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Eur J Med Res. 2000 Aug 18;5(8):329-33. Unique Identifier : AIDSLINE MED/20416403
Rickerts V; Brodt H; Staszewski S; Stille W; Klinikum der J.W. Goethe Universitat Frankfurt, Med. Klinik III; / Infektiologie, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.; Rickerts@em.uni-frankfurt.de
Abstract: OBJECTIVE: To investigate whether the use of highly active antiretroviral therapy (HAART) is associated with an increased incidence of myocardial infarctions (MI) in HIV infected patients. DESIGN: Retrospective analysis of a cohort of 4993 HIV infected patients treated at our hospital between January, 1 1983 and December, 31 1998. The incidence of myocardial infarctions during 4 observation periods with different antiretroviral treatment strategies are compared. Possible risk factors for MI are evaluated by univariate analysis and using a multiple regression model. RESULTS: 29 patients with MI were diagnosed between 1983 and 1998. The incidence of MI per 1000 patient-years increased from 0.86 (1983-86), 1.14 (1987-90), 0.59 (1991-94) to 3.41 (1995-98) respectively (p = 0.002). Age >40, previous HAART therapy, homo-, or bisexual mode of HIV transmission and previous AIDS diagnosis were significantly associated with MI in univariate analysis. Age >40 and previous HAART therapy remained significantly associated with MI in a multiple regression model. CONCLUSION: The incidence of MI in HIV infected patients increased in our cohort after the introduction of HAART.
001230
A00C0910
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