct;13(5):400-9. Unique Identifier : AIDSLINE MED/99443244
- Rostaing L; Puyoo O; Tkaczuk J; Peres C; Rouzaud A; Cisterne JM; de Preval C; Ohayon E; Durand D; Abbal M; Multi-Organ Transplant Unit, Toulouse University Hospital,; France.
- Recent multicenter, randomized clinical trials have shown that in renal transplant patients tacrolimus (FK506) was more efficient than cyclosporine A (CsA) at preventing acute rejection. In order to try and evaluate whether this difference was related to a different in vivo T-cell suppression we assessed, in a prospec
- Does an increase in sulcal or ventricular fluid predict where brain tissue is lost?
- J Neuroimaging. 1999 Oct;9(4):201-9. Unique Identifier : AIDSLINE MED/20008104
- Symonds LL; Archibald SL; Grant I; Zisook S; Jernigan TL; Department of Psychiatry, Michigan-State University, East Lansing; 48824-1316, USA.
- Quantitative volumes of cerebrospinal fluid (CSF) and brain tissue were measured on magnetic resonance images (MRIs) of 287 individuals from 5 diagnostic groups: Alzheimer s disease (AD), chronic alcoholics (ALC), individuals positive for human immunodeficiency virus (HIV), schizophrenia subjects (SZ), and normal comp
- In vitro anti-human immunodeficiency virus activity of polysaccharide from Rhizophora mucronata Poir.
- Biosci Biotechnol Biochem. 1999 Jul;63(7):1187-91. Unique Identifier : AIDSLINE MED/99407884
- Premanathan M; Kathiresan K; Yamamoto N; Nakashima H; Department of Microbiology and Immunology, Kagoshima University; Dental School, Japan.
- A polysaccharide was extracted with 1% sodium carbonate from the bark of Rhizophora mucronata and its antiviral activities against human immunodeficiency virus (HIV) were assessed by an in vitro cell culture system. The anti-HIV activity of the alkaline extract was mainly recovered in the 25-75% ethanol-precipitated f
- CD30-positive anaplastic large cell lymphoma with HTLV-I proviral integration: a unique histologic subgroup of adult T-cell leukemia/lymphoma [editorial; comment]
- Intern Med. 1999 Oct;38(10):757-8. Unique Identifier : AIDSLINE MED/99454060
- Takeshita M
- Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma.
- Intern Med. 1999 Oct;38(10):820-3. Unique Identifier : AIDSLINE MED/99454072
- Matsushima T; Yamamoto M; Sakai K; Department of Internal Medicine, National Kyushu Medical Center; Hospital, Fukuoka.
- A 67-year-old woman with severe pain in the peripheral extremities was admitted to our hospital. Radiography of the peripheral extremities revealed multiple osteolytic lesions. Antibody to human T cell leukemia virus type-I (HTLV-I) was positive, and right radial bone biopsy showed infiltration of adult T cell leukemi
- Adult T-cell leukemia/lymphoma in which the pathohistological diagnosis was identical to that of Ki-1 positive anaplastic large cell lymphoma.
- Intern Med. 1999 Oct;38(10):824-8. Unique Identifier : AIDSLINE MED/99454073
- Takahara T; Masutani K; Kajiwara E; Sadoshima S; Misago M; Sasaguri Y; Onoyama K; Division of Internal Medicine, Nippon Steel Yawata Memorial; Hospital, Kitakyushu.
- A 65-year-old man developed severe lumbago and a loss of appetite two months before presentation. A computerized tomograph at admission revealed soft tissue masses destroying the Th12, L4 and L5 vertebral bones. We diagnosed the lesions to be metastatic bone tumors, but the primary focus could not be determined. Just
- Comparison of methods for assessing nutritional status in HIV-infected adults.
- Nutrition. 1999 Oct;15(10):740-3. Unique Identifier : AIDSLINE MED/99429393
- Niyongabo T; Melchior JC; Henzel D; Bouchaud O; Larouze B; Departement de Medecine Interne, CHU de Bujumbura, Burundi.
- Malnutrition is a frequent complication of human immunodeficiency virus (HIV) infection and is associated with a poor prognosis. To compare different measures of nutritional status in HIV-infected patients, we prospectively studied 88 outpatients seen at a Paris AIDS outpatient clinic for routine follow-up examination
- Effect of protease inhibitors on the sense of taste.
- Nutrition. 1999 Oct;15(10):767-72. Unique Identifier : AIDSLINE MED/99429398
- Schiffman SS; Zervakis J; Heffron S; Heald AE; Department of Psychiatry, Duke University Medical Center, Durham,; North Carolina 27710, USA. sss@acpub.duke.edu
- The purpose of this study was to investigate the taste properties of protease inhibitors which are essential components of drug regimes used to treat human immunodeficiency virus (HIV) infection. In this study, the taste properties of four protease inhibitors (
- Antiretroviral therapy for pediatric and adolescent HIV.
- J Sch Nurs. 1998 Apr;14(2):36-46. Unique Identifier : AIDSLINE MED/98274506
- Terriff CM; Synoground G; Washington State University College of Pharmacy, Deaconess; Medical Center, Spokane, USA.
- As the number of children infected in the HIV epidemic increases, the school nurse can play an important role in ensuring that these children receive comprehensive health care. Compliance with following an immunization program for HIV-infected children is a potential problem for various reasons. Many of these children
- IL-4 induces eotaxin in human dermal fibroblasts.
- Int Arch Allergy Immunol. 1999;120 Suppl 1:19-23. Unique Identifier : AIDSLINE MED/20002192
- Mochizuki M; Schroder J; Christophers E; Yamamoto S; Department of Dermatology, Hiroshima University School of; Medicine, Hiroshima, Japan. mitzuru@ipc.hiroshima-u.ac.jp
- A common feature of Th2-mediated skin diseases is selective eosinophil (Eo) infiltration in the affected dermis. However, the mechanisms of selective Eo recruitment are not yet fully understood. Our recent findings indicated that dermal fibroblasts actively participate in the accumulation of Eo in Th2-mediated skin in
- Diagnosing and treating asymptomatic tuberculosis infection.
- Can Fam Physician. 1999 Oct;45:2397-404. Unique Identifier : AIDSLINE MED/20008213
- Wang CT; Department of Family and Community Medicine, St Michael's; Hospital, Toronto, Ont.
- OBJECTIVE: To summarize relevant parts of the guidelines recommended by the Canadian and American Thoracic Societies for diagnosis and management of asymptomatic tuberculosis (TB) infection. QUALITY OF EVIDENCE: The latest guidelines published by the Canadian and American Thoracic Societies were reviewed. Unfortunatel
- Pulmonary cryptococcosis: manifestations in the era of acquired immunodeficiency syndrome.
- J Formos Med Assoc. 1999 Sep;98(9):621-6. Unique Identifier : AIDSLINE MED/20024028
- Wu TT; Wang HC; Yang PC; Kuo SH; Luh KT; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, Taiwan.
- To examine the clinical manifestations, treatment, and outcome of pulmonary cryptococcosis, we reviewed the medical records of all patients treated for Cryptococcus neoformans infection at our hospital from January 1988 through September 1998. Sixty-three patients were included in the analysis, 10 (16%) of whom had ac
- Failure of screening to detect HIV in a foreign laborer who died of toxoplasmosis of the central nervous system.
- J Formos Med Assoc. 1999 Sep;98(9):639-42. Unique Identifier : AIDSLINE MED/20024031
- Juan CW; Wu FF; Chang WH; Chou CC; Lee TC; Lin JC; Department of Medicine, Wellington School of Medicine, University; of Otago, New Zealand.
- The most common neurologic complication in patients with acquired immunodeficiency syndrome (AIDS) is cerebral toxoplasmosis. Patients with cerebral toxoplasmosis have characteristic findings on clinical examination and neuroimaging. They require prolonged treatment and have a considerable mortality rate. We report a
- AIDS-related lymphoma.
- Blood Rev. 1999 Sep;13(3):147-50. Unique Identifier : AIDSLINE MED/99454390
- Tulpule A; Levine A; Department of Hematology, Norris Cancer Center, USC School of; Medicine, Los Angeles, CA 90033, USA. tulpule@hsc.usc.edu
- The incidence of intermediate and high grade B-cell non-Hodgkin s lymphomas in HIV-infected individuals is approximately 60 times greater than in the general population. These AIDS-related lymphomas (AIDS-NHL) are a late manifestation of HIV infection and may increase in frequency as patients live longer with highly a
- Dermatologic complications in HIV.
- Nurse Pract Forum. 1999 Jun;10(2):87-94. Unique Identifier : AIDSLINE MED/20010298
- Ellis P; Johnson DP; Infectious Disease Section, Bay Pines VAMC, FL 33744, USA.
- The skin is unique in its accessibility for the diagnosis of diseases acquired because of decreased immunity in human immunodeficiency virus (HIV) infection. A majority of HIV-infected patients will have dermatologic problems at some time during their illness. Many of the cutaneous conditions identified will provide t
- Baby to be tested for HIV against parents' wishes [news]
- BMJ. 1999 Sep 11;319(7211):658. Unique Identifier : AIDSLINE MED/99410279
- Dyer C
- Encouraging HIV positive people to participate in clinical trials [letter]
- BMJ. 1999 Sep 18;319(7212):787-8. Unique Identifier : AIDSLINE MED/99418942
- Williams JH
- AIDS cuts life expectancy insub-saharan Africa by a quarter [news]
- BMJ. 1999 Sep 25;319(7213):806. Unique Identifier : AIDSLINE MED/99426737
- Logie D
- Routine antenatal HIV testing. Is justified in areas of low HIV prevalence [letter]
- BMJ. 1999 Oct 16;319(7216):1069. Unique Identifier : AIDSLINE MED/99451017
- Foley E; Harindra V
- Routine antenatal HIV testing. Is acceptable to women [letter]
- BMJ. 1999 Oct 16;319(7216):1069-70. Unique Identifier : AIDSLINE MED/20037536
- Blott M; Yearwood J; Gerval M; Welch J; Zuckerman M
- Economic cost of alcohol and drug abuse in the United States, 1992: a report [see comments]
- Addiction. 1999 May;94(5):631-5. Unique Identifier : AIDSLINE MED/20028765
- Harwood HJ; Fountain D; Fountain G; Lewin Group, Fairfax, VA 22031, USA.
- Economic costs calculations and drug policy evaluation [comment]
- Addiction. 1999 May;94(5):641-4. Unique Identifier : AIDSLINE MED/20028768
- Kopp P; Paris XII-University, France.
- Adult T cell leukemia lymphoma (ATL) localized in the right tibial bone.
- Leuk Lymphoma. 1999 Sep;35(1-2):189-92. Unique Identifier : AIDSLINE MED/99440727
- Tabata M; Takahashi H; Izumi T; Komatsu N; Tsunoda J; Yoshida M; Nakama S; Kuriki K; Saito K; Hatake K; Miura Y; Department of Medicine, Jichi Medical School; Minami-kawachi-Machi, Tochigi-Ken, Japan.
- A 56-year-old man was admitted complaining of pain in the right tibia. He was diagnosed as having adult T-cell leukemia/lymphoma (ATL/L) in the right knee joint by roentgenographic and histological examination. Monoclonal integration of HTLV-I proviral DNA was demonstrated in the bone tumor cells, although polyclonal
- Apoptosis.
- Stem Cells. 1999;17(5):306-13. Unique Identifier : AIDSLINE MED/99454589
- Israels LG; Israels ED; University of Manitoba, Manitoba Cancer Treatment and Research; Foundation, Canada.
- Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form. The interactive CD, in particular, brings m
- Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension.
- Clin Exp Hypertens. 1999 Oct;21(7):1177-88. Unique Identifier : AIDSLINE MED/99441993
- Kagawa H; Nomura S; Ozaki Y; Nagahama M; Fukuhara S; The First Department of Internal Medicine, Kansai Medical; University, Moriguchi, Osaka, Japan.
- We examined some immunological parameters, particularly cytokines and soluble factors in collagen diseases complicated with essential hypertension. We also investigated the effects of Nilvadipine on immunological parameters after treatment with this drug for six months. The frequency of helper/inducer T cells (CD4+ CD
- Economic methods for measuring the quality of life associated with HIV infection.
- Qual Life Res. 1999 Sep;8(6):471-80. Unique Identifier : AIDSLINE MED/20016578
- Bayoumi AM; Redelmeier DA; Department of Medicine, University of Toronto, Canada.; ahmed.bayoumi@utoronto.ca
- BACKGROUND: Quality of life is measured as utilities for cost-effectiveness analyses. OBJECTIVE: To test the adequacy of three common utility elicitation methods for individuals with Human Immunodeficiency Virus (HIV) disease. MEASUREMENTS: HIV-positive participants (n = 75) rated three standardized health states (sym
- Two approaches to measuring quality of life in the HIV/AIDS population: HAT-QoL and MOS-HIV.
- Qual Life Res. 1999 Sep;8(6):515-27. Unique Identifier : AIDSLINE MED/20016583
- Holmes WC; Shea JA; Division of General Internal Medicine, Leonard Davis Institute of; Health Economics, University of Pennsylvania, Philadelphia; 19104-2676, USA. holmeswc@mail.med.upenn.edu
- OBJECTIVES: Reduce the number of HIV/AIDS-Targeted Quality of Life (HAT-QoL) items, assess psychometric performance of the shortened HAT-QoL, and compare psychometric performance of HAT-QoL to that of Medical Outcomes study HIV Health Survey (MOS-HIV). DESIGN/SUBJECTS: Convenience sample of 215 cross-sectionally studi
- The threat of multidrug-resistant tuberculosis: results of 1 yr of surveillance in the Lombardy region of Italy.
- Monaldi Arch Chest Dis. 1999 Aug;54(4):332-6. Unique Identifier : AIDSLINE MED/20013800
- Salamina G; Sodano L; Mezzetti F; Moro ML; Osservatorio Epidemiologico Dipendenze, USL 5 Grugliasco, Turin,; Italy.
- A descriptive multicentre study based on laboratory data was carried out in patients with culture-confirmed tuberculosis (TB) who were cared for between September 1995 and August 1996 in 14 general hospitals with at least one human immunodeficiency virus (HIV) ward, a hospital specializing in TB or a large chest clini
- [Human herpes virus 8 and Kaposi's sarcoma]
- Rev Assoc Med Bras. 1999 Jan-Mar;45(1):55-62. Unique Identifier : AIDSLINE MED/99365648
- Leao JC; Hinrichsen SL; de Freitas BL; Porter SR; Departamento de Medicina Oral, Eastman Dental Institute,; Universidade de Londres.
- [Lymphoma/leukemia of T cells in adults]
- Rev Assoc Med Bras. 1999 Jan-Mar;45(1):63-70. Unique Identifier : AIDSLINE MED/99365649
- Borducchi DM; Kerbauy J; de Oliveira JS; Universidade Federal de Sao Paulo, Escola Paulista de Medicina.
- [The HIV-positive health care worker: lessons for biosafety and ethics]
- Rev Assoc Med Bras. 1999 Apr-Jun;45(2):163-8. Unique Identifier : AIDSLINE MED/99342326
- Campos MA; Hospital das Clinicas da Universidade Federal de Minas Gerais,; Belo Horizonte.
- After the contamination with HIV of 6 patients by an american dentist, great concern about the work of HIV-positive health care workers emerged. In spite of the good effects of preventive programs (also including other viruses more contagious than HIV, like the hepatitis virus), that concern is still confuse and misun
- AIDS and HIV infection in the United Kingdom: monthly report.
- Commun Dis Rep CDR Wkly. 1999 Oct 29;9(44):395-8. Unique Identifier : AIDSLINE MED/20023965
- An Escherichia coli-based genetic strategy for characterizing RNA binding proteins.
- Methods Mol Biol. 1999;118:161-75. Unique Identifier : AIDSLINE MED/20017288
- Jain C; Skirball Institute of Biomolecular Medicine, New York University; Medical Center, New York, USA.
- Screening RNA-binding libraries using a bacterial transcription antitermination assay.
- Methods Mol Biol. 1999;118:177-87. Unique Identifier : AIDSLINE MED/20017289
- Harada K; Frankel AD; Department of Life Sciences, Tokyo Gakugei University, Japan.
- [Secrecy in children with HIV infection]
- Arch Pediatr. 1999 Oct;6(10):1101-8. Unique Identifier : AIDSLINE MED/20012031
- Champion M; Lefebvre Des Noettes A; Taboulet P; Lemerle S; Service de psychiatrie, hopital Saint-Antoine, Paris, France.
- The secrecy surrounding the disease of parents and children infected with HIV leads to psychic and affective isolation and difficulties of communication within the family. Psychological management may possibly help to resolve the problem of secrecy between parents and children. We analyzed the organization and dynamic
- [Agranulocytosis and transitory immune deficiency after fetal exposure to azathioprine and mesalazine (letter)]
- Arch Pediatr. 1999 Oct;6(10):1136-7. Unique Identifier : AIDSLINE MED/20012043
- Cissoko H; Jonville-Bera AP; Lenain H; Riviere MF; Saugier J; Casanova JL; Autret-Leca E
- The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection [see comments]
- J Gastroenterol. 1999 Oct;34(5):560-70. Unique Identifier : AIDSLINE MED/20004140
- Itoh T; Wakatsuki Y; Yoshida M; Usui T; Matsunaga Y; Kaneko S; Chiba T; Kita T; Department of Clinical Bio-regulatory Science, Kyoto University; Graduate School of Medicine, Japan.
- Helicobacter pylori infection is associated with chronic infiltration by various cell types, including T cells, whose cytokine production may regulate the inflammatory reaction as well as local immune response to the bacterium. We prospectively analyzed the constituents of the cellular infiltrates and the cytokines pr
- Clinical and virological features of chronic hepatitis C carriers with normal alanine aminotransferase levels despite positive serum HCV-RNA after interferon therapy [see comments]
- J Gastroenterol. 1999 Oct;34(5):594-9. Unique Identifier : AIDSLINE MED/20004145
- Arase Y; Ikeda K; Chayama K; Murashima N; Tsubota A; Nakamura I; Suzuki Y; Saitoh S; Kobayashi M; Kobayashi M; Kobayashi M; Kumada H; Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
- Interferon (IFN) is the only drug that induces viral clearance, but in patients with chronic hepatitis C, HCV-RNA clearance is achieved in only 20%-40% of patients treated with IFN for 6 months. The remaining patients have positive serum HCV-RNA, but about 5%-15% of the patients with positive serum HCV-RNA after IFN t
- Overshift towards T helper (Th)1 cells induces gastric mucosal injury: immunopathology of Helicobacter pylori-infected gastric mucosa [editorial; comment]
- J Gastroenterol. 1999 Oct;34(5):651-2. Unique Identifier : AIDSLINE MED/20004157
- Sugiyama T; Asaka M
- Oxidative DNA base damage in lymphocytes of HIV-infected drug users.
- Free Radic Res. 1999 Sep;31(3):197-200. Unique Identifier : AIDSLINE MED/99428122
- Jaruga P; Jaruga B; Olczak A; Halota W; Olinski R; Department of Clinical Biochemistry, The Ludwik Rydygier Medical; University, Bydgoszcz, Poland. pjaruga@aciamb.bydgoszcz.pl
- In the present study, we have studied the level of oxidative DNA base damage in lymphocytes of HIV-infected intravenous drug users (IDUs) and a seronegative control group. Chromatin was isolated from the lymphocytes and then analyzed by gas chromatography/isotope-dilution mass spectrometry with selected-ion monitoring
- Determination of human immunodeficiency virus-1 protease inhibitors in patient serum using free solution capillary zone electrophoresis.
- J Chromatogr A. 1999 Aug 20;853(1-2):431-7. Unique Identifier : AIDSLINE MED/99416204
- Chelyapov N; Jacobs SA; Magee TJ; Dionex Corporation, Sunnyvale, CA 94086, USA. nchelyapov@aol.com
- The goal of this study was to develop a fast, inexpensive and quantitative method for serum determination of the human immunodeficiency virus protease inhibitors Crixivan (C),
- Both CD4+ and CD8+ lymphocytes reduce the severity of tissue lesions in murine systemic cadidiasis, and CD4+ cells also demonstrate strain-specific immunopathological effects.
- Microbiology. 1999 Jul;145 ( Pt 7):1631-40. Unique Identifier : AIDSLINE MED/99368257
- Ashman RB; Fulurija A; Papadimitriou JM; School of Dentistry, University of Queensland, Brisbane,; Australia. R.Ashman@mailbox.uq.edu.au
- The role of T lymphocytes in host responses to sublethal systemic infection with Candida albicans was evaluated by mAb depletion of CD4+ and CD8+ cells from BALB/c and CBA/CaH mice, which develop mild and severe tissue damage, respectively. Depletion of CD4+ lymphocytes from BALB/c mice markedly increased tissue damag
- Nursing behind bars.
- Nurs Spectr (Wash D C). 1998 Apr 6;8(7):7. Unique Identifier : AIDSLINE MED/20010413
- Ollinger M
- Promoting medication adherence in HIV treatment.
- Nurs Spectr (Wash D C). 1999 Jan 11;9(1):12-4. Unique Identifier : AIDSLINE MED/20010508
- Dean LM; King ES; HIV/AIDS Medicine Section, MCP Hahnemann University,; Philadelphia, PA, USA.
- The Sydney Blood Bank Cohort: a case-control study using a transfused HIV-1 seronegative group.
- Ann Epidemiol. 1999 Oct;9(7):436-40. Unique Identifier : AIDSLINE MED/99429519
- McIntyre LB; Geczy AF; Dyer WB; Learmont JC; Sullivan JS; Australian Red Cross Blood Service-NSW, Sydney, New South Wales.
- PURPOSE: To compare the immunological function of the Sydney Blood Bank Cohort (SBBC), a unique group of individuals who were all infected with a similar, attenuated strain of HIV-1, with a matched HIV-1 seronegative control group. To establish whether the asymptomatic state of the SBBC, in 1996, was likely to continu
- Six-year experience with cryopreserved mitral homografts in the treatment of tricuspid valve endocarditis in HIV-infected drug addicts.
- J Heart Valve Dis. 1999 Sep;8(5):575-7. Unique Identifier : AIDSLINE MED/99444989
- Mestres CA; Miro JM; Pare JC; Pomar JL; Department of Cardiovascular Surgery, Hospital Clinic, University; of Barcelona, Spain.
- BACKGROUND AND AIM OF THE STUDY: In the past, valve homografts have been used in the treatment of aortic endocarditis. This report details our experience in tricuspid valve replacement using cryopreserved mitral homografts in HIV-positive drug addicts with infective endocarditis. METHODS: Five HIV-1-infected drug addi
- Increased expression of IL-12 receptor mRNA in active pulmonary tuberculosis and sarcoidosis.
- Am J Respir Crit Care Med. 1999 Oct;160(4):1119-23. Unique Identifier : AIDSLINE MED/99439821
- Taha RA; Minshall EM; Olivenstein R; Ihaku D; Wallaert B; Tsicopoulos A; Tonnel AB; Damia R; Menzies D; Hamid QA; Meakins-Christie Laboratories and Montreal Chest Research; Institute, McGill University, Montreal, Quebec, Canada.
- Cytokines have been implicated in the pathophysiology and development of pulmonary diseases such as tuberculosis and sarcoidosis. In particular, the numbers of cells expressing Th1-type cytokines such as IFN-gamma and IL-12 are increased within the lungs of patients with these granulomatous diseases. As a factor promo
- Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease.
- Am J Respir Crit Care Med. 1999 Oct;160(4):1263-8. Unique Identifier : AIDSLINE MED/99439842
- Aberle JH; Aberle SW; Dworzak MN; Mandl CW; Rebhandl W; Vollnhofer G; Kundi M; Popow-Kraupp T; Institute of Virology, University of Vienna, Children's Cancer; Research Institute, Vienna, Austria.
- We examined the in vivo cell-mediated immune response in infants with respiratory syncytial virus (RSV) infection in order to gain information about the pathogenesis of severe RSV disease in infancy. Semiquantitative reverse transcription-polymerase chain reaction and three-color flow cytometry were used to determine
- The diagnosis, transmission and prevention of HIV-1 in the infant under 18 months of age: implications for nursing practice.
- J Clin Nurs. 1998 Jul;7(4):297-306. Unique Identifier : AIDSLINE MED/99048662
- Purssell E; Paediatric Infectious Diseases Unit, St George's Hospital,; London, UK.
- Vertical transmission of HIV from mother-to-child is a significant problem around the world. This paper examines the main issues that confront those caring for pregnant women who may transmit HIV-1 to their babies with reference to the impact upon clinical practice. Nursing practice should accommodate research from a
- Experimental respiratory cryptosporidiosis in immunosuppressed rats: a light and electron microscopy study.
- Parasite. 1999 Sep;6(3):217-22. Unique Identifier : AIDSLINE MED/99441640
- Lanzarini P; Gatti S; Bruno A; Corona S; Scaglia M; Laboratory of Electron Microscopy, University-IRCCS San Matteo,; Pavia, Italy.
- Cryptosporidium parvum is a coccidian protozoon that causes diarrhoeal enteritis in immunocompetent and immunocompromised humans and other mammals. Sometimes, chiefly in HIV-infected subjects, anatomical sites other than gastro-intestinal tract, such as the biliary and respiratory tree, are involved. We performed an e
- Involving men in reproductive health advocacy in the United Republic of Tanzania.
- Promot Educ. 1999 Jun;6(2):20-3, 39, 50-1. Unique Identifier : AIDSLINE MED/99363186
- Popoola D; IEC Labour, UNFPA CST for East and Central Africa, Addis Ababa,; Ethiopia. popoola@unfpa.org
- The association between primary source of ambulatory care and access to and outcomes of treatment among AIDS patients.
- Int J Qual Health Care. 1999 Aug;11(4):293-300. Unique Identifier : AIDSLINE MED/99429707
- McLaughlin TJ; Soumerai SB; Weinrib D; Aupont O; Cotton D; Department of Ambulatory Care and Prevention, Harvard Medical; School and the Harvard Pilgrim Health Care, Boston, MA 02215,; USA. tom_mclaughlin@HMS.harvard.edu
- OBJECTIVES: To examine the relationship between having a primary source of ambulatory care (PSAC), access to AIDS treatment and prophylaxis for opportunistic infection, and hospital and mortality outcomes among heterosexual men and women with AIDS. METHODS: Using a linked AIDS Registry-Medicaid database, 366 adults we
- Lymphocyte subsets as prognostic markers for cancer patients receiving immunomodulative therapy.
- Med Oncol. 1999 Sep;16(3):145-53. Unique Identifier : AIDSLINE MED/99456321
- Hernberg M; Department of Internal Medicine, Helsinki University Central; Hospital, Finland. micaela.hernberg@helsinki.fi
- Immunogenic features of some malignancies have aroused interest in immunotherapy of cancer. Immunotherapy seems most effective in patients with a small tumour burden, and the focus of immunotherapy trials has, thus, lately been on adjuvant treatment. To enable further development of immunotherapy we need to know more
- Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete.
- Bioorg Med Chem. 1999 May;7(5):895-9. Unique Identifier : AIDSLINE MED/99325930
- Pettit GR; Tan R; Melody N; Kielty JM; Pettit RK; Herald DL; Tucker BE; Mallavia LP; Doubek DL; Schmidt JM; Cancer Research Institute and Department of Chemistry, Arizona; State University, Tempe 85287-2404, USA.
- A Montana soil actinomycete, Streptomyces anulatus, produced (1 x 10(-2)% yield) a new cancer cell growth inhibitory cyclooctadepsipeptide named montanastatin (1) accompanied by the potent anticancer antibiotic valinomycin (2) in very high (5.1%) yields. Valinomycin but not montanastatin inhibited growth of a number o
- Indolo[3,2-c]cinnolines with antiproliferative, antifungal, and antibacterial activity.
- Bioorg Med Chem. 1999 Aug;7(8):1591-6. Unique Identifier : AIDSLINE MED/99410177
- Barraja P; Diana P; Lauria A; Passannanti A; Almerico AM; Minnei C; Longu S; Congiu D; Musiu C; La Colla P; Istituto Farmacochimico, Universita degli Studi, Palermo, Italy.
- A series of indolo[3,2-c]cinnoline derivatives was prepared and tested to evaluate their biological activity. Most of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. With the exception of 7g
- Imidazothiadiazine dioxides: synthesis and antiviral activity.
- Bioorg Med Chem. 1999 Aug;7(8):1617-23. Unique Identifier : AIDSLINE MED/99410180
- Martinez A; Esteban AI; Herrero A; Ochoa C; Andrei G; Snoeck R; Balzarini J; De Clercq E; Instituto de Quimica Medica (CSIC), Madrid, Spain.
- A new series of imidazothiadiazine dioxides, including the first acyclonucleosides derived from this heterocycle moiety, has been synthesized. A wide-spectrum antiviral screening was performed. Some of the N-1 benzyl imidazothiadiazines and the new acyclonucleosides showed interesting anti-
- Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents.
- Bioorg Med Chem. 1999 Sep;7(9):1907-11. Unique Identifier : AIDSLINE MED/99458522
- Xia P; Yang ZY; Xia Y; Zheng YQ; Cosentino LM; Lee KH; Department of Organic Chemistry, School of Pharmacy, Shanghai; Medical University, People's Republic of China.
- In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 microM and 300, respectively.
- Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum.
- Bioorg Med Chem. 1999 Sep;7(9):2047-52. Unique Identifier : AIDSLINE MED/99458537
- Mizushina Y; Takahashi N; Hanashima L; Koshino H; Esumi Y; Uzawa J; Sugawara F; Sakaguchi K; Department of Applied Biological Science, Science University of; Tokyo, Chiba, Japan.
- Terpenoids, 1, 2 and 3, which selectively inhibit eukaryotic DNA polymerase activities, were isolated from the fruiting body of a basidiomycete, Ganoderma lucidum, and their structures were determined by spectroscopic analyses. New terpenes, lucidenic acid O (1) and lucidenic lactone (2), prevented not only the activi
- Structure-activity relationship of HIV-1 protease inhibitors containing alpha-hydroxy-beta-amino acids. Detailed study of P1 site.
- Bioorg Med Chem. 1999 Sep;7(9):2063-72. Unique Identifier : AIDSLINE MED/99458539
- Takashiro E; Hayakawa I; Nitta T; Kasuya A; Miyamoto S; Ozawa Y; Yagi R; Yamamoto I; Shibayama T; Nakagawa A; Yabe Y; Exploratory Chemistry Research Laboratory, Sankyo Co. Ltd.,; Tokyo, Japan.
- The structure-activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing alpha-hydroxy-beta-amino acids is discussed. We demonstrated that substituent groups on the P1 aromatic rings of the inhibitors exert significant influence on their biological activity. Inhibitors bearing an alkyl or a fluorine atom
- Design and synthesis of a novel series of HIV-1 protease inhibitors.
- Bioorg Med Chem. 1999 Sep;7(9):2105-14. Unique Identifier : AIDSLINE MED/99458544
- Takashiro E; Nakamura Y; Miyamoto S; Ozawa Y; Sugiyama A; Fujimoto K; Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd.,; Tokyo, Japan.
- The synthesis and the SAR study of novel pseudo symmetric inhibitors of HIV-1 protease are described. Michael addition of amino acid derivatives to vinyl ketones was utilized to derive a potent (nM) series of HIV-1 protease inhibitors .
- [The TH2 theory in allergy]
- Rev Alerg Mex. 1999 May-Jun;46(3):83-8. Unique Identifier : AIDSLINE MED/99354618
- Rojas Ramos E; Martinez Jimenez NE; Medicos Adscritos al Servicio de Alergia e Inmunologia; Clinica, Hospital Regional 1o de Octubre, ISSSTE.
- The allergic diseases are determined by genetics and thought to affect between 20 to 30 percent of general people in developed countries. The prevalence has increased in the last decade. The allergic diseases are characterised by an increase of B-lymphocytes ability to produce IgE antibody; this synthesis of human Ig
- Partial splenectomy in a child with human immunodeficiency virus-related immune thrombocytopenia.
- J Pediatr Hematol Oncol. 1999 Sep-Oct;21(5):441-3. Unique Identifier : AIDSLINE MED/99452093
- Monpoux F; Kurzenne JY; Sirvent N; Cottalorda J; Boutte P; Service de Pediatrie, Hopital de l'Archet II, Nice, France.
- Immune thrombocytopenia (IT) is a frequently occurring disease in childhood and a well known complication of HIV infection. Splenectomy is a part of the treatment strategy for severe chronic IT. However, overwhelming infections after splenectomy have limited its use, especially in young children. A 7-year-old child wi
- Cost-effectiveness of a post-exposure HIV chemoprophylaxis program for blood exposures in health care workers.
- J Occup Environ Med. 1999 Sep;41(9):754-60. Unique Identifier : AIDSLINE MED/99420651
- Marin MG; Van Lieu J; Yee A; Bonner E; Glied S; UMD-New Jersey Medical School, Newark 07103, USA.
- We performed a cost-effectiveness analysis of a post-exposure chemoprophylaxis program for health care workers who sustained exposures to blood. We analyzed a program of (1) treatment with zidovudine alone versus no treatment and (2) treatment with three-drug therapy versus no treatment. Assuming that 35% of exposures
- Increased leucine turnover and insulin resistance in men with advanced HIV infection.
- J Investig Med. 1999 Sep;47(8):405-13. Unique Identifier : AIDSLINE MED/99440288
- Hardin DS; LeBlanc A; Young D; Johnson P; Department of Pediatrics, University of Texas Health Science; Center, Houston 77030, USA.
- BACKGROUND: The purpose of this study was to determine if patients with advanced HIV infection exhibit increased rates of leucine turnover and to determine dose effects of insulin on suppression of leucine turnover. We also wished to evaluate hepatic glucose production and re-examine peripheral insulin sensitivity in
- Neutrons expand the field of structural biology.
- Curr Opin Struct Biol. 1999 Oct;9(5):602-8. Unique Identifier : AIDSLINE MED/99439925
- Niimura N; Advanced Science Research Center, Japan Atomic Energy Research; Institute, Tokai-mura, Naka-gun, Ibaraki-ken, 319-1195, Japan.; niimura@kotai3.tokai.jaeri.go.jp
- Neutron protein crystallography aids the identification of all the hydrogen atoms in biological macromolecules and has helped to establish hydration patterns in proteins. Recent technical innovations, such as the development of the neutron imaging plate, have made it possible to shorten the prohibitively long amount o
- Battling AIDS [editorial; comment]
- Nat Struct Biol. 1999 Oct;6(10):895-6. Unique Identifier : AIDSLINE MED/99436508
- Blocking HIV entry [news; comment]
- Nat Struct Biol. 1999 Oct;6(10):906-8. Unique Identifier : AIDSLINE MED/99436512
- Buzko OV; Shokat KM
- Targeting the fusogenic machinery of HIV with unnatural ligand libraries.
- Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.
- Nat Struct Biol. 1999 Oct;6(10):937-43. Unique Identifier : AIDSLINE PDB/1C2P
- Lesburg CA; Cable MB; Ferrari E; Hong Z; Mannarino AF; Weber PC; Department of Structural Chemistry, Schering-Plough Research; Institute, Kenilworth, New Jersey 07033, USA.
- Various classes of nucleotidyl polymerases with different transcriptional roles contain a conserved core structure. Less is known, however, about the distinguishing features of these enzymes, particularly those of the RNA-dependent RNA polymerase class. The 1. 9 A resolution crystal structure of hepatitis C virus (HCV
- Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements [see comments]
- Nat Struct Biol. 1999 Oct;6(10):953-60. Unique Identifier : AIDSLINE MED/99436524
- Ferrer M; Kapoor TM; Strassmaier T; Weissenhorn W; Skehel JJ; Oprian D; Schreiber SL; Wiley DC; Harrison SC; Department of Molecular and Cellular Biology, Harvard University,; 7 Divinity Ave., Cambridge, Massachusetts 02138, USA.
- The trimeric, alpha-helical coiled-coil core of the HIV-1 gp41 ectodomain is thought to be part of a transient, receptor-triggered intermediate in the refolding of the envelope glycoprotein into a fusion-active conformation. In an effort to discover small organic inhibitors that block gp41 activation, we have generate
- Hematologic abnormalities among HIV-infected patients: associations of significance for dentistry.
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Nov;88(5):561-7. Unique Identifier : AIDSLINE MED/20027789
- Patton LL; University of North Carolina at Chapel Hill, Department of Dental; Ecology, NC 27599-7450, USA.
- OBJECTIVE: The purpose of this study was to determine the prevalence and severity of and the factors associated with peripheral blood cytopenias among HIV-infected patients. STUDY DESIGN: The investigation involved 516 HIV-infected adults in a longitudinal study of oral disease. Prevalence of hemoglobin, hematocrit, w
- Oral Candida dubliniensis as a clinically important species in HIV-seropositive patients in the United States.
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Nov;88(5):573-80. Unique Identifier : AIDSLINE MED/20027791
- Meiller TF; Jabra-Rizk MA; Baqui Aa; Kelley JI; Meeks VI; Merz WG; Falkler WA; Department of Oral Medicine and Diagnostic Sciences, Dental; School, University of Maryland, Baltimore 21201, USA.
- OBJECTIVE: Interest in Candida dubliniensis has led to renewed clinical investigations regarding incidence, drug resistance, pathogenesis, and epidemiology of fungal infections in patients with HIV. C dubliniensis phenotypically resembles Candida albicans in many respects, yet it can be identified and differentiated a
- Hydroxyurea in the treatment of human immunodeficiency virus infection.
- Unique Identifier : AIDSLINE MED/99406111
- Gelone SP; Kostman JR; School of Pharmacy, Temple University, Philadelphia, PA 19140,; USA.
- Paronychia of the great toes associated with protease inhibitors [letter]
- Am J Health Syst Pharm. 1999 Aug 15;56(16):1674-5. Unique Identifier : AIDSLINE MED/99388683
- Kang-Birken SL; Prichard JG
- Challenges of thalidomide distribution in a hospital setting.
- Am J Health Syst Pharm. 1999 Sep 1;56(17):1721-5. Unique Identifier : AIDSLINE MED/99441054
- Keravich DP; Daniels CE; Pharmacy Department, Warren G. Magnuson Clinical Center, National; Institutes of Health, Bethesda, MD 20892, USA.
- The various physician, patient, and pharmacy requirements for participation in the System for Thalidomide Education and Prescribing Safety (S.T.E.P.S.) program and procedures that institutions may implement in order to comply with these requirements are described. In 1998, FDA approve
- Proposed mechanisms of transfusion-induced immunomodulation.
- Clin Diagn Lab Immunol. 1999 Sep;6(5):652-7. Unique Identifier : AIDSLINE MED/99403259
- Kirkley SA; University of Rochester Medical Center, Rochester, New York; 14642, USA. Scott_Kirkley@urmc.rochester.edu
- Low levels of antigenic variability in fluconazole-susceptible and -resistant Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.
