Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.

Stem Cells. 2000;18(4):230-44. Unique Identifier : AIDSLINE MED/20382679
Sewell AK; Price DA; Oxenius A; Kelleher AD; Phillips RE; The Nuffield Department of Medicine, John Radcliffe Hospital,; Oxford, UK. asewell@gwmail.jr2.ox.ac.uk

Abstract: Effective preventive and therapeutic intervention in individuals exposed to or infected with human immunodeficiency virus (HIV) depends, in part, on a clear understanding of the interactions between the virus and those elements of the host immune response which control viral replication. Recent advances have provided compelling evidence that cytotoxic T lymphocytes (CTLs) constitute an essential component of protective antiretroviral immunity. Here, we review briefly the significance of this work in the context of previous studies, and outline the mechanisms through which HIV evades CTL activity.

Keywords: JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC Animal Disease Models, Animal Human HIV Infections/*IMMUNOLOGY/VIROLOGY HIV-1/*IMMUNOLOGY Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY T-Lymphocytes, Cytotoxic/*IMMUNOLOGY/VIROLOGY

KWDjournalarticlereviewreview,academicanimaldiseasemodels,animalhumanhivinfections/KWDimmunology/virologyhiv-1/KWDimmunologysimianacquiredimmunodeficiencysyndrome/immunologyt-lymphocytes,cytotoxic/KWDimmunology/virology
001230
A00C0928

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