2000
- Immunopathology of schistosomiasis mansoni in mice and men [letter]
- Immunol Today. 2000 Sep;21(9):465-6. Unique Identifier : AIDSLINE MED/20411113
- Cheever AW; Hoffmann KF; Wynn TA
- Directions for biomedical research in alcohol and HIV: where are we now and where can we go?
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1197-207. Unique Identifier : AIDSLINE MED/20414615
- Isaki L; Kresina TF; Division of Basic Research, National Institute on Alcohol Abuse; and Alcoholism, National Institutes of Health, Bethesda, Maryland; 20892, USA.
- Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1209-13. Unique Identifier : AIDSLINE MED/20414616
- Bally F; Martinez R; Peters S; Sudre P; Telenti A; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.
- Amino acid substitutions at HIV-1 Gag p7/p1 and p1/p6 cleavage sites may be selected under antiretroviral pressure or represent natural polymorphisms. Whether changes are associated with specific protease (PR) mutation patterns and different clinical evolution has not been investigated. p7/p1 and p1/p6 cleavage site s
- Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1215-21. Unique Identifier : AIDSLINE MED/20414617
- Look MP; Altfeld M; Kreuzer KA; Riezler R; Stabler SP; Allen RH; Sauerbruch T; Rockstroh JK; Department of General Internal Medicine, University of Bonn,; Germany. Look@Uni-Bonn.de
- The chronic immune activation state in HIV disease leads to increased activity of the rate-limiting tryptophan-kynurenine pathway enzyme indoleamine 2,3-dioxygenase (2,3-IDO), thereby increasing the formation of neurotoxic tryptophan metabolites such as kynurenine and quinolinic acid. We investigated whether highly ac
- Genetic analysis of viral variants selected in transmission of human immunodeficiency viruses to newborns.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1223-33. Unique Identifier : AIDSLINE +
- Kliks S; Contag CH; Corliss H; Learn G; Rodrigo A; Wara D; Mullins JI; Levy JA; Cancer Research Institute and Department of Pediatrics, School of; Medicine, University of California, San Francisco 94143, USA.
- Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral
- Natural variation in the amino acid sequence around the HIV type 1 glycoprotein 160 cleavage site and its effect on cleavability, subunit association, and membrane fusion.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1235-45. Unique Identifier : AIDSLINE MED/20414619
- Adams O; Schaal H; Scheid A; Institut fur Medizinische Mikrobiologie und Virologie,; Heinrich-Heine-Universitat, Dusseldorf, Germany.; adamso@uni-duesseldorf.de
- To assess the natural variation of the structure of the cleavage site as well as the N-terminal region of gp41 for the cytopathogenicity of HIV-1, syncytium-inducing (SI) and non-syncytium-inducing (NSI) virus isolates were obtained from HIV-1-infected patients. In addition, the coreceptor usage of the isolates was de
- Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1247-57. Unique Identifier : AIDSLINE MED/20414620
- Hofmann-Lehmann R; Swenerton RK; Liska V; Leutenegger CM; Lutz H; McClure HM; Ruprecht RM; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
- Plasma viral RNA load is a key parameter in disease progression of lentiviral infections. To measure simian immunodeficiency virus (SIV) RNA loads, we have established a quantitative one-tube assay based on TaqMan chemistry. This real-time reverse transcriptase-polymerase chain reaction (RT-PCR) has advantages compare
- Generation of monoclonal antibodies specifically directed against the proximal zinc finger of HIV type 1 NCp7.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1259-67. Unique Identifier : AIDSLINE MED/20414621
- De Rocquigny H; Caneparo A; Dong CZ; Delaunay T; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale,; INSERM U266-CNRS UMR 8600, UFR des Sciences Pharmaceutiques et; Biologiques, Paris, France.
- The HIV-1 NCp7 contains two spatially close zinc fingers, required for the production of infectious particles. To investigate in more detail the function of the zinc finger domain, monoclonal antibodies were generated with a cyclic analog of the NCp7 proximal zinc finger. This analog was shown to bind zinc ions and to
- Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1269-80. Unique Identifier : AIDSLINE MED/20414622
- Isaguliants MG; Gudima SO; Ivanova OV; Levi M; Hinkula J; Garaev MM; Kochetkov SN; Wahren B; D. I. Ivanovsky Institute of Virology, Moscow, Russia.; maria.isaguliants@smi.ki.se
- Genetic immunization may be one way to prime individuals for a subsequent broad anti-HIV-1 immune response. Reverse transcriptase of HIV-1 (RT) presents a selective target for attempts to arrest replication of HIV-1. Rabbits immunized with a plasmid carrying the gene for reverse transcriptase HIV-1 (RT DNA) developed
- Monoclonal antibodies to native HIV type 1 reverse transcriptase and their interaction with enzymes from different subtypes.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1281-94. Unique Identifier : AIDSLINE MED/20414623
- Rytting AS; Akerblom L; Albert J; Unge T; Bjorling E; Al-Khalili L; Gronowitz JS; Kallander CF; Unit of Medical Genetics, Department of Genetics and Pathology,; Uppsala University, BMC, Sweden.
- Recombinant reverse transcriptase (RT) from HIV-1 subtype B was used to produce mouse anti-RT monoclonal antibodies (MAbs). Immunization was done by mixing RT with the ISCOM matrix-forming adjuvant saponin (Quil A). Two different assays, both based on the interaction of native RT and antibodies, were used to monitor t
- Simian-human immunodeficiency virus-associated nephropathy in macaques.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1295-306. Unique Identifier : AIDSLINE MED/20414624
- Stephens EB; Tian C; Dalton SB; Gattone VH 2nd; Department of Microbiology, Molecular Genetics, and Immunology,; University of Kansas Medical Center, Kansas City 66160, USA.; estephen@kumc.edu
- A number of chimeric simian-human immunodeficiency virus (SHIV) viruses containing tat, rev, vpu, and env from HIV-1 (strain HXBc2) in a genetic background of simian immunodeficiency virus (SIV(mac)239) have been derived from the parental nonpathogenic SHIV-4 virus. In this article we examine the renal pathology assoc
- Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1307-12. Unique Identifier : AIDSLINE GENBANK/AJ246945
- Parreira R; Esteves A; Santos C; Piedade J; Venenno T; Canas-Ferreira WF; Unidade de Virologia/Unidade de Parasitologia e Microbiologia; Medicas, Instituto de Higiene e Medicina Tropical, Universidade; Nova de Lisboa, Portugal. Ricardo@ihmt.unl.pt
- The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositi
- Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. The European Network on the Study of In Utero Transmission of HIV-1.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1313-8. Unique Identifier : AIDSLINE GENBANK/AF268354
- Tscherning-Casper C; Dolcini G; Mauclere P; Fenyo EM; Barre-Sinoussi F; Albert J; Menu E; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden. charlotte.tscherning@mtc.ki.se
- Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger co
- Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1319-24. Unique Identifier : AIDSLINE GENBANK/AF252111
- Fonjungo PN; Mpoudi EN; Torimiro JN; Alemnji GA; Eno LT; Nkengasong JN; Gao F; Rayfield M; Folks TM; Pieniazek D; Lal RB; HIV/AIDS and Retrovirology Branch, Division of AIDS, STD and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H
- Guidelines for the diagnosis and management of HIV disease.
- J Am Acad Nurse Pract. 1999 Dec;11(12):519-26. Unique Identifier : AIDSLINE MED/20456023
- Whyte J 4th; Dawson SB; Beaufort Naval Hospital, SC, USA.
- HIV/AIDS, WHO Western Pacific Region, revised 1999 estimates.
- Wkly Epidemiol Rec. 2000 Aug 18;75(33):266-8. Unique Identifier : AIDSLINE MED/20430648
- Adenoids provide a microenvironment for the generation of CD4(+), CD45RO(+), L-selectin(-), CXCR4(+), CCR5(+) T lymphocytes, a lymphocyte phenotype found in the middle ear effusion.
- Int Immunol. 2000 Sep;12(9):1235-43. Unique Identifier : AIDSLINE MED/20425414
- Mattila PS; Nykanen A; Eloranta M; Tarkkanen J; Department of Otorhinolaryngology, Helsinki University Central; Hospital, Haartmaninkatu 4 E, 00290 Helsinki, Finland.
- Adenoidectomy in children with otitis media with effusion reduces inflammation in the middle ear by an unknown mechanism. Potentially, the adenoids of these children may serve as a site for the differentiation of lymphocytes, which after entering blood circulation eventually extravasate in the middle ear mucosa and th
- Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications.
- Int Immunol. 2000 Sep;12(9):1293-302. Unique Identifier : AIDSLINE MED/20425420
- Dela Cruz CS; Tan R; Rowland-Jones SL; Barber BH; Department of Immunology and Institute of Medical Science,; University of Toronto, Medical Sciences Building, 1 King's; College Circle, Ontario M5S 1A8, Canada.
- Vigorous HIV-1-specific CD8(+) cytotoxic T lymphocyte (CTL) responses play an important role in the control of HIV-1 replication and the induction of a strong, broadly cross-reactive CTL response remains an important goal of HIV vaccine development. It is known that the display of high levels of class I MHC-viral pept
- Influence of nucleotide polymorphisms in the CCR2 gene and the CCR5 promoter on the expression of cell surface CCR5 and CXCR4.
- Int Immunol. 2000 Sep;12(9):1311-8. Unique Identifier : AIDSLINE MED/20425422
- Shieh B; Liau YE; Hsieh PS; Yan YP; Wang ST; Li C; Department of Biochemistry, Chung Shan Medical and Dental; College, No. 110, Section 1, Chien Kuo North Road, Taichung 402,; Taiwan, ROC.
- Polymorphisms in the CCR2 gene (CCR2-64I) and the CCR5 promoter (pCCR5-59029G) have been correlated with slower HIV-1 disease progression. How these polymorphisms influence the rate of AIDS progression has remained unclear. We have therefore investigated whether these nucleotide polymorphisms will reduce the expressio
- Affinity of thymic self-peptides for the TCR determines the selection of CD8(+) T lymphocytes in the thymus.
- Int Immunol. 2000 Sep;12(9):1353-63. Unique Identifier : AIDSLINE MED/20425427
- Ober BT; Hu Q; Opferman JT; Hagevik S; Chiu N; Wang CR; Ashton-Rickardt PG; Department of Pathology, University of Chicago, 924 E. 57th; Street, R414, IL 60637, USA.
- Experiments with synthetic antigen peptides have suggested that a critical parameter that determines the developmental fate of an immature thymocyte is the affinity of interaction between TCR and self-peptide/MHC expressed on thymic stromal cells. To test the physiological relevance of this model for thymocyte develop
- Monocyte inflammatory protein-1 alpha facilitates priming of CD8(+) T cell responses to exogenous viral antigen.
- Int Immunol. 2000 Sep;12(9):1365-70. Unique Identifier : AIDSLINE MED/20425428
- Flesch IE; Stober D; Schirmbeck R; Reimann J; Department of Medical Microbiology and Immunology, University of; Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
- Dendritic cells (DC) derived from bone marrow precursors of BALB/c or C57BL/6 mice in low-serum cultures supplemented with granulocyte macrophage colony stimulating factor and Flt(3) ligand were pulsed in vitro with hepatitis B surface antigen (HBsAg) particles. DC processed exogenous HBsAg and presented its MHC class
- Mandibular fracture after wire suspension reduction technique in patient with HIV [letter]
- Br J Oral Maxillofac Surg. 2000 Aug;38(4):397. Unique Identifier : AIDSLINE MED/20380803
- Rodriguez-Recio O; Junquera LM; Calvo N
- Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: roles of the beta 8-alpha E loop in fidelity, processivity, and substrate interactions.
- Biochemistry. 2000 Sep 5;39(35):10684-94. Unique Identifier : AIDSLINE MED/20435243
- Weiss KK; Isaacs SJ; Tran NH; Adman ET; Kim B; Department of Microbiology and Immunology, University of; Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester,; New York 14642, USA.
- Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a putative source of the genomic hypermutation that promotes rapid evolution of HIV-1. To understand the molecular strategies that create a highly mutagenic DNA polymerase active site in HIV-1 RT, we investigated the roles of four residues in th
- Recognition properties of V3-specific antibodies to V3 loop peptides derived from HIV-1 gp120 presented in multiple conformations.
- Biochemistry. 2000 Sep 5;39(35):10866-76. Unique Identifier : AIDSLINE MED/20435264
- Huisman JG; Carotenuto A; Labrijn AF; Papavoine CH; Laman JD; Schellekens MM; Koppelman MH; Hilbers CW; CLB, Sanquin Blood Supply Foundation, Laboratory for Clinical and; Experimental Immunology, Department of Pathophysiology of Plasma; Proteins, Amsterdam, The Netherlands.
- To identify structural constraints and amino acid sequences important for antibody recognition of the third variable domain (V3) of HIV-1 gp120, we have studied the solution conformation of three 35-mer circular V3 loop peptides derived from HIV-1 strains which differ in syncytium- (SI) and non-syncytium-inducing (NSI
- Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C.
- Eur Cytokine Netw. 2000 Jun;11(2):177-84. Unique Identifier : AIDSLINE MED/20363558
- Balian A; Naveau S; Zou W; Durand-Gasselin I; Bouchet L; Foussat A; Galanaud P; Chaput JC; Emilie D; Hopital Antoine-Beclere, Insitut Paris-Sud sur les Cytokines,; 92140 Clamart, France. axel.balian@abc.ap-hop-paris.fr
- It would be of great value to be able to predict, before the initiation of treatment, which patients with hepatitis C virus-induced chronic hepatitis will be cured by interferon-alpha (IFN-alpha). Competitive RT-PCR was used to evaluate spontaneous expression of the perforin gene, a marker of cytotoxic cell activation
- Hyperglycemia associated with protease inhibitors in an urban HIV-infected minority patient population.
- Ann Pharmacother. 2000 May;34(5):580-4. Unique Identifier : AIDSLINE MED/20308923
- Dever LL; Oruwari PA; Figueroa WE; O'Donovan CA; Eng RH; Infectious Diseases Clinic, Veterans Affairs New Jersey Health; Care System, East Orange 07018, USA.; dever.lisa@east-orange.va.gov
- BACKGROUND: Hyperglycemia and new-onset diabetes mellitus have been reported to occur in HIV-infected patients treated with protease inhibitors . OBJECTIVE: To determine the effect of protease inhibitor therapy on serum glucose in a predominantly minority patient pop
- Treatment of listeriosis.
- Ann Pharmacother. 2000 May;34(5):656-61. Unique Identifier : AIDSLINE MED/20308935
- Temple ME; Nahata MC; Infectious Disease and Pediatric Pharmacotherapy, College of; Pharmacy, The Ohio State University, Columbus 43210, USA.
- OBJECTIVE: To review the most currently accepted treatment options for the treatment of listeriosis. DATA SOURCES: Clinical literature was accessed through MEDLINE (1966-October 1999). Key search terms included Listeria monocytogenes, food-borne illness, penicillins, fluoroquinolones, cephalosporins, and vancomycin. D
- [Management and care of severely ill patients in ambulatory care nursing--results of an evaluation study]
- Gesundheitswesen. 2000 May;62(5):264-9. Unique Identifier : AIDSLINE MED/20352338
- Schaeffer D; Ewers M; Institut fur Pflegewissenschaft, Universitat Bielefeld.; ipw@uni-bielefeld.de
- The last few years have seen numerous attempts to expand outpatient nursing and adapt it to the changing health problems of the population. Even so, outpatient nursing care for severely ill patients and those with complex nursing needs still has its shortcomings. Today, it may well be the case that these patients, too
- Reducing the risk of infection from plasma products: specific preventative strategies.
- Blood Rev. 2000 Jun;14(2):94-110. Unique Identifier : AIDSLINE MED/20456244
- Burnouf T; Radosevich M; Human Plasma Product Services (HPPS), Lille, France.; tburnou@attglobal.net
- Collection and testing procedures of blood and plasma that are designed to exclude donations contaminated by viruses provide a solid foundation for the safety of all blood products. Plasma units may be collected from a selected donor population, contributing to the exclusion of individuals at risk of carrying infectio
- Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.
- Stem Cells. 2000;18(4):230-44. Unique Identifier : AIDSLINE MED/20382679
- Sewell AK; Price DA; Oxenius A; Kelleher AD; Phillips RE; The Nuffield Department of Medicine, John Radcliffe Hospital,; Oxford, UK. asewell@gwmail.jr2.ox.ac.uk
- Effective preventive and therapeutic intervention in individuals exposed to or infected with human immunodeficiency virus (HIV) depends, in part, on a clear understanding of the interactions between the virus and those elements of the host immune response which control viral replication. Recent advances have provided
- Health-related quality of life among people with HIV disease: results from the Multicenter AIDS Cohort Study.
- Qual Life Res. 2000 Feb;9(1):55-63. Unique Identifier : AIDSLINE MED/20436501
- Bing EG; Hays RD; Jacobson LP; Chen B; Gange SJ; Kass NE; Chmiel JS; Zucconi SL; Department of Psychiatry, Charles R. Drew University of Medicine; & Science, Los Angeles, CA 90059, USA.
- To examine the effect of HIV status, symptomatology and CD4+ lymphocyte level on health-related quality of life, the Medical Outcomes Study Short-Form Health Survey (SF-36) was administered to 2,295 gay men enrolled in the Multicenter AIDS Cohort Study (MACS) in 1994. Distinct physical and mental health factors of the
- [Lymphomas in children infected with HIV-1]
- Arch Pediatr. 2000 Jul;7(7):738-44. Unique Identifier : AIDSLINE MED/20397084
- Gandemer V; Verkarre V; Quartier P; Brousse N; Blanche S; Unite d'immunologie-hematologie pediatrique, hopital; Necker-Enfants-malades, Paris, France.
- PURPOSE: To describe the features of lymphoma in human immunodeficiency virus (HIV)-infected children, their treatments and the outcome of patients. RESULTS: We analyzed seven HIV-infected children (four by mother-to-child transmission and three by transfusion) (25 months to 18.5 years old) with lymphoma (one Hodgkin
- Gene therapy and the two faces of HIV [editorial]
- Gene Ther. 2000 Aug;7(16):1351-2. Unique Identifier : AIDSLINE MED/20434539
- Wong-Staal F; Buchschacher GL Jr
- Antisense RNA sequences targeting the 5' leader packaging signal region of human immunodeficiency virus type-1 inhibits viral replication at post-transcriptional stages of the life cycle.
- Gene Ther. 2000 Aug;7(16):1362-8. Unique Identifier : AIDSLINE MED/20434541
- Chadwick DR; Lever AM; Department of Medicine, University of Cambridge, Addenbrooke's; Hospital, UK.
- Antisense RNA has proven a potent inhibitor of gene expression and has the potential to inhibit retroviral replication at a number of stages in the virus life cycle by targeting both viral and cellular RNA sequences. Antisense RNA complementary to three target regions in the 5 leader/LTR of human immunodeficiency vir
- Improved titers of HIV-based lentiviral vectors using the SRV-1 constitutive transport element.
- Gene Ther. 2000 Aug;7(16):1421-4. Unique Identifier : AIDSLINE MED/20434549
- Mautino MR; Keiser N; Morgan RA; Clinical Gene Therapy Branch, National Human Genome Research; Institute, National Institutes of Health, Bethesda, MD; 20892-1851, USA.
- The development of lentiviral vectors that use Rev-independent mechanisms of nuclear export for their genomic RNA could facilitate the construction of novel anti-HIV vectors. We have improved the titers of Rev-independent lentiviral vectors having the SRV-1 CTE by mutating the major splice donor and acceptor sites pre
- Eradication of established tumors by CD8+ T cell adoptive immunotherapy.
- Immunity. 2000 Aug;13(2):265-76. Unique Identifier : AIDSLINE MED/20434848
- Hanson HL; Donermeyer DL; Ikeda H; White JM; Shankaran V; Old LJ; Shiku H; Schreiber RD; Allen PM; Department of Pathology and Center for Immunology, Washington; University School of Medicine, St. Louis, Missouri 63110, USA.
- We generated the DUC18 T cell receptor transgenic mouse expressing an H-2Kd -restricted transgenic T cell receptor specific for the syngeneic CMS5 fibrosarcoma rejection antigen mutated ERK2(136-144). DUC18 mice were capable of specifically eliminating lethal CMS5 tumor challenges, and transfer of DUC18 splenocytes to
- [Cytokine and cytokine receptor deficiencies causing defects in T cell/Th 1 cell differentiation and function]
- Nihon Rinsho Meneki Gakkai Kaishi. 2000 Jun;23(3):173-80. Unique Identifier : AIDSLINE MED/20373729
- Hara T; Sasaki Y; Nomura A; Takada H; Department of Pediatrics, Graduate School of Medical Sciences,; Kyushu University.
- Convergence of natural and artificial evolution on an RNA loop-loop interaction: the HIV-1 dimerization initiation site.
- RNA. 2000 Sep;6(9):1267-76. Unique Identifier : AIDSLINE MED/20452233
- Lodmell JS; Ehresmann C; Ehresmann B; Marquet R; Institut de Biologie Moleculaire et Cellulaire, Unite Propre de; Recherche 9002 du Centre National de la Recherche Scientifique,; Strasbourg, France.
- Loop-loop interactions among nucleic acids constitute an important form of molecular recognition in a variety of biological systems. In HIV-1, genomic dimerization involves an intermolecular RNA loop-loop interaction at the dimerization initiation site (DIS), a hairpin located in the 5 noncoding region that contains
- Coupled in vitro synthesis and splicing of RNA polymerase II transcripts.
- RNA. 2000 Sep;6(9):1325-34. Unique Identifier : AIDSLINE MED/20452238
- Ghosh S; Garcia-Blanco MA; Department of Genetics, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- Compelling in vivo studies suggest a tight functional linkage between RNA polymerase II transcription and premessenger RNA splicing. At present, the specific interactions involved in this coupling are poorly understood and deserve investigation. To this end, we developed an in vitro system that permits study of couple
- Reversible pulmonary hypertension in POEMS syndrome--another etiology of triggered pulmonary vasculopathy?
- Can J Cardiol. 2000 Aug;16(8):1007-12. Unique Identifier : AIDSLINE MED/20435621
- Paciocco G; Bossone E; Erba H; Rubenfire M; Instituto di Malattie dell'App Respiratorio, Italy.
- Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome, a plasma cell dyscrasia associated with pulmonary hypertension, has been treated in the past with anticytokine strategies with a poor outcome. A patient is described who had POEMS syndrome with precapillary pulmonary
- CAM and HIV/AIDS: the importance of complementarity [comment]
- Altern Ther Health Med. 2000 Sep;6(5):30-1. Unique Identifier : AIDSLINE MED/20433537
- Targ E; Complementary Medicine Research Institute, California Pacific; Medical Center, USA.
- Acupuncture for symptom relief in HIV-positive adults: lessons learned from a pilot study [see comments]
- Altern Ther Health Med. 2000 Sep;6(5):33-42. Unique Identifier : AIDSLINE MED/20433538
- Beal MW; Nield-Anderson L; Yale University School of Nursing, New Haven, Conn., USA.
- CONTEXT: Although acupuncture is used by many people with HIV disease as a complementary treatment to Western medicine, there is a lack of scientifically sound research on patient responses and outcomes. OBJECTIVE: To explore the feasibility of conducting a larger study investigating the efficacy of acupuncture on sym
- Alternative or complementary? Nonallopathic therapies for HIV/AIDS [see comments]
- Altern Ther Health Med. 2000 Sep;6(5):44-52. Unique Identifier : AIDSLINE MED/20433539
- de Visser R; Ezzy D; Bartos M; Australian Research Centre in Sex, Health, and Society, La Trobe; University, Melbourne.
- CONTEXT: Many people with HIV/AIDS use alternative therapies. Do they choose alternative therapies instead of allopathic therapies? OBJECTIVE: To examine patterns of use of allopathic therapies and alternative therapies among people living with HIV/AIDS. DESIGN: Cross-sectional survey of convenience sample. SETTING: N
- Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites.
- Cancer Res. 2000 Sep 1;60(17):4939-45. Unique Identifier : AIDSLINE MED/20441594
- Mori N; Ueda A; Ikeda S; Yamasaki Y; Yamada Y; Tomonaga M; Morikawa S; Geleziunas R; Yoshimura T; Yamamoto N; Department of Preventive Medicine and AIDS Research, Institute of; Tropical Medicine, Nagasaki University, Japan.; n-mori@net.nagasaki-u.ac.jp
- Infection by human T-cell leukemia virus type (HTLV) I leads to adult T-cell leukemia and is also associated with the neurodegenerative disease HTLV-I-associated myelopathy/tropical spastic paraparesis. Leukocytes are attracted to sites of inflammation by chemokines. One such chemokine is monocyte chemoattractant prot
- Local injections of OK432 can help the infiltration of adoptively transferred CD8+ T cells into the tumor sites and synergistically induce the local production of Th1-type cytokines and CXC3 chemokines.
- Cancer Immunol Immunother. 2000 Sep;49(7):361-8. Unique Identifier : AIDSLINE MED/20452091
- Tatsugami K; Tamada K; Abe K; Harada M; Nomoto K; Department of Immunology, Medical Institute of Bioregulation,; Kyushu University, Fukuoka, Japan.
- The effect of local injections with streptococcal preparation OK432 on the antitumor effect induced by adoptive immunotherapy (AIT) was investigated. Draining lymph node cells on day 14 after B7-P815 inoculation were used for AIT after in vitro stimulation. AIT on days 7 and 10 showed no effect on the growth of s.c. e
- How Latino American and European American adolescents discuss conflicts, sexuality, and AIDS with their mothers.
- Dev Psychol. 2000 May;36(3):315-25. Unique Identifier : AIDSLINE MED/20289822
- Lefkowitz ES; Romo LF; Corona R; Au TK; Sigman M; Department of Human Development and Family Studies, Pennsylvania; State University, University Park 16802, USA. EXL20@psu.edu
- The authors examined how the structure of mother-adolescent conversations differs by ethnic group, age, and dyadic and individual factors. Mother-adolescent dyads of European or Latino descent participated in conversations and reported on their relationship and AIDS knowledge. Latina American mothers dominated convers
- Positive influence of the Delta32CCR5 allele on response to highly active antiretroviral therapy (HAART) in HIV-1 infected patients.
- Eur J Med Res. 2000 Aug 18;5(8):323-8. Unique Identifier : AIDSLINE MED/20416402
- Kasten S; Goldwich A; Schmitt M; Rascu A; Grunke M; Dechant C; Kalden JR; Harrer T; Department of Medicine III, University of Erlangen-Nuremberg,; Krankenhausstrasse 12, D-91054 Erlangen, Germany.
- The heterozygous 32 base pair deletion of the chemokine receptor 5 (Delta32CCR5) has been associated with a more benign course of HIV-1-infection. To study the influence of Delta32CCR5 on the response to antiviral therapy we analyzed the presence of Delta32CCR5 by PCR in PBMC from 107 randomly selected HIV-1-infected
- Incidence of myocardial infarctions in HIV-infected patients between 1983 and 1998: the Frankfurt HIV-cohort study.
- Eur J Med Res. 2000 Aug 18;5(8):329-33. Unique Identifier : AIDSLINE MED/20416403
- Rickerts V; Brodt H; Staszewski S; Stille W; Klinikum der J.W. Goethe Universitat Frankfurt, Med. Klinik III; / Infektiologie, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.; Rickerts@em.uni-frankfurt.de
- OBJECTIVE: To investigate whether the use of highly active antiretroviral therapy (HAART) is associated with an increased incidence of myocardial infarctions (MI) in HIV infected patients. DESIGN: Retrospective analysis of a cohort of 4993 HIV infected patients treated at our hospital between January, 1 1983 and Decem
- Spleen necrosis virus-derived C-type retroviral vectors for gene transfer to quiescent cells.
- Nat Biotechnol. 2000 Jun;18(6):623-9. Unique Identifier : AIDSLINE MED/20296926
- Parveen Z; Krupetsky A; Engelstadter M; Cichutek K; Pomerantz RJ; Dornburg R; The Dorrance H. Hamilton Laboratories, Thomas Jefferson; University, Division of Infectious Diseases, Center for Human; Virology, 1020 Locust Street, Suite 329, Philadelphia, PA 19107,; USA.
- Gene therapy applications of retroviral vectors derived from C-type retroviruses have been limited to introducing genes into dividing target cells. Here, we report genetically engineered C-type retroviral vectors derived from spleen necrosis virus (SNV), which are capable of infecting nondividing cells. This has been
- Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5.
- Nat Biotechnol. 2000 Jun;18(6):649-54. Unique Identifier : AIDSLINE MED/20296931
- Mirzabekov T; Kontos H; Farzan M; Marasco W; Sodroski J; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, 44 Binney St., Boston, MA 02115, USA.
- Seven-transmembrane segment, G protein-coupled receptors play central roles in a wide range of biological processes, but their characterization has been hindered by the difficulty of obtaining homogeneous preparations of native protein. We have created paramagnetic proteoliposomes containing pure and oriented CCR5, a
- A randomised controlled trial of different approaches to universal antenatal HIV testing: uptake and acceptability and Annex: Antenatal HIV testing - assessment of a routine voluntary approach.
- Health Technol Assess. 1999;3(4):1-112. Unique Identifier : AIDSLINE MED/99279606
- Simpson WM; Johnstone FD; Boyd FM; Goldberg DJ; Hart GJ; Gormley SM; Hamilton BA; Department of Obstetrics and Gynaecology, Centre for Reproductive; Biology, The University of Edinburgh, Edinburgh, UK.
- Molecular localisation of a G-protein mRNA using differential display and in situ hybridization.
- Brain Res Brain Res Protoc. 2000 Jul;5(3):290-7. Unique Identifier : AIDSLINE MED/20368875
- Wilkinson R; Tscharke D; Simmons A; Infectious Diseases Laboratories, Institute of Medical and; Veterinary Science, Frome Road, South Australia 5000, Adelaide,; Australia. ray.wilkinson@imvs.sa.gov.au
- Defining molecular repertoires within virally infected tissues of the nervous system may provide insight into the pathogenesis of, and immunity to, neurotropic viruses. Here we report the application of such a method, namely mRNA differential display (DD), to the identification of mRNAs that are expressed at different
- [Polymorphism of human alleles associated with genetic resistance against HIV-1 infection and its implications]
- Chung Hua I Hsueh I Chuan Hsueh Tsa Chih. 2000 Aug;17(4):285-7. Unique Identifier : AIDSLINE MED/20392334
- Wang F; Liu D; Department of Bioengineering, Beijing Institute of Infectious; Diseases, P. R. China. fushengw@public.bta.net.cn
- To investigate the genetic susceptibility of different ethnic populations to human immunodeficiency virus-1(HIV-1) infection by comparing the characteristics of gene mutation frequency and polymorphism of CCR5, CCR2 and SDF-1 alleles among different nationalities in the world. The recently reported data on AIDS progre
- Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine.
- Altern Med Rev. 2000 Aug;5(4):290-305. Unique Identifier : AIDSLINE MED/20413353
- Patrick L
- The role of antioxidants in preventing apoptosis and viral activation in HIV is well documented. N-acetylcysteine, glutathione, and alpha-lipoic acid have been shown to interrupt the process of viral activation and CD4 cell death. L-glutamine has been shown to improve glutathione levels and significantly increase lean
- Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients [see comments]
- J Peripher Nerv Syst. 1997;2(3):250-2. Unique Identifier : AIDSLINE MED/20427471
- Scarpini E; Sacilotto G; Baron P; Cusini M; Scarlato G; Department of Clinical Neurology, IRCCS-Ospedale Maggiore; Policlinico, University of Milano, Italy.
- We studied the effects of acetyl-L-carnitine on pain in 16 HIV+ patients affected by painful distal symmetrical neuropathy. Patients were treated with 0.5-1 gr per day of acetyl-L-carnitine either i.m. or i.v. for 3 weeks. Pain intensity was measured before and after the treatment by the Huskisson s analogic scale. Te
- Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide.
- Cancer Chemother Pharmacol. 2000;46(2):135-41. Unique Identifier : AIDSLINE MED/20426299
- Kestell P; Zhao L; Baguley BC; Palmer BD; Muller G; Paxton JW; Ching LM; Auckland Cancer Society Research Centre, University of Auckland; Medical School, New Zealand.
- BACKGROUND: 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), an investigative drug currently in clinical trial, acts on tumour vasculature through the induction of cytokines. Coadministration of thalidomide, a modulator of cytokine production, potentiates the antitumour activity of DMXAA against the murine Colon 38 carci
- Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.
- Clin Immunol. 2000 Sep;96(3):187-97. Unique Identifier : AIDSLINE MED/20423206
- Laux I; Khoshnan A; Tindell C; Bae D; Zhu X; June CH; Effros RB; Nel A; Division of Clinical Immunology and Allergy, UCLA, Los Angeles,; California, 90095, USA.
- Since CD28 costimulation is critical for T-cell activation, there is great interest in CD28 as a target for immuntherapeutic approaches. We show that stimulation of human CD4(+) and CD8(+) T-cells differs in their responsiveness to stimulation with anti-CD3/CD28-coated beads, as surrogate antigen-presenting cells. Whi
- Combined nasal administration of encephalitogenic myelin basic protein peptide 68-86 and IL-10 suppressed incipient experimental allergic encephalomyelitis in Lewis rats.
- Clin Immunol. 2000 Sep;96(3):205-11. Unique Identifier : AIDSLINE MED/20423208
- Xu LY; Yang JS; Huang YM; Levi M; Link H; Xiao BG; Experimental Neurobiology Unit and Neuroimmunology Unit,; Karolinska Institute, Stockholm, Sweden.
- Mucosal administration of low doses of myelin basic protein (MBP) peptide 68-86 (MBP 68-86) or anti-inflammatory cytokine IL-10 effectively prevented experimental allergic encephalomyelitis (EAE), but failed to suppress the disease if given after 7 days postimmunization (p.i.), i.e., after T cell priming had occurred.
- The increase of IFN-gamma production through aging correlates with the expanded CD8(+high)CD28(-)CD57(+) subpopulation.
- Clin Immunol. 2000 Sep;96(3):230-5. Unique Identifier : AIDSLINE MED/20423211
- Bandres E; Merino J; Vazquez B; Inoges S; Moreno C; Subira ML; Sanchez-Ibarrola A; School of Medicine, Clinica Universitaria, Pamplona, Spain.
- The use of flow cytometry to detect intracellular cytokines at the single cell level has the potential to quantify cytokine production together with the possibility of phenotypic identification of the cell population concerned. The unbalanced presence of intracellular cytokines produced by T cells has been recognized
- N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.
- Clin Immunol. 2000 Sep;96(3):236-42. Unique Identifier : AIDSLINE MED/20423212
- Le Y; Jiang S; Hu J; Gong W; Su S; Dunlop NM; Shen W; Li B; Ming Wang J; Laboratory of Molecular Immunoregulation, National Cancer; Institute-Frederick Cancer Research and Development Center,; Frederick, Maryland, 21702, USA.
- Human immunodeficiency virus type 1 (HIV-1) envelope protein gp41 mediates viral fusion with human host cells. In this study we show that N36, a synthetic peptide derived from the N-terminus of gp41, induced directional migration and calcium mobilization in human monocytes and neutrophils. The activity of N36 on phago
- Activation of human microglial cells by HIV-1 gp41 and Tat proteins.
- Clin Immunol. 2000 Sep;96(3):243-51. Unique Identifier : AIDSLINE MED/20423213
- Sheng WS; Hu S; Hegg CC; Thayer SA; Peterson PK; Department of Pharmacology, Institute for Brain and Immune; Disorders, Minneapolis, Minnesota, 55404, USA.
- The viral proteins, Tat (HIV-1 nuclear protein) and gp41 (HIV-1 coat protein), detected in the brains of HIV-1-infected patients have been shown to be neurotoxic. We investigated the effects of HIV-1 Tat and gp41 proteins on cytokine, chemokine, and superoxide anion (O(-)(2)) production by microglia, the resident macr
- CD4 T lymphocyte activation in BLV-induced persistent B lymphocytosis in cattle.
- Clin Immunol. 2000 Sep;96(3):280-8. Unique Identifier : AIDSLINE MED/20423217
- Stone DM; Norton LK; Chambers JC; Meek WJ; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman, Washington, 99164-7040, USA.
- Bovine leukemia virus (BLV) is an oncogenic retrovirus in the human T cell leukemia virus family. BLV infects B lymphocytes and induces a nonmalignant persistent lymphocytosis (PL) and leukemia/lymphoma in cattle. There is evidence that CD4 T lymphocytes are activated during BLV infection and promote the development o
- Discrepancy between Ga-67 citrate and F-18 fluorodeoxyglucose positron emission tomographic scans in pulmonary infection.
- Clin Nucl Med. 2000 Jun;25(6):490-1. Unique Identifier : AIDSLINE MED/20294699
- Goswami GK; Jana S; Santiago JF; Buyukdereli G; Salem SS; Heiba S; Abdel-Dayem HM; Department of Radiology, Saint Vincents Hospital, New York; Medical College, Valhalla 10011, USA.
- The authors describe a patient with the acquired immunodeficiency syndrome who had active pulmonary tuberculosis and was receiving anti-tuberculosis treatment. High-grade fever and a right-sided pleural effusion had recently developed. Results of a Ga-67 scan were negative for any focal infection in the chest. Fluorin
- Rapid communication: development of in vitro resistance to macrophage-tropic- and T-cell-line-adapted HIV-1 strains among HIV-positive volunteers treated with highly active antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):197-202. Unique Identifier : AIDSLINE MED/20429896
- Castillo RC; Arango-Jaramillo S; John R; Turner BC; Zimmerman E; Schwartz DH; Department of Molecular Microbiology and Immunology, The Johns; Hopkins University, School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.
- We have described a peripheral blood mononuclear cell (PBMC) culture system in which control of endogenous virus and resistance to exogenous HIV-1 correlates with low viremia among HIV-1-positive people. Nineteen patients remained consistently resistant or susceptible for more than 5 years of follow-up. On the fifth y
- Polymerase chain reaction-based assay for antibody-mediated neutralization of HIV-1 reveals a population of nonneutralized virus undetected by conventional p24 assay.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):203-10. Unique Identifier : AIDSLINE MED/20429897
- Achkar JM; Wang XH; Nyambi P; Gorny MK; Zolla-Pazner S; Bandres JC; New York Veterans Affairs Medical Center and Departments of; Medicine and Pathology, New York University, New York City, New; York 10010, USA.
- To be successful with strategies involving passive immunization or the generation of neutralizing antibodies against HIV, it is crucial that we improve our understanding of the process of antibody-mediated HIV neutralization. We have used a neutralization assay based on polymerase chain reaction (PCR) that is more rap
- Mortality for liver disease in patients with HIV infection: a cohort study.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):211-7. Unique Identifier : AIDSLINE MED/20429898
- Puoti M; Spinetti A; Ghezzi A; Donato F; Zaltron S; Putzolu V; Quiros-Roldan E; Zanini B; Casari S; Carosi G; II Divisione di Malattie Infettive, Azienda Spedali Civili,; Brescia, Italy. puoti_brambilla@iol.it
- We undertook this study to assess the association between the various potential causes of liver disease in HIV-seropositive patients and mortality due to liver failure. Three hundred and eight in-hospital deaths were observed from 1987 to December 1995 in a prospectively followed cohort of 1894 HIV-seropositive patien
- Association of race and gender with HIV-1 RNA levels and immunologic progression.