- Clin Diagn Lab Immunol. 1999 Sep;6(5):665-70. Unique Identifier : AIDSLINE MED/99403262
- Lopez-Ribot JL; McAtee RK; Kirkpatrick WR; La Valle R; Patterson TF; Department of Medicine, Division of Infectious Diseases, The; University of Texas Health Science Center at San Antonio, San; Antonio, Texas 78284-7881, USA. ribot@uthscsa.edu
- Three serial isolates of Candida albicans were obtained by direct swab or by oral saline rinses from each of five human immunodeficiency virus-infected patients with recurrent oropharyngeal candidiasis. Genotyping techniques confirmed the presence of a persistent strain in multiple episodes from the same patient, whic
- Detection of borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by
- Unique Identifier : AIDSLINE MED/99403268 P P
- Modulation of T-cell responses to a recall antigen in human T-cell leukemia virus type 1-infected individuals.
- Clin Diagn Lab Immunol. 1999 Sep;6(5):713-7. Unique Identifier : AIDSLINE MED/99403271
- Suzuki M; Dezzutti CS; Okayama A; Tachibana N; Tsubouchi H; Mueller N; Lal RB; Retrovirus Disease Branch, Division of AIDS, STD, and TB; Laboratory Research, National Centers for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- To determine the mechanism of the purified protein derivative (PPD)-specific hyporesponsiveness in Mycobacterium bovis BCG-vaccinated human T-cell leukemia virus type 1 (HTLV-1)-infected individuals, we examined cytokine production in response to PPD in the following four groups of individuals: (i) HTLV-negative, PPD
- Deficient antibody-dependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection.
- Unique Identifier : AIDSLINE MED/99403272 P P
- Ziegner U; Campbell D; Weinhold K; Frank I; Rutstein R; Starr SE
- A new sensitive serological assay for detection of lentivirus infections in small ruminants.
- Clin Diagn Lab Immunol. 1999 Sep;6(5):734-40. Unique Identifier : AIDSLINE MED/99403275
- Saman E; Van Eynde G; Lujan L; Extramiana B; Harkiss G; Tolari F; Gonzalez L; Amorena B; Watt N; Badiola J; Innogenetics NV, B-9052 Zwijnaarde, Belgium.; ericsam@innogenetics.be
- Lentivirus infections in small ruminants represent an economic problem affecting several European countries with important sheep-breeding industries. Programs for control and eradication of these infections are being initiated and require reliable screening assays. This communication describes the construction and eva
- Th1 cytokine patterns in cervical human papillomavirus infection.
- Clin Diagn Lab Immunol. 1999 Sep;6(5):751-5. Unique Identifier : AIDSLINE MED/99403278
- Scott M; Stites DP; Moscicki AB; Department of Pediatrics, University of California, San; Francisco, California 94143, USA. mscott@itsa.ucsf.edu
- The host s immune response to cervical human papillomavirus (HPV) infection is poorly understood. In a longitudinal cohort of women with cervical HPV infections, defined by PCR-based HPV DNA testing, we used exfoliated cervical cells and reverse transcription-PCR to examine the cervical mucosal mRNA expression of cyto
- Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system.
- Gene Ther. 1999 May;6(5):715-28. Unique Identifier : AIDSLINE MED/99434719
- Chang LJ; Urlacher V; Iwakuma T; Cui Y; Zucali J; Department of Molecular Genetics and Microbiology, University of; Florida Brain Institute, Gainesville, USA.
- Lentiviruses infect both dividing and nondividing cells. In this study we characterized a lentiviral vector system consisting of a packaging vector (pHP) and a transducing vector (pTV) derived from a recombinant human immunodeficiency virus type 1 (HIV-1). In pHP, the long terminal repeats (LTRs), the 5 untranslated
- Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity.
- Gene Ther. 1999 May;6(5):833-9. Unique Identifier : AIDSLINE MED/99434733
- Mendiratta SK; Quezada A; Matar M; Wang J; Hebel HL; Long S; Nordstrom JL; Pericle F; GeneMedicine, Inc. The Woodlands, TX 77381-4248, USA.
- We have utilized a nonviral, polymeric interactive non-condensing (PINC) gene delivery system to deliver IL-12 to two different types of murine tumors, an immunogenic renal cell carcinoma, Renca, and a non-immunogenic colon cell carcinoma, CT26. The delivery of IL-12/polyvinyl pyrrolidone (PVP) complexes into Renca le
- Targeted RNases: a feasibility study for use in HIV gene therapy.
- Gene Ther. 1999 May;6(5):913-21. Unique Identifier : AIDSLINE MED/99434742
- Singwi S; Ramezani A; Ding SF; Joshi S; Department of Medical Genetics and Microbiology, Faculty of; Medicine, University of Toronto, Canada.
- A targeted RNase would be ideal for gene therapy of several acquired and inherited disorders. Such an RNase may be engineered to contain a ribonucleolytic domain and a specific target RNA binding domain. To demonstrate the feasibility of this approach, an RNase targeted against human immunodeficiency virus (HIV) RNA--
- Transgene expression, but not gene delivery, is improved by adhesion-assisted lipofection of hematopoietic cells.
- Gene Ther. 1999 May;6(5):931-8. Unique Identifier : AIDSLINE MED/99434744
- Keller H; Yunxu C; Marit G; Pla M; Reiffers J; Theze J; Froussard P; Departement d'Immunologie, Institut Pasteur, Paris, France.
- In contrast to adherent cells, cells growing in suspension and particularly hematopoietic cells, are notoriously difficult to transfect in vitro using nonviral approaches. In the present study, the effect of cell adhesion on gene transfer efficacy was investigated by allowing hematopoietic cells to bind to an adherent
- Suppression of HIV-1 transcription and replication by a Vpr mutant.
- Gene Ther. 1999 May;6(5):947-50. Unique Identifier : AIDSLINE MED/99434747
- Sawaya BE; Khalili K; Rappaport J; Serio D; Chen W; Srinivasan A; Amini S; Center for NeuroVirology and NeuroOncology, MCP Hahnemann; University, Philadelphia, PA 19102, USA.
- Vpr, the 96 amino acid long protein represents one of the auxiliary proteins of human immunodeficiency virus type-1 (HIV-1), which exhibits the ability to increase the rate of replication of the virus in T cells. Structurally, this protein is composed of several regions such as the acidic domain with alpha helix at th
- Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function.
- Immunity. 1999 Sep;11(3):271-80. Unique Identifier : AIDSLINE MED/99442163
- Saparov A; Wagner FH; Zheng R; Oliver JR; Maeda H; Hockett RD; Weaver CT; Department of Pathology, University of Alabama at Birmingham,; 35294, USA.
- Single cell studies have identified intraclonal heterogeneity of cytokine production by activated T cells. To investigate implications of cytokine heterogeneity for cell fate, an interleukin (IL)-2 promoter-green fluorescent protein (GFP) reporter transgenic model was developed to track
- Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells.
- Immunity. 1999 Sep;11(3):349-58. Unique Identifier : AIDSLINE MED/99442171
- Steinhoff U; Brinkmann V; Klemm U; Aichele P; Seiler P; Brandt U; Bland PW; Prinz I; Zugel U; Kaufmann SH; Department of Immunology, Max-Planck Institute of Infection; Biology, Germany. steinhoff@mpiib-berlin.mpg.de
- Due to their ubiquitous distribution and high degree of structural similarity, heat shock proteins (hsp) are potential target antigens in autoimmune diseases. Here, we describe induction of intestinal inflammation following transfer of hsp60-reactive CD8 T cells into mice. Inflammatory reactions were MHC class I depen
- Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.
- Immunity. 1999 Oct;11(4):399-409. Unique Identifier : AIDSLINE MED/20015815
- Fowell DJ; Shinkai K; Liao XC; Beebe AM; Coffman RL; Littman DR; Locksley RM; Department of Medicine, University of California San Francisco; 94143, USA.
- Naive Itk-deficient CD4+ T cells were unable to establish stable IL-4 production, even when primed in Th2-inducing conditions. In contrast, IFNgamma production was little affected. Failure to express IL-4 occurred even among cells that had gone through multiple cell divisions and was associated with a delay in the kin
- Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.
- Immunity. 1999 Oct;11(4):473-82. Unique Identifier : AIDSLINE MED/20015822
- Zhang DH; Yang L; Cohn L; Parkyn L; Homer R; Ray P; Ray A; Department of Medicine, Yale University School of Medicine, New; Haven, Connecticut 06520, USA.
- The cytokines IL-4, IL-5, and IL-13, secreted by Th2 cells, have distinct functions in the pathogenesis of asthma. We have previously shown that the transcription factor GATA-3 is expressed in Th2 but not Th1 cells. However, it was unclear whether GATA-3 controls the expression of all Th2 cytokines. Expression of a do
- CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.
- Immunity. 1999 Oct;11(4):483-93. Unique Identifier : AIDSLINE MED/20015823
- Shrikant P; Khoruts A; Mescher MF; Center for Immunology, Department of Laboratory Medicine and; Pathology, University of Minnesota, Minneapolis 55455, USA.
- A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap
- Autoimmunity is a type I interferon-deficiency syndrome corrected by ingested type I IFN via the GALT system.
- J Interferon Cytokine Res. 1999 Aug;19(8):841-52. Unique Identifier : AIDSLINE MED/99404577
- Brod SA; Department of Neurology, Graduate School of Biomedical Sciences; in Immunology, University of Texas Health Science Center at; Houston, 77030, USA. sbrod@neuro.med.uth.tmc.edu
- Type I interferons (IFN-alpha/beta), products of the innate immune system, can modulate immune function whereas proinflammatory IFN-gamma (type II IFN), a product of the acquired immune system upregulates inflammation and enhances cell mediated immunity. We have proposed a unifying hypothesis of the origin of autoimmu
- Serum levels of apoptosis-related molecules in patients with multiple sclerosis and human T-lymphotropic virus Type I-associated myelopathy.
- J Interferon Cytokine Res. 1999 Sep;19(9):999-1004. Unique Identifier : AIDSLINE MED/99433560
- Sakai T; Inoue A; Koh CS; Osame M; Department of Medicine (Neurology), Shinshu University School of; Medicine, Matsumoto, Japan.
- We evaluated the presence of soluble Fas (sFas), Fas ligand (sFasL), and Bcl-2 in the sera of patients with multiple sclerosis (MS) or human T-lymphotropic virus type I (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). Patients with MS in the active phase had higher sFas and Bcl-
- Interleukin-10: an anti-inflammatory cytokine with therapeutic potential.
- Clin Exp Allergy. 1999 Sep;29(9):1164-71. Unique Identifier : AIDSLINE MED/99398213
- Pretolani M; Unite de Pharmacologie cellulaire/INSERM U485, Institut Pasteur,; Paris, France.
- Specific inhibition of TH2-type cytokine production from human peripheral T cells by terfenadine in vitro.
- Clin Exp Allergy. 1999 Sep;29(9):1281-6. Unique Identifier : AIDSLINE MED/99398228
- Munakata Y; Umezawa Y; Iwata S; Dong RP; Yoshida S; Ishii T; Morimoto C; Division of Tumor Immunology, Dana-Farber Cancer Institute,; Boston, MA 02115, USA.
- BACKGROUND: Cytokine imbalance is thought to be one of the causes for allergic diseases. The effect of anti-allergic drugs on cytokine production from T cells should be examined in a convenient way. OBJECTIVES: To study the in vitro effect of terfenadine, a prototype non-sedating H1 receptor antagonist, on cytokine pr
- A decision guideline for emergency department utilization of noncontrast head computed tomography in HIV-infected patients.
- Acad Emerg Med. 1999 Oct;6(10):1010-9. Unique Identifier : AIDSLINE MED/99458242
- Rothman RE; Keyl PM; McArthur JC; Beauchamp NJ Jr; Danyluk T; Kelen GD; Department of Emergency Medicine, The Johns Hopkins University; School of Medicine, Baltimore, MD 21287-2070, USA.; rrothman@jhmi.edu
- OBJECTIVE: To determine which neurologic signs or symptoms are predictive of new focal lesions on head CT in HIV-infected patients. METHODS: Prospective study with convenience sample enrollment of HIV-infected patients who presented to a large inner-city university-based ED over an 11-month period. Patients were asses
- Occupational exposures to blood among emergency medicine residents.
- Acad Emerg Med. 1999 Oct;6(10):1036-43. Unique Identifier : AIDSLINE MED/99458246
- Lee CH; Carter WA; Chiang WK; Williams CM; Asimos AW; Goldfrank LR; Department of Emergency Medicine, NYU Medical Center/Bellevue; Hospital Center, NYU School of Medicine, New York, NY, USA.
- OBJECTIVES: To investigate the epidemiologic characteristics of potentially infectious occupational exposures to blood among emergency medicine (EM) residents. METHODS: A SAEM-sponsored multiple-choice survey was administered anonymously to all EM residents participating in the 1998 American Board of Emergency Medicin
- AIDS drug trials in Thailand and Uganda [letter]
- Nat Med. 1999 Nov;5(11):1217. Unique Identifier : AIDSLINE MED/20015158
- Simonds RJ
- SAAVI awards first AIDS vaccine grants [news]
- Nat Med. 1999 Nov;5(11):1220. Unique Identifier : AIDSLINE MED/20015162
- Birmingham K
- PACHA adopts more lenient stance to government efforts [news]
- Nat Med. 1999 Nov;5(11):1220-1. Unique Identifier : AIDSLINE MED/20015161
- Watanabe M
- Complaint upheld against university ethics committee [news]
- Nat Med. 1999 Nov;5(11):1224. Unique Identifier : AIDSLINE MED/20015171
- Dickson D
- The great escape - AIDS viruses and immune control [news]
- Nat Med. 1999 Nov;5(11):1233-5. Unique Identifier : AIDSLINE MED/20015179
- Goulder PJ; Walker BD
- Many studies have been designed to address the role of CTL immune escape in HIV-1 infection, but have not given conclusive answers. Now, an elegant longitudinal analysis clearly demonstrates that progression to disease in SIV-infected macaques is associated with evasion of the CTL response (pages 1270-1276).
- Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.
- Nat Med. 1999 Nov;5(11):1270-6. Unique Identifier : AIDSLINE MED/20015190
- Evans DT; O'Connor DH; Jing P; Dzuris JL; Sidney J; da Silva J; Allen TM; Horton H; Venham JE; Rudersdorf RA; Vogel T; Pauza CD; Bontrop RE; DeMars R; Sette A; Hughes AL; Watkins DI; Wisconsin Regional Primate Research Center, University of; Wisconsin, 1220 Capitol Court, Madison, Wisconsin 53715, USA.
- Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of si
- [Primary cerebral lymphoma in a patient with HIV infection on antiretroviral treatment (letter)]
- Rev Neurol. 1999 May 1-15;28(9):928-9. Unique Identifier : AIDSLINE MED/99319235
- Correa-Nazco VJ; Romero-Perez JC; Martin V; Laynez-Cerdena P; Miguelez-Morales M; Linares-Feria M
- HIV/AIDS and infection control: the debate continues [letter; comment]
- J Can Dent Assoc. 1999 Sep;65(8):426-7. Unique Identifier : AIDSLINE MED/99446601
- McCarthy GM; MacDonald JK
- HIV/AIDS and infection control: the debate continues [letter; comment]
- J Can Dent Assoc. 1999 Sep;65(8):427-8. Unique Identifier : AIDSLINE MED/99446603
- McCarthy GM; MacDonald JK; John MA
- HIV/AIDS and infection control: the debate continues [letter; comment]
- J Can Dent Assoc. 1999 Sep;65(8):428. Unique Identifier : AIDSLINE MED/99446604
- Neiburger EJ
- HIV/AIDS and infection control: the debate continues [letter; comment]
- Unique Identifier : AIDSLINE MED/99446605
- Black KM
- HIV/AIDS and infection control: the debate continues [letter; comment]
- J Can Dent Assoc. 1999 Sep;65(8):461. Unique Identifier : AIDSLINE MED/99446611
- Kearney P
- [Experimental study on immunity and burn wound healing]
- Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1997 Sep;13(5):326-9. Unique Identifier : AIDSLINE MED/99381345
- Chen Y; Fang Y; Yi C; Burns Center, Changhai Hospital, Second Military Medical; University, Shanghai.
- The immune system is involved in the complicated process of wound healing. In this study, we at first set up an optimal immuno-suppression model with low-doze radiation with 60Co and found that both the ratio of Th/Ts in peripheral blood and the rate of T cells adhesion to tumour cells dropped persistently, and there
- The Lazarus syndrome: a second chance for life with HIV infection.
- J Am Pharm Assoc (Wash). 1999 Jul-Aug;39(4):462-6. Unique Identifier : AIDSLINE MED/99397140
- Scott S; Constantine LM
- Zidovudine (AZT) induced alterations in mitochondrial biogenesis in rat striated muscles.
- Can J Physiol Pharmacol. 1999 Jan;77(1):29-35. Unique Identifier : AIDSLINE MED/20004321
- Freyssenet D; DiCarlo M; Escobar P; Grey J; Schneider J; Hood DA; Department of Biology, York University, Toronto, Canada.
- Zidovudine ( AZT ) and didanosine (ddI), two drugs used in the treatment of AIDS, are also known to cause mitochondrial abnormalities. We investigated the physiological relevance of the mitochondrial defects by measuring in situ skeletal muscle performa
- Interaction of oligonucleotides conjugated to substituted chromones and coumarins with HIV-1 reverse transcriptase.
- Antisense Nucleic Acid Drug Dev. 1999 Oct;9(5):473-80. Unique Identifier : AIDSLINE MED/20021626
- Martyanov IV; Zakharova OD; Sottofattori E; Pyshnyi DV; Yurchenko EY; Babbi P; Mazzei M; Balbi A; Andreola ML; Litvak S; Tarrago-Litvak L; Nevinsky GA; Novosibirsk Institute of Bioorganic Chemistry, Siberian Division; of the Russian Academy of Sciences.
- Ten different pyranone-related substituents (chromones or coumarins) were covalently linked to the 5 end of various oligonucleotides (ODN). The interaction of these compounds with human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) was analyzed. A different behavior was found to depend on the struc
- Nuclear proliferation in syncytia during avian reovirus replication.
- Can J Vet Res. 1999 Oct;63(4):282-3. Unique Identifier : AIDSLINE MED/20001575
- Tsukamoto Y; Kotani T; Kohama K; Sakuma S; Sasaki F; Department of Veterinary Anatomy, College of Agriculture, Osaka; Prefecture University, Sakai, Japan.; ytsuka@jyui.vet.osakafu-u.ac.jp
- Cultured chick embryonic fibroblasts formed syncytia after infection with avian reovirus (ARV) strain 58-132. Mitotic figures were occasionally observed within the syncytia. In addition, many nuclei in the syncytia incorporated 5-bromo-2 -deoxyuridine (BrdU), a DNA replication marker, indicating that they were in the
- Progressive multifocal leukoencephalitis (PML) in three patients treated with standard-dose fludarabine (FAMP).
- Hematol Cell Ther. 1999 Aug;41(4):183-6. Unique Identifier : AIDSLINE MED/20008720
- Gonzalez H; Bolgert F; Camporo P; Leblond V; Service d'Hematologie, Hopital Pitie-Salpetriere, Paris.
- Since 1990 we have treated 60 patients with standard-dose fludarabine for chronic lymphocytic leukemia (B-CLL), on a compassionate basis. Three patients developed grade IV neurologic complications after treatment, with demyelination of white matter on magnetic resonance imaging (MRI) in patient # 1, diffuse demyelinat
- Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases.
- Cell Mol Life Sci. 1999 Sep;55(12):1610-25. Unique Identifier : AIDSLINE MED/99455498
- Adorini L; Roche Milano Ricerche, Italy.
- Interleukin 12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-presenting cells (APCs) which plays a key role in promoting type 1 T helper cell (Th1) responses. The powerful activity of IL-12 requires tight control, which is exerted at various levels. Primary control is exerted on IL-12 production by
- Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma.
- Cancer. 1999 Oct 15;86(8):1537-43. Unique Identifier : AIDSLINE MED/20010004
- Sheu BC; Hsu SM; Ho HN; Lin RH; Torng PL; Huang SC; Department of Obstetrics and Gynecology, National Taiwan; University College of Medicine, Taipei, Taiwan.
- BACKGROUND: To investigate the clinical significance of tumor-infiltrating lymphocytes (TILs) within the tumor milieu of human cervical carcinoma, the authors quantitatively measured and compared the subpopulations of lymphocytes infiltrating the neoplastic cervix. METHODS: A total of 30 patients with Stage Ia-IIa cer
- Computed tomography of the thorax in HIV disease.
- Eur Radiol. 1999;9(8):1556-69. Unique Identifier : AIDSLINE MED/99457239
- Padley SP; King LJ; Department of Radiology, Chelsea and Westminster Hospital, 369; Fulham Road, London SW10 9NH, UK.
- A wide variety of thoracic disorders can arise in patients infected with the human immunodeficiency virus (HIV), although recent developments in the therapeutic management of AIDS patients has resulted in a changing pattern of chest disease. The use of CT in the diagnosis and management of these thoracic manifestation
- New insights into human cryptosporidiosis.
- Clin Microbiol Rev. 1999 Oct;12(4):554-63. Unique Identifier : AIDSLINE MED/99445442
- Clark DP; Department of Pathology and Laboratory Medicine, The Johns; Hopkins School of Medicine, Baltimore, Maryland 21287, USA.; dclark@jhmi.edu
- Cryptosporidium parvum is an important cause of diarrhea worldwide. Cryptosporidium causes a potentially life-threatening disease in people with AIDS and contributes significantly to morbidity among children in developing countries. In immunocompetent adults, Cryptosporidium is often associated with waterborne outbrea
- Plant products as antimicrobial agents.
- Clin Microbiol Rev. 1999 Oct;12(4):564-82. Unique Identifier : AIDSLINE MED/99445443
- Cowan MM; Department of Microbiology, Miami University, Oxford, Ohio 45056,; USA. cowanmm@muohio.edu
- The use of and search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethnopharmacologists, botanists, microbiologists, and natural-products chemists are combing the Earth for phytochemicals and leads which could be developed for treatment of infectious diseases. While 25 to 5
- Methods for subtyping and molecular comparison of human viral genomes.
- Clin Microbiol Rev. 1999 Oct;12(4):612-26. Unique Identifier : AIDSLINE MED/99445445
- Arens M; Edward Mallinckrodt Department of Pediatrics, Washington; University School of Medicine, St. Louis, Missouri 63110, USA.; arens@kidsa1@wustl.edu
- The development over the past two decades of molecular methods for manipulation of RNA and DNA has afforded molecular virologists the ability to study viral genomes in detail that has heretofore not been possible. There are many molecular techniques now available for typing and subtyping of viruses. The available meth
- Covariation of physical and mental symptoms across illnesses: results of a factor analytic study.
- Ann Behav Med. 1999 Spring;21(2):122-7. Unique Identifier : AIDSLINE MED/99428920
- Schwartz CE; Kaplan RM; Anderson JP; Holbrook T; Genderson MW; Frontier Science & Technology Research Foundation, Inc., Chestnut; Hill, MA 02467, USA.
- OBJECTIVE: Chronic illnesses are associated with reports of symptoms, problems, and dysfunction along multiple dimensions. To determine if the dimensionality is disease-specific and whether physical and emotional symptoms are concomitant and inseparable aspects of the illness experience, we present a factor analysis o
- Potent activity of soluble B7-IgG fusion proteins in therapy of established tumors and as vaccine adjuvant.
- Cancer Res. 1999 Oct 1;59(19):4964-72. Unique Identifier : AIDSLINE MED/99446899
- Sturmhoefel K; Lee K; Gray GS; Thomas J; Zollner R; O'Toole M; Swiniarski H; Dorner A; Wolf SF; Genetics Institute, Andover, Massachusetts 01810, USA.; Knut.Sturmhoefel@emindustries.com
- Fusion proteins consisting of the extracellular region of murine B7.1 or B7.2 and the Fc portion of murine IgG2a (B7-IgG) were evaluated for their ability to promote antitumor responses. Therapeutic administration of soluble B7-IgG in mice with established tumors induced complete regression of the tumor and increased
- Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6.
- Cancer Res. 1999 Oct 1;59(19):4984-9. Unique Identifier : AIDSLINE GENBANK/U90534
- Ojala PM; Tiainen M; Salven P; Veikkola T; Castanos-Velez E; Sarid R; Biberfeld P; Makela TP; Cell Cycle Laboratory, Haartman Institute, University of; Helsinki, Finland. Paivi.Ojala@helsinki.fi
- Kaposi s sarcoma-associated herpesvirus (KSHV) has a key etiological role in development of Kaposi s sarcoma (KS). v-Cyclin is a KSHV-encoded homologue to D-type cyclins that associates with cellular cyclin-dependent kinase 6 (CDK6). v-Cyclin promotes S-phase entry of quiescent cells and has been suggested to execute
- Function and dysfunction of CD4(+) T cells in the immune response to melanoma [see comments]
- Cancer Immunol Immunother. 1999 Oct;48(7):363-70. Unique Identifier : AIDSLINE MED/99431744
- Fischer WH; thor Straten P; Terheyden P; Becker JC; Department of Immunotoxicology, Julius-Maximillians-University,; Wurzburg, Germany.
- A major difficulty for tumor immunotherapy derives from the phenomenon that the encounter of the immune system with an antigen does not necessarily result in activation, but may also be followed by the induction of tolerance either by anergy or physical deletion. It is well established that the immune system becomes a
- Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients.
- Cancer Immunol Immunother. 1999 Nov;48(8):435-42. Unique Identifier : AIDSLINE MED/20019957
- Goto S; Sato M; Kaneko R; Itoh M; Sato S; Takeuchi S; The Institute of Bioregulation, Scarf-Kaikan 5F, 1-2,; Sumiyoshicho, Naka-ku, Yokohama, Kanagawa, 2310013, Japan.
- PURPOSE: The presence of immunological dysfunction has not been well demonstrated in cancer patients. Recent studies have revealed that the immune response can be classified into types 1 and 2, and in the present work the immunological function of patients was studied from the perspective of these two types of respons
- Tumor-specific targeting of T helper type 1 (Th1) cells by anti-CD3 x anti-c-ErbB-2 bispecific antibody.
- Cancer Immunol Immunother. 1999 Nov;48(8):456-62. Unique Identifier : AIDSLINE MED/20019959
- Ohmi Y; Shiku H; Nishimura T; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Tokai University School of; Medicine, Bohseidai, Isehara 259-1193, Japan.
- T helper type1 (Th1) or type2 (Th2) cells were induced from naive Th cells obtained from ovalbumin-specific T cell receptor (TCR) transgenic mice. Th1 cells producing interferon gamma (IFNgamma) exhibited stronger antigen-specific cytotoxicity against ovalbumin-(323-339)-peptide-pulsed A20 tumor cells than did Th2 cel
- HIV and AIDS in Africa: impact on mother and child health.
- Eur J Med Res. 1999 Aug 25;4(8):341-4. Unique Identifier : AIDSLINE MED/99403357
- Van de Perre P; Centre Muraz, Organisation de Coordination et de Cooperation; pour la lutte contre les Grandes Endemies (OCCGE), 01 BP 153,; Bobo-Dioulasso, Burkina Faso. direction.muraz@fasonet.bf
- Mother to child transmission of HIV-1 is a leading challenge of public health in developing countries. Various risk factors for vertical transmission of HIV have been identified, and both prenatal and postnatal infection by breast feeding occur. A bundle of interventions has lead to a dramatic drop of infection rates
- Relation of peripheral neuropathy to HIV treatment in four randomized clinical trials including didanosine.
- Clin Ther. 1999 Jul;21(7):1182-92. Unique Identifier : AIDSLINE MED/99391157
- Kelleher T; Cross A; Dunkle L; Biostatistics and Data Management, Bristol-Meyers Squibb Company,; Wallingford, Connecticut 06492, USA.
- Peripheral neuropathy has been recognized as a dose-limiting adverse effect in Phase I studies of didanosine (ddI) therapy for HIV infection. To study the effect of the currently recommended lower dose of ddI, the databases of 4 randomized, controlled trials were used to assess the frequency of dose-limiting
- Effect of indinavir and higher CD4+ T-cell count on viral load response after 6 months of highly active antiretroviral therapy.
- Clin Ther. 1999 Aug;21(8):1313-20. Unique Identifier : AIDSLINE MED/99413513
- Pradier C; Pesce A; Carrieri P; Cottalorda J; Boyer P; Senesi C; Fuzibet JG; Dellamonica P; Cassuto JP; Centre d'Information et de Soins de l'Immunodeficience Humaine,; Nice, France.
- This retrospective, unmasked chart review was undertaken to determine which HIV-infected patients receiving protease inhibitors (PIs) for the first time were most likely to experience a decrease in plasma viral load (PVL) and which factors were associated with a PVL
- Management of HIV-infected pregnant patients in malaria-endemic areas: therapeutic and safety considerations in concomitant use of antiretroviral and antimalarial agents.
- Clin Ther. 1999 Sep;21(9):1456-96; discussion 1427-8. Unique Identifier : AIDSLINE MED/99437543
- Okereke CS; Department of Pharmacy Practice, University of Rhode Island; College of Pharmacy, Roger Williams Medical Centre, Providence,; USA.
- Chemotherapy in pregnancy is an intricate process requiring prudent use of pharmacologic agents. Malarial infection during pregnancy is often fatal, and prophylaxis against the causative parasite necessitates rational therapeutic intervention. Various agents have been used for prophylaxis against malaria during pregna
- Tyramide signal amplification method in multiple-label immunofluorescence confocal microscopy.
- Methods. 1999 Aug;18(4):459-64. Unique Identifier : AIDSLINE MED/99423778
- Wang G; Achim CL; Hamilton RL; Wiley CA; Soontornniyomkij V; Department of Pathology (Neuropathology), University of; Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,; USA.
- The tyramide signal amplification (TSA) method has recently been introduced to improve the detection sensitivity of immunohistochemistry. We present three examples of applying this method to immunofluorescence confocal laser microscopy: (1) single labeling for CD54 in frozen mouse brain tissue; (2) double labeling wit
- Interleukin-18.
- Methods. 1999 Sep;19(1):121-32. Unique Identifier : AIDSLINE MED/99457556
- Dinarello CA; Division of Infectious Diseases, B168, University of Colorado; Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado; 80262, USA.
- Interleukin (IL)-18 is a newly discovered cytokine, structurally similar to IL-1, with profound effects on T-cell activation. This short review summarizes the present knowledge on IL-18, to give an insight into the future perspectives for its possible use as vaccine adjuvant. Formerly called interferon (IFN) gamma ind
- Local lymph node assay: differentiating allergic and irritant responses using flow cytometry.
- Methods. 1999 Sep;19(1):48-55. Unique Identifier : AIDSLINE MED/99457545
- Gerberick GF; Cruse LW; Ryan CA; Miami Valley Laboratories, The Procter and Gamble Company,; Cincinnati, Ohio 45239-8707, USA. gerberick.gf@pg.com
- The murine local lymph node assay (LLNA) is a method for assessing the contact sensitization potential of chemicals. Based on events that occur during the induction phase of a contact sensitization response, the LLNA measures the in vivo proliferation of cells in the draining lymph nodes (DLNs) of mice following topic
- Cytokine fingerprinting: characterization of chemical allergens.
- Methods. 1999 Sep;19(1):56-63. Unique Identifier : AIDSLINE MED/99457546
- Dearman RJ; Kimber I; Astra Zeneca Central Toxicology Laboratory, Alderley Park,; Macclesfield, Cheshire, SK10 4TJ, United Kingdom.; Rebecca.Dearman@CTL.ZENECA.com
- Chemical allergy is a common and important occupational health issue. Allergic sensitization induced by chemicals may take a variety of forms, including allergic contact dermatitis (skin sensitization) and allergic asthma and rhinitis (sensitization of the respiratory tract). There is a need to identify and characteri
- Quantitation of cytokine mRNA expression as an endpoint for prediction and diagnosis of xenobiotic-induced hypersensitivity reactions.
- Methods. 1999 Sep;19(1):64-70. Unique Identifier : AIDSLINE MED/99457547
- Gaspard I; Kerdine S; Pallardy M; Lebrec H; Immunotoxicology Group, Faculte de Pharmacie de l'Universite; Paris XI, rue Jean-Baptiste Clement, Chatenay-Malabry, 92296,; France.
- Xenobiotic-induced hypersensitivity reactions are immune-mediated effects that involve specific antibodies and/or effector and regulatory T lymphocytes. Cytokines are key mediators of such responses and must be considered as possible endpoints for predicting sensitizing potency of drugs and chemicals, as well as for h
- Immunomodulation by iscoms, immune stimulating complexes.
- Methods. 1999 Sep;19(1):94-102. Unique Identifier : AIDSLINE MED/99457552
- Morein B; Bengtsson KL; Department of Veterinary Microbiology, Swedish University of; Agricultural Sciences, Uppsala, Sweden. Bror.Morein@sva.se
- The iscom is a uniform stable complex consisting of cholesterol, phospholipid, adjuvant-active saponin, and antigen. The iscom matrix is a particulate complex with identical composition, shape, and morphology, but lacking the incorporated antigen. The assembly of the complex is based on hydrophobic interactions, but a
- Do black and white adults use the same sources of information about AIDS prevention?
- Health Educ Behav. 1999 Oct;26(5):703-13. Unique Identifier : AIDSLINE MED/20003367
- Cunningham WE; Davidson PL; Nakazono TT; Andersen RM; Department of Medicine, School of Medicine, University of; California, Los Angeles 90095, USA.; wcunning@medicine.medsch.ucla.edu
- Although AIDS prevention campaigns need to target population segments that are at highest risk to be effective, little is known about how various sources of AIDS information vary by race, education, and age. To determine the most common communication channels for AIDS information reported by Blacks and Whites, the aut
- World Bank task force push/pulls AIDS vaccines [news]
- Nat Biotechnol. 1999 Sep;17(9):846-7. Unique Identifier : AIDSLINE MED/99403325
- Dove A
- Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.
- Cell. 1999 Oct 1;99(1):103-15. Unique Identifier : AIDSLINE PDB/1CZQ
- Eckert DM; Malashkevich VN; Hong LH; Carr PA; Kim PS; Howard Hughes Medical Institute, Whitehead Institute for; Biomedical Research, Department of Biology, Massachusetts; Institute of Technology, Cambridge 02142, USA.
- The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents
- HIV-1 entry inhibitors in the side pocket.
- Cell. 1999 Oct 29;99(3):243-6. Unique Identifier : AIDSLINE MED/20021611
- Sodroski JG; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.
- Induction of CD4(+) and CD8(+) Bordetella pertussis toxin subunit S1 specific T cells by immunization with synthetic peptides.
- Cell Immunol. 1999 Sep 15;196(2):110-21. Unique Identifier : AIDSLINE MED/99458813
- Fagerberg J; Askelof P; Wigzell H; Mellstedt H; Department of Oncology (Radiumhemmet), Immune and Gene Therapy; Laboratory, Cancer Center Karolinska, Karolinska Institute,; Stockholm, Sweden.
- In this study two synthetic peptides from the Bordetella pertussis toxin subunit S1 were conjugated to human anti-idiotypic antibodies and used as an immunogen in cancer patients to induce immunity. The aims of the present report are to explain why no carrier or adjuvant effect of the conjugated pertussis peptides cou
- Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions.
- Cell Immunol. 1999 Sep 15;196(2):122-30. Unique Identifier : AIDSLINE MED/99458814
- Raghupathy R; Makhseed M; Azizieh F; Hassan N; Al-Azemi M; Al-Shamali E; Department of Microbiology, Faculty of Medicine, Kuwait; University.
- Spontaneous abortion is the most common complication of pregnancy, but the etiology of a significant proportion of abortions is still unknown. We have examined the production of Th1- and Th2-type cytokines by women with unexplained recurrent spontaneous abortion (RSA) since it appears that successful murine pregnancy
- Murine T cell determination of pregnancy outcome.
- Cell Immunol. 1999 Sep 15;196(2):71-9. Unique Identifier : AIDSLINE MED/99458808
- Arck PC; Ferrick DA; Steele-Norwood D; Egan PJ; Croitoru K; Carding SR; Dietl J; Clark DA; Medizinische Fakultat der Humbolt, Universitat zu Berlin,; Augustenburger Platz, Berlin, 13353, Germany.
- At the fetomaternal interface, maternal effector cells come in intimate contact with fetal trophoblast cells which express paternal antigens. Failure of fetal trophoblast cells to activate maternal Th1 immune responses has been attributed in part to the absence of classical Class I and Class II major histocompatibilty
- The role of CD80 and CD86 in enhancing CD8(+) cell suppression of HIV replication.
- Cell Immunol. 1999 Sep 15;196(2):95-103. Unique Identifier : AIDSLINE MED/99458811
- Barker E; Bossart KN; Fujimura SH; Levy JA; Department of Medicine, University of California, San Francisco,; California 94143-1270, USA.
- CD8(+) cells activated in the presence of autologous macrophages (Mphi) have an increased ability to suppress HIV replication compared to the same cells stimulated in the absence of Mphi. Blocking the B7 molecules decreases the ability of Mphi to increase CD8(+) cell antiviral activity. In the present study CD8(+) cel
- Expressing estimators of expected quality adjusted survival as functions of Nelson-Aalen estimators.
- Lifetime Data Anal. 1999 Sep;5(3):199-212. Unique Identifier : AIDSLINE MED/99446638
- Huang Y; Louis TA; Division of Public Health Sciences, Fred Hutchinson Cancer; Research Center, Seattle, WA, USA. eugene@hivnet.fhcrc.org
- Quality adjusted survival has been increasingly advocated in clinical trials to be assessed as a synthesis of survival and quality of life. We investigate nonparametric estimation of its expectation for a general multistate process with incomplete follow-up data. Upon establishing a representation of expected quality
- HIV-1 nuclear import: in search of a leader.
- Front Biosci. 1999 Oct 15;4:D772-81. Unique Identifier : AIDSLINE MED/20006918
- Bukrinsky MI; Haffar OK; The Picower Institute for Medical Research, Manhasset, NY 11030,; USA. mbukrinsky@picower.edu
- The ability of HIV-1 to use host cell nuclear import machinery to translocate the viral pre-integration complex into the cell nucleus is the critical determinant in the replication of the virus in non-dividing cells, such as macrophages. In this review, we describe the viral and cellular factors involved in this proce
- Case management: client and manager perspectives.
- Nurs Case Manag. 1998 Jul-Aug;3(4):168-71. Unique Identifier : AIDSLINE MED/99073294
- Highsmith C; Highsmith Consulting, Shorewood, Wisconsin, USA.
- A step ahead of the law, "Compassion Club" sells marijuana to patients referred by MDs [news]
- CMAJ. 1999 Oct 19;161(8):1024. Unique Identifier : AIDSLINE MED/20018900
- Kent H
- Reversed-phase high-performance liquid chromatographic assay for the adenovirus type 5 proteome.
