Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Unique Identifier : AIDSLINE MED/20429902
Rainey PM; Friedland G; McCance-Katz EF; Andrews L; Mitchell SM; Charles C; Jatlow P
Abstract: For opiate-dependent injection drug users infected with HIV, methadone therapy may facilitate adherence to complex highly active antiretroviral therapy (HAART) regimens. Current HAART regimens include one or more nucleoside analogues. We investigated the effects of methadone on the pharmacokinetics of the tablet formulation of didanosine (ddI) and of stavudine (d4T) in 17 study subjects on stable methadone therapy and in 10 untreated controls. Methadone treatment reduced the measured areas under the time-concentration curve (AUC0-6) by 63% for ddI (p =.04) and by 25% for d4T (p =.005) and the extrapolated AUCs
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