- Unique Identifier : AIDSLINE MED/20429899
- Anastos K; Gange SJ; Lau B; Weiser B; Detels R; Giorgi JV; Margolick JB; Cohen M; Phair J; Melnick S; Rinaldo CR; Kovacs A; Levine A; Landesman S; Young M; Munoz A; Greenblatt RM; Montefiore Medical Center, Bronx, New York 10467, USA.; kanasto@aol.com
- CONTEXT: HIV-1 RNA and lymphocyte subset levels are the principal indications for antiretroviral treatment. Past reports have differed with regard to the effect of gender and race on these measures and in measures of disease progression. OBJECTIVE: To assess racial and gender differences in HIV-1 RNA levels and CD4+ l
- Economic evaluation of drug resistance genotyping for the adaptation of treatment in HIV-infected patients in the VIRADAPT study.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):227-31. Unique Identifier : AIDSLINE MED/20429900
- Chaix C; Grenier-Sennelier C; Clevenbergh P; Durant J; Schapiro JM; Dellamonica P; Durand-Zaleski I; Public Health, Henri Mondor, AP-HP, Paris, France.
- BACKGROUND: Costs of antiretroviral therapy for HIV-infected patients have increased at a time when most countries are attempting to contain health care costs. Part of this increase results from HIV drug resistance associated with virologic failure and a subsequent shift to more complex and costly therapies. Genotypic
- Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1-infected Italian patients with virologic failure.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):232-40. Unique Identifier : AIDSLINE +
- Balotta C; Violin M; Monno L; Bagnarelli P; Riva C; Facchi G; Berlusconi A; Lippi M; Rusconi S; Clementi M; Galli M; Angarano G; Moroni M; Institute of Infectious and Tropical Diseases, L. Sacco Hospital,; University of Milan, Milan, Italy. claudia.balotta@unimi.it
- We evaluated the prevalence of both Q151M and 6-bp insert at position 69 of RT region responsible for multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 variants in 177 patients who failed to respond to combination therapy . Patients had received
- Interaction of methadone with didanosine and stavudine.
- Unique Identifier : AIDSLINE MED/20429902
- Rainey PM; Friedland G; McCance-Katz EF; Andrews L; Mitchell SM; Charles C; Jatlow P
- For opiate-dependent injection drug users infected with HIV, methadone therapy may facilitate adherence to complex highly active antiretroviral therapy (HAART) regimens. Current HAART regimens include one or more nucleoside analogues. We investigated the effects of methadone on the pharmacokinetics of the tablet formu
- Prenatal zidovudine use and congenital anomalies in a medicaid population.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):249-56. Unique Identifier : AIDSLINE MED/20429903
- Newschaffer CJ; Cocroft J; Anderson CE; Hauck WW; Turner BJ; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 21205, USA.
- OBJECTIVES: To examine the association of prescribed zidovudine (ZDV) during pregnancy with congenital anomalies in a population-based cohort. METHODS: Medicaid claims were used to assess prescribed ZDV and children s major congenital anomalies in 1932 liveborn deliveries from 1993 to 1996 to HIV-infected women in the
- Lower HIV-2 plasma viral loads may explain differences between the natural histories of HIV-1 and HIV-2 infections.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):257-63. Unique Identifier : AIDSLINE MED/20429904
- Shanmugam V; Switzer WM; Nkengasong JN; Garcia-Lerma G; Green TA; Ekpini E; Sassan-Morokro M; Antunes F; Manshino K; Soriano V; Wiktor SZ; Heneine W; HIV and Retrovirology Branch, Division of HIV/AIDS, STDs, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- To explain the low transmissibility and pathogenicity of HIV-2 infection s plasma viral loads in both HIV-1- and HIV-2-infected persons were compared by using the polymerase chain reaction (PCR)-based Amp-RT assay to measure levels of reverse transcriptase (RT) activity. The study comprised a total of 155 HIV-infected
- HIV-1-Specific CD4 helper function in persons with chronic HIV-1 infection on antiviral drug therapy as measured by ELISPOT after treatment with an inactivated, gp120-depleted HIV-1 in incomplete Freund's adjuvant.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):264-9. Unique Identifier : AIDSLINE MED/20429905
- Moss RB; Webb E; Giermakowska WK; Jensen FC; Savary JR; Wallace MR; Carlo DJ; The Immune Response Corporation, Carlsbad, California 92008, USA.; shotdoc@imnr.com
- OBJECTIVE: We hypothesized that treatment of HIV-1-seropositive study subjects receiving potent antiviral therapy with an HIV-specific immune-based therapy would increase HIV-1-specific T-helper immune function. DESIGN: 10 HIV-1-seropositive study subjects receiving antiretroviral therapy were treated with an inactiva
- Incidence and trends in Kaposi's sarcoma in the era of effective antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):270-4. Unique Identifier : AIDSLINE MED/20429906
- Jones JL; Hanson DL; Dworkin MS; Jaffe HW; Division of HIV/AIDS Prevention Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, National Center; for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, GA 30341-3724, USA.
- OBJECTIVE: To evaluate the impact of antiretroviral and antiherpesvirus therapies on the incidence of KS and assess trends in incidence of Kaposi s sarcoma (KS) in a large multicenter HIV/AIDS surveillance system between 1990 and 1998. METHODS: Incidence was calculated per 100 person-years (py); the effects of therapi
- Factors affecting African-American participation in AIDS research.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):275-84. Unique Identifier : AIDSLINE MED/20429907
- Sengupta S; Strauss RP; DeVellis R; Quinn SC; DeVellis B; Ware WB; Center for AIDS Prevention Studies, University of California, San; Francisco, California 94105, USA. ssengupta@psg.ucsf.edu
- BACKGROUND: Although African Americans are disproportionately affected by the AIDS epidemic, they are underrepresented in AIDS research, particularly in AIDS clinical trials. This study examines a multidimensional construct of distrust and other factors that may affect willingness to participate in AIDS research. METH
- Age-dependent expression of the HIV-1 coreceptor CCR5 on CD4+ lymphocytes in children [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):285-7. Unique Identifier : AIDSLINE MED/20429908
- Auewarakul P; Sangsiriwut K; Pattanapanyasat K; Wasi C; Lee TH
- Preliminary experience of adverse drug reactions, tolerability, and efficacy of a once-daily regimen of antiretroviral combination therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):287-8. Unique Identifier : AIDSLINE MED/20429909
- Hsieh SM; Hung CC; Lu PL; Chen MY; Chang SC
- Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogenous leukemia [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):289-90. Unique Identifier : AIDSLINE MED/20429910
- Schlegel P; Beatty P; Halvorsen R; McCune J
- Microsporidiosis and HIV [letter]
- Unique Identifier : AIDSLINE MED/20429911
- Dascomb K; Frazer T; Clark RA; Kissinger P; Didier E
- Serotype, parental country of birth, and ethnic status in unlinked anonymous neonatal HIV seroprevalence surveys [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):292-4. Unique Identifier : AIDSLINE MED/20429912
- Ades AE; Parker S; Walker J; Weber JN
- Surveillance of antiretroviral prescriptions [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):294. Unique Identifier : AIDSLINE MED/20429913
- Dworkin MS; Wan PC
- [HIV post-exposure prevention. Minutes are important--therefore PEP (postexposure prophylaxis) emergency set]
- MMW Fortschr Med. 2000;142(3 Suppl):10. Unique Identifier : AIDSLINE MED/20352415
- [Preventing AIDS. Cool--the condom campaign]
- MMW Fortschr Med. 2000;142(3 Suppl):11. Unique Identifier : AIDSLINE MED/20352416
- [A child despite HIV? Starting a family is not a taboo any more]
- MMW Fortschr Med. 2000;142(3 Suppl):12-3. Unique Identifier : AIDSLINE MED/20352417
- Paukstadt W
- [Need for review in research and practice. HIV infection in women is increasing]
- MMW Fortschr Med. 2000;142(3 Suppl):14-5. Unique Identifier : AIDSLINE MED/20352418
- [Lipodystrophy syndrome. After 3 years every third patient has lost his fat]
- MMW Fortschr Med. 2000;142(3 Suppl):16-7. Unique Identifier : AIDSLINE MED/20459980
- [Nutritional therapy in HIV infection. Many approaches, meager data]
- MMW Fortschr Med. 2000;142(3 Suppl):17-8. Unique Identifier : AIDSLINE MED/20459981
- Scharmer U
- [Almost 6,000 double-infected patients in Germany. Hepatitis C burden in HIV patients]
- MMW Fortschr Med. 2000;142(3 Suppl):19. Unique Identifier : AIDSLINE MED/20352419
- [Standards, trends and challenges in HIV medicine (editorial)]
- MMW Fortschr Med. 2000;142(3 Suppl):2. Unique Identifier : AIDSLINE MED/20352410
- Paukstadt W
- [Highly active antiretroviral therapy. A simple combination, but high effectiveness]
- MMW Fortschr Med. 2000;142(3 Suppl):20-2. Unique Identifier : AIDSLINE MED/20352420
- [Safety in routine clinical practice. Hypersensitivity can be managed]
- MMW Fortschr Med. 2000;142(3 Suppl):22-3. Unique Identifier : AIDSLINE MED/20352421
- [Discussed with a current case: physician confidentiality issue in conflict]
- MMW Fortschr Med. 2000;142(3 Suppl):24-5. Unique Identifier : AIDSLINE MED/20352422
- Paukstadt W
- [Controlled tapering of medication. What do structured treatment withdrawal achieve?]
- MMW Fortschr Med. 2000;142(3 Suppl):25-6. Unique Identifier : AIDSLINE MED/20352423
- [Daily routine in an HIV specialty practice. Ambulatory patient monitoring (interview by Waldtraut Paukstadt)]
- MMW Fortschr Med. 2000;142(3 Suppl):27. Unique Identifier : AIDSLINE MED/20352424
- Golz J
- [Choice of first-line therapy. It depends on long-term effectiveness]
- MMW Fortschr Med. 2000;142(3 Suppl):28-9. Unique Identifier : AIDSLINE MED/20352425
- [Less is more--what counts is the number of tablets. Looking at antiretroviral substances]
- MMW Fortschr Med. 2000;142(3 Suppl):3-5. Unique Identifier : AIDSLINE MED/20352411
- Paukstadt W
- [Long-term success in routine clinical practice. Effectiveness trial passed]
- MMW Fortschr Med. 2000;142(3 Suppl):30-1. Unique Identifier : AIDSLINE MED/20352426
- [HIV therapy from the viewpoint of the patient. Four out of five suffer with side-effects]
- MMW Fortschr Med. 2000;142(3 Suppl):32-3. Unique Identifier : AIDSLINE MED/20352427
- Wepner U
- [New therapy approaches for HIV infected patients. Hope on the immune front]
- MMW Fortschr Med. 2000;142(3 Suppl):33. Unique Identifier : AIDSLINE MED/20352428
- [Non-nucleoside reverse transcriptase inhibitors. First line therapy]
- MMW Fortschr Med. 2000;142(3 Suppl):34-5. Unique Identifier : AIDSLINE MED/20352429
- [Effectiveness also in general practice conditions. Just as good in routine practice as in studies]
- MMW Fortschr Med. 2000;142(3 Suppl):36-7. Unique Identifier : AIDSLINE MED/20352430
- [Switch strategy: replacing the protease inhibitor. Quality of life improves]
- MMW Fortschr Med. 2000;142(3 Suppl):37. Unique Identifier : AIDSLINE MED/20459982
- [Looking at the HIV test. Qualitative virus detection a cost-effective alternative?]
- MMW Fortschr Med. 2000;142(3 Suppl):38. Unique Identifier : AIDSLINE MED/20352431
- Scharmer U
- [New generation protease inhibitor. Tolerance and potency, a tight association]
- MMW Fortschr Med. 2000;142(3 Suppl):40-1. Unique Identifier : AIDSLINE MED/20352432
- [Ritonavir/Saqinavir: dual protease inhibitor combination. Salvage therapy]
- MMW Fortschr Med. 2000;142(3 Suppl):41. Unique Identifier : AIDSLINE MED/20459983
- [Administer a protease inhibitor immediately? Proceeding strategically in HIV therapy]
- MMW Fortschr Med. 2000;142(3 Suppl):6-7. Unique Identifier : AIDSLINE MED/20352412
- [Holding option open for subsequent treatment. Beginning therapy with a protease inhibitor]
- MMW Fortschr Med. 2000;142(3 Suppl):8-9. Unique Identifier : AIDSLINE MED/20352413
- [Living with HIV therapy. Side effects are the main problem]
- MMW Fortschr Med. 2000;142(3 Suppl):9. Unique Identifier : AIDSLINE MED/20352414
- HTLV-I associated infective dermatitis may be an indolent HTLV-I associated lymphoma.
- Braz J Infect Dis. 2000 Apr;4(2):100-2. Unique Identifier : AIDSLINE MED/20259838
- Goncalves DU; Guedes AC; Carneiro-Proietti AB; Lambertucci JR; Departments of Internal Medicine,Dermatology, Ophthalmology,; Preventive and Social Medicine, Federal University of Minas; Gerais.
- When present for a first time blood donation, a 28-year-old Brazilian white female reported a pruritic eczema of the scalp and retroauricular areas since childhood that had been frequently infected. Her mother had been diagnosed as having HTLV-I-associated myelopathy (HAM), and the patient was found to be a human T-ly
- Changing strategies for treatment of systemic mycoses.
- Braz J Infect Dis. 2000 Apr;4(2):47-54. Unique Identifier : AIDSLINE MED/20464221
- Graybill JR; Department of Medicine, Veterans Administration Hospital, San; Antonio, TX 78284, USA.
- There have been a number of changes in strategies in antifungal therapy in the past few years. AIDS related mycoses have decreased, and the increase of fluconazole resistant Candida albicans may be slowing because fewer severely immune depressed patients require constant fluconazole suppression. Candida species contin
- Infectious and neoplastic disorders of the thyroid in AIDS patients: an autopsy study.
- Braz J Infect Dis. 2000 Apr;4(2):67-75. Unique Identifier : AIDSLINE MED/20259834
- Basilio-De-Oliveira CA; Department of Pathology, Gaffree and Guinle University Hospital,; University of Rio de Janeiro (Uni-Rio), Rio de Janeiro, RJ,; Brazil.
- The course of human immunodeficiency virus infection and the acquired immunodeficiency syndrome can be complicated by a variety of endocrine abnormalities. This article describes the findings of a prospective autopsy study of 100 AIDS patients with thyroids compromised by infectious agents or neoplastic disorders from
- A retrospective bacteriological study of mycobacterial infections in patients with acquired immune deficiency syndrome (AIDS).
- Braz J Infect Dis. 2000 Apr;4(2):86-90. Unique Identifier : AIDSLINE MED/20259836
- de C Ramos M; Jacques De Moraes M; Calusni AL; Roscani GN; Picolli Alves E; Clinical Hospital of the State University of Campinas (UNICAMP),; School of Medical Sciences, Campinas, Sao Paulo, Brazil.
- The main species of mycobacteria isolated in 51 patients with acquired immune deficiency syndrome (AIDS) admitted to the Clinical Hospital of UNICAMP (Teaching Hospital) in 1996, were studied retrospectively by recording the isolation site and signs of pathogenesis. Of these isolates, 31 (55%) were M.tuberculosis and
- Lipodystrophy and altered body shape in HIV: a protease inhibitor side effect? What do you tell your patient?
- Case Manager. 1999 Jan-Feb;10(1):45-7; quiz 49. Unique Identifier : AIDSLINE MED/20456008
- Thorn K; Thorn and Associates, Canoga Park, Calif., USA.
- Contact lens considerations for patients infected with HIV.
- Optometry. 2000 Apr;71(4):249-58. Unique Identifier : AIDSLINE MED/20430624
- Chronister CL; Pennsylvania College of Optometry, Philadelphia, USA.
- BACKGROUND: As an eye care practitioner, one must be aware of the many sequelae of HIV disease and its impact on contact lens patients. With the progressing development of anti-HIV medications, patients infected with HIV are living longer and more productive lives. Thus a greater number of patients infected with HIV m
- Use of computer-assisted rescreening as an ancillary tool to subclassify AGUS cervical smears.
- Diagn Cytopathol. 2000 Sep;23(3):165-70. Unique Identifier : AIDSLINE MED/20403951
- Chhieng DC; Elgert PA; Xiong Y; Cangiarella JF; Cohen JM; Department of Pathology, New York University Medical Center, New; York, USA.
- A substantial percentage of women with a diagnosis of atypical glandular cells of undetermined significance (AGUS) on cervical smears harbor a significant squamous or glandular, preneoplastic or neoplastic lesion on subsequent follow-up. Attempts to subclassify AGUS smears by conventional methods have had mixed result
- Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
- EMBO J. 2000 Aug 1;19(15):3956-67. Unique Identifier : AIDSLINE MED/20380930
- Hrimech M; Yao XJ; Branton PE; Cohen EA; Laboratoire de Retrovirologie Humaine, Departement de; microbiologie et immunologie, Faculte de medecine, Universite; de Montreal, Montreal, Quebec, Canada H3C 3J7.
- The Vpr protein of primate lentiviruses arrests cell cycling at the G(2)/M phase through an inactivation of cyclin B-p34(cdc2) and its upstream regulator cdc25. We provide here biochemical and functional evidence demonstrating that human immunodeficiency virus type 1 (HIV-1) Vpr mediates G(2) arrest by forming a compl
- Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active.
- Eur J Biochem. 2000 Aug;267(15):4740-4. Unique Identifier : AIDSLINE MED/20363704
- Werner S; Wohrl BM; Max-Planck-Institut fur molekulare Physiologie, Abteilung; Physikalische Biochemie, Dortmund, Germany.
- Heterodimeric reverse transcriptase (RT) alphabeta from Rous sarcoma virus (RSV) possesses an asymmetric subunit organization with the polymerase and RNase H active sites localized in the alpha subunit. To determine whether homodimeric RSV RTs alpha (63 kDa) or beta (95 kDa) assume alpha subunit organization similar t
- Divalent metal cation binding properties of human prothymosin alpha.
- Eur J Biochem. 2000 Aug;267(15):4745-52. Unique Identifier : AIDSLINE MED/20363705
- Chichkova NV; Evstafieva AG; Lyakhov IG; Tsvetkov AS; Smirnova TA; Karapetian RN; Karger EM; Vartapetian AB; Belozersky Institute of Physico-Chemical Biology and Center of; Molecular Medicine, Moscow State University, Russia.
- The divalent cation binding properties of human prothymosin alpha, an abundant nuclear protein involved in cell proliferation, were evaluated. By using prothymosin alpha retardation on a weak cation chelating resin charged with various divalent cations, specific binding of Zn2+ ions by prothymosin alpha was observed.
- Simulation of electrostatic effects in Fab-antigen complex formation.
- Eur J Biochem. 2000 Aug;267(15):4861-9. Unique Identifier : AIDSLINE MED/20363718
- Fogolari F; Ugolini R; Molinari H; Viglino P; Esposito G; Dipartimento Scientifico e Tecnologico, Universita di Verona,; Italy. fogolari@sci.univr.it
- A model based on the Poisson-Boltzmann equation has been used to model electrostatics in Anti-p24 (HIV-1) Fab-antigen association. The ionization state at different pH values has been simulated and the results have been used to estimate the stability at different pH values and to generate electrostatic potential maps
- Squamous intraepithelial lesions (SILs) and HPV associated changes in HIV infected women or at risk of HIV. DIANAIDS Cooperative Study Group.
- Eur J Gynaecol Oncol. 2000;21(2):155-9. Unique Identifier : AIDSLINE MED/20300461
- Branca M; Migliore G; Giuliani MLeoncini L; Ippolito G; Cappiello G; Garbuglia AR; Schiesari A; Rezza G; Cytopathology Unit, National Institute of Health, Rome, Italy.
- OBJECTIVES: The study concerns the prevalence of squamous intraepithelial lesions (SILs) and the specific cervical cytopathological features of a group of HIV-positive and a group of HIV-negative women recruited in a multicentric cohort study. The assessment of HPV-DNA genotypes was carried out in both groups. METHOD:
- Colposcopy, cytology and HPV-DNA testing in HIV-positive and HIV-negative women.
- Eur J Gynaecol Oncol. 2000;21(2):168-72. Unique Identifier : AIDSLINE MED/20300464
- Torrisi A; Del Mistro A; Onnis GL; Merlin F; Bertorelle R; Minucci D; Institute of Gynaecology and Obstetrics, University of Padua,; Italy.
- In this study we examined the incidence of colposcopic-colpocytologic findings and analyzed Human Papilloma Virus (HPV)-DNA testing by Polymerase Chain Reaction (PCR) in 104 Human Immunodeficiency Virus (HIV) serous positive women (Group 1) and 218 HIV-negative women (control Groups 2 and 3). The aim of the study was
- The role of gammadelta T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodeficiency virus infection.
- Eur J Immunol. 2000 Aug;30(8):2245-56. Unique Identifier : AIDSLINE MED/20400241
- Lehner T; Mitchell E; Bergmeier L; Singh M; Spallek R; Cranage M; Hall G; Dennis M; Villinger F; Wang Y; Department of Immunobiology, Guy's, King's and St. Thomas'; Hospital Medical School, London, GB. thomas.lehner@kcl.ac.uk
- In view of the role of gammadelta(+) T cells in mucosal protection against infection, the proportion of gamma delta T cells was examined in cells eluted from lymphoid and mucosal tissues of macaques immunized with simian immunodeficiency virus (SIV) gp120 and p27 in alum and challenged with live SIV by the rectal muco
- Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production.
- Unique Identifier : AIDSLINE MED/20400250
- Richards DF; Fernandez M; Caulfield J; Hawrylowicz CM; Department of Respiratory Medicine and Allergy, The Guy's, King's; College and St. Thomas' Hospitals School of Medicine, London, GB.
- Glucocorticoids are highly effective in the treatment of allergy and asthma and inhibit the synthesis of IL-4, IL-5 and IL-13 by disease-promoting CD4(+) Th2 cells. CD8(+) T cells also synthesize these cytokines, and the aim of this study was to investigate how glucocorticoids effect cytokine production by these cells
- Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin.
- Eur J Immunol. 2000 Aug;30(8):2355-61. Unique Identifier : AIDSLINE MED/20400251
- Papadopoulos EJ; Fitzhugh DJ; Tkaczyk C; Gilfillan AM; Sassetti C; Metcalfe DD; Hwang ST; Dermatology Branch, National Cancer Institute, Bethesda, MD; 20892-1908, USA.
- Mast cells (MC) are anatomically located near nerves and blood vessels in skin and the gastrointestinal tract and tend to localize within certain cutaneous tumors such as neurofibromas. However, the molecular mechanisms by which MC home to these sites are not well characterized. Fractalkine (FK) is a membrane-bound CX
- Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming.
- Eur J Immunol. 2000 Aug;30(8):2394-403. Unique Identifier : AIDSLINE MED/20400256
- Gagliardi MC; Sallusto F; Marinaro M; Langenkamp A; Lanzavecchia A; De Magistris MT; Laboratory of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita, Rome, Italy.
- Cholera toxin (CT) is a potent mucosal adjuvant that amplifies B and T cell responses to mucosally co-administered antigens, stimulating predominant Th2-type responses. However, little is known about the mechanism of adjuvanticity of CT and on the influence this toxin may have on Th2 cell development during the primin
- Endoscopic features of smooth muscle tumors in children with AIDS.
- Gastrointest Endosc. 2000 Jul;52(1):91-4. Unique Identifier : AIDSLINE MED/20341268
- Molle ZL; Moallem H; Desai N; Anderson V; Rabinowitz SS; Divisions of Pediatric GI & Nutrition, Allergy and Immunology,; Pediatric Infectious Diseases, and Pathology, SUNY Health Science; Center at Brooklyn, NY, USA.
- BACKGROUND: Smooth muscle tumors are the second most common malignancy encountered in children with acquired immunodeficiency syndrome (AIDS). This study reviewed the incidence and endoscopic appearance of smooth muscle tumors in the gastrointestinal tract of children with AIDS undergoing endoscopy. METHODS: Retrospec
- Isolation and characterization of the human cyclin T1 promoter.
- Gene. 2000 Jul 11;252(1-2):39-49. Unique Identifier : AIDSLINE GENBANK/AF255307
- Liu H; Rice AP; Division of Molecular Virology, Baylor College of Medicine, One; Baylor Plaza, 77030, Houston, TX, USA.
- Cyclin T1 (CycT1) is a regulatory subunit of a general RNA polymerase II (RNAP II) elongation factor termed P-TEFb. The human immunodeficiency virus Tat protein directly associates with CycT1 to utilize CycT1/P-TEFb (also called TAK) for activation of RNAP II elongation of the integrated proviral genome. CycT1 mRNA an
- Genomic organization and characterization of promoter function of the human CDK9 gene.
- Gene. 2000 Jul 11;252(1-2):51-9. Unique Identifier : AIDSLINE GENBANK/AF255306
- Liu H; Rice AP; Division of Molecular Virology, Baylor College of Medicine, One; Baylor Plaza, 77030, Houston, TX, USA.
- CDK9 is the catalytic subunit of a general RNA polymerase II (RNAP II) elongation factor termed p-TEFb which is targeted by the human immunodeficiency virus (HIV) Tat protein to activate elongation of the integrated proviral genome. CDK9 mRNA and protein levels have been observed to be induced in activated peripheral
- Rapid progression of primary vaginal squamous cell carcinoma in a young HIV-infected woman.
- Gynecol Oncol. 2000 Sep;78(3 Pt 1):380-2. Unique Identifier : AIDSLINE MED/20442204
- Lee YC; Holcomb K; Buhl A; Holden J; Abulafia O; Division of Gynecologic Oncology, State University of New York; Health Science Center at Brooklyn, Brooklyn, New York 11203, USA.
- BACKGROUND: The association of human immunodeficiency virus (HIV) infection with rapid progression of cervical and anal squamous cell carcinoma has been clearly established by several studies. Human papilloma virus (HPV) infection of the anogenital tract is believed to be the causative agent of cervical, anal, vaginal
- [Equine Rhodococcus equi pneumonia: first report in Israel and its significance for man]
- Harefuah. 1999 Sep;137(5-6):202-4, 262. Unique Identifier : AIDSLINE MED/20415224
- Steinman A; Sutton GA; Elad D; Koret School of Veterinary Medicine, Hebrew University of; Jerusalem.
- Rhodococcus equi is an important pathogen in young horses. In recent years it has been increasingly recognized as an opportunistic infectious agent in patients with immune deficiency. The increase in recognized cases may be related to the increased prevalence of AIDS. However, more cases may have been recognized latel
- Effects of case management and new drugs on Medicaid AIDS spending.
- Health Aff (Millwood). 2000 Jul-Aug;19(4):233-43. Unique Identifier : AIDSLINE MED/20373691
- Mitchell JM; Anderson KH; Georgetown University Public Policy Institute in Washington,; D.C., USA.
- This study evaluates the effects of Florida s participation in the Medicaid acquired immunodeficiency syndrome (AIDS) home and community-based waiver and the use of recently developed AIDS drugs on spending per Medicaid beneficiary. We find that monthly Medicaid spending for waiver non-participants was significantly h
- Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: decreased risk for Hp0 individuals.
- Hum Hered. 2000 Nov-Dec;50(6):382-3. Unique Identifier : AIDSLINE MED/20359324
- Quaye IK; Ekuban FA; Brandful JA; Gyan BA; Akanmori BD; Ankrah NA; Noguchi Memorial Institute for Medical Research University of; Ghana, Legon, Accra, Ghana. noguchi@ncs.com.gh
- Plasma haptoglobin phenotypes were determined by polyacrylamide gel electrophoresis, followed by benzidine staining for 58 HIV-1 seropositive Ghanaians and 79 randomly selected age-matched controls. Hp0 was present in only 14% of HIV-1 seropositive individuals compared with more than 40% of the controls. The Hp0 indiv
- HTLV-I infection among Nivkhi people in Sakhalin: comparative serologic and phylogenetic analyses for 9 years.
- Int J Cancer. 2000 Aug 1;87(3):379-81. Unique Identifier : AIDSLINE MED/20357201
- Syrtsev AV; Yamashita M; Senyuta NB; Susova OY; Hayami M; Gurtsevitch VE; Laboratory of Viral Carcinogenesis, Institute of Carcinogenesis,; N.N. Blokhin Cancer Research Center, Moscow, Russia.
- Evaluation of CD8(+) T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with tyrosinase peptide.
- Int J Cancer. 2000 Aug 1;87(3):391-8. Unique Identifier : AIDSLINE MED/20357203
- Lewis JJ; Janetzki S; Schaed S; Panageas KS; Wang S; Williams L; Meyers M; Butterworth L; Livingston PO; Chapman PB; Houghton AN; Swim Across America Laboratory, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021, USA. lewisj@mskcc.org
- The lack of reproducible, quantitative assays for T-cell responses has been a limitation in the development of cancer vaccines to elicit T-cell immunity. We utilized the Elispot assay, which allows a quantitative and functional assessment of T cells directed against specific peptides after only brief in vitro incubati
- An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells.
- Int J Cancer. 2000 Oct 1;88(1):115-20. Unique Identifier : AIDSLINE MED/20419975
- Hombach A; Schneider C; Sent D; Koch D; Willemsen RA; Diehl V; Kruis W; Bolhuis RL; Pohl C; Abken H; Klinik I fur Innere Medizin, Labor Tumorgenetik, Universitat zu; Koln, Koln, Germany.
- Recombinant T-cell receptors with antibody-like specificity for tumor-associated antigens are successfully used to direct the cytolytic activity of T cells toward tumor cells. Clinical application, however, needs to comply with the low immunogenicity of the recombinant receptor, efficient gene transfer into peripheral
- Women, drugs and HIV/AIDS: results of a multicentre European study.
- Int J Epidemiol. 2000 Aug;29(4):734-43. Unique Identifier : AIDSLINE MED/20382770
- Estebanez PE; Russell NK; Aguilar MD; Beland F; Zunzunegui MV; Departamento de Salud Publica, Universidad Miguel Hernandez,; San Juan de Alicante, Spain. mdm.sec-admin@apdo.com
- BACKGROUND: In the light of rising human immunodeficiency virus (HIV) incidence rates amongst women in Western Europe, a multicentred, cross-sectional study was undertaken to explore the multitude of possible factors associated with HIV in a population of female injecting drug users (IDU). METHODS: Face-to-face interv
- Editorial commentary regarding prevention of blood borne diseases in the health care setting (Sep/Oct '99) [letter]
- Ir Med J. 1999 Nov-Dec;92(7):440. Unique Identifier : AIDSLINE MED/20423581
- Molloy C
- A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
- J Biol Chem. 2000 Aug 25;275(34):25985-92. Unique Identifier : AIDSLINE MED/20408936
- Sabroe I; Peck MJ; Van Keulen BJ; Jorritsma A; Simmons G; Clapham PR; Williams TJ; Pease JE; Leukocyte Biology Section, Biomedical Sciences Division, Sir; Alexander Fleming Building, Imperial College School of Medicine,; South Kensington, London SW7 2AZ, United Kingdom.
- We describe a small molecule chemokine receptor antagonist, UCB35625 (the trans-isomer J113863 published by Banyu Pharmaceutical Co., patent WO98/04554), which is a potent, selective inhibitor of CCR1 and CCR3. Nanomolar concentrations of UCB35625 were sufficient to inhibit eosinophil shape change responses to MIP-1al
- Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.
- J Biol Chem. 2000 Aug 25;275(34):26309-15. Unique Identifier : AIDSLINE MED/20408979
- Rosenkilde MM; Kledal TN; Holst PJ; Schwartz TW; Laboratory for Molecular Pharmacology, Department of; Pharmacology, The Panum Institute, University of Copenhagen,; DK-2200 Copenhagen, Denmark.
- Open reading frame 74 (ORF74) encoded by human herpesvirus 8 is a highly constitutively active seven transmembrane (7TM) receptor stimulated by angiogenic chemokines, e.g. growth-related oncogene-alpha, and inhibited by angiostatic chemokines e.g. interferon-gamma-inducible protein. Transgenic mice expressing ORF74 un
- Targeted drug delivery to C6 glioma by transferrin-coupled liposomes.
- J Biomed Mater Res. 2000 Jul;51(1):10-4. Unique Identifier : AIDSLINE MED/20273883
- Eavarone DA; Yu X; Bellamkonda RV; Biomaterials, Cell and Tissue Engineering Laboratory, Department; of Biomedical Engineering, Case Western Reserve University, 10900; Euclid Avenue, Cleveland, Ohio 44106, USA.
- Recent advances in liposome technology have shown promise relative to the introduction of chemotherapeutic agents with reduced toxicity, extended longevity, and potential for cell-specific targeting. In this study we report the engineering of a liposomal delivery system for the chemotherapeutic drug doxorubicin. The s
- HTLV-1 infections.
- Unique Identifier : AIDSLINE MED/20457860
- Bangham CR
- Human T lymphotropic virus type 1 (HTLV-1) causes disabling and fatal diseases, yet there is no vaccine, no satisfactory treatment, and no means of assessing the risk of disease or
- Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7.
- J Clin Pathol. 2000 Aug;53(8):612-4. Unique Identifier : AIDSLINE MED/20457866
- Mattes FM; McLaughlin JE; Emery VC; Clark DA; Griffiths PD; Department of Virology, Royal Free and University College Medical; School, London, UK. mattes@rfhsm.ac.uk
- BACKGROUND: Cytomegalovirus ( CMV ) is the prototype member of the beta-herpesvirinae, which can cause multiple organ dysfunction in the immunocompromised host. Human herpesvirus 6 (HHV-6) and HHV-7 are newer members of the beta-herpesvirinae that can cause febril
- Some problems found in HIV-1 RNA quantification [letter]
- J Clin Pathol. 2000 Aug;53(8):645-6. Unique Identifier : AIDSLINE MED/20457879
- Yoshida S; Yusa N; Sato N; Goto M; Iwamoto A
- The senescence-accelerated mouse shows aging-related defects in cellular but not humoral immunity against influenza virus infection.
- J Infect Dis. 2000 Aug;182(2):391-6. Unique Identifier : AIDSLINE MED/20375027
- Dong L; Mori I; Hossain MJ; Kimura Y; Department of Microbiology, Fukui Medical University School of; Medicine, Fukui, Japan.
- The senescence-accelerated mouse (SAM) strain P1, which has a short life span, was adopted as a murine model for an investigation of the pathogenesis of viral infection in elderly adults. After intranasal inoculation with influenza A virus, the SAM-P1 mice showed a higher rate of mortality, with prolonged virus growth
- Detection of a major gene predisposing to human T lymphotropic virus type I infection in children among an endemic population of African origin.
- J Infect Dis. 2000 Aug;182(2):405-12. Unique Identifier : AIDSLINE MED/20375029
- Plancoulaine S; Gessain A; Joubert M; Tortevoye P; Jeanne I; Talarmin A; de The G; Abel L; INSERM U436, "Modelisation Mathematique et Statistique en; Biologie et Medecine," CHU Pitie Salpetriere, Unite; d'Epidemiologie des Virus Oncogenes, Institut Pasteur, Paris,; France.
- Human T lymphotropic virus type I (HTLV-I) is a human oncoretrovirus that causes an adult T cell leukemia/lymphoma and a chronic neuromyelopathy. To investigate whether familial aggregation of HTLV-I infection (as determined by specific seropositive status) could be explained in part by genetic factors, we conducted a
- The CCR5Delta32 allele slows disease progression of human immunodeficiency virus-1-infected children receiving antiretroviral treatment.
- J Infect Dis. 2000 Aug;182(2):413-9. Unique Identifier : AIDSLINE MED/20375030
- Barroga CF; Raskino C; Fangon MC; Palumbo PE; Baker CJ; Englund JA; Spector SA; Department of Pediatrics, University of California San Diego, La; Jolla, CA 92093-0672, USA.
- The role of the CCR5Delta32 allele in human immunodeficiency virus (HIV)-1-related disease progression was analyzed for 457 antiretroviral-naive children who had participated in the Pediatric AIDS Clinical Trials Group 152 study, which demonstrated that didanosine (ddI) or zidovudine + ddI treatments were superior to
- Correlation between human immunodeficiency virus genotypic resistance and virologic response in patients receiving nelfinavir monotherapy or nelfinavir with lamivudine and zidovudine.
- J Infect Dis. 2000 Aug;182(2):420-7. Unique Identifier : AIDSLINE MED/20375031
- Atkinson B; Isaacson J; Knowles M; Mazabel E; Patick AK; Agouron Pharmaceuticals, Inc., San Diego, California, 92121, USA.
- The relationship between detectable human immunodeficiency virus (HIV) genotypic resistance and virologic response was compared in patients receiving nelfinavir as monotherapy (16 weeks) or in combination with lamuvidine and zidovudine (48 weeks). Two patient groups were defined on the basis of the presence or absence
- Pooled analysis of 3 randomized, controlled trials of interleukin-2 therapy in adult human immunodeficiency virus type 1 disease.
- J Infect Dis. 2000 Aug;182(2):428-34. Unique Identifier : AIDSLINE MED/20375032
- Emery S; Capra WB; Cooper DA; Mitsuyasu RT; Kovacs JA; Vig P; Smolskis M; Saravolatz LD; Lane HC; Fyfe GA; Curtin PT; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW 2010, Australia. semery@nchecr.unsw.edu.au.
- We collected human immunodeficiency virus (HIV) disease progression, survival, most recent CD4 cell count, and plasma HIV RNA levels from patients (n=157) who participated in randomized clinical trials of interleukin (IL)-2 that commenced before 1995. Data were available for 155 (99%) patients. Statistical analyses we
- Evaluation of CD4+ T cell function In vivo in HIV-infected patients as measured by bacteriophage phiX174 immunization.
- J Infect Dis. 2000 Aug;182(2):435-41. Unique Identifier : AIDSLINE MED/20375033
- Fogelman I; Davey V; Ochs HD; Elashoff M; Feinberg MB; Mican J; Siegel JP; Sneller M; Lane3 HC; Biologic Consulting, Inc., Edgewater, MD 21037, USA.; ilanafog@aol. com
- Bacteriophage phiX174 immunization was used to measure CD4(+) T cell function in vivo in human immunodeficiency virus (HIV)-infected patients across all disease stages. Function was evaluated by measuring the ability of T cells to provide help to B cells in antibody production, amplification, and isotype switching. A
- Human immunodeficiency virus type 1 subtype E envelope recombinant peptides containing naturally immunogenic epitopes.
- J Infect Dis. 2000 Aug;182(2):442-50. Unique Identifier : AIDSLINE MED/20375034
- Chang SY; Vithayasai V; Vithayasai P; Essex M; Lee TH; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115, USA.