- J Chromatogr B Biomed Sci Appl. 1999 Sep 24;732(2):411-23. Unique Identifier : AIDSLINE MED/99444952
- Lehmberg E; Traina JA; Chakel JA; Chang RJ; Parkman M; McCaman MT; Murakami PK; Lahidji V; Nelson JW; Hancock WS; Nestaas E; Pungor E Jr; Berlex Laboratories, Inc., Richmond, CA 94804-0099, USA.; elisabeth_lehmberg@Berlex.com
- An RP-HPLC assay was developed for a recombinant adenovirus type 5. During chromatography, intact adenovirus dissociated into its structural components (DNA and proteins) and the viral proteome was separated yielding a characteristic fingerprint. The individual components were identified by matrix-assisted laser desor
- Determination of L-756 423, a novel HIV protease inhibitor, in human plasma and urine using high-performance liquid chromatography with fluorescence detection.
- J Chromatogr B Biomed Sci Appl. 1999 Sep 24;732(2):425-35. Unique Identifier : AIDSLINE MED/99444953
- Rose MJ; Merschman SA; Woolf EJ; Matuszewski BK; Merck Research Laboratories, Department of Drug Metabolism, West; Point, PA 19486, USA. mark_rose@merck.com
- A method for the determination of L-756 423, a novel HIV protease inhibitor, in human plasma and urine is described. Plasma and urine samples were extracted using 3M Empore extraction disk cartridges in the C18 and MPC (mixed-phase cation-exchange) formats, respectively. The extract was analyzed using HPLC with fluore
- Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.
- Int J Oncol. 1999 Oct;15(4):769-73. Unique Identifier : AIDSLINE MED/99425424
- Seetharam S; Staba MJ; Schumm LP; Schreiber K; Schreiber H; Kufe DW; Weichselbaum RR; Department of Radiation and Cellular Oncology, University of; Chicago, Chicago, IL 60637, USA.
- Ionizing radiation (IR) is frequently unsuccessful in the treatment of cancer because of local failure or distant metastases. The efficacy of systemically administered cytokines for cancer therapy is often limited by toxicity. We report that intratumoral injection of an adenoviral vector with interleukin-12 (IL-12) en
- Bone marrow cultures for the diagnosis of mycobacterial and fungal infections in patients infected with the human immunodeficiency virus.
- Int J Tuberc Lung Dis. 1999 Oct;3(10):908-12. Unique Identifier : AIDSLINE MED/99452220
- Talbot EA; Reller LB; Frothingham R; Department of Medicine, Duke University Medical Center, Durham,; North Carolina, USA.
- SETTING: University medical center. OBJECTIVE: To determine the value of bone marrow cultures for mycobacteria and fungi in patients infected with the human immunodeficiency virus (HIV). DESIGN: Retrospective review of charts and laboratory records. RESULTS: From 1992-1996, 1225 bone marrow specimens were submitted fo
- Immune mediated 'HAART' attack during treatment for tuberculosis. Highly active antiretroviral therapy.
- Int J Tuberc Lung Dis. 1999 Oct;3(10):944-7. Unique Identifier : AIDSLINE MED/99452225
- Kunimoto DY; Chui L; Nobert E; Houston S; Department of Medical Microbiology and Immunology, University of; Alberta, Canada. Dennis.Kunimoto@Ualberta.ca
- Highly active antiretroviral therapy (HAART) suppresses viral replication and improves immune function. However the inflammatory component of immune restoration can have clinically deleterious effects on previously asymptomatic infections. We report the development of acute respiratory failure in a patient after the i
- Natural history of human immunodeficiency virus type 1 infection in children: a five-year prospective study in Rwanda. Mother-to-Child HIV-1 Transmission Study Group
- Pediatrics. 1999 Nov;104(5):e56. Unique Identifier : AIDSLINE MED/20015338
- Spira R; Lepage P; Msellati P; Van De Perre P; Leroy V; Simonon A; Karita E; Dabis F; Unite INSERM U 330, Universite Victor Segalen Bordeaux 2,; Bordeaux, France. rosemary.spira@dim.u-bordeaux2.fr
- OBJECTIVE: To compare morbidity and mortality of human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected children and to identify predictors of acquired immunodeficiency syndrome (AIDS) and death among HIV-1-infected children in the context of a developing country. DESIGN: Prospective cohort study. S
- Sleep disturbances in children with human immunodeficiency virus infection.
- Pediatrics. 1999 Nov;104(5):e62. Unique Identifier : AIDSLINE MED/20015344
- Franck LS; Johnson LM; Lee K; Hepner C; Lambert L; Passeri M; Manio E; Dorenbaum A; Wara D; School of Nursing, University of California San Francisco, San; Francisco, California 94143, USA. lfranck@itsa.ucsf.edu
- OBJECTIVE: To describe the sleep patterns and level of fatigue in children and adolescents (6-18 years of age) with HIV infection, compared with ethnic-, gender-, and age-matched healthy children in the home setting. DESIGN: Descriptive, comparative. SETTING: Conducted in each child s home environment. STUDY PARTICIPA
- Nucleosides and nucleotides. 186. Synthesis and biological activities of pyrimidine carbocyclic nucleosides with a hydroxyamino group instead of a hydroxymethyl group at the 4'-position of the sugar moiety.
- Chem Pharm Bull (Tokyo). 1999 Jul;47(7):1000-5. Unique Identifier : AIDSLINE MED/99363245
- Ogawa A; Shuto S; Tanaka M; Sasaki T; Mori S; Shigeta S; Matsuda A; Graduate School of Pharmaceutical Sciences, Hokkaido University,; Sapporo, Japan.
- Pyrimidine carbocyclic nucleosides with a hydroxyamino group instead of a hydroxymethyl group at the 4 -position of the sugar moiety were designed as potential antitumor and/or antiviral agents. Pd (O)-catalyzed reactions of enantiomerically pure (+)-(1R,4S)-4-[(tert-butyldiphenylsilyl)oxy]-1-(ethoxycarbonylo xy)-2- c
- Sequences homologous to the mouse mammary tumor virus env gene in human breast carcinoma correlate with overexpression of laminin receptor.
- Clin Cancer Res. 1999 Aug;5(8):2108-11. Unique Identifier : AIDSLINE MED/99400073
- Pogo BG; Melana SM; Holland JF; Mandeli JF; Pilotti S; Casalini P; Menard S; Department of Medicine, Mount Sinai School of Medicine, New York,; New York 10029, USA. pogo@msvax.mssm.edu
- We previously reported that a 660-bp sequence that is homologous to the env gene of the mouse mammary tumor virus (MMTV) but not to endogenous retroviruses or to other known genes was present in 38% of human breast cancers and in some breast cancer cell lines studied (Y. Wang et al., Cancer Res., 55: 5173-5179, 1995).
- Prognostic significance of Fas and Fas ligand expressions in human esophageal cancer.
- Clin Cancer Res. 1999 Sep;5(9):2464-9. Unique Identifier : AIDSLINE MED/99427966
- Shibakita M; Tachibana M; Dhar DK; Kotoh T; Kinugasa S; Kubota H; Masunaga R; Nagasue N; Second Department of Surgery, Shimane Medical University, Izumo,; Japan. nigeka88@shimane-med.ac.jp
- Esophageal carcinomas have recently been shown to express Fas ligand (FasL) and down-regulate Fas to escape from host immune surveillance. However, the prognostic importance of Fas/FasL and their correlation with clinicopathological characteristics are yet to be delineated in this highly malignant carcinoma. Specimens
- Retinoic acid modulates a bimodal effect on cell cycle progression in human adult T-cell leukemia cells.
- Unique Identifier : AIDSLINE MED/99427977
- Dierov J; Sawaya BE; Prosniak M; Gartenhaus RB; Center for NeuroVirology and NeuroOncology, MCP Hahnemann School; of Medicine, Philadelphia, Pennsylvania 19102, USA.
- Retinoids, the analogues of vitamin A, have a broad range of effects on different cell types. One biologically active form of vitamin A is all-trans-retinoic acid (ATRA), which binds to retinoic acid receptors, as does its intracellular metabolite, 9-cis-RA. Earlier studies have documented G1 cell cycle arrest and the
- Management of CMV retinitis in the era of highly active antiretroviral therapy.
- Int J Antimicrob Agents. 1999 Sep;13(1):1-7. Unique Identifier : AIDSLINE MED/20024922
- Jouan M; Katlama C; Department of Infectious and Tropical Diseases, Hopital; Pitie-Salpetriere, Paris, France.
- Although the epidemiological features of CMV retinitis is changing in patients receiving highly active antiretroviral therapy (HAART), continued attention must be paid to detect and treat earlier CMV infections in AIDS patients to prevent severe ophthalmic compl
- HIV testing in pregnancy.
- Pract Midwife. 1999 Feb;2(2):14-6. Unique Identifier : AIDSLINE MED/99286706
- Ward C; St Mary's Hospital, Paddington.
- Epidemiology and management of diarrheal disease in HIV-infected patients.
- Int J Infect Dis. 1999 Spring;3(3):164-7. Unique Identifier : AIDSLINE MED/99391966
- Katabira ET; Department of Medicine, Makerere Medical School, Kampala, Uganda.; katabira@imul.com
- Diarrhea is the most common gastrointestinal symptom in human immunodeficiency virus (HIV) infection. It affects up to 90% of patients, becoming more frequent and severe as the immune system deteriorates. It often is associated with significant morbidity and mortality particularly in the developing countries. Gastroin
- On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy.
- Int J Infect Dis. 1999 Spring;3(3):168-76. Unique Identifier : AIDSLINE MED/99391967
- Zaninovic V; Emeritus Professor, Clinical Neurology, School of Medicine, Valle; University, Cali, Colombia. vlazani@mafalda.univalle.edu.co
- The purpose of this review is to present some concepts on the etiology of tropical spastic paraparesis or human T-cell lymphotropic virus-I (HTLV-I)-associated myelopathy (TSP/HAM). The large number of syndromes that have been associated with HTLV-I (60 to date), the existence of TSP/HAM cases associated with other re
- Peritoneal tuberculosis: diagnostic options.
- Infect Dis Obstet Gynecol. 1999;7(5):244-7. Unique Identifier : AIDSLINE MED/99452301
- Lal N; Soto-Wright V; Department of Obstetrics and Gynecology, Boston Medical Center,; MA, USA.
- BACKGROUND: Extrapulmonary tuberculosis has vague symptoms and few signs. It is essential to recognize and diagnose this curable disease prior to performing definitive surgery. Newer tests such as DNA or RNA amplification allow for early diagnosis but have limitations. CASE: We report a case of peritoneal tuberculosis
- Homologues of isomeric dideoxynucleosides as potential antiviral agents: synthesis of isodideoxynucleosides with a furanethanol sugar moiety.
- Nucleosides Nucleotides. 1999 Sep;18(9):1961-76. Unique Identifier : AIDSLINE MED/20016864
- Zheng X; Nair V; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.
- The synthesis of a homologues series of compounds related to (R, S)-isodideoxynucleosides has been completed by coupling a variety of natural purine and pyrimidine bases with a modified sugar intermediate. This sugar precursor was prepared regiospecifically and stereospecifically from D-glucose.
- Synthesis and antiviral activity of 1,5- and 1,3-dialkyl-1,2,4-triazole C-nucleosides derived from 1-(chloroalkyl)-1-aza-2-azoniaallene salts.
- Nucleosides Nucleotides. 1999 Sep;18(9):1985-94. Unique Identifier : AIDSLINE MED/20016865
- al-Soud YA; al-Masoudi WA; el-Halawa RA; al-Masoudi N; Department of Chemistry, Al al-Bayt University, Mafraq, Jordan.
- Reactions of alpha,alpha -dichloroazo compounds 2 with SbCl5 gave 1-(chloroalkyl)-1-aza-2-azoniaallene salts 3 as reactive intermediates. Cycloadditions of 3 with the ribofuranosyl cyanide 4 afforded the beta-D-ribofuranosyl-1,2,4-triazolium salts 5, which rearranged spontaneously to salts 6. Hydrolysis of 6 gave the
- Physico-chemical and biological properties of antisense phosphodiester oligonucleotides with various secondary structures.
- Nucleosides Nucleotides. 1999 Sep;18(9):2071-91. Unique Identifier : AIDSLINE MED/20016868
- Maksimenko AV; Gottikh MB; Helin V; Shabarova ZA; Malvy C; Belozersky Institute of Physical Chemical Biology, Lomonosov; Moscow State University, Russia.
- The influence of the secondary structure of oligonucleotides having a natural phosphodiester backbone on their ability to interact with DNA and RNA targets and on their resistance to the nucleolytic digestion is investigated. Oligonucleotides having hairpin, looped and snail-like structure are found to be much more st
- Health risks of travelers in South Africa.
- Unique Identifier : AIDSLINE MED/99398879
- Waner S
- Large numbers of tourists visit South Africa every year. Travelers to urban areas are at little risk of contracting an infectious disease, however the adventure traveler is at increased risk. Yellow fever is not known to occur in South Africa. Malaria is endemic in Mpumalanga and
- Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.
- Bioorg Med Chem Lett. 1999 Aug 2;9(15):2217-22. Unique Identifier : AIDSLINE MED/99393240
- Vara Prasad JV; Markoski LJ; Boyer FE; Domagala JM; Ellsworth EL; Gajda C; Hagen SE; Tait BD; Lunney EA; Tummino PJ; Ferguson D; Holler T; Hupe D; Nouhan C; Gracheck SJ; VanderRoest S; Saunders J; Iyer K; Sinz M; Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann; Arbor, MI 48106, USA.
- Dihydropyran-2-ones possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S3 pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2-t-butyl-5-methyl-4-sulfamate) phenylthio moiety were established. SAR of various sulfamate analogs incl
- Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents.
- Bioorg Med Chem Lett. 1999 Aug 2;9(15):2259-62. Unique Identifier : AIDSLINE MED/99393248
- Kaltenbach RF 3rd; Klabe RM; Cordova BC; Seitz SP; DuPont Pharmaceuticals Company, Experimental Station, Wilmington,; DE 19880-0500, USA.
- A series of alkyl substituted P1/P1 analogs was prepared in an attempt to increase translation of the 3-aminoindazole class of HIV protease inhibitors . Increasing the lipophilicity of the P1/P1 residues dramatically improved translation of enzyme activity to antiv
- Acylcarnitine analogues as topical, microbicidal spermicides.
- Bioorg Med Chem Lett. 1999 Sep 6;9(17):2545-8. Unique Identifier : AIDSLINE MED/99426493
- Savle PS; Doncel GF; Bryant SD; Hubieki MP; Robinette RG; Gandour RD; Department of Chemistry, Virginia Tech, Blacksburg 24061-0212,; USA.
- Acylcarnitine analogues, (+)-6-Carboxylatomethyl-2-alkyl-4,4-dimethylmorpholinium (Z-n, where n = the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing
- Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.
- Unique Identifier : AIDSLINE MED/99426495 P P
- N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.
- Unique Identifier : AIDSLINE MED/99437622
- Uckun FM; Mao C; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Venkatachalam TK
- We have replaced the pyridyl ring of trovirdine with an alicyclic cyclohexenyl, adamantyl or cis-myrtanyl ring. Only the cyclohexenyl-containing thiourea compound N-[2-(1-cyclohexenyl)ethyl]-N -[2-(5-bromopyridyl)]- thiourea (HI-346) (as well as its chlorine-substituted derivative N-[2-(1-cyclohexenyl)ethyl]-N -[2-(5-
- Molecular bases for the anti-HIV-1 effect of NO. Commentary.
- Int J Mol Med. 1999 Oct;4(4):365-8. Unique Identifier : AIDSLINE MED/99425448
- Persichini T; Ascenzi P; Colizzi V; Fraziano M; Venturini G; Colasanti M; Department of Biology, University of Rome , I-00146; Rome, Italy.
- In infected human cells, nitric oxide (NO) has been shown to inhibit the replication of the human immunodeficiency virus-1 (HIV-1), the etiological agent of AIDS. Evidence suggests that NO may regulate HIV-1 replication by affecting the sulphydryl redox state. In this respect, it has been very recently demonstrated th
- Serological diagnosis of human immuno-deficiency virus in Burkina Faso: reliable, practical strategies using less expensive commercial test kits.
- Bull World Health Organ. 1999;77(9):731-9. Unique Identifier : AIDSLINE MED/20004796
- Meda N; Gautier-Charpentier L; Soudre RB; Dahourou H; Ouedraogo-Traore R; Ouangre A; Bambara A; Kpozehouen A; Sanou H; Valea D; Ky F; Cartoux M; Barin F; Van de Perre P; Centre MURAZ/Organisation de Coordination et de Cooperation pour; la lutte contre les Grandes Endemies (OCCGE), Burkina Faso.; nmeda.muraz@fasonet.bf
- Reported are the results of a cross-sectional survey in Burkina Faso to identify reliable, practical strategies for the serological diagnosis of HIV-1 and/or HIV-2 infections, using less-expensive commercial test kits in various combinations, as an alternative to the conventional
- Integrating reproductive health: myth and ideology.
- Bull World Health Organ. 1999;77(9):771-7. Unique Identifier : AIDSLINE MED/20004802
- Lush L; Cleland J; Walt G; Mayhew S; Department of Epidemiology and Population Health, London School; of Hygiene and Tropical Medicine, England.
- Since 1994, integrating human immunodeficiency virus/sexually transmitted disease (HIV/STD) services with primary health care, as part of reproductive health, has been advocated to address two major public health problems: to control the spread of HIV; and to improve women s reproductive health. However, integration i
- Cost-effective HIV treatment for developing countries [news]
- Bull World Health Organ. 1999;77(9):780. Unique Identifier : AIDSLINE MED/20004804
- Proliferative and regenerative capacities of CD4(+) T cells upon TCR stimulation.
- Clin Immunol. 1999 Oct;93(1):16-23. Unique Identifier : AIDSLINE MED/99428743
- Liu Z; Wong JT; Department of Pathology, Massachusetts General Hospital and; Harvard Medical School, Boston, Massachusetts, 02114, USA.
- Proliferation of activated CD4(+) T cells effectively amplifies the immune response. Based on a model of selective CD4(+) T cell proliferation using an anti-CD3:anti-CD8 bispecific monoclonal antibody that leads to selective proliferation of CD4(+) T cells, we demonstrated that the peripheral CD4(+) T cells of normal
- Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy.
- Clin Immunol. 1999 Oct;93(1):24-33. Unique Identifier : AIDSLINE MED/99428744
- Chavan SJ; Tamma SL; Kaplan M; Gersten M; Pahwa SG; Department of Pediatrics, NYU School of Medicine, Manhasset, New; York, 11030, USA.
- Patients with HIV infection manifest increased T lymphocyte apoptosis. This study investigated the influence of antiretroviral therapy (ART) upon lymphocyte apoptosis in 23 HIV-infected adults naive to protease inhibitors . Patients were enrolled in a treatment trial
- Cytokine regulation of env gene expression of human endogenous retrovirus-R in human vascular endothelial cells.
- Clin Immunol. 1999 Oct;93(1):75-80. Unique Identifier : AIDSLINE MED/99428749
- Katsumata K; Ikeda H; Sato M; Ishizu A; Kawarada Y; Kato H; Wakisaka A; Koike T; Yoshiki T; School of Medicine, Hokkaido University, Kita-15, Nishi-7,; Kita-ku, Sapporo, 060-8638, Japan.
- To determine whether human endogenous retroviruses are implicated in the pathogenesis of inflammatory vascular diseases of unknown etiology, we examined mRNA expression of a human endogenous retrovirus, HERV-R, which has a long open reading frame in the env region, in cultured human vascular endothelial and smooth mus
- Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma.
- Clin Immunol. 1999 Nov;93(2):114-23. Unique Identifier : AIDSLINE MED/99459180
- Widney D; Gundapp G; Said JW; van der Meijden M; Bonavida B; Demidem A; Trevisan C; Taylor J; Detels R; Martinez-Maza O; Department of Microbiology, University of California at Los; Angeles School of Medicine 90095-p647, USA.
- CD27 is a member of the tumor necrosis factor receptor superfamily that is expressed primarily on T cells, as well as on subsets of B cells and NK cells. CD70, which is expressed on activated B and T cells, but not on resting lymphocytes, is a ligand for CD27. Cell surface CD27 can be proteolytically cleaved to produc
- Peptide T blocks GP120/CCR5 chemokine receptor-mediated chemotaxis.
- Clin Immunol. 1999 Nov;93(2):124-31. Unique Identifier : AIDSLINE MED/99459181
- Redwine LS; Pert CB; Rone JD; Nixon R; Vance M; Sandler B; Lumpkin MD; Dieter DJ; Ruff MR; Department of Physiology and Biophysics, Georgetown University; School of Medicine, Washington, DC, 20007, USA.
- We previously reported that certain short gp120 V2 region peptides homologous to vasaoactive intestinal peptide (VIP), such as peptide T, were potent inhibitors of gp120 binding, infectivity, and neurotoxicity. The present study shows that synthetic V2-region-derived peptides have potent intrinsic chemotaxis agonist
- Ocular disease in children with vertically acquired human immunodeficiency virus infection.
- J AAPOS. 1998 Jun;2(3):177-81. Unique Identifier : AIDSLINE MED/20000555
- Livingston PG; Kerr NC; Sullivan JL; University of South Florida, Tampa, USA.
- BACKGROUND: Clinical reports suggest that ocular disease in infants and children vertically infected with human immunodeficiency virus (HIV) is different from that in adults. Pediatric patients with acquired immunodeficiency syndrome (AIDS) and HIV infection are being treated more aggressively and are living longer, b
- HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells.
- J Hum Virol. 1999 Sep-Oct;2(5):261-9. Unique Identifier : AIDSLINE MED/20017894
- Weichold FF; Bryant JL; Pati S; Barabitskaya O; Gallo RC; Reitz MS Jr; Institute of Human Virology, University of Maryland Biotechnology; Institute, Baltimore 21201, USA. weichold@umbi.umd.edu
- OBJECTIVE: Clinical experience with HIV-1 protease inhibitors (PIs) in the treatment of AIDS frequently has shown that increases in CD4+ T-cell counts can be independent of HIV-1 inhibition by these drugs. This disconnection between viral load and CD4 counts led us
- Antiviral chemokines: intracellular life of recombinant C-C chemokine RANTES.
- J Hum Virol. 1999 Sep-Oct;2(5):270-82. Unique Identifier : AIDSLINE MED/20017895
- Owais M; Arya SK; Basic Research Laboratory, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.
- OBJECTIVE: Select C-C and C-X-C chemokines can suppress HIV infection. This is because their receptors are the gateways for HIV-1 entry, determinants of viral tropism and sensitivity. C-C chemokines are most effective against macrophage-tropic viruses, and C-X-C chemokines are most effective against T-tropic viruses.
- Increased CCR5 expression with decreased beta chemokine secretion in Ethiopians: relevance to AIDS in Africa.
- J Hum Virol. 1999 Sep-Oct;2(5):283-9. Unique Identifier : AIDSLINE MED/20017896
- Kalinkovich A; Weisman Z; Leng Q; Borkow G; Stein M; Greenberg Z; Zlotnikov S; Eitan S; Bentwich Z; Ruth Ben-Ari Institute of Clinical Immunology, AIDS Center,; Kaplan Medical Center, Hebrew University Hadassah Medical School,; Rehovot, Israel.
- OBJECTIVE: This study was undertaken to determine the contribution of HIV co-receptors and beta chemokine secretion to the increased susceptibility for human immunodeficiency virus (HIV) infection of peripheral blood mononuclear cells (PBMC) obtained from HIV-seronegative Ethiopian immigrants in
- The reverse transcriptase codon 69 insertion is observed in nucleoside reverse transcriptase inhibitor-experienced HIV-1-infected individuals, including those without prior or concurrent zidovudine therapy.
- J Hum Virol. 1999 Sep-Oct;2(5):290-5. Unique Identifier : AIDSLINE MED/20017897
- Ross L; Johnson M; Graham N; Shaefer M; St. Clair M; Glaxo Wellcome, Inc., Research Triangle Park, North Carlina; 27709, USA. llr8156@glaxaowellcome.com
- OBJECTIVES: This study was undertaken to examine 6-bp insertions following codon 69 in the reverse transcriptase (RT) coding region of human immunodeficiency virus type 1 (HIV-1) mutations in terms of incidence, presence of additional RT mutations, phenotypic drug resistance, HIV-1 RNA levels, and antiretroviral treat
- Human T-lymphotropic virus type I tax polymorphisms in a transmission cohort: no association between sequence variation and disease manifestations.
- J Hum Virol. 1999 Sep-Oct;2(5):308-14. Unique Identifier : AIDSLINE MED/20017899
- Sambor AM; Pombo de Oliveira MS; Farhadi A; Carr JK; Carvalho SM; Blattner WA; Kim JH; Henry M. Jackson Foundation, Rockville, Maryland, USA.
- OBJECTIVE: To determine whether a unique human T-lymphotropic virus type I (HTLV-I) transmission cohort containing multiple disease manifestations could be used to establish a relationship between tax gene sequence and HTLV disease expression. METHODS: DNA was extracted from the peripheral blood mononuclear cells (PBM
- Neoplastic AIDS-associated Kaposi's sarcoma cell line KSY-1 cannot transdifferentiate into capillaries.
- J Hum Virol. 1999 Sep-Oct;2(5):315-7. Unique Identifier : AIDSLINE MED/20017900
- Lunardi-Iskandar Y; Wernert N; Cong TH; Samnang S; Bryant JL; Vandenbunder B; Stehelin D; Institute of Human Virology, Medical Biotechnology Center,; University of Maryland at Baltimore, USA.
- OBJECTIVE: Kaposi s sarcoma (KS) is an acquired immunodeficiency syndrome (AIDS)-defining neoplasm histologically characterized by proliferation of spindle cells, inflammatory cells, and abundant neovascularization. When the malignant cell line KSY-1 derived from an AIDS-KS tumor is transplanted subcutaneously into nu
- Sexually-transmitted diseases and assisted reproduction techniques.
- Clin Exp Obstet Gynecol. 1999;26(2):131-2. Unique Identifier : AIDSLINE MED/99388752
- Diani F; Department of Maternal-Fetal Medicine, University of Verona,; Italy.
- As to the correlation between sexually transmitted diseases (STD) and assisted reproduction techniques (ART) we must consider that it is necessary to collate information and start screening campaigns for all sexually active individuals with the purpose of prevention and early diagnosis of STD which may cause of steril
- Anxiety in patients with cancer and human immunodeficiency virus.
- Semin Clin Neuropsychiatry. 1999 Apr;4(2):114-32. Unique Identifier : AIDSLINE MED/99307705
- Kerrihard T; Breitbart W; Dent R; Strout D; Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
- Physicians who treat patients with cancer or human immunodeficiency virus (HIV) infections frequently encounter the psychological and physical manifestations of anxiety in these populations. This chapter provides a review of the prevalence of anxiety disorders in cancer and HIV patients. The problems in assessment and
- Induction of HIV-1-specific T cell responses by administration of cytokines in late-stage patients receiving highly active anti-retroviral therapy.
- Clin Exp Immunol. 1999 Oct;118(1):78-86. Unique Identifier : AIDSLINE MED/20010028
- Imami N; Hardy GA; Nelson MR; Morris-Jones S; Al-Shahi R; Antonopoulos C; Gazzard B; Gotch FM; Department of Immunology, Imperial College School of Medicine,; Chelsea & Westminster Hospital, London, UK. n.imami@ic.ac.uk
- Highly active anti-retroviral therapy (HAART) is associated with reduction in the morbidity and mortality of patients with advanced HIV-1 disease. The ability of such treatment to improve immune responses against HIV-1 and opportunistic pathogens is variable and limited. Addition of cytokine immunotherapy to this trea
- CCR5 and CXCR4 chemokine receptor expression and beta-chemokine production during early T cell repopulation induced by highly active anti-retroviral therapy.
- Clin Exp Immunol. 1999 Oct;118(1):87-94. Unique Identifier : AIDSLINE MED/20010029
- Giovannetti A; Ensoli F; Mazzetta F; De Cristofaro M; Pierdominici M; Muratori DS; Fiorelli V; Aiuti F; Department of Allergy and Clinical Immunology, University 'La; Sapienza', Rome, Italy.
- Expression of chemokine receptors and beta-chemokine production by peripheral blood mononuclear cells (PBMC) were determined in HIV-1-infected individuals before and after highly active anti-retroviral therapy (HAART) and their relationship to viral load, T cell phenotype and the expression of immunological activation
- A lack of evidence for down-modulation of CD3 zeta expression in colorectal carcinoma and pregnancy using multiple detection methods.
- Clin Exp Immunol. 1999 Nov;118(2):197-204. Unique Identifier : AIDSLINE MED/20009342
- Deakin AM; Singh K; Crowe JS; Ellis JH; Dalgleish A; Leicester RJ; Finlayson CJ; Miles WF; Life PF; Immunopathology Unit, Glaxo Wellcome Medicines Research Centre,; Stevenage, UK.
- Loss of the T cell receptor-associated CD3 zeta chain has been proposed as a possible mechanism of the acquired immunosuppression in both tumour-bearing hosts, and in symptomatic patients with HIV infection. However, other reports suggest that the zeta-chain loss may in part be caused by protease activity of contamina
- Thalidomide analogue CC1069 inhibits development of rat adjuvant arthritis.
- Clin Exp Immunol. 1999 Nov;118(2):315-21. Unique Identifier : AIDSLINE MED/20009360
- Oliver SJ; Freeman SL; Corral LG; Ocampo CJ; Kaplan G; Laboratory of Cellular Physiology and Immunology, The Rockefeller; University, New York, NY 10021, USA.; olivers@rockvax.rockefeller.edu
- The cytokine tumour necrosis factor-alpha (TNF-alpha) has been implicated in the aetiology of rheumatoid arthritis in humans as well as of experimental arthritis in rodents. Thalidomide, and to a greater extent the new thalidomide analogue CC1069, inhibit monocyte TNF-alpha production both in vitro and in vivo. The ai
- Safety and availability of immunoglobulin replacement therapy in relation to potentially transmissable agents. IUIS Committee on Primary Immunodeficiency Disease. International Union of Immunological Societies.
- Clin Exp Immunol. 1999 Oct;118 Suppl 1:29-34. Unique Identifier : AIDSLINE MED/20009339
- Chapel HM
- The discovery of two new divergent STLVs has implications for the evolution and epidemiology of HTLVs.
- Rev Med Virol. 1999 Jul;9(3):155-70. Unique Identifier : AIDSLINE MED/99410739
- Van Brussel M; Salemi M; Liu HF; Goubau P; Desmyter J; Vandamme AM; Rega Institute for Medical Research and University Hospitals,; Leuven, Belgium.
- We have isolated and characterised two divergent simian T-lymphotropic viruses (STLV), not belonging to the established human and simian T-lymphotropic virus lineages HTLV-1/STLV-1 and HTLV-2. STLV-L, from an Eritrean sacred baboon (Papio hamadryas), has been typed as a third type of simian T-lymphotropic virus, disti
- European CPMP gives positive opinion on lamivudine for chronic hepatitis B.
- Rev Med Virol. 1999 Jul;9(3):211. Unique Identifier : AIDSLINE MED/99410742
- Fiddian AP; Royal Free University College Medical School, London, UK.; paul.fiddian@which.net
- [Perspectives and hopes in infectious pathology]
- J Soc Biol. 1999;193(3):307-9. Unique Identifier : AIDSLINE MED/20010675
- Ramuz M; Unite INSERM 431, Faculte de Medecine, Nimes.; docallaghan@zeus.sc.univ-montp1.fr
- Over the last few decades, changes in socio-economic conditions and social practices as well as aggressive therapy of many diseases have led to the emergence of new infectious pathologies. These new pathologies are either associated with newly identified microbial species or the emergence of known microbes which have
- [Molecular dialogue between human retroviruses and host cells]
- J Soc Biol. 1999;193(3):317-24. Unique Identifier : AIDSLINE MED/20010677
- Devaux CA; Laboratoire Infections Retrovirales et Signalisation Cellulaire; CRBM-CNRS UPR1086, Faculte de Medecine, Montpellier.; devaux@crbm.cnrs-mop.fr
- Several exogenous retroviruses are etiologic agents of severe human diseases. Retrovirus replication depends on a plethora of highly specific interactions with the host cell resulting in the subversion of multiple cellular signal transduction pathways. Understanding the molecular cross-talk that regulates the relation
- Testing for HIV among patients with tuberculosis in Montreal.
- Clin Invest Med. 1999 Jun;22(3):111-8. Unique Identifier : AIDSLINE MED/99339022
- Geduld J; Brassard P; Culman K; Tannenbaum TN; Graduate Department of Community Health, University of Toronto,; Ont.
- OBJECTIVE: To determine the rate of HIV testing among patients with tuberculosis (TB) in Montreal, and to identify patient characteristics associated with physician screening patterns. Knowledge of local patterns of HIV testing among patients with TB could be used to facilitate the development of strategies to improve
- [A case of AIDS-associated primary CNS lymphoma difficult to differentiate from toxoplasmic encephalitis by clinical symptoms, neuroimages, and therapeutic responses]
- Rinsho Shinkeigaku. 1999 Jun;39(6):665-9. Unique Identifier : AIDSLINE MED/99432613
- Tomiyasu K; Imai A; Yoshida R; Nakazawa K; Yamazaki K; Department of Neurology, Saiseikai Utsunomiya Hospital.
- We reported a 24-year-old Thai woman who developed primary CNS lymphoma (PCNSL) associated with acquired immunodeficency syndrome. It was difficult to distinguish PCNSL from toxoplamic encephalitis in this case by clinical symptoms, findings of CT and MRI, and therapeutic responses
- Culture positive tuberculous meningitis: clinical indicators of poor prognosis.
- Clin Neurol Neurosurg. 1999 Sep;101(3):157-60. Unique Identifier : AIDSLINE MED/20005292
- Tan EK; Chee MW; Chan LL; Lee YL; Department of Neurology, Singapore General Hospital, Singapore.; ek12@aol.com
- Few studies have evaluated culture positive tuberculous meningitis (TBM) as a group. We evaluated certain clinical factors in culture positive TBM which could be associated with a poorer outcome. Out of 40 consecutive TBM patients seen over a period of 4 years in a tertiary referral hospital, 18 culture positive and n
- Nitric oxide modulates HIV-1 replication.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):1-9. Unique Identifier : AIDSLINE MED/20001708
- Mannick JB; Stamler JS; Teng E; Simpson N; Lawrence J; Jordan J; Finberg RW; Department of Adult Oncology, Dana Farber Cancer Institute,; Brigham and Women's Hospital and Harvard Medical School, Boston,; Massachusetts 02115, USA. Joan_Mannick@dfci.harvard.edu
- Although nitric oxide (NO) production is increased in HIV-1-infected patients, and NO is known to inhibit the replication of several viruses, very little is known about the effects of NO on HIV-1 replication. In the present studies, we find that S-nitrosothiols (RSNOs), a class of NO donor compounds present in the hum
- Frontal lobe neuronal injury correlates to altered function in FIV-infected cats.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):10-8. Unique Identifier : AIDSLINE MED/20001709
- Podell M; Maruyama K; Smith M; Hayes KA; Buck WR; Ruehlmann DS; Mathes LE; Department of Veterinary Clinical Sciences, The Ohio State; University, Columbus 43210, USA.
- Six cats infected intravenously at 8 weeks of age with feline immunodeficiency virus Maryland isolate (FIV-MD), were evaluated at 8 and 14 months of age (6 months and 12 months postinfection, respectively) with high spatial resolution proton magnetic resonance spectroscopy (MRS) of the frontal cortex. Two separate con
- Evidence of stavudine-related phenotypic resistance among zidovudine-pretreated HIV-1-infected subjects receiving a therapeutic regimen of stavudine plus lamivudine [letter]
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):101-3. Unique Identifier : AIDSLINE +
- Milazzo L; Rusconi S; Testa L; La Seta-Catamancio S; Galazzi M; Kurtagic S; Citterio P; Gianotto M; Grassini A; Adorni F; d'Arminio-Monforte A; Galli M; Moroni M
- Once-daily administration of didanosine in combination with stavudine in antiretroviral-naive patients. The STADI Group [letter]
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):103-5. Unique Identifier : AIDSLINE MED/20001721
- Reynes J; Denisi R; Massip P; Izopet J; Pellegrin I; Segondy M
- Oral thrush and HIV protease inhibitors [letter]
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):105-6. Unique Identifier : AIDSLINE MED/20001722
- Stricker RB; Goldberg B
- HIV-1-specific cytolytic T-lymphocyte activity correlates with lower viral load, higher CD4 count, and CD8+CD38-DR- phenotype: comparison of statistical methods for measurement.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):19-30. Unique Identifier : AIDSLINE MED/20001710
- Lubaki NM; Shepherd ME; Brookmeyer RS; Hon H; Quinn TC; Kashamuka M; Johnson M; Gottle R; Devers J; Lederman HM; Bollinger RC; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.
- OBJECTIVES: The objective of this study was to use novel statistical methods to determine the correlation between HIV-1-specific cytolytic T-lymphocyte (CTL) activity and HIV-1 plasma viral load, in a blinded study of HIV-infected patients at various stages of clinical disease. METHODS: Peripheral blood mononuclear ce
- Acute activation of CD8+ T lymphocytes in interleukin-2-treated HIV-infected patients. ANRS-048 IL-2 Study Group. Agence Nationale de Recherches sur le SIDA.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):31-8. Unique Identifier : AIDSLINE MED/20001711
- Zou W; Foussat A; Capitant C; Durand-Gasselin I; Bouchet L; Galanaud P; Levy Y; Emilie D; INSERM U131 and Service de Medecine Interne et d'Immunologie; Clinique, Institut Paris-Sud sur les Cytokines, Hopital Antoine; Beclere, Clamart, France.
- CD8+ T lymphocytes play a key role in the control of HIV infection, through both cytotoxic and noncytotoxic mechanisms. To study in vivo effects of interleukin-2 ( IL-2 ) treatment on this cell compartment, the level of activation of CD8+ T lymphocytes was evaluated befo
- Safety and antiretroviral effects of combined didanosine and stavudine therapy in HIV-infected individuals with CD4 counts of 200 to 500 cells/mm3.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):39-48. Unique Identifier : AIDSLINE MED/20001712
- Pollard RB; Peterson D; Hardy D; Pottage J; Murphy RL; Gathe J; Beall G; Rutkievicz V; Reynolds L; Cross AP; Dunkle LM; The University of Texas Medical Branch at Galveston, 77555, USA.
- The safety and antiretroviral effects of didanosine and stavudine in combination were evaluated in 86 people infected with HIV with CD4 counts between 200 and 500 cells/mm3 who had received
- Insulin-like growth factor system in patients with HIV infection: effect of exogenous growth hormone administration.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):49-55. Unique Identifier : AIDSLINE MED/20001713
- Mynarcik DC; Frost RA; Lang CH; DeCristofaro K; McNurlan MA; Garlick PJ; Steigbigel RT; Fuhrer J; Ahnn S; Gelato MC; Department of Medicine, State University of New York at Stony; Brook, 11794-8154, USA.
