Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. The European Network on the Study of In Utero Transmission of HIV-1. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. The European Network on the Study of In Utero Transmission of HIV-1.

AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1313-8. Unique Identifier : AIDSLINE GENBANK/AF268354
Tscherning-Casper C; Dolcini G; Mauclere P; Fenyo EM; Barre-Sinoussi F; Albert J; Menu E; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden. charlotte.tscherning@mtc.ki.se

Abstract: Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger cohort study in Yaounde, Cameroon. Fourteen of 15 virus variants were shown to be recombinant, whereas a single variant appeared to be nonrecombinant subtype A. Five viruses were subtype A/J recombinants, with env genes derived from subtype A and protease genes derived from subtype J. Seven viruses clustered with reference sequences for CRF02 AG(IbNG) in both the env and protease gene fragments, and were thus subtype A/G recombinants. Two variants displayed even more complex recombination patterns. Phylogenetic analyses indicated that the five subtype A/J recombinants might be the first representatives of a previously unrecognized CRF.

Keywords: JOURNAL ARTICLE Cameroon/EPIDEMIOLOGY DNA, Viral/BLOOD Female Gene Products, env/GENETICS Human HIV Infections/EPIDEMIOLOGY/*VIROLOGY HIV Protease/GENETICS HIV-1/*CLASSIFICATION/*GENETICS Molecular Sequence Data Phylogeny Pregnancy Pregnancy Complications, Infectious/*VIROLOGY Recombination, Genetic/*GENETICS Sequence Analysis, DNA Support, Non-U.S. Gov't Variation (Genetics)

KWDjournalarticlecameroon/epidemiologydna,viral/bloodfemalegeneproducts,env/geneticshumanhivinfections/epidemiology/KWDvirologyhivprotease/geneticshiv-1/KWDclassification/KWDgeneticsmolecularsequencedataphylogenypregnancypregnancycomplications,infectious/KWDvirologyrecombination,genetic/KWDgeneticssequenceanalysis,dnasupport,non-uKWDsKWDgov'tvariation(genetics)
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A00C0945

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