- A series of recombinant peptides of the human immunodeficiency virus type 1 (HIV-1) subtype E envelope were used to address the question of whether immunogenic epitopes similar to those described for the subtype B envelope are also present in structurally analogous regions of another HIV-1 subtype with divergent seque
- Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans.
- J Infect Dis. 2000 Aug;182(2):451-8. Unique Identifier : AIDSLINE MED/20375035
- Roos MT; van Lier RA; Hamann D; Knol GJ; Verhoofstad I; van Baarle D; Miedema F; Schellekens PT; Department of Clinical Viro-Immunology, CLB and Laboratory for; Experimental and Clinical Immunology of the University of; Amsterdam at the CLB, Amsterdam, The Netherlands. m_roos@clb.nl
- In response to viral infection, unprimed naive CD8(+), major histocompatibility complex class I-restricted, virus-specific T cells clonally expand and differentiate into memory- and effector-type cells. Changes in CD8(+) subset distribution were studied in 17 subjects with acute human immunodeficiency virus type 1 inf
- Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts.
- J Infect Dis. 2000 Aug;182(2):459-66. Unique Identifier : AIDSLINE MED/20375036
- Anzala AO; Simonsen JN; Kimani J; Ball TB; Nagelkerke NJ; Rutherford J; Ngugi EN; Bwayo JJ; Plummer FA; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.
- In Kenya , the median incubation time to AIDS in seroconverting sex workers is 4 years; this incubation time is specific to female sex workers. We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency viru
- High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus.
- J Infect Dis. 2000 Aug;182(2):467-73. Unique Identifier : AIDSLINE MED/20375037
- Sturm-Ramirez K; Gaye-Diallo A; Eisen G; Mboup S; Kanki PJ; Department of Immunology and Infectious Diseases, Harvard School; of Public Health and Harvard AIDS Institute, Boston,; Massachusetts 02115, USA.
- Bacterial vaginosis (BV) was identified recently as a cofactor that promotes sexual transmission of human immunodeficiency virus (HIV). This study was done to determine if interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha could be measured consistently in cervical secretions and if high levels of these cyto
- Natural T, gammadelta, and NK cells in mycobacterial, Salmonella, and human immunodeficiency virus infections.
- J Infect Dis. 2000 Aug;182(2):474-81. Unique Identifier : AIDSLINE MED/20375038
- Jason J; Buchanan I; Archibald LK; Nwanyanwu OC; Bell M; Green TA; Eick A; Han A; Razsi D; Kazembe PN; Dobbie H; Midathada M; Jarvis WR; Immunology Branch, Division of AIDS, STD, and TB Laboratory; Research, National Center for Infectious Diseases, Atlanta, GA; 30333. JMJ1@CDC.gov.
- NK cells, gammadelta T cell antigen receptor chain-positive cells, and CD3(+)CD16/56(+) (natural T [NT]) cells are involved in innate immunity and immunoregulation; however, their role in clinical infection is not well defined. Cytofluorometric analysis was used to examine peripheral blood from bacteremic, nonbacterem
- Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients.
- J Infect Dis. 2000 Aug;182(2):551-7. Unique Identifier : AIDSLINE MED/20375048
- Kazanjian P; Armstrong W; Hossler PA; Burman W; Richardson J; Lee CH; Crane L; Katz J; Meshnick SR; Division of Infectious Diseases, Dept. of Medicine, University of; Michigan Health System, Ann Arbor, MI 48109-0378, USA.; pkazanji@umich.edu
- This study was conducted to determine whether Pneumocystis carinii dyhydropteroate synthase (DHPS) gene mutations in AIDS patients with P. carinii pneumonia (PCP) are affected by duration of sulfa or sulfone prophylaxis and influence response to sulfa or sulfone therapy. The P. carinii DHPS genes from 97 AIDS patients
- Biological considerations in the development of a human immunodeficiency virus vaccine.
- J Infect Dis. 2000 Aug;182(2):579-89. Unique Identifier : AIDSLINE MED/20375052
- Nathanson N; Mathieson BJ; Office of AIDS Research, National Institutes of Health, Bethesda,; MD 20892-2340, USA. nathansn@od.nih.gov
- Over the last 12 years, many human immunodeficiency virus (HIV) vaccine candidates have been tried in humans, with disappointing results. In particular, recombinant envelope proteins have failed to elicit strong cellular immune responses or neutralizing antibody against many wild-type isolates of HIV-1. Attenuated str
- Increased liver decompensation risk with atypical hepatitis C virus antibody levels.
- J Infect Dis. 2000 Aug;182(2):590-4. Unique Identifier : AIDSLINE MED/20375053
- Goedert JJ; Hatzakis A; Maloney EM; Eyster ME; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852, USA. goedertJ@mail.nih.gov
- Knowledge of serum markers of liver decompensation would facilitate care of patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. HCV load and anti-c33c and anti-NS5 levels did not distinguish 28 HCV- and HIV-positive predecompensation patients from 28 matched control patients, where
- Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients.
- J Infect Dis. 2000 Aug;182(2):599-602. Unique Identifier : AIDSLINE MED/20375055
- Molina JM; Ferchal F; Rancinan C; Raffi F; Rozenbaum W; Sereni D; Morlat P; Journot V; Decazes JM; Chene G; Clinique des Maladies Infectieuses, Hopital Saint-Louis, 1; Avenue Claude Vellefaux, 75475 Paris Cedex 10, France.; molina@chu-stlouis.fr
- The safety and efficacy of a once-daily regimen that combines emtricitabine, didanosine, and efavirenz was studied among 40 previously untreated human immunodeficiency virus (HIV)-infected patients. The median plasma HIV RNA level was 4.77 log(10) copo
- Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease.
- J Infect Dis. 2000 Aug;182(2):603-6. Unique Identifier : AIDSLINE MED/20375056
- Kalish LA; Collier AC; Flanigan TP; Kumar PN; New England Research Institutes, Watertown, MA 02472, USA.; lesk@neri.org
- Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study oo
- A fusion inhibitor (FP-21399) for the treatment of human immunodeficiency virus infection: a phase I study.
- J Infect Dis. 2000 Aug;182(2):607-10. Unique Identifier : AIDSLINE MED/20375057
- Dezube BJ; Dahl TA; Wong TK; Chapman B; Ono M; Yamaguchi N; Gillies SD; Chen LB; Crumpacker CS; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Boston, MA 02215, USA. bdezube@caregroup.harvard.edu
- FP-21399 is a bis(disulfonaphthalene) derivative that prevents human immunodeficiency virus (HIV) infection of uninfected cells by blocking entry of the virus. FP-21399 shows an affinity for lymph nodes. In this phase I study, FP-21399 was administered intravenously over 1 h as a single dose (0.9, 1.7, 2.8, and 4.2 mgo
- Risk for preventable opportunistic infections in persons with AIDS after antiretroviral therapy increases CD4+ T lymphocyte counts above prophylaxis thresholds.
- J Infect Dis. 2000 Aug;182(2):611-5. Unique Identifier : AIDSLINE MED/20375058
- Dworkin MS; Hanson DL; Kaplan JE; Jones JL; Ward JW; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA. mdd3@cdc.gov
- To determine incidence and risk for preventable opportunistic infections (Pneumocystis carinii pneumonia [PCP] and disseminated Mycobacterium avium-complex [MAC] infection) in persons whose CD4(+) T lymphocyte counts had increased by >/=100 cells/&mgr;L to exceed the threshold of risk and in persons whose CD4(+) co
- Tumor necrosis factor-alpha increased production during thalidomide treatment in patients with tuberculosis and human immunodeficiency virus coinfection [letter]
- J Infect Dis. 2000 Aug;182(2):639-40. Unique Identifier : AIDSLINE MED/20375064
- Gori A; Rossi MC; Trabattoni D; Marchetti G; Fusi ML; Molteni C; Clerici M; Franzetti1 F
- B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells.
- J Exp Med. 2000 Sep 4;192(5):637-46. Unique Identifier : AIDSLINE MED/20432252
- Moir S; Malaspina A; Li Y; Chun TW; Lowe T; Adelsberger J; Baseler M; Ehler LA; Liu S; Davey RT Jr; Mican JA; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. smoir@niaid.nih.gov
- The impact of HIV-associated immunopathogenesis on B cells has been largely associated with indirect consequences of viral replication. This study demonstrates that HIV interacts directly with B cells in both lymphoid tissues and peripheral blood. B cells isolated from lymph node and peripheral blood mononuclear cells
- [Infected aneurysm of abdominal aorta: early CT finding]
- J Radiol. 2000 Aug;81(8):899-901. Unique Identifier : AIDSLINE MED/20377703
- Sellami D; Lucidarme O; Lebleu L; Grenier P; Service de radiologie, Universite Pierre-et-Marie-Curie,; Hopital de la Pitie-Salpeltriere, 47, boulevard de; l'Hopital, 75651 Paris Cedex 13.
- Infected abdominal aortic aneurysm is an uncommon but life-threatening disease, especially in case of salmonella infection. Early CT findings should be well known in order to allow immediate diagnosis and accurate management. The authors present an early CT finding of a salmonella infected aneurysm of abdominal aorta
- How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.
- J Mol Biol. 2000 Sep 1;301(5):1207-20. Unique Identifier : AIDSLINE PDB/1F7A
- Prabu-Jeyabalan M; Nalivaika E; Schiffer CA; Department of Pharmacology and Molecular Toxicology, University; of Massachusetts Medical School, Worcester, MA, 01655, USA.
- The crystal structure of an actual HIV-1 protease-substrate complex is presented at 2.0 A resolution (R-value of 19.7 % (R(free) 23.3 %)) between an inactive variant (D25N) of HIV-1 protease and a long substrate peptide, Lys-Ala-Arg-Val-Leu-Ala-Glu-Ala-Met-Ser, which covers a full binding epitope of capsid(CA)-p2, cle
- Burnout in substance abuse counselors. Impact of environment, attitudes, and clients with HIV.
- J Subst Abuse Treat. 2000 Sep;19(2):117-26. Unique Identifier : AIDSLINE MED/20420124
- Shoptaw S; Stein JA; Rawson RA; Matrix Center, 12304 Santa Monica Boulevard, Suite, 90025, Los; Angeles, CA, USA. shoptaw@ix.netcom.com
- Due to associations between acquired immunodeficiency sydnrome (AIDS) and substance abuse, many substance abuse treatment counselors have clients with human immunodeficiency virus (HIV)/AIDS. We assess the contribution of various hypothesized predictors of burnout among 134 substance abuse counselors working with clie
- Effect of the cytoplasmic domain of the simian immunodeficiency virus envelope protein on incorporation of heterologous envelope proteins and sensitivity to neutralization.
- J Virol. 2000 Sep;74(18):8219-25. Unique Identifier : AIDSLINE MED/20411391
- Vzorov AN; Compans RW; Department of Microbiology and Immunology and Emory Vaccine; Center, Emory University School of Medicine, Atlanta, Georgia; 30322, USA.
- In addition to the viral envelope (Env) proteins, host cell-derived proteins have been reported to be present in human immunodeficiency virus and simian immunodeficiency virus (SIV) envelopes, and it has been postulated that they may play a role in infection. We investigated whether the incorporation of host cell prot
- Expression of mouse mammary tumor virus superantigen accelerates tumorigenicity of myeloma cells.
- J Virol. 2000 Sep;74(18):8226-33. Unique Identifier : AIDSLINE MED/20411392
- Umemura M; Wajjwalku W; Upragarin N; Liu T; Nishimura H; Matsuguchi T; Nishiyama Y; Wilson GM; Yoshikai Y; Laboratory of Host Defense, Research Institute for Disease; Mechanism and Control, Nagoya University School of Medicine,; Nagoya 466-8550, Japan.
- To investigate whether superantigen (SAG) from endogenous mouse mammary tumor virus functions as an immunogenic or a tumorigenic factor in tumor development, the BALB/c myeloma cell line FO was transfected with the SAG gene from the 3 Mtv-50 long terminal repeat (LTR) open reading frame (ORF), the product of which wa
- Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process.
- J Virol. 2000 Sep;74(18):8252-61. Unique Identifier : AIDSLINE MED/20411395
- Zhang H; Pomerantz RJ; Dornadula G; Sun Y; Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA. hui.zhang@mail.tju.edu
- Virion infectivity factor (Vif) is a protein encoded by human immunodeficiency virus types 1 and 2 (HIV-1 and -2) and simian immunodeficiency virus, plus other lentiviruses, and is essential for viral replication either in vivo or in culture for nonpermissive cells such as peripheral blood lymphoid cells, macrophages,
- In vivo genomic footprinting of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat enhancer sequences in HTLV-1-infected human T-cell lines with different levels of Tax I activity.
- J Virol. 2000 Sep;74(18):8277-85. Unique Identifier : AIDSLINE MED/20411398
- Datta S; Kothari NH; Fan H; Cancer Research Institute and Department of Molecular Biology and; Biochemistry, University of California, Irvine, California 92697,; USA.
- The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) enhances viral gene expression through sequences in the U3 region of the viral long terminal repeat. These sequences consist of three imperfect 21-bp repeats (TRE-1s) and a region between the promoter-central and promoter-proximal 21-bp repeats (TRE-2). Th
- Direct ex vivo kinetic and phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization.
- J Virol. 2000 Sep;74(18):8286-91. Unique Identifier : AIDSLINE MED/20411399
- Hassett DE; Slifka MK; Zhang J; Whitton JL; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA. dhassett@scripps.edu
- CD8(+) T-cell responses can be induced by DNA immunization, but little is known about the kinetics of these responses in vivo in the absence of restimulation or how soon protective immunity is conferred by a DNA vaccine. It is also unclear if CD8(+) T cells primed by DNA vaccines express the vigorous effector function
- Avian retrovirus DNA internal attachment site requirements for full-site integration in vitro.
- J Virol. 2000 Sep;74(18):8292-8. Unique Identifier : AIDSLINE MED/20411400
- Chiu R; Grandgenett DP; Institute for Molecular Virology, St. Louis University Health; Sciences Center, St. Louis, Missouri 63110, USA.
- Concerted integration of retrovirus DNA termini into the host chromosome in vivo requires specific interactions between the cis-acting attachment (att) sites at the viral termini and the viral integrase (IN) in trans. In this study, reconstruction experiments with purified avian myeloblastosis virus (AMV) IN and retro
- gammadelta(+) T-Lp6phocyte cytotoxicity against envelope-expressing target cells is unique to the alymphocytic state of bovine leukemia virus infection in the natural host.
- J Virol. 2000 Sep;74(18):8299-306. Unique Identifier : AIDSLINE MED/20411401
- Lundberg P; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
- Bovine leukemia virus (BLV) is a complex B-lymphotrophic retrovirus of cattle and the causative agent of enzootic bovine leukosis. Serum antibody in infected animals does not correlate with protection from disease, yet only some animals develop severe disease. While a cytotoxic T-lymphocyte response may be responsible
- Development of minimal lentivirus vectors derived from simian immunodeficiency virus (SIVmac251) and their use for gene transfer into human dendritic cells.
- J Virol. 2000 Sep;74(18):8307-15. Unique Identifier : AIDSLINE MED/20411402
- Mangeot PE; Negre D; Dubois B; Winter AJ; Leissner P; Mehtali M; Kaiserlian D; Cosset FL; Darlix JL; LaboRetro, Unite de Virologie Humaine (INSERM-ENS no. 412),; Lyon, France.
- Lentivirus-derived vectors are very promising gene delivery systems since they are able to transduce nonproliferating differentiated cells, while murine leukemia virus-based vectors can only transduce cycling cells. Here we report the construction and characterization of highly efficient minimal vectors derived from s
- Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity.
- Unique Identifier : AIDSLINE MED/20411403
- Sierra S; Davila M; Lowenstein PR; Domingo E
- Passage of foot-and-mouth disease virus (FMDV) in cell culture in the presence of the mutagenic base analog 5-fluorouracil or 5-azacytidine resulted in decreases of infectivity and occasional extinction of the virus. Low viral loads and low viral fitness
- Sequences in the 5' and 3' R elements of human immunodeficiency virus type 1 critical for efficient reverse transcription.
- J Virol. 2000 Sep;74(18):8324-34. Unique Identifier : AIDSLINE MED/20411404
- Ohi Y; Clever JL; Department of Microbiology, University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78229-3900, USA.
- The genome of human immunodeficiency virus type 1 (HIV-1) contains two direct repeats (R) of 97 nucleotides at each end. These elements are of critical importance during the first-strand transfer of reverse transcription, during which the minus-strand strong-stop DNA (-sssDNA) is transferred from the 5 end to the 3
- CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.
- J Virol. 2000 Sep;74(18):8349-57. Unique Identifier : AIDSLINE MED/20411407
- Neville KL; Dal Canto MC; Bluestone JA; Miller SD; Department of Microbiology-Immunology, Interdepartmental; Immunobiology Center, Northwestern University Medical School,; Chicago, Illinois 60611, USA.
- Theiler s murine encephalomyelitis virus (TMEV) is a natural mouse pathogen which causes a lifelong persistent infection of the central nervous system (CNS) accompanied by T-cell-mediated myelin destruction leading to chronic, progressive hind limb paralysis. TMEV-induced demyelinating disease (TMEV-IDD) is considered
- Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120.
- J Virol. 2000 Sep;74(18):8358-67. Unique Identifier : AIDSLINE MED/20411408
- Derdeyn CA; Decker JM; Sfakianos JN; Wu X; O'Brien WA; Ratner L; Kappes JC; Shaw GM; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.
- T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion active state following interactions of the surface glycoprotein, gp120, with CD4 and coreceptor molecules displayed on the target cell
- Specific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection.
- J Virol. 2000 Sep;74(18):8376-81. Unique Identifier : AIDSLINE MED/20411410
- Lidbury BA; Mahalingam S; Gadi Research Centre, Division of Science and Design, University; of Canberra, Canberra, ACT 2601, Australia.; Lidbury@scides.canberra.edu.au
- Ross River virus (RRV) is an indigenous Australian arthropod-borne alphavirus responsible for epidemic polyarthritis (EPA), myalgia, and lethargy in humans. Macrophages and monocytes have been associated with human RRV disease, and previous studies have shown that RRV is capable of infecting macrophages via both a nat
- Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.
- J Virol. 2000 Sep;74(18):8390-401. Unique Identifier : AIDSLINE MED/20411412
- Archer RH; Dykes C; Gerondelis P; Lloyd A; Fay P; Reichman RC; Bambara RA; Demeter LM; Department of Medicine, University of Rochester School of; Medicine and Dentistry, Rochester, New York 14642, USA.
- Three mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (V106A, V179D, and Y181C), which occur in clinical isolates and confer resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs), were analyzed for RNA- and DNA-dependent DNA polymerization and RNase H cleavage. All mutants
- Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.
- J Virol. 2000 Sep;74(18):8413-24. Unique Identifier : AIDSLINE MED/20411414
- Kaur A; Hale CL; Ramanujan S; Jain RK; Johnson RP; Division of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, Massachusetts; 01772, USA. amitinder_kaur@hms.harvard.edu
- Although lymphocyte turnover in chronic human immunodeficiency virus and simian immunodeficiency virus (SIV) infection has been extensively studied, there is little information on turnover in acute infection. We carried out a prospective kinetic analysis of lymphocyte proliferation in 13 rhesus macaques inoculated wit
- Analysis of Mason-Pfizer monkey virus Gag domains required for capsid assembly in bacteria: role of the N-terminal proline residue of CA in directing particle shape.
- J Virol. 2000 Sep;74(18):8452-9. Unique Identifier : AIDSLINE MED/20411418
- Rumlova-Klikova M; Hunter E; Nermut MV; Pichova I; Ruml T; Department of Biochemistry, Institute of Organic Chemistry and; Biochemistry, Academy of Sciences, 166 10 Prague, Czech Republic.
- Mason- Pfizer monkey virus (M-PMV) preassembles immature capsids in the cytoplasm prior to transporting them to the plasma membrane. Expression of the M-PMV Gag precursor in bacteria results in the assembly of capsids indistinguishable from those assembled in mammalian cell
- Efficient cell infection by Moloney murine leukemia virus-derived particles requires minimal amounts of envelope glycoprotein.
- J Virol. 2000 Sep;74(18):8480-6. Unique Identifier : AIDSLINE MED/20411421
- Bachrach E; Marin M; Pelegrin M; Karavanas G; Piechaczyk M; Institut de Genetique Moleculaire, UMR 5535/IFR24, CNRS, BP; 5051, 34293 Montpellier Cedex 05, France.
- Retrovirus entry into cells is mediated by specific interactions between the retrovirally encoded Env envelope glycoprotein and a host cell surface receptor. Though a number of peptide motifs responsible for the structure as well as for the binding and fusion activities of Env have been identified, only a few quantita
- Patterns of changes in human immunodeficiency virus type 1 V3 sequence populations late in infection.
- J Virol. 2000 Sep;74(18):8494-501. Unique Identifier : AIDSLINE GENBANK/AF155906
- Nelson JA; Baribaud F; Edwards T; Swanstrom R; UNC Center for AIDS Research, University of North Carolina at; Chapel Hill, Chapel Hill, North Carolina 27599, USA.
- We have used a V3-specific heteroduplex tracking assay (V3-HTA) with probes from two different human immunodeficiency virus type 1 (HIV-1) subtypes to examine the extent and pace of HIV-1 evolution late in infection. Twenty-four subjects with advanced HIV-1 infection (CD4(+) T-cell count,
- Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug.
- J Virol. 2000 Sep;74(18):8524-31. Unique Identifier : AIDSLINE MED/20411426
- Mammano F; Trouplin V; Zennou V; Clavel F; Laboratoire de Recherche Antivirale, INSERM U82, Paris, France.; mammano@bichat.inserm.fr
- Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) is a major obstacle to the full success of combined antiretroviral therapy. High-level resistance to these compounds is the consequence of stepwise accumulation of amino acid substitu
- Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.
- J Virol. 2000 Sep;74(18):8532-40. Unique Identifier : AIDSLINE MED/20411427
- Schwam DR; Luciano RL; Mahajan SS; Wong L; Wilson AC; Department of Microbiology and Kaplan Comprehensive Cancer; Center, New York University School of Medicine, New York, New; York 10016, USA.
- Human herpesvirus 8 (HHV-8; also known as Kaposi s sarcoma-associated herpesvirus) is the causative agent of Kaposi s sarcoma and certain B-cell lymphomas. In most infected cells, HHV-8 establishes a latent infection characterized by the expression of latency-associated nuclear antigen (LANA) encoded by open reading f
- Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
- J Virol. 2000 Sep;74(18):8541-9. Unique Identifier : AIDSLINE MED/20411428
- Altfeld MA; Trocha A; Eldridge RL; Rosenberg ES; Phillips MN; Addo MM; Sekaly RP; Kalams SA; Burchett SA; McIntosh K; Walker BD; Goulder PJ; Partners AIDS Research Center and Infectious Disease Unit,; Massachusetts General Hospital and Harvard Medical School,; Boston, USA.
- Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte (CTL) responses play a major role in the antiviral immune response, but the relative contribution of CTL responses restricted by different HLA class I molecules is less well defined. HLA-B60 or the related allele B61 is expressed in 10 to 20%
- CD4-Negative cells bind human immunodeficiency virus type 1 and efficiently transfer virus to T cells.
- J Virol. 2000 Sep;74(18):8550-7. Unique Identifier : AIDSLINE MED/20411429
- Olinger GG; Saifuddin M; Spear GT; Department of Immunology/Microbiology, Rush University, Chicago,; Illinois 60612, USA.
- The ability of human immunodeficiency virus strain MN (HIV(MN)), a T-cell line-adapted strain of HIV, and X4 and R5 primary isolates to bind to various cell types was investigated. In general, HIV(MN) bound to cells at higher levels than did the primary isolates. Virus bound to both CD4-positive (CD4(+)) and CD4-negat
- Study of full-length porcine endogenous retrovirus genomes with envelope gene polymorphism in a specific-pathogen-free Large White swine herd.
- J Virol. 2000 Sep;74(18):8575-81. Unique Identifier : AIDSLINE GENBANK/AJ288592
- Bosch S; Arnauld C; Jestin A; Zoopole Developement, Rond Point du Zoopole, France.
- Specific-pathogen-free (SPF) swine appear to be the most appropriate candidate for pig to human xenotransplantation. Still, the risk of endogenous retrovirus transmission represents a major obstacle, since two human-tropic porcine endogenous retroviruses (PERVs) had been characterized in vitro (P. Le Tissier, J. P. St
- Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene.
- J Virol. 2000 Sep;74(18):8623-34. Unique Identifier : AIDSLINE GENBANK/AF145701
- Chen J; Ueda K; Sakakibara S; Okuno T; Yamanishi K; Department of Microbiology, Osaka University Medical School,; Osaka 565-0871, Japan.
- The Kaposi s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, open reading frame (ORF) K9 encodes a viral interferon regulatory factor (vIRF) that functions as a repressor for interferon-mediated signal transduction. Consequently, this gene is thought to play an important role in the tumorigenicity of KS
- Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imaging.
- Unique Identifier : AIDSLINE MED/20411441
- Hermida-Matsumoto L; Resh MD
- Budding of lentiviruses occurs at the plasma membrane, but the preceding steps involved in particle assembly are poorly understood. Since the Gag polyprotein mediates virion assembly and budding, studies on the localization of Gag within the cell should provide insight into the mechanism of particle assembly. Here, we
- Membrane targeting properties of a herpesvirus tegument protein-retrovirus Gag chimera.
- J Virol. 2000 Sep;74(18):8692-9. Unique Identifier : AIDSLINE MED/20411443
- Bowzard JB; Visalli RJ; Wilson CB; Loomis JS; Callahan EM; Courtney RJ; Wills JW; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.
- The retroviral Gag protein is capable of directing the production and release of virus-like particles in the absence of all other viral components. Budding normally occurs after Gag is transported to the plasma membrane by its membrane-targeting and binding (M) domain. In the Rous sarcoma virus (RSV) Gag protein, the
- Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.
- J Virol. 2000 Sep;74(18):8726-31. Unique Identifier : AIDSLINE MED/20411447
- Gobbi A; Stoddart CA; Locatelli G; Santoro F; Bare C; Linquist-Stepps V; Moreno ME; Abbey NW; Herndier BG; Malnati MS; McCune JM; Lusso P; Unit of Human Virology, Department of Biological and; Technological Research, San Raffaele Scientific Institute, 20132; Milan, Italy.
- Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicat
- Human immunodeficiency virus type 1 envelope epitope-specific CD4(+) T lymphocytes in simian/human immunodeficiency virus-infected and vaccinated rhesus monkeys detected using a peptide-major histocompatibility complex class II tetramer.
- J Virol. 2000 Sep;74(18):8751-6. Unique Identifier : AIDSLINE MED/20411451
- Kuroda MJ; Schmitz JE; Lekutis C; Nickerson CE; Lifton MA; Franchini G; Harouse JM; Cheng-Mayer C; Letvin NL; Division of Viral Pathogenesis, Department of Medicine, Beth; Israel Deaconess Medical Center, Harvard Medical School, Boston,; Massachusetts 02215, USA. mkuroda@caregroup.harvard.edu
- A tetrameric recombinant major histocompatibility complex (MHC) class II-peptide complex was used to quantitate human immunodeficiency virus type 1 (HIV-1) envelope (Env)-specific CD4(+) T cells in vaccinated and in simian/human immunodeficiency virus (SHIV)-infected rhesus monkeys. A rhesus monkey MHC class II DR mol
- Induction of mucosal homing virus-specific CD8(+) T lymphocytes by attenuated simian immunodeficiency virus.
- J Virol. 2000 Sep;74(18):8762-6. Unique Identifier : AIDSLINE MED/20411453
- Cromwell MA; Veazey RS; Altman JD; Mansfield KG; Glickman R; Allen TM; Watkins DI; Lackner AA; Johnson RP; Divisions of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, Massachusetts; 01772, USA.
- Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8(+) lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency vir
- The B-oligomer of pertussis toxin inhibits human immunodeficiency virus type 1 replication at multiple stages.
- J Virol. 2000 Sep;74(18):8767-70. Unique Identifier : AIDSLINE MED/20411454
- Alfano M; Pushkarsky T; Poli G; Bukrinsky M; The Picower Institute for Medical Research, Manhasset, New York; 11030, USA.
- We have recently demonstrated that the binding subunit (B-oligomer) of pertussis toxin (PTX-B) deactivates CCR5 and inhibits entry of R5 human immunodeficiency virus type 1 (HIV-1) strains in activated primary T lymphocytes (M. Alfano et al., J. Exp. Med. 190:597-605, 1999). We now present evidence that PTX-B also aff
- The 17 nucleotides downstream from the env gene stop codon are important for murine leukemia virus packaging.
- J Virol. 2000 Sep;74(18):8775-80. Unique Identifier : AIDSLINE MED/20411456
- Yu SS; Kim JM; Kim S; ViroMed Limited, Technology Business Incubator, Seoul 151-742,; Korea.
- We have identified a previously unknown nucleotide sequence important for the packaging of murine leukemia virus. This nucleotide sequence is located downstream from the stop codon of the env gene but does not overlap the polypurine tract. Deletion of 17 bp from this region resulted in a more than 10-fold decrease in
- [Surgical interventions in HIV-infected and patients with AIDS]
- Khirurgiia (Mosk). 2000;(7):46-50. Unique Identifier : AIDSLINE MED/20413943
- Smirnov GG; Buliskeriia TN; Khachatrian NN; Volodina V N; Arutiunian EN; Lazutkina LI
- 176 patients with HIV-infection and AIDS were examined. 77 of them underwent various surgical interventions the most frequent of which were: opening of abscess and phlegmons--14 (23%), biopsy of lymphatic nodes--10 (13.1%), appendectomy--5 (6.2%), condyloma excision--21 (27.2%), removal of uterus adnexa--2 (2.5%), ple
- [Hepatitis C more dangerous than AIDS. At last a breakthrough in therapy using the new combination treatment]
- Krankenpfl J. 1999 Nov;37(11):438-9. Unique Identifier : AIDSLINE MED/20157856
- Graft vasculopathy and tolerance: does the balance of Th cells contribute to graft vasculopathy?
- J Surg Res. 2000 Sep;93(1):28-34. Unique Identifier : AIDSLINE MED/20405751
- Hamano K; Bashuda H; Ito H; Shirasawa B; Okumura K; Esato K; First Department of Surgery, Yamaguchi University School of; Medicine, Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
- BACKGROUND: Cardiac allograft vasculopathy (CAV) is sometimes observed even though the allograft may survive indefinitely. In this study, we examined whether or not the preferential activation of Th2-type cells prevents the development of CAV. METHODS: Hearts from C57BL/10 mice were transplanted heterotopically into t
- Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.
- J Surg Res. 2000 Sep;93(1):63-9. Unique Identifier : AIDSLINE MED/20405755
- Turgeon NA; Iwakoshi NN; Phillips NE; Meyers WC; Welsh RM; Greiner DL; Mordes JP; Rossini AA; Departments of Medicine, Pathology, and Surgery, University of; Massachusetts Medical School, Worcester, Massachusetts 01605,; USA.
- BACKGROUND: Treatment with a single donor-specific transfusion (DST) plus a brief course of anti-CD154 monoclonal antibody (mAb) prolongs skin allograft survival in mice. It is known that prolongation of allograft survival by this method depends in part on deletion of alloreactive CD8(+) T cells at the time of toleran
- Primary colonic lymphoma.
- J Surg Oncol. 2000 Aug;74(4):257-62. Unique Identifier : AIDSLINE MED/20420081
- Doolabh N; Anthony T; Simmang C; Bieligk S; Lee E; Huber P; Hughes R; Turnage R; Department of Surgery, University of Texas Southwestern Medical; School, Dallas, Texas 75235, USA.
- BACKGROUND AND OBJECTIVES: The colon is a rare location for gastrointestinal non-Hodgkin s lymphoma (NHL). This study was undertaken to identify risk factors, presentation, treatment, and prognosis for primary colonic lymphoma (PCL) through review of a large tertiary care hospital
- HIV-1 suppression during acute scrub-typhus infection.
- Unique Identifier : AIDSLINE MED/20434771
- Watt G; Kantipong P; de Souza M; Chanbancherd P; Jongsakul K; Ruangweerayud R; Loomis-Price LD; Polonis V; Myint KS; Birx DL; Brown AE; Krishna S
- BACKGROUND: In HIV-1-infected individuals, viral load has been reported to rise transiently if an acute infection with another organism occurs. Our study was prompted by the unexpected finding that HIV-1 copy number fell during an acute infection with Orientia tsutsugamushi, the causative agent of scrub typhus. METHOD
- Public protests as Nigeria bans use of untested HIV vaccine [news]
- Lancet. 2000 Aug 5;356(9228):493. Unique Identifier : AIDSLINE MED/20434782
- Ahmad K
- AIDS: patent rights versus patient's rights.
- Lancet. 2000 Aug 5;356(9228):502. Unique Identifier : AIDSLINE MED/20434785
- Chirac P; von Schoen-Angerer T; Kasper T; Ford N; Medecins Sans Frontieres, Paris, France.
- Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
- Mol Pharmacol. 2000 Sep;58(3):641-8. Unique Identifier : AIDSLINE MED/20411480
- Pluymers W; Neamati N; Pannecouque C; Fikkert V; Marchand C; Burke TR Jr; Pommier Y; Schols D; De Clercq E; Debyser Z; Witvrouw M; Rega Institute for Medical Research, K. U. Leuven, Leuven,; Belgium.
- The antiviral activity of L-chicoric acid against HIV-1 has been attributed previously to the inhibition of HIV-1 integration. This conclusion was based on the inhibition of integrase activity in enzymatic assays and the isolation of a resistant HIV strain with a mutation (G140S) in the integrase gene. Here we show th
- CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.
- Mol Cell Biol. 2000 Sep;20(18):6958-69. Unique Identifier : AIDSLINE MED/20414704
- Garber ME; Mayall TP; Suess EM; Meisenhelder J; Thompson NE; Jones KA; Regulatory Biology Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.
- Human immunodeficiency virus type 1 (HIV-1) Tat interacts with cyclin T1 (CycT1), a regulatory partner of CDK9 in the positive transcription elongation factor (P-TEFb) complex, and binds cooperatively with CycT1 to TAR RNA to recruit P-TEFb and promote transcription elongation. We show here that Tat also stimulates ph
- [Expression of a fragment of the env gene, coding for the GP46 surface glycoprotein of the human T-cell leukemia virus, in Escherichia coli cells]
- Mol Gen Mikrobiol Virusol. 2000;(3):33-6. Unique Identifier : AIDSLINE MED/20430778
- Bondarenko VO; Kazennova EV; Bobkova MR; Prilipov AG; Bobkov AF; D. I. Ivanovsky Institute of Virology, Russian Academy of Medical; Sciences, Moscow.
- Designing of recombinant plasmids pSB2 and pSB3 with the 932 bp HTLV-II env gene inserts encoding the full-length surface membrane glycoprotein gp46 is described. Vectors pGOmpF and pET32a expressing genes cloned under control of the late bacteriophage T7 promoter were used. Western blot analysis of cellular proteins
- [Construction of original artificial immunogens--candidate vaccines against HIV-1]
- Mol Gen Mikrobiol Virusol. 2000;(3):36-40. Unique Identifier : AIDSLINE MED/20430779
- Lebedev LR; Gileva IP; Karpenko LI; Eroshkin AM; State Virology and Biotechnology Center Vektor, Berdsk,; Novosibirsk region.
- An original method for making effective artificial vaccines has been developed. Immunogens are virus-like particles containing a DNA molecule covered with recombinant proteins carrying the pathogen epitopes. The recombinant proteins are exposed on the surface of the particle and are attached to DNA via spermidine-poly
- Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice.
- Mutat Res. 2000 Jul 20;452(1):19-26. Unique Identifier : AIDSLINE MED/20355157
- Zhuang S; Soderkvist P; Division of Cell Biology, Department of Biomedicine and Surgery,; Faculty of Health Sciences, Linkoping University, Sweden.; shizh@mcb.liu.se
- We have previously identified activation of ras proto-oncogenes and inactivation of tumor suppressor genes including p53, p16(INK4a) and p15(INK4b) in 2 ,3 -dideoxycytidine ( ddC )- and/or 1,3-butadiene (BD)-induced lymphomas derived from B6C3F1 (C57BL/
- Life-threatening toxic epidermal necrolysis with thalidomide therapy for myeloma [letter]
- N Engl J Med. 2000 Sep 28;343(13):972-3. Unique Identifier : AIDSLINE MED/20441413
- Rajkumar SV; Gertz MA; Witzig TE
- Debt and poverty turn a disease into an epidemic [letter]
- Nature. 2000 Sep 7;407(6800):13. Unique Identifier : AIDSLINE MED/20445146
- Basu S; Mate K; Farmer PE
- The HIV glycoproteins gp41 and gp120 cause rapid excitation in rat cortical slices.
- Neurosci Lett. 2000 Sep 8;291(1):13-6. Unique Identifier : AIDSLINE MED/20420153
- Wang YS; White TD; Department of Pharmacology, Dalhousie University, Halifax, B3H; 4H7, Nova Scotia, Canada.
- Inflammation and associated excitotoxicity may play important roles in various neurodegenerative diseases including AIDS dementia . Here we show that exposure of rat parietal cortical slices to the HIV glycoproteins gp120 and gp41 triggered very rapid releases of the neurotransmitte
- Nothing personal.
- Nursing. 2000 Feb;30(2):88. Unique Identifier : AIDSLINE MED/20456106
- Denault J
- Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1.
- Pediatrics. 2000 Sep;106(3):540-6. Unique Identifier : AIDSLINE MED/20430135
- Howland LC; Gortmaker SL; Mofenson LM; Spino C; Gardner JD; Gorski H; Fowler MG; Oleske J; Center for Biostatistics in AIDS Research, Harvard School of; Public Health, Boston, Massachusetts, USA.; lois.howland@umassmed.edu
- OBJECTIVES: To evaluate the association of negative stressful life events experienced over 12 months and the risk of moderate to severe immune suppression among children and youth infected with human immunodeficiency virus type 1 (HIV-1). METHODS: Longitudinal study of 618 HIV-1-infected children, baseline ages 1 to 2
- Use of fenofibrate in the management of protease inhibitor-associated lipid abnormalities.
- Pharmacotherapy. 2000 Jun;20(6):727-34. Unique Identifier : AIDSLINE MED/20310676
- Thomas JC; Lopes-Virella MF; Del Bene VE; Cerveny JD; Taylor KB; McWhorter LS; Bultemeier NC; Department of Medicine, Medical University of South Carolina,; Charleston 29403, USA.
- Human immunodeficiency virus (HIV) protease inhibitors are associated with several metabolic abnormalities including hypercholesterolemia and hypertriglyceridemia. Fenofibrate is a new lipid-lowering agent for adults with very high triglyceride levels that was admin
- [Severe apnea: an early sign of Pneumocystis carinii pneumonia in an HIV-negative infant]
- Rev Med Chil. 2000 Apr;128(4):425-9. Unique Identifier : AIDSLINE MED/20418616
- Garcia CA; Delpiano L; Prado F; Ponce CA; Amaya M; Vargas SL; Universidad de Chile en el Hospital San Borja Arriaran, Santiago,; Chile.