- The purpose of this study was to characterize changes in the levels of insulin-like growth factor-I (IGF-I) and IGF binding proteins (BP) 1, 2, and 3 in HIV-infected adults throughout the course of their disease, and to assess the responsiveness of the IGF system components to growth hormone (GH) administration (6 mg/
- Randomized, placebo-controlled trial of Chinese herb therapy for HIV-1-infected individuals.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):56-64. Unique Identifier : AIDSLINE MED/20001714
- Weber R; Christen L; Loy M; Schaller S; Christen S; Joyce CR; Ledermann U; Ledergerber B; Cone R; Luthy R; Cohen MR; Department of Internal Medicine, University Hospital, Zurich,; Switzerland. infweb@usz.unizh.ch
- CONTEXT: Alternative medicine or complementary remedies that have not been scientifically tested are nonetheless widely used to treat chronic illnesses, particularly if curative options are limited. OBJECTIVES: To assess the effectiveness of Chinese medicinal herbs in reducing symptoms and improving the quality of lif
- Temporal changes in the rate of progression to death among Italians with known date of HIV seroconversion: estimates of the population effect of treatment. Italian HIV Seroconversion Study (ISS).
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):65-70. Unique Identifier : AIDSLINE MED/20001715
- Dorrucci M; Balducci M; Pezzotti P; Sinicco A; Alberici F; Rezza G; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome,; Italy.
- OBJECTIVE: To evaluate changes in survival among HIV-positive individuals with known date of seroconversion (SC). DESIGN: Prospective cohort study. METHODS: Follow-up lasted from SC to death or to the end of 1997. A multivariate Cox model was applied to estimate relative hazards (RH) of death. The year of SC (as a cat
- Unreported AIDS-defining opportunistic illnesses in persons reported with HIV-related severe immunosuppression.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):71-4. Unique Identifier : AIDSLINE MED/20001716
- Lobato MN; Klevens RM; Li J; Slutsker L; Fleming PL; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.
- To better estimate the distribution of AIDS cases after the 1993 change in the case definition, we assessed the proportion of persons whose AIDS diagnosis was based on laboratory criteria for severe immunosuppression (CD4 count
- Phenotypic expressions of CCR5-delta32/delta32 homozygosity.
- Unique Identifier : AIDSLINE MED/20001717
- Nguyen GT; Carrington M; Beeler JA; Dean M; Aledort LM; Blatt PM; Cohen AR; DiMichele D; Eyster ME; Kessler CM; Konkle B; Leissinger C; Luban N; O'Brien SJ; Goedert JJ; O'Brien TR; Viral Epidemiology Branch, National Cancer Institute, U.S.; Department of Health and Human Services, Rockville, Maryland; 20852, USA.
- OBJECTIVE: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-delta32/delta32 homozygous genotype has phenotypic expressions other than those related to HIV-1. DESIGN: Study subjects were white homosexual men or men with hemophilia who were not infected w
- Similarities and differences by race/ethnicity in changes of HIV seroprevalence and related behaviors among drug injectors in New York City, 1991-1996.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):83-91. Unique Identifier : AIDSLINE MED/20001718
- Friedman SR; Chapman TF; Perlis TE; Rockwell R; Paone D; Sotheran JL; Des Jarlais DC; National Development and Research Institutes, Inc., New York, New; York 10048, USA. sam.friedman@ndri.org
- OBJECTIVE: To measure differences and similarities in the prevalence of HIV infection and of related risk and protective behaviors among New York City black, white, and Hispanic drug injectors during a period of decreasing HIV prevalence. METHODS: Drug injectors were interviewed at a drug detoxification clinic and a r
- Prospective study of HTLV-I infection in an initially asymptomatic cohort.
- J Acquir Immune Defic Syndr. 1999 Sep 1;22(1):92-100. Unique Identifier : AIDSLINE MED/20001719
- Taylor GP; Tosswill JH; Matutes E; Daenke S; Hall S; Bain BJ; Davis R; Thomas D; Rossor M; Bangham CR; Weber JN; Clinical Trials Centre, Imperial College School of Medicine, St.; Mary's Hospital, London, UK. g.p.taylor@ic.ac.uk
- A prospective clinical study of 20 initially asymptomatic HTLV-I-seropositive carriers was commenced in 1991 to determine the natural history of the infection in relation to HTLV-I proviral load, immune responses, and lymphocyte phenotype. Proviral load varied widely between carriers but was relatively constant within
- Pharmacokinetic factors in the modern drug treatment of tuberculosis.
- Unique Identifier : AIDSLINE MED/99424620
- Douglas JG; McLeod MJ; Department of Respiratory Medicine, Aberdeen Royal Infirmary,; Scotland. j.g.douglas@arh.grampian.scot.nhs.uk
- Tuberculosis is increasing in prevalence throughout the world, particularly in sub-Saharan Africa, Asia and Latin America. This resurgence can partly be attributed to increasing poverty, particularly in developing countries, and the human immunodeficiency virus (HIV) pandemic. However, there is also increasing concern
- Pharmacokinetics of valganciclovir and ganciclovir following multiple oral dosages of valganciclovir in HIV- and CMV-seropositive volunteers.
- Clin Pharmacokinet. 1999 Aug;37(2):167-76. Unique Identifier : AIDSLINE MED/99424622
- Brown F; Banken L; Saywell K; Arum I; Roche Products Ltd, Welwyn Garden City, Hertfordshire, England.; Frances.Brown@Roche.com
- OBJECTIVE: Ganciclovir is commonly used in the treatment of cytomegalovirus ( CMV ) disease in patients who are immunocompromised and for the prevention of CMV disease in solid organ transplant recipients. Owing to limited bioa
- Effects of food on clinical pharmacokinetics.
- Clin Pharmacokinet. 1999 Sep;37(3):213-55. Unique Identifier : AIDSLINE MED/99441590
- Singh BN; Department of Pharmacy and Administrative Sciences, College of; Pharmacy and Allied Health Professions, St John's University,; Jamaica, New York, USA. brahmasingh@hotmail.com
- Food-drug interactions can be associated with alterations in the pharmacokinetic and pharmacodynamic profile of various drugs that may have clinical implications. The various phases in which food may interact with a coadministered drug are: (i) before and during gastrointestinal absorption; (ii) during distribution; (
- A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis.
- Clin Pharmacol Ther. 1999 Sep;66(3):246-57. Unique Identifier : AIDSLINE MED/99439078
- Mould DR; Davis CB; Minthorn EA; Kwok DC; Elliott MJ; Luggen ME; Totoritis MC; Drug Metabolism and Pharmacokinetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, PA 19406, USA.
- Clenoliximab (IDEC-151) is a macaque-human chimeric monoclonal antibody (immunoglobulin G4) specific for the CD4 molecule on the surface of T lymphocytes. It is being studied in patients with rheumatoid arthritis in which T cell activation orchestrates inflammation and tissue damage. In this initial study in humans, t
- Intention-to-treat analysis of anti-HIV therapies and incidence of drug resistance after a year of treatment.
- Jpn J Infect Dis. 1999 Jun;52(3):129-31. Unique Identifier : AIDSLINE MED/99429008
- Aizawa S; Ida S; Sakai-Hachiya A; Tanaka M; Takahashi Y; Hirabayashi Y; Sugiura W; Kimura S; Oka S; AIDS Clinical Center, International Medical Center of Japan,; Tokyo.
- Outbreak of hepatitis A virus infection among HIV-1 seropositive men who had sex with men.
- Jpn J Infect Dis. 1999 Jun;52(3):131-2. Unique Identifier : AIDSLINE MED/99429009
- Ishida T; Nakamura T; Ajisawa A; Negishi M; Kashiyama T; Takechi A; Iwamoto A; Department of Infectious Diseases, University of Tokyo.
- Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation.
- Clin Rheumatol. 1999;18(5):394-401. Unique Identifier : AIDSLINE MED/99452185
- Fraser DA; Thoen J; Reseland JE; Forre O; Kjeldsen-Kragh J; Centre for Rheumatic Diseases, National Hospital, Oslo, Norway.; david.fraser@klinmed.uio.no
- We investigated the effects of acute starvation on mitogen-induced T-cell activation and Th1/Th2 cytokine responses in rheumatoid arthritis (RA) patients. Ten RA patients with active disease underwent a 7-day fast followed by a 2-week refeeding period. Immunological, hormonal, laboratory and clinical evaluations were
- Low-dose cyclosporin for multiple colonic ulcers associated with mixed connective tissue disease.
- Clin Rheumatol. 1999;18(5):410-3. Unique Identifier : AIDSLINE MED/99452188
- Maeda N; Abe S; Yoshizawa T; Ogawa K; Sekigawa I; Iida N; Eguchi M; Matsumoto M; Hashimoto H; Hirose S; Department of Medicine, Juntendo University Izu-Nagaoka Hospital,; Shizuoka, Japan.
- This report describes a patient with multiple colonic ulcers and mixed connective tissue disease. The histological findings of the colonic lesions showed vasculitis with T-cell infiltration, and the peripheral T cells were frequently in the activated phase of the cell cycle. In this patient, low-dose cyclosporin treat
- Testing pregnant women for HIV: a survey of obstetricians and review of patient prenatal/obstetric medical records--Connecticut 1996-1997.
- Conn Med. 1999 Sep;63(9):523-9. Unique Identifier : AIDSLINE MED/20000697
- Roome A; Carley K; Melchreit R; Foye G; Hadler J; Connecticut Department of Public Health, Hartford, USA.
- High rates of prenatal testing are needed to identify all HIV-infected pregnant women and prevent transmission to their offspring. To evaluate HIV testing of pregnant women in Connecticut, a survey was conducted in 1998 of licensed obstetricians and a review was performed of 992 randomly sampled prenatal and obstetric
- WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity.
- Contraception. 1999 May;59(5):319-31. Unique Identifier : AIDSLINE MED/99424273
- D'Cruz OJ; Zhu Z; Yiv SH; Chen CL; Waurzyniak B; Uckun FM; Department of Reproductive Biology, Hughes Institute, St. Paul,; Minnesota 55113, USA. odcruz@ih.org
- Heterosexual transmission of HIV to women is the fastest-growing mode of transmission. In a systematic effort to develop a microbicide capable of preventing HIV transmission as well as providing fertility control, novel phenyl phosphate derivatives of 3 -azido-3 -deoxythymidine (zidovudine, ZDV) have been identified t
- The effect of one injection of Depo-Provera on the human vaginal epithelium and cervical ectopy.
- Contraception. 1999 Jul;60(1):15-24. Unique Identifier : AIDSLINE MED/20017214
- Mauck CK; Callahan MM; Baker J; Arbogast K; Veazey R; Stock R; Pan Z; Morrison CS; Chen-Mok M; Archer DF; Gabelnick HL; Contraceptive Research and Development Program (CONRAD),; Arlington, Virginia 22209, USA.
- Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera and Norplant, were associated with vaginal thinning. Progesterone implants have also been associated with an increased risk of simian immunodeficiency virus (SIV) acquisition. This study in 16 women was done to assess vaginal epithelial
- "One people, one blood": public health, political violence, and HIV in an Ethiopian-Israeli setting.
- Cult Med Psychiatry. 1999 Jun;23(2):159-95. Unique Identifier : AIDSLINE MED/99381108
- Seeman D; Department of Sociology and Anthropology, Hebrew University of; Jerusalem, Israel. 103061.123@compuserve.com
- Between 1984 and 1996, public health authorities in Israel maintained a secret policy of discarding blood donations made by Ethiopian-Israeli citizens and immigrants. Officials later attempted to justify this policy on the grounds that immigrants from Ethiopia were subject to high
- Recognition and management of neonates at risk for perinatally acquired infection with human immunodeficiency virus.
- Crit Care Nurse. 1998 Aug;18(4):74-85. Unique Identifier : AIDSLINE MED/99031733
- Franck LS; Johnson LM; School of Nursing, University of California, San Francisco, USA.
- Bronchiectasis in systemic diseases.
- Chest. 1999 Oct;116(4):1063-74. Unique Identifier : AIDSLINE MED/20003207
- Cohen M; Sahn SA; Division of Pulmonary and Critical Care Medicine, Allergy and; Clinical Immunology, Medical University of South Carolina,; Charleston, SC.
- An HIV-infected patient with pleural effusion.
- Chest. 1999 Oct;116(4):1113-5. Unique Identifier : AIDSLINE MED/20003214
- Ibrahimbacha A; Farah M; Saluja J; Division of Pulmonary Medicine, Department of Medicine, St.; Barnabas Hospital, Cornell University Medical Center, Bronx, NY; 10457-2594, USA.
- Propofol containing sulfite-potential for injury [letter]
- Chest. 1999 Oct;116(4):1140-1. Unique Identifier : AIDSLINE MED/20003227
- Langevin PB
- Predicting active pulmonary tuberculosis using an artificial neural network.
- Chest. 1999 Oct;116(4):968-73. Unique Identifier : AIDSLINE MED/20003194
- El-Solh AA; Hsiao CB; Goodnough S; Serghani J; Grant BJ; Department of Medicine, Erie County Medical Center, Buffalo, NY; 14215, USA. solh@buffalo.edu
- BACKGROUND: Nosocomial outbreaks of tuberculosis (TB) have been attributed to unrecognized pulmonary TB. Accurate assessment in identifying index cases of active TB is essential in preventing transmission of the disease. OBJECTIVES: To develop an artificial neural network using clinical and radiographic information to
- Comparison of multiple assays for kinetic detection of apoptosis in thymocytes exposed to dexamethasone or diethylstilbesterol.
- Cytometry. 1999 Jan 1;35(1):80-90. Unique Identifier : AIDSLINE MED/20019612
- Donner KJ; Becker KM; Hissong BD; Ahmed SA; Center for Molecular Medicine and Infectious Diseases, Department; of Biomedical Sciences and Pathobiology, Virginia-Maryland; Regional College of Veterinary Medicine, Virginia Polytechnic; Institute and State University, Blacksburg 24061, USA.
- BACKGROUND: Techniques to measure apoptosis are used to study a wide spectrum of conditions, from acquired immune deficiency syndrome (AIDS) to cancer to autoimmune diseases. Therefore, a critical comparison of common assays for apoptosis is warranted. METHODS: The kinetics of apoptosis induction in dexamethasone (DEX
- Biosafety considerations for flow cytometric analysis of human immunodeficiency virus-infected samples.
- Cytometry. 1999 Oct 15;38(5):195-200. Unique Identifier : AIDSLINE MED/99447589
- Schmid I; Kunkl A; Nicholson JK; Department of Hematology and Oncology, University of California; at Los Angeles, Los Angeles, California. schmid@mednet.ucla.edu
- Enumeration of CD4(+) T-cells in the peripheral blood of HIV-infected patients: an interlaboratory study of the FACSCount system.
- Cytometry. 1999 Oct 15;38(5):231-7. Unique Identifier : AIDSLINE MED/99447593
- Lopez A; Caragol I; Candeias J; Villamor N; Echaniz P; Ortuno F; Sempere A; Strauss K; Orfao A; Servicio General de Citometria, and Departamento de Medicina,; Universidad de Salamanca, Spain.
- The aim of the present study was to assess the interlaboratory reproducibility of the FACSCount system for the enumeration of peripheral blood (PB) CD4(+) T-cells. In each of the seven participating centers, both previously stained and unstained PB samples (n = 49) were received and either analyzed or stained and then
- Expression of CD134 (0X-40) on T cells during the first 100 days following allogeneic bone marrow transplantation as a marker for lymphocyte activation and therapy-resistant graft-versus-host disease.
- Cytometry. 1999 Oct 15;38(5):238-43. Unique Identifier : AIDSLINE MED/99447594
- Lamb LS Jr; Abhyankar SA; Hazlett L; O'Neal W; Folk RS; Vogt S; Parrish RS; Bridges K; Henslee-Downey PJ; Gee AP; Division of Transplantation Medicine, Palmetto Richland Memorial; Hospital, Center for Cancer Treatment and Research, University of; South Carolina School of Medicine, Columbia, South Carolina.; lslamb@compuserve.com
- CD134 (OX-40) is an activation-associated antigen which functions as a costimulatory receptor for CD4+ T cells. In order to determine the expression of CD134 during immune recovery following allogeneic bone marrow transplantation (BMT), we measured its expression on T cells and T cell subsets during the first 100 days
- Mitogen-induced T-cell CD69 expression is a less sensitive measure of T-cell function than [(3)H]-thymidine uptake.
- Cytometry. 1999 Oct 15;38(5):244-9. Unique Identifier : AIDSLINE MED/99447595
- Hutchinson P; Divola LA; Holdsworth SR; Department of Clinical Immunology, Monash Medical Centre,; Melbourne, Australia.
- The most widely used in vitro measure of T-cell function has been the assessment of mitogen induced proliferation by [(3)H]-thymidine incorporation. Mitogens also induce T-cell surface expression of a number of molecules associated with activation, including CD69. Recent reports have suggested that flow cytometric ana
- Vertically transmitted enteroviruses and the benefits of neonatal immunization [letter]
- Diabetes Care. 1999 Oct;22(10):1760-1. Unique Identifier : AIDSLINE MED/99455683
- Classen JB; Classen DC
- Utility of fine-needle aspiration in the diagnosis of salivary gland lesions in patients infected with human immunodeficiency virus.
- Diagn Cytopathol. 1999 Oct;21(4):260-4. Unique Identifier : AIDSLINE MED/99425228
- Chhieng DC; Argosino R; McKenna BJ; Cangiarella JF; Cohen JM; Department of Pathology, New York University Medical Center, New; York, New York 10016, USA.
- Fine-needle aspiration (FNA) has been increasingly utilized as a diagnostic tool in evaluating salivary gland masses, primarily to differentiate nonneoplastic from neoplastic lesions. Patients infected with human immunodeficiency virus (HIV) frequently present with salivary gland lesions. In this study, we reviewed th
- 2'-beta-fluoro-2',3'-dideoxyadenosine, lodenosine, in rhesus monkeys: plasma and cerebrospinal fluid pharmacokinetics and urinary disposition.
- Drug Metab Dispos. 1999 Oct;27(10):1128-32. Unique Identifier : AIDSLINE MED/99428409
- Roth JS; McCully CM; Balis FM; Poplack DG; Kelley JA; Laboratory of Medicinal Chemistry, Division of Basic Sciences,; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892, USA. rothj@dc37a.nci.nih.gov
- 2 -beta-Fluoro-2 ,3 -dideoxyadenosine (F-ddA, lodenosine) is a nucleoside analog that was rationally designed as a more chemically and enzymatically stable anti-AIDS drug than its parent compound 2 , 3 -dideoxyadenosine or didanosine. Plasma and cerebrospinal fluid (CSF) pharmacokinetics of this compound and its major
- Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction [published erratum appears in Drug Metab Dispos 1999 Nov;27(11):1374]
- Drug Metab Dispos. 1999 Oct;27(10):1187-93. Unique Identifier : AIDSLINE MED/99428417
- Lin JH; Chiba M; Chen IW; Nishime JA; deLuna FA; Yamazaki M; Lin YJ; Drug Metabolism, Merck Research Laboratories, West Point,; Pennsylvania 19486, USA. jiunnvlin@merck.com
- Indinavir , a potent and specific inhibitor of HIV protease, is a known substrate of cytochrome P-450 (CYP) 3A and p-glycoprotein. The purpose of this study is to investigate and compare the inducing effect of dexamethasone (DEX) on CYP3A and p-glycopr
- Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz.
- Unique Identifier : AIDSLINE MED/20004591
- Mutlib AE; Chen H; Nemeth GA; Markwalder JA; Seitz SP; Gan LS; Christ DD; Drug Metabolism and Pharmacokinetics Section, DuPont; Pharmaceuticals Company, Stine-Haskell Research Center, Newark,; Delaware 19714, USA. abdul.mutlib@dupontpharma.com
- Efavirenz ( Sustiva , Fig. 1) is a potent and specific inhibitor of HIV-1 reverse transcriptase approved for the treatment of HIV infection. To examine the potential differences in the
- Needle exchange program participation by anabolic steroid injectors, United States 1998.
- Drug Alcohol Depend. 1999 Sep 1;56(2):157-60. Unique Identifier : AIDSLINE MED/99410132
- Rich JD; Foisie CK; Towe CW; Dickinson BP; McKenzie M; Salas CM; The Miriam Hospital and Brown University, Providence, Rhode; Island, USA. josiah_rich@brown.edu
- A significant number of people are currently misusing and abusing anabolic steroids. Hepatitis B, C, and HIV have all been documented to occur among anabolic steroid injectors (ASIs), most likely from the sharing of injection equipment. A survey was administered to 42 needle exchange programs (NEPs) from 17 states in
- [Why physicians refuse to treat HIV patients (news)]
- Dtsch Med Wochenschr. 1999 Oct 8;124(40):A10. Unique Identifier : AIDSLINE MED/20016670
- Appel K
- Cidofovir: a review of its use in cytomegalovirus retinitis in patients with AIDS.
- Drugs. 1999 Aug;58(2):325-45. Unique Identifier : AIDSLINE MED/99400003
- Plosker GL; Noble S; Adis International Limited, Auckland, New Zealand.; demail@adis.co.nz
- Cidofovir is an antiviral nucleotide analogue with significant activity against cytomegalovirus ( CMV ) and other herpesviruses. The drug is indicated for the treatment of CMV retinitis, a sight-threatening condition, in patien
- Adefovir dipivoxil.
- Drugs. 1999 Sep;58(3):479-87; discussion 488-9. Unique Identifier : AIDSLINE MED/99421018
- Noble S; Goa KL; Adis International Limited, Mairangi Bay, Auckland, New Zealand.; demail@adis.co.nz
- Adefovir dipivoxil is an ester prodrug of the nucleoside reverse transcriptase inhibitor adefovir (PMEA), the prototype compound of the acyclic nucleoside phosphonates. It has better oral bioavailability than the parent compound. Adefovir dipivoxil 120mg once daily significantly reduced viral load compared with placeb
- Prevalence and clinical features of tuberculosis in Ethiopian diabetic patients.
- East Afr Med J. 1999 Jul;76(7):361-4. Unique Identifier : AIDSLINE MED/99450064
- Feleke Y; Abdulkadir J; Aderaye G; Endocrinology and Metabolism Unit, Addis Ababa University,; Ethiopia.
- OBJECTIVE: To determine the prevalence and clinical characteristics of tuberculosis (TB) in diabetic patients. DESIGN: This study was a cross-sectional survey based on the retrospective analysis of data on tuberculosis in diabetic patients. SETTINGS: The study was conducted at Endocrinology and Metabolism Unit of the
- Immunoglobulin profile in HIV-1 infected children in Dar es Salaam.
- East Afr Med J. 1999 Jul;76(7):370-5. Unique Identifier : AIDSLINE MED/99450066
- Lyamuya EF; Matee MI; Kasubi M; Scheutz F; Department of Microbiology and Immunology, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzania.
- OBJECTIVE: To determine immunoglobulin levels in HIV-1 seronegative and HIV-1 seropositive children at different clinical stages of HIV infection. DESIGN: Cross-sectional study. SETTING: Lugalo and Mwanayamala mother and child clinics in Dar es Salaam. SUBJECTS: Two hundred and ninety-nine children aged 18 months to f
- HIV sero-prevalence among tuberculosis patients in Kenya.
- East Afr Med J. 1999 Aug;76(8):452-6. Unique Identifier : AIDSLINE MED/99450054
- Van Gorkom J; Kibuga D; Adallah S; Adungosi J; Aluvaala B; Kangangi J; Kutwa A; Olewe M; Rono P; Wambua M; Royal Netherlands Tuberculosis Association, The Hague,; Netherlands.
- OBJECTIVE: To determine HIV seroprevalence among tuberculosis patients and the burden of HIV attributable tuberculosis among notified patients in Kenya . DESIGN: A cross-sectional anonymous unlinked HIV seroprevalence survey. SETTING: Tuberculosis diagnostic clinics of the National L
- Mutations altering the moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle.
- EMBO J. 1999 Sep 1;18(17):4700-10. Unique Identifier : AIDSLINE MED/99400615
- Yuan B; Li X; Goff SP; Integrated Program in Cellular, Molecular and Biophysical; Studies, Howard Hughes Medical Institute, Department of; Biochemistry, New York, NY 10032, USA.
- The p12 Gag protein of Moloney murine leukemia virus is a small polypeptide of unknown function, containing two proline-rich motifs. To determine its role in replication, we introduced a series of deletion and alanine-scanning substitution mutations throughout the p12 coding region of a proviral DNA, and characterized
- The highly similar TMP kinases of Yersinia pestis and Escherichia coli differ markedly in their AZTMP phosphorylating activity.
- Eur J Biochem. 1999 Oct 1;265(1):112-9. Unique Identifier : AIDSLINE GENBANK/AF065312
- Chenal-Francisque V; Tourneux L; Carniel E; Christova P; Li de la Sierra I; Barzu O; Gilles AM; Laboratoire des Yersinia, Institut Pasteur, Paris, France.
- Thymidine monophosphate (TMP) kinases are key enzymes in nucleotide synthesis for all living organisms. Although eukaryotic and viral TMP kinases have been studied extensively, little is known about their bacterial counterparts. To characterize the TMP kinase of Yersinia pestis, a chromosomal region encompassing its g
- Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.
- Eur J Biochem. 1999 Oct 1;265(1):423-9. Unique Identifier : AIDSLINE MED/99421759
- Tozser J; Bagossi P; Boross P; Louis JM; Majerova E; Oroszlan S; Copeland TD; Department of Biochemistry and Molecular Biology, University; Medical School of Debrecen, Hungary. tozser@indi.biochem.dote.hu
- Vimentin, a cellular substrate of HIV type 1 (HIV-1) proteinase, contains a protein kinase C (PKC) phosphorylation site at one of its cleavage sites. Peptides representing this site were synthesized in P2 Ser-phosphorylated and nonphosphorylated forms. While the nonphosphorylated peptide was a fairly good substrate of
- Mapping of the interaction between the immunodominant loop of the ectodomain of HIV-1 gp41 and human complement protein C1q.
- Eur J Biochem. 1999 Oct;265(2):656-63. Unique Identifier : AIDSLINE MED/99435980
- Quinkal I; Hernandez JF; Chevallier S; Arlaud GJ; Vernet T; Laboratoire d'Ingenierie des Macromolecules, Institut de; Biologie Structurale Jean-Pierre Ebel, Grenoble, France.
- The human immunodeficiency virus type 1 transmembrane envelope glycoprotein gp41 has been previously shown to activate the C1 complex of human complement through direct interaction with its C1q subunit. The major interaction site has been located within the gp41 immunodominant region (residues 590-620), and a syntheti
- Mycobacterium kansasii infection in patients infected with the human immunodeficiency virus.
- Eur J Clin Microbiol Infect Dis. 1999 Aug;18(8):582-6. Unique Identifier : AIDSLINE MED/99444784
- Pintado V; Gomez-Mampaso E; Martin-Davila P; Cobo J; Navas E; Quereda C; Fortun J; Guerrero A; Department of Infectious Diseases, Hospital Ramon y Cajal,; Madrid, Spain.
- To investigate the clinical and radiographic features and the response to therapy of Mycobacterium kansasii infection in human immunodeficiency virus-infected patients, the clinical charts of 19 cases diagnosed during a 15-year period were reviewed retrospectively. Most patients were male intravenous drug abusers. Myc
- New lineal immunoenzymatic assay for simultaneous detection of p24 antigen and HIV antibodies.
- Eur J Clin Microbiol Infect Dis. 1999 Aug;18(8):591-4. Unique Identifier : AIDSLINE MED/99444786
- Martinez-Martinez P; Martin del Barrio E; De Benito J; Landinez R; Department of Microbiology, University Hospital of Valladolid,; Spain.
- The aim of this study was to evaluate a new lineal immunoenzymatic assay for the simultaneous detection of HIV-1/HIV-2 antibodies and p24 antigen. A total of 320 serum samples were obtained from individuals infected by HIV (HIV 1, n = 183; HIV 2, n = 2), individuals with risk factors for HIV infection (n =49), recipie
- Association between submaximal suppression of HIV replication and use of drug combinations without protease inhibitors.
- Eur J Clin Microbiol Infect Dis. 1999 Aug;18(8):604-5. Unique Identifier : AIDSLINE MED/99444791
- de Mendoza C; Soriano V; Gonzalez-Lahoz J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- Cytomegalovirus polyradiculopathy presenting as bilateral radial nerve palsies in a patient with AIDS.
- Eur J Clin Microbiol Infect Dis. 1999 Aug;18(8):605-6. Unique Identifier : AIDSLINE MED/99444792
- Reus S; Boix V; Priego M; Merino E; Portilla J; Unidad de Enfermedades Infecciosas, Hospital General; Universitario de Alicante, Spain. vboix@san.gva.es
- Usefulness of pp65 antigenemia for the early diagnosis of cytomegalovirus disease in patients with AIDS.
- Eur J Clin Microbiol Infect Dis. 1999 Sep;18(9):630-5. Unique Identifier : AIDSLINE MED/20001751
- Torrus D; Portilla J; Hernandez-Aguado I; Boix V; Plazas J; Gimeno A; Torrome M; Llopis C; Valls V; Sanchez-Paya J; Servicio de Medicina Interna, Seccion de Enfermedades; Infecciosas, Hospital General Universitario de Alicante, Spain.; karmen@umh.es
- An observational cohort study was performed to assess the effectiveness of a cytomegalovirus antigenemia (CMV-Ag) assay designed to predict clinical CMV disease in patients with AIDS. Eighty-six HIV-infected patients with CD4+ cell counts of
- A case of HIV-associated cerebral histoplasmosis successfully treated with fluconazole.
- Eur J Clin Microbiol Infect Dis. 1999 Sep;18(9):658-61. Unique Identifier : AIDSLINE MED/20001756
- Knapp S; Turnherr M; Dekan G; Willinger B; Stingl G; Rieger A; Department of Internal Medicine I, University of Vienna Medical; School, Austria.
- Clinically apparent involvement of the central nervous system is a rare event in cases of disseminated histoplasmosis, even in HIV-infected persons. Despite therapy with amphotericin B, mortality remains very high. Reported here is the case of an HIV-infected patient with a 3-month history of fever, cough, weight loss
- First report of the presence of human T-cell lymphotropic virus I infection in Italian drug addicts.
- Eur J Clin Microbiol Infect Dis. 1999 Sep;18(9):671-2. Unique Identifier : AIDSLINE MED/20001760
- Lillo FB; Capiluppi B; Chiarolini A; McDermott JL; Varnier OE; Laboratory of Virology, IRCCS H San Raffaele, Milan, Italy.
- Diabetes mellitus associated with protease inhibitor use.
- Eur J Clin Microbiol Infect Dis. 1999 Sep;18(9):675-7. Unique Identifier : AIDSLINE MED/20001763
- Rodriguez-Rosado R; Soriano V; Blanco F; Dona C; Gonzalez-Lahoz J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- Anogenital intraepithelial lesions in HIV positive patients. Report of 3 cases with 3-year follow-up.
- Eur J Gynaecol Oncol. 1999;20(4):321-2. Unique Identifier : AIDSLINE MED/99402118
- Makris N; Xygakis A; Sakellaropoulos G; Iatrakis G; Ladopoulos J; Department of Obstetrics & Gynaecology, Mitera Maternity; Hospital, Athens, Greece.
- Three cases of HIV-positive immunocompromised women, complicated by anogenital intraepithelial lesions are presented in the present paper. Two patients, aged 42 and 33, had a combination of cervical intraepithelial neoplasia grade 3 (CIN 3) and anal intraepithelial neoplasia grade 2 (AIN 2). The other one, aged 26, pr
- Circumscribed intestinal protein loss with deficiency in CD4+ lymphocytes after the Fontan procedure.
- Eur J Pediatr. 1999 Oct;158(10):847-50. Unique Identifier : AIDSLINE MED/99415791
- Koch A; Hofbeck M; Feistel H; Buheitel G; Singer H; Department of Nuclear Medicine, Friedrich-Alexander University; Erlangen-Nurnberg, Erlangen, Germany.
- Protein-losing enteropathy is an important complication after right heart bypass operations (Fontan procedure). Laboratory examinations usually reveal hypoalbuminaemia, hypoproteinaemia, elevated alpha(1)-antitrypsin clearance, and lymphocytopenia. A case of protein-losing enteropathy after Fontan procedure is reporte
- The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.
- Eur J Immunol. 1999 Oct;29(10):3210-5. Unique Identifier : AIDSLINE MED/20010058
- Garlisi CG; Xiao H; Tian F; Hedrick JA; Billah MM; Egan RW; Umland SP; Allergy and Immunology, Schering-Plough Research Institute,; Kenilworth 07033-0539, USA. charles.garlisi@spcorp.com
- Identification of chemokine receptors and their associated ligands is crucial to the understanding of most immune reactions. Three human chemokines [I-309, thymus and activation-regulated chemokine (TARC) and macrophage inflammatory protein-1beta (MIP-1beta)] have been reported to be ligands for CC-chemokine receptor
- Homeostatic regulation of CD8+ T cells by perforin.
- Eur J Immunol. 1999 Oct;29(10):3262-72. Unique Identifier : AIDSLINE MED/20010064
- Kagi D; Odermatt B; Mak TW; Ontario Cancer Institute/Amgen Institute Toronto, Canada.; dkagi@amgen.com
- To prevent uncontrolled expansion, the massive proliferation of T cells during an acute immune response has to be followed by controlled deletion. Here we show that similar to Fas, perforin is not only an important effector molecule of cytotoxic T lymphocytes (CTL) but also involved in down-regulating peripheral T cel
- The interplay between T helper subset cytokines and IL-12 in directing human B lymphocyte differentiation.
- Eur J Immunol. 1999 Oct;29(10):3369-79. Unique Identifier : AIDSLINE MED/20010075
- Gagro A; Gordon J; The Medical Research Council Centre for Immune Regulation, The; University of Birmingham, The Medical School, Birmingham, GB.
- This study asks how T helper (TH) subset cytokines impact upon IL-12-directed change in B cells engaged in signaling via the B cell receptor and CD40, essential components in the initiation of T-dependent B cell responses. For B cells stimulated in this way, IL-12 promoted a distinct phenotype highlighted by the hyper
- Combining DNA and protein vaccines for early life immunization against respiratory syncytial virus in mice.
- Eur J Immunol. 1999 Oct;29(10):3390-400. Unique Identifier : AIDSLINE MED/20010077
- Martinez X; Li X; Kovarik J; Klein M; Lambert PH; Siegrist CA; W.H.O. Collaborating Center for Neonatal Vaccinology Departments; of Pathology and Pediatrics, University of Geneva Medical School,; Geneva, Switzerland.
- Early life responses to respiratory syncytial virus (RSV)-F DNA and RSV-F protein immunization were studied in murine models of neonatal immunization. RSV-F DNA induced similar antibody (Ab) responses, antigen-specific IFN-gamma production and cytotoxic T lymphocyte (CTL) responses in 1-week-old and adult BALB / c mic
- IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18.
- Eur J Immunol. 1999 Sep;29(9):2658-65. Unique Identifier : AIDSLINE MED/99438021
- Cai G; Kastelein RA; Hunter CA; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia, PA 19104-6008, USA.
- Previous studies have shown that IL-10 inhibits the accessory cell functions required for production of IFN-gamma by T cells and NK cells. Our results show that although IL-10 did not induce the production of IFN-gamma by NK cells, it did enhance the ability of IL-18 to stimulate NK cell production of IFN-gamma. In ad
- Molecular analysis of HIV-1 gp120 antibody response using isotype IgM and IgG phage display libraries from a long-term non-progressor HIV-1-infected individual.
- Eur J Immunol. 1999 Sep;29(9):2666-75. Unique Identifier : AIDSLINE MED/99438022
- Toran JL; Kremer L; Sanchez-Pulido L; de Alboran IM; del Real G; Llorente M; Valencia A; de Mon MA; Martinez-A C; Department of Immunology and Oncology, Centro Nacional de; Biotecnologia, CSIC/UAM, Campus de Cantoblanco, Madrid, Spain.
- To characterize the variable heavy chain (VH)3 antibody response to HIV-1 gp120, we analyzed a panel of IgM and IgG1 Fab fragments from phage display isotype libraries from a long-term, non-progressor HIV-1-infected individual. The IgM Fab antibodies isolated had low affinity for gp120, were not restricted to a partic
- Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation.
- Eur J Immunol. 1999 Sep;29(9):2705-14. Unique Identifier : AIDSLINE MED/99438026
- Aloisi F; Ria F; Columba-Cabezas S; Hess H; Penna G; Adorini L; Laboratory of Organ and System Pathophysiology, Istituto; Superiore di Sanita, Roma, Italy. fos4@iss.it
- We have compared the efficiency of central nervous system and peripheral antigen-presenting cells (APC) in T cell priming and restimulation. OVA peptide 323 - 339-dependent activation of DO11.10 TCR-transgenic naive CD4+ and polarized Th1 or Th2 cells was assessed in the presence of microglia and astrocytes from the n
- Dendritic cells need T cell help to prime cytotoxic T cell responses to strong antigens.
- Eur J Immunol. 1999 Sep;29(9):2826-34. Unique Identifier : AIDSLINE MED/99438038
- Livingstone AM; Kuhn M; Department of Biology, Imperial College of Science, Technology; and Medicine, London, GB.; alexandra_livingstone@urmc.rochester.edu
- Peptide-pulsed mouse dendritic cells (DC) primed peptide-specific CD8+ cytotoxic T cell responses very effectively if they expressed minor histocompatibility antigens, which could stimulate a CD4+ T helper cell response. These DC could also prime most syngeneic mice, although there was no deliberate immunization for h
- Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms.
- Eur J Immunol. 1999 Sep;29(9):2908-15. Unique Identifier : AIDSLINE MED/99438046
- Kern F; Khatamzas E; Surel I; Frommel C; Reinke P; Waldrop SL; Picker LJ; Volk HD; Institut fur Medizinische Immunologie Charite - Campus Mitte,; Humboldt-Universitat zu Berlin, Berlin, Germany.; florian.kern@charite.de
- Chronic antigenic stimulation has been associated with peripheral blood expansions of CD8pos. T cells characterized by CD57 expression, loss of CD27 expression, and reversal of the CD45RO(bright) /RA(dim) phenotype usually associated with immunological memory towards a CD45RO(dim) /RA(bright) phenotype. However, the r
- An influence of CD5 on the selection of CD4-lineage T cells.
- Eur J Immunol. 1999 Sep;29(9):2916-22. Unique Identifier : AIDSLINE MED/99438047
- Chan S; Waltzinger C; Tarakhovsky A; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et Cellulaire; (CNRS/INSERM/ULP) Illkirch, C.U. de Strasbourg, France.
- Combining CD5-null, MHC-deficient and lineage-specific reporter animals, we have investigated the influence of CD5 on positive selection and the choice of CD4- versus CD8-lineage commitment on broad populations of thymocytes. CD5 has no obvious quantitative effect in wild-type mice. In mice lacking MHC class II molecu
- Lineage-specific differences among CD8+ T cells in their dependence of NF-kappa B/Rel signaling.
- Eur J Immunol. 1999 Sep;29(9):2968-80. Unique Identifier : AIDSLINE MED/99438052
- Mora AL; Chen D; Boothby M; Rubin DH; Department of Microbiology and Immunology, Vanderbilt University,; Nashville, TN 37232-2363, USA.
