Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa.

AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1307-12. Unique Identifier : AIDSLINE GENBANK/AJ246945
Parreira R; Esteves A; Santos C; Piedade J; Venenno T; Canas-Ferreira WF; Unidade de Virologia/Unidade de Parasitologia e Microbiologia; Medicas, Instituto de Higiene e Medicina Tropical, Universidade; Nova de Lisboa, Portugal. Ricardo@ihmt.unl.pt

Abstract: The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositive individuals from Bissau (Guinea-Bissau). The estimated values of genetic divergence between individuals were higher than those calculated from sequence information collected in a single individual. We have also found that the sequences surrounding the V3 loop contribute significantly to the overall genetic diversity of the C2V3 region of HIV-2 gp105, while the V3 loop itself seems to be rather conserved. Phylogenetic analysis demonstrated that all the individuals enrolled in this study were infected with HIV-2 subtype A viruses.

Keywords: JOURNAL ARTICLE Adolescence Adult Amino Acid Sequence DNA, Viral/BLOOD Female Guinea-Bissau/EPIDEMIOLOGY Human HIV Envelope Protein gp120/*GENETICS HIV Infections/EPIDEMIOLOGY/*VIROLOGY HIV-2/*GENETICS Male Molecular Sequence Data Peptide Fragments/*GENETICS Phylogeny Variation (Genetics)/*GENETICS

KWDjournalarticleadolescenceadultaminoacidsequencedna,viral/bloodfemaleguinea-bissau/epidemiologyhumanhivenvelopeproteingp120/KWDgeneticshivinfections/epidemiology/KWDvirologyhiv-2/KWDgeneticsmalemolecularsequencedatapeptidefragments/KWDgeneticsphylogenyvariation(genetics)/KWDgenetics
001230
A00C0946

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