- A few reports in the medical literature suggest an association between Pneumocystis caring and apnea in small infants. This patient, a 1 month 20 days old, HIV negative, infant girl weighing 2,000 grams was admitted to hospital after presenting a severe episode of apnea with cyanosis and bradycardia. She progressively
- [Anemia in HIV infection]
- Schweiz Rundsch Med Prax. 2000 Jun 8;89(23):1007-13. Unique Identifier : AIDSLINE MED/20367052
- Egloff N; Rossi M; Furrer H; Ambulatorium fur Infektionskrankheiten, Inselspital Bern.
- Anemia is a common finding in HIV-infected patients, especially in late stages of the disease. The grade of anemia is an independent marker for mortality. Beside the classical causes of anemia we find in HIV-infected patients typically cytokine mediated suppression of the bone marrow, infiltration of the latter by opp
- Forensic epidemiology. Vaccine theory of AIDS origins disputed at Royal Society [news]
- Science. 2000 Sep 15;289(5486):1850-1. Unique Identifier : AIDSLINE MED/20450089
- Cohen J
- How to resolve the debate on the origin of AIDS [letter]
- Science. 2000 Sep 15;289(5486):1877-8. Unique Identifier : AIDSLINE MED/20450100
- Hillis DM
- Future directions with platelet growth factors.
- Semin Hematol. 2000 Apr;37(2 Suppl 4):41-9. Unique Identifier : AIDSLINE MED/20290134
- Kuter DJ; Hematology/Oncology Unit, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA.
- Since the purification of thrombopoietin 6 years ago, c-Mpl ligands such as recombinant human thrombopoietin (rhTPO) and pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) have undergone extensive clinical investigation. Both recombinant forms have been shown to reduce the thrombocyt
- AZT blues [letter]
- S Afr Med J. 2000 Jul;90(7):656. Unique Identifier : AIDSLINE MED/20441130
- Lala SG; Cooper PA; Gray GE; Jivkov BI; Schorn MC
- Pneumocystis carinii pneumonia [letter]
- S Afr Med J. 2000 Jul;90(7):658. Unique Identifier : AIDSLINE MED/20441133
- Mahomed AG; Richards GA; Feldman C
- The HIV/AIDS pandemic in perspective [letter]
- S Afr Med J. 2000 Jul;90(7):658, 660. Unique Identifier : AIDSLINE MED/20441134
- Mokhobo KP
- IAPAC in AIDS e-education [news]
- S Afr Med J. 2000 Jul;90(7):676. Unique Identifier : AIDSLINE MED/20441137
- The provinces at a glance: who's spending what where? (Part 3).
- S Afr Med J. 2000 Jul;90(7):678-80. Unique Identifier : AIDSLINE MED/20441138
- Howse J
- Pneumocystis carinii pneumonia in HIV-infected patients in Africa--an important pathogen?
- S Afr Med J. 2000 Jul;90(7):684-8. Unique Identifier : AIDSLINE MED/20441140
- Zar HJ; Maartens G; Wood R; Hussey G; Department of Paediatrics, University of Cape Town.
- Affordability of home-based care for HIV/AIDS.
- S Afr Med J. 2000 Jul;90(7):690-1. Unique Identifier : AIDSLINE MED/20441141
- Haile B; University of California, Berkeley, USA.
- AIDS--time to act.
- S Afr Med J. 2000 Jul;90(7):691-2. Unique Identifier : AIDSLINE MED/20441142
- Dungwa N
- Awareness of HIV infection among pregnant women attending the Elsies River Antenatal Clinic.
- S Afr Med J. 2000 Jul;90(7):693-6. Unique Identifier : AIDSLINE MED/20441143
- du Plessis JK; Muller JB; Poolman M; Viljoen K; Barnes JM; Cotton MF
- [Hypersensitivity syndrome to nevirapine (letter)]
- Therapie. 2000 Mar-Apr;55(2):320-2. Unique Identifier : AIDSLINE MED/20423415
- Sibaud V; Billon C; Barcat D; Bernard N; Geniaux M
- [Myocardial infarct and severe angina after antiproteases: 4 cases (letter)]
- Therapie. 2000 May-Jun;55(3):399-402. Unique Identifier : AIDSLINE MED/20423429
- Hassoun S; Pisante L; Cattan S; Nallet O; Jarousse B; Jeantils V; Rosenheim M; Zemour G; Fauvelle F
- Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 18 March 1999. Fresh from the field: some controversies in tropical medicine and hygiene. HIV and malaria, do they interact?
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):233-7. Unique Identifier : AIDSLINE MED/20430684
- French N; Gilks CF; Liverpool School of Tropical Medicine, UK. nfrenc@aol.com
- Malaria and human immunodeficiency virus (HIV) infections are common, widespread and overlapping problems in the tropics. Despite this there has been minimal evidence to support an important interaction, other than during pregnancy in multigravid HIV-infected women. The lack of an interaction in other groups is surpri
- Relapse and recurrent tuberculosis in the context of a national tuberculosis control programme.
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):247-9. Unique Identifier : AIDSLINE MED/20430687
- Harries AD; Hargreaves NJ; Kwanjana JH; Salaniponi FM; National Tuberculosis Control Programme, Ministry of Health,; Lilongwe, Malawi. c-cruz@dfid.gtnet.gov.uk
- The proportion of patients with recurrent tuberculosis (TB) is reported to be increased in TB patients with human immunodeficiency virus (HIV) infection after they have completed treatment. Despite rising HIV seroprevalence amongst TB patients in Malawi , notifications of patients w
- RFLP patterns and risk factors for recent tuberculosis transmission among hospitalized tuberculosis patients in Rio de Janeiro, Brazil.
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):271-5. Unique Identifier : AIDSLINE MED/20430695
- Fandinho FC; Kritski AL; Hofer C; Junior Conde H; Ferreira RM; Saad MH; Silva MG; Riley LW; Fonseca LS; Laboratorio de Tecnologia Recombinante, Instituto de Tecnologia; em Imunobiologicos, Fiocruz, Rio de Janeiro, Brazil.
- Isolates of Mycobacterium tuberculosis from 120 tuberculosis patients seen in the 12 months ending September 1994 at 2 tertiary-care centres in Rio de Janeiro were characterized by IS6110 restriction fragment length polymorphism (RFLP) analysis. Ninety-seven patients (81%) had isolates with unique RFLP patterns, while
- Prevalence of human immunodeficiency virus infection among tuberculosis cases in some clinics in Dhaka, Bangladesh.
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):276. Unique Identifier : AIDSLINE MED/20430696
- Salimullah M; Tahera Y; Siddiqui MA; Salam MA; Rumi MA; Huq F; Hassan MS; Department of Immunology, Bangladesh Institute of Research and; Rehabilitation in Diabetes, Endocrine and Metabolic Disorders; (BIRDEM), Dhaka, Bangladesh.
- High mortality rates in tuberculosis patients in Zomba Hospital, Malawi, during 32 months of follow-up.
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):305-9. Unique Identifier : AIDSLINE MED/20430706
- Kang'ombe C; Harries AD; Banda H; Nyangulu DS; Whitty CJ; Salaniponi FM; Maher D; Nunn P; College of Medicine, Chichiri, Blantyre, Malawi.
- There is little information about long-term follow-up in patients with smear-negative pulmonary tuberculosis (PTB) or extrapulmonary tuberculosis (EPTB) who have been treated under routine programme conditions in sub-Saharan Africa. A prospective study was carried out to determine outcome 32 months from start of treat
- Clinical presentation of non-typhoidal Salmonella bacteraemia in Malawian children.
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):310-4. Unique Identifier : AIDSLINE MED/20430707
- Graham SM; Walsh AL; Molyneux EM; Phiri AJ; Molyneux ME; Department of Paediatrics, College of Medicine, Blantyre, Malawi.
- We report the clinical presentation and outcome of 299 Malawian children with non-typhoidal Salmonella (NTS) bacteraemia and no evidence of focal sepsis, admitted to Queen Elizabeth Central Hospital (QECH), Blantyre, over a 26-month period (February 1996-April 1998). A peak incidence during the rainy season was noted.
- HIV--Leishmania infantum co-infection: humoral and cellular immune responses to the parasite after chemotherapy.
- Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):328-32. Unique Identifier : AIDSLINE MED/20430713
- Moreno J; Canavate C; Chamizo C; Laguna F; Alvar J; WHO Collaborating Centre for Leishmaniasis, Research Unit in; Tropical Medicine and International Health (FIS-ISCIII),; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.; fjmoreno@isciii.es
- Specific serum antibodies, peripheral blood T-cell subsets, cellular response in vitro to soluble Leishmania antigens, phenotype of stimulated cells, and serum levels of tumour necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1 were studied in Spain in 17 patien
- [HIV-treatment. Interactions, compliance, prolonged adverse effects and global accessibility (editorial)]
- Ugeskr Laeger. 2000 Aug 28;162(35):4639. Unique Identifier : AIDSLINE MED/20442956
- Gerstoft J
- [HIV-treatment in Denmark and Africa--a world of differences]
- Ugeskr Laeger. 2000 Aug 28;162(35):4641-3. Unique Identifier : AIDSLINE MED/20442957
- Ullum H; Sondergaard SR; Skinhoj P; H:S Rigshospitalet, epidemiafdelingen.
- [Population screening for HIV in Sisimiut, Greenland]
- Ugeskr Laeger. 2000 Aug 28;162(35):4652-5. Unique Identifier : AIDSLINE MED/20442960
- Olsen OR; Koch A; Krause TG; Barselajsen G; Christiansen CB; Melbye M; Sisimiut Sundhedscenter, Gronland.
- INTRODUCTION: In the years 1985-1998, 91 HIV-positive persons were diagnosed in Greenland , resulting in an incidence of HIV infection three times higher in Greenland than in
- [Lactic acidosis type B. A life-threatening adverse effect of antiretroviral therapy]
- Ugeskr Laeger. 2000 Aug 28;162(35):4664-5. Unique Identifier : AIDSLINE MED/20442964
- Justesen US; Pedersen C; Odense Universitetshospital, medicinsk afdeling C.
- A thirty-year old HIV-positive woman, who had been receiving antiretroviral therapy (protease inhibitor, lamivudine and stavudine ) for seven months, was diagnosed with severe lactic acidosis type B, most likely induced by nucleoside reverse transcript
- [Picture of the month]
- Ugeskr Laeger. 2000 Aug 28;162(35):4666. Unique Identifier : AIDSLINE MED/20442965
- Roge BT; Epidemiafdelingen, H:S Rigshospitalet.
- [HIV protease inhibitors and interactions]
- Ugeskr Laeger. 2000 Aug 28;162(35):4677-81. Unique Identifier : AIDSLINE MED/20442969
- Justesen US; Brosen K; Pedersen C; Odense Universitetshospital, medicinsk afdeling C.
- The protease inhibitors are a new class of drugs for the treatment of HIV infection. Results of treatment have proved beneficial to HIV positive patients, resulting in slower disease progression to aids and death. However the potential of drug interactions is high b
- Molecular and biological interactions between two HIV-1 strains from a coinfected patient reveal the first evidence in favor of viral synergism.
- Virology. 2000 Aug 15;274(1):105-19. Unique Identifier : AIDSLINE MED/20396579
- Wang B; Lal RB; Dwyer DE; Miranda-Saksena M; Boadle R; Cunningham AL; Saksena NK; Retroviral Genetics Laboratory, Westmead Millennium Institutes; and Research Centres, Westmead Hospital, Westmead, New South; Wales 2145, Australia.
- An intravenous drug user was found to be dually infected with two genetically and phylogenetically distinct human immunodeficiency virus type 1 (HIV-1) subtype B strains (designated groups I and II). Viral isolation revealed a simultaneous copassaging of two strains in PBMC. The culture of viral strains on monocytes a
- Corf, the Rev/Rex homologue of HTDV/HERV-K, encodes an arginine-rich nuclear localization signal that exerts a trans-dominant phenotype when mutated.
- Virology. 2000 Aug 15;274(1):11-6. Unique Identifier : AIDSLINE GENBANK/X82272
- Magin C; Hesse J; Lower J; Lower R; Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, D-63225; Langen, Germany.
- Regulation of nucleo-cytoplasmic export of viral transcripts by a viral protein (Rev/Rex) is a characteristic feature in the replication cycle of complex retroviruses. We recently reported that the endogenous retrovirus family HTDV/HERV-K encodes a protein, Corf, that is a cellular Counterpart of Rev/Rex function and
- Production of functionally deficient dendritic cells from HTLV-I-infected monocytes: implications for the dendritic cell defect in adult T cell leukemia.
- Virology. 2000 Aug 15;274(1):140-8. Unique Identifier : AIDSLINE MED/20396581
- Makino M; Wakamatsu S; Shimokubo S; Arima N; Baba M; Division of Human Retroviruses, Center for Chronic Viral; Diseases, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima; 890-8520, Japan. makino-m@cb3.so-net.ne.jp
- Adult T cell leukemia (ATL) is induced by an infection with human T lymphotropic virus type I (HTLV-I) and is accompanied by immunodeficiency. Monocyte-derived immature dendritic cells (DCs) donated by 11 ATL patients were suppressed in the ability to take up fluorescein isothiocyanate (FITC)-dextran and were down-reg
- Evaluation of immune responses induced by HIV-1 gp120 in rhesus macaques: effect of vaccination on challenge with pathogenic strains of homologous and heterologous simian human immunodeficiency viruses.
- Virology. 2000 Aug 15;274(1):149-64. Unique Identifier : AIDSLINE MED/20396582
- Kumar A; Lifson JD; Silverstein PS; Jia F; Sheffer D; Li Z; Narayan O; Laboratory of Viral Pathogenesis, Department of Microbiology,; MolecularGenetics, and Immunolgy, University of Kansas Medical; Center, Kansas City, Kansas 66160, USA. Akumar@kumc.edu
- The simian human immunodeficiency virus (SHIV) macaque model of AIDS has provided a very useful system for evaluation of envelope-based candidate vaccines against HIV-1. Eight rhesus macaques were immunized with monomeric recombinant gp120 of HIV-1(LAI) (rgp120) and used to evaluate whether this vaccine conferred prot
- The HTLV-I orfI protein is recognized by serum antibodies from naturally infected humans and experimentally infected rabbits.
- Virology. 2000 Aug 15;274(1):86-93. Unique Identifier : AIDSLINE MED/20396577
- Dekaban GA; Peters AA; Mulloy JC; Johnson JM; Trovato R; Rivadeneira E; Franchini G; Gene Therapy and Molecular Virology Group, The John C. Roberts; ResearchInstitute, London, Ontario N6A 5K8, Canada.
- The mechanism of T-cell transformation by human T-cell lymphotropic virus type I (HTLV-I), though not completely understood, appears to involve the interactions of several viral and cellular proteins. One of these viral proteins, p12(I), encoded by HTLV-I orfI, is a weak oncogene that binds the 16-kDa subunit of the v
- Defining CTL-induced pathology: implications for HIV.
- Virology. 2000 Aug 15;274(1):94-104. Unique Identifier : AIDSLINE MED/20396578
- Wodarz D; Krakauer DC; Institute for Advanced Study, Olden Lane, Princeton, New Jersey; 08540, USA. wodarz@ias.edu
- The relationship between virus and host cells is multifactorial and nonlinear. This indicates that the effect of an immune response on infection can lead to several different outcomes. These include severe immunopathology. We seek to define properties of CTL-induced pathology in viral infections and examine the implic
- Whole body positron emission tomography imaging of activated lymphoid tissues during acute simian-human immunodeficiency virus 89.6PD infection in rhesus macaques.
- Virology. 2000 Sep 1;274(2):255-61. Unique Identifier : AIDSLINE MED/20423048
- Wallace M; Pyzalski R; Horejsh D; Brown C; Djavani M; Lu Y; Hanson JM; Mitchen JL; Perlman SB; Pauza CD; Department of Pathology and Laboratory Medicine, University of; Wisconsin, Madison, Wisconsin 53705-1532, USA.
- Mechanisms of acute retroviral pathogenesis have been examined during primary infection of rhesus macaques with simian-human immunodeficiency virus 89.6PD (SHIV(89.6PD)). During acute infection, between initial exposure and establishment of antigen-specific immune responses that stabilize the virus burden, rapid immun
- Analysis of the HIV-1 LTR NF-kappaB-proximal Sp site III: evidence for cell type-specific gene regulation and viral replication.
- Virology. 2000 Sep 1;274(2):262-77. Unique Identifier : AIDSLINE MED/20423049
- McAllister JJ; Phillips D; Millhouse S; Conner J; Hogan T; Ross HL; Wigdahl B; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.
- It has been widely demonstrated that the human immunodeficiency virus type 1 (HIV-1) envelope, specifically the V3 loop of the gp120 spike, evolves to facilitate adaptation to different cellular populations within an infected host. Less energy has been directed at determining whether the viral promoter, designated the
- An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
- Unique Identifier : AIDSLINE MED/20423057
- Sune C; Goldstrohm AC; Peng J; Price DH; Garcia-Blanco MA; Departments of Genetics, Duke University Medical Center, Durham,; North Carolina 27710, USA. csn@duke.edu
- Equine infectious anemia virus (EIAV) activates transcription via a Tat protein, a TAR element, and the equine elongation factor positive transcription elongation factor b (P-TEFb). In human cells, EIAV Tat (eTat) can inhibit the ability of human immunodeficiency virus type 1 (HIV-1) Tat (hTat) to activate transcripti
- Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development.
- Virology. 2000 Sep 1;274(2):391-401. Unique Identifier : AIDSLINE MED/20423060
- Beck ZQ; Hervio L; Dawson PE; Elder JH; Madison EL; Department of Molecular Biology, The Scripps Research Institute,; 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
- The recognition sequences for substrate cleavage by aspartic protease of HIV-1 are diverse and cleavage specificities are controlled by complex interactions between at least six amino acids around the cleavage site. We have identified 45 efficiently cleaved peptide substrates of HIV-1 protease (PR) using substrate pha
- Diversity of the HIV-1 long terminal repeat following mother-to-child transmission.
- Virology. 2000 Sep 1;274(2):402-11. Unique Identifier : AIDSLINE MED/20423061
- Blackard JT; Renjifo B; Chaplin B; Msamanga G; Fawzi W; Essex M; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, 651 Huntington Avenue, Boston, Massachusetts; 02115-6017, USA.
- A study of the human immunodeficiency virus Type 1 (HIV-1) 5 long terminal repeat (LTR) was performed to determine the extent of variation found within the LTR from 19 mother-infant pairs in Tanzania and to assess whether the LTR is useful in distinguishing maternal sequences th
- AIDS does not alter the total number of neurons in the hippocampal formation but induces cell atrophy: a stereological study.
- Acta Neuropathol (Berl). 2000 Jun;99(6):643-53. Unique Identifier : AIDSLINE MED/20325751
- Sa MJ; Madeira MD; Ruela C; Volk B; Mota-Miranda A; Lecour H; Goncalves V; Paula-Barbosa MM; Department of Anatomy, Porto Medical School, Portugal.; insanato@med.up.pt
- Although cognitive dysfunction is a common finding in patients with acquired immunodeficiency syndrome (AIDS) its pathogenesis remains controversial. Given the involvement of the hippocampal formation in the processing of cognitive information and the scarcity of quantitative studies in this brain region, we have exam
- Use of rifamycins in HIV-infected patients [news]
- Am Fam Physician. 2000 Sep 1;62(5):1189-90. Unique Identifier : AIDSLINE MED/20450344
- Preboth M
- Status of selected nutrients and progression of human immunodeficiency virus type 1 infection.
- Am J Clin Nutr. 2000 Sep;72(3):809-15. Unique Identifier : AIDSLINE MED/20424619
- Bogden JD; Kemp FW; Han S; Li W; Bruening K; Denny T; Oleske JM; Lloyd J; Baker H; Perez G; Kloser P; Skurnick J; Louria DB; Department of Preventive Medicine and Community Health, the; University of Medicine and Dentistry of New Jersey-New Jersey; Medical School, Newark. bogden@umdnj.edu
- BACKGROUND: Immune function is highly dependent on nutritional status because the large mass and high rate of cellular turnover of the immune system make it a major user of nutrients. Furthermore, nutrient requirements may be increased during acute and chronic infections, including HIV-1 infection. OBJECTIVE: The curr
- Special histologic stains are rarely beneficial for the evaluation of HIV-related gastrointestinal infections.
- Am J Clin Pathol. 2000 Sep;114(3):387-94. Unique Identifier : AIDSLINE MED/20444841
- Monkemuller KE; Bussian AH; Lazenby AJ; Wilcox CM; Department of Medicine, University of Alabama at Birmingham,; 35294-0007, USA
- During a 28-month period, endoscopic mucosal biopsy specimens from all HIV-infected patients were submitted for routine histologic evaluation. Immunoperoxidase staining for cytomegalovirus and herpesvirus antigens (esophagus), mycobacterial and fungal staining, and Gram staining of
- Oral hairy leukoplakia. Histopathologic and cytopathologic features of a subclinical phase.
- Am J Clin Pathol. 2000 Sep;114(3):395-401. Unique Identifier : AIDSLINE MED/20444842
- Dias EP; Rocha ML; Silva JuniorA; Spyrides KS; Ferreira SM; Polignano GA; Feijo EC; Da Fonseca EC; Department of Pathology, Universidade Federal Fluminense,; Niteroi/RJ, Brazil.
- Accurate diagnosis of oral hairy leukoplakia (OHL) is important because it may be an early indicator of undiagnosed HIV infection; moreover, it may be a prognostic indicator. Our purpose was to investigate the histopathologic features of subclinical OHL and to evaluate and support the rationale of detecting subclinica
- Neutrophil-rich anaplastic large cell lymphoma of T-cell lineage. A report of two cases arising in HIV-positive patients.
- Unique Identifier : AIDSLINE MED/20444851
- Jhala DN; Medeiros LJ; Lopez-Terrada D; Jhala NC; Krishnan B; Shahab I
- Neutrophil-rich anaplastic large cell lymphoma (ALCL) is an uncommon morphologic variant of ALCL. We report 2 cases of neutrophil-rich T-cell ALCL that presented as scalp masses in HIV-positive men. Histologically, the neoplastic cells extensively infiltrated the dermis and subcutaneous tissue. The neoplastic cells st
- Effects of maternal allergen-specific IgG in cord blood on early postnatal development of allergen-specific T-cell immunity.
- Allergy. 2000 May;55(5):470-5. Unique Identifier : AIDSLINE MED/20300414
- Prescott SL; Holt PG; Jenmalm M; Bjorksten B; Department of Paediatrics, University of Western Australia, West; Perth, Australia.
- BACKGROUND: A wide body of epidemiologic evidence indicates that as yet unknown maternal factor(s) can influence susceptibility to allergic disease in the offspring. It is also well established that the induction of allergen-specific T-cell memory is frequently initiated in utero, and it is likely that maternal factor
- A high-throughput homogeneous assay for reverse transcriptase using generic reagents and time-resolved fluorescence detection.
- Anal Biochem. 2000 Jun 1;281(2):182-6. Unique Identifier : AIDSLINE MED/20326648
- Zhang JH; Chen T; Nguyen SH; Oldenburg KR; DuPont Pharmaceuticals Research Laboratories, Wilmington,; Delaware 19880-0400, USA. ji-hu.zhang@dupontpharma.com
- A homogeneous time-resolved fluorescence (HTRF) assay has been developed for determining the activity of HIV reverse transcriptase (HIV-RT). By using a sequential capping strategy, the assay has been configured to utilize only generic reagents such as biotinylated dUTP, streptavidin-allophycocyanin, and streptavidin-e
- A single oral dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2286-90. Unique Identifier : AIDSLINE MED/20408548
- Verbon A; Juffermans NP; Speelman P; van Deventer SJ; ten Berge IJ; Guchelaar HJ; van der Poll T; Department of Infectious Diseases, Tropical Medicine and AIDS,; Academic Medical Center, University of Amsterdam, The; Netherlands. A.verbon@amc.uva.nl
- Thalidomide is increasingly being used as adjuvant therapy for patients with mycobacterial and human immunodeficiency virus (HIV) infections. The T-helper (Th)1 cytokine-Th2 cytokine balance critically determines the outcomes of these diseases. To obtain insight into the effect of thalidomide on the capacity of lympho
- Transcriptional analyses of antifungal drug resistance in Candida albicans.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2296-303. Unique Identifier : AIDSLINE MED/20408550
- Lyons CN; White TC; Department of Pathobiology, School of Public Health and Community; Medicine, University of Washington and the Seattle Biomedical; Research Institute, 98109-1651, USA.
- Oral infections with the pathogenic yeast Candida albicans are one of the most frequent and earliest opportunistic infections in human immunodeficiency virus-infected patients. The widespread use of azole antifungal drugs has led to the development of drug-resistant isolates. Several molecular mechanisms that contribu
- In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS-232632.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2319-26. Unique Identifier : AIDSLINE MED/20408553
- Gong YF; Robinson BS; Rose RE; Deminie C; Spicer TP; Stock D; Colonno RJ; Lin PF; Departments of Virology, Bristol-Myers Squibb Company,; Wallingford, Connecticut 06492, USA.
- BMS-232632 is an azapeptide human immunodeficiency virus (HIV) type 1 (HIV-1) protease inhibitor that displays potent anti-HIV-1 activity (50% effective concentration [EC(50)], 2.6 to 5.3 nM; EC(90), 9 to 15 nM). In vitro passage of HIV-1 RF in the presence of inhibitors showed that BMS-232632 selected for resistant v
- Antiviral therapy reduces viral burden but does not prevent thymic involution in young cats infected with feline immunodeficiency virus.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2399-405. Unique Identifier : AIDSLINE MED/20408565
- Hayes KA; Phipps AJ; Francke S; Mathes LE; Department of Veterinary Biosciences, The Ohio State University,; Columbus 43210, USA.
- The thymus is a major target organ in human immunodeficiency virus type 1 (HIV-1)-infected children and feline immunodeficiency virus (FIV)-infected young cats (G. A. Dean and N. C. Pedersen, J. Virol. 72:9436-9440, 1998; J. L. Heeney, Immunol. Today 16:515-520, 1995; S. M. Schnittman et al., Proc. Natl. Acad. Sci. US
- Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2475-84. Unique Identifier : AIDSLINE MED/20408577
- Bacheler LT; Anton ED; Kudish P; Baker D; Bunville J; Krakowski K; Bolling L; Aujay M; Wang XV; Ellis D; Becker MF; Lasut AL; George HJ; Spalding DR; Hollis G; Abremski K; DuPont Pharmaceuticals Company, Experimental Station, Wilmington,; Delaware 19880-0336, USA. lee.bacheler@dupontpharma.com
- Efavirenz is a potent and selective nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Nucleotide sequence analyses of the protease and RT genes (coding region for amino acids 1 to 229) of multiple clone
- Use of saliva specimens for monitoring indinavir therapy in human immunodeficiency virus-infected patients.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2572-4. Unique Identifier : AIDSLINE MED/20408601
- Wintergerst U; Kurowski M; Rolinski B; Muller M; Wolf E; Jaeger H; Belohradsky BH; Department of Infectious Diseases and Immunology, Federal; Republic of Germany. uwe.wintergerst@KK-i.med.uni-muenchen.de
- Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% +/- 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen f
- Anti-toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro.
- Antimicrob Agents Chemother. 2000 Sep;44(9):2575-7. Unique Identifier : AIDSLINE MED/20408602
- Derouin F; Santillana-Hayat M; Laboratoire de Parasitologie-Mycologie, Faculte de; Medecine-Hopital Saint-Louis, Paris, France.; paracord@wanadoo.fr
- The anti-Toxoplasma activities of nine antiretroviral drugs were examined in vitro. Nucleoside analogs had no effect on parasite growth, whereas ritonavir and nelfinavir were inhibitory for Toxoplasma, with 50% inhibitory concentrations of 5.4 and 4.0
- Efavirenz-induced decrease in plasma amprenavir levels in human immunodeficiency virus-infected patients and correction by ritonavir [letter]
- Unique Identifier : AIDSLINE MED/20421405
- Duval X; Le Moing V; Longuet C; Leport C; Vilde JL; Lamotte C; Peytavin G; Farinotti R
- Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS Research Group.
- Unique Identifier : AIDSLINE MED/20437695 P
- Holbrook JT; Davis MD; Hubbard LD; Martin BK; Holland GN; Jabs DA; Gilpin AK; Meinert C; Reshef DS
- Functions of tetramer-stained HIV-specific CD4(+) and CD8(+) T cells.
- Curr Opin Immunol. 2000 Aug;12(4):370-4. Unique Identifier : AIDSLINE MED/20360114
- Kelleher AD; Rowland-Jones SL; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, OX3 9DS, UK.; kelleher@worf.molbiol.ox.ac.uk
- Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HI
- The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.
- Curr Opin Immunol. 2000 Aug;12(4):375-80. Unique Identifier : AIDSLINE MED/20360115
- Altfeld M; Rosenberg ES; Partners AIDS Research Center, Massachusetts General Hospital,; Harvard Medical School, Charlestown, MA 02114, USA.; Maltfeld@partners.org
- Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-1-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over
- The CD4(+) T cell response to HIV-1.
- Curr Opin Immunol. 2000 Aug;12(4):381-6. Unique Identifier : AIDSLINE MED/20360116
- Picker LJ; Maino VC; Vaccine and Gene Therapy Institute, Oregon Health Sciences; University, Mail Code L220, Portland, OR 97201-3098, USA.; pickerl@ohsu.edu
- Although virus-specific CD4(+) T cells have proven to be a critical component of the immunologic control of chronic viral infections in a number of models, the role and even the existence of HIV-1-specific CD4(+) T cells in human HIV-1 infection has been controversial. Recent advances in quantifying and functionally c
- The immune response to HTLV-I.
- Curr Opin Immunol. 2000 Aug;12(4):397-402. Unique Identifier : AIDSLINE MED/20360118
- Bangham CR; Department of Immunology, Imperial College School of Medicine,; London, W2 1PG, UK. c.bangham@ic.ac.uk
- A strong cytotoxic T lymphocyte response to HTLV-I protects against the associated inflammatory disease of the central nervous system, HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis), by reducing the proviral load of HTLV-I; however, when the proviral load exceeds a threshold level, HTLV-I-specific
- Immune responses in tuberculosis.
- Curr Opin Immunol. 2000 Aug;12(4):432-6. Unique Identifier : AIDSLINE MED/20360124
- Flynn JL; Ernst JD; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; joanne@pitt.edu
- The initial interaction of Mycobacterium tuberculosis with phagocytes through Toll-like receptors can affect induction of the adaptive response by inflammatory cytokine production, as well as begin the process of bacterial containment by induction of antimycobacterial functions. Advances in T cell research in tubercul
- DNA vaccines: a key for inducing long-term cellular immunity.
- Curr Opin Immunol. 2000 Aug;12(4):442-7. Unique Identifier : AIDSLINE MED/20360126
- Gurunathan S; Wu CY; Freidag BL; Seder RA; Clinical Immunology Section, Laboratory of Clinical; Investigation, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- Over the past few years, major advances in several areas of immunology have provided a foundation for the rational design of vaccines against diseases requiring cellular immunity. Among these advances are the cellular mechanisms by which DNA vaccines can sustain long-term humoral and cellular immunity.
- Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses.
- Curr Opin Immunol. 2000 Aug;12(4):448-55. Unique Identifier : AIDSLINE MED/20360127
- Whitmire JK; Ahmed R; Department of Molecular Immunology, La Jolla Institute for; Allergy and Immunology, San Diego, CA 92121, USA.; jwhitmire@mail.liai.org
- A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4(+) and CD8(+) T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions ca
- Partner notification in the United States: an evidence-based review.
- Am J Prev Med. 1999 Oct;17(3):230-42. Unique Identifier : AIDSLINE MED/20441946
- Macke BA; Maher JE; Division of STD Prevention, National Center for HIV, STD, and TB; Prevention, Office of Communications, Centers for Disease Control; and Prevention, Atlanta, Georgia 30333, USA.
- INTRODUCTION: To conduct an evidence-based review of the literature on the effectiveness of partner notification strategies for syphilis, gonorrhea, chlamydia, and human immunodeficiency virus (HIV) in the United States . METHODS: Systematic literature searches of available databases yi
- Impact of infant feeding practices on the risk of mother to child transmission of HIV-1 in Zimbabwe.
- J Paediatr Child Health. 2000 Aug;36(4):313-7. Unique Identifier : AIDSLINE MED/20398512
- Olayinka Ba; Oni AO; Mbajiorgu FE; Department of Obstetrics and Gynaecology, University of Zimbabwe; Medical School, Avondale, Harare. olayinka_ba@yahoo.com
- OBJECTIVE: To determine the magnitude of the contribution of infant feeding practices on the risk of mother to child transmission (MTCT) of the HIV-1 infection. METHODOLOGY: Prospective data from birth until 24 months of age on 236 infants born to HIV-positive mothers in Harare, Zimb
- Hepatitis C infection in children: a Melbourne perspective.
- J Paediatr Child Health. 2000 Aug;36(4):385-8. Unique Identifier : AIDSLINE MED/20398528
- Karim B; Alex G; Smith AL; Hardikar W; Department of Gastroenterology and Clinical Nutrition, Royal; Children's Hospital, Melbourne, Victoria, Australia.
- OBJECTIVE: To examine the clinical spectrum of hepatitis C virus (HCV) infected children in our care by determining presentation, mode of acquisition, degree of co-infection, biochemical evidence of persisting hepatitis and treatment outcome. METHODOLOGY: A retrospective review of the medical records of all children a
- Restriction of T-cell receptor repertoires in idiopathic CD4+ lymphocytopenia.
- Br J Haematol. 2000 Aug;110(2):434-7. Unique Identifier : AIDSLINE MED/20430021
- Signorini S; Pirovano S; Fiorentini S; Stellini R; Bianchi V; Albertini A; Imberti L; Terzo Laboratorio Analisi, Spedali Civili and Institute of; Chemistry, University of Brescia, Brescia, Italy.
- We report that alpha/beta and gamma/delta T-cell repertoires of three patients with idiopathic CD4+ lymphocytopenia, who showed different clinical manifestations and outcomes over time, were highly restricted. The disruption of T-cell repertoires does not influence the susceptibility to infections: the first patient w
- Active CMV infection before lung transplantation: risk factors and clinical implications.
- J Heart Lung Transplant. 2000 Aug;19(8):744-50. Unique Identifier : AIDSLINE MED/20424665
- Milstone AP; Brumble LM; Loyd JE; Ely EW; Roberts JR; Pierson RN 3rd; Dummer JS; Department of Allergy, Pulmonary and Critical Care, Vanderbilt; University, Nashville, Tennessee, USA.
- BACKGROUND: Cytomegalovirus ( CMV ) infection is a major cause of morbidity following lung transplantation, but active CMV infection has not been described before transplantation.Since 1990, we have screened all lung-transplant recipients for CMV infection with vi
- Interactions of the HIV-1 fusion peptide with large unilamellar vesicles and monolayers. A cryo-TEM and spectroscopic study.
- Biochim Biophys Acta. 2000 Jul 31;1467(1):153-64. Unique Identifier : AIDSLINE MED/20439541
- Agirre A; Flach C; Goni FM; Mendelsohn R; Valpuesta JM; Wu F; Nieva JL; Unidad de Biofisica (CSIC-EHU/UPV) y Departamento de Bioquimica,; Universidad del Pais Vasco, Bilbao, Spain.
- We have examined the interaction of the human immunodeficiency virustype 1 fusion peptide (23 amino acid residues) and of a Trp-containing analog with vesicles composed of dioleoylphosphatidylcholine, dioleoylphosphatidylethanolamine and cholesterol (molar ratio, 1:1:1). Both the native and the Trp-substituted peptide
- Tris(3-mercaptopropyl)-N-glycylaminomethane as a new linker to bridge antibody with metal particles for biological cell separations.
- Bioconjug Chem. 2000 Jul-Aug;11(4):549-56. Unique Identifier : AIDSLINE MED/20356963
- Siiman O; Burshteyn A; Maples JA; Whitesell JK; Advanced Technology, Beckman Coulter, Inc., 11800 SW 147th; Avenue, Miami, Florida 33196-2500, USA. olavi.siiman@coulter.com
- Conjugates of nickel beads with CD8 and anti-red blood cell KC16 antibody were prepared by using the aminotrithiolate spider ligand, tris(3-mercaptopropyl)-N-glycylaminomethane, in its new function as a linker between the surface of nickel beads and antibody via activation of spider ligand attached to nickel beads w
- [Central nervous system tuberculomas seen on positive SPECT in a patient with AIDS and multiresistant tuberculosis (letter)]
- Enferm Infecc Microbiol Clin. 2000 Apr;18(4):192-4. Unique Identifier : AIDSLINE MED/20387772
- Corti ME; Miller K; Trione N; Villafane MF; Soto I
- [Chagas disease: another cause of cerebral mass occurring in patients with acquired immunodeficiency syndrome (letter)]
- Enferm Infecc Microbiol Clin. 2000 Apr;18(4):194-6. Unique Identifier : AIDSLINE MED/20387773
- Corti M; Trione N; Corbera K; Vivas C
- [Protozoan diarrhea in patients with positive serology for the human immunodeficiency virus at the time of highly-active retroviral treatment]
- Enferm Infecc Microbiol Clin. 2000 Apr;18(4):200. Unique Identifier : AIDSLINE MED/20387777
- del Arco A; Poveda F; Prada JL; de la Torre J; Garcia-Alegria J
- Biological hazards: an overview.
- Occup Med (Lond). 2000 Aug;50(6):375-6. Unique Identifier : AIDSLINE MED/20449689
- Payton C; Royal United Hospital Bath NHS Trust, UK.; colin.payton@ruh-bath.swest.nhs.uk
- Recent developments include new guidance from the UK Department of Health on the management of hepatitis B infected healthcare workers and evidence of the value of antiretroviral treatment in reducing transmission of HIV. The possibility of greater occupational transmissibility of hepatitis C and increasing antibiotic
- Hepatitis C virus: an important occupational hazard?
- Unique Identifier : AIDSLINE MED/20449690
- Stevens AB; Coyle PV
- Infection with Hepatitis C virus (HCV) is estimated to affect 3% of the world s population and is an important cause of liver disease. It is most commonly transmitted by percutaneous exposure. Although current evidence does not suggest an increased prevalence of HCV infection among healthcare workers, transmission of
- Occupational exposure to HIV and post-exposure prophylaxis in healthcare workers.
- Occup Med (Lond). 2000 Aug;50(6):387-91. Unique Identifier : AIDSLINE MED/20449692
- Kennedy I; Williams S; Occupational Health and Safety Unit, Royal Free Hampstead NHS; Trust, London, UK.
- Healthcare workers are at risk of occupationally acquired HIV infection primarily due to percutaneous exposure to HIV infected blood. The average risk of HIV transmission after such exposure is approximately 0.3%. There is evidence of higher risk for exposures involving an increased volume of blood (deep injury, injur
- High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients.