- Whereas most CD8+ T cells in lymph nodes and spleen express the CD8alpha beta heterodimer and depend absolutely on thymic competence for their development, a substantial population of T cells expressing CD8alpha alpha matures extrathymically. Although the existence of these CD8 sublineages is well established, relativ
- Impact of V beta 8+/+ T cells on the development of increased airway reactivity and IgE production in SJL mice.
- Eur J Immunol. 1999 Sep;29(9):3028-34. Unique Identifier : AIDSLINE MED/99438058
- Herz U; Kammertoens T; Rosenbaum J; da Palma JC; Rimm I; Renz H; Charite Campus Virchow-Clinic Department of Laboratory Medicine; and Pathobiochemistry, Berlin, Germany. Udo.Herz@charite.de
- SJL mice have been extensively characterized as low-responder animals in terms of IgE-dependent immediate-type hypersensitivity responses. Since these mice are genetically deficient in certain TCR Vbeta gene segments, we asked whether this might be the reason for the low-responder status. Specifically in H-2d mice
- Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection.
- Eur J Immunol. 1999 Sep;29(9):3047-50. Unique Identifier : AIDSLINE MED/99438060
- Roberts LJ; Baldwin TM; Speed TP; Handman E; Foote SJ; The Walter and Eliza Hall Institute of Medical Research,; Victoria, Australia.
- As in other infectious diseases, the outcome of a Leishmania major infection is closely tied to the T helper cell response type; progressive disease is associated with a predominant Th2 lymphocyte response, healing with a Th1 response. In mice, susceptibility is genetically con trolled, with BALB/c (C) mice being susc
- Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation.
- Exp Gerontol. 1999 Aug;34(5):633-44. Unique Identifier : AIDSLINE MED/99458372
- Spaulding C; Guo W; Effros RB; Department of Pathology and Laboratory Medicine, University of; California Los Angeles School of Medicine, 90095-1732, USA.
- We have established an in vitro culture model of cellular aging in which antigen-specific T cells are stimulated repeatedly to divide until they reach the irreversible state of growth arrest known as replicative senescence. T lymphocytes that reach replicative senescence in culture show complete loss of CD28 express
- Ganglioside GD1b supresses immunoglobulin production by human peripheral blood mononuclear cells.
- Exp Hematol. 1999 Oct;27(10):1487-93. Unique Identifier : AIDSLINE MED/99445077
- Kanda N; Tamaki K; Department of Dermatology, Faculty of Medicine, University of; Tokyo, Japan. KANDA-DER@hiu-tokyo.ac.jp
- Gangliosides are sialic acid-containing glycolipids, that have various immunomodulatory effects. We previously reported that various gangliosides in vitro either inhibited or enhanced spontaneous immunoglobulin (Ig) production by human peripheral blood mononuclear cells (PBMC). GD1b was one of the inhibitory gangliosi
- Leishmania: naive human T cells sensitized with promastigote antigen and IL-12 develop into potent Th1 and CD8(+) cytotoxic effectors.
- Exp Parasitol. 1999 Nov;93(3):161-70. Unique Identifier : AIDSLINE MED/20002522
- Russo DM; Chakrabarti P; Higgins AY; Department of Microbiology, Meharry Medical College, Nashville,; Tennessee 37208, USA.
- Russo, D. M., Chakrabarti, P., and Higgins, A. Y. 1999. Leishmania: Naive human T cells sensitized with promastigote antigen and IL-12 develop into potent Th1 and CD8(+) cytotoxic effectors. Experimental Parasitology 93, 161-170. The differentiation of naive human T cells into Leishmania-specific Th1 or cytotoxic effe
- Knowledge of HIV serostatus and preventive behaviour among European injecting drug users: second study. European Community Study Group on HIV in Injecting Drug Users.
- Unique Identifier : AIDSLINE MED/99320972
- Schlumberger MG; Desenclos JC; Papaevangelou G; Richardson SC; Ancelle-Park R
- The objective of the study was to analyse the effect of knowledge of HIV serostatus on behaviours preventing the acquisition or transmission of HIV among European IDU, and to compare results with a previous similar study conducted 3 years before. Data were gathered in 1992-1993 during a retrospective multicentre cross
- Low seroprevalence of HTLV-I and HTLV-II in patients with a sexually transmitted disease. Study Group for HTLV and STDs.
- Eur J Epidemiol. 1999 Mar;15(3):225-9. Unique Identifier : AIDSLINE MED/99320974
- Suligoi B; Galli C; Ciuta S; Decker R; Istituto Superiore di Sanita, National AIDS Center, Rome, Italy.; suligoi@iss.it
- To determine the prevalence of HTLV I-II among highly sexually active adults, a seroprevalence study was conducted in Italy between March 1992 and March 1993 among 1506 patients with a newly diagnosed STD. Individuals were tested with an enzyme immunoassay that employs a double vira
- Serum thrombopoietin levels in thrombocytopenic and non-thrombocytopenic patients with human immunodeficiency virus (HIV-1) infection.
- Eur J Haematol. 1999 Oct;63(4):245-50. Unique Identifier : AIDSLINE MED/99457996
- Espanol I; Muniz-Diaz E; Margall N; Rabella N; Sambeat MA; Hernandez A; Pujol-Moix N; Department d'Hematologia, Hospital de la Santa Creu i Sant Pau,; Universitat Autonoma, Barcelona, Spain.
- HIV-1 seropositive patients often exhibit thrombocytopenia, considered of multifactorial aetiology. Thrombopoietin (TPO), a recently isolated cytokine, is the main regulator of megakaryocyte and platelet production. The objective of this study was to analyse serum TPO levels in thrombocytopenic and non-thrombocytopeni
- CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s).
- FEBS Lett. 1999 Oct 8;459(2):195-9. Unique Identifier : AIDSLINE MED/99447642
- Nagata K; Hirai H; Tanaka K; Ogawa K; Aso T; Sugamura K; Nakamura M; Takano S; Research and Development Center, BioMedical Laboratories, Inc.,; 1361-1 Matoba, Kawagoe, Saitama, Japan. nagata@alk.co.jp
- We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T-helper- (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells
- An antigenic HIV-1 peptide sequence engineered into the surface structure of transferrin does not elicit an antibody response.
- FEBS Lett. 1999 Oct 8;459(2):230-2. Unique Identifier : AIDSLINE MED/99447650
- Ali SA; Joao HC; Hammerschmid F; Eder J; Steinkasserer A; Novartis Research Institute, Brunnerstrasse 59, A-1230, Vienna,; Austria.
- One novel approach for the biological delivery of peptide drugs is to incorporate the sequence of the peptide into the structure of a natural transport protein such as human serum transferrin (HST). However, a potential drawback is that the HST may increase the immunoreactivity of the peptide, in the same way that car
- Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients.
- FEBS Lett. 1999 Oct 15;459(3):399-404. Unique Identifier : AIDSLINE MED/99456853
- Asamitsu K; Morishima T; Tsuchie H; Kurimura T; Okamoto T; Department of Molecular Genetics Nagoya City University Medical; School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan.
- The nef gene is considered to play a crucial role in the development of acquired immunodeficiency syndrome (AIDS). In this study, we analyzed the sequence of nef quasispecies obtained from replication-competent HIV-1 isolates from two Japanese hemophiliac patients infected with HIV-1. At least 10 nef clones were isola
- Assisted reproduction for couples infected with the human immunodeficiency virus type 1 [editorial]
- Fertil Steril. 1999 Oct;72(4):592-4. Unique Identifier : AIDSLINE MED/99449402
- Anderson DJ
- The antiviral agents, MAP30 and GAP31, are not toxic to human spermatozoa and may be useful in preventing the sexual transmission of human immunodeficiency virus type 1.
- Fertil Steril. 1999 Oct;72(4):686-90. Unique Identifier : AIDSLINE MED/99449421
- Schreiber CA; Wan L; Sun Y; Lu L; Krey LC; Lee-Huang S; New York University School of Medicine, New York, USA.
- OBJECTIVE: To investigate the effects of two virucidal compounds, MAP30 (Momordica anti-human immunodeficiency virus [HIV] protein; molecular weight, 30 kd) and GAP31 (Gelonium anti-HIV protein; molecular weight, 31 kd), obtained from Momordica charantia and Gelonium multiflorum, respectively, on the motility and vita
- Infectious disease concerns and possible complications in the dental patient.
- Dent Clin North Am. 1999 Jul;43(3):435-56, vi. Unique Identifier : AIDSLINE MED/99446116
- Bordon E; Bordon J; Department of Medicine, Providence Hospital, Washington, District; of Columbia 20017, USA.
- Several questions and concerns often arise in the management of patients with infectious complications. This article explores the difficult issues surrounding the treatment of patients with infectious diseases: infectivity of the present conditions, medication side effects, and potential complications secondary to the
- T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia.
- Eur J Obstet Gynecol Reprod Biol. 1999 Oct;86(2):165-70. Unique Identifier : AIDSLINE MED/99437484
- Darmochwal-Kolarz D; Leszczynska-Gorzelak B; Rolinski J; Oleszczuk J; Department of Obstetrics and Perinatology, University School of; Medicine, Lublin, Poland. dorotak@mp.pl
- OBJECTIVES: The purpose of our study was to investigate T helper 1/T helper 2 balance in pregnant women with pre-eclampsia. STUDY DESIGN: 18 patients with pre-eclampsia and 20 healthy pregnant women were included in the study. Peripheral blood mononuclear cells (PBMC) were stimulated with phytohaemagglutinin (PHA) for
- Seminal immune response in infertile men with leukocytospermia: effect on antioxidant activity.
- Eur J Obstet Gynecol Reprod Biol. 1999 Oct;86(2):195-202. Unique Identifier : AIDSLINE MED/99437490
- Omu AE; Al-Qattan F; Al-Abdul-Hadi FM; Fatinikun MT; Fernandes S; Reproductive Medicine Unit, Department of Obstetrics and; Gynaecology, Faculty of Medicine, Kuwait University, Safat.
- OBJECTIVE: To investigate the incidence of leukocytospermia and relation to T helper cytokines, tumor necrosis factor alpha (TNFalpha) and interleukin-4 (IL-4), antisperm antibodies and antioxidant activity. Design: Semen samples from 176 infertile men and 24 fertile controls were investigated. METHODOLOGY: The protoc
- Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole.
- FASEB J. 1999 Oct;13(13):1688-98. Unique Identifier : AIDSLINE MED/99438090
- Hess DA; Sisson ME; Suria H; Wijsman J; Puvanesasingham R; Madrenas J; Rieder MJ; Department of Pharmacology and Toxicology, University of Western; Ontario, London, Ontario, Canada.
- Treatment with sulfonamide antibiotics in HIV-infected patients is associated with a high incidence (> 40%) of adverse drug events, including severe hypersensitivity reactions. Sulfonamide reactive metabolites have been implicated in the pathogenesis of these adverse reactions. Sulfamethoxazole hydroxylamine (SMX-HA)
- The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.
- FASEB J. 1999 Oct;13(13):1699-710. Unique Identifier : AIDSLINE MED/99438091
- Vila-Coro AJ; Rodriguez-Frade JM; Martin De Ana A; Moreno-Ortiz MC; Martinez-A C; Mellado M; Department of Immunology and Oncology, Centro Nacional de; Biotecnologia, CSIC-Universidad Autonoma de Madrid, Campus de; Cantoblanco, E-28049 Madrid, Spain.
- The chemokine stromal cell-derived factor (SDF-1alpha), the ligand for the CXCR4 receptor, induces a wide variety of effects that include calcium mobilization, chemotactic responses, bone marrow myelopoiesis, neuronal patterning, and prevention of HIV-1 infection. Nonetheless, little is known of the biochemical pathwa
- The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy.
- FASEB J. 1999 Oct;13(13):1724-32. Unique Identifier : AIDSLINE MED/99438093
- Loo TW; Clarke DM; MRC Group in Membrane Biology, Department of Medicine and; Department of Biochemistry, University of Toronto, Ontario M5S; 1A8, Canada.
- The human multidrug resistance P-glycoprotein (P-gp) contributes to the phenomenon of multidrug resistance during cancer and AIDS chemotherapy. A potential novel strategy to circumvent the effects of P-gp during chemotherapy is to prevent maturation of P-gp during biosynthesis so that the transporter does not reach th
- [Coinfection of hepatitis C virus and human immunodeficiency virus and antiretroviral multitherapies]
- Gastroenterol Clin Biol. 1999 Aug-Sep;23(8-9):878-81. Unique Identifier : AIDSLINE MED/20003332
- Zylberberg H; Pol S; Unite d'Hepatologie, Hopital Necker, Paris.
- Isolation and amino acid sequence of a peptide with vitellogenesis inhibiting activity from the terrestrial isopod Armadillidium vulgare (Crustacea).
- Gen Comp Endocrinol. 1999 Sep;115(3):406-14. Unique Identifier : AIDSLINE MED/99412216
- Greve P; Sorokine O; Berges T; Lacombe C; Van Dorsselaer A; Martin G; Genetique et Biologie des Populations de Crustaces, UMR CNRS; 6556.
- The complete amino acid sequence of a neuropeptide was established using gas-phase microsequencing, mass spectrometry, and reverse transcription-polymerase chain reaction. This peptide, stored in the sinus gland of the terrestrial isopod Armadillidium vulgare, inhibited vitellogenin synthesis by the fat tissue and inh
- Complications after implantation of intraocular devices in patients with cytomegalovirus retinitis.
- Graefes Arch Clin Exp Ophthalmol. 1999 Oct;237(10):824-9. Unique Identifier : AIDSLINE MED/99431983
- Guembel HO; Krieglsteiner S; Rosenkranz C; Hattenbach LO; Koch FH; Ohrloff C; Department of Ophthalmology, University Clinics Frankfurt/Main,; Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.
- PURPOSE: The authors report their surgical experience after sustained-release ganciclovir treatment, as well as replacing empty ganciclovir implants in patients with acquired immune deficiency syndrome (AIDS) and cytomegalovirus (
- Effects of monoclonal antibodies directed at cell surface molecules on murine experimental autoimmune uveoretinitis.
- Graefes Arch Clin Exp Ophthalmol. 1999 Oct;237(10):848-54. Unique Identifier : AIDSLINE MED/99431986
- Ando K; Fujino Y; Mochizuki M; Department of Ophthalmology, Tokyo University School of Medicine,; 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
- BACKGROUND: To elucidate the immunopathogenic mechanism of endogenous uveitis, the effects of monoclonal antibodies to molecules involved in the immune response were studied in murine experimental autoimmune uveoretinitis (EAU). METHODS: Monoclonal antibodies to CD4, CD8, Ia(k), Ia(d), lymphocyte function-associated a
- The efficacy of cervical conization in the treatment of cervical intraepithelial neoplasia in HIV-positive women.
- Gynecol Oncol. 1999 Sep;74(3):428-31. Unique Identifier : AIDSLINE MED/99410366
- Holcomb K; Matthews RP; Chapman JE; Abulafia O; Lee YC; Borges A; Buhl A; Department of Obstetrics and Gynecology, State University of New; York-Health Science Center at Brooklyn, Brooklyn, New York,; 11203, USA.
- OBJECTIVE: The aim of this study was to evaluate the efficacy of cervical conization in the treatment of CIN in HIV-positive women. MATERIALS AND METHODS: Sixty-six HIV-positive women treated with cervical conization for CIN were stratified into four groups based on surgical margin and endocervical curetting (ECC) sta
- Comparison of molecular changes in cervical intraepithelial neoplasia in HIV-positive and HIV-indeterminate subjects.
- Gynecol Oncol. 1999 Sep;74(3):519-26. Unique Identifier : AIDSLINE MED/99410386
- Wistuba II; Syed S; Behrens C; Duong M; Milchgrub S; Muller CY; Jagirdar J; Gazdar AF; Hamon Center for Therapeutic Oncology Research, University of; Texas Southwestern Medical Center, Dallas, Texas, 75235-8593,; USA.
- OBJECTIVE: HIV infection is associated with an increased incidence of cervical malignancy and its precursor lesions (CIN, cervical intraepithelial neoplasia) compared with the general population. We studied the molecular abnormalities in the development of HIV-associated CIN and compared them with those present in CIN
- The significance of ASCUS cytology in HIV-positive women.
- Gynecol Oncol. 1999 Oct;75(1):118-21. Unique Identifier : AIDSLINE MED/99434093
- Holcomb K; Abulafia O; Matthews RP; Chapman JE; Borges A; Lee YC; Buhl A; Division of Gynecologic Oncology, Department of Obstetrics and; Gynecology, Brooklyn, New York, 11203, USA.
- OBJECTIVE: The aim of this study was to determine the incidence and severity of dysplasia associated with a cytologic diagnosis of atypical cells of undetermined significance (ASCUS) in women infected with the human immunodeficiency virus (HIV). METHODS: A cross-sectional analysis of cervical cytology, colposcopic imp
- Attitudes toward prophylactic oophorectomy and screening utilization in women at increased risk of developing hereditary breast/ovarian cancer.
- Gynecol Oncol. 1999 Oct;75(1):122-9. Unique Identifier : AIDSLINE MED/99434094
- Meiser B; Butow P; Barratt A; Friedlander M; Gattas M; Kirk J; Suthers G; Walpole I; Tucker K; Hereditary Cancer Clinic, Prince of Wales Hospital, Sydney, NSW; 2031.
- OBJECTIVES: The aim of this study was to evaluate ovarian cancer screening uptake and attitudes toward prophylactic oophorectomy in women at risk of developing hereditary breast/ovarian cancer. STUDY METHODS: Ninety-five unaffected women, who approached 1 of 14 familial cancer clinics for advice about their breast/ova
- Barriers to social support and support received from their families of origin among gay men with HIV/AIDS.
- Health Soc Work. 1999 Aug;24(3):198-209. Unique Identifier : AIDSLINE MED/99434906
- Kadushin G; School of Social Welfare, University of Wisconsin-Milwaukee; 53201, USA. kadushin@csd.uwm.edu
- The study discussed in this article examined the barriers to obtaining social support and the support received from the family of origin among gay men with HIV/AIDS. The survey was distributed through 21 social service agencies in the Midwest and advertised in two Midwestern newspapers and two national magazines; the
- Long-term incidence of hepatitis B virus resistance to lamivudine in human immunodeficiency virus-infected patients.
- Hepatology. 1999 Nov;30(5):1302-6. Unique Identifier : AIDSLINE MED/20004622
- Benhamou Y; Bochet M; Thibault V; Di Martino V; Caumes E; Bricaire F; Opolon P; Katlama C; Poynard T; Service d'Hepato-Gastroenterologie, Hopital; Pitie-Salpetriere, Paris, France. ybenhamou@teaser.fr
- Hepatitis B virus (HBV) resistance to lamivudine has not been extensively documented in human immunodeficiency virus (HIV)-infected patients. We studied the long-term incidence of HBV resistance to lamivudine in HIV-positive patients. Sixty-six HIV-HBV-coinfected patients were studied while receiving lamivudine (150 m
- Lack of Kaposi's sarcoma-associated virus (KSHV) and detection of human herpes virus 6 and 7 by PCR in African Burkitt's lymphoma from HIV-negative patients [letter; comment]
- Hum Pathol. 1999 Oct;30(10):1269-70. Unique Identifier : AIDSLINE MED/20001747
- Tao Q; Ambinder RF
- CD4 and CD8 T lymphocyte inheritance. Evidence for major autosomal recessive genes.
- Hum Genet. 1999 Oct;105(4):337-42. Unique Identifier : AIDSLINE MED/20008747
- Clementi M; Forabosco P; Amadori A; Zamarchi R; De Silvestro G; Di Gianantonio E; Chieco-Bianchi L; Tenconi R; Genetica Clinica ed Epidemiologica, Dipartimento di Pediatria,; Padova, Italy. clementi@child.pedi.unipd.it
- The CD4/CD8 ratio has long been used for the follow-up and monitor of many infectious diseases. Following the demonstration in 1983 that the CD4/CD8 ratio in the mouse is under genetic control, it was subsequently shown to be controlled by a major locus in man. To define the mode of inheritance of the CD4/CD8 ratio, w
- B7 costimulatory ligand regulates development of the T-cell response to Cryptococcus neoformans.
- Immunology. 1999 Sep;98(1):27-35. Unique Identifier : AIDSLINE MED/99398405
- Monari C; Kozel TR; Casadevall A; Pietrella D; Palazzetti B; Vecchiarelli A; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, Perugia, Italy.
- The contribution of B7 molecules to the induction and maintenance of the T-cell response to the human pathogenic fungus Cryptococcus neoformans was investigated. T-cell activation by C. neoformans was regulated by B7 molecules. This costimulatory signal was necessary for initiation and maintenance of the T-cell respon
- Role of interleukin-4 in down-regulation of contact sensitivity by gammadelta T cells from tolerized T-cell receptor alpha-/- mice.
- Immunology. 1999 Sep;98(1):63-70. Unique Identifier : AIDSLINE MED/99398410
- Szczepanik M; Ptak W; Askenase PW; Department of Immunology, Jagiellonian University College of; Medicine, Krakow, Poland.
- Contact sensitivity (CS) is a classical example of an in vivo T-cell-mediated immune response that is under regulation. Such down-regulation can be mediated by alphabeta T cells in mice that are tolerized by prior exposure to high doses of antigen. In contrast, we demonstrated previously that such high-dose antigen to
- Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice.
- Immunology. 1999 Sep;98(1):71-9. Unique Identifier : AIDSLINE MED/99398411
- Dieli F; Sireci G; Scire E; Salerno A; Bellavia A; Institute of General Pathology, University of Palermo, Italy.
- We have examined the role of endogenously produced interleukin-4 (IL-4) in the contact hypersensitivity (CH) reaction to the haptene trinitrochlorobenzene (TNCB). The CH reaction was abolished in IL-4 genetically deficient mice (IL-4 KO), when compared to wild-type (wt) mice. The CH reaction was restored by treatment
- Interleukin-10-induced CD8 cell proliferation.
- Immunology. 1999 Sep;98(1):80-9. Unique Identifier : AIDSLINE MED/99398412
- Rowbottom AW; Lepper MA; Garland RJ; Cox CV; Corley EG; Department of Pathology and Microbiology, University of; Bristol,UK
- Interleukin (IL)-10, a product of T helper 2 (Th2) lymphocytes, has been shown to be an important regulator of lymphoid and myeloid cells, inhibiting mitogen, peptide and alloantigen-induced T-cell proliferation and IL-2 production. The microenvironment at the time of
- Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages.
- Immunology. 1999 Sep;98(1):98-103. Unique Identifier : AIDSLINE MED/99398414
- Kang BY; Chung SW; Im SY; Choe YK; Kim TS; College of Pharmacy, Chonnam National University, Kwangju,; Republic of Korea.
- Interleukin-12 (IL-12) plays a pivotal role in the development of T-helper 1 (Th1) immune response, which may be involved in the pathogenesis of chronic inflammatory autoimmune disorders. In this study we investigated the effects of sulfasalazine, a drug for treating inflammatory bowel disease and rheumatoid arthritis
- Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro.
- Immunol Cell Biol. 1999 Oct;77(5):385-90. Unique Identifier : AIDSLINE MED/20010099
- Hook S; Camberis M; Prout M; Konig M; Zimmer A; Van Heeke G; Le Gros G; Malaghan Institute of Medical Research, Wellington School of; Medicine, Wellington, New Zealand.mimrsh@wnmeds.ac.nz
- Preproenkephalin (PPNK) mRNA expression has been detected in many cells of the immune system, including monocytes and lymphocytes. In the present paper, the expression of PPNK mRNA in purified CD4+ Th1 and Th2 lymphocyte subpopulations is investigated and correlated with the presence of the opioid neuropeptides leu- a
- Regulation of T helper cell differentiation by respiratory tract dendritic cells.
- Immunol Cell Biol. 1999 Oct;77(5):428-33. Unique Identifier : AIDSLINE MED/20010105
- Stumbles PA; TVW Telethon Institute for Child Health Research (affiliated with; the University of Western Australia), West Perth, Western; Australia, Australia. phils@ichr.uwa.edu.au
- Studies on dendritic cells (DC) of the respiratory and gastric mucosae have identified an extensive network of cells that represent the predominant antigen-presenting cell type at these sites. Under steady-state conditions, respiratory tract DC (RTDC) are specialized for antigen uptake and spontaneously migrate to loc
- Monocyte-derived dendritic cells as a model for the study of HIV-1 infection: productive infection and phenotypic changes during culture in human serum.
- Immunol Cell Biol. 1999 Oct;77(5):442-50. Unique Identifier : AIDSLINE MED/20010107
- Mallon DF; Buck A; Reece JC; Crowe SM; Cameron PU; Immunology Section, Department of Pathology, Fremantle Hospital,; Fremantle, Western Australia.
- Dendritic cells (DC) have been implicated in the initial selection for macrophage-tropic HIV-1 during transmission and in the generation of high-level virus replication during interactions with CD4 T cells. The role of DC as viral reservoirs and the extent of productive infection is unclear, but the ability to generat
- Role of CXCR4 in HIV-1-induced apoptosis of cells with a CD4+, CXCR4+ phenotype [letter]
- Immunol Lett. 1999 Oct 1;70(1):1-3. Unique Identifier : AIDSLINE MED/20007057
- Biard-Piechaczyk M; Robert-Hebmann V; Roland J; Coudronniere N; Devaux C
- The influence of dietary protein antigen on Th1/Th2 balance and cellular immunity.
- Immunol Lett. 1999 Oct 1;70(1):29-35. Unique Identifier : AIDSLINE MED/20007062
- Sato M; Iwakabe K; Kimura S; Nishimura T; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Kanagawa, Japan.
- Dietary administration of ovalbumin (OVA) antigen (Ag) into OVA-specific T cell receptor alphabeta-transgenic (TCR-Tg) mice resulted in the induction of activated CD4+ Th cells expressing CD69 early activation Ag. However, the number of CD4+ Th cells rather decreased by dietary administration of OVA antigen. The produ
- Apoptosis and HIV infection: T-cells fiddle while the immune system burns.
- Immunol Lett. 1999 Oct 1;70(1):5-8. Unique Identifier : AIDSLINE MED/20007058
- Goldberg B; Stricker RB; International DNCB Study Group, San Francisco, CA, USA.
- Enhancement of programmed cell death (apoptosis) of CD4 T-cells by human immunodeficiency virus (HIV) is thought to be an important factor in the pathogenesis of HIV disease. Recent studies have cast doubt on this concept, however, portraying apoptosis as a potent antiviral strategy to eliminate infected cells. These
- Pattern of opportunistic pulmonary infections in HIV sero-positive subjects: observations from Pondicherry, India.
- Indian J Chest Dis Allied Sci. 1999 Jul-Sep;41(3):135-44. Unique Identifier : AIDSLINE MED/20004838
- Arora VK; Kumar SV; Department of Tuberculosis and Chest Diseases, JIPMER Hospital,; Pondicherry.
- Prospective analysis for a period of six-and-a-half years was done in 190 patients with HIV infection, which showed post-primary tuberculosis with sputum positive for acid-fast bacilli in 65% of cases. Extrapulmonary forms of tuberculosis especially lymph nodes infection was more frequent. Cervical group of lymph node
- Control of Leishmania infantum infection is associated with CD8(+) and gamma interferon- and interleukin-5-producing CD4(+) antigen-specific T cells.
- Unique Identifier : AIDSLINE MED/20002526
- Mary C; Auriault V; Faugere B; Dessein AJ
- Visceral leishmaniasis is a severe and lethal disease caused by the protozoan parasites of the genus Leishmania. In areas where leishmaniasis is endemic, most infected individuals control the infection and remain asymptomatic; chemotherapy of visceral leishmaniasis restores some immunity which protects against
- Immune CD8(+) T cells prevent reactivation of Toxoplasma gondii infection in the immunocompromised host.
- Infect Immun. 1999 Nov;67(11):5869-76. Unique Identifier : AIDSLINE MED/20002568
- Khan IA; Green WR; Kasper LH; Green KA; Schwartzman JD; Department of Medicine, Dartmouth Medical School, Lebanon, New; Hampshire 03756, USA. Imtiaz.Khan@dartmouth.edu
- Toxoplasma gondii remains a serious cause of morbidity and mortality in individuals that are immunosuppressed, patients with AIDS in particular. The cellular immune response, especially by gamma interferon (IFN-gamma)-producing CD8(+) T cells, is an essential component of protective immunity against the parasite. In t
- T-cell recognition of Mycobacterium tuberculosis culture filtrate fractions in tuberculosis patients and their household contacts.
- Infect Immun. 1999 Nov;67(11):5967-71. Unique Identifier : AIDSLINE MED/20002581
- Demissie A; Ravn P; Olobo J; Doherty TM; Eguale T; Geletu M; Hailu W; Andersen P; Britton S; Armauer Hansen Research Institute, Addis Ababa, Ministry of; Health, Hossana, Ethiopia.
- We examined the immune responses of patients with active pulmonary tuberculosis (TB) and their healthy household contacts to short-term culture filtrate (ST-CF) of Mycobacterium tuberculosis or molecular mass fractions derived from it. Our goal was to identify fractions strongly recognized by donors and differences am
- Advances in the epidemiology of HIV-associated non-Hodgkin's lymphoma and other lymphoid neoplasms.
- Int J Cancer. 1999 Nov 12;83(4):481-5. Unique Identifier : AIDSLINE MED/99438128
- Franceschi S; Dal Maso L; La Vecchia C; Servizio di Epidemiologia, Centro di Riferimento Oncologico,; Aviano, Italy. epidemiology@ets.it
- The spectrum of HIV-related lymphoid malignancies certainly includes non-Hodgkin s lymphoma (NHL; i.e., chiefly large-cell lymphoma and Burkitt s lymphoma), primary lymphoma of the brain (PBL) and, possibly, Hodgkin s disease (HD). Since the mid-1990s, several epidemiological studi
- Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity.
- Int J Cancer. 1999 Nov 12;83(4):532-40. Unique Identifier : AIDSLINE MED/99438136
- Yang S; Vervaert CE; Burch Jr J; Grichnik J; Seigler HF; Darrow TL; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- Dendritic cells (DCs) are potent inducers of cytotoxic T lymphocytes (CTLs) when pulsed with an antigenic peptide or tumor lysate. In this report, we have used liposome-mediated gene transfer to examine the ability of plasmid DNA encoding the human melanoma-associated antigen gp100 to elicit CD8(+) and CD4(+) T-cell r
- Recombinant gp100 protein presented by dendritic cells elicits a T-helper-cell response in vitro and in vivo.
- Int J Cancer. 1999 Nov 12;83(4):547-54. Unique Identifier : AIDSLINE MED/99438138
- Cochlovius B; Linnebacher M; Zewe-Welschof M; Zoller M; Department of Tumor Progression and Immune Defense, German Cancer; Research Center, Heidelberg, Germany.
- Induction of a helper T (TH)-cell response is a critical element in the generation of anti-tumor immunity. The majority of immunotherapeutic approaches have so far been concerned with the generation of cytotoxic T lymphocytes (CTLs). This also accounts for gp100, a melanoma-associated protein which induces a potent CT
- Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines.
- Int J Immunopharmacol. 1999 Sep;21(9):609-15. Unique Identifier : AIDSLINE MED/99429738
- Raychaudhuri SP; Farber EM; Raychaudhuri SK; Psoriasis Research Institute, Palo Alto, CA 94301, USA.
- Peptide T is an octapeptide from the V2 region of HIV-1 gp120. It has been shown to resolve psoriatic lesions--an inflammatory skin disease. The mechanisms of anti-inflammatory actions of peptide T are not well understood. Th1 cytokines such as IL-2 , and IFN-gamma are
- Immunology of the cutaneous disorders of pregnancy.
- Int J Dermatol. 1999 Oct;38(10):721-9. Unique Identifier : AIDSLINE MED/20023697
- Garcia-Gonzalez E; Ahued-Ahued R; Arroyo E; Montes-De-Oca D; Granados J; Instituto Nacional de Perinatologia, SS Ciudad de Mexico,; Mexico.
- Pemphigus vegetans in association with human immunodeficiency virus.
- Int J Dermatol. 1999 Oct;38(10):778-81. Unique Identifier : AIDSLINE MED/20023709
- Lateef A; Packles MR; White SM; Don PC; Weinberg JM; Department of Dermatology, New York Medical College-Metropolitan; Hospital Center, New York 10029, USA.
- Molluscum contagiosum: its clinical, histopathologic, and immunohistochemical spectrum.
- Int J Dermatol. 1999 Sep;38(9):664-72. Unique Identifier : AIDSLINE MED/99445270
- Smith KJ; Yeager J; Skelton H; Department of Dermatology, National Naval Medical Center,; Bethesda, Maryland 20089, USA.
- Surgical treatment of HIV-related immune thrombocytopenia.
- Int Surg. 1999 Jan-Mar;84(1):81-5. Unique Identifier : AIDSLINE MED/99347374
- Aboolian A; Ricci M; Shapiro K; Connors A; LaRaja RD; Department of Surgery, Cabrini Medical Center, The Mount Sinai; School of Medicine, New York, New York 10003, USA.; gorshap@aol.com
- Immune related thrombocytopenia has been described extensively in patients infected with the human immunodeficiency virus (HIV). The efficacy and safety of splenectomy performed in 21 patients affected with HIV-related immune thrombocytopenia (platelet count less than 50,000/mm3), between 1992 and 1996, were evaluated
- The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.
- Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2898-905. Unique Identifier : AIDSLINE MED/20015843
- Silver PB; Chan CC; Wiggert B; Caspi RR; Laboratory of Immunology, National Eye Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.
- PURPOSE: Experimental autoimmune uveoretinitis (EAU) in mice is an important model for elucidating basic mechanisms in autoimmune eye disease. The need for pertussis toxin (PTX) as an additional adjuvant to elicit EAU has limited the usefulness of this model in some types of studies by introducing a pleiotropic factor
- Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry.
- Invest Ophthalmol Vis Sci. 1999 Nov;40(12):3036-40. Unique Identifier : AIDSLINE MED/20015863
- Leonardi A; DeFranchis G; Zancanaro F; Crivellari G; De Paoli M; Plebani M; Secchi AG; Department of Physiopathologic Optics, Institute of; Ophthalmology, University of Padua, Italy. mdvol@tin.it
- PURPOSE: Th2 lymphocytes may play a key role in the development of allergic diseases such as vernal keratoconjunctivitis (VKC). Cytokine flow cytometry of tear samples was used to identify the phenotypical and functional properties of lymphocytes at the actual site of the allergic reaction. METHODS: Tear and blood sam
- New antiviral agents for the therapy of chronic hepatitis B virus infection.
- Intervirology. 1999 Sep;42(2-3):125-44. Unique Identifier : AIDSLINE MED/99447702
- Zoulim F; Trepo C; INSERM Unit 271, and Liver Unit, Hotel-Dieu Hospital, Lyon,; France.
- The development of new antiviral strategies for the treatment of chronic hepatitis B remains a major goal since hepatitis virus (HBV) is resistant to interferon treatment as well as to new nucleoside analogs. HBV is a small DNA virus that replicates its genome via a reverse transcription step. The viral polymerase has
- Stevens-Johnson syndrome after exposure to a pesticide in a patient with AIDS [letter]
- Ir Med J. 1999 Aug;92(5):374. Unique Identifier : AIDSLINE MED/99451556
- Roca B; Tomas G; Climent A
- Renegotiating HIV/AIDS prevention for adolescents.
- Issues Compr Pediatr Nurs. 1998 Oct-Dec;21(4):203-16. Unique Identifier : AIDSLINE MED/20000896
- Carasso MJ; Saint Vincents Medical Center, New York, New York 10011, USA.; mjcarasso@aol.com
- According to the Centers for Disease Control in 1997, approximately 25% of the estimated new human immunodeficiency virus (HIV) infections in the United States may occur in youths under 20 years. Based on the research regarding adolescents and HIV disease, it is clear that several issu
- Altered apoptotic profiles in irradiated patients with increased toxicity [see comments]
- Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):707-14. Unique Identifier : AIDSLINE MED/99452057
- Crompton NE; Miralbell R; Rutz HP; Ersoy F; Sanal O; Wellmann D; Bieri S; Coucke PA; Emery GC; Shi YQ; Blattmann H; Ozsahin M; Radiation Medicine, Life Sciences Department, Paul Scherrer; Institute, Villigen-PSI, Switzerland. crompton@psi.ch
- PURPOSE: A retrospective study of radiation-induced apoptosis in CD4 and CD8 T-lymphocytes, from 12 cancer patients who displayed enhanced toxicity to radiation therapy and 9 ataxia telangiectasia patients, was performed to test for altered response compared to healthy blood-donors and normal cancer patients. METHODS
- Efficacy and safety of an intravenous induction therapy for treatment of disseminated Mycobacterium avium complex infection in AIDS patients: a pilot study.
- J Antimicrob Chemother. 1999 Jul;44(1):129-31. Unique Identifier : AIDSLINE MED/99387578
- Roger PM; Carles M; Agussol-Foin I; Pandiani L; Keita-Perse O; Mondain V; De Salvador F; Dellamonica P; Service des Maladies Infectieuses et Tropicales, Hopital de; l'Archet I, Nice, France.
- Monotherapy with macrolides for the treatment of disseminated Mycobacterium avium complex (MAC) bacteraemia leads to drug resistance and relapse of bacteraemia. Gastrointestinal intolerance is a common reason for treatment withdrawal of multidrug regimens. We have assessed the efficacy and safety of initial parenteral
- Acute pancreatitis with severe lactic acidosis in an HIV-infected patient on didanosine therapy [letter]
- J Antimicrob Chemother. 1999 Jul;44(1):137-8. Unique Identifier : AIDSLINE MED/99387582
- Allaouchiche B; Duflo F; Cotte L; Mathon L; Chassard D
- Lentivirus-derived antimicrobial peptides: increased potency by sequence engineering and dimerization.
- J Antimicrob Chemother. 1999 Jul;44(1):33-41. Unique Identifier : AIDSLINE MED/99387564
- Tencza SB; Creighton DJ; Yuan T; Vogel HJ; Montelaro RC; Mietzner TA; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, PA 15261, USA.
- We have previously described a family of cationic amphipathic peptides derived from lentivirus envelope proteins that have properties similar to those of naturally occurring antimicrobial peptides. Here, we explored the effects of amino acid truncations and substitutions on the antimicrobial potency and selectivity of
- In-vitro interactions of itraconazole with flucytosine against clinical isolates of Cryptococcus neoformans.
- J Antimicrob Chemother. 1999 Jul;44(1):65-70. Unique Identifier : AIDSLINE MED/99387567
- Barchiesi F; Gallo D; Caselli F; Di Francesco LF; Arzeni D; Giacometti A; Scalise G; Istituto di Malattie Infettive e Medicina Pubblica Universita; degli Studi di Ancona, Ospedale Umberto I, Italy.; cmalinf@popcis.unian.it
- Treatment failures can occur in AIDS patients infected with Cryptococcus neoformans, despite aggressive antifungal therapy. Combination regimens with additive or synergic drugs could provide additional options for treating cryptococcosis. We studied the effects of itraconazole combined with flucytosine against 16 stra
- Flow cytometric assessment of amphotericin B susceptibility in Leishmania infantum isolates from patients with visceral leishmaniasis.
