Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.

AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1319-24. Unique Identifier : AIDSLINE GENBANK/AF252111
Fonjungo PN; Mpoudi EN; Torimiro JN; Alemnji GA; Eno LT; Nkengasong JN; Gao F; Rayfield M; Folks TM; Pieniazek D; Lal RB; HIV/AIDS and Retrovirology Branch, Division of AIDS, STD and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.

Abstract: Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41. 98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unlinked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in this population.

Keywords: JOURNAL ARTICLE Amino Acid Sequence Cameroon/EPIDEMIOLOGY Gene Products, pol/GENETICS Human HIV Core Protein p24/GENETICS HIV Envelope Protein gp120 HIV Envelope Protein gp41/*GENETICS HIV Infections/EPIDEMIOLOGY/*VIROLOGY HIV-1/CLASSIFICATION/*GENETICS Molecular Sequence Data Peptide Fragments Phylogeny Sequence Analysis, DNA Variation (Genetics)/*GENETICS

KWDjournalarticleaminoacidsequencecameroon/epidemiologygeneproducts,pol/geneticshumanhivcoreproteinp24/geneticshivenvelopeproteingp120hivenvelopeproteingp41/KWDgeneticshivinfections/epidemiology/KWDvirologyhiv-1/classification/KWDgeneticsmolecularsequencedatapeptidefragmentsphylogenysequenceanalysis,dnavariation(genetics)/KWDgenetics
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A00C0944

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