- Blood. 2000 Sep 15;96(6):2069-73. Unique Identifier : AIDSLINE MED/20435333
- Oksenhendler E; Carcelain G; Aoki Y; Boulanger E; Maillard A; Clauvel JP; Agbalika F; Department of Immunology and Hematology, Laboratory of Virology,; Hopital Saint-Louis, Paris, France. oksenhendler@chu-stlouis.fr
- Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23
- Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine.
- Blood. 2000 Sep 15;96(6):2074-80. Unique Identifier : AIDSLINE MED/20435334
- Onai N; Zhang Yy; Yoneyama H; Kitamura T; Ishikawa S; Matsushima K; Department of Molecular Preventive Medicine and CREST, School of; Medicine, University of Tokyo, Tokyo, Japan.
- Both SDF-1 and CXCR4 disruption are lethal to mice at the embryonic stage and cause abnormalities in B lymphopoiesis, myelopoiesis, cardiogenesis, vasculogenesis, and cerebellar development. To investigate the role of SDF-1 and CXCR4 in hematopoiesis during the adult stage, mice reconstituted with bone marrow-derived
- Lack of serologic association of human herpesvirus-8 (KSHV) in patients with monoclonal gammopathy of undetermined significance with and without progression to multiple myeloma.
- Blood. 2000 Sep 15;96(6):2304-6. Unique Identifier : AIDSLINE MED/20435365
- Ablashi DV; Chatlynne L; Thomas D; Bourboulia D; Rettig MB; Vescio RA; Viza D; Gill P; Kyle RA; Berenson JR; Whitman JE; Advanced Biotechnologies Inc, Columbia, MD 21046-2701, USA.; dablashi@abionline.com
- Because human herpesvirus-8 (HHV-8) DNA has been found in multiple myeloma (MM) patients by polymerase chain reaction, it was suggested that HHV-8 may play a role in the transformation of monoclonal gammopathy of undetermined significance (MGUS) to MM. Therefore, 362 MGUS sera with and without progression to MM were t
- Effects of treatment or/and vaccination on HIV transmission in homosexuals with genetic heterogeneity.
- Math Biosci. 2000 Sep;167(1):1-18. Unique Identifier : AIDSLINE MED/20402247
- Hsu Schmitz S; Institut fur Mathematische Statistik und Versicherungslehre; (IMSV), Universitat Bern, 3012, Bern, Switzerland.; shu-fang.hsu@stat.unibe.ch
- Several mutant genes in HIV co-receptors (e.g., CCR5, CCR2 and CXCR4) have been correlated with susceptibility to HIV or/and rate of progression to AIDS. Some of these genes have high allele frequencies in general populations. Their effects on the HIV/AIDS dynamics may be significant. To study such genetic heterogenei
- Estimation of HIV infection and incubation via state space models.
- Math Biosci. 2000 Sep;167(1):31-50. Unique Identifier : AIDSLINE MED/20402249
- Tan WY; Ye Z; Department of Mathematical Sciences, The University of Memphis,; 335 Winfield Dunn, Memphis, TN 38152, USA. waitan@memphis.edu
- By using the state space model (Kalman filter model) of the HIV epidemic, in this paper we have developed a general Bayesian procedure to estimate simultaneously the HIV infection distribution, the HIV incubation distribution, the numbers of susceptible people, infective people and AIDS cases. The basic approach is to
- An intuitive formulation for the reproductive number for the spread of diseases in heterogeneous populations.
- Math Biosci. 2000 Sep;167(1):65-86. Unique Identifier : AIDSLINE MED/20402251
- Hyman JM; Li J; Theoretical Division, MS-B284, Center for Nonlinear Studies, Los; Alamos National Laboratory, Los Alamos, NM 87545, USA.
- The thresholds for mathematical epidemiology models specify the critical conditions for an epidemic to grow or die out. The reproductive number can provide significant insight into the transmission dynamics of a disease and can guide strategies to control its spread. We define the mean number of contacts, the mean dur
- The future of research into rotavirus vaccine [editorial]
- BMJ. 2000 Sep 2;321(7260):525-6. Unique Identifier : AIDSLINE MED/20424806
- Weijer C
- HIV vaccine trials begin in Oxford [news]
- BMJ. 2000 Sep 9;321(7261):591. Unique Identifier : AIDSLINE MED/20433179
- Fazal A
- Structural biology of chemokine receptors.
- Biol Res. 1999;32(4):263-72. Unique Identifier : AIDSLINE MED/20438978
- Rojo D; Suetomi K; Navarro J; Department of Physiology and Biophysics, University of Texas; Medical Branch, Galveston 77555-0641, USA. drojo@email.utmb.edu
- Chemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection. In addition, chemokine receptors are used by HIV-1 to infect CD4 positive cells. The structural bases of chemokine receptor recognition a
- Surveillance of health care workers exposed to bloodborne viruses at work: July 1997 to June 2000.
- Commun Dis Rep CDR Wkly. 2000 Aug 18;10(33):293. Unique Identifier : AIDSLINE MED/20434243
- AIDS and HIV infection in the United Kingdom: monthly report.
- Commun Dis Rep CDR Wkly. 2000 Aug 25;10(34):309-10. Unique Identifier : AIDSLINE MED/20440984
- New guidelines on post exposure prophylaxis for HIV.
- Commun Dis Rep CDR Wkly. 2000 Sep 1;10(35):311, 314. Unique Identifier : AIDSLINE MED/20447548
- Correlates of unprotected vaginal sex among African American female adolescents: importance of relationship dynamics.
- Arch Pediatr Adolesc Med. 2000 Sep;154(9):893-9. Unique Identifier : AIDSLINE MED/20437806
- Crosby RA; DiClemente RJ; Wingood GM; Sionean C; Cobb BK; Harrington K; Department of Behavioral Sciences and Health Education, Rollins; School of Public Health of Emory University, 1518 Clifton Rd NE,; Room 520, Atlanta, GA 30333, USA. rcrosby@sph.emory.edu
- OBJECTIVE: To determine the associations between the frequency of unprotected vaginal sex (UVS) and female adolescents perceptions, particularly their perceptions of relationship dynamics. DESIGN: Cross-sectional study of 522 African American female adolescents enrolled in a sexually transmitted disease (STD) and hum
- The effects of lithium gamma-linolenic acid in reversing LPBM5 MuLV induced suppression of hematopoietic progenitor cells in vitro.
- Rom J Physiol. 1998 Jan-Jun;35(1-2):13-24. Unique Identifier : AIDSLINE MED/20456119
- Oakley OR; Hughes NK; Birch NJ; Winther ML; Horrobin DF; Gallicchio VS; Biomedical Research Laboratory, School of Health Sciences,; University of Wolverhampton, UK.
- Lithium gamma linolenic acid (Li-GLA), was evaluated for its possible role as an antiviral agent. Li-GLA 15 micrograms ml-1 was administered to both normal and LP-BM5 MuLV retroviral infected murine bone marrow cultures. After 2 weeks of treatment, numbers of progenitors being produced by infected/treated cultures wer
- The effects of lithium in reversing hydroxyurea induced suppression of hematopoietic progenitor cells in vitro using retroviral infected long-term marrow cultures.
- Rom J Physiol. 1998 Jan-Jun;35(1-2):67-78. Unique Identifier : AIDSLINE MED/20456125
- Oakley OR; Hughes NK; Phillips JD; Birch NJ; Gallicchio VS; Biomedical Research Laboratory, School of Health Sciences,; University of Wolverhampton, UK.
- Lithium has been known for its ability to induce the production of hematopoietic cells following administration in vivo to minimize the toxic effects on hematopoiesis as a consequence of drug treatment. The drug hydroxyurea (HU), a ribonucleotide reductase inhibitor, has been used in the treatment of a variety of neop
- Diethylaminoethanol action in the arthritis with Freund adjuvant, in rats.
- Rom J Physiol. 1998 Jan-Jun;35(1-2):99-110. Unique Identifier : AIDSLINE MED/20456129
- Vrabiescu A; Poli T; Coman G; Dolcos F; Gainaru C; Carazanu C; Ciobanu G; Ana Aslan Foundation, Bucharest, Romania.
- The authors have studied the action of diethylaminoethanol on Freund adjuvant arthritis, induced in female Lewis rats. They worked on 3 groups, each one including 14 rats, weighing 110-130 g: group I = control; group II = rats injected intracutaneous with 0.1 ml Freund adjuvant; group III = rats injected with Freund a
- Commitment factors for T helper cells.
- Curr Biol. 2000 Jun 29;10(13):R492-4. Unique Identifier : AIDSLINE MED/20360172
- O'Garra A; Division of Immunology, DNAX Research Institute of Molecular and; Cellular Biology, Palo Alto, CA 94304-1104, USA.
- Cytokines are dominant factors in driving the development of T helper cell subsets via specific signaling pathways. Transcription factors specific to the T helper cell lineages have also been shown to determine the commitment of Th1 and Th2 cells to the production of distinct profiles of cytokines.
- Human immunodeficiency virus disease: natural history and management.
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Sep;90(3):266-70. Unique Identifier : AIDSLINE MED/20440255
- Depaola LG; Department of Oral Medicine and Diagnostic Sciences Dental; School, University of Maryland at Baltimore and Pennsylvania; Mid-Atlantic AIDS Education and Training Center, USA.
- Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry.
- Eur J Oral Sci. 2000 Jun;108(3):195-201. Unique Identifier : AIDSLINE MED/20329390
- Walker KF; Lappin DF; Takahashi K; Hope J; Macdonald DG; Kinane DF; Peridontology & Oral Immunology Group, Glasgow Dental Hospital; and School, Scotland, UK.
- The aims of this study were to investigate the expression of pro-inflammatory, anti-inflammatory and immune-related cytokines present in periapical lesions. We investigated the expression of cytokines: namely interleukins IL-2 , IL-4, IL-6, IL-10 and interferon-gamma (I
- Doctor-to-patient transmission of viral hepatitis B: is it a problem, is there a solution?
- J Viral Hepat. 2000 Jul;7(4):245-9. Unique Identifier : AIDSLINE MED/20345255
- Schalm SW; van Wijngaarden JK; Department of Hepatogastroenterology, University Hospital; Rotterdam, the Netherlands.
- It is well-established that hepatitis B may be transmitted from surgeons to their patients. Clear strategies are needed to reduce the risk of transmission whilst not discriminating unnecessarily against surgeons who may pose no risks to their patients. This review outlines the current position and provides a blueprint
- Hepatitis C is more severe in drug users with human immunodeficiency virus infection.
- J Viral Hepat. 2000 Jul;7(4):297-301. Unique Identifier : AIDSLINE MED/20345263
- Romeo R; Rumi MG; Donato MF; Cargnel MA; Vigano P; Mondelli M; Cesana B; Colombo M; Department of Internal Medicine, IRCCS, Ospedale Maggiore,; University of Milan, Milan, Italy.
- Drug users with chronic hepatitis C virus (HCV) infection are frequently co-infected with human immunodeficiency virus-1 (HIV-1), but it is still not clear whether HIV-1 worsens the natural history of hepatitis C. To investigate this, we conducted a multicentre observational study in 163 drug addicts with histological
- Hepatitis C virus co-infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus-positive patients.
- J Viral Hepat. 2000 Jul;7(4):302-8. Unique Identifier : AIDSLINE MED/20345264
- Piroth L; Grappin M; Cuzin L; Mouton Y; Bouchard O; Raffi F; Rey D; Peyramond D; Gourdon F; Drobacheff C; Lombart ML; Lucht F; Besnier JM; Bernard L; Chavanet P; Portier H; The University Hospital of Dijon, France.
- A longitudinal study of human immunodeficiency virus (HIV)-infected individuals followed-up in 13 centres was performed to assess the influence of hepatitis C virus (HCV) on the clinical and immunological evolution of HIV-infected patients. Eight-hundred and twelve HIV-infected patients with known HIV acquisition date
- [Potentially treatable subacute forms of infection due to the HTLV-1]
- Rev Neurol. 2000 Jul 1-15;31(1):32-5. Unique Identifier : AIDSLINE MED/20404380
- Carod-Artal FJ; Melo M; Alves R; Brenner C; del Negro MC; Servicio de Neurologia, Red SARAH de Hospitales del Aparato; Locomotor, Hospital Sarah-Brasilia DF, Brasilia, Brasil.; javier@bsb.sarah.br
- INTRODUCTION: Tropical spastic paraparesis due to HTLV-I virus is diagnosed at very advanced stages, when there is spinal atrophy present and so only symptomatic treatment can be given. Early diagnosis of HTLV-I infection in unusual syndromes and the use of corticosteroids may help to slow the development of the disea
- Efficient generation of human T cells from a tissue-engineered thymic organoid [see comments]
- Unique Identifier : AIDSLINE MED/20347552
- Poznansky MC; Evans RH; Foxall RB; Olszak IT; Piascik AH; Hartman KE; Brander C; Meyer TH; Pykett MJ; Chabner KT; Kalams SA; Rosenzweig M; Scadden DT; AIDS Research Center and MGH Cancer Center, Massachusetts General; Hospital, Harvard Medical School, Boston, MA 02129, USA.
- Biocompatible inorganic matrices have been used to enhance bone repair by integrating with endogenous bone architecture. Hypothesizing that a three-dimensional framework might support reconstruction of other tissues as well, we assessed the capacity of a tantalum-coated carbon matrix to support reconstitution of funct
- HIV and women. Understand your responsibilities; reduce your risk.
- AWHONN Lifelines. 1999 Dec-2000 Jan;3(6):35-8. Unique Identifier : AIDSLINE MED/20465993
- Sinclair BP; School of Health at California State University, Dominguez Hills,; USA.
- Uneven ground. HIV in women of color.
- Adv Nurse Pract. 2000 Jan;8(1):44-8; quiz 49-50. Unique Identifier : AIDSLINE MED/20465979
- Lynch M; Pugh K; Multidisciplinary AIDS Program, Cambridge Hospital, Mass., USA.
- Spermicide disappoints [news]
- Health News. 2000 Sep;6(9):7. Unique Identifier : AIDSLINE MED/20451662
- Up-regulated perforin expression of CD8+ blood lymphocytes in generalized non-anaphylactic drug eruptions and exacerbated psoriasis.
- Eur J Dermatol. 2000 Jul-Aug;10(5):365-9. Unique Identifier : AIDSLINE MED/20342679
- Behrendt C; Gollnick H; Bonnekoh B; Department of Dermatology and Venereology, Universitatsklinik; fur Dermatologie und Venerologie, Otto-von-Guericke-University,; Leipziger Str. 44, D-39120 Magdeburg, Germany.; bernd.bonnekoh@medizin.uni-magdeburg.de
- Perforin expressed in CD8+ cytotoxic T cells is known to mediate the lysis of target cells carrying microbial as well as tumor-associated antigens, and to be involved in autoimmune and transplant reactions. The aim of the present investigation was to study the role of perforin- and CD8-expressing effector lymphocytes
- Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.
- Eur J Pharm Sci. 2000;10(4):311-22. Unique Identifier : AIDSLINE MED/20299416
- Damian F; Blaton N; Naesens L; Balzarini J; Kinget R; Augustijns P; Van den Mooter G; Laboratorium voor Farmacotechnologie en Biofarmacie, K.U. Leuven,; Campus Gasthuisberg O+N, B-3000, Leuven, Belgium.
- The purpose of this study was to prepare and characterize solid dispersions of the antiviral thiocarboxanilide UC-781 with PEG 6000 and Gelucire 44/14 with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions wa
- Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine.
- Antivir Chem Chemother. 2000 Mar;11(2):111-6. Unique Identifier : AIDSLINE MED/20277586
- McGuigan C; Bidois L; Hiouni A; Ballatore C; De Clercq E; Balzarini J; Welsh School of Pharmacy, Cardiff University, UK.; mcguigan@cardiff.ac.uk
- Some novel phosphoramidate derivatives of the nucleoside analogue stavudine have been prepared as membrane-soluble prodrugs of the bioactive free phosphate forms. Phenyl phosphates linked via nitrogen to methyl esterified amino acid analogues were stu
- Structure-activity relationship studies on potential non-nucleoside DABO-like inhibitors of HIV-1 reverse transcriptase.
- Antivir Chem Chemother. 2000 Mar;11(2):117-33. Unique Identifier : AIDSLINE MED/20277587
- Costi R; Di Santo R; Artico M; Massa S; Lavecchia A; Marceddu T; Sanna L; La Colla P; Marongiu ME; Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di; Studi Farmaceutici, Universita di Roma La Sapienza, Italy.
- Using 2,6-dichloro-4-aminopyrimidine, a number of uracil and cytosine derivatives with both arylthio and alkoxy moieties were prepared. These novel pyrimidines share chemical similarities with DABOs and HEPTs, two classes of non-nucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors (N
- N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1.
- Antivir Chem Chemother. 2000 Mar;11(2):135-40. Unique Identifier : AIDSLINE MED/20277588
- Uckun FM; Mao C; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Venkatachalam TK; Department of Virology, Parker Hughes Institute, St Paul, Minn.,; USA. Fatih_Uckun@mercury.ih.org
- The composite non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket model was used to study a number of thiourea analogues with different substitutions at the 4-phenyl position including N-[2-(4-methylphenyl)ethyl]-N -[2-(5-bromopyridyl)]-thiourea (compound HI-244), which inhibited recombinant RT bette
- Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.
- Unique Identifier : AIDSLINE MED/20277589 P
- Campiani G; Fabbrini M; Morelli E; Nacci V; Greco G; Novellino E; Maga G; Spadari S; Bergamini A; Faggioli E; Uccella I; Bolacchi F
- Extract of Prunella vulgaris spikes inhibits HIV replication at reverse transcription in vitro and can be absorbed from intestine in vivo.
- Antivir Chem Chemother. 2000 Mar;11(2):157-64. Unique Identifier : AIDSLINE MED/20277590
- Kageyama S; Kurokawa M; Shiraki K; Department of Virology, Faculty of Medicine, Toyama Medical and; Pharmaceutical University, Sugitani, Japan.; kageyama@toyama-mpu.ac.jp
- It has been reported that extracts of the spike of Prunella vulgaris (PS) exhibit anti-HIV activity at the adsorption and reverse transcription stages. In this study, the actual activity of PS in cells, kinetic analysis of the inhibitory activity of PS against HIV reverse transcriptase and the feasibility of oral admi
- Synthesis and anti-HIV activity of prodrugs derived from saquinavir and indinavir.
- Antivir Chem Chemother. 2000 Mar;11(2):97-110. Unique Identifier : AIDSLINE MED/20277585
- Farese-Di Giorgio A; Rouquayrol M; Greiner J; Aubertin AM; Vierling P; Guedj R; Laboratoire de Chimie Bio-Organique, ESA 6001 CNRS, Universite; de Nice Sophia-Antipolis, France.
- With a view to improving the pharmacological properties, safety and pharmacokinetic profiles of current protease inhibitors , the synthesis of various acyl-substituted saquinavir and indinavir prodru
- Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.
- Bioorg Med Chem Lett. 2000 May 15;10(10):1003-5. Unique Identifier : AIDSLINE MED/20300188
- Yang ZY; Xia Y; Xia P; Brossi A; Cosentino LM; Lee KH; Natural Products Laboratory, School of Pharmacy, University of; North Carolina, Chapel Hill 27599, USA.
- DCK lactam analogues were synthesized and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values of 0.00024 microM and 119,333, respectively.
- Synthesis of glycolipid analogues that disrupt binding of HIV-1 gp120 to galactosylceramide.
- Unique Identifier : AIDSLINE MED/20300190
- Weber KT; Hammache D; Fantini J; Ganem B; Department of Chemistry and Chemical Biology, Cornell University,; Ithaca, NY 14853-1301, USA.
- HIV-1 has been shown to infect CD4 negative cells by the binding of HIV gp120 to the glycolipid galactosylceramide (1) (GalCer). Several analogues of 1 were prepared to investigate the specific orientation of 1 in the membrane bilayer that is involved in gp120 binding. Interestingly, N-stearyl-1-deoxynojirimycin (8) d
- Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts.
- Carcinogenesis. 2000 Sep;21(9):1647-53. Unique Identifier : AIDSLINE MED/20419735
- Mallery SR; Pei P; Kang J; Zhu G; Ness GM; Schwendeman SP; College of Dentistry, Department of Oral and Maxillofacial; Surgery and Pathology and College of Pharmacy, Division of; Pharmaceutics, Ohio State University, Columbus, OH 43210, USA.; mallery.1@osu.edu
- AIDS-related Kaposi s sarcoma (AIDS-KS), the most prevalent HIV-associated malignancy, is a debilitating, potentially fatal disease. Currently, there is a need for development of AIDS-KS therapies that are not only well tolerated, but also capable of providing sustained remission. Preclinical assessment of pharmacolog
- AIDS-related knowledge and risks and contraceptive practices in Ghana: the early 1990s.
- Afr J Reprod Health. 2000 Apr;4(1):13-27. Unique Identifier : AIDSLINE MED/20455846
- Takyi BK; Department of Sociology, University of Akron, Ohio 44325-1905,; USA.
- HIV/AIDS in Africa is transmitted primarily through heterosexual contact. This mode of disease transmission places sexually active childbearing women at high risk of contracting the disease. In this study, data from the 1993/94 Ghana Demographic Health Survey were used to explore th
- Risk factors for HIV-1 seroprevalence among family planning clients in Dar es Salaam, Tanzania.
- Afr J Reprod Health. 2000 Apr;4(1):88-99. Unique Identifier : AIDSLINE MED/20455853
- Kapiga SH; Lyamuya EF; Vuylsteke B; Spiegelman D; Larsen U; Hunter DJ; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; skapiga@hsph.harvard.edu
- Between March and September of 1995, women receiving family planning (FP) services in three large clinics in Dar es Salaam, Tanzania were invited to participate in a cross-sectional study. Consenting women were interviewed to obtain information about HIV risk factors, and blood f
- Impact of health education program on knowledge about AIDS and HIV transmission in students of secondary schools in Buraidah city, Saudi Arabia: an exploratory study.
- East Mediterr Health J. 2000 Sep;5(5):1068-75. Unique Identifier : AIDSLINE MED/20439282
- Saleh MA; al-Ghamdi YS; al-Yahia OA; Shaqran TM; Mosa AR; Medical Education and Research Center, Saudi Arabia.
- BACKGROUND: Accurate information about acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) is important for their prevention. OBJECTIVES: This study is intended to assess knowledge on AIDS in students of secondary schools in Buraidah City and to measure the effect of a health education pro
- Regional and global data and information about HIV/AIDS.
- East Mediterr Health J. 2000 Sep;5(5):1076-8. Unique Identifier : AIDSLINE MED/20439283
- [Study of psychosocial factors in HIV infected patients in Tunisia]
- East Mediterr Health J. 2000 Sep;5(5):903-11. Unique Identifier : AIDSLINE MED/20439261
- Tiouiri H; Naddari B; Khiari G; Hajjem S; Zribi A; Hopital de Psychiatrie, Tunis, Tunisie.
- We conducted a prospective study using an anonymous questionnaire and semistructured interviews on 60 patients with HIV to assess the psychological and socioenvironmental factors that may result in risk-taking behaviour. The patients were mainly young males (mean age 33.1 +/- 7.0 years) (sex ratio 2.3) deprived in bot
- HIV/STD risk reduction interventions in prison settings.
- J Womens Health Gend Based Med. 2000 Jul-Aug;9(6):587-92. Unique Identifier : AIDSLINE MED/20414811
- Hogben M; St. Lawrence JS; Division of STD Prevention, National Center for HIV, STD, and TB; Prevention, Centers for Disease Control and Prevention, Atlanta,; GA 30333, USA.
- [Breastfeeding and HIV infection]
- Med Wieku Rozwoj. 1999 Apr-Jun;3(2):209-13. Unique Identifier : AIDSLINE MED/20364314
- Niemiec KT; Urmanska W; Kmita G; Baranska M; Banach B; Zaklad Zdrowia Rodziny IMD, Instytut Matki i Dziecka w Warszawie.
- In developing countries, the benefits of breastfeeding in relation to the child s survival outnumber the risk of transmitting HIV via the mother s milk. In these countries different actions are undertaken to reduce the risk of vertical transmission during breastfeeding. On the contrary, in the developed countries HIV
- Isolation and typing methods for the epidemiologic investigation of thermotolerant campylobacters.
- Int Microbiol. 1999 Dec;2(4):217-26. Unique Identifier : AIDSLINE MED/20399114
- Barros-Velazquez J; Jimenez A; Villa TG; Food Technology Section, Higher Technological School, University; of Santiago, Lugo, Spain.
- Thermotolerant campylobacters, C. jejuni, C. coli, C. lari and C. upsaliensis, are spiral bacteria involved in human enteric disease. The prevalence of these emerging pathogens, mainly C. jejuni and to a lesser extent C. coli, as etiologic agents of enteric disease in industrialized countries has increased over the la
- The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells.
- Drug Metab Dispos. 2000 Sep;28(9):1058-62. Unique Identifier : AIDSLINE MED/20407234
- Washington CB; Wiltshire HR; Man M; Moy T; Harris SR; Worth E; Weigl P; Liang Z; Hall D; Marriott L; Blaschke TF; Division of Clinical Pharmacology, Department of Medicine,; Stanford University School of Medicine, CA 94305-5130, USA.
- Protease inhibitors are very effective in treating patients infected with HIV. However, many drugs in this class penetrate poorly into the central nervous system (CNS) and may permit this site to be a sanctuary from which resistant virus can emerge. Previous studies have shown that the protease inhibitor saquinavir (S
- [HIV and antiretroviral therapy: in every 3rd patient a virus rebound takes place (news)]
- Dtsch Med Wochenschr. 2000 Aug 18;125(33):A10. Unique Identifier : AIDSLINE MED/20470386
- Kunde K
- [New diseases in DMW: the AIDS example, 1981-2000]
- Dtsch Med Wochenschr. 2000 Aug 18;125(33):991-2. Unique Identifier : AIDSLINE MED/20449906
- Hartmann M
- Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.
- EMBO J. 2000 Jul 3;19(13):3337-48. Unique Identifier : AIDSLINE MED/20341089
- Bellavia D; Campese AF; Alesse E; Vacca A; Felli MP; Balestri A; Stoppacciaro A; Tiveron C; Tatangelo L; Giovarelli M; Gaetano C; Ruco L; Hoffman ES; Hayday AC; Lendahl U; Frati L; Gulino A; Screpanti I; Department of Experimental Medicine and Pathology, University La; Sapienza, Roma, Italy.
- The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4(-)8(-) thymocytes and is down-regulated across the CD4(-)8(-) to CD4(+)8(+) transition, controlled by pre-T-cell receptor signaling. To determine the effects of Notch3 on t
- Efficient intracellular retrotransposition of an exogenous primate retrovirus genome.
- EMBO J. 2000 Jul 3;19(13):3436-45. Unique Identifier : AIDSLINE MED/20341099
- Heinkelein M; Pietschmann T; Jarmy G; Dressler M; Imrich H; Thurow J; Lindemann D; Bock M; Moebes A; Roy J; Herchenroder O; Rethwilm A; Institut fur Virologie und Immunbiologie, Universitat Wurzburg; and Institut fur Virologie, Medizinische Fakultat 'Carl Gustav; Carus', Technische Universitat Dresden, Gerichtsstrasse 5, 01069; Dresden, Germany.
- The foamy virus (FV) subgroup of Retroviridae reverse transcribe their RNA (pre-)genome late in the replication cycle before leaving an infected cell. We studied whether a marker gene-transducing FV vector is able to shuttle to the nucleus and integrate into host cell genomic DNA. While a potential intracellular retro
- Slowed reaction time in HIV-1-seropositive intravenous drug users without AIDS.
- Eur Neurol. 2000;44(2):72-8. Unique Identifier : AIDSLINE MED/20422556
- Ayuso-Mateos JL; Pereda M; Gomez Del Barrio A; Echevarria S; Farinas MC; Garcia-Palomo D; Department of Medicine and Psychiatry, University of Cantabria; Medical School, Santander, Spain. ayusoj@medi.unican
- One hundred and fourteen subjects with a history of intravenous drug abuse (65 subjects infected with the human immunodeficiency virus, HIV, and 49 seronegative controls) were evaluated with a reaction time (RT) test which included one measure of simple RT and three measures of complex RT. All seropositive patients we
- Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex.
- Exp Cell Res. 2000 Sep 15;259(2):398-403. Unique Identifier : AIDSLINE MED/20422581
- Agostini I; Popov S; Li J; Dubrovsky L; Hao T; Bukrinsky M; The Picower Institute for Medical Research, Manhasset, New York; 11030, USA.
- Heat-shock proteins (Hsp s) are a family of molecular chaperones that contribute to protection from environmental stress. In this report, we demonstrate that a member of this family, Hsp70, facilitates nuclear import of HIV-1 preintegration complexes (PICs). The mechanism of this activity appears to be similar to the
- Pseudomonas spp. complications in patients with HIV disease: an eight-year clinical and microbiological survey.
- Eur J Epidemiol. 2000 Feb;16(2):111-8. Unique Identifier : AIDSLINE MED/20301869
- Manfredi R; Nanetti A; Ferri M; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universitai degli Studi di Bologna, Italy.
- Two hundred and twenty-four episodes of Pseudomonas spp. complications that occurred in 179 consecutive patients with HIV infection were retrospectively reviewed. Pseudomonas spp. organisms were responsible for 11.6% of 1933 episodes of non-mycobacterial bacterial diseases (5.4% of 1072 episodes of sepsis), observed o
- HIV1 infection in extra-European students in Turin (Italy): epidemiologic pattern and risk factors.
- Eur J Epidemiol. 2000 Feb;16(2):119-21. Unique Identifier : AIDSLINE MED/20301870
- Adele B; Carla Z; Angela MR; Dipartimento di Sanita Pubblica e Microbiologia, Universita; degli Studi di Torino, Italy.
- The authors studied a population of 5634 students from various continents to determine possible correlations between risk factors and seroprevalence of HIV infection. In the African sample the seroprevalence rate was 3.5%; the age range from 19 to 30 years was most affected; prevalence differences between the sexes we
- HIV testing and retesting for men and women in Switzerland.
- Eur J Epidemiol. 2000 Feb;16(2):123-33. Unique Identifier : AIDSLINE MED/20301871
- Zwahlen M; Neuenschwander BE; Jeannin A; Dubois-Arber F; Vlahov D; Swiss Federal Office of Public Health, Division of Epidemiology; and Infectious Diseases, Bern. marcel.zwahlen@bag.admin.ch
- This study was conducted to describe voluntary HIV testing in the general population in Switzerland and to estimate yearly HIV test incidence. In 1994, a representative telephone survey of individuals aged 17 to 45 years obtained self-reported information on HIV testing. In adb
- Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT.
- Eur J Haematol. 2000 Mar;64(3):164-72. Unique Identifier : AIDSLINE MED/20450688
- Majka M; Ratajczak J; Kowalska MA; Ratajczak MZ; Department of Internal Medicine, University of Pennsylvania; School of Medicine, Philadelphia 19104, USA.
- The aim of this study was to identify pathways which are involved in signal transduction from the CXCR4 receptor stimulated by stromal derived factor-1alpha (SDF-1alpha) in human malignant hematopoietic cells and normal megakaryoblasts. First, we found that activation of CXCR4 in human T cell lines (Jurkat and ATL-2) b
- Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2').
- FEBS Lett. 2000 Sep 8;481(1):63-7. Unique Identifier : AIDSLINE MED/20442177
- Marin O; Sarno S; Boschetti M; Pagano MA; Meggio F; Ciminale V; D'Agostino DM; Pinna LA; Dipartmento di Chimica Biologica and Centro del CNR per lo Studio; delle Biomembrane, Universita delgi Studi di Padova, Padua,; Italy.
- The HIV-1 Rev transactivator is phosphorylated in vitro by protein kinase CK2 at two residues, Ser-5 and Ser-8; these sites are also phosphorylated in vivo. Here we show that the mechanism by which CK2 phosphorylates Rev is unique in several respects, notably: (i) it is fully dependent on the regulatory, beta-subunit b
- Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis.
- Unique Identifier : AIDSLINE MED/20440600
- Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR
- BACKGROUND & AIMS: Most experimental models for inflammatory bowel disease in mice are associated with production of interferon (IFN)-gamma and other proinflammatory cytokines. We hypothesized that T-helper 2 (Th2)-type cells could also contribute to the colitis and cause inflammation different than that mediated b
- Integrating mental health services into primary care for HIV-infected pregnant and non-pregnant women: Whole Life--a theoretically derived model for clinical care and outcomes assessment.
- Unique Identifier : AIDSLINE MED/20396123
- Dodds S; Blaney NT; Nuehring EM; Blakley T; Lizzotte JM; Potter JE; O'Sullivan MJ
- Poor women of color who are disproportionately both infected and affected by HIV/AIDS also face multiple lifestyle and
- [Chemokines as mediators for intercellular communication in the brain]
- Nippon Yakurigaku Zasshi. 2000 Apr;115(4):193-200. Unique Identifier : AIDSLINE MED/20335535
- Minami M; Satoh M; Department of Molecular Pharmacology, Faculty of Pharmaceutical; Sciences, Kyoto University, Japan.
- Chemokines constitute a large and still growing family of structurally-related small (8-10 kDa) cytokines that have chemotactic activity for leukocytes. Recently, some receptors for chemokines were reported to be used as a co-receptor by HIV at infection. In addition to their well-established role in inflammatory resp
- The significance of timing of FTY720 administration on the immunosuppressive effect to prolong rat skin allograft survival.
- Int J Immunopharmacol. 2000 Aug;22(8):597-602. Unique Identifier : AIDSLINE MED/20445950
- Yanagawa Y; Hoshino Y; Chiba K; Tokyo Laboratories, Yoshitomi Pharmaceutical Industries Ltd.,; 3-7-25 Koyata, Iruma, 358-0026, Saitama, Japan.
- FTY720, a potent immunosuppressant, dramatically decreases the number of peripheral blood lymphocytes within a few hours after administration. The current study assessed the significance of timing of FTY720 administration on the immunosuppressive effect to prolong rat skin allograft survival (WKAH donor to F344 recipi
- Secular trends in the survival of HIV-infected homosexual men in Amsterdam and Vancouver estimated from a death-included CD4-staged Markov model.
- Int J Epidemiol. 2000 Jun;29(3):565-72. Unique Identifier : AIDSLINE MED/20330076
- Hendriks JC; Craib KJ; Veugelers PJ; van Druten HA; Coutinho RA; Schechter MT; van Griensven GJ; Department of Medical Statistics, University of Nijmegen, The; Netherlands.
- BACKGROUND: The purpose of this study was to investigate secular trends in waiting times in CD4-based stages of human immunodeficiency virus (HIV) disease progression in two cohorts of homosexual men, one in Vancouver and one in Amsterdam. All HIV-positive men with two or more CD4 counts in their AIDS-free period betw
- Predictive value of the HIV paediatric classification system for the long-term course of perinatally infected children.
- Unique Identifier : AIDSLINE MED/20330077
- Galli L; de Martino M; Tovo PA; Gabiano C; Zappa M
- BACKGROUND: To compare the Centers for Disease Control and
- 3'-Azidothymidine potently inhibits the biosynthesis of highly branched N-linked oligosaccharides and poly-N-acetyllactosamine chains in cells.
- J Biol Chem. 2000 Sep 1;275(35):26812-20. Unique Identifier : AIDSLINE MED/20418047
- Steet RA; Melancon P; Kuchta RD; Department of Chemistry and Biochemistry, University of Colorado,; Boulder, Colorado 80309-0215, USA.
- Previous studies in our laboratory have characterized 3 -azido-3 -deoxythymidine ( AZT ) as a potent inhibitor of glycosphingolipid biosynthesis in cultured cells (Steet, R., Alizadeh, M., Melancon, P., and Kuchta, R. D. (1999) Glycoconj. J. 16, 237-245
- Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation.
- J Biol Chem. 2000 Sep 1;275(35):26944-51. Unique Identifier : AIDSLINE MED/20418063
- Rigourd M; Lanchy JM; Le Grice SF; Ehresmann B; Ehresmann C; Marquet R; UPR 9002 du CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg; cedex, France.
- Initiation of human immunodeficiency virus-1 reverse transcription requires formation of a complex containing the viral RNA, primer tRNA(3)(Lys), and reverse transcriptase. Initiation, corresponding to addition of the first six nucleotides to tRNA(3)(Lys), is distinguished from elongation by its high specificity and l
- Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.
- J Biol Chem. 2000 Sep 1;275(35):27037-44. Unique Identifier : AIDSLINE MED/20418076
- Shah FS; Curr KA; Hamburgh ME; Parniak M; Mitsuya H; Arnez JG; Prasad VR; Division of Pediatric Infectious Diseases, Children's Hospital at; Montefiore, Bronx, New York 10467, USA.
- Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) variants with the K65R or L74V substitution display resistance to several nucleoside analogs. An in vitro dNTP exclusion assay revealed an increased fidelity for K65R RT compared with wild-type RT, but little change for L74V RT. When the forward mu
- Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production.
- J Neuroimmunol. 2000 Sep 1;109(1):23-9. Unique Identifier : AIDSLINE MED/20428866
- Kovalovsky D; Refojo D; Holsboer F; Arzt E; Laboratorio de Fisiologia y Biologia Molecular, Departamento de; Biologia, FCEN, Universidad de Buenos Aires, Ciudad; Universitaria, Pabellon II, (1428), Buenos Aires, Argentina.
- We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1
- Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy.
- J Neuroimmunol. 2000 Sep 1;109(1):30-3. Unique Identifier : AIDSLINE MED/20428867
- Piccinni MP; Scaletti C; Maggi E; Romagnani S; Department of Internal Medicine, Immunoallergology Unit,; University of Florence, 85 Viale Morgagni, 50134, Florence,; Italy. mppiccinni@hotmail.com
- Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2 (Th2) effectors, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. Progesterone promotes the production of IL-4 and IL-5, whereas relaxin promotes the production of IFN-gamma b
- Prolactin in autoimmunity and antitumor defence.
- J Neuroimmunol. 2000 Sep 1;109(1):47-55. Unique Identifier : AIDSLINE MED/20428870
- Matera L; Mori M; Geuna M; Buttiglieri S; Palestro G; Department of Internal Medicine, University of Turin, Corso A.M.; Dogliotti, 14. 10126, Turin, Italy. matera@molinette.unito.it
- Prolactin (PRL) enhances inflammatory and antitumor responses in vitro and thus exhibits Th1-type cytokine-like effects. Evidence from experimental models indicates that inhibition of PRL release by bromocriptine downregulates immune reactions and ameliorates autoimmune diseases in which Th1 responses are predominant.
- Use of human prolactin as a therapeutic protein to potentiate immunohematopoietic function.
- J Neuroimmunol. 2000 Sep 1;109(1):56-62. Unique Identifier : AIDSLINE MED/20428871
- Richards SM; Murphy WJ; Department of Cell and Protein Therapeutics, Genzyme Corporation,; Boston, MA, USA.
- The conclusion that prolactin plays a role in immune and hematopoietic function was initially based upon observations in hormone deficient animals. The multiple cell function defects associated with hypophysectomy or bromocriptine treatment were reversed by administration of prolactin. Since these initial observations
- Decrease of wild-type and precore mutant duck hepatitis B virus replication during lamivudine treatment in white Pekin ducks infected with the viruses.