- J Antimicrob Chemother. 1999 Jul;44(1):71-6. Unique Identifier : AIDSLINE MED/99387568
- Di Giorgio C; Faraut-Gambarelli F; Imbert A; Minodier P; Gasquet M; Dumon H; Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de; Pharmacie, Marseille, France.
- Amphotericin B susceptibility was measured by a flow cytometric membrane potential assay in Leishmania infantum promastigotes isolated from 11 immunocompetent children treated with liposomal amphotericin B and 19 HIV-infected young adults treated with intralipid amphotericin B. Susceptibility levels were measured by t
- Infections in recipients of blood and marrow transplantation.
- Hematol Oncol Clin North Am. 1999 Oct;13(5):1065-89, viii. Unique Identifier : AIDSLINE MED/20020832
- van Burik JA; Weisdorf DJ; Department of Medicine, University of Minnesota, Minneapolis,; USA.
- The approach to infections in blood and marrow transplant (BMT) recipients involves an understanding of clinical infection syndromes and the natural history of individual infections, taken in the context of patterns of immunosuppression after transplantation and mechanisms underlying immune system reconstitution over
- Medical illness in patients with schizophrenia.
- J Clin Psychiatry. 1999;60 Suppl 21:10-5. Unique Identifier : AIDSLINE MED/20014172
- Goldman LS; Department of Psychiatry, University of Chicago, Ill 60637-1470,; USA. larry@yoda.bsd.uchicago.edu
- Research into the relationship between physical illness and schizophrenia has revealed that patients with schizophrenia may be at decreased risk for certain disorders, such as rheumatoid arthritis and allergies, but at increased risk for others, including substance abuse and polydipsia. Although such knowledge may ult
- The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation.
- J Biol Chem. 1999 Sep 24;274(39):27339-42. Unique Identifier : AIDSLINE MED/99419004
- Karin M; Laboratory of Gene Regulation and Signal Transduction, Department; of Pharmacology, University of California, San Diego, La Jolla,; California 92093-0636, USA. karinoffice@ucsd.edu
- Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants.
- J Biol Chem. 1999 Sep 24;274(39):27505-12. Unique Identifier : AIDSLINE MED/99419027
- Appay V; Brown A; Cribbes S; Randle E; Czaplewski LG; British Biotech Pharmaceuticals Ltd., Watlington Road, Oxford OX4; 5LY, United Kingdom.
- The biology of RANTES (regulated on activation normal T cell expressed) aggregation has been investigated using RANTES and disaggregated variants, enabling comparison of aggregated, tetrameric, and dimeric RANTES forms. Disaggregated variants retain their G(i)-type G protein-coupled receptor-mediated biological activi
- Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells.
- J Biol Chem. 1999 Sep 24;274(39):27617-22. Unique Identifier : AIDSLINE MED/99419043
- Marchio S; Primo L; Pagano M; Palestro G; Albini A; Veikkola T; Cascone I; Alitalo K; Bussolino F; Institute for Cancer Research and Treatment, Department of; Genetics, University of Torino Medical School, 10060 Candiolo,; Italy.
- Recent evidence suggesting vascular endothelial growth factor-C (VEGF-C), which is a regulator of lymphatic and vascular endothelial development, raised the question whether this molecule could be involved in Kaposi s sarcoma (KS), a strongly angiogenic and inflammatory tumor often associated with infection by human i
- New human immunodeficiency virus, type 1 reverse transcriptase (HIV-1 RT) mutants with increased fidelity of DNA synthesis. Accuracy, template binding, and processivity.
- J Biol Chem. 1999 Sep 24;274(39):27666-73. Unique Identifier : AIDSLINE MED/99419049
- Kim B; Ayran JC; Sagar SG; Adman ET; Fuller SM; Tran NH; Horrigan J; Department of Microbiology and Immunology, University of; Rochester, Rochester, New York 14642, USA.; baek_kim@urmc.rochester.edu
- Infidelity of DNA synthesis by human immunodeficiency virus, type 1 reverse transcriptase (HIV-1 RT) is a presumptive determinant of HIV-1 hypervariability and is incompletely understood at the mechanistic and structural levels. Amino acid substitution at only three residues, including Asp-76 (Kim, B., Hathaway, T. R.
- The anti-HIV pseudopeptide HB-19 forms a complex with the cell-surface-expressed nucleolin independent of heparan sulfate proteoglycans.
- J Biol Chem. 1999 Sep 24;274(39):27875-84. Unique Identifier : AIDSLINE MED/99419076
- Nisole S; Krust B; Callebaut C; Guichard G; Muller S; Briand JP; Hovanessian AG; Unite de Virologie et Immunologie Cellulaire, URA 1930 CNRS,; Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15,; France.
- The HB-19 pseudopeptide 5[Kpsi(CH(2)N)PR]-TASP, psi(CH(2)N) for reduced peptide bond, is a specific inhibitor of human immunodeficiency virus (HIV) infection in different CD4(+) cell lines and in primary T-lymphocytes and macrophages. Here, by using an experimental CD4(+) cell model to monitor HIV entry and infection,
- ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB.
- J Biol Chem. 1999 Sep 24;274(39):27981-8. Unique Identifier : AIDSLINE MED/99419090
- Yang X; Chen Y; Gabuzda D; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.
- Human immunodeficiency virus type 1 (HIV-1) can establish latent infection following provirus integration into the host genome. NF-kappaB plays a critical role in activation of HIV-1 gene expression by cytokines and other stimuli, but the signal transduction pathways that regulate the switch from latent to productive
- In vitro assembly of human immunodeficiency virus type 1 Gag protein.
- J Biol Chem. 1999 Sep 24;274(39):27997-8002. Unique Identifier : AIDSLINE MED/99419092
- Morikawa Y; Goto T; Sano K; The Kitasato Institute, Shirokane 5-9-1, Minato-ku, Tokyo; 108-8642, Japan. ymorikawa@kitasato.or.jp
- Retroviral Gag protein is sufficient to produce Gag virus-like particles when expressed in higher eukaryotic cells. Here we describe the in vitro assembly reaction of human immunodeficiency virus Gag protein, which consists of two sequential steps showing the optimal conditions for each reaction. Following expression
- Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity.
- J Biol Chem. 1999 Oct 1;274(40):28175-84. Unique Identifier : AIDSLINE MED/99428480
- Wisniewski M; Palaniappan C; Fu Z; Le Grice SF; Fay P; Bambara RA; Department of Biochemistry, University of Rochester, Rochester,; New York 14642, USA.
- Mutations in the primer grip region of human immunodeficiency virus reverse transcriptase (HIV-RT) affect its replication fidelity. The primer grip region (residues 227-235) correctly positions the 3 -ends of primers. Point mutations were created by alanine substitution at positions 224-235. Error frequencies were mea
- Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides.
- J Biol Chem. 1999 Oct 1;274(40):28198-205. Unique Identifier : AIDSLINE MED/99428483
- Rusnati M; Tulipano G; Spillmann D; Tanghetti E; Oreste P; Zoppetti G; Giacca M; Presta M; Unit of General Pathology, Department of Biomedical Sciences,; School of Medicine, University of Brescia, 25123 Brescia, Italy.
- Tat protein, a transactivating factor of the human immunodeficiency virus type I, acts also as an extracellular molecule. Heparin affects the bioavailability and biological activity of extracellular Tat (Rusnati, M., Coltrini, D., Oreste, P., Zoppetti, G., Albini, A., Noonan, D., D Adda di Fagagna, F., Giacca, M., and
- CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains.
- J Biol Chem. 1999 Oct 1;274(40):28413-9. Unique Identifier : AIDSLINE MED/99428512
- Wang Z; Lee B; Murray JL; Bonneau F; Sun Y; Schweickart V; Zhang T; Peiper SC; Henry Vogt Cancer Research Institute, University of Louisville,; Louisville, Kentucky 40202, USA.
- Human (H-) CCR5 is the primary coreceptor for ENV-mediated fusion by R5 strains of human immunodeficiency virus type 1, whereas mouse (M-) CCR5 lacks this function. An array of 23 H/M-CCR5 hybrids containing increasing amounts of H-CCR5 extending from the N terminus generated by random chimeragenesis had a biphasic pa
- Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor.
- J Biol Chem. 1999 Oct 1;274(40):28745-50. Unique Identifier : AIDSLINE MED/99428556
- Mirzabekov T; Bannert N; Farzan M; Hofmann W; Kolchinsky P; Wu L; Wyatt R; Sodroski J; Department of Cancer Immunology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.
- Seven-transmembrane segment, G protein-coupled receptors (GPCRs) play important roles in many biological processes in which pharmaceutical intervention may be useful. High level expression and native purification of GPCRs are important steps in the biochemical and structural characterization of these molecules. Here,
- Multifaceted activities of the HIV-1 transactivator of transcription, Tat.
- J Biol Chem. 1999 Oct 8;274(41):28837-40. Unique Identifier : AIDSLINE MED/99436072
- Jeang KT; Xiao H; Rich EA; Laboratory of Molecular Microbiology, NIAID, National Institutes; of Health, Bethesda, Maryland 20892, USA. kj7e@nih.gov
- BiP-binding sequences in HIV gp160. Implications for the binding specificity of bip.
- J Biol Chem. 1999 Oct 15;274(42):29850-7. Unique Identifier : AIDSLINE MED/99445539
- Knarr G; Modrow S; Todd A; Gething MJ; Buchner J; Institut fur Biophysik & Physikalische Biochemie, Universitat; Regensburg, 93040 Regensburg, Germany.
- BiP, a resident endoplasmic reticulum member of the HSP70 family of molecular chaperones, associates transiently with a wide variety of newly synthesized exocytotic proteins. In addition to immunoglobulin heavy and light chains, the first natural substrates identified for BiP, a number of viral polypeptides including
- Characterization of the sequence of interactions of the fusion domain of the simian immunodeficiency virus with membranes. Role of the membrane dipole potential.
- J Biol Chem. 1999 Oct 15;274(42):29951-9. Unique Identifier : AIDSLINE MED/99445552
- Cladera J; Martin I; Ruysschaert JM; O'Shea P; Laboratoire de Chimie-Physique des Macromolecules aux Interfaces; Universite Libre de Bruxelles, 1050 Brussels, Belgium.
- The simian immunodeficiency virus fusion peptide constitutes a 12-residue N-terminal segment of the gp32 protein that is involved in the fusion between the viral and cellular membranes, facilitating the penetration of the virus in the host cell. Simian immunodeficiency virus fusion peptide is a hydrophobic peptide tha
- Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization.
- J Biol Chem. 1999 Oct 22;274(43):31076-86. Unique Identifier : AIDSLINE MED/99453013
- Orsini MJ; Parent JL; Mundell SJ; Benovic JL; Department of Microbiology, Kimmel Cancer Institute, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.
- The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for entry of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization as well as internalization in response to stimulation with phorbol esters and ligand (SDF-1alpha). We investigated the trafficking of this recep
- Significance of the human immunodeficiency virus infection in patients submitted to cardiac surgery.
- J Cardiovasc Surg (Torino). 1999 Aug;40(4):477-9. Unique Identifier : AIDSLINE MED/20000002
- Everson; Zeigler R; Sabbaga Amato M; Varejao Strabelli TM; Aranha Camargo LF; Grinberg M; Domingos Jatene A; Department of Epidemiology and Quality Control, Instituto do; Coracao do Hospital das Clinicas da Faculdade de Medicina da; Universidade de Sao Paulo, Brazil.
- BACKGROUND: To realize if cardiac surgery could interfere with the evolution of HIV infected patients to the acquired immunodeficiency syndrome (AIDS). METHODS: The study group consisted of 30 HIV positive patients (0.21%) among 14,785 who underwent cardiac surgery at the Heart Institute of University of Sao Paulo Med
- Antisense oligonucleotides as therapeutic agents.
- J Cell Physiol. 1999 Nov;181(2):251-7. Unique Identifier : AIDSLINE MED/99428592
- Galderisi U; Cascino A; Giordano A; Department of Pathology, Jefferson Medical College of Thomas; Jefferson University, Philadelphia, Pennsylvania, USA.
- Antisense oligonucleotides can block the expression of specific target genes involved in the development of human diseases. Therapeutic applications of antisense techniques are currently under investigation in many different fields. The use of antisense molecules to modify gene expression is variable in its efficacy a
- A comparative review of conventional and lipid formulations of amphotericin B.
- J Clin Pharm Ther. 1999 Aug;24(4):249-57. Unique Identifier : AIDSLINE MED/99405834
- Robinson RF; Nahata MC; Department of Pharmacy, Children's Hospital and College of; Pharmacy, Ohio State University, Columbus, USA.
- Over the past 15 years, factors suh as corticosteroid treatment, cytotoxic chemotherapy, excessive use of broad spectrum antibiotics and HIV have led to an increased risk of serious fungal infections in both adults and pediatric patients. This increase in invasive fungal infections poses increasing difficulty in their
- A quantitative duplex PCR technique for measuring amounts of cell-associated Marek's disease virus: differences in two populations of lymphoma cells.
- J Virol Methods. 1999 Sep;82(1):27-37. Unique Identifier : AIDSLINE MED/99435244
- Burgess SC; Davison TF; Institute for Animal Health, Compton, Newbury, Berkshire, UK.
- A duplex polymerase chain reaction (PCR) was developed to measure Marek s disease virus (MDV) load in two subpopulations of Marek s disease (MD) lymphoma cells from chickens. PCR primers were designed using the sequence of the MDV-ICP4 gene and the chicken IFNgamma gene. Each set of primers was present in the same rea
- Improved performance of seroconversion with a 4th generation HIV antigen/antibody assay.
- Unique Identifier : AIDSLINE MED/99435249
- van Binsbergen J; Siebelink A; Jacobs A; Keur W; Bruynis F; van de Graaf M; van der Heijden J; Kambel D; Toonen J; Organon Teknika, Boxtel, The Netherlands.
- Recently a new fourth generation microELISA for large scale blood screening has been described in which HIV p24 Ag detection was integrated in an anti-HIV-1/-2 and anti-HIV-1 group O assay based on a direct assay format: (Vironostika HIV Uni-Form II Ag/Ab (Van Binsbergen et al., (1998)). When compared to the third gen
- Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes.
- J Clin Endocrinol Metab. 1999 Oct;84(10):3739-44. Unique Identifier : AIDSLINE MED/99450858
- Willheim M; Thien R; Schrattbauer K; Bajna E; Holub M; Gruber R; Baier K; Pietschmann P; Reinisch W; Scheiner O; Peterlik M; Institute of General and Experimental Pathology, Clinic of; Internal Medicine IV, University of Vienna, Austria.; martin.willheim@akh-wien.ac.at
- We studied the possible regulatory effects of 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3] on cytokine production and differentiation of subsets of CD4+ [T helper 1 (Th1) and Th2] and CD8+ [T cytotoxic 1 (Tc1) and Tc2] lymphocytes at the single cell level. PBMC from healthy donors were cultured with or without 1a
- Role of chemokines in the regulation of Th1/Th2 and autoimmune encephalomyelitis.
- J Clin Immunol. 1999 Sep;19(5):273-9. Unique Identifier : AIDSLINE MED/20004261
- Kennedy KJ; Karpus WJ; Department of Pathology, Immunobiology Center, Robert H. Lurie; Cancer Center, and Institute for Neuroscience, Northwestern; University Medical School, Chicago, Illinois 60611, USA.
- Chemokines are low molecular weight chemotactic peptides that bind seven transmembrane-spanning, G protein-coupled receptors and deliver signals leading to T cell costimulation, hematopoeisis, cytokine expression, T cell differentiation, and integrin activation. Experimental autoimmune encephalomyelitis (EAE) is a CD4
- Chemokines as molecular targets for therapeutic intervention.
- J Clin Immunol. 1999 Sep;19(5):280-92. Unique Identifier : AIDSLINE MED/20004262
- Howard OM; Oppenheim JJ; Wang JM; Laboratory of Molecular Immunoregulation, Division of Basic; Sciences, Frederick Cancer Research and Development Center, NCI; and IRSP, SAIC Frederick, Maryland, USA.
- Despite the youth of the chemokine field, many antagonists of chemokine function have already been identified and tested at the preclinical level. These include neutralizing antibodies, peptidyl and non-peptidyl antagonists and non-specific immunosuppressive agents. These early studies suggest that chemokine agonists
- HIV infection and pathogenesis: what about chemokines?
- J Clin Immunol. 1999 Sep;19(5):293-9. Unique Identifier : AIDSLINE MED/20004263
- Gallo RC; Garzino-Demo A; DeVico AL; University of Maryland Biotechnology Institute, University of; Maryland, Baltimore 21201-1192, USA. coleman@umbi.umd.edu
- Several chemotactic cytokines, or chemokines. inhibit HIV replication by blocking or down regulating chemokine receptors that serve as entry cofactors for the virus. Although the role of chemokine receptors in HIV pathogenesis has been the subject of intense interest, chemokines are comparatively less seriously consid
- Kinetics of lymphokine production in HIV+ patients treated with highly active antiretroviral therapy and interleukin 2.
- J Clin Immunol. 1999 Sep;19(5):317-25. Unique Identifier : AIDSLINE MED/20004267
- De Paoli P; Zanussi S; Caggiari L; Bortolin MT; D'Andrea M; Simonelli C; Tirelli U; Department of Microbiology, Immunology and Virology, Centro di; Riferimento Oncologico, IRCCS, Aviano, Italy.
- This study presents the kinetics of CD4/CD25 cell numbers, serum sCD25 levels, and intracellular production and release of interleukin-2 ( IL-2 ) and interleukin-16 (IL-16) in 11 HIV+ patients treated with six cycles of highly active antiretroviral therapy (HAART) plus s
- Airway remodeling in asthma.
- J Clin Invest. 1999 Oct;104(8):1001-6. Unique Identifier : AIDSLINE MED/99454802
- Elias JA; Zhu Z; Chupp G; Homer RJ; Section of Pulmonary and Critical Care Medicine, Department of; Internal Medicine, Yale University School of Medicine, New Haven,; Connecticut 06520, USA.
- Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation.
- J Clin Invest. 1999 Oct;104(8):1021-9. Unique Identifier : AIDSLINE MED/99454808
- Randolph DA; Stephens R; Carruthers CJ; Chaplin DD; Division of Allergy and Immunology, Department of Internal; Medicine and Center for Immunology, and Howard Hughes Medical; Institute, Washington University School of Medicine, St. Louis,; Missouri 63110, USA.
- We have studied the actions of helper T lymphocyte-1 and -2 (Th1 and Th2) cells in an acute model of eosinophilic airway inflammation by infusing chicken ovalbumin-specific (OVA-specific) Th1 cells, Th2 cells, or both into unsensitized mice and challenging the mice with an OVA aerosol. OVA challenge after infusion of
- Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells.
- J Clin Invest. 1999 Oct;104(8):1061-9. Unique Identifier : AIDSLINE MED/99454812
- Jordan NJ; Kolios G; Abbot SE; Sinai MA; Thompson DA; Petraki K; Westwick J; School of Pharmacy and Pharmacology, University of Bath, Bath BA2; 7AY, United Kingdom. N.J.Jordan@bath.ac.uk
- In addition to their role as regulators of leukocyte migration and activation, chemokines and their receptors also function in angiogenesis, growth regulation, and HIV-1 pathogenesis--effects that involve the action of chemokines on nonhematopoietic cells. To determine whether chemokine receptors are expressed in huma
- Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions.
- J Clin Invest. 1999 Oct;104(8):1097-105. Unique Identifier : AIDSLINE MED/99454816
- Vestergaard C; Yoneyama H; Murai M; Nakamura K; Tamaki K; Terashima Y; Imai T; Yoshie O; Irimura T; Mizutani H; Matsushima K; Department of Molecular Preventive Medicine, University of Tokyo,; Tokyo 113-0033, Japan.
- We have examined the expression of chemokines and their receptors in the atopic dermatitis-like (AD-like) lesions of NC/Nga mice. Such lesions develop when the mice are kept in conventional conditions, but not when they are kept isolated from specific pathogens. The thymus- and activation-regulated chemokine TARC is u
- Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation.
- J Clin Invest. 1999 Oct;104(8):985-93. Unique Identifier : AIDSLINE MED/99454800
- Ray A; Cohn L; Section of Pulmonary and Critical Care Medicine, Yale University; School of Medicine, New Haven, Connecticut 06520, USA.; Anuradha.Ray@yale.edu
- Trimethoprim/sulfamethoxazole does not affect the steady-state disposition of indinavir.
- J Clin Pharmacol. 1999 Oct;39(10):1077-84. Unique Identifier : AIDSLINE MED/99446140
- Sturgill MG; Seibold JR; Boruchoff SE; Yeh KC; Haddix H; Deutsch P; College of Pharmacy, Rutgers, State University of New Jersey,; Piscataway 08854-8020, USA.
- This study evaluates the safety and potential pharmacokinetic interaction between indinavir and trimethoprim/sulfamethoxazole (TMP/SMZ). In a randomized, three-period crossover fashion, 12 healthy adults received 1 week of indinavir sulfate 400 mg ora
- Altered pharmacokinetics of indinavir by a novel nonnucleoside reverse transcriptase inhibitor (HBY-097): a pharmacokinetic evaluation in HIV-positive patients.
- J Clin Pharmacol. 1999 Oct;39(10):1085-93. Unique Identifier : AIDSLINE MED/99446141
- Hayashi S; Jayesekera D; Jayewardene A; Shah A; Thevanayagam L; Aweeka F; Department of Clinical Pharmacy, University of California, San; Francisco 94143-0622, USA.
- HBY-097 (HBY), an investigational nonnucleoside reverse transcriptase inhibitor (NNRTI), and indinavir (IDV) share a common metabolic pathway, cytochrome P4503A4 (CYP3A4), and may clinically be used together as well as with zidovudine (ZDV). Thus, the
- Ecthyma gangrenosum in an AIDS patient with normal neutrophil count.
- J Am Acad Dermatol. 1999 Nov;41(5 Pt 2):840-1. Unique Identifier : AIDSLINE MED/20005983
- Kim EJ; Foad M; Travers R; Department of Dermatology, Boston University School of Medicine,; Massachusetts 02118, USA.
- Ecthyma gangrenosum is the cutaneous manifestation of Pseudomonas aeruginosa septicemia, typically affecting immunosuppressed patients, particularly those with neutropenia. Association with HIV disease has been rarely reported. We describe an unusual presentation of solitary ecthyma gangrenosum on the face of a non-ne
- Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection.
- J Am Acad Dermatol. 1999 Nov;41(5 Pt 2):847-50. Unique Identifier : AIDSLINE MED/20005986
- Colebunders R; Depraetere K; Verstraeten T; Lambert J; Hauben E; Van Marck E; Maurer T; Banuls AL; Dujardin JC; Department of Clinical Sciences, Institute of Tropical Medicine,; Antwerp, Belgium. bcoleb@itg.be
- Two HIV infected patients with visceral leishmaniasis and unusual cutaneous lesions are described. The first patient developed linear brown macules containing Leishmania parasites on the fingers and palms of the hands. This patient never received highly active antiretroviral treatment and the visceral leishmaniasis co
- Durable loss of a malignant T-cell clone in a stage IV cutaneous T-cell lymphoma patient treated with high-dose interferon and photopheresis.
- J Am Acad Dermatol. 1999 Nov;41(5 Pt 2):880-3. Unique Identifier : AIDSLINE MED/20005996
- Haley HR; Davis DA; Sams WM; Department of Dermatology, University of Alabama at Birmingham,; 35233, USA.
- Stage IV cutaneous T-cell lymphoma (CTCL) has a notoriously poor prognosis and many treatment options exist. We describe the successful treatment of a case of stage IV CTCL with combination photopheresis and high-dose interferon alfa (IFNalpha). The patient was treated with
- Differentiation of malignant lymphoma and non-lymphoma by an occlusive dressing method employing bromodeoxyuridine.
- J Dermatol. 1999 Sep;26(9):549-57. Unique Identifier : AIDSLINE MED/20005147
- Ohtake N; Kanzaki T; Nakano R; Department of Dermatology, Kagoshima Prefectural Oshima Hospital,; Naze, Japan.
- Although lymphoma cells can proliferate in skin tissue, lymphocytes which have infiltrated the skin due to inflammatory changes are generally unable to do so. It may be possible to differentiate malignant lymphomas from benign lymphocytic infiltrations in skin tissue by detection of cell cycle-related antigens. We dev
- Malassezia spp carriage in patients with seborrheic dermatitis.
- J Dermatol. 1999 Sep;26(9):558-61. Unique Identifier : AIDSLINE MED/20005148
- Pechere M; Krischer J; Remondat C; Bertrand C; Trellu L; Saurat JH; Department of Dermatology, Geneva University Hospital,; Switzerland.
- The role of Malassezia spp in seborrheic dermatitis (SD) is controversial. To compare the cutaneous density and the cultural characteristics of Malassezia in persons with or without SD, quantitative cultures were obtained by stripping the forehead with a tape placed on Leeming and Notman medium. Plates were incubated
- Patient-ventilator asynchrony during noninvasive ventilation: the role of expiratory trigger [see comments]
- Intensive Care Med. 1999 Jul;25(7):662-7. Unique Identifier : AIDSLINE MED/99399589
- Calderini E; Confalonieri M; Puccio PG; Francavilla N; Stella L; Gregoretti C; Terapia Intensiva Malattie Infettive CSL, IRCCS H San Raffaele,; Milano, Italy.
- OBJECTIVE: Air leaks around the mask are very likely to occur during noninvasive ventilation, in particular when prolonged ventilatory treatment is required. It has been suggested that leaks from the mask may impair the expiratory trigger cycling mechanism when inspiratory pressure support ventilation (PSV) is used. T
- Quality of life in women with symptomatic HIV/AIDS.
- J Adv Nurs. 1999 Sep;30(3):597-605. Unique Identifier : AIDSLINE MED/99429021
- Sarna L; van Servellen G; Padilla G; Brecht ML; University of California, Los Angeles School of Nursing; 90095-6918, USA. Lsarna@sonnet.ucla.edu
- Despite the increasing incidence of cases of human immune deficiency virus (HIV) infection and of acquired immune deficiency syndrome (AIDS) in women, there is a serious lack of information about those women s quality of life (QoL). The purpose of this exploratory descriptive study was to describe QoL using an HIV-spe
- Experiences of violence in HIV-seropositive women in the south-eastern United States of America.
- J Adv Nurs. 1999 Sep;30(3):606-15. Unique Identifier : AIDSLINE MED/99429022
- Sowell R; Seals B; Moneyham L; Guillory J; Mizuno Y; College of Nursing, University of South Carolina, Columbia 20208,; USA. richard.sowell@sc.edu
- Women represent one of the fastest growing groups being diagnosed with HIV infection. Because of the circumstances under which they live, women at the highest risk for HIV infection may also be at risk for verbal, physical and sexual violence. The purpose of this study was to examine the frequency and type of violence
- Adolescents and HIV: theory-based approaches to education of nurses.
- J Adv Nurs. 1999 Sep;30(3):687-96. Unique Identifier : AIDSLINE MED/99429031
- Stewart KE; DiClemente RJ; Ross D; Department of Psychology, University of Alabama at Birmingham; 35294-2050, USA.
- HIV infection is increasingly prevalent in adolescents, and primary prevention programmes have been most effective when based on existing theories, including social cognitive theory (SCT). Nurses play an important role in assessing adolescents risk for HIV infection and in recommending preventive behaviour change, if
- The attitudes and attributions of student nurses: do they alter according to a person's diagnosis or sexuality and what is the effect of nurse training?
- Unique Identifier : AIDSLINE MED/99429037
- Stewart D
- The threat of an AIDS (acquired immune deficiency syndrome) epidemic in the early 1980s saw the emergence of strong negative
- Immunopathogenesis of human gastrointestinal infection by Anisakis simplex.
- Unique Identifier : AIDSLINE MED/99414167 P P
- del Pozo V; Arrieta I; Tunon T; Cortegano I; Gomez B; Cardaba B; Gallardo S; Rojo M
- Gonadotropin-releasing hormone increases CD4 T-lymphocyte numbers in an animal model of immunodeficiency.
- J Allergy Clin Immunol. 1999 Sep;104(3 Pt 1):653-8. Unique Identifier : AIDSLINE MED/99414169
- Jacobson JD; Ansari MA; Mansfield ME; McArthur CP; Clement LT; Section of Endocrinology, Children's Mercy Hospital, University; of Missouri-Kansas City School of Medicine 64108, USA.
- BACKGROUND: Gonadotropin-releasing hormone (GnRH) possesses immunostimulatory properties. We have previously demonstrated that GnRH antagonists decrease lymphocyte numbers in an animal model of autoimmune disease. We speculated that the converse might be true, that GnRH administration would increase lymphocyte numbers
- Pathophysiology of the inflammatory response.
- J Allergy Clin Immunol. 1999 Oct;104(4 Pt 1):S132-7. Unique Identifier : AIDSLINE MED/99449661
- Pearlman DS; University of Colorado Health Sciences Center and the Colorado; Allergy and Asthma Clinic, Aurora, CO 80012-4030, USA.
- Airway allergic reactions enlist diverse cells and a multitude of chemical mediators that are responsible for the clinical symptoms of allergic rhinitis and asthma. Experiments in vitro and in animal models, as well as increasingly numerous studies in atopic human subjects, are revealing that an orchestrated continuum
- Natural history of hepatitis C in HIV-negative patients with congenital coagulation disorders.
- J Hepatol. 1999 Sep;31(3):400-6. Unique Identifier : AIDSLINE MED/99416799
- Meijer K; Haagsma EB; Kok T; Schirm J; Smid WM; van der Meer J; Division of Haemostasis, Thrombosis and Rheology, University; Hospital Groningen, The Netherlands. k.meijer@int.azg.nl
- BACKGROUND/AIMS: Knowledge of the natural history of hepatitis C is useful for counselling patients and planning treatment. More data are needed from unselected patient groups without concomitant disease. The aim of this study was to describe the natural history of hepatitis C, two decades after infection, in a homoge
- Induction and visualization of mucosal memory CD8 T cells following systemic virus infection.
- J Immunol. 1999 Oct 15;163(8):4125-32. Unique Identifier : AIDSLINE MED/99441328
- Kim SK; Schluns KS; Lefrancois L; Division of Rheumatic Diseases, University of Connecticut Health; Center, Farmington 06030, USA.
- Whether CD8 T cell memory exists outside secondary lymphoid organs is unclear. Using an adoptive transfer system that enables tracking of OVA-specific CD8 T cells, we explored the antigenic requirements for inducing CD8 T cell memory and identified intestinal mucosa memory cells. Although systemic immunization with so
- Cytokine requirements for production of a novel anti-CD8-resistant CTL population.
- J Immunol. 1999 Oct 15;163(8):4160-7. Unique Identifier : AIDSLINE MED/99441332
- Lamouse-Smith ES; Dougall DS; McCarthy SA; Immunology Graduate Training Program, Department of Surgery,; University of Pittsburgh School of Medicine, PA 15213, USA.
- A population of CD8+ CTL can be generated in vitro in the presence of anti-CD8 mAb. Due to their apparent high avidity characteristic, these anti-CD8-resistant CD8+ CTL may have important functional in vivo roles in graft rejection, and may be important in antiviral and antitumor responses. We have previously reported
- Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development.
- J Immunol. 1999 Oct 15;163(8):4284-91. Unique Identifier : AIDSLINE MED/99441348
- Skok J; Poudrier J; Gray D; Department of Immunology, Imperial College School of Medicine,; Hammersmith Hospital, London, United Kingdom.
- B cells convert what are normally conditions for Th1 differentiation into an environment suitable for Th2 development. This capacity is dependent on CD40 as B cells from CD40-/- mice do not elicit Th2 differentiation. To elucidate the basis of this effect, we surveyed cytokine RNA made by naive B cells after activatio
- Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.
- J Immunol. 1999 Oct 15;163(8):4335-41. Unique Identifier : AIDSLINE MED/99441354
- Kreuwel HT; Morgan DJ; Krahl T; Ko A; Sarvetnick N; Sherman LA; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.
- CD8+ cytotoxic T cells play a critical role in initiating insulin-dependent diabetes mellitus. The relative contribution of each of the major cytotoxic pathways, perforin/granzyme and Fas/Fas ligand (FasL), in the induction of autoimmune diabetes remains controversial. To evaluate the role of each lytic pathway in bet
- An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.
- J Immunol. 1999 Oct 15;163(8):4421-6. Unique Identifier : AIDSLINE MED/99441364
- Penichet ML; Kang YS; Pardridge WM; Morrison SL; Shin SU; Department of Microbiology, The Molecular Biology Institute,; University of California, Los Angeles 90095, USA.
- In the present study a novel Ab-avidin fusion protein has been constructed to deliver biotinylated compounds across the blood brain barrier. This fusion molecule consists of an Ab specific for the transferrin receptor genetically fused to avidin. The Ab-avidin fusion protein (anti-TfR IgG3-CH3-Av) expressed in murine
- Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand (APO-1L/CD95L).
- J Immunol. 1999 Oct 15;163(8):4462-72. Unique Identifier : AIDSLINE MED/99441369
- Winter H; Hu HM; Urba WJ; Fox BA; Laboratory of Molecular Immunology, Robert W. Franz Cancer; Research Center, Earle A. Chiles Research Institute, Providence; Portland Medical Center, OR 97213, USA.
- The adoptive transfer of tumor-specific effector T cells can result in complete regression and cure mice with systemic melanoma, but the mechanisms responsible for regression are not well characterized. Perforin- and Fas ligand (APO-1/CD95 ligand)-mediated cytotoxicity have been proposed as mechanisms for T cell-media
- TNF is essential for the cell-mediated protective immunity induced by the radiation-attenuated schistosome vaccine.
- J Immunol. 1999 Oct 15;163(8):4489-94. Unique Identifier : AIDSLINE MED/99441372
- Street M; Coulson PS; Sadler C; Warnock LJ; McLaughlin D; Bluethmann H; Wilson RA; Department of Biology, University of York, United Kingdom.; ms31@york.ac.uk
- C57BL/6 mice exposed to the radiation-attenuated schistosome vaccine exhibit high levels of protective immunity. The cell-mediated pulmonary effector mechanism involves IFN-gamma-producing CD4+ T cells in a focal response around challenge larvae. IFN-gamma can promote production of TNF and can synergize with this cyto
- IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii.
- J Immunol. 1999 Oct 15;163(8):4503-9. Unique Identifier : AIDSLINE MED/99441374
- Khan IA; Casciotti L; Department of Medicine, Dartmouth Medical School, Lebanon, NH; 03756, USA. Imtiaz.Khan@dartmouth.edu
- Immunization of mice with a vaccine (ts-4) strain of Toxoplasma gondii is known to induce complete protection against subsequent lethal infection. Ts-4-mediated protection has been reported to be primarily dependent on IFN-gamma-producing CD8+ T cells. However, duration of CD8+ T cell-mediated immunity in the ts-4-vac
- CC chemokine receptor 5 cell-surface expression in relation to CC chemokine receptor 5 genotype and the clinical course of HIV-1 infection.
- J Immunol. 1999 Oct 15;163(8):4597-603. Unique Identifier : AIDSLINE MED/99441385
- de Roda Husman AM; Blaak H; Brouwer M; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of the; Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
- CCR5 cell-surface expression was studied in relation to CCR5 genotype and clinical course of HIV-1 infection. HIV-1 infected CCR5+/+ individuals had higher percentages of CCR5-expressing CD4+ T cells as compared with HIV-1-infected CCR532/+ individuals. For both genotypic groups, the percentages of CCR5-expressing cel
- Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans.
- J Immunol. 1999 Nov 1;163(9):4642-6. Unique Identifier : AIDSLINE MED/99458915
- Huffnagle GB; McNeil LK; McDonald RA; Murphy JW; Toews GB; Maeda N; Kuziel WA; Pulmonary Division, Department of Internal Medicine, University; of Michigan, Ann Arbor 48109, USA. ghuff@umich.edu
- After intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans, 12-wk survival was >90% for CCR5+/+ mice but
- Age-associated rapid and Stat6-independent IL-4 production by NK1-CD4+8- thymus T lymphocytes.
- J Immunol. 1999 Nov 1;163(9):4747-53. Unique Identifier : AIDSLINE MED/99458929
- Chen YT; Chen FL; Kung JT; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan,; Republic of China.
- The source of IL-4 required for priming naive T cells into IL-4-secreting effectors has not been clearly identified. Here we show that upon TCR stimulation, thymus NK1-CD4+8- T cells produced IL-4, the magnitude of which was inversely correlated with age. This IL-4 production response by Th2-prone BALB/c mice was appr
- Selective up-regulation of phosphatidylinositol 3'-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fas-mediated apoptosis.
- J Immunol. 1999 Nov 1;163(9):4772-9. Unique Identifier : AIDSLINE MED/99458932
- Varadhachary AS; Peter ME; Perdow SN; Krammer PH; Salgame P; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.
- In this study the mechanism of differential sensitivity of CD3-activated Th1- and Th2-type cells to Fas-mediated apoptosis was explored. We show that the Fas-associated death domain protein (FADD)/caspase-8 pathway is differentially regulated by CD3 activation in the two subsets. The apoptosis resistance of activated
- CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.
- J Immunol. 1999 Nov 1;163(9):4805-10. Unique Identifier : AIDSLINE MED/99458936
- Honey K; Cobbold SP; Waldmann H; Sir William Dunn School of Pathology, Oxford, United Kingdom.
- The CD40-CD40 ligand (CD40L) interaction is a key event in the initiation of an adaptive immune response, and as such the therapeutic value of CD40L blockade has been studied in many experimental models of tissue transplantation and autoimmune disease. In rodents, transplantation of allogeneic tissues under the cover
- Defective CD8+ T cell activation and cytolytic function in the absence of LFA-1 cannot be restored by increased TCR signaling.
- J Immunol. 1999 Nov 1;163(9):4826-32. Unique Identifier : AIDSLINE MED/99458939
- Shier P; Ngo K; Fung-Leung WP; R. W. Johnson Pharmaceutical Research Institute, San Diego, CA; 92121, USA.
- Signaling through the TCR as well as engagement of costimulatory molecules are required for efficient T cell activation and progression into differentiated effector cells. The beta2 integrin LFA-1 (CD11a/CD18) has been implicated in TCR costimulation as well as in cell-cell adhesion function, but its exact role is sti
- The Th1/Th2 nature of concurrent immune responses to unrelated antigens can be independent.
- J Immunol. 1999 Nov 1;163(9):4842-50. Unique Identifier : AIDSLINE MED/99458941
- Ismail N; Bretscher PA; Department of Microbiology and Immunology, University of; Saskatchewan, Saskatoon, Canada.
- We tested the independence hypothesis, namely that the Th1/Th2 nature of concurrent immune responses, generated in the same secondary lymphoid organ to non-cross-reacting Ags, can be independently determined. Some infectious agents and some adjuvants contain modulatory molecules that affect the Th1/Th2 nature of immun
- An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis.
