Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Clin Immunol. 2000 Sep;96(3):280-8. Unique Identifier : AIDSLINE MED/20423217
Stone DM; Norton LK; Chambers JC; Meek WJ; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman, Washington, 99164-7040, USA.
Abstract: Bovine leukemia virus (BLV) is an oncogenic retrovirus in the human T cell leukemia virus family. BLV infects B lymphocytes and induces a nonmalignant persistent lymphocytosis (PL) and leukemia/lymphoma in cattle. There is evidence that CD4 T lymphocytes are activated during BLV infection and promote the development of PL. How CD4 T lymphocytes are activated by BLV infection is not known. We observed that CD4 T lymphocytes from PL cattle proliferated in the presence of autologous, irradiated peripheral blood mononuclear cells (PBMC), whereas no proliferation occurred in cell cultures from BLV-infected non-PL cattle. Proliferation required direct contact with metabolically active irradiated PBMC but was not associated with viral protein expression or inhibited by antibodies to BLV. Unexpectedly, B lymphocytes alone failed to account for the irradiated PBMC stimulation of CD4 T lymphocytes. These observations and the magnitude of the proliferative response suggest that activation is polyclonal and involves mechanisms other than BLV antigen-specific stimulation. Copyright 2000 Academic Press.
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