- J Hepatol. 2000 May;32(5):850-8. Unique Identifier : AIDSLINE MED/20302297
- Tomita T; Yokosuka O; Tagawa M; Saisho H; Tamura S; Fukuda I; Omata M; First Department of Medicine, Chiba University School of; Medicine, Japan.
- BACKGROUND/AIMS: Lamivudine , an antiviral agent, has been used in the treatment of chronic hepatitis B, but little is known about its effect on intrahepatic replication of hepatitis B virus. We investigated the effect of lamivudine on the replication
- Erythroplasia of queyrat: coinfection with cutaneous carcinogenic human papillomavirus type 8 and genital papillomaviruses in a carcinoma in situ.
- J Invest Dermatol. 2000 Sep;115(3):396-401. Unique Identifier : AIDSLINE MED/20409146
- Wieland U; Jurk S; Weissenborn S; Krieg T; Pfister H; Ritzkowsky A; Institute of Virology, University of Koln, Koln, Germany.; Ulrike.Wieland@uni-koln.de
- Erythroplasia of Queyrat is a carcinoma in situ that mainly occurs on the glans penis, the prepuce, or the urethral meatus of elderly males. Up to 30% progress to squamous cell carcinoma. The cause of erythroplasia of Queyrat is largely unknown. Human papillomavirus type 16 DNA has previously been detected only in ver
- Genetic studies in systemic autoimmunity and aging.
- Immunol Res. 2000;21(2-3):111-22. Unique Identifier : AIDSLINE MED/20308948
- Kono DH; Theofilopoulos AN; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA. dkono@scripps.edu
- The etiopathogenesis of systemic lupus erythematosus remains an enigma that will probably not be solved until the genetic basis for susceptibility is defined. Through genomewide searches, we have provided a foundation for this by identifying and characterizing loci predisposing to specific disease traits in four major
- Human immunodeficiency virus type 1 hijacks host cyclophilin A for its attachment to target cells.
- Immunol Res. 2000;21(2-3):211-7. Unique Identifier : AIDSLINE MED/20308959
- Saphire AC; Bobardt MD; Gallay PA; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.
- Our laboratory has identified a new facet of human immunodeficiency virus type 1 (HIV-1) entry. We demonstrated that the incorporation of host cyclophilin A (CypA) into nascent viruses is absolutely required for HIV-1 attachment to target cells. Although CypA is initially incorporated into the interior of the virus, w
- Virus and target cell evolution in human immunodeficiency virus type 1 infection.
- Immunol Res. 2000;21(2-3):253-8. Unique Identifier : AIDSLINE MED/20308965
- Mosier DE; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA. dmosier@scripps.edu
- Human immunodeficiency virus (HIV) infection leads to a prolonged struggle between a rapidly evolving viral population and a potent immune response. In the vast majority of infected individuals, the virus wins this struggle. In my laboratory, we focus on understanding both the viral and immune factors that contribute
- Antibodies in human infectious disease.
- Immunol Res. 2000;21(2-3):265-78. Unique Identifier : AIDSLINE MED/20308967
- Parren PW; Poignard P; Ditzel HJ; Williamson RA; Burton DR; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.
- Investigation of human antibody responses to viral pathogens at the molecular level is revealing novel aspects of the interplay of viruses with the humoral immune system. In viral infection, at least two types of human antibody responses exist: a response to mature envelope on virions that is neutralizing and a respon
- [Immunosuppressive effect of CTLA-4 blockade and regulatory role of CD8 T cells in Th2-mediated humoral immune responses]
- Kokubyo Gakkai Zasshi. 2000 Jun;67(2):146-54. Unique Identifier : AIDSLINE MED/20376657
- Sakurai J; Second Department of Oral and Maxillofacial Surgery, Faculty of; Dentistry, Tokyo Medical and Dental University.
- CTLA-4 is a negative regulator for T cell activation and plays an important role in down-regulating immune responses and the maintenance of peripheral tolerance. The effect of initial treatment with anti-CTLA-4 mAb on murine acute and chronic graft-versus-host diseases (GVHD) induced by transfer of either C57BL/6 or B
- Axonal damage revealed by accumulation of beta-amyloid precursor protein in HTLV-I-associated myelopathy.
- J Neurol Sci. 2000 Jun 15;176(2):95-101. Unique Identifier : AIDSLINE MED/20392023
- Umehara F; Abe M; Koreeda Y; Izumo S; Osame M; The Third Department of Internal Medicine, Kagoshima University; School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan.; umehara@med6.kufm.kagoshima-u.ac.jp
- We investigated the localization and extent of beta-amyloid precursor protein (APP) immunoreactivity as a sensitive marker for impairment of fast axonal transport in the spinal cords of patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The results from this study show that APP, used
- Project: HIV prevention for incarcerated youth in Indiana.
- J Community Health Nurs. 2000 Fall;17(3):151-8. Unique Identifier : AIDSLINE MED/20441024
- Schlapman N; Cass PS; Division of Nursing, Indiana University, Kokomo 46904-9003, USA.; nschlapm@iuk.edu
- Both Indiana and national statistics suggest that HIV-AIDS cases continue to rise in the adolescent population. Because of environmental factors, incarcerated adolescents may be at a greater risk of exposure to HIV-AIDS. Educational programs, such as the one funded for this project, may be an important step in impacti
- Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice.
- J Nutr. 2000 Sep;130(9):2361-6. Unique Identifier : AIDSLINE MED/20416287
- Lenhard JM; Croom DK; Weiel JE; Spaltenstein A; Reynolds DJ; Furfine ES; Department of Metabolic Diseases, Glaxo Wellcome Incorporated,; Research Triangle Park, NC 27709, USA.
- Human immunodeficiency virus (HIV) protease inhibitors (PI) may alter lipid metabolism in patients with acquired immunodeficiency syndrome (AIDS). However, the influence of dietary fat on the metabolic effects of PI therapy remains unknown. AKR/J mice were fed high
- Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
- J Med Chem. 2000 Sep 7;43(18):3386-99. Unique Identifier : AIDSLINE MED/20435939
- Dorsey BD; McDonough C; McDaniel SL; Levin RB; Newton CL; Hoffman JM; Darke PL; Zugay-Murphy JA; Emini EA; Schleif WA; Olsen DB; Stahlhut MW; Rutkowski CA; Kuo LC; Lin JH; Chen IW; Michelson SR; Holloway MK; Huff JR; Vacca JP; Departments of Medicinal Chemistry, Antiviral Research, Drug; Metabolism, and Molecular Systems, Merck Research Laboratories,; West Point, Pennsylvania 19486, USA. bruce_dorsey@merck.com
- Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of acquired immune-deficiency syndrome (AIDS). However, the emergence of viral resistance, demanding treatment protocols, and adverse side effect
- Are RNA viruses adapting or merely changing?
- J Mol Evol. 2000 Jul;51(1):12-20. Unique Identifier : AIDSLINE MED/20363867
- Sala M; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, 28, rue; du Dr. Roux, 75724 Paris Cedex 15, France.
- RNA viruses and retroviruses fix substitutions approximately 1 million-fold faster than their hosts. This diversification could represent an inevitable drift under purifying selection, the majority of substitutions being phenotypically neutral. The alternative is to suppose that most fixed mutations are beneficial to
- Correlates of HIV risk-taking behaviors among African-American college students: the effect of HIV knowledge, motivation, and behavioral skills.
- J Natl Med Assoc. 2000 Aug;92(8):391-404. Unique Identifier : AIDSLINE MED/20447603
- Bazargan M; Kelly EM; Stein JA; Husaini BA; Bazargan SH; Charles R. Drew University of Medicine & Science, Los Angeles, CA; 90059, USA.
- This study identifies theoretically based predictors of condom use in a sample of 253 sexually active African-American college students recruited from two historically African-American colleges. The Information-Motivation-Behavioral (IMB) skills model of AIDS-preventive behavior was employed to delineate the roles of
- Human immunodeficiency virus type 1 nucleocapsid protein can prevent self-priming of minus-strand strong stop DNA by promoting the annealing of short oligonucleotides to hairpin sequences.
- J Virol. 2000 Oct;74(19):8785-92. Unique Identifier : AIDSLINE MED/20438071
- Driscoll MD; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702-1201, USA.
- Understanding how viral components collaborate to convert the human immunodeficiency virus type 1 genome from single-stranded RNA into double-stranded DNA is critical to the understanding of viral replication. Not only must the correct reactions be carried out, but unwanted side reactions must be avoided. After minus-
- Leader sequences downstream of the primer binding site are important for efficient replication of simian immunodeficiency virus.
- J Virol. 2000 Oct;74(19):8854-60. Unique Identifier : AIDSLINE MED/20438078
- Guan Y; Whitney JB; Diallo K; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish; General Hospital, Montreal, Quebec, Canada H3T 1E2.
- Simian immunodeficiency virus (SIV) infection of macaques is remarkably similar to that of human immunodeficiency virus type 1 (HIV-1) in humans, and the SIV-macaque system is a good model for AIDS research. We have constructed an SIV proviral DNA clone that is deleted of 97 nucleotides (nt), i.e., construct SD, at po
- Nitric oxide synthesis enhances human immunodeficiency virus replication in primary human macrophages.
- J Virol. 2000 Oct;74(19):8904-12. Unique Identifier : AIDSLINE MED/20438084
- Blond D; Raoul H; Le Grand R; Dormont D; Service de Neurovirologie, Commissariat a l'Energie Atomique,; DSV/DRM, CRSSA, Institut Paris-Sud sur les Cytokines, Fontenay; aux Roses, France.
- Macrophages are suspected to play a major role in human immunodeficiency virus (HIV) infection pathogenesis, not only by their contribution to virus dissemination and persistence in the host but also through the dysregulation of immune functions. The production of NO, a highly reactive free radical, is thought to act
- Association of human immunodeficiency virus type 1 Vif with RNA and its role in reverse transcription.
- J Virol. 2000 Oct;74(19):8938-45. Unique Identifier : AIDSLINE MED/20438088
- Dettenhofer M; Cen S; Carlson BA; Kleiman L; Yu XF; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.
- The vif gene of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication, although the functional target of Vif remains elusive. HIV-1 vif mutant virions derived from nonpermissive H9 cells displayed no significant differences in the amount, ratio, or integrity of their protein composition relati
- Effects of genital tract inflammation on human immunodeficiency virus type 1 V3 populations in blood and semen.
- Unique Identifier : AIDSLINE MED/20438089
- Ping LH; Cohen MS; Hoffman I; Vernazza P; Seillier-Moiseiwitsch F; Chakraborty H; Kazembe P; Zimba D; Maida M; Fiscus SA; Eron JJ; Swanstrom R; Nelson JA
- We have examined cell-free viral populations in the blood plasma and seminal plasma compartments of men infected with subtype C human immunodeficiency virus type 1 (HIV-1) using the V3-specific heteroduplex tracking assay (V3-HTA). We studied two cohorts of subjects who had visited either a sexually transmitted diseas
- Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transfer.
- J Virol. 2000 Oct;74(19):8980-8. Unique Identifier : AIDSLINE MED/20438093
- Guo J; Wu T; Anderson J; Kane BF; Johnson DG; Gorelick RJ; Henderson LE; Levin JG; Laboratory of Molecular Genetics, National Institute of Child; Health and Human Development, Bethesda, Maryland 20892, USA.
- The nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) has two zinc fingers, each containing the invariant metal ion binding residues CCHC. Recent reports indicate that mutations in the CCHC motifs are deleterious for reverse transcription in vivo. To identify reverse transcriptase (RT) reactions
- Characterization of a major histocompatibility complex class II X-box-binding protein enhancing tat-induced transcription directed by the human immunodeficiency virus type 1 long terminal repeat.
- J Virol. 2000 Oct;74(19):8989-9001. Unique Identifier : AIDSLINE MED/20438094
- Mischiati C; Feriotto G; Borgatti M; Giacomini P; Gambari R; Department of Biochemistry and Molecular Biology, University of; Ferrara, Ferrara, Italy. msc@unife.it
- The X-box element present within the promoter region of genes belonging to the major histocompatibility complex (MHC) plays a pivotal role in the expression of class II molecules, since it contains the binding sites for several well-characterized transcription factors. We have analyzed a randomly selected compilation
- Induction of CD8 T cells by vaccination with recombinant adenovirus expressing human papillomavirus type 16 E5 gene reduces tumor growth.
- J Virol. 2000 Oct;74(19):9083-9. Unique Identifier : AIDSLINE MED/20438105
- Liu DW; Tsao YP; Hsieh CH; Hsieh JT; Kung JT; Chiang CL; Huang SJ; Chen SL; Department of Microbiology and Immunology, National Defense; Medical Center, Taipei, Taiwan.
- The potential of the E5 protein as a tumor vaccine candidate has not been explored yet. In this study, we evaluate the human papillomavirus type 16 (HPV-16) E5 protein delivered by an adenovirus vector as a tumor vaccine for cervical lesions. The results demonstrate that a single intramuscular injection of a recombina
- Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype.
- J Virol. 2000 Oct;74(19):9144-51. Unique Identifier : AIDSLINE MED/20438112
- Betts MR; Casazza JP; Patterson BA; Waldrop S; Trigona W; Fu TM; Kern F; Picker LJ; Koup RA; Department of Internal Medicine, Division of Infectious Diseases,; The University of Texas Southwestern Medical Center, Dallas,; Texas 75390, USA.
- Recent studies of human immunodeficiency virus (HIV)-specific CD8(+) T cells have focused on responses to single, usually HLA-A2-restricted epitopes as surrogate measures of the overall response to HIV. However, the assumption that a response to one epitope is representative of the total response is unconfirmed. Here
- Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes.
- J Virol. 2000 Oct;74(19):9214-21. Unique Identifier : AIDSLINE MED/20438119
- Kutsch O; Oh J; Nath A; Benveniste EN; Department of Cell Biology, The University of Alabama at; Birmingham, Birmingham, Alabama 35294-0005, USA.
- A finding commonly observed in human immunodeficiency virus type 1 (HIV-1)-infected patients is invasion of the brain by activated T cells and infected macrophages, eventually leading to the development of neurological disorders and HIV-1-associated dementia . The recruitment of T c
- A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression.
- J Virol. 2000 Oct;74(19):9222-33. Unique Identifier : AIDSLINE MED/20438120
- Quinones-Mateu ME; Ball SC; Marozsan AJ; Torre VS; Albright JL; Vanham G; van Der Groen G; Colebunders RL; Arts EJ; Department of Medicine, Division of Infectious Diseases, Case; Western Reserve University, Cleveland, Ohio 44106, USA.
- This study was designed to examine the impact of human immunodeficiency virus type 1 (HIV-1) fitness on disease progression through the use of a dual competition/heteroduplex tracking assay (HTA). Despite numerous studies on the impact of HIV-1 diversity and HIV-specific immune response on disease progression, we stil
- Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.
- Unique Identifier : AIDSLINE MED/20438124
- Le Gall S; Buseyne F; Trocha A; Walker BD; Heard JM; Schwartz O
- The human immunodeficiency virus type 1 Nef protein alters the post-Golgi stages of major histocompatibility complex class I (MHC-I) biogenesis. Presumed mechanisms involve the disclosure of a cryptic tyrosine-based sorting signal (YSQA) located in the cytoplasmic tail of HLA-A and -B heavy chains. We changed this sig
- Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells.
- J Virol. 2000 Oct;74(19):9306-12. Unique Identifier : AIDSLINE MED/20438129
- Samri A; Haas G; Duntze J; Bouley JM; Calvez V; Katlama C; Autran B; Laboratoire d'Immunologie Cellulaire et Tissulaire, UMR CNRS; 7627, France.
- The impact of drug resistance mutations induced by nucleoside reverse transcriptase (RT) inhibitors (NRTI) on cytotoxic T-lymphocyte (CTL) recognition of human immunodeficiency virus type 1 strain LAI (HIV-1(LAI)) RT was addressed in 35 treated or untreated patients. Two HIV-1(LAI) RT regions encompassing mutation M41
- Combination of CCR5 and CXCR4 inhibitors in therapy of human immunodeficiency virus type 1 infection: in vitro studies of mixed virus infections.
- J Virol. 2000 Oct;74(19):9328-32. Unique Identifier : AIDSLINE GENBANK/AF234235
- Rusconi S; La Seta Catamancio S; Citterio P; Bulgheroni E; Croce F; Herrmann SH; Offord RE; Galli M; Hirsch MS; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Milan, Italy.; rusconi@mailserver.unimi.it
- We studied the combined anti-human immunodeficiency virus type 1 (HIV-1) effects of a derivative of stroma-derived factor 1beta (SDF-1beta), Met-SDF-1beta, and a modified form of RANTES, aminooxypentane (AOP)-RANTES. The antiviral agents were tested singly or in combination at 95 and 99% virus inhibitory concentration
- From the Centers of Disease Control and Prevention. CDC statement on study results of product containing nonoxynol-9.
- JAMA. 2000 Sep 20;284(11):1376. Unique Identifier : AIDSLINE MED/20459994
- Seroprevalence of HBV, HCV and HIV infections among college going first time voluntary blood donors.
- JPMA J Pak Med Assoc. 2000 Aug;50(8):269-70. Unique Identifier : AIDSLINE MED/20447631
- Abdul Mujeeb S; Aamir K; Mehmood K; Blood Transfusion Service, Jinnah Postgraduate Medical Centre,; Karachi.
- OBJECTIVE: College going first time voluntary blood donors were tested for HBV, HCV and HIV infections, to know the seroprevalence of these diseases among them. METHOD: Blood donation camps were organized at 18 colleges and universities of the city and a total of 612 samples from first time donors were tested for HbsA
- Characterization of intracellular cytokine profile of CD4(+) T cells in peripheral blood and tumor-draining lymph nodes of patients with gastrointestinal cancer.
- Jpn J Clin Oncol. 2000 Jul;30(7):301-5. Unique Identifier : AIDSLINE MED/20460228
- Nakayama H; Kitayama J; Muto T; Nagawa H; Department of Surgery, The University of Tokyo, Japan.
- BACKGROUND: Analysis of serum cytokine levels has shown that cancer-bearing hosts have lower levels of IL-2 and IFN-gamma, suggesting that Th1-type immunity is impaired by cancer. However, the mechanisms of the Th1 dysfunction are not clearly understood. METHOD: The fr
- Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes.
- Lab Invest. 2000 Sep;80(9):1361-72. Unique Identifier : AIDSLINE MED/20458215
- Walker DH; Popov VL; Feng HM; Department of Pathology, University of Texas Medical Branch,; Galveston, USA. dwalker@utmb.edu
- A mouse model of typhus rickettsiosis that reproduces the hematogenous dissemination to the critical target organs, including brain, lungs, heart, and kidneys, primary endothelial and, to a lesser degree, macrophage intracellular rickettsial infection, and typical vascular-based lesions of louse-borne typhus and murin
- Thalidomide in the treatment of relapsed multiple myeloma.
- Mayo Clin Proc. 2000 Sep;75(9):897-901. Unique Identifier : AIDSLINE MED/20448290
- Rajkumar SV; Fonseca R; Dispenzieri A; Lacy MQ; Lust JA; Witzig TE; Kyle RA; Gertz MA; Greipp PR; Division of Hematology and Internal Medicine, Mayo Clinic,; Rochester, Minn 55905, USA.
- OBJECTIVE: To describe the efficacy of therapy with thalidomide, a drug that has antiangiogenic properties, in patients with relapsed multiple myeloma. PATIENTS AND METHODS: We studied 16 patients (median age, 64 years) who received thalidomide for relapsed myeloma at the Mayo Clinic in Rochester, Minn, between Novemb
- [Viral load and CD4+ lymphocyte count in the era of highly active antiretroviral therapy]
- Med Clin (Barc). 2000 Jun 17;115(3):118. Unique Identifier : AIDSLINE MED/20420993
- Martin JC; Fernandez P; Soriano V; Martinez P; Gonzalez-Lahoz J
- [Human papillomavirus and human immunodeficiency virus infections as risk factors for cervix cancer in women prisoners]
- Med Clin (Barc). 2000 Jun 17;115(3):81-4. Unique Identifier : AIDSLINE MED/20420985
- de Sanjose S; Valls I; Paz Canadas M; Lloveras B; Quintana MJ; Shah KV; Bosch FX; Servicio de Epidemiologia y Registro del Cancer, Institut; Catala d'Oncologia, Barcelona. s.sanjose@ico.scs.es
- BACKGROUND: The identification of high risk groups for genital human papillomavirus (HPV) infection may contribute to cervical cancer prevention. The study was designed to estimate the prevalence of HPV infection and the related risk of cervical cancer among imprisoned women. PATIENTS AND METHODS: 157 women were visit
- [Trends in the number of human immunodeficiency virus infected persons and AIDS cases in Spain: 1980-1998]
- Med Clin (Barc). 2000 Jun 17;115(3):85-9. Unique Identifier : AIDSLINE MED/20420986
- Castilla J; de la Fuente L; Centro Nacional de Epidemiologa, Instituto de Salud Carlos III,; Secretaria del Plan Nacional sobre Sida, Madrid.; jcastill@isciii.es
- BACKGROUND: To describe the trend in the number of HIV-infected persons and the number of AIDS cases in Spain between 1980 and 1998. SUBJECTS AND METHODS: The following information was used: annual incidence of AIDS taken from the National Registry, AIDS deaths taken from the same r
- [Cancer and human immunodeficiency virus in the era of combination therapy (editorial)]
- Med Clin (Barc). 2000 Jun 17;115(3):93-4. Unique Identifier : AIDSLINE MED/20420988
- Nunez M; Soriano V
- [The 21st century "AIDS" (editorial)]
- Med Clin (Barc). 2000 Jun 17;115(3):95-7. Unique Identifier : AIDSLINE MED/20420989
- Casabona i Barbara J
- [Reduced mother-to-child transmission of HIV-1 infection. Exclusive breast feeding and weaning--a possible model in developing countries?]
- Lakartidningen. 2000 Jul 12;97(28-29):3273-5. Unique Identifier : AIDSLINE MED/20451568
- Casper C; Ehrnst A; Neonatalavdelningen, Astrid Lindgrens Barnsjukhus, Stockholm.
- Antiretroviral therapy with zidovudine during pregnancy, delivery, and to the newborn in combination with Cesarean section has markedly reduced the rate of mother-to-child transmission of HIV-1 in industrialized countries. These strategies are not realistic in the less developed world. Nevertheless, short-term antiret
- [Mother-to-child transmission of HIV infections. Antiviral agents and Cesarean section reduce the risk of transmission]
- Lakartidningen. 2000 Jul 12;97(28-29):3275-9. Unique Identifier : AIDSLINE MED/20451569
- Bohlin AB; Lindgren S; Lidman K; Sonnerborg A; Barnens sjukhus. ann.britt.bohlin@klinvet.ki.se
- There has been a substantial decrease in maternal-infant transmission of HIV in many European and North American countries during the past five years, from 15-25 per cent to approximately 5%. Reasons include the prophylactic administration of zidovudine to mother and child, more effective treatment strategies leading
- [The victims and denial of AIDS in Zimbabwe. Destitute health care fights disastrous epidemics]
- Lakartidningen. 2000 Jul 12;97(28-29):3284-90. Unique Identifier : AIDSLINE MED/20451571
- Carlbom H
- A possible role of N-cadherin in thalidomide teratogenicity.
- Life Sci. 2000 Jun 16;67(4):457-61. Unique Identifier : AIDSLINE MED/20456388
- Thiele A; Thormann M; Hofmann HJ; Naumann WW; Eger K; Hauschildt S; University of Leipzig, Institute of Zoology, Germany.; shaus@rz.uni-leipzig.de
- Several experimental findings indicate that the adhesion molecule N-cadherin participates in distinct processes of embryogenesis that spatiotemporarily correlate with high sensitivity to thalidomide. Therefore, we suppose that thalidomide might interfere with N-cadherin-mediated interactions. This hypothesis is suppor
- [Health in Guinea: a model system of primary health care revisited]
- Med Trop (Mars). 2000;60(1):25-8. Unique Identifier : AIDSLINE MED/20444984
- Comolet T
- [Urogenital manifestations of HIV infection in Senegal: apropos of 10 cases (letter)]
- Med Trop (Mars). 2000;60(1):99-100. Unique Identifier : AIDSLINE MED/20445000
- Gueye SM; Fall PA; Ndoye AK; Sylla C; Ba M; Mensah A
- Fluoroquinolone-resistance in Neisseria gonorrhoeae, Hawaii, 1999, and decreased susceptibility to azithromycin in N. gonorrhoeae, Missouri, 1999.
- MMWR Morb Mortal Wkly Rep. 2000 Sep 22;49(37):833-7. Unique Identifier : AIDSLINE MED/20464828
- In 1999, 360,076 cases of gonorrhea were reported in the United States (1). Gonorrhea is a major cause of pelvic inflammatory disease, often leading to ectopic pregnancy and infertility, and it can facilitate human immunodeficiency virus (HIV) transmission (2). During the 1980s, resist
- Preventing vertical transmission of HIV infection [comment] [editorial]
- N Engl J Med. 2000 Oct 5;343(14):1036-7. Unique Identifier : AIDSLINE MED/20452489
- Peckham C; Newell ML
- A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators [see comments]
- N Engl J Med. 2000 Oct 5;343(14):982-91. Unique Identifier : AIDSLINE MED/20452482
- Lallemant M; Jourdain G; Le Coeur S; Kim S; Koetsawang S; Comeau AM; Phoolcharoen W; Essex M; McIntosh K; Vithayasai V; Epidemiologie Clinique, Sante Maternelle et Infantile et Sida,; Institut de Recherche pour le Developpement, Paris.
- BACKGROUND: The optimal duration of zidovudine administration to prevent perinatal transmission of human immunodeficiency virus type 1 (HIV-1) should be determined to facilitate its use in areas where resources are limited. METHODS: We conducted a randomized, double-blind equivalence trial of zidovudine starting in th
- Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis.
- Ophthalmologica. 2000 Sep-Oct;214(5):337-40. Unique Identifier : AIDSLINE MED/20422872
- Pramod NP; Hari R; Sudhamathi K; Ananadakannan K; Thyagarajan SP; Department of Microbiology, Dr. ALM Postgraduate Institute of; Basic Medical Sciences, University of Madras, India.
- Human immunodeficiency virus (HIV) infection is associated with a wide spectrum of systemic and ocular infectious diseases. Little is known about its association with herpes simplex keratitis (HSK) in this geographical region (South India ). A retrospective study was undertaken to an
- Major aphthous ulcer in an HIV-positive child.
- Otolaryngol Head Neck Surg. 2000 Sep;123(3):340. Unique Identifier : AIDSLINE MED/20420231
- Allen PG; Myer CM 3rd; Department of Pediatric Otolaryngology-Head and Neck Surgery,; Children's Hospital Medical Center, Cincinnati, OH 45229-3039,; USA.
- Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers.
- Nucleic Acids Res. 2000 Aug 15;28(16):3065-74. Unique Identifier : AIDSLINE MED/20392252
- Wei X; Gotte M; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish; General Hospital, 3755, chemin Cote-Ste-Catherine, Montreal,; Quebec H3T 1E2, Canada.
- Reverse transcription of human immunodeficiency virus type-1 is primed by cellular tRNA(Lys3), which is selectively packaged into viral particles where it is bound at its 3 terminus to a complementary sequence of viral RNA termed the primer binding site (PBS). Since cellular tRNA(Lys3) is highly conserved, it might c
- In vitro expansion of mammalian telomere repeats by DNA polymerase alpha-primase.
- Nucleic Acids Res. 2000 Aug 15;28(16):3117-24. Unique Identifier : AIDSLINE MED/20392258
- Nozawa K; Suzuki M; Takemura M; Yoshida S; Laboratory of Cancer Cell Biology, Research Institute for Disease; Mechanism and Control, Nagoya University School of Medicine,; Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan.
- Among the polymerases, DNA polymerase alpha-primase is involved in lagging strand DNA synthesis. A previous report indicated that DNA polymerase alpha-primase initiates primer RNA synthesis with purine bases on a single-stranded G-rich telomere repeat. In this study, we found that DNA polymerase alpha-primase precisel
- Prejudice: it's a fair cop.
- Nurs Times. 1999 Nov 10-17;95(45):12-3. Unique Identifier : AIDSLINE MED/20456045
- Coombes R
- Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis.
- Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10132-7. Unique Identifier : AIDSLINE MED/20420344
- Kurebayashi S; Ueda E; Sakaue M; Patel DD; Medvedev A; Zhang F; Jetten AM; Cell Biology Section, Laboratory of Pulmonary Pathology, National; Institute of Environmental Health Sciences, National Institutes; of Health, Research Triangle Park, NC 27709, USA.
- To identify the physiological functions of the retinoid-related orphan receptor gamma (RORgamma), a member of the nuclear receptor superfamily, mice deficient in RORgamma function were generated by targeted disruption. RORgamma(-/-) mice lack peripheral and mesenteric lymph nodes and Peyer s patches, indicating that R
- Psychological effects of HAART: a 2-year study.
- Psychosom Med. 2000 May-Jun;62(3):413-22. Unique Identifier : AIDSLINE MED/20301965
- Rabkin JG; Ferrando SJ; Lin SH; Sewell M; McElhiney M; Department of Psychiatry, Weill College of Medicine, Cornell; University, Ithaca, NY, USA. jgr1@Columbia.edu
- OBJECTIVE: The objectives of this study were to evaluate the psychological consequences of combination antiretroviral treatment in terms of mood, hope, and life satisfaction in men with symptomatic human immunodeficiency virus (HIV) infection or acquired immune deficiency syndrome and to compare those whose health imp
- Evaluation of CD30 as a marker for th2 lymphocytes in bronchoalveolar lavage in interstitial lung diseases.
- Respir Med. 2000 Apr;94(4):345-9. Unique Identifier : AIDSLINE MED/20302042
- Petkova D; Xaubet A; Picado C; Filella X; Agusti C; Luburich P; Rodriguez-Roisin R; Servei de Pneumologia i Al.lergia Respiratoria, IDIBAPS,; Universitat de Barcelona, Spain.
- Several studies have been carried out to clarify the relationship between CD30 expression and Th2 lymphocytes, although the results have been controversial. To investigate whether CD30 is a useful marker for Th2 lymphocytes in bronchoalveolar lavage (BAL) in interstitial lung diseases (ILD), we studied six control sub
- Descriptive study of human and bovine tuberculosis in Queretaro, Mexico.
- Rev Latinoam Microbiol. 2000 Jan-Mar;42(1):13-9. Unique Identifier : AIDSLINE MED/20404625
- Milian F; Sanchez LM; Toledo P; Ramirez C; Santillan MA; Instituto Nacional de Investigaciones Forestales, Agricolas y; Pecuarias, CENID-Fisiologia, Qro., Mexico.; milian1@sunserver.uaq.mx
- A 5-year retrospective study (1992-1996) to look at the situation of human tuberculosis was conducted in Queretaro, Mexico . Also, a 6-month study to determine the frequency of gross lesions in dairy cattle at slaughter, and a short experiment to evaluate the effect of sodium borate
- Frequency of Cryptococcus species and varieties in Mexico and their comparison with some Latin American countries.
- Rev Latinoam Microbiol. 2000 Jan-Mar;42(1):35-40. Unique Identifier : AIDSLINE MED/20404628
- Castanon-Olivares LR; Arreguin-Espinosa R; Ruiz-Palacios y Santos G; Lopez-Martinez R; Departamento de Microbiologia y Parasitologia, Facultad de; Medicina, UNAM, Mexico, D. F.
- Cryptococcosis frequency is increasing in Mexico. Few epidemiologic and clinical surveys exist even though 10-15% of patients with AIDS develop this mycosis. To know the situation about the prevalence and etiological agents of cryptococcosis in our country, a study including isolated Cryptococcus spp. strains took pla
- Assessment of developmental toxicity of antiretroviral drugs using a rat whole embryo culture system.
- Teratology. 2000 Aug;62(2):108-14. Unique Identifier : AIDSLINE MED/20389709
- Fujinaga M; Schulte M; Holodniy M; Department of Anesthesia, Stanford University School of Medicine,; Stanford, California 94305, USA. m.fujinaga@ic.ac.uk
- BACKGROUND: Previous guidelines for HIV-infected pregnant women have recommended zidovudine (ZDV) monotherapy during the second and third trimesters of pregnancy to prevent fetal HIV infection. New guidelines suggest that women should continue or be offered combination antiretroviral therapy (including
- Transplacental pharmacokinetics and fetal distribution of 2', 3'-didehydro-3'-deoxythymidine (d4T) and its metabolites in late-term rhesus macaques.
- Teratology. 2000 Aug;62(2):93-9. Unique Identifier : AIDSLINE MED/20389707
- Patterson TA; Binienda ZK; Newport GD; Lipe GW; Gillam MP; Slikker W Jr; Sandberg JA; Division of Neurotoxicology, National Center for Toxicological; Research/FDA, Jefferson, Arkansas 72079-9502, USA.; tucker.patterson@mail.state.ar.us
- BACKGROUND: The overall goal of human immunodeficiency virus (HIV) therapy during pregnancy is to maintain maternal health and reduce the probability of vertical transmission during gestation and delivery, while keeping toxicity risks low. Azidothymidine (
- Unexpected molecular mimicry among peptides MHC class II, blood-clotting factor X, and HIV-1 envelope glycoprotein GP120.
- Thromb Res. 2000 May 15;98(4):343-6. Unique Identifier : AIDSLINE MED/20284015
- Tishkoff GH; Hunt LT; Department of Medicine, Michigan State University, 48824, East; Lansing, MI, USA.
- Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint.
- Virus Res. 2000 Jul;68(2):161-73. Unique Identifier : AIDSLINE MED/20416371
- Elder RT; Yu M; Chen M; Edelson S; Zhao Y; Children's Memorial Institute for Education and Research,; Northwestern University Medical School, Chicago, IL, USA.
- HIV-1 Vpr induces cell cycle G2 arrest, morphological changes and cell death in human and fission yeast cells. The cellular targets for G2 arrest were expected to be the inhibitory phosphorylation sites of Cdc2, as G2 arrest correlates with hyperphosphorylation and decreased activity of Cdc2 in both human and fission
- Possible regulatory function of the Saccharomyces cerevisiae Ty1 retrotransposon core protein.
- Yeast. 2000 Jul;16(10):921-32. Unique Identifier : AIDSLINE MED/20330541
- Roth JF; Kingsman SM; Kingsman AJ; Martin-Rendon E; Retrovirus Molecular Biology Group, Department of Biochemistry,; University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
- The yeast Ty1 retrotransposon encodes proteins and RNA that assemble into virus-like particles (VLPs) as part of the life cycle of the retro-element. The Tya protein, which is equivalent to the retroviral Gag, is the major structural component of these particles. In this work, we demonstrate that Tya proteins fulfil o
- High prevalence of hepatitis C virus infection in Belgian intravenous drug users and potential role of the "cotton-filter" in transmission: the GEMT Study.
- Acta Gastroenterol Belg. 2000 Apr-Jun;63(2):147-53. Unique Identifier : AIDSLINE MED/20381502
- Denis B; Dedobbeleer M; Collet T; Petit J; Jamoulle M; Hayani A; Brenard R; Hospital St Joseph, Gilly.
- AIMS: To estimate viral seroprevalences for HCV, HBV and HIV among belgian intravenous (IVDU) and non intravenous (non-IVDU) drug users; to assess risk factors for HCV infection in IVDU; to assess feasibility of chronic hepatitis C follow-up in this population. DESIGN: Cross-sectional study. Demographic and behavioura
- Treatment of chronic hepatitis B: lamivudine.
- Acta Gastroenterol Belg. 2000 Apr-Jun;63(2):189-90. Unique Identifier : AIDSLINE MED/20381513
- Leung N; Prince of Wales Hospital, Hong Kong, China.
- New nucleoside analogues for chronic hepatitis B.
- Acta Gastroenterol Belg. 2000 Apr-Jun;63(2):191-3. Unique Identifier : AIDSLINE MED/20381514
- Schalm SW; Wolters LM; van Nunen AB; Niesters HG; de Man RA; Dept. of Hepatogastroenterology & Virology, University Hospital; Rotterdam, The Netherlands.
- The intrauterine device and its dynamics.
- Adv Contracept. 1999;15(2):119-32. Unique Identifier : AIDSLINE MED/20450700
- van Os WA; Kennemer Gasthuis, Haarlem, The Netherlands.
- In the past decade, attention has shifted from family planning (often made available through population programs) to reproductive health--a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity, in all matters related to the reproductive system and its function and
- [Choroidal tuberculoma in a patient with acquired immunodeficiency syndrome]
- Nippon Ganka Gakkai Zasshi. 2000 Jun;104(6):437-41. Unique Identifier : AIDSLINE MED/20343693
- Shimakawa M; Department of Ophthalmology, Tokyo Women's Medical University,; School of Medicine, Japan.
- BACKGROUND: In Japan , since the introduction of antituberculosis chemotherapy, the typical choroidal tuberculoma has been considered uncommon. A patient with acquired immunodeficiency syndrome (AIDS), because of the suppression of cell mediated immunity, faces the risk of tuberculou
- Longstanding presence of HIV-2 infection in Guinea-Bissau (West Africa).
- Acta Trop. 2000 Sep 18;76(2):119-24. Unique Identifier : AIDSLINE MED/20396754
- Piedade J; Venenno T; Prieto E; Albuquerque R; Esteves A; Parreira R; Canas-Ferreira WF; Unidade de Virologia, Instituto de Higiene e Medicina Tropical,; Universidade Nova de Lisboa, Portugal. jp@ihmt.unl.pt
- We have retrospectively studied the seroprevalence of the human immunodeficiency virus (HIV) in Guinea-Bissau in a sample of sera collected from the whole country in 1980. We tested a total of 1248 individuals and found 11 individuals who were seropositive for HIV-2 but there were
- Potential risks of viral infections in xenotransplantation.
- Acta Trop. 2000 Sep 18;76(2):147-58. Unique Identifier : AIDSLINE MED/20396758
- Langat DK; Mwenda JM; Institute of Primate Research, National Museums of Kenya, Karen,; Nairobi.
- The shortage of cadaveric human organs for transplantation may, be alleviated by the use of xenografts as a therapeutic option for end-stage organ failure. Successful attempts have been made to prevent rejection of xenograft tissues in humans. The potential spread of animal-derived pathogens to the xenograft recipient
- CT of bronchopericardial fistula: an unusual complication of multidrug-resistant tuberculosis in HIV infection.
- AJR Am J Roentgenol. 2000 Sep;175(3):819-20. Unique Identifier : AIDSLINE MED/20411003
- Bennett JA; Haramati LB; Department of Radiology, Albert Einstein College of Medicine and; Montefiore Medical Center, 111 E. 210th St., Bronx, NY 10467,; USA.
- Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiology.