- J Immunol. 1999 Nov 1;163(9):4970-5. Unique Identifier : AIDSLINE MED/99458957
- Hall LR; Lass JH; Diaconu E; Strine ER; Pearlman E; Division of Geographic Medicine, Department of Medicine, Case; Western Reserve University, University Hospitals of Cleveland, OH; 44106, USA.
- Invasion of the corneal stroma by neutrophils and eosinophils and subsequent degranulation disrupts corneal clarity and can result in permanent loss of vision. In the current study, we used a model of helminth-induced inflammation to demonstrate a novel role for Ab in mediating recruitment of these inflammatory cells
- Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection.
- J Immunol. 1999 Nov 1;163(9):4976-84. Unique Identifier : AIDSLINE MED/99458958
- Brunet LR; Beall M; Dunne DW; Pearce EJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, NY 14853, USA.
- During infection with Schistosoma mansoni, NO production increases following the deposition of parasite eggs in the liver. In wild-type C57BL/6 mice, NO levels peak during the sixth week of infection and are subsequently down-regulated. Inducible NO synthase (iNOS) mRNA was found in diseased liver tissue along with TN
- T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
- J Immunol. 1999 Nov 1;163(9):5020-8. Unique Identifier : AIDSLINE MED/99458963
- Sharma S; Stolina M; Lin Y; Gardner B; Miller PW; Kronenberg M; Dubinett SM; University of California, Los Angeles-Wadsworth Pulmonary; Laboratory, School of Medicine, West Los Angeles Veterans Affairs; Medical Center 90073, USA.
- We have found previously that human lung cancers potently induce T lymphocyte IL-10 production in vitro. To assess the impact of enhanced T cell-derived IL-10 on antitumor immunity in vivo, we utilized transgenic mice expressing IL-10 under the control of the IL-2 prom
- Tissue specificity of E- and P-selectin ligands in Th1-mediated chronic inflammation.
- J Immunol. 1999 Nov 1;163(9):5086-93. Unique Identifier : AIDSLINE MED/99458971
- Chu A; Hong K; Berg EL; Ehrhardt RO; Protein Design Laboratories, Inc., Fremont, CA 94555, USA.
- The demonstrated role of E- and P-selectin ligands in the recruitment of Th1 cells raises the question of tissue specificity determination by pathogenic T cells. We took advantage of the fact that chronic Th1-mediated inflammation in the scid/scid CD4+CD45RBhigh T cell transfer model can occur at multiple tissue sites
- Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.
- J Immunol. 1999 Nov 1;163(9):5116-24. Unique Identifier : AIDSLINE MED/99458974
- Aronica MA; Mora AL; Mitchell DB; Finn PW; Johnson JE; Sheller JR; Boothby MR; Division of Allergy, Pulmonary, and Critical Care Medicine,; Department of Medicine, Vanderbilt University Medical School,; Nashville, TN 37232, USA.
- T cell function is a critical determinant of immune responses as well as susceptibility to allergic diseases. Activated T cells can differentiate into effectors whose cytokine profile is limited to type 1 (IFN-gamma-dominant) or type 2 (IL-4-, IL-5-dominant) patterns. To investigate mechanisms that connect extracellul
- Infection of circulating CD34+ cells by HHV-8 in patients with Kaposi's sarcoma.
- J Invest Dermatol. 1999 Oct;113(4):613-6. Unique Identifier : AIDSLINE MED/99436245
- Henry M; Uthman A; Geusau A; Rieger A; Furci L; Lazzarin A; Lusso P; Tschachler E; Division of Immunology, Allergy and Infectious Diseases,; Department of Dermatology, Vienna Medical School, Austria.
- Human herpesvirus type 8 (HHV-8) has been identified as the most likely candidate to be involved in the development of Kaposi s Sarcoma (KS). HHV-8 has been associated with all forms of KS, primary effusion lymphoma, and multicentric Castleman s disease and detected in various non-neoplastic cells. Its presence in cel
- Expression of the CD4+ cell-specific chemoattractant interleukin-16 in mycosis fungoides.
- J Invest Dermatol. 1999 Oct;113(4):658-63. Unique Identifier : AIDSLINE MED/99436252
- Blaschke V; Reich K; Middel P; Letschert M; Sachse F; Harwix S; Neumann C; Department of Dermatology, Georg-August-University, Gottingen,; Germany. vblasch@gwdg.de
- Interleukin-16 is a soluble ligand to the CD4 molecule with chemotactic properties for CD4+ cells and a competence growth factor for CD4+ T cells, upregulating HLA-DR and the interleukin-2 receptor CD25. There is also evidence for a synergistic effect of interleukin-16 and interleukin-2 on the activation of CD4+ T cel
- Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma.
- J Infect Dis. 1999 Oct;180(4):1010-7. Unique Identifier : AIDSLINE MED/99408819
- O'Brien TR; Kedes D; Ganem D; Macrae DR; Rosenberg PS; Molden J; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, EPS 8016,; Rockville, MD 20852, USA. obrient@exchange.nih.gov; obrient@exchange.nih.gov
- We examined human herpesvirus 8 (HHV-8) seroprevalence and seroincidence among 245 homosexual men from New York City (NYC) and Washington, DC (DC) who have been followed since 1982. An immunofluorescence assay measured antibodies to a latent HHV-8 nuclear antigen. Seroprevalence was 20.4% in 1982; seroincidence was ap
- Longitudinal human immunodeficiency virus type 1 load in the italian seroconversion study: correlates and temporal trends of virus load.
- J Infect Dis. 1999 Oct;180(4):1018-24. Unique Identifier : AIDSLINE MED/99408820
- Lyles CM; Dorrucci M; Vlahov D; Pezzotti P; Angarano G; Sinicco A; Alberici F; Alcorn TM; Vella S; Rezza G; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland, USA.
- A prospective study of 149 human immunodeficiency virus type 1 (HIV-1) seroconverters was conducted to describe trends and correlates of HIV-1 load after seroconversion and over time. HIV-1 load was quantified from frozen sera by reverse transcriptase-polymerase chain reaction. High early virus load was associated wit
- The effect of drug-injection behavior on genetic evolution of HIV-1.
- J Infect Dis. 1999 Oct;180(4):1025-32. Unique Identifier : AIDSLINE MED/99408821
- Carneiro M; Yu XF; Lyles C; Templeton A; Weisstein AE; Safaeian M; Farzadegan H; Vlahov D; Markham RB; Universidade Federal de Minas Gerais, Departamento de; Parasitologia-Epidemiologia, Caixa Postal-486, Belo Horizonte, MG; 31270-901, Brazil.
- The effect of injection-drug use on human immunodeficiency virus type 1 (HIV-1) env genetic evolution was examined in 15 seroconverting injection-drug users followed up for 4 years. After adjustment for non-drug-related independent variables significantly associated with genetic diversity (time since seroconversion an
- Viral and immunologic examination of human immunodeficiency virus type 1-infected, persistently seronegative persons.
- J Infect Dis. 1999 Oct;180(4):1033-42. Unique Identifier : AIDSLINE MED/99408822
- Ellenberger DL; Sullivan PS; Dorn J; Schable C; Spira TJ; Folks TM; Lal RB; HIV/AIDS Branch, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA. dxe1@cdc.gov
- Persons who were human immunodeficiency virus type 1 (HIV-1)-infected but who remained persistently seronegative (HIPS) on HIV-1 antibody tests were examined through AIDS case surveillance. Six such individuals (HIPS-1 to -4, -7, and -9) were examined to determine whether their persistent seronegativity was attributab
- Sequence clusters in human immunodeficiency virus type 1 reverse transcriptase are associated with subsequent virological response to antiretroviral therapy.
- J Infect Dis. 1999 Oct;180(4):1043-9. Unique Identifier : AIDSLINE MED/99408823
- Brown AJ; Gunthard HF; Wong JK; D'Aquila RT; Johnson VA; Kuritzkes DR; Richman DD; Centre for HIV Research, University of Edinburgh, Edinburgh EH9; 3JN, Scotland. A.Leigh-Brown@ed.ac.uk
- Many amino acid (aa) sites in reverse transcriptase (RT) have been implicated in resistance to nucleoside (NRTI) and nonnucleoside antiretrovirals. Interactions between these in response to combination therapy remain poorly understood. In a trial (ACTG 241) of zidovudi
- Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults.
- J Infect Dis. 1999 Oct;180(4):1050-6. Unique Identifier : AIDSLINE MED/99408824
- Notermans DW; Pakker NG; Hamann D; Foudraine NA; Kauffmann RH; Meenhorst PL; Goudsmit J; Roos MT; Schellekens PT; Miedema F; Danner SA; National AIDS Therapy Evaluation Centre (NATEC), Academic Medical; Centre, 1100 DE, Amsterdam, The Netherlands.; D.W.Notermans@amc.uva.nl
- Today s antiretroviral combination regimens can induce significant and sustained decreases in human immunodeficiency virus (HIV)-RNA levels, allowing the immune system to recover. To what extent immune reconstitution is possible and what factors determine the outcome have thus far not been resolved. We studied 19 subj
- Restoration of normal interleukin-2 production by CD4+ T cells of human immunodeficiency virus-infected patients after 9 months of highly active antiretroviral therapy.
- J Infect Dis. 1999 Oct;180(4):1057-63. Unique Identifier : AIDSLINE MED/99408825
- Weiss L; Ancuta P; Girard PM; Bouhlal H; Roux A; Cavaillon NH; Kazatchkine MD; INSERM U 430, Hopital Broussais, 75014, Paris, France. laurence.; weiss@brs.ap-hop-paris.fr
- The present study investigated immune restoration in patients at intermediate stages of human immunodeficiency virus (HIV) disease after initiation of highly active antiretroviral therapy (HAART). A progressive increase in both memory and naive CD4+ T cells was observed from the first weeks of therapy, concomitant wit
- The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial.
- J Infect Dis. 1999 Oct;180(4):1064-71. Unique Identifier : AIDSLINE MED/99408826
- Skowron G; Stein D; Drusano G; Melbourne K; Bilello J; Mikolich D; Rana K; Agosti JM; Mongillo A; Whitmore J; Gilbert MJ; Division of Infectious Diseases, Roger Williams Medical Center,; Providence, RI 02908, USA. Gail_Skowron@brown.edu
- Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection. Its safety and activity when used in combination with protease inhibitors were evaluated i
- Polyspecific self-reactive antibodies in individuals infected with human immunodeficiency virus facilitate T cell deletion and inhibit costimulatory accessory cell function.
- J Infect Dis. 1999 Oct;180(4):1072-9. Unique Identifier : AIDSLINE MED/99408827
- Wang Zq; Horowitz HW; Orlikowsky T; Hahn BI; Trejo V; Bapat AS; Mittler RS; Rayanade RJ; Yang SY; Hoffmann MK; Departments of Microbiology, Immunology, New York Medical; College, New York, USA.
- Self-reactive polyspecific IgG antibodies (PSAs) arise in human immunodeficiency virus (HIV)-seropositive subjects before they develop AIDS. Self-reactive PSA levels correlate with the destruction of CD8 T cells in HIV-infected individuals and mediate the antibody-dependent cellular toxicity-based destruction of human
- Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women.
- J Infect Dis. 1999 Oct;180(4):1080-8. Unique Identifier : AIDSLINE MED/99408828
- Wright PF; Lambert JS; Gorse GJ; Hsieh RH; McElrath MJ; Weinhold K; Wara DW; Anderson EL; Keefer MC; Jackson S; Wagner LJ; Francis DP; Fast PE; McNamara J; Division of Pediatric Infectious Disease, Vanderbilt University; Medical Center, Nashville, Tennessee 37232, USA.; peter.wright@mcmail. vanderbilt.edu
- Twenty-six human immunodeficiency virus (HIV)-infected pregnant women participated in a placebo-controlled study of immunogenicity and safety of multiple doses of MN rgp120 vaccine over the last half of pregnancy. The women had CD4 lymphocyte counts>400/mm3, no AIDS-defining illness and normal pregnancies. Vaccination
- Prospective evaluation of amplification-boosted ELISA for heat-denatured p24 antigen for diagnosis and monitoring of pediatric human immunodeficiency virus type 1 infection.
- J Infect Dis. 1999 Oct;180(4):1089-95. Unique Identifier : AIDSLINE MED/99408829
- Nadal D; Boni J; Kind C; Varnier OE; Steiner F; Tomasik Z; Schupbach J; Pediatric Infectious Diseases Unit, Universitats-Kinderklinik,; CH-8032 Zurich, Switzerland. dnadal@kispi.unizh.ch
- The performance in pediatric human immunodeficiency virus type 1 (HIV-1) infection of a signal-amplification boosted ELISA for HIV-1 p24 antigen in plasma after heat-mediated immune complex dissociation was prospectively compared with polymerase chain reaction-based procedures. Diagnostic sensitivity and specificity o
- Chemokine receptor polymorphisms and human immunodeficiency virus disease progression.
- J Infect Dis. 1999 Oct;180(4):1096-105. Unique Identifier : AIDSLINE MED/99408830
- Easterbrook PJ; Rostron T; Ives N; Troop M; Gazzard BG; Rowland-Jones SL; Dept. of HIV Medicine, Weston Education Centre, The Guy's,; King's, London SE5 9RT, United Kingdom.; philippa.easterbrook@kcl.ac.uk
- The role of polymorphisms in genes encoding chemokines and their receptors (CCR2B, SDF-1, and the promoter region of CCR5) in human immunodeficiency virus (HIV) disease progression was studied in 132 white HIV type 1 (HIV-1)-infected participants from a United Kingdom cohort study. Gen
- Adaptation to promiscuous usage of chemokine receptors is not a prerequisite for human immunodeficiency virus type 1 disease progression.
- J Infect Dis. 1999 Oct;180(4):1106-15. Unique Identifier : AIDSLINE MED/99408831
- de Roda Husman AM; van Rij RP; Blaak H; Broersen S; Schuitemaker H; Department of Clinical Viro-Immunology, CLB, Laboratory for; Experimental and Clinical Immunology, University of Amsterdam,; Academic Medical Center, Amsterdam, The Netherlands.
- Fifty percent of individuals infected with human immunodeficiency virus type 1 (HIV-1) progress to AIDS in the presence of only non-syncytium-inducing (NSI) variants. These rapidly replicating NSI isolates are associated with a high viral load. The question of whether disease progression in the absence of syncytium-in
- Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2.
- J Infect Dis. 1999 Oct;180(4):1116-21. Unique Identifier : AIDSLINE MED/99408832
- Popper SJ; Sarr AD; Travers KU; Gueye-Ndiaye A; Mboup S; Essex ME; Kanki PJ; Department of Immunology, Harvard AIDS Institute, Harvard School; of Public Health, Boston, Massachusetts, USA.
- Human immunodeficiency virus type 2 (HIV-2) is less pathogenic than HIV type 1 (HIV-1), but the mechanisms underlying this difference have not been defined. We developed an internally controlled quantitative reverse transcriptase-polymerase chain reaction to measure HIV-2 viral load and determined levels of plasma vir
- Efficient human immunodeficiency virus ( HIV)-1 Gag-Env pseudovirion formation elicited from mammalian cells by a canarypox HIV vaccine candidate.
- J Infect Dis. 1999 Oct;180(4):1122-32. Unique Identifier : AIDSLINE MED/99408833
- Fang ZY; Kuli-Zade I; Spearman P; Department of Pediatrics, Vanderbilt University School of; Medicine, Nashville, Tennessee 37232-2581 USA.
- Canarypox viruses undergo abortive replication in mammalian cells. Despite this restriction on replication in mammalian cells, significant immune responses have been shown in animals and in humans receiving recombinant canarypox vaccine vectors expressing heterologous immunogens. A recombinant canarypox vaccine candid
- Decline of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in the peripheral blood of long-term nonprogressing macaques infected with SIVmac32H-J5.
- J Infect Dis. 1999 Oct;180(4):1133-41. Unique Identifier : AIDSLINE MED/99408834
- Geretti AM; Hulskotte EG; Dings ME; van Baalen CA; van Amerongen G; Norley SG; Boers P; Gruters R; Osterhaus AD; Institute of Virology, Erasmus University, Rotterdam, The; Netherlands. geretti@rfhsm.ac.uk
- The evolution of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocyte precursors (CTLps) and their relationship with virus replication were studied in SIV-infected macaques. After primary viremia, 3 of 8 macaques lost culturable virus and polymerase chain reaction-detectable provirus in peripheral blood
- Involvement of matrix metalloproteinases in human immunodeficiency virus type 1-induced replication by clinical Mycobacterium avium isolates.
- J Infect Dis. 1999 Oct;180(4):1142-52. Unique Identifier : AIDSLINE MED/99408835
- Dezzutti CS; Swords WE; Guenthner PC; Sasso DR; Wahl LM; Drummond AH; Newman GW; King CH; Quinn FD; Lal RB; HIV and Retrovirus Diseases Branch, Centers for Disease control; and Prevention, Atlanta, Georgia, USA. cyd5@cdc.gov
- The role of Mycobacterium avium isolates in modulating human immunodeficiency virus type 1 (HIV-1) replication was examined by use of an in vitro, resting T cell system. Two human clinical isolates (serotypes 1 and 4) but not an environmental M. avium isolate (serotype 2) enhanced HIV-1 replication. The M. avium-induc
- Suppression of acquired immunity against Listeria monocytogenes by amphotericin B-mediated inhibition of CD8 T cell function.
- J Infect Dis. 1999 Oct;180(4):1186-94. Unique Identifier : AIDSLINE MED/99408841
- Geginat G; Kretschmar M; Walter S; Junker D; Hof H; Nichterlein T; Institut fur Medizinische Mikrobiologie und Hygiene, Fakultat; fur Klinische Medizin Mannheim der Universitat Heidelberg,; 68167 Mannheim, Germany.
- Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes-immune mice with a
- Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men.
- J Infect Dis. 1999 Oct;180(4):1245-51. Unique Identifier : AIDSLINE MED/99408848
- Yaganehdoost A; Graviss EA; Ross MW; Adams GJ; Ramaswamy S; Wanger A; Frothingham R; Soini H; Musser JM; Institute for the Study of Human Bacterial Pathogenesis, Baylor; College of Medicine, Houston, TX, USA.
- Limited data suggest that measures to reduce tuberculosis transmission should be based on locations rather than on personal contacts. Molecular epidemiologic methods (analysis of IS6110 patterns, spoligotypes, variable numbers of tandem DNA repeats, and automated DNA sequence data) identified a cohort of 48 persons wh
- Use of a hybrid capture assay of self-collected vaginal swabs in rural Uganda for detection of human papillomavirus.
- J Infect Dis. 1999 Oct;180(4):1316-9. Unique Identifier : AIDSLINE MED/99408857
- Serwadda D; Wawer MJ; Shah KV; Sewankambo NK; Daniel R; Li C; Lorincz A; Meehan MP; Wabwire-Mangen F; Gray RH; Institute of Public Health, Faculty of Medicine, Makerere; University, Kampala, Uganda.
- A random sample of 960 women aged 15-59 years enrolled in a population-based study in rural Uganda were asked to provide self-collected vaginal swabs for human papillomavirus (HPV) testing by hybrid capture assay. The intensity of HPV infection was assessed by the relative light un
- Prenatal diagnostic and prognostic value of human cytomegalovirus load and IgM antibody response in blood of congenitally infected fetuses.
- J Infect Dis. 1999 Oct;180(4):1320-3. Unique Identifier : AIDSLINE MED/99408858
- Grazia Revello M; Zavattoni M; Sarasini A; Baldanti F; De Julio C; De-Giuli L; Nicolini U; Gerna G; Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia,; Italy. virology@ipv36.unipv.it
- Human cytomegalovirus (HCMV) load and virus-specific IgM were quantified in blood of 36 fetuses from mothers with primary HCMV infection. Nineteen fetuses were congenitally infected and 17 were uninfected as diagnosed by virus isolation from and DNA detection in amniotic fluid. Sen
- Hepatitis G virus and human immunodeficiency virus coinfection: response to interferon-alpha therapy.
- J Infect Dis. 1999 Oct;180(4):1334-7. Unique Identifier : AIDSLINE MED/99408861
- Lau DT; Miller KD; Detmer J; Kolberg J; Herpin B; Metcalf JA; Davey RT; Hoofnagle JH; Liver Diseases Section, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland, USA.
- The prevalence and consequences of hepatitis G virus (HGV) infection were determined in 180 patients with human immunodeficiency virus (HIV) infection (predominantly male homosexuals) who participated in a trial that compared treatment with zidovudine versus interferon (IFN)-alpha versus the combination. HGV RNA level
- Antibody-dependent cellular cytotoxicity independently predicts survival in severely immunocompromised human immunodeficiency virus-infected patients.
- J Infect Dis. 1999 Oct;180(4):1338-41. Unique Identifier : AIDSLINE MED/99408862
- Forthal DN; Landucci G; Haubrich R; Keenan B; Kuppermann BD; Tilles JG; Kaplan J; Division of Infectious Diseases, Department of Medicine,; University of California, Irvine, Orange, CA 92868, USA.; dnfortha@uci.edu
- The exact immune defects leading to human immunodeficiency virus (HIV)-associated opportunistic infections, malignancies, and death are unknown. In this study, the relationship between survival and 2 immune functions, cytomegalovirus-specific antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) acti
- Highly active antiretroviral treatment initiated early in the course of symptomatic primary HIV-1 infection: results of the ANRS 053 trial.
- J Infect Dis. 1999 Oct;180(4):1342-6. Unique Identifier : AIDSLINE MED/99408863
- Hoen B; Dumon B; Harzic M; Venet A; Dubeaux B; Lascoux C; Bourezane Y; Ragnaud JM; Bicart-See A; Raffi F; Beauvais L; Fleury H; Sereni D; Service de Maladies Infectieuses et Tropicales, CHU de; Besancon-Hopital Saint-Jacques, F-25030 Besancon Cedex, France.; bruno.hoen@univ-fcomte.fr
- Highly active antiretroviral treatment (HAART) was given early to 64 patients with symptomatic primary human immunodeficiency virus (HIV)-1 infection. At the time of analysis, patients had been followed up for 9-21 months. No patient had died or developed an AIDS-defining event. Survival analysis showed that by month
- Suppression of plasma virus load below the detection limit of a human immunodeficiency virus kit is associated with longer virologic response than suppression below the limit of quantitation.
- J Infect Dis. 1999 Oct;180(4):1347-50. Unique Identifier : AIDSLINE MED/99408864
- Raboud JM; Rae S; Hogg RS; Yip B; Sherlock CH; Harrigan PR; O'Shaughnessy MV; Montaner JS; Data and Methodology Program, Canadian HIV Trials Network,; Vancouver, Canada.
- Suppression of human immunodeficiency virus type 1 plasma virus load (PVL) to
- Systemic and mucosal immunity is elicited after both intramuscular and intravaginal delivery of human immunodeficiency virus type 1 DNA plasmid vaccines to pregnant chimpanzees.
- J Infect Dis. 1999 Oct;180(4):1351-5. Unique Identifier : AIDSLINE MED/99408865
- Bagarazzi ML; Boyer JD; Javadian MA; Chattergoon MA; Shah AR; Cohen AD; Bennett MK; Ciccarelli RB; Ugen KE; Weiner DB; MCP Hahnemann University, Department of Pediatrics, St.; Christopher's Hospital for Children, Philadelphia, PA 19134, USA.; mark.bagarazzi@drexel.edu
- DNA vaccines encoding human immunodeficiency virus type 1 (HIV-1) env/rev and gag/pol were delivered intravaginally (IVAG) and intramuscularly (IM) to 2 pregnant chimpanzees. Vaccination was well tolerated and each chimpanzee developed antibodies (up to 1 year later) to both vaccines. Placental transfer of anti-Env an
- Absence of Kaposi's sarcoma-associated herpesvirus DNA in bacillary angiomatosis-peliosis lesions.
- J Infect Dis. 1999 Oct;180(4):1386-9. Unique Identifier : AIDSLINE MED/99408873
- Relman DA; Fredricks DN; Yoder KE; Mirowski G; Berger T; Koehler JE; Veterans Affairs Palo Alto Health Care System 154T, Palo Alto, CA; 94304, USA. relman@cmgm.stanford.edu
- Bartonella henselae and B. quintana induce an unusual vascular proliferative tissue response known as bacillary angiomatosis (BA) and bacillary peliosis (BP) in some human hosts. The mechanisms of Bartonella-associated vascular proliferation remain unclear. Although host fact
- Cytotoxic T lymphocyte precursors in persons with repeated exposure to human immunodeficiency virus [letter]
- J Infect Dis. 1999 Oct;180(4):1406-7. Unique Identifier : AIDSLINE MED/99408878
- Forthal DN
- Influence of hepatitis C virus (HCV) genotype, HCV RNA load, and alanine aminotransferase level on reduction of HCV RNA after a single administration of interferon-alpha [letter; comment]
- J Infect Dis. 1999 Oct;180(4):1411-2. Unique Identifier : AIDSLINE MED/99408884
- Antonelli G; Riva E; Maggi F; Vatteroni ML; Simeoni E
- Cryptococcosis and smoking: the potential role of iron [letter; comment]
- J Infect Dis. 1999 Oct;180(4):1412-3. Unique Identifier : AIDSLINE MED/99408885
- Boelaert JR; Blasi E
- Partial nucleotide sequencing and molecular evolution of epidemic causing Dengue 2 strains.
- J Infect Dis. 1999 Oct;180(4):959-65. Unique Identifier : AIDSLINE MED/99408812
- Singh UB; Maitra A; Broor S; Rai A; Pasha ST; Seth P; Department of Microbiology, All India Institute of Medical; Sciences, Ansari Nagar, New Delhi-110029, India.; urvashib@medinst_ernet_in
- To study the genetic variability and to detect evolutionary changes and movement of dengue 2 (DEN-2) strains, nucleotide sequencing of the envelope protein gene and the nonstructural protein 1 gene junction was performed for 9 isolates from the 1996 Delhi epidemic and 1 isolate from the 1967 Delhi epidemic. The epidem
- Clinicians' perceptions of barriers to pain management in AIDS.
- J Pain Symptom Manage. 1999 Sep;18(3):203-12. Unique Identifier : AIDSLINE MED/99446239
- Breitbart W; Kaim M; Rosenfeld B; Department of Psychiatry and Behavioral Sciences, Memorial; Sloan-Kettering Cancer Center, New York, New York 10021, USA.
- A growing body of literature has demonstrated the widespread undertreatment of pain in patients with AIDS. While clinician-related barriers to cancer pain management have been studied, to date there has been no systematic attempt to survey clinician-related barriers to the management of pain in patients with AIDS. We
- Symptom prevalence, characteristics, and distress in AIDS outpatients.
- J Pain Symptom Manage. 1999 Oct;18(4):253-62. Unique Identifier : AIDSLINE MED/20004865
- Vogl D; Rosenfeld B; Breitbart W; Thaler H; Passik S; McDonald M; Portenoy RK; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, New York, USA.
- Symptom distress is an important but poorly characterized aspect of quality of life in AIDS patients. To assess and characterize the symptoms and symptom distress associated with AIDS, 504 ambulatory patients with AIDS were evaluated between December, 1992 and December, 1995. The assessment included measures of sympto
- Physicians' recognition of the symptoms experienced by HIV patients: how reliable?
- J Pain Symptom Manage. 1999 Oct;18(4):263-70. Unique Identifier : AIDSLINE MED/20004866
- Fontaine A; Larue F; Lassauniere JM; Departement de Sante Publique, Faculte Bichat, Universite; Paris VII, France.
- To assess how well physicians recognize common symptoms in HIV patients and identify factors associated with symptom recognition, a multicenter cross-sectional survey was performed in a random sample of 118 hospitalized and 172 ambulatory HIV patients, and their attending physicians. Patients reports of 16 different
- Lymphoepithelial cyst of the pancreas. No evidence for Epstein-Barr virus-related pathogenesis.
- Int J Pancreatol. 1999 Jun;25(3):223-7. Unique Identifier : AIDSLINE MED/99382796
- Schwarz RE; Weiss LM; Department of General Oncologic Surgery, City of Hope National; Medical Center, Duarte, CA 91010-3000, USA.; RSchwarz@smtplink.coh.org
- Compared to pseudocyst formation after prior pancreatitis, true cysts of the pancreas are rare. Pancreatic cysts with irregular wall components or a mucinous content raise the suspicion for the presence of a cystic neoplasm, and surgical resection is recommended. A case of a patient with a history of prostate cancer i
- A population model applied to HIV transmission considering protection and treatment.
- IMA J Math Appl Med Biol. 1999 Sep;16(3): O: 099 M: I: 515. Unique Identifier : AIDSLINE MED/99450209
- Yang HM; Ferreira Junior WC; Universidade Estadual de Campinas, IMECC, Departamento Matematica; Aplicada, SP, Brazil. hyunyang@ime.unicamp.br
- An epidemiological population model is proposed to assess the impact of protection and/or treatment strategies applied to HIV infection. Sex-education campaigns are the available protection strategy, and drug (or association of drugs) administration is the treatment strategy considered. In this model we assumed recrui
- Chronic low-dose gamma-radiation exposure and the alteration of the distribution of lymphocyte subpopulations in residents of radioactive buildings.
- Int J Radiat Biol. 1999 Oct;75(10):1231-9. Unique Identifier : AIDSLINE MED/20015792
- Chang WP; Hwang JS; Hung MC; Hu TH; Lee SD; Hwang BF; Institute of Environmental Health Sciences, National Yang Ming; University Medical School, Department of Family Medicine, Taipei; Municipal Jan-Ai Hospital, Taiwan.
- PURPOSE: To elucidate the immunological change incurred in a human population by protracted gamma-radiation exposure at home environment. MATERIALS AND METHODS: An examination on the CD3+, CD4+, CD8+ and HLA-DR+ lymphocyte subsets was arranged for 196 exposed subjects with mean excess cumulative dose of 169 mSv during
- Can we get AIDS from mosquito bites?
- J La State Med Soc. 1999 Aug;151(8):429-33. Unique Identifier : AIDSLINE MED/20022130
- Iqbal MM; Department of Epidemiology, School of Public Health, University; of Alabama at Birmingham, USA.
- Human immunodeficiency virus, or HIV, is a human retrovirus that infects lymphocytes and other cells bearing the CD4 surface marker. The virus is transmitted primarily by sexual and parental routes. There are two ways blood feeding arthropods can spread disease, mechanically, by simple transfer of virus between hosts
- Therapeutic effect of glucocorticoid on experimental crescentic glomerulonephritis.
- J Lab Clin Med. 1999 Oct;134(4):410-8. Unique Identifier : AIDSLINE MED/99449399
- Yamamoto-Shuda Y; Nakayama K; Saito T; Natori Y; Research Institute, International Medical Center of Japan, Tokyo.
- Crescentic glomerulonephritis shows active and progressive glomerular changes with rapid deterioration in kidney function. A large dose of glucocorticoid (pulse therapy) is clinically used for the treatment, but its efficacy has not been fully estimated. In this study we assessed the therapeutic effect of a large dose
- The actions of bacterial DNA on murine macrophages.
- J Leukoc Biol. 1999 Oct;66(4):542-8. Unique Identifier : AIDSLINE MED/20001673
- Sester DP; Stacey KJ; Sweet MJ; Beasley SJ; Cronau SL; Hume DA; Centre for Molecular and Cellular Biology, and Department of; Microbiology, University of Queensland, Australia.
- Murine macrophages are able to distinguish bacterial from mammalian DNA. The response is mimicked by single-stranded oligonucleotides containing unmethylated CG dinucleotides ( CpG motifs) in specific sequence contexts. The dose-response curve for activation is influenced by variation in the sequence flanking the cor
- A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial.
- J Med. 1998;29(5-6):305-30. Unique Identifier : AIDSLINE MED/99432784
- Gordon M; Bihari B; Goosby E; Gorter R; Greco M; Guralnik M; Mimura T; Rudinicki V; Wong R; Kaneko Y; AIDS Activities Division, San Francisco General Hospital, CA,; USA.
- Lentinan is a beta 1-->3 glucan isolated from Lentinus edodes (Shiitake mushroom) which has immune modulating properties. We have conducted two phase I/II placebo-controlled trials on a total of 98 patients. In one study at the San Francisco General Hospital (SFGH), ten patients each were administered 2, 5, or 10 mg o
- Aortic reconstruction in the HIV infected patient.
- J Med. 1999;30(1-2):122-6. Unique Identifier : AIDSLINE MED/99443271
- Silva MB Jr; Simonian GT; Gilani A; Pappas PJ; Hobson RW 2nd; Department of Surgery, UMDNJ-New Jersey Medicial School, Newark; 07103-2714, USA.
- Major vascular reconstruction using prosthetic implantation is uncommon in the HIV infected patient. We describe a 52-year-old man with HIV infection and HIV-induced thrombocytopenia, who underwent successful aorto-bifemoral bypass for lower extremity ischemic symptoms. Postoperative progressive thrombocytopenia and s
- Pulmonary nodule mimicking lung cancer in a human immunodeficiency virus type-1 infected patient.
- J Med. 1999;30(1-2):93-9. Unique Identifier : AIDSLINE MED/99443268
- Takahashi T; Endou T; Nakamura T; Asai S; Yoshikawa K; Iwamoto A; Department of Infectious Diseases, Institute of Medical Science,; University of Tokyo, Japan. takahata@ims.u-tokyo.ac.jp
- We reported a human immunodeficiency virus type 1-infected patient with a small solitary pulmonary nodule mimicking adenocarcinoma, who was treated successfully with antituberculosis therapy. We believe that high-resolution CT scans of thorax are important examinations to detect pulmonary inflammatory findings, such a
- Prevalence of disseminated Mycobacterium avium complex infection in Thai AIDS patients.
- J Med Assoc Thai. 1999 Jul;82(7):643-7. Unique Identifier : AIDSLINE MED/99441435
- Chuchottaworn C; Sathapatayawongs B; Tansuphsawadikul S; Suwanagool S; Kantipong P; Pornchaipoonthavee S; Department of Medicine, Central Chest Hospital, Ministry of; Public Health, Nonthaburi.
- Infections caused by nontuberculous mycobacteria (NTM), although rare in immuno-competent individuals, can potentially produce problems in immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS). In this study, hemocultures for mycobacteria using radiometric BACTEC 13A media were taken
- Giardia lamblia in AIDS patients with diarrhea.
- J Med Assoc Thai. 1999 Jul;82(7):654-9. Unique Identifier : AIDSLINE MED/99441437
- Moolasart P; WHO Collaborating Centre on HIV/AIDS, Bamrasnaradura Infectious; Disease Hospital, Department of Communicable Disease Control,; Nonthaburi, Thailand.
- Giardia lamblia, a flagellate protozoan is a protozoa, frequently associated with diarrhea in AIDS patients (adults and children). Transmission occurs via the fecal-oral route by ingestion of infectious cysts in contaminated food or drinking water. Giardia lamblia can cause diarrhea and intestinal malabsorption in bot
- Thai language skill and HIV counseling among hilltribe people: a hospital-based study in Chiang Rai.
- J Med Assoc Thai. 1999 Aug;82(8):808-11. Unique Identifier : AIDSLINE MED/99441461
- Apisitsaowapa Y; Prasit V; Jongsakul K; Kantipong P; Watt G; Brown AE; Department of Retrovirology, U.S. Army Component, Armed Forces; Research Institute of Medical Science (AFRIMS), Bangkok,; Thailand.
- Twenty-nine hilltribe individuals from 6 different ethnic groups were among a group of 70 patients included in an investigation of interactions between HIV-1 virus infection and common tropical illnesses. Approximately half of the hilltribe subjects (14/29) required the aid of an interpreter for HIV counseling because
- Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice.
- J Exp Med. 1999 Oct 4;190(7):1013-24. Unique Identifier : AIDSLINE MED/99439782
- Haynes L; Linton PJ; Eaton SM; Tonkonogy SL; Swain SL; Trudeau Institute, Saranac Lake, New York 12983, USA.; lhaynes@trudeauinstitute.org
- Development of effectors from naive CD4 cells occurs in two stages. The early stage involves activation and limited proliferation in response to T cell receptor (TCR) stimulation by antigen and costimulatory antigen presenting cells, whereas the later stage involves proliferation and differentiation in response to gro
- The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors [see comments]
- J Exp Med. 1999 Oct 4;190(7):1025-32. Unique Identifier : AIDSLINE MED/99439783
- Djerbi M; Screpanti V; Catrina AI; Bogen B; Biberfeld P; Grandien A; Department of Immunology, Wenner-Gren Institute, University of; Stockholm, S-10691 Stockholm, Sweden.
- Death receptor-mediated apoptosis can be modulated by several antiapoptotic proteins, such as the FLICE (FADD [Fas-associated death domain]-like IL-1beta-converting enzyme)-inhibitory proteins (FLIPs). The FLIP family includes both cellular and viral members. The Kaposi s sarcoma-associated herpesvirus protein (KSHV)-
- Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.
- J Exp Med. 1999 Oct 4;190(7):895-902. Unique Identifier : AIDSLINE MED/99439770
- Coyle AJ; Lloyd C; Tian J; Nguyen T; Erikkson C; Wang L; Ottoson P; Persson P; Delaney T; Lehar S; Lin S; Poisson L; Meisel C; Kamradt T; Bjerke T; Levinson D; Gutierrez-Ramos JC; Department of Biology, Inflammation Division, Millennium; Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.; coyle@mpi.com
- T1/ST2 is an orphan receptor of unknown function that is expressed on the surface of murine T helper cell type 2 (Th2), but not Th1 effector cells. In vitro blockade of T1/ST2 signaling with an immunoglobulin (Ig) fusion protein suppresses both differentiation to and activation of Th2, but not Th1 effector populations
- Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.
- Unique Identifier : AIDSLINE MED/99439776
- Artis D; Humphreys NE; Bancroft AJ; Rothwell NJ; Potten CS; Grencis RK; Immunology Group, School of Biological Sciences, University of; Manchester, Manchester M13 9PT, United Kingdom.; mqbsszda@man.ac.uk
- In vivo manipulation of cytokine and/or cytokine receptor expression has previously shown that resistance to infection with the caecum-dwelling helminth Trichuris muris is dependent on interleukin (IL)-4 and IL-13 while susceptibility is associated with a T helper cell type 1 (Th1) cytokine response. Using gene-target
- A defect in interleukin 12-induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus.
- J Exp Med. 1999 Oct 4;190(7):963-72. Unique Identifier : AIDSLINE MED/99439777
- Falcone M; Yeung B; Tucker L; Rodriguez E; Sarvetnick N; Department of Immunology, The Scripps Research Institute, La; Jolla, California 92037, USA.
- The function of natural killer T (NKT) cells in the immune system has yet to be determined. There is some evidence that their defect is associated with autoimmunity, but it is still unclear how they play a role in regulating the pathogenesis of T cell-mediated autoimmune diseases. It was originally proposed that NKT c
- An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.