- Am J Hum Genet. 1999 Oct;65(4):1047-53. Unique Identifier : AIDSLINE MED/20455735
- Su B; Jin L; Hu F; Xiao J; Luo J; Lu D; Zhang W; Chu J; Du R; Geng Z; Qiu X; Xue J; Tan J; O'Brien SJ; Chakraborty R; Human Genetics Center, University of Texas School of Public; Health, Houston, TX 77225, USA.
- Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3 A, can delay AIDS onset > or = 16 years after seroconversions. The protective effect of CCR2-64I is dominant, wherea
- CD8+ T lymphocytes mediate destruction of the vascular media in a model of chronic rejection.
- Am J Pathol. 2000 Sep;157(3):859-65. Unique Identifier : AIDSLINE MED/20437672
- Legare JF; Issekutz T; Lee TD; Hirsch G; Department of Surgery, Victoria General Hospital, Halifax, Nova; Scotia, Canada.
- Allograft arteriosclerosis is an important characteristic of chronic graft rejection. In allograft arteriosclerosis there is a striking loss of medial smooth muscle cells (SMCs) before the development of a concentric intimal proliferative response. In this study we evaluated the role of CD8+ T lymphocytes in this medi
- NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease.
- Am J Pathol. 2000 Sep;157(3):945-55. Unique Identifier : AIDSLINE MED/20437680
- Hesse M; Cheever AW; Jankovic D; Wynn TA; Schistosomiasis Immunology and Pathology Unit, Laboratory of; Parasitic Diseases, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.
- Mice sensitized with SCHISTOSOMA: mansoni eggs and IL-12 develop liver granulomas, on subsequent infection, which are smaller and less fibrotic than those in nonsensitized mice. The protective response is accompanied by a shift in the type-2 cytokine profile to one dominated by type-1 cytokines. The deviated response
- A biotin-conjugated substrate facilitating analysis of HIV-1 integrase activity on minigels.
- Anal Biochem. 2000 Aug 15;284(1):169-72. Unique Identifier : AIDSLINE MED/20393829
- Sayasith K; Sauve G; Yelle J; Department of Microbiology and Immunology (V-630), University of; Montreal, 2900 Edouard-Montpetit Blvd., Montreal, Quebec H3T 1J4,; Canada. sayasitk@Magellan.Umontreal.ca
- Discontinuation of Mycobacterium avium complex prophylaxis in patients with antiretroviral therapy-induced increases in CD4+ cell count. A randomized, double-blind, placebo-controlled trial. AIDS Clinical Trials Group 362 Study Team.
- Ann Intern Med. 2000 Oct 3;133(7):493-503. Unique Identifier : AIDSLINE MED/20469921
- Currier JS; Williams PL; Koletar SL; Cohn SE; Murphy RL; Heald AE; Hafner R; Bassily EL; Lederman HM; Knirsch C; Benson CA; Valdez H; Aberg JA; McCutchan JA; University of California, Los Angeles, CARE Center, 10833 LeConte; Avenue, Room BH-412 CHS, Los Angeles, CA 90095, USA.; jscurrier@mednet.ucla.edu
- BACKGROUND: Patients infected with HIV who experience increases in CD4(+) cell counts are at reduced risk for opportunistic infections. However, the safety of discontinuing prophylaxis against Mycobacterium avium complex has been uncertain. OBJECTIVE: To compare the rate of M. avium complex infection in patients with
- Population pharmacokinetics and pharmacodynamic modeling of abacavir (1592U89) from a dose-ranging, double-blind, randomized monotherapy trial with human immunodeficiency virus-infected subjects.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2052-60. Unique Identifier : AIDSLINE MED/20356903
- Weller S; Radomski KM; Lou Y; Stein DS; Worldwide Clinical Pharmacology, Glaxo Wellcome Inc., Research; Triangle Park, North Carolina 27709, USA.; sw46385@glaxowellcome.com
- Abacavir (formerly 1592U89) is a carbocyclic nucleoside analog with potent anti-human immunodeficiency virus (anti-HIV) activity when administered alone or in combination with other antiretroviral agents. The population pharmacokinetics and pharmacody
- Multiple-dose pharmacokinetics and pharmacodynamics of abacavir alone and in combination with zidovudine in human immunodeficiency virus-infected adults.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2061-7. Unique Identifier : AIDSLINE MED/20356904
- McDowell JA; Lou Y; Symonds WS; Stein DS; Worldwide Clinical Pharmacology, Glaxo Wellcome Inc., Research; Triangle Park, North Carolina 27709, USA.; JAM36914@GLAXOWELLCOME.COM
- Abacavir (1592U89) is a nucleoside reverse transcriptase inhibitor with potent activity against human immunodeficiency virus type 1 (HIV-1) when used alone or in combination with other antiretroviral agents. The present study was conducted to determin
- BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2093-9. Unique Identifier : AIDSLINE MED/20356909
- Robinson BS; Riccardi KA; Gong YF; Guo Q; Stock DA; Blair WS; Terry BJ; Deminie CA; Djang F; Colonno RJ; Lin PF; Department of Virology and Non-Clinical Biostatistics,; Bristol-Myers Squibb Company, Wallingford, Connecticut 06492,; USA.
- BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC(50)) of 2.6 to 5.3 nM and an EC(90) of 9 to 15 nM in cell culture. Proof-of-principle studies indicate that BMS-232632 blocks the cleavage of vi
- Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2109-17. Unique Identifier : AIDSLINE MED/20356911
- Van Vaerenbergh K; Van Laethem K; Albert J; Boucher CA; Clotet B; Floridia M; Gerstoft J; Hejdeman B; Nielsen C; Pannecouque C; Perrin L; Pirillo MF; Ruiz L; Schmit JC; Schneider F; Schoolmeester A; Schuurman R; Stellbrink HJ; Stuyver L; Van Lunzen J; Van Remoortel B; Van Wijngaerden E; Vella S; Witvrouw M; Yerly S; De Clercq E; Destmyer J; Vandamme AM; Rega Institute for Medical Research and University Hospitals,; Leuven, Belgium. Kristien.vanvaerenbergh@uz.kuleuven.ac.be
- The prevalence and the genotypic and phenotypic characteristics of multinucleoside-resistant (MNR) human immunodeficiency virus type 1 (HIV-1) variants in Europe were investigated in a multicenter study that involved centers in nine European countries. Study samples (n = 363) collected between 1991 and 1997 from patie
- A double-blind placebo-controlled crossover trial of intravenous magnesium sulfate for foscarnet-induced ionized hypocalcemia and hypomagnesemia in patients with AIDS and cytomegalovirus infection.
- Unique Identifier : AIDSLINE MED/20356916
- Huycke MM; Naguib MT; Stroemmel MM; Blick K; Monti K; Martin-Munley S; Kaufman C
- Foscarnet (trisodium phosphonoformate hexahydrate) is an antiviral agent used to treat cytomegalovirus disease in immunocompromised patients. One common side effect is acute ionized hypocalcemia and hypomagnesemia following intravenous administration. Foscarnet-induced ionized hypo
- Pharmacokinetics of single-dose oral stavudine in subjects with renal impairment and in subjects requiring hemodialysis.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2149-53. Unique Identifier : AIDSLINE MED/20356917
- Grasela DM; Stoltz RR; Barry M; Bone M; Mangold B; O'Grady P; Raymond R; Haworth SJ; Bristol-Myers Squibb, Princeton, New Jersey 08543, USA.; dennis.grasela@bms.com
- Two open-label studies assessed the pharmacokinetics of single orally administered doses of 40 mg of stavudine in subjects with renal impairment. In one study (study I), 15 subjects with selected degrees of renal impairment, but not requiring hemodial
- Effects of fluconazole and clarithromycin on rifabutin and 25-O-desacetylrifabutin pharmacokinetics.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2170-2. Unique Identifier : AIDSLINE MED/20356921
- Jordan MK; Polis MA; Kelly G; Narang PK; Masur H; Piscitelli SC; Department of Pharmacy, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland, USA.
- Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs were given together w
- Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group.
- Antimicrob Agents Chemother. 2000 Aug;44(8):2173-5. Unique Identifier : AIDSLINE MED/20356922
- Letendre SL; Capparelli EV; Ellis RJ; McCutchan JA; HIV Neurobehavioral Research Center, University of California,; San Diego, California 92103, USA. slentendre@ucsd.edu
- Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio o
- Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.
- Antiviral Res. 2000 Jul;47(1):19-28. Unique Identifier : AIDSLINE MED/20389863
- Craigo J; Callahan M; Huang RC; DeLucia AL; Department of Microbiology and Immunology, Northeastern Ohio; Universities College of Medicine, 4209 State RT 44, Rootstown, OH; 44272, USA.
- Several methylated derivatives of a plant lignan, nordihydroguaiaretic acid (NDGA) were found to be potent anti-viral agents by suppressing Sp1 regulated transcription within the sexually transmitted viruses human immunodeficiency virus (HIV) and herpes simplex virus (HSV). A prominent Sp1 DNA binding site within many
- Generalized tuberculosis in the acquired immune deficiency syndrome.
- Arch Pathol Lab Med. 2000 Sep;124(9):1267-74. Unique Identifier : AIDSLINE MED/20431694
- Smith MB; Boyars MC; Veasey S; Woods GL; Department of Pathology, University of Texas Medical Branch,; Galveston, 77555-0740, USA. mismith@utmb.edu
- OBJECTIVE: Generalized, or hematogenously disseminated, tuberculosis (TB) in patients with the acquired immune deficiency syndrome (AIDS) has been associated with a high incidence of cases remaining undiagnosed until postmortem. To better characterize generalized TB in the setting of AIDS, this report describes the cl
- Proportion positive for Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, Toxoplasma, and human immunodeficiency virus types 1 and 2 in heterophile-negative patients with an absolute lymphocytosis or an instrument-generated atypical lymphocyte flag.
- Arch Pathol Lab Med. 2000 Sep;124(9):1324-30. Unique Identifier : AIDSLINE MED/20431706
- Tsaparas YF; Brigden ML; Mathias R; Thomas E; Raboud J; Doyle PW; University of Calgary Medical School, Calgary, Alberta, Canada.
- OBJECTIVES: To determine the proportion of patients with evidence of an acute infection due to Epstein-Barr virus (EBV), cytomegalovirus ( CMV ), human herpesvirus 6 (HHV-6), Toxoplasma, or human immunodeficiency virus types 1
- The role of interleukin-13 in infectious diseases and allergy.
- Bioessays. 2000 Jul;22(7):646-56. Unique Identifier : AIDSLINE MED/20340564
- Brombacher F; University of Cape Town, Groote Schuur Hospital, Medical Faculty; Immunology Department, Cape Town, South Africa.; fbrombac@uctgsh1.uct.ac.za
- Cytokines, also referred to as interleukins, are the major orchestrators of host defence processes, and, as such, are involved in insults, repair and restoration of tissue homeostasis. This review summarises recent findings on and emerging models of the biological roles of the double-edged sword interleukin-13 (IL-13)
- Biochemical characterization of casein kinase II as a protein kinase responsible for stimulation of HIV-1 protease in vitro.
- Biochem Biophys Res Commun. 2000 Aug 28;275(2):434-9. Unique Identifier : AIDSLINE MED/20422277
- Haneda E; Furuya T; Asai S; Morikawa Y; Ohtsuki K; Laboratory of Genetical Biochemistry, Graduate School of Medical; Sciences, Kitasato University, Kitasato 1-15-1, Sagamihara,; 228-8555, Japan.
- The physiological significance of casein kinase II (CK-II) on the protease (PR) activity of recombinant HIV-1 PR (rPR) was biochemically investigated in vitro. We found that (i) the purified rPR (p11) functions as a phosphate acceptor of CK-II; (ii) the PR activity of rPR is stimulated approximately 2.9-fold after its
- Multiple myeloma with deletion of chromosome 13q is characterized by increased bone marrow neovascularization.
- Br J Haematol. 2000 Sep;110(3):605-9. Unique Identifier : AIDSLINE MED/20452801
- Schreiber S; Ackermann J; Obermair a; Kaufmann H; Urbauer E; Aletaha K; Gisslinger H; Chott a; Huber H; Drach J; First Department of Internal Medicine I, Division of Clinical; Oncology, University of Vienna, Vienna, Austria.
- Anti-angiogenesis therapy with thalidomide has been reported to have marked activity in multiple myeloma (MM). As cytogenetics is an independent prognostic factor in MM, we analysed bone marrow (BM) angiogenesis and cytogenetic abnormalities in 34 patients with active MM. BM microvessel density (MVD), as determined by
- Thalidomide therapy in refractory solid tumour patients [letter]
- Br J Haematol. 2000 Sep;110(3):754. Unique Identifier : AIDSLINE MED/20452829
- Gutheil J; Finucane D
- Increased polymorphonuclear leucocyte rigidity in HIV infected individuals.
- Br J Ophthalmol. 2000 Jul;84(7):727-31. Unique Identifier : AIDSLINE MED/20334396
- Tufail A; Holland GN; Fisher TC; Cumberland WG; Meiselman HJ; UCLA Ocular Inflammatory Disease Center, the Jules Stein Eye; Institute, and the Department of Ophthalmology, UCLA School of; Medicine, Los Angeles, CA, USA.
- AIM: Individuals with human immunodeficiency virus (HIV) infection were evaluated for evidence of abnormal polymorphonuclear leucocyte (PMN) rigidity, which can alter capillary blood flow. METHODS: The transit time of individual PMN through 8 microm pores in a cell transit analyser was used as a measure of cell rigidi
- Inhibition of human immunodeficiency virus transmission to CD4+ T cells after gene transfer of constitutively expressed interferon beta to dendritic cells.
- Hum Gene Ther. 2000 Aug 10;11(12):1695-703. Unique Identifier : AIDSLINE MED/20412950
- Cremer I; Vieillard V; Sautes-Fridman C; De Maeyer E; Laboratorie d'Immunologie Cellulaire et Clinique, INSERM U255,; Institut Curie, Paris, France. Isabelle.Cremer@curie.fr
- CD34(+)-derived dendritic cells (DCs) can be infected by the T cell-tropic HIVLAI strain, but are poorly permissive for efficient virus production. However, HIVLAI-infected DCs are able to transmit a vigorous cytopathic infection to activated CD4(+) T cells. We show that DCs differentiated from CD34(+) cells can be ef
- Transfer of interleukin-4 and interleukin-10 in patients with severe inflammatory bowel disease of the rectum.
- Hum Gene Ther. 2000 Aug 10;11(12):1731-41. Unique Identifier : AIDSLINE MED/20412954
- Rogy MA; Beinhauer BG; Reinisch W; Huang L; Pokieser P; Department of General Surgery, University of Surgery, AKH-Vienna,; Austria.
- Inflammatory bowel disease (IBD) comprises the two disorders ulcerative colitis (UC) and Crohn s disease (CD). Although the etiology is still unclear, initiation and aggravation of the inflammatory processes seem to be due to a massive local mucosal immune response. An increased number of greatly activated macrophages
- Simultaneous determination of zidovudine and lamivudine in human serum using HPLC with tandem mass spectrometry.
- J Pharm Biomed Anal. 2000 Jul;22(6):967-83. Unique Identifier : AIDSLINE MED/20313709
- Kenney KB; Wring SA; Carr RM; Wells GN; Dunn JA; Division of Bioanalysis and Drug Metabolism, Glaxo Wellcome; Research Inc, Research Triangle Park, NC 27709, USA.
- A method employing high performance liquid chromatography (HPLC) with tandem mass spectrometry (MS) has been developed and validated for the simultaneous determination of clinically relevant levels of zidovudine ( AZT ) and lamivudine (
- Collaborative inquiry with low-income Latina women.
- J Health Care Poor Underserved. 2000 Aug;11(3):326-42. Unique Identifier : AIDSLINE MED/20385767
- Flaskerud JH; Nyamathi AM; UCLA's School of Nursing 90095-1702, USA.
- Collaborative inquiry is a form of research in which researchers and participants work collaboratively as partners. The purpose of this paper is to demonstrate the process of collaborative inquiry through an example of a longitudinal, community-based study conducted over a six-year period. The research program focused
- A mixture model for longitudinal data with application to assessment of noncompliance.
- Biometrics. 2000 Jun;56(2):464-72. Unique Identifier : AIDSLINE MED/20333816
- Pauler DK; Laird NM; Biostatistics Center, Massachusetts General Hospital, Boston; 02114, USA. donna@newton.mgh.harvard.edu
- In clinical trials of a self-administered drug, repeated measures of a laboratory marker, which is affected by study medication and collected in all treatment arms, can provide valuable information on population and individual summaries of compliance. In this paper, we introduce a general finite mixture of nonlinear h
- Residuals for proportional hazards models with interval-censored survival data.
- Biometrics. 2000 Jun;56(2):473-82. Unique Identifier : AIDSLINE MED/20333817
- Farrington CP; Department of Statistics, The Open University, Milton Keynes, UK.; c.p.farrington@open.ac.uk
- We develop diagnostic tools for use with proportional hazards models for interval-censored survival data. We propose counterparts to the Cox-Snell, Lagakos (or martingale), deviance, and Schoenfeld residuals. Many of the properties of these residuals carry over to the interval-censored case. In particular, the interva
- Using conditional logistic regression to fit proportional odds models to interval censored data.
- Biometrics. 2000 Jun;56(2):511-8. Unique Identifier : AIDSLINE MED/20333822
- Rabinowitz D; Betensky RA; Tsiatis AA; Department of Statistics, Columbia University, New York, New York; 10027, USA. dan@wald.stat.columbia.edu
- An easily implemented approach to fitting the proportional odds regression model to interval-censored data is presented. The approach is based on using conditional logistic regression routines in standard statistical packages. Using conditional logistic regression allows the practitioner to sidestep complications that
- GEE with Gaussian estimation of the correlations when data are incomplete.
- Biometrics. 2000 Jun;56(2):528-36. Unique Identifier : AIDSLINE MED/20333824
- Lipsitz SR; Molenberghs G; Fitzmaurice GM; Ibrahim J; Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.; lipsitzs@musc.edu
- This paper considers a modification of generalized estimating equations (GEE) for handling missing binary response data. The proposed method uses Gaussian estimation of the correlation parameters, i.e., the estimating function that yields an estimate of the correlation parameters is obtained from the multivariate norm
- Interval estimation of the kappa coefficient with binary classification and an equal marginal probability model.
- Biometrics. 2000 Jun;56(2):583-5. Unique Identifier : AIDSLINE MED/20333831
- Nam JM; Biostatistics Branch, National Cancer Institute, Rockville,; Maryland 20892-7368, USA. namj@mail.nih.gov
- We derive a likelihood score method for interval estimation of the intraclass version of the kappa coefficient of agreement with binary classification using a general theory of Bartlett (1953, Biometrika 40, 306-317). By exact evaluation, we investigate statistical properties of the score method, the chi-square goodne
- The one-sample problem from eradication studies of chronic viral infections.
- Biometrics. 2000 Jun;56(2):626-33. Unique Identifier : AIDSLINE MED/20333838
- Cheng DM; Lagakos SW; Department of Biostatistics, Harvard University School of Public; Health, Boston, Massachusetts 02115, USA. dcheng@hsph.harvard.edu
- In studies of chronic viral infections, the objective is to estimate probabilities of developing viral eradication and resistance. Complications arise as the laboratory methods used to assess eradication status result in unusual types of censored observations. This paper proposes nonparametric methods for the one-samp
- Effects of covariate measurement error in the initial level and rate of change of an exposure variable.
- Biometrics. 2000 Jun;56(2):634-9. Unique Identifier : AIDSLINE MED/20333839
- Lyles RH; MacFarlane G; Department of Biostatistics, Rollins School of Public Health,; Emory University, Atlanta, Georgia 30322, USA.; rlyles@sph.emory.edu
- When repeated measures of an exposure variable are obtained on individuals, it can be of epidemiologic interest to relate the slope of this variable over time to a subsequent response. Subject-specific estimates of this slope are measured with error, as are corresponding estimates of the level of exposure, i.e., the i
- First Symposium of the International College of Advanced Longevity Medicine, Reno, Nevada, october 11-13, 1998.
- Nutrition. 2000 Sep;16(9):789-90. Unique Identifier : AIDSLINE MED/20462232
- Glade MJ
- Clinical use of biochemical markers of bone remodeling: current status and future directions.
- Osteoporos Int. 2000;11(6):467-80. Unique Identifier : AIDSLINE MED/20435040
- Looker AC; Bauer DC; Chesnut CH 3rd; Gundberg CM; Hochberg MC; Klee G; Kleerekoper M; Watts NB; Bell NH; National Osteoporosis Foundation, Washington, DC, USA.
- Biochemical markers of bone turnover provide a means of evaluating skeletal dynamics that complements static measurements of bone mineral density (BMD). This review evaluates the use of commercially available bone turnover markers as aids in diagnosis and monitoring response to treatment in patients with osteoporosis.
- No efficacious treatment for age-related macular degeneration.
- Bull Soc Belge Ophtalmol. 2000;276:83-92. Unique Identifier : AIDSLINE MED/20381583
- Roodhooft J; Department of Ophthalmology, Algemeen Ziekenhuis Sint-Jozef,; Turnhout, Belgium.
- PURPOSE: The purpose of this paper is to explain that many trials have been done unsuccessfully to improve age-related macular degeneration. METHODS: Different trials that have been done to improve this degeneration and that have been published in a peer reviewed journal are discussed. RESULTS: There is not yet a prev
- Dichotomy between neurokinin receptor actions in modulating allergic airway responses in an animal model of helper T cell type 2 cytokine-associated inflammation.
- Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1068-74. Unique Identifier : AIDSLINE MED/20446388
- Maghni K; Taha R; Afif W; Hamid Q; Martin JG; Meakins-Christie Laboratories, McGill University, Montreal,; Quebec, Canada.
- Neurokinins (NKs), which include substance P (SP) and neurokinin A (NKA), act through NK-1 and NK-2 receptors. There is considerable evidence of interaction between the neurogenic and the immune systems, and NKs are candidates for mediating such interactions. We hypothesized that selective inhibition of pulmonary NK-1
- Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation.
- Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1095-101. Unique Identifier : AIDSLINE MED/20446392
- Blackwell TS; Yull FE; Chen CL; Venkatakrishnan A; Blackwell TR; Hicks DJ; Lancaster LH; Christman JW; Kerr LD; Department of Medicine, Division of Allergy, Pulmonary, and; Critical Care Medicine, Departments of Microbiology and; Immunology, and Cell Biology, Vanderbilt University School of; Medicine, Nashville, USA. timothy.blackwell@mcmail.vanderbilt.edu
- We utilized a line of transgenic mice expressing Photinus luciferase complementary DNA (cDNA) under the control of a nuclear factor kappa B (NF-kappaB)-dependent promoter (from the 5 human immunodeficiency virus-1 [HIV-1] long terminal repeat) to examine the role of NF-kappaB activation in the pathogenesis of systemi
- CD8 depletion-induced late airway response is characterized by eosinophilia, increased eotaxin, and decreased IFN-gamma expression in rats.
- Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1123-31. Unique Identifier : AIDSLINE MED/20446397
- Allakhverdi Z; Lamkhioued B; Olivenstein R; Hamid Q; Renzi PM; CHUM Research Center, Notre-Dame Hospital, University of; Montreal, and Meakins-Christie Laboratories and Department of; Medicine and Pathology, McGill University, Montreal, Quebec,; Canada.
- There is an emerging body of knowledge defining the role of CD8(+) cells in the pathogenesis of allergic asthma. We have previously demonstrated in sensitized Sprague-Dawley (SD) rats that depletion of CD8(+) cells caused an increase in the late airway response (LAR) and cellular infiltration after antigen challenge.
- Infections with Mycobacterium tuberculosis and Mycobacterium avium among HIV-infected patients after the introduction of highly active antiretroviral therapy. EuroSIDA Study Group JD.
- Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):865-72. Unique Identifier : AIDSLINE MED/20446353
- Kirk O; Gatell JM; Mocroft A; Pedersen C; Proenca R; Brettle RP; Barton SE; Sudre P; Phillips AN; EuroSIDA Coordinating Centre, Department of Infectious Diseases,; Hvidovre University Hospital, Hvidovre, Denmark.; okirk@inet.uni2.dk
- The impact of highly active antiretroviral therapy (HAART) among human immunodeficiency virus (HIV)-infected patients on the incidences of mycobacterial infections has not been studied in detail. We assessed incidences of mycobacterial diseases among HIV- infected patients following the introduction of HAART, using da
- Human immunodeficiency virus type 1 infection of alveolar macrophages impairs their innate fungicidal activity.
- Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):966-70. Unique Identifier : AIDSLINE MED/20446370
- Ieong MH; Reardon CC; Levitz SM; Kornfeld H; Pulmonary Center, Evans Memorial Department of Clinical Research,; and the Department of Medicine, Boston University School of; Medicine, Boston, Massachusetts, USA.
- Impaired adaptive immunity is the hallmark of AIDS, but the effects of human immunodeficiency virus type 1 (HIV-1) infection on innate immunity are less clear. Cryptococcus neoformans (CN) is a common AIDS-related fungal pathogen acquired by inhalation. Alveolar macrophages (AM) comprise the initial host defense in cr
- Immune responses to dystropin: implications for gene therapy of Duchenne muscular dystrophy.
- Gene Ther. 2000 Sep;7(17):1439-46. Unique Identifier : AIDSLINE MED/20455001
- Ferrer A; Wells KE; Wells DJ; Department of Neuromuscular Diseases, Imperial College School of; Medicine, Charing Cross Hospital, London, UK.
- Introduction of dystrophin by gene transfer into the dystrophic muscles of Duchenne muscular dystrophy (DMD) patients has the possibility of triggering an immune response as many patients will not have been exposed to some (or all) of the epitopes of dystrophin. This could in turn lead to cytotoxic destruction of tran
- In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity.
- Gene Ther. 2000 Sep;7(17):1467-76. Unique Identifier : AIDSLINE MED/20455004
- Sun Y; Peng D; Lecanda J; Schmitz V; Barajas M; Qian C; Prieto J; Department of Internal Medicine, School of Medicine, University; of Navarra, Pamplona, Spain.
- The interaction between CD40 ligand (CD40L, CD154) and its receptor CD40 on antigen-presenting cells, is essential for the initiation of cell-mediated and humoral immune responses. In this study, we investigated the antitumor effect of in vivo gene transfer of CD40L to tumor cells using an adenoviral vector (AdCMVmCD4
- Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle.
- Gene Ther. 2000 Sep;7(17):1491-8. Unique Identifier : AIDSLINE MED/20455007
- Loser P; Hillgenberg M; Arnold W; Both GW; Hofmann C; HepaVec AG fur Gentherapie, Berlin, Germany.
- Ovine adenovirus (OAV) vectors represent a promising tool for human gene therapy since these vectors overcome the problem of pre-existing immunity against human adenovirus vectors. In this report we investigated the in vivo characteristics of this novel vector system with respect to its potential for gene transfer int
- Immunogenicity of an eight amino acid domain shared by Fas (CD95/Apo-I) and HIV-1 gp120. I. Structural and antigenic analysis.
- Mol Med. 2000 Jun;6(6):494-508. Unique Identifier : AIDSLINE MED/20425902
- Silvestris F; Cocco T; Cafforio P; Calvani N; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Italy. f.silvestris@dimo.uniba.it
- Previous studies have demonstrated that immunoglobulin G (IgG) antibodies to VEINCTR-N, a domain shared by Fas (CD95/Apo-I) and gp120, contribute to T-cell apoptosis during human immunodeficiency virus-type 1 (HIV-1) infection as a result of the agonist cross-linking of Fas. The present work was designed to determine
- VEINCTR-N, an immunogenic epitope of Fas (CD95/Apo-I), and soluble Fas enhance T-cell apoptosis in vitro. II. Functional analysis and possible implications in HIV-1 disease.
- Mol Med. 2000 Jun;6(6):509-26. Unique Identifier : AIDSLINE MED/20425903
- Silvestris F; Cafforio P; Tucci M; Del Prete A; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Italy. f.silvestris@dimo.uniba.it
- BACKGROUND: Recent studies indicate that soluble Fas (sFas) may modulate T-cell apoptosis, since it inhibits Fas-ligand (Fas-L)-mediated cytotoxicity in vitro. Here, we explored whether the soluble receptor and its major immunogenic domain, namely VEINCTR-N, interfered with apoptosis of T cells from human immunodefici
- Nitric oxide regulates MIP-1alpha expression in primary macrophages and T lymphocytes: implications for anti-HIV-1 response.
- Mol Med. 2000 Jun;6(6):542-9. Unique Identifier : AIDSLINE MED/20425905
- Sherry B; Schmidtmayerova H; Zybarth G; Dubrovsky L; Raabe T; Bukrinsky M; The Picower Institute for Medical Research, Manhasset, New York; 11030, USA.
- BACKGROUND: Chemokines and chemokine receptors have been shown to play a critical role in HIV infection. Chemokine receptors have been identified as coreceptors for viral entry into susceptible target cells, and several members of the beta chemokine subfamily of cytokines, MIP-1alpha, MIP-1beta, and RANTES, have been
- Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection [see comments]
- Nat Med. 2000 Sep;6(9):1036-42. Unique Identifier : AIDSLINE MED/20429532
- Hazenberg MD; Otto SA; Cohen Stuart JW; Verschuren MC; Borleffs JC; Boucher CA; Coutinho RA; Lange JM; Rinke de Wit TF; Tsegaye A; van Dongen JJ; Hamann D; de Boer RJ; Miedema F; Department of Clinical Viro-Immunology, CLB, and the Laboratory; for Experimental and Clinical Immunology, Academic Medical; Center, University of Amsterdam, Plesmanlaan 125, 1066CX,; Amsterdam, The Netherlands.
- Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy indi
- AIDS defined as unique military threat [news]
- Nat Med. 2000 Sep;6(9):949. Unique Identifier : AIDSLINE MED/20429503
- Dove A
- Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya.
- Nat Med. 2000 Sep;6(9):951-5. Unique Identifier : AIDSLINE MED/20429508
- Hanke T; McMichael AJ; MRC Human Immunology Unit Institute of Molecular Medicine The; John Radcliffe Oxford OX3 9DS, United Kingdom.; thanke@molbiol.ox.ac.uk
- The impact of HIV on naive T-cell homeostasis [news; comment]
- Nat Med. 2000 Sep;6(9):976-7. Unique Identifier : AIDSLINE MED/20429520
- Grossman Z; Paul WE
- Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor.
- Clin Ther. 2000 May;22(5):549-72. Unique Identifier : AIDSLINE MED/20324406
- Fung HB; Kirschenbaum HL; Hameed R; Pharmacy Service, Veterans Affairs Medical Center, Bronx, New; York 10468, USA.
- OBJECTIVE: This paper reviews the pharmacologic properties and clinical usefulness of amprenavir, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor. BACKGROUND: Amprenavir , the most recent HIV-1 protease inhibitor to receive marketi
- T-cell subsets mediate graft-versus-myeloid leukemia responses via different cytotoxic mechanisms.
- Biol Blood Marrow Transplant. 2000;6(3):231-40. Unique Identifier : AIDSLINE MED/20326963
- Hsieh MH; Patterson AE; Korngold R; Kimmel Cancer Institute, Jefferson Medical College, Philadelphia,; Pennsylvania 19107, USA.
- Analysis of the cytotoxic effector mechanisms by which T-cell subsets mediate graft-versus-leukemia (GVL) activity is complicated by systems that use unfractionated T cells and leukemias that express alloantigens in addition to tumor-specific antigens. In this study, we used MMB1.10, a myeloid leukemia of C57Bl/6 (B6)
- HIV- and FIV-derived gp120 alter spatial memory, LTP, and sleep in rats.
- Neurobiol Dis. 2000 Aug;7(4):384-94. Unique Identifier : AIDSLINE MED/20423118
- Sanchez-Alavez M; Criado J; Gomez-Chavarin M; Jimenez-Anguiano A; Navarro L; Diaz-Ruiz O; Galicia O; Sanchez-Narvaez F; Murillo-Rodriguez E; Henriksen SJ; Elder JH; Prospero-Garcia O; Grupo de Neurociencias, UNAM, Mexico, D. F., Mexico.
- Human immunodeficiency virus (HIV)-associated dementia (HAD) has been detected in 20-30% of patients suffering AIDS. The envelope glycoprotein 120 (gp120) derived from HIV seems to play a critical role in the pathophysiology of this dementia. Likewise, the feline immunodeficiency v
- Thalidomide shows promise as cancer treatment [news]
- Health News. 2000 Jan;6(1):8. Unique Identifier : AIDSLINE MED/20471172
- Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
- Acta Crystallogr D Biol Crystallogr. 2000 Sep;56 ( Pt 9):1100-9. Unique Identifier : AIDSLINE PDB/1F7R
- Prasad GS; Stura EA; Elder JH; Stout CD; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, CA 92037-1093, USA. prasad@scripps.edu
- dUTP pyrophosphatase (dUTPase) cleaves the alpha-beta phosphodiester of dUTP to form pyrophosphate and dUMP, preventing incorporation of uracil into DNA and providing the substrate for thymine synthesis. Seven crystal structures of feline immunodeficiency virus (FIV) dUTPase in three crystal forms have been determined
- Antiretroviral interventions to reduce mother-to-child transmission of human immunodeficiency virus: challenges for health systems, communities and society.
- Bull World Health Organ. 2000;78(8):1036-44. Unique Identifier : AIDSLINE MED/20449740
- Baggaley R; van Praag E; Clinical Research Unit, London School of Hygiene and Tropical; Medicine, England. rbaggaley@ukonline.co.uk
- This paper examines the ethical, economic and social issues that should be considered when antiretroviral interventions are being planned to reduce mother-to-child transmission of the human immunodeficiency virus. Interventions aiming to reduce mother-to-child transmission should be concerned with the rights of both t
- Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma.
- Cancer Chemother Pharmacol. 2000;46(3):173-9. Unique Identifier : AIDSLINE MED/20471754
- Moore JD; Dezube BJ; Gill P; Zhou XJ; Acosta EP; Sommadossi JP; University of Alabama at Birmingham, 35294, USA.
- The pharmacokinetics of TNP-470 and its major metabolites were investigated in AIDS patients enrolled in a phase I dose escalation trial for the treatment of Kaposi s sarcoma. The patients received TNP-470 by 1-h intravenous infusion in dose cohorts of 10, 20, 30, 40, 50 and 70 mg/m2. The parent drug and metabolites,
- Evidences that zidovudine (AZT) could not be directly responsible for iron overload in AZT-treated patients: an in vitro study.
- Clin Chim Acta. 2000 Oct;300(1-2):119-30. Unique Identifier : AIDSLINE MED/20416168
- D'Alessandro AM; Rinaldi AC; D'Andrea G; Brisdelli F; Di Ciccio L; Di Giulio A; Oratore A; Bozzi A; Department of Biomedical Sciences and Technology, University of; L'Aquila, I-67100, L'Aquila, Italy.
- Zidovudine (3 -azido-3 -deoxythymidine or azidothymidine, AZT ) has been the first antiretroviral agent approved for clinical use, and it is still currently used in combination therapy of human immunode
- Sjogren's syndrome: autoimmune epithelitis.
- Baillieres Best Pract Res Clin Rheumatol. 2000 Mar;14(1):73-95. Unique Identifier : AIDSLINE MED/20338063
- Manoussakis MN; Moutsopoulos HM; Department of Pathophysiology, School of Medicine, National; University of Athens, Greece.
- Sjogren s syndrome (SS) is a chronic autoimmune disorder of the exocrine glands of unknown aetiology, which is typically associated with focal lymphocytic infiltrates of glandular tissues and autoantibody responses against the Ro(SSA) and La(SSB) ribonucleoproteins. In almost one-third of patients disease involves var
- Regulation of cell cycle and apoptosis by human immunodeficiency virus type 1 Vpr.
- Microbes Infect. 2000 Jul;2(9):1011-7. Unique Identifier : AIDSLINE MED/20425372
- Fukumori T; Akari H; Yoshida A; Fujita M; Koyama AH; Kagawa S; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, 770-8503, Tokushima, Japan.
- Biological effects of HIV-1 Vpr on CD4(+) cells were studied by an infection system. High-titered HIV-1 stocks pseudotyped with vesicular stomatitis virus G protein were prepared and used to inoculate into CD4(+ )T cells at high multiplicity of infection. Both cell- and virion-associated Vpr were demonstrated to arres
- Host cell-dependent replication of HIV-1 mutants with deletions in gp41 cytoplasmic tail region is independent of the function of Vif.
- Microbes Infect. 2000 Jul;2(9):1019-23. Unique Identifier : AIDSLINE MED/20484716
- Akari H; Yoshida A; Fukumori T; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima, Japan.
- Evolution of the CD8 T-cell repertoire during infections.
- Microbes Infect. 2000 Jul;2(9):1025-39. Unique Identifier : AIDSLINE MED/20425373
- Lin MY; Selin LK; Welsh RM; The Department of Pathology and Program in Immunology and; Virology, University of Massachusetts Medical School, Worcester,; Massachusetts 01655, USA.
- CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces driv
- The immune response against Helicobacter pylori--a direct linkage to the development of gastroduodenal disease.
- Microbes Infect. 2000 Jul;2(9):1073-7. Unique Identifier : AIDSLINE MED/20425377
- Ibraghimov A; Pappo J; Department of Immunology, Astra Zeneca R+D, Boston, MA 02451,; USA.
- Helicobacter pylori infects about half of the world s population. H. pylori elicits marked immune responses, but the infection is commonly life-long. Some infected individuals remain asymptomatic, while others develop significant gastroduodenal disease. We review the underlying host immune response to H. pylori which
- Experimental histoplasmosis in mice treated with anti-murine interferon-gamma antibody and in interferon-gamma gene knockout mice.
- Microbes Infect. 2000 Jul;2(9):997-1001. Unique Identifier : AIDSLINE MED/20425370
- Clemons KV; Darbonne WC; Curnutte JT; Sobel RA; Stevens DA; California Institute for Medical Research, San Jose, California; 95128, USA.
- Histoplasma capsulatum is an important fungal pathogen in immunocompromised hosts, including AIDS patients. Experimental evidence suggests interferon-gamma (IFN) plays a role in host defense against H. capsulatum. In these studies we sought to demonstrate the importance of IFN in innate resistance to systemic histopla
- Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice.
- Am J Physiol Renal Physiol. 2000 Sep;279(3):F525-31. Unique Identifier : AIDSLINE MED/20425396
- Rabb H; Daniels F; O'Donnell M; Haq M; Saba SR; Keane W; Tang WW; Department of Internal Medicine, Hennepin County Medical Center,; University of Minnesota Medical School, Minneapolis, Minnesota; 55415, USA. rabbx003@tc.umn.edu
- Mononuclear cell infiltrates are found in human renal ischemia-reperfusion injury (IRI), and peritubular T lymphocytes have been identified in experimental IRI. However, the role of T cells in the pathogenesis of renal IRI is unknown. We hypothesized that T cells are one of the important mediators of renal IRI. To tes
- Novel bovine lentiviral vectors based on Jembrana disease virus.
- J Gene Med. 2000 May-Jun;2(3):176-85. Unique Identifier : AIDSLINE MED/20350761
- Metharom P; Takyar S; Xia HH; Ellem KA; Macmillan J; Shepherd RW; Wilcox GE; Wei MQ; Gene Therapy Unit, Sir Albert Sakzewski Virus Research Centre,; Royal Children's Hospital, Brisbane, Queensland, Australia.