- Unique Identifier : AIDSLINE MED/99439780
- Asseman C; Mauze S; Leach MW; Coffman RL; Powrie F; Nuffield Department of Surgery, John Radcliffe Hospital,; University of Oxford, Oxford OX3 9DU, United Kingdom.
- A T helper cell type 1-mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RB(high) CD4(+) T cells and can be prevented by cotransfer of the CD45RB(low) subset. The immune-suppressive activities of the CD45RB(low) T cell population can be reversed in vivo by administration of an ant
- PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice.
- J Exp Med. 1999 Oct 18;190(8):1059-68. Unique Identifier : AIDSLINE MED/99454910
- Jacobs H; Krimpenfort P; Haks M; Allen J; Blom B; Demolliere C; Kruisbeek A; Spits H; Berns A; Basel Institute for Immunology, CH-4005 Basel, Switzerland.; Jacobs@BIL.CH
- The majority of lymphomas induced in Rag-deficient mice by Moloney murine leukemia virus (MoMuLV) infection express the CD4 and/or CD8 markers, indicating that proviral insertions cause activation of genes affecting the development from CD4(-)8(-) pro-T cells into CD4(+)8(+) pre-T cells. Similar to MoMuLV wild-type tu
- The activated type 1-polarized CD8(+) T cell population isolated from an effector site contains cells with flexible cytokine profiles.
- J Exp Med. 1999 Oct 18;190(8):1081-92. Unique Identifier : AIDSLINE MED/99454912
- Doyle AG; Buttigieg K; Groves P; Johnson BJ; Kelso A; Queensland Institute of Medical Research, Brisbane, Queensland; 4029, Australia.
- The capacity of activated T cells to alter their cytokine expression profiles after migration into an effector site has not previously been defined. We addressed this issue by paired daughter analysis of a type 1-polarized CD8(+) effector T cell population freshly isolated from lung parenchyma of influenza virus-infec
- Lamivudine in the treatment of hepatitis B virus reactivation during cytotoxic chemotherapy.
- J Med Virol. 1999 Nov;59(3):263-9. Unique Identifier : AIDSLINE MED/99432067
- Yeo W; Steinberg JL; Tam JS; Chan PK; Leung NW; Lam KC; Mok TS; Johnson PJ; Department of Clinical Oncology, Chinese University of Hong Kong,; Sir YK Pao Cancer Centre, Prince of Wales Hospital, Shatin, NT,; Hong Kong.
- Hepatitis B virus (HBV) reactivation has been described in cancer patients who received cytotoxic/immunosuppressive therapy and may result in liver damage of varying degrees of severity. There is no known effective treatment. Lamivudine , a nucleoside
- Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B.
- J Med Virol. 1999 Nov;59(3):270-6. Unique Identifier : AIDSLINE MED/99432068
- Ogata N; Fujii K; Takigawa S; Nomoto M; Ichida T; Asakura H; Third Department of Internal Medicine, Niigata University School; of Medicine, Niigata, Japan.
- Lamivudine is effective in suppressing replication of hepatitis B virus (HBV). However, the emergence of HBV variants resistant to lamivudine is a concern. Lamivudine resistance has been attributed mainly to a substitution of isoleucine or valine for
- Risk and clearance of GB virus C/hepatitis G virus infection in homosexual men: A longitudinal study.
- J Med Virol. 1999 Nov;59(3):303-6. Unique Identifier : AIDSLINE MED/99432073
- Stark K; Doering CD; Bienzle U; Pauli G; Hamouda O; Engel AM; Schreier E; Institute of Tropical Medicine, Charite, Humboldt University,; Berlin, Germany. klaus.stark@charite.de
- The risk and clearance of GB virus type C (GBV-C)/hepatitis G virus (HGV) infection was investigated in a cohort of homosexual men (n=180; median follow-up time, 7 years). The interaction between GBV-C/HGV RNA and antibodies against the E2 region of the virus, and the clinical impact of chronic GBV-C/HGV infection wer
- Response of asymptomatic cytomegalovirus viraemia to oral ganciclovir 3 g/day or 6 g/day in HIV-infected patients.
- J Med Virol. 1999 Nov;59(3):323-8. Unique Identifier : AIDSLINE MED/99432077
- Grzywacz M; Deayton JR; Bowen EF; Wilson P; Emery VC; Johnson MA; Griffiths PD; Department of Virology, Royal Free and University College Medical; School of University College London, London, England.
- Reactivation of cytomegalovirus ( CMV ) following immunosuppression may result in the development of CMV disease and is associated with an increased risk of death. CMV viraemia detected by the polymerase chain reaction (PCR) pr
- Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures.
- J Med Virol. 1999 Nov;59(3):335-40. Unique Identifier : AIDSLINE MED/99432079
- Chaturvedi UC; Elbishbishi EA; Agarwal R; Raghupathy R; Nagar R; Tandon R; Pacsa AS; Younis OI; Azizieh F; Department of Microbiology, Faculty of Medicine, Kuwait; University, Safat, Kuwait. chaturvedihsc.kuniv.edu.kw
- The study was undertaken to elucidate the sequence of appearance of T helper (Th)1- and Th2-type cytokines in human peripheral blood leucocyte cultures infected in vitro with dengue type 2 virus. Commercial sandwich enzyme-linked immunosorbent assay kits were used to assay the levels of tumour necrosis factor-alpha (T
- Expression and antigenicity of human herpesvirus 8 encoded ORF59 protein in AIDS-associated Kaposi's sarcoma.
- J Med Virol. 1999 Nov;59(3):346-55. Unique Identifier : AIDSLINE MED/99432081
- Katano H; Sata T; Suda T; Nakamura T; Tachikawa N; Nishizumi H; Sakurada S; Hayashi Y; Koike M; Iwamoto A; Kurata T; Mori S; Department of Pathology, Institute of Medical Science, The; University of Tokyo, Tokyo, Japan. katano@nih.go.jp
- Human herpesvirus 8 (HHV-8, Kaposi s sarcoma-associated herpesvirus, KSHV) is a new herpes virus isolated from patients with AIDS-associated Kaposi s sarcoma (AIDS-KS). The ORF59 protein of HHV-8 has recently been shown to encode a processivity factor (PF-8) for HHV-8-encoded DNA polymerase. By immunoscreening a cDNA
- HIV-1 in semen: determination of proviral and viral titres compared to blood, and quantification of semen leukocyte populations.
- J Med Virol. 1999 Nov;59(3):356-63. Unique Identifier : AIDSLINE MED/99432082
- Ball JK; Curran R; Irving WL; Dearden AA; Division of Microbiology and Infectious Diseases, University of; Nottingham, Queen's Medical Centre, Nottingham, UK.; jonathan.ball@nottingham.ac.uk
- This study was carried out to determine the relationship between proviral DNA and viral RNA titres in semen compared with blood. In addition, the association between semen leukocyte counts with detection frequency and absolute levels of human immunodeficiency virus type 1 (HIV-1) nucleic acids was also assessed. Paire
- Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy.
- J Med Virol. 1999 Nov;59(3):364-8. Unique Identifier : AIDSLINE MED/99432083
- Clarke JR; Braganza R; Mirza A; Stainsby C; Ait-Khaled M; Wright A; Lyall H; Parker D; McClure MO; Weber JN; Taylor GP; Department of Genitourinary Medicine and Communicable Diseases,; Division of Medicine, Imperial College School of Medicine, St.; Mary's Hospital, London, England. j.r.clarke@ic.ac.uk
- The prevention of mother to child transmission of HIV-1 by zidovudine monotherapy is well known, but increasingly combination anti-retroviral therapy is prescribed during pregnancy. In this prospective study, 19 pregnant women with human immunodeficiency virus-1 (HIV-1) infection who elected to take anti-retroviral th
- Simultaneous treatment of cytomegalovirus and varicella zoster infections in a renal transplant recipient with ganciclovir: use of viral load to monitor response to treatment.
- Unique Identifier : AIDSLINE MED/99432089
- Aitken C; Hawrami K; Miller C; Barrett Muir W; Yaqoob M; Breuer J; Department of Medical Microbiology and Virology, St. Barts and; the Royal London Hospitals, London, United Kingdom.
- Disseminated zoster occurring simultaneously with cytomegalovirus ( CMV ) disease in a renal transplant recipient is potentially life threatening. We describe the use of intravenous ganciclovir to treat both infections. The eff
- Reduced concentrations of HIV-RNA and TNF-alpha coexist in CSF of AIDS patients with progressive multifocal leukoencephalopathy.
- J Neurol Neurosurg Psychiatry. 1999 Sep;67(3):369-73. Unique Identifier : AIDSLINE MED/99380434
- Monno L; Zimatore GB; Di Stefano M; Appice A; Livrea P; Angarano G; Clinic of Infectious Diseases, University of Bari, Bari, Italy.
- OBJECTIVES: To confirm reduced human immunodeficiency virus type-1 (HIV-1) burden in the CSF of patients with progressive multifocal leukoencephalopathy (PML) and to verify whether this viral load coincides with the absence of inflammatory changes in the CSF. METHODS: Paired CSF and plasma samples from 17 patients wit
- MRI appearances of the facial nerve in an HIV infected patient with acute facial nerve palsy.
- J Neurol Neurosurg Psychiatry. 1999 Sep;67(3):407-8. Unique Identifier : AIDSLINE MED/99380443
- Miszkiel KA; Miller RF; MRI Unit, Imaging Department at UCL Hospitals (NHS) Trust,; London, UK.
- Zidovudine-induced experimental myopathy: dual mechanism of mitochondrial damage.
- J Neurol Sci. 1999 Jul 1;166(2):131-40. Unique Identifier : AIDSLINE MED/99402092
- Masini A; Scotti C; Calligaro A; Cazzalini O; Stivala LA; Bianchi L; Giovannini F; Ceccarelli D; Muscatello U; Tomasi A; Vannini V; Dipartimento di Scienze Biomediche, Universita di Modena, Italy.
- Myopathy often complicates Zidovudine ( AZT ) treatment in patients with acquired immunodeficiency syndrome (AIDS). The pathogenesis of the myopathy is controversial, since clinical phenomena intrinsic to AIDS may interfere per se with the onset of the
- Age-dependent paraparesis in WKA rats: evaluation of MHC k-haplotype and HTLV-1 infection.
- J Neurol Sci. 1999 Aug 1;167(1):16-21. Unique Identifier : AIDSLINE MED/99432103
- Sun B; Fang J; Yagami K; Kushida S; Tanaka M; Uchida K; Miwa M; Department of Biochemistry and Molecular Oncology, Institute of; Basic Medical Sciences and Center for Tsukuba Advanced Research; Alliance, University of Tsukuba, Tsukuba, Japan.
- Human T-cell leukemia virus type 1 (HTLV-1) infection is shown to be closely associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the occurrence of HAM/TSP was reported to be associated with MHC class II, the mechanism is still unclear. The WKA(RT1k) strain of rats was reported
- Motor and somatosensory evoked potential findings in HTLV-I associated myelopathy.
- J Neurol Sci. 1999 Aug 15;167(2):102-6. Unique Identifier : AIDSLINE MED/99453306
- Suga R; Tobimatsu S; Kira J; Kato M; Department of Clinical Neurophysiology, Neurological Institute,; Faculty of Medicine, Kyushu University, 3-1-1 Maidashi,; Higashi-ku, Fukuoka, Japan. suga@neurophy.med.kyushu-u.ac.jp
- The central motor and sensory conduction times were measured using the motor and somatosensory evoked potentials in 21 patients with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) to evaluate the functions of the corticospinal tract and posterior column. The control subjects were closely matched f
- Early entry and widespread cellular involvement of HIV-1 DNA in brains of HIV-1 positive asymptomatic individuals.
- J Neuropathol Exp Neurol. 1999 Nov;58(11):1156-62. Unique Identifier : AIDSLINE MED/20023314
- An SF; Groves M; Gray F; Scaravilli F; Department of Neuropathology, Institute of Neurology, University; College London, United Kingdom.
- There is overwhelming evidence that invasion of the central nervous system (CNS) by HIV-1 takes place at an early stage of the infection. It has been demonstrated that HIV-1 DNA is present in brains of asymptomatic individuals. Evidence of immune activation and increased expression of cytokines suggested that neuropat
- Primitive reflexes in a case-control study of patients with advanced human immunodeficiency virus type 1.
- J Neurol. 1999 Jul;246(7):540-3. Unique Identifier : AIDSLINE MED/99390994
- Tremont-Lukats IW; Teixeira GM; Hernandez DE; Department of Neurology, University of Wisconsin Hospital and; Clinics, Madison 53792-5132, USA. itremont@facstaff.wisc.edu
- This study estimated the frequency of nine primitive reflexes (PR) and assessed their possible clinical value in a group of patients with acquired immunodeficiency syndrome. We studied 78 patients with human inmunodeficiency type 1 (HIV-1) infection in WHO clinical stage 3 or 4 and 81 matched seronegative controls. Al
- Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro.
- J Neurooncol. 1999 Jun;43(2):109-14. Unique Identifier : AIDSLINE MED/20001289
- Moreira AL; Friedlander DR; Shif B; Kaplan G; Zagzag D; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, NY, USA.
- Angiogenesis is a crucial process in inflammatory reactions as well as in tumor implantation and growth. Tumors with high rates of invasion and recurrence such as gliomas, are specially dependent on neovascularization. This suggests that inhibition of angiogenesis might reduce the growth of these tumors. Thalidomide h
- Soluble factors, including TNF alpha, secreted by human T cells are both cytotoxic and cytostatic for medulloblastoma cells.
- J Neurooncol. 1999 Jun;43(2):115-26. Unique Identifier : AIDSLINE MED/20001290
- Dufay N; Reboul A; Touraine-Moulin F; Belin MF; Giraudon P; INSERM U433, Hopital Neurologique et Neurochirurgical, BP Lyon; Montchat, France.
- We studied the effect of the treatment of a medulloblastoma cell line by human T cells derived soluble factors. Medulloblastoma is one of the more common aggressive solid neoplasms in children for which there is no adequate therapy. Cell lines established from such tumours may be helpful to test the effect of various
- Structure-based drug design approaches for predicting binding affinities of HIV1 protease inhibitors.
- J Enzyme Inhib. 1998;14(1):1-14. Unique Identifier : AIDSLINE MED/99449066
- Reddy MR; Erion MD; Metabasis Therapeutics, Inc., San Diego, CA 92121, USA.
- Computational assessment of the binding affinity of enzyme inhibitors prior to synthesis is an important component of computer-assisted drug design (CADD) paradigms. The free energy perturbation (FEP) methodology is the most accurate means of estimating relative binding affinities between two inhibitors. However, due
- Risk factors for early hospital readmission in patients with AIDS and pneumonia.
- J Gen Intern Med. 1999 Sep;14(9):531-6. Unique Identifier : AIDSLINE MED/99421866
- Grant RW; Charlebois ED; Wachter RM; Department of Medicine, Massachusetts General Hospital, Boston,; MA, USA.
- OBJECTIVE: To determine risk factors for early readmission to the hospital in patients with AIDS and pneumonia. DESIGN: Case-control analysis. SETTING: A municipal teaching hospital serving an indigent population. PATIENTS: Case patients were all AIDS patients hospitalized with Pneumocystis carinii pneumonia or bacter
- Accidental occupational exposure of intravenous nurses to human immunodeficiency virus. Anticipating the consequences.
- J Intraven Nurs. 1998 Jul-Aug;21(4):215-20. Unique Identifier : AIDSLINE MED/99083769
- Meisenhelder JB; Graduate Nursing Program, Massachusetts General Hospital, Boston,; USA.
- This descriptive study randomly surveyed all 302 Massachusetts members of the Intravenous Nurses Society in 1991 regarding their perceptions of nine possible consequences of human immunodeficiency virus (HIV) infection caused by accidental occupational exposure. Areas of highest concern were financial: adequacy of wor
- Miami's Target Cities Project: past and present lessons.
- J Psychoactive Drugs. 1999 Jul-Sep;31(3):211-7. Unique Identifier : AIDSLINE MED/20001533
- Rivers JE; Komaroff E; Mendoza JL; University of Miami Comprehensive Drug Research Center, Florida; 33136, USA.
- HIV needle risk behaviors and drug use: a comparison of crack-smoking and nonsmoking injection drug users in Ohio.
- J Psychoactive Drugs. 1999 Jul-Sep;31(3):291-7. Unique Identifier : AIDSLINE MED/20001543
- Carlson RG; Falck RS; Wang J; Siegal HA; Rahman A; Department of Community Health, School of Medicine, Wright State; University, Dayton, Ohio 45435, USA. rcarlson@wright.edu
- This study compares the drug use and needle risk behaviors among 733 crack-smoking injection drug users (IDUs) and 518 nonsmoking IDUs. Participants were recruited in Dayton and Columbus, Ohio, for the Cooperative Agreement for AIDS Community-Based Outreach/Intervention Research Program from 1992 to 1996. Crack-smokin
- Viral infections in interferon-gamma receptor deficiency [see comments]
- J Pediatr. 1999 Nov;135(5):640-3. Unique Identifier : AIDSLINE MED/20015046
- Dorman SE; Uzel G; Roesler J; Bradley JS; Bastian J; Billman G; King S; Filie A; Schermerhorn J; Holland SM; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, Department of Pathology, National Institutes; of Health, Bethesda, Maryland 20892, USA.
- Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The
- The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type I--a meta-analysis of 15 prospective cohort studies.
- J Pediatr. 1999 Nov;135(5):649. Unique Identifier : AIDSLINE MED/20039228
- Brockleburst P; Radcliffe Infirmary, Oxford, UK.
- High viral load and mild liver injury in children with hemophilia compared with other children with chronic hepatitis C virus infection.
- J Pediatr Gastroenterol Nutr. 1999 Oct;29(4):418-23. Unique Identifier : AIDSLINE MED/99440953
- Zellos A; Thomas DL; Mocilnikar C; Perlman EJ; Boitnott JK; Casella JF; Schwarz KB; Department of Pediatrics, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.
- BACKGROUND: In adults with hepatitis C virus (HCV) infection, the severity of liver disease may be influenced by the mode of transmission. The purpose of this study was to evaluate whether the mode of transmission affects liver injury and viral load in children with chronic HCV infection, independent of duration of in
- Reproductive choice in individuals HIV-1 infected in south eastern Italy.
- J Perinat Med. 1999;27(3):173-7. Unique Identifier : AIDSLINE MED/99432795
- Greco P; Vimercati A; Fiore JR; Saracino A; Buccoliero G; Loverro G; Angarano G; Pastore G; Selvaggi L; Department of Obstetrics and Gynecology, University of Bari,; Italy. p.greco@gynecology2.uniba.it
- OBJECTIVE: To evaluate the impact of counseling on reproductive choices in seropositive women in South-Eastern Italy . SETTING: University Hospital, Apulia region, South-Eastern Italy, tertiary referral center for high risk obstetrics and infectious diseases. METHODS: Between March 1
- Arbitrarily primed-polymerase chain reaction for identification and epidemiologic subtyping of oral isolates of Fusobacterium nucleatum.
- J Periodontol. 1999 Oct;70(10):1202-8. Unique Identifier : AIDSLINE MED/20001642
- Avila-Campos MJ; Sacchi CT; Whitney AM; Steigerwalt AG; Mayer LW; Department of Microbiology, University of Sao Paulo, SP, Brazil.
- BACKGROUND: Fusobacterium nucleatum is the most frequently isolated bacterium in periodontal disease and plays an important role in serious infections in other parts of the body. Arbitrarily primed-polymerase chain reaction (AP-PCR) was used to construct primers for specific identification and subtyping of F. nucleatu
- Stress accelerates the slide from HIV to AIDS [news]
- J Psychosoc Nurs Ment Health Serv. 1999 Jul;37(7):7. Unique Identifier : AIDSLINE MED/99341196
- Human immunodeficiency virus associated spondyloarthropathy: lessons from the Third World [editorial; comment]
- J Rheumatol. 1999 Oct;26(10):2071-3. Unique Identifier : AIDSLINE MED/99456395
- Cuellar ML; Espinoza LR
- Is HIV the culprit? Spondyloarthropathy in the Third World [editorial; comment]
- J Rheumatol. 1999 Oct;26(10):2074-5. Unique Identifier : AIDSLINE MED/99456396
- Njobvu PD; McGill PE
- Antenatal HIV testing: a dilemma.
- J R Soc Health. 1999 Sep;119(3):144. Unique Identifier : AIDSLINE MED/99446617
- Dickerson JW
- Synthesis and antiviral activity of ethidium-arginine conjugates directed against the TAR RNA of HIV-1.
- J Med Chem. 1999 Oct 7;42(20):4042-53. Unique Identifier : AIDSLINE MED/99445667
- Peytou V; Condom R; Patino N; Guedj R; Aubertin AM; Gelus N; Bailly C; Terreux R; Cabrol-Bass D; Laboratoire de Chimie Bioorganique, CNRS ESA 6001, Universite de; Nice Sophia-Antipolis, F-06108 Nice Cedex 2, France.
- The regulatory protein Tat is essential for viral gene expression and replication of the human immunodeficiency virus type 1 (HIV-1). Tat transactivates the HIV-1 long terminal repeat (LTR) via its binding to the transactivation responsive element (TAR) and increases the viral transcription. Studies have shown that th
- Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of a symmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains.
- J Med Chem. 1999 Oct 7;42(20):4054-61. Unique Identifier : AIDSLINE MED/99445668
- Hulten J; Andersson HO; Schaal W; Danielson HU; Classon B; Kvarnstrom I; Karlen A; Unge T; Samuelsson B; Hallberg A; Department of Organic Pharmaceutical Chemistry, Uppsala; Biomedical Centre, Uppsala University, Box 574, SE-751 23; Uppsala, Sweden.
- Symmetric cyclic sulfamides, substituted in the P2/P2 position with functional groups foreseen to bind preferentially to the S2/S2 subsites of HIV-1 protease, have been prepared. Despite efforts to promote a symmetric binding, the sulfamides seemed prone to bind nonsymmetrically, as deduced from X-ray crystal struct
- A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6.
- J Med Chem. 1999 Oct 7;42(20):4062-70. Unique Identifier : AIDSLINE MED/99445669
- de Groot MJ; Ackland MJ; Horne VA; Alex AA; Jones BC; Department of Molecular Informatics, Pfizer Central Research,; Sandwich, Kent CT13 9NJ, United Kingdom.
- A combined protein and pharmacophore model for cytochrome P450 2D6 (CYP2D6) has been extended with a second pharmacophore in order to explain CYP2D6 catalyzed N-dealkylation reactions. A group of 14 experimentally verified N-dealkylation reactions form the basis of this second pharmacophore. The combined model can now
- Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.
- J Med Chem. 1999 Oct 7;42(20):4122-8. Unique Identifier : AIDSLINE MED/99445675
- Siddiqui AQ; McGuigan C; Ballatore C; Zuccotto F; Gilbert IH; De Clercq E; Balzarini J; Welsh School of Pharmacy, Cardiff University, King Edward VII; Avenue, Cardiff CF1 3XF, U.K.
- A series of new substituted-aryl phosphoramidate derivatives of the anti-HIV drug d4T were synthesized as membrane-soluble nucleotide prodrugs, to extend and quantify the SAR observed for an earlier series of related derivatives. All of the compounds
- Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.
- J Med Chem. 1999 Oct 7;42(20):4140-9. Unique Identifier : AIDSLINE MED/99445677
- Genin MJ; Poel TJ; May PD; Kopta LA; Yagi Y; Olmsted RA; Friis JM; Voorman RL; Adams WJ; Thomas RC; Romero DL; Medicinal Chemistry Research, Infectious Diseases Research,; Discovery Technologies, Pharmacia & Upjohn, Inc., Kalamazoo,; Michigan 49001, USA.
- Development of resistance to currently approved HIV therapies has continued to fuel research efforts to improve the metabolic stability and spectrum of activity of the (alkylamino)piperidine-containing bis(heteroaryl)piperazine (AAP-BHAP) class of non-nucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis
- Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
- J Med Chem. 1999 Oct 7;42(20):4150-60. Unique Identifier : AIDSLINE MED/99445678
- Hogberg M; Sahlberg C; Engelhardt P; Noreen R; Kangasmetsa J; Johansson NG; Oberg B; Vrang L; Zhang H; Sahlberg BL; Unge T; Lovgren S; Fridborg K; Backbro K; Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden.
- The further development of allosteric HIV-1 RT inhibitors in the urea analogue series of PETT (phenylethylthiazolylthiourea) derivatives is described here. The series includes derivatives with an ethyl linker (1-5) and racemic (6-16) and enantiomeric (17-20) cis-cyclopropane compounds. The antiviral activity was deter
- Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
- J Med Chem. 1999 Oct 21;42(21):4462-70. Unique Identifier : AIDSLINE MED/20013279
- Campiani G; Morelli E; Fabbrini M; Nacci V; Greco G; Novellino E; Ramunno A; Maga G; Spadari S; Caliendo G; Bergamini A; Faggioli E; Uccella I; Bolacchi F; Marini S; Coletta M; Nacca A; Caccia S; Dipartimento di Scienze Farmaceutiche, Facolta' di Farmacia,; Universita' degli Studi di Salerno, via Ponte don Melillo, 84084; Fisciano (SA), Italy. campiani@unisa.it
- Pyrrolobenzoxazepinone (PBO) derivatives represent a new class of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTs) whose prototype is (+/-)-6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)- one (6). Docking studies based on the three-dimensional structure of
- Penicilliosis marneffei--West meets East [editorial]
- J Med Microbiol. 1999 Nov;48(11):973-5. Unique Identifier : AIDSLINE MED/20004297
- Wong SS; Siau H; Yuen KY
- Comparison of lymphocyte subpopulations in the peripheral blood of patients with infectious mononucleosis and human immunodeficiency virus infection: a preliminary report.
- J Clin Lab Immunol. 1998;50(2):63-9. Unique Identifier : AIDSLINE MED/99399645
- Zidovec S; Culig Z; Begovac J; Jeren T; University Hospital for Infectious Diseases Dr. Fran Mihaljevic,; Zagreb, Croatia.
- The aim of this study was to analyse the lymphocyte subpopulations in the peripheral blood of HIV-1-infected adults to compare them with four patients with acute EBV infection. Lymphocyte subsets in 15 healthy controls, 40 HIV-1-infected adults and 4 EBV-infected patients with infectious mononucleosis were analysed by
- Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nucleic acid substrate.
- J Mol Biol. 1999 Sep 17;292(2):333-44. Unique Identifier : AIDSLINE MED/99425315
- Wohrl BM; Krebs R; Goody RS; Restle T; Abteilung Physikalische Biochemie, Max-Planck-Institut fur; Molekulare Physiologie, Otto-Hahn-Strasse 11, Dortmund, 44227,; Germany. birgit.woehrl@mpi-dortmund.mpg.de
- The kinetic mechanism of nucleic acid substrate binding and nucleotide incorporation by human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) was analysed using synthetic DNA/DNA and DNA/RNA primer/templates (p/t) without predicted secondary structures in the single-stranded region. Determination of the
- How NF-kappaB can be attracted by its cognate DNA.
- J Mol Biol. 1999 Oct 15;293(1):139-50. Unique Identifier : AIDSLINE MED/99443907
- Tisne C; Delepierre M; Hartmann B; Institut Pasteur, CNRS URA 1129, 28 rue du Docteur Roux, Paris,; 75015, France. tisne@pasteur.fr
- NF-kappaB is involved in the transcriptional regulation of a large number of genes, in particular those of human immunodeficiency virus (HIV). Recently, we used NMR spectroscopy and molecular modelling to study the solution structure of a native duplex related to the HIV-1 kappaB site, together with a mutated duplex f
- Tackling Tat.
- J Mol Biol. 1999 Oct 22;293(2):235-54. Unique Identifier : AIDSLINE MED/20020727
- Karn J; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2; 2QH, UK. karn@mrc-lmb.cam.ac.uk
- Activation of cellular genes typically involves control of transcription initiation by DNA-binding regulatory proteins. The human immunodeficiency virus transactivator protein, Tat, provides the first example of the regulation of viral gene expression through control of elongation by RNA polymerase II. In the absence
- KS enters Y2K still riddled with many questions [news]
- J Natl Cancer Inst. 1999 Oct 6;91(19):1612-4. Unique Identifier : AIDSLINE MED/99442431
- Miller M
- Human herpesvirus 8 latent-state gene expression and apoptosis in Kaposi's sarcoma lesions [editorial; comment]
- J Natl Cancer Inst. 1999 Oct 20;91(20):1705-7. Unique Identifier : AIDSLINE MED/20013282
- Hayward GS
- Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.
- J Natl Cancer Inst. 1999 Oct 20;91(20):1725-33. Unique Identifier : AIDSLINE MED/20013292
- Sturzl M; Hohenadl C; Zietz C; Castanos-Velez E; Wunderlich A; Ascherl G; Biberfeld P; Monini P; Browning PJ; Ensoli B; Institute of Molecular Virology, GSF-National Research Center for; Environment and Health, Neuherberg, Germany. Stuerzl@gsf.de
- BACKGROUND: Human herpesvirus 8 (HHV8) infection is associated with all forms of Kaposi s sarcoma (KS). The HHV8 genome locus ORFK13-72-73 (ORF = open reading frame) encodes proteins that may be important in HHV8-mediated pathogenesis, i.e., the latency-associated nuclear antigen (encoded by ORF73), viral-cyc-D (v-cyc
- Risk of transfusion-associated transmission of human herpesvirus 8.
- J Natl Cancer Inst. 1999 Oct 20;91(20):1773-5. Unique Identifier : AIDSLINE MED/20013299
- Engels EA; Eastman H; Ablashi DV; Wilks RJ; Braham J; Manns A; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Bethesda, MD, USA.; engelse@exchange.nih.gov
- Frequency and factors associated with cardiomyopathy in patients with human immunodeficiency virus infection in an inner-city hospital.
- J Natl Med Assoc. 1999 Sep;91(9):502-4. Unique Identifier : AIDSLINE MED/99446266
- Roy VP; Prabhakar S; Pulvirenti J; Mathew J; Division of Adult Cardiology, Cook County Hospital, Chicago, IL,; USA.
- The frequency and factors associated with cardiomyopathy were studied among inner-city hospital patients with human immunodeficiency virus (HIV) infection. Of 84 patients with HIV infection, 20 (24%) had cardiomyopathy. Fourteen (70%) of the patients with cardiomyopathy did not have clinical evidence of congestive hea
- An Mpsi-containing heterologous RNA, but not env mRNA, is efficiently packaged into avian retroviral particles.
- J Virol. 1999 Nov;73(11):8926-33. Unique Identifier : AIDSLINE MED/99445796
- Banks JD; Kealoha BO; Linial ML; Division of Basic Sciences, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98109, USA.
- Retroviruses preferentially package full-length genomic RNA over spliced viral messages. For most retroviruses, this preference is likely due to the absence of all or part of the packaging signal on subgenomic RNAs. In avian leukosis-sarcoma virus, however, we have shown that the minimal packaging signal, MPsi, is loc
- A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor.
- J Virol. 1999 Nov;73(11):8966-74. Unique Identifier : AIDSLINE MED/99445801
- Trkola A; Matthews J; Gordon C; Ketas T; Moore JP; The Aaron Diamond AIDS Research Center, New York University; School of Medicine, New York, New York, USA.
- We describe here a cell line-based assay for the evaluation of human immunodeficiency virus type 1 (HIV-1) neutralization. The assay is based on CEM.NKR cells, transfected to express the HIV-1 coreceptor CCR5 to supplement the endogenous expression of CD4 and the CXCR4 coreceptor. The resulting CEM.NKR-CCR5 cells effi
- Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis.
- J Virol. 1999 Nov;73(11):9011-20. Unique Identifier : AIDSLINE MED/99445806
- Brown HE; Chen H; Engelman A; Department of Cancer Immunology, Dana-Farber Cancer Institute; Boston, Massachusetts 02115, USA.
- Sequences at the ends of linear retroviral cDNA important for integration define the viral DNA attachment (att) site. Whereas determinants of human immunodeficiency virus type 1 (HIV-1) integrase important for replication in T lymphocytes have been extensively characterized, regions of the att site important for viral
- Inhibition of replication of reactivated human immunodeficiency virus type 1 (HIV-1) in latently infected U1 cells transduced with an HIV-1 long terminal repeat-driven PKR cDNA construct.
- J Virol. 1999 Nov;73(11):9021-8. Unique Identifier : AIDSLINE MED/99445807
- Muto NF; Martinand-Mari C; Adelson ME; Suhadolnik RJ; Fels Institute for Cancer Research, Temple University School of; Medicine, Philadelphia, Pennsylvania 19140, USA.
- Treatment of human immunodeficiency virus type 1 (HIV-1)-infected individuals with highly active antiretroviral therapy has effectively decreased viral load to undetectable levels. However, efforts to eliminate HIV-1 from these individuals have been unsuccessful, due to the presence of stable, latent viral reservoirs
- Human immunodeficiency virus type 1-induced hematopoietic inhibition is independent of productive infection of progenitor cells in vivo.
- J Virol. 1999 Nov;73(11):9089-97. Unique Identifier : AIDSLINE MED/99445814
- Koka PS; Jamieson BD; Brooks DG; Zack JA; Division of Hematology, Department of Medicine, Jonsson; Comprehensive Cancer Center, UCLA AIDS Institute, UCLA School of; Medicine, Los Angeles, California 90095, USA.
- Human immunodeficiency virus (HIV)-infected individuals exhibit a variety of hematopoietic dysfunctions. The SCID-hu mouse (severe combined immunodeficient mouse transplanted with human fetal thymus and liver tissues) can be used to model the loss of human hematopoietic precursor cell function following HIV infection
- Evaluation of novel human immunodeficiency virus type 1 Gag DNA vaccines for protein expression in mammalian cells and induction of immune responses.
- J Virol. 1999 Nov;73(11):9145-52. Unique Identifier : AIDSLINE MED/99445820
- Qiu JT; Song R; Dettenhofer M; Tian C; August T; Felber BK; Pavlakis GN; Yu XF; Department of Molecular Microbiology, The Johns Hopkins School of; Hygiene and Public Health, Baltimore, Maryland 21205, USA.
- Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) are an important parameter of host defenses that limit viral replication after infection. Induction of effective CTL against conserved viral proteins such as Gag may be essential to the development of a safe and effective HIV type 1 (HIV-1) vacc
- Longitudinal phenotypic analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes: correlation with disease progression.
- J Virol. 1999 Nov;73(11):9153-60. Unique Identifier : AIDSLINE MED/99445821
- Ogg GS; Kostense S; Klein MR; Jurriaans S; Hamann D; McMichael AJ; Miedema F; MRC Human Immunology Unit, Institute of Molecular Medicine,; Oxford OX3 9DS, United Kingdom. gogg@worf.molbiol.ox.ac.uk
- Few studies have examined longitudinal changes in human immunodeficiency virus type 1 (HIV)-specific cytotoxic T lymphocytes (CTL). To more closely define the natural history of HIV-specific CTL, we used HLA-peptide tetrameric complexes to study the longitudinal CD8(+) T-cell response evolution in 16 A*0201-positive u
- Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo.
- Unique Identifier : AIDSLINE MED/99445822
- Brawand P; Cerottini JC; MacDonald HR; Ludwig Institute for Cancer Research, Lausanne Branch, 1066
- The CD8(+)-T-cell response to Moloney murine leukemia virus (M-MuLV)-associated antigens in C57BL/6 mice is directed against an immunodominant gag-encoded epitope (CCLCLTVFL) presented in the context of H-2D(b) and is restricted primarily to cytotoxic T lymphocytes (CTL) expressing the Valpha3.2 and Vbeta5.2 gene segm
- The nucleocapsid domain is responsible for the ability of spleen necrosis virus (SNV) Gag polyprotein to package both SNV and murine leukemia virus RNA.
- J Virol. 1999 Nov;73(11):9170-7. Unique Identifier : AIDSLINE MED/99445823
- Certo JL; Kabdulov TO; Paulson ML; Anderson JA; Hu WS; Mary Babb Randolph Cancer Center, West Virginia University,; Morgantown, West Virginia 26506, USA.
- Murine leukemia virus (MLV)-based vector RNA can be packaged and propagated by the proteins of spleen necrosis virus (SNV). We recently demonstrated that MLV proteins cannot support the replication of an SNV-based vector; RNA analysis revealed that MLV proteins cannot efficiently package SNV-based vector RNA. The doma
- Evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 Epstein-Barr virus.
- J Virol. 1999 Nov;73(11):9206-12. Unique Identifier : AIDSLINE GENBANK/AF183140
- Cho YG; Gordadze AV; Ling PD; Wang F; Department of Medicine, Brigham & Women's Hospital, Harvard; Medical School, Boston, Massachusetts 02115, USA.
- Rhesus monkeys and other nonhuman Old World primates are naturally infected with lymphocryptoviruses (LCV) that are closely related to Epstein-Barr virus (EBV). A rhesus LCV isolate (208-95) was derived from a B-cell lymphoma in a simian immunodeficiency virus-infected rhesus macaque. The EBNA-2 homologues from 208-95
- Genetic stability of foamy viruses: long-term study in an African green monkey population.
- J Virol. 1999 Nov;73(11):9256-65. Unique Identifier : AIDSLINE +
- Schweizer M; Schleer H; Pietrek M; Liegibel J; Falcone V; Neumann-Haefelin D; Abteilung Virologie, Institut fur Medizinische Mikrobiologie und; Hygiene, University of Freiburg, Freiburg, Germany.; mschweiz@ukl.uni-freiburg.de
- The genetic variability of the envelope surface domain (SU) of simian foamy virus (FV) of African green monkeys was studied. To assess the interindividual diversity of FV, isolates were obtained from 19 animals living together in a monkey house. The monkeys had been imported from Kenya
- Incorporation of wild-type and C-terminally truncated human epidermal growth factor receptor into human immunodeficiency virus-like particles: insight into the processes governing glycoprotein incorporation into retroviral particles.
- J Virol. 1999 Nov;73(11):9294-302. Unique Identifier : AIDSLINE MED/99445837
- Henriksson P; Pfeiffer T; Zentgraf H; Alke A; Bosch V; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, D-69120 Heidelberg, Germany.
- Previous results have indicated that incorporation of surface glycoprotein into retroviral particles is not a specific process and that many heterologous viral and cellular glycoproteins can be incorporated as long as they do not have long cytoplasmic C-terminal regions which were presumed to be sterically inhibitory.
- The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro.
- J Virol. 1999 Nov;73(11):9337-47. Unique Identifier : AIDSLINE MED/99445841
- Creson JR; Lin AA; Li Q; Broad DF; Roberts MR; Anderson SJ; Cell Genesys, Inc., Foster City, California 94404, USA.
- We have investigated the ability of anti-CD28 antibody costimulation to induce resistance to macrophage (M)-tropic strains of human immunodeficiency virus type 1 (HIV-1) in vitro. Our results confirm the observations of Levine et al. (15) that stimulation of CD4 T cells with anti-CD3/anti-CD28 antibodies coimmobilized
- Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells.
- J Virol. 1999 Nov;73(11):9348-61. Unique Identifier : AIDSLINE MED/99445842