- BACKGROUND: Safety is a concern that must be addressed prior to any clinical use of human immunodeficiency virus (HIV)-based lentiviral vectors in human patients. Unfortunately, efforts to examine the biosafety of the vectors in preclinical animal models are hampered due to the lack of animal models for HIV infection.
- The application of a lentiviral vector for gene transfer in fetal human hepatocytes.
- J Gene Med. 2000 May-Jun;2(3):186-93. Unique Identifier : AIDSLINE MED/20350762
- Zahler MH; Irani A; Malhi H; Reutens AT; Albanese C; Bouzahzah B; Joyce D; Gupta S; Pestell RG; Albert Einstein Cancer Center, Albert Einstein College of; Medicine, Bronx, NY 10461, USA.
- BACKGROUND: The applications of traditional retroviral vectors are limited because proviral integrations into the host genome require DNA synthesis. Lentiviruses are considered to be advantageous because of their ability to infect non-dividing cells. METHODS: To demonstrate the potential of lentiviral vectors, we used
- Hospital care for persons with AIDS in European-Union countries; a cross-country comparison.
- Health Care Manag Sci. 2000 Jan;3(1):1-7. Unique Identifier : AIDSLINE MED/20451524
- Postma MJ; Kornarou H; Paparizos V; Leidl RM; Tolley K; Kyriopoulos J; Jager JC; Groningen University Institute for Drug Exploration (GUIDE),; GUIDE/SFF, The Netherlands. postma.vdploeg@hetnet.nl
- This paper compares AIDS hospital care in several European-Union countries. For this purpose hospital-care utilisation studies on inpatient days and outpatient contacts were analysed in a generic approach controlling for severity stages of AIDS. Lifetime hospital-care needs for AIDS are derived, providing useful infor
- Pneumocystis pneumonia: miles to go [comment] [editorial]
- Chest. 2000 Sep;118(3):575-7. Unique Identifier : AIDSLINE MED/20445813
- Masur H; Shelhamer JH
- Management and outcome patterns for adult Pneumocystis carinii pneumonia, 1985 to 1995: comparison of HIV-associated cases to other immunocompromised states [see comments]
- Chest. 2000 Sep;118(3):704-11. Unique Identifier : AIDSLINE MED/20445832
- Mansharamani NG; Garland R; Delaney D; Koziel H; Division of Pulmonary and Critical Care Medicine, Department of; Medicine, Beth Israel Deaconess Medical Center and Harvard; Medical School, Boston, MA 02215, USA.
- STUDY OBJECTIVES: Encompassing periods preceding and following major advances in the diagnosis and management of HIV-related Pneumocystis carinii pneumonia (PCP), the purpose of this study was to determine whether management and outcome patterns of non-HIV PCP parallel the management and outcomes of AIDS-related PCP.
- Peripheral blood CD4 + T-lymphocyte counts during Pneumocystis carinii pneumonia in immunocompromised patients without HIV infection.
- Chest. 2000 Sep;118(3):712-20. Unique Identifier : AIDSLINE MED/20445833
- Mansharamani NG; Balachandran D; Vernovsky I; Garland R; Koziel H; Division of Pulmonary and Critical Care Medicine, Department of; Medicine, Beth Israel Deaconess Medical Center, and Harvard; Medical School, Boston 02215, USA.
- STUDY OBJECTIVES: To assess the potential use of peripheral blood CD4 + T-lymphocyte counts (CD4 + counts) as a clinically useful biological marker to identify specific immunocompromised patients (without HIV infection) at high risk for Pneumocystis carinii pneumonia (PCP). DESIGN: Prospective observational study. SET
- Delayed gastric emptying in human immunodeficiency virus infection: correlation with symptoms, autonomic function, and intestinal motility.
- Dig Dis Sci. 2000 Aug;45(8):1491-9. Unique Identifier : AIDSLINE MED/20460162
- Neild PJ; Nijran KS; Yazaki E; Evans DF; Wingate DL; Jewkes R; Gazzard BG; Department of HIV Medicine and Nuclear Medicine, Chelsea and; Westminster Hospital, London, England.
- Gastric emptying may be delayed in HIV infection. We aimed to characterize the pattern of gastric emptying in HIV seropositive subjects and correlate the findings with symptoms, as well as to identify possible etiological factors. Solid gastric emptying was measured using scintigraphy in 54 HIV seropositive subjects a
- CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A.
- Eur J Immunol. 2000 Sep;30(9):2455-9. Unique Identifier : AIDSLINE MED/20462600
- D'Souza S; Denis O; Scorza T; Nzabintwali F; Verschueren H; Huygen K; The Laboratory of Mycobacterial Immunology, Pasteur Institute of; Brussels, Belgium. sdsouza@ben.vub.ac.be
- The contribution of CD8+ and CD4+ T cell-mediated effector functions against Mycobacterium tuberculosis infection elicited by i.m. vaccination with plasmid DNA encoding the immunodominant Ag85A antigen of M. tuberculosis was studied. Ag85A DNA-vaccinated beta2-microglobulin gene-deficient (beta2m-/-) mice, which lack
- Developmental regulation of TCR efficiency.
- Eur J Immunol. 2000 Sep;30(9):2472-8. Unique Identifier : AIDSLINE MED/20462603
- Dautigny N; Lucas B; INSERM U345, Institut Necker, Paris, France.
- Unresponsiveness of mature T cells to the same self-peptide/self-MHC molecule complexes with which thymocytes have reacted during positive selection results from an increase of activation thresholds during maturation. The molecular events accounting for this increase are still unknown. In mature cells, a strong correl
- CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained.
- Eur J Immunol. 2000 Sep;30(9):2479-87. Unique Identifier : AIDSLINE MED/20462604
- Lechner F; Gruener NH; Urbani S; Uggeri J; Santantonio T; Kammer AR; Cerny A; Phillips R; Ferrari C; Pape GR; Klenerman P; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, University of Oxford, GB.
- Cellular immune responses are likely to play a key role in determining the clinical outcome in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their relationship to viral clearance are poorly understood. In a previous study we have shown highly activated, multispecific cytotoxic T
- Differential requirement of perforin and IFN-gamma in CD8 T cell-mediated immune responses against B16.F10 melanoma cells expressing a viral antigen.
- Eur J Immunol. 2000 Sep;30(9):2507-15. Unique Identifier : AIDSLINE MED/20462607
- Prevost-Blondel A; Neuenhahn M; Rawiel M; Pircher H; Institute of Medical Microbiology and Hygiene, Department of; Immunology, University of Freiburg, Germany.
- Perforin-mediated lysis and secretion of IFN-gamma belong to the key effector functions of CD8 T cells. To compare the anti-tumor activity of these two mechanisms, we used B16.F10 melanoma cells (B16GP33) expressing the cytotoxic T cell epitope GP33 and T cell receptor transgenic (TCR-tg) mice specific for GP33 and de
- A single CTL clone can recognize a naturally processed HIV-1 epitope presented by two different HLA class I molecules.
- Unique Identifier : AIDSLINE MED/20462609
- Tomiyama H; Yamada N; Komatsu H; Hirayama K; Takiguchi M; Division of Viral Immunology, Center for AIDS Research, Kumamoto; University, Japan.
- Although it is known that a single peptide can be recognized by CTL restricted to two MHC class I alleles, there is no direct evidence for presentation of a single peptide by two MHC class I molecules. Furthermore, it is unclear whether such peptides are presented to the same T cell or to different T cells. Our previo
- A global appraisal of immunodominant CD8 T cell responses to Epstein-Barr virus and cytomegalovirus by bulk screening.
- Eur J Immunol. 2000 Sep;30(9):2531-9. Unique Identifier : AIDSLINE MED/20462610
- Saulquin X; Ibisch C; Peyrat MA; Scotet E; Hourmant M; Vie H; Bonneville M; Houssaint E; INSERM U463, Institut de Biologie, Nantes, France.
- Knowledge of the immunodominant responses to Epstein-Barr Virus (EBV) and human cytomegalovirus (HCMV) should help to generate cytotoxic T cell lines to these herpesviruses. Here we report on the analysis of CD8 T cell responses to EBV and HCMV in the blood of kidney transplant rec
- TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.
- Eur J Immunol. 2000 Sep;30(9):2639-49. Unique Identifier : AIDSLINE MED/20462622
- Heath VL; Murphy EE; Crain C; Tomlinson MG; O'Garra A; Department of Immunology, DNAX Research Institute, Palo Alto,; USA.
- TGF-beta plays an important role in immune regulation in vivo and affects T cell differentiation in vitro. Here we describe how TGF-beta modulates Th2 development in vitro and investigate its mechanisms of action. TGF-beta down-regulated Th2 development of naive CD4+ Mel-14high T cells derived from the DO11.10 ovalbum
- B7 co-stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination.
- Eur J Immunol. 2000 Sep;30(9):2650-9. Unique Identifier : AIDSLINE MED/20462623
- Santra S; Barouch DH; Sharpe AH; Letvin NL; Department of Medicine, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, MA 02215, USA.
- Whether B7-1 and B7-2 have distinct functions for eliciting immune responses to antigens that are presented to the immune system by intracellular and extracellular antigen processing pathways is an unresolved question. To investigate this issue we compared the humoral and cellular immune responses elicited by immunizi
- Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact.
- Eur J Immunol. 2000 Sep;30(9):2669-78. Unique Identifier : AIDSLINE MED/20462625
- Loke P; MacDonald AS; Robb A; Maizels RM; Allen JE; Institute of Cell, Animal and Population Biology, University of; Edinburg, GB.
- The cytokine microenvironment is thought to play an important role in the generation of immunoregulatory cells. Nematode infections are commonly associated with Th2 cytokines and hyporesponsive T cells. Here we show that IL-4-dependent macrophages recruited in vivo by the nematode parasite Brugia malayi actively suppr
- CD8 memory, immunodominance, and antigenic escape.
- Eur J Immunol. 2000 Sep;30(9):2704-12. Unique Identifier : AIDSLINE MED/20462630
- Wodarz D; Nowak MA; Institute for Advanced Study, Princeton, NJ 08540, USA.
- Previous theoretical work has suggested that efficient virus control or clearance requires antigen-independent persistence of memory cytotoxic T lymphocyte precursors (CTLp), and that failure to generate such memory CTLp can result in persistent infection and eventual loss of virus control. Here we use mathematical mo
- In experimental leishmaniasis deficiency of CD18 results in parasite dissemination associated with altered macrophage functions and incomplete Th1 cell response.
- Eur J Immunol. 2000 Sep;30(9):2729-40. Unique Identifier : AIDSLINE MED/20462633
- Schonlau F; Scharffetter-Kochanek K; Grabbe S; Pietz B; Sorg C; Sunderkotter C; Department of Experimental Dermatology, University of Munster,; Germany.
- We investigated experimental leishmaniasis in CD18-deficient mice. Whereas wild-type (WT) CD18-/- mice (129SV/C57BL/6) were resistant to infection, CD18-/- mice revealed increasing visceral dissemination of parasites. Unlike in other susceptible strains, infected footpads of CD18-/- mice did not ulcerate, due to an ab
- Elevated serum levels of soluble CD44 variant 6 are correlated with shorter survival in aggressive non-Hodgkin's lymphoma.
- Eur J Haematol. 2000 Sep;65(3):195-202. Unique Identifier : AIDSLINE MED/20460122
- Sasaki K; Niitsu N; First Department of Internal Medicine, Toho University School of; Medicine, Tokyo, Japan.
- A variant form of CD44 that has additional amino acids in the common protein backbone (CD44-v6) seems to play a role in the metastasis of malignancies. We measured soluble CD44-v6 (sCD44-v6) by ELISA in 201 patients with malignant lymphoma. The sCD44-v6 level was significantly elevated in patients with
- Primary care involvement in human immune deficiency virus infection-a pan-European view. The Eurosupport Study Group.
- Fam Pract. 2000 Aug;17(4):288-92. Unique Identifier : AIDSLINE MED/20393982
- Tomlinson DR; Colebunders R; Coppieters Y; Dreezen C; Andraghetti R; Fleerackers Y; Liess H; Kosmidis J; Department of Genitourinary and HIV Medicine, St Mary's Hospital,; London, UK.
- OBJECTIVE: The aim of this study was to compare the primary care experiences of human immunodeficiency virus (HIV)-positive individuals across Europe. METHODS: An anonymous self-administered questionnaire study was carried out between August 1996 and August 1997. A total of 15 HIV/AIDS treatment centres and 14 HIV sup
- [Human immunodeficiency virus (HIV) and pregnancy]
- Harefuah. 2000 Jun 1;138(11):960-5. Unique Identifier : AIDSLINE MED/20433787
- Wiser A; Pitlik S; Ben-Rafael Z; Hod M
- Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone.
- Inflammation. 2000 Aug;24(4):347-56. Unique Identifier : AIDSLINE MED/20307029
- Lindsay L; Oliver SJ; Freeman SL; Josien R; Krauss A; Kaplan G; Department of Neonatology, New York Hospital-Cornell Medical; Center, New York 10021, USA.
- The effect of high oxygen concentrations on lungs of neonatal rats was studied. In addition, some oxygen-exposed animals were treated with either dexamethasone or thalidomide. No gross histologic changes were noted in the lungs following exposure to 95% oxygen nor were there changes in the total number or the phenotyp
- The double-edged ocular immune response: the Cogan lecture.
- Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3243-8. Unique Identifier : AIDSLINE MED/20463102
- Whitcup SM; Allergan, Inc., Irvine, California 92612-1599, USA.; whitcup_scott@allergan.com
- The role of cytotoxic T lymphocytes in corneal allograft rejection.
- Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3341-7. Unique Identifier : AIDSLINE MED/20463116
- Hegde S; Niederkorn JY; Graduate Program in Immunology and. Department of Ophthalmology,; University of Texas Southwestern Medical Center, Dallas, Texas; 75390-9057, USA.
- PURPOSE: Immunologic rejection constitutes a major barrier to the success of allogeneic corneal transplants, but the specific mediators and mechanisms of graft rejection are poorly understood. Several studies have implicated cytotoxic T-lymphocyte (CTL) responses, typically associated with CD8(+) T cells, in promoting
- A novel presentation of cryptococcal infection in a renal allograft recipient.
- Ir Med J. 2000 May;93(3):82-4. Unique Identifier : AIDSLINE MED/20423563
- Abraham KA; Little MA; Casey R; Smyth E; Walshe JJ; Department of Nephrology, Beaumont Hospital, Dublin.
- The population of immunosuppressed patients is growing rapidly because of the HIV epidemic and the rapid expansion in transplant medicine. These patients may present to a variety of clinical specialties with seemingly innocuous infections. We present here the first Irish case of primary cryptococcal cellulitis. The pa
- Spinal epidural abscess in HIV positive patient masquerading as transverse myelitis.
- J Assoc Physicians India. 1999 Feb;47(2):248. Unique Identifier : AIDSLINE MED/20454351
- Rao U; Prasad S; Rajvanshi P; Gupta B; Dept of Medicine, Safdarjung Hospital, New Delhi.
- Human immunodeficiency virus infection--trends and problems [editorial; comment]
- J Assoc Physicians India. 1999 Mar;47(3):261-2. Unique Identifier : AIDSLINE MED/20454361
- Velhal GD; Bichile SK
- Epidemiological features of human immunodeficiency virus infection in rural area of western India [see comments]
- J Assoc Physicians India. 1999 Mar;47(3):263-6. Unique Identifier : AIDSLINE MED/20454362
- Redkar VE; Redkar SV; Redkar Hospital, Maharashtra.
- OBJECTIVES: To investigate epidemiological features of human immunodeficiency virus (HIV) infection first time in rural areas of Western India , Maharashtra. METHODS: Cross-sectional prospective study with relevant investigations of 290 patients, 181 males and 109 females of age grou
- Human immunodeficiency virus and abdominal tuberculosis--dual partners in a crime.
- J Assoc Physicians India. 1999 Mar;47(3):309-12. Unique Identifier : AIDSLINE MED/20454373
- Vyas K; Rathi P; Dept of Gastroenterology, LT Mun Med College, Sion, Mumbai.
- Nutrients as modulators of anergy in acquired immune deficiency syndrome.
- J Assoc Physicians India. 1999 Mar;47(3):318-25. Unique Identifier : AIDSLINE MED/20454375
- Hegde HR; Woodman RC; Sankaran K; Dept. of Paediatrics, University of Calgary, Alberta, Canada.
- Malnutrition induces a spectrum of immune abnormalities including a state of anergy in the host. This state is due to a decrease in CD4 + helper cells, diminished cytotoxic cell activity and reduction in production of lymphokines required for signal transduction. Human immunodeficiency virus (HIV), the retrovirus know
- Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells.
- J Neuroimmunol. 2000 Sep 22;109(2):112-20. Unique Identifier : AIDSLINE MED/20453326
- Storto M; de Grazia U; Battaglia G; Felli MP; Maroder M; Gulino A; Ragona G; Nicoletti F; Screpanti I; Frati L; Calogero A; I.N.M. Neuromed, Pozzilli, Italy.
- RT-PCR combined with immunoblotting showed the expression of group-I (mGlu1 and 5) and group-II (mGlu2 and 3) metabotropic glutamate receptors in whole mouse thymus, isolated thymocytes and TC-1S thymic stromal cell line. Cytofluorimetric analysis showed that mGlu-5 receptors were absent in CD4(-)/CD8(-) but present i
- Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis.
- J Neuroimmunol. 2000 Sep 22;109(2):188-96. Unique Identifier : AIDSLINE MED/20453334
- Nakajima A; Oshima H; Nohara C; Morimoto S; Yoshino S; Kobata T; Yagita H; Okumura K; Department of Joint Disease and Rheumatism, Nippon Medical; School, 113-8603, Tokyo, Japan. amnakaji@aol.com
- CD70/CD27 are cell surface molecules belonging to the TNF/TNF-receptor families. Ligation of CD27 by its ligand CD70 is thought to be important in T cell activation and T cell-B cell interaction. However, the in vivo function of these molecules during the establishment of cell-mediated immunity remains unclear. In thi
- Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity [see comments]
- J Clin Invest. 2000 Sep;106(6):R39-47. Unique Identifier : AIDSLINE MED/20453318
- Shustov A; Luzina I; Nguyen P; Papadimitriou JC; Handwerger B; Elkon KB; Via CS; Research Service, Department of Veteran Affairs Medical Center,; Baltimore, Maryland, USA.
- To determine the role of perforin-mediated cytotoxic T lymphocyte (CTL) effector function in immune regulation, we studied a well-characterized mouse model of graft-versus-host disease (GVHD). Induction of acute GVHD using perforin-deficient donor T cells (pfp-->F1) initially resulted in features of acute GVHD, e.g.,
- Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8(+) T cell recognition [see comments]
- J Clin Invest. 2000 Sep;106(6):R49-58. Unique Identifier : AIDSLINE MED/20453319
- Zhao MQ; Stoler MH; Liu AN; Wei B; Soguero C; Hahn YS; Enelow RI; Department of Medicine, The Beirne B. Carter Center for; Immunology Research, University of Virginia School of Medicine,; Charlottesville, Virginia 22908, USA.
- CD8(+) T lymphocyte responses are a critical arm of the immune response to respiratory virus infection and may play a role in the pathogenesis of interstitial lung disease. We have shown that CD8(+) T cells induce significant lung injury in the absence of virus infection by adoptive transfer into mice with alveolar ex
- A role for the alveolar epithelium in recruitment of mononuclear cells into the lung [comment]
- J Clin Invest. 2000 Sep;106(6):741-3. Unique Identifier : AIDSLINE MED/20453309
- Center DM; Pulmonary Center and Pulmonary and Critical Care Division, R-304,; Boston University Medical Center, Boston University School of; Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA.; dcenter@lung.bumc.bu.edu
- Perceptions of the benefits and costs associated with condom use and unprotected sex among late adolescent college students.
- J Adolesc. 2000 Aug;23(4):377-91. Unique Identifier : AIDSLINE MED/20396152
- Parsons JT; Halkitis PN; Bimbi D; Borkowski T; Department of Psychology, New Jersey City University, Jersey; City, NJ 07305, USA. jparsons2@njcu.edu
- To assess the differential effects of the perceived benefits and costs associated with both condom use and unprotected sex on sexual risk behaviors, data were collected from 704 ethnically diverse male and female sexually experienced late adolescent college students (aged 17-25). Perceived benefits and costs for condo
- Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibody.
- Unique Identifier : AIDSLINE MED/20432271
- Namba K; Ogasawara K; Kitaichi N; Morohashi T; Sasamoto Y; Kotake S; Matsuda H; Iwabuchi K; Iwabuchi C; Ohno S; Onoe K; Division of Immunobiology, Institute for Genetic Medicine,; Hokkaido University, Sapporo, Japan.
- We have defined a peptide K2 (ADKDVVVLTSSRTGGV) that corresponds to residues 201-216 of bovine interphotoreceptor retinoid-binding protein and induces experimental autoimmune uveoretinitis (EAU)4 in H-2Ak-carrying mice (H-2Ak mice). In this study, we attempted to ameliorate EAU in the H-2Ak mice without nonspecific su
- Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns.
- J Immunol. 2000 Sep 15;165(6):2982-6. Unique Identifier : AIDSLINE MED/20432274
- Kelly BL; Locksley RM; Howard Hughes Medical Institute and Departments of Medicine and; Microbiology/Immunology, University of California, San Francisco,; CA 93143, USA.
- The cytokines IL-4, IL-13, and IL-5 are markers for the Th2 subset of effector T cells and are often expressed together. These cytokine genes are organized within 140 kb of orthologous DNA in both mouse and human. Using IL-4-expressing CD4+ T cell clones derived from F1 mice, we identified allelic polymorphisms for ea
- The dual role of IL-2 in the generation and maintenance of CD8+ memory T cells.
- J Immunol. 2000 Sep 15;165(6):3031-6. Unique Identifier : AIDSLINE MED/20432280
- Dai Z; Konieczny BT; Lakkis FG; The Carlos and Marguerite Mason Transplantation Research Center,; Renal Division, Department of Medicine, Emory University and; Veterans Affairs Medical Center, Atlanta, GA 30033, USA.
- The mechanisms responsible for the generation and maintenance of T cell memory are unclear. In this study, we tested the role of IL-2 in allospecific CD8+ T cell memory by analyzing the long-term survival, phenotype, and functional characteristics of IL-2-replete (IL-2
- Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL.
- J Immunol. 2000 Sep 15;165(6):3088-93. Unique Identifier : AIDSLINE MED/20432288
- McAdam AJ; Gewurz BE; Farkash EA; Sharpe AH; Department of Pathology, Brigham and Women's Hospital, and; Harvard Medical School, Boston, MA 02115, USA.; ajmcadam@bics.harvard.edu
- B7-1 and B7-2 are important costimulatory molecules in the activation of T cell immunity. We have used mice made genetically deficient in either or both B7 molecules to determine the role of B7 molecules in activation of primary alloreactive CTL. The absence of either B7-1 or B7-2 did not alter generation of CTL from
- IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells.
- Unique Identifier : AIDSLINE MED/20432290 P
- Shi FD; Takeda K; Akira S; Sarvetnick N; Ljunggren HG
- The brain parenchyma is permissive for full antitumor CTL effector function, even in the absence of CD4 T cells.
- J Immunol. 2000 Sep 15;165(6):3128-35. Unique Identifier : AIDSLINE MED/20432294
- Walker PR; Calzascia T; Schnuriger V; Scamuffa N; Saas P; de Tribolet N; Dietrich PY; Laboratory of Tumor Immunology, Division of Oncology, and; Department of Neurosurgery, University Hospital Geneva, Geneva,; Switzerland. Paul.Walker@hcuge.ch
- Effective antitumor immune responses against cerebral malignancies have been demonstrated in several models, but precise cellular function of specific effector cells is poorly understood. We have explored this topic by analyzing the MHC class I-restricted T cell response elicited after implantation of HLA-CW3-transfec
- Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo.
- J Immunol. 2000 Sep 15;165(6):3136-44. Unique Identifier : AIDSLINE MED/20432295
- Smith KM; Pottage L; Thomas ER; Leishman AJ; Doig TN; Xu D; Liew FY; Garside P; Department of Immunology and Bacteriology, University of Glasgow,; Western Infirmary, Glasgow, United Kingdom.
- The relative ability of Th1 and Th2 T cells to help B cells remains controversial as do the mechanisms by which both T cell subsets provide help in vivo. Whether this help affects the clonal expansion and/or differentiation of B cells has been difficult to assess due to the low frequency of Ag-specific T and B lymphoc
- An intra-Peyer's patch gene transfer model for studying mucosal tolerance: distinct roles of B7 and IL-12 in mucosal T cell tolerance.
- J Immunol. 2000 Sep 15;165(6):3145-53. Unique Identifier : AIDSLINE MED/20432296
- Chen Y; Song K; Eck SL; Department of Molecular and Cellular Engineering, Institute for; Human Gene Therapy, and Department of Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.; yhc@mail.med.upenn.edu
- Development of mucosal immunity and tolerance requires coordinated expression of a number of genes within the mucosa-associated lymphoid tissue (MALT). To study the roles of these genes in the MALT, we have established a MALT-specific gene transfer model using replication-defective adenovirus as vector. In this model,
- Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes.
- J Immunol. 2000 Sep 15;165(6):3260-7. Unique Identifier : AIDSLINE PDB/1E28
- Maenaka K; Maenaka T; Tomiyama H; Takiguchi M; Stuart DI; Jones EY; Division of Structural Biology, Wellcome Trust Centre for Human; Genetics, University of Oxford, Headington, Oxford, United; Kingdom. kmaenaka@lab.nig.ac.uk
- The crystal structures of the human MHC class I allele HLA-B*5101 in complex with 8-mer, TAFTIPSI, and 9-mer, LPPVVAKEI, immunodominant peptide epitopes from HIV-1 have been determined by x-ray crystallography. In both complexes, the hydrogen-bonding network in the N-terminal anchor (P1) pocket is rearranged as a resu
- The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse.
- J Immunol. 2000 Sep 15;165(6):3284-92. Unique Identifier : AIDSLINE MED/20432313
- Unutmaz D; Xiang W; Sunshine MJ; Campbell J; Butcher E; Littman DR; Molecular Pathogenesis Program, Skirball Institute of; Biomolecular Medicine, New York University Medical Center, and; Howard Hughes Medical Institute, New York, NY 10016, USA.; derya.unutmaz@mcmail.vanderbilt.edu
- Chemokines play necessary and important roles in regulating the trafficking of lymphocytes to intra- or interlymphoid tissues as well as to sites of inflammation. The complex migratory patterns of lymphoid lineage cells is governed by subset-specific expression of chemokine receptors and their access to specific ligan
- Dual role of the HIV-1 vpr protein in the modulation of the apoptotic response of T cells.
- J Immunol. 2000 Sep 15;165(6):3293-300. Unique Identifier : AIDSLINE MED/20432314
- Conti L; Matarrese P; Varano B; Gauzzi MC; Sato A; Malorni W; Belardelli F; Gessani S; Laboratories ofVirology and Ultrastructures, Istituto Superiore; di Sanita, Rome, Italy; and Shionogi Institute for Medical; Science, Osaka, Japan.
- We investigated the effect of vpr, physiologically expressed during the course of an acute HIV-1 infection, on the response of infected cells to apoptotic stimuli as well as on the HIV-induced apoptosis. At 48 h after infection, Jurkat cells exhibited a lower susceptibility to undergo apoptosis with respect to uninfec
- Salmonella infection does not increase expression and activity of the high affinity IL-12 receptor.
- J Immunol. 2000 Sep 15;165(6):3324-32. Unique Identifier : AIDSLINE MED/20432318
- Elhofy A; Marriott I; Bost KL; Department of Biology, University of North Carolina, Charlotte,; NC 28223, USA.
- Expression of high affinity IL-12 receptors is required for IL-12-mediated IFN-gamma production. Activation of this pathway has been shown to be critical in generating optimal cell-mediated immunity. Therefore, increased IL-12 receptor expression might be expected in the host response after infection by an intracellul
- Mechanisms associated with thymocyte apoptosis induced by simian immunodeficiency virus.
- J Immunol. 2000 Sep 15;165(6):3461-8. Unique Identifier : AIDSLINE MED/20432335
- Rosenzweig M; Connole M; Forand-Barabasz A; Tremblay MP; Johnson RP; Lackner AA; Divisions ofImmunology and Pathology, New England Regional; Primate Research Center, Harvard Medical School, Southborough, MA; 01772, USA. michael_rosenzweig@hms.harvard.edu
- Despite considerable research, the mechanisms by which HIV disrupts thymic function remain controversial. We have described the phenotypic changes that occur in the thymus of SIV-infected macaques during acute SIV infection. In this study, we analyzed the effects of SIV infection on apoptotic pathways in thymic tissue
- Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells.
- Unique Identifier : AIDSLINE MED/20432338
- Schuler-Thurner B; Dieckmann D; Keikavoussi P; Bender A; Maczek C; Jonuleit H; Roder C; Haendle I; Leisgang W; Dunbar R; Cerundolo V; von Den Driesch P; Knop J; Brocker EB; Enk A; Kampgen E; Schuler G; Department of Dermatology, University of Erlangen-Nuremberg,; Erlangen, Germany. schuler@derma.med.uni-erlangen.de
- Dendritic cell (DC) vaccination, albeit still in an early stage, is a promising strategy to induce immunity to cancer. We explored whether DC can expand Ag-specific CD8+ T cells even in far-advanced stage IV melanoma patients. We found that three to five biweekly vaccinations of mature, monocyte-derived DC (three vacc
- Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis.
- Unique Identifier : AIDSLINE MED/20432340
- Shimizu K; Schonbeck U; Mach F; Libby P; Mitchell RN; Departments ofMedicine and Pathology, Brigham and Women's; Hospital, Harvard Medical School, Boston, MA 02115, USA.
- Although interruption of CD40-CD40L interactions via their respective mAbs yields prolonged allograft survival, the relative importance of CD40 or CD40L on donor or host cells remains unknown. Moreover, it is uncertain whether any allospecific tolerance occurring with CD40-CD40L blockade will also prevent allograft ar
- Lack of reactivation of cytomegalovirus retinitis in an AIDS patient, during and after stopping long-term cidofovir treatment: case report.
- J Chemother. 2000 Jun;12(3):258-60. Unique Identifier : AIDSLINE MED/20334034
- Papastamopoulos V; Botsis C; Paparizos VA; Kyriakis KP; Zagoraios Y; Stavrianeas NG; Athens University, Department of Dermatology, A. Sygros Hospital,; AIDS Clinic, Greece.
- The case of an AIDS patient with cytomegalovirus ( CMV ) retinitis who was treated with cidofovir for 17 consecutive months, without any adverse effect, is presented. In the context of antiretroviral therapy, cidofovir therapeu
- Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.
- J Org Chem. 2000 Jan 14;65(1):124-8. Unique Identifier : AIDSLINE MED/20276428
- Hallock YF; Sowder RC 2nd; Pannell LK; Hughes CB; Johnson DG; Gulakowski R; Cardellina JH 2nd; Boyd MR; Laboratory of Drug Discovery Research and Development,; Developmental Therapeutics Program, Division of Cancer Treatment; and Diagnosis, National Cancer Institute, Frederick, Maryland; 21702, USA.
- Four novel anti-HIV macrocyclic peptides containing 28-31 amino acid residues, named cycloviolins A-D, have been isolated from the hitherto unstudied tropical plant Leonia cymosa. Their primary structure, including amino acid composition and sequence, was determined by a combination of MALDI-TOF and FAB MS and by enzy
- Design of novel derivatives of phosphonoformate (Foscarnet) as prodrugs and antiviral agents.
- J Org Chem. 2000 Feb 25;65(4):1218-21. Unique Identifier : AIDSLINE MED/20275827
- Ferguson CG; Gorin BI; Thatcher GR; Department of Chemistry, Queen's University, Kingston, Ontario; K7L 3N6, Canada.
- Parameter on periodontitis associated with systemic conditions. American Academy of Periodontology.
- J Periodontol. 2000 May;71(5 Suppl):876-9. Unique Identifier : AIDSLINE MED/20331953
- The American Academy of Periodontology has developed the following parameter on periodontitis associated with systemic conditions. Patients affected by periodontal disease with concomitant systemic factors should be informed about the significance of the systemic condition(s) to the periodontal disease process. Patien
- In vitro and in vivo inhibition of activation induced T cell apoptosis by bucillamine.
- J Rheumatol. 2000 Jun;27(6):1358-64. Unique Identifier : AIDSLINE MED/20309094
- Okazaki H; Sato H; Kamimura T; Hirata D; Iwamoto M; Yoshio T; Mimori A; Masuyama JI; Kano S; Minota S; Division of Clinical Immunology, Jichi Medical School,; Tochigi-Ken, Japan.
- OBJECTIVE: To investigate the mechanism of autoimmune phenomena, occasionally seen in patients with rheumatoid arthritis treated with bucillamine (BUC) and D-penicillamine (D-Pen), by evaluating their effects on apoptosis of T cells induced by T cell receptor activation or dexamethasone. METHODS: In vitro apoptosis wa
- Thalidomide in the treatment of cutaneous lupus refractory to conventional therapy.
- J Rheumatol. 2000 Jun;27(6):1429-33. Unique Identifier : AIDSLINE MED/20309105
- Ordi-Ros J; Cortes F; Cucurull E; Mauri M; Bujan S; Vilardell M; Internal Medicine Department, Vall d'Hebron Hospital, Autonoma; University of Barcelona, Spain. ordiros@hg.vhebron.es
- OBJECTIVE: We describe a prospective treatment study of thalidomide in a series of 22 patients with cutaneous lupus refractory to other treatments. METHODS: From 1992 to 1998, 22 patients with cutaneous lupus (9 with discoid lupus erythematosus, 7 with subacute cutaneous lupus, 4 with profundus lupus, 2 with nonspecif
- The geographic distribution of AIDS in the United States: is there a rural epidemic?
- J Rural Health. 2000 Winter;16(1):11-9. Unique Identifier : AIDSLINE MED/20373023
- Steinberg S; Fleming P; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.; sxw2@cdc.gov
- The goal of this study was to examine where people with acquired immune deficiency syndrome (AIDS) in the United States live and the degree to which AIDS is present in rural areas. AIDS cases reported to the Centers for Disease Control and Prevention (CDC) in 1996 were categorized by m
- Human immunodeficiency virus infection in rural areas and small cities of the southeast: contributions of migration and behavior.
- J Rural Health. 2000 Winter;16(1):20-30. Unique Identifier : AIDSLINE MED/20373024
- Lansky A; Nakashima AK; Diaz T; Fann SA; Conti L; Herr M; Smith D; Karon J; Jones JL; Ward JW; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA.
- The design of education and prevention strategies to stem the spread of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) in rural areas depends on having accurate patterns of risk behavior and transmission in local areas. Interviews were conducted with people in rural areas and small c
- Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
- J Med Chem. 2000 Sep 21;43(19):3495-504. Unique Identifier : AIDSLINE MED/20457136
- Tyndall JD; Reid RC; Tyssen DP; Jardine DK; Todd B; Passmore M; March DR; Pattenden LK; Bergman DA; Alewood D; Hu SH; Alewood PF; Birch CJ; Martin JL; Fairlie DP; Centre for Drug Design and Development, The University of; Queensland, Brisbane, Queensland 4072, Australia.
- Three new peptidomimetics (1-3) have been developed with highly stable and conformationally constrained macrocyclic components that replace tripeptide segments of protease substrates. Each compound inhibits both HIV-1 protease and viral replication (HIV-1, HIV-2) at nanomolar concentrations without cytotoxicity to uni
- NF- kappa B independent suppression of endothelial vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression by inhibition of flavin binding proteins and superoxide production.
- J Mol Cell Cardiol. 2000 Aug;32(8):1499-508. Unique Identifier : AIDSLINE MED/20361940
- Tummala PE; Chen XL; Medford RM; Division of Cardiology, Emory University School of Medicine,; Atlanta, GA 30322, USA.
- Oxidation-reduction (redox) coupled mechanisms play an important role in the regulation of cell surface adhesion molecule expression. In endothelial cells membrane-bound NADH/NADPH oxidase is a significant source of intracellular superoxide (O(2)(-)) production. We explored the role of flavin containing proteins such
- Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1.
- J Virol. 2000 Oct;74(20):9339-46. Unique Identifier : AIDSLINE MED/20457193
- Garcia-Lerma JG; Gerrish PJ; Wright AC; Qari SH; Heneine W; HIV/AIDS and Retrovirology Branch, Division of AIDS, STD, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- The majority of human immunodeficiency virus type 1 (HIV-1)-infected patients treated with zidovudine ( AZT ) plus zalcitabine ( ddC ) and didanosine (ddI) develop AZT resistance mediated
- Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.
- J Virol. 2000 Oct;74(20):9353-61. Unique Identifier : AIDSLINE MED/20457195
- Bogerd HP; Wiegand HL; Yang J; Cullen BR; Howard Hughes Medical Institute and Department of Genetics, Duke; University Medical Center, Durham, North Carolina 27710, USA.
- Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor.
- Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles.
- J Virol. 2000 Oct;74(20):9381-7. Unique Identifier : AIDSLINE MED/20457198
- Wyma DJ; Kotov A; Aiken C; Department of Microbiology and Immunology, Vanderbilt University; School of Medicine, Nashville, Tennessee 37232-2363, USA.
- Assembly of infectious human immunodeficiency virus type 1 (HIV-1) virions requires incorporation of the viral envelope glycoproteins gp41 and gp120. Several lines of evidence have suggested that the cytoplasmic tail of the transmembrane glycoprotein, gp41, associates with Pr55(Gag) in infected cells to facilitate the
- Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication.
- J Virol. 2000 Oct;74(20):9388-95. Unique Identifier : AIDSLINE MED/20457199
- Goldstein S; Brown CR; Dehghani H; Lifson JD; Hirsch VM; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Rockville, Maryland 20853, USA.
- Previous studies with simian immunodeficiency virus (SIV) infection of rhesus macaques suggested that the intrinsic susceptibility of peripheral blood mononuclear cells (PBMC) to infection with SIV in vitro was predictive of relative viremia after SIV challenge. The present study was conducted to evaluate this paramet
- Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells.
- J Virol. 2000 Oct;74(20):9396-402. Unique Identifier : AIDSLINE MED/20457200
- Lama J; Ware CF; Division of Molecular Immunology, La Jolla Institute for Allergy; and Immunology, San Diego, California 92121, USA. jlama@ucsd.edu
- Human immunodeficiency virus (HIV) Nef downregulates the antigen recognition molecules major histocompatibility complex class I and CD4. Downregulation of surface CD4 by Nef relies on the ability of this viral protein to redirect the endocytic machinery to CD4. However, by redirecting the endocytic machinery, Nef may
- Vaccination with inactivated virus but not viral DNA reduces virus load following challenge with a heterologous and virulent isolate of feline immunodeficiency virus.
- J Virol. 2000 Oct;74(20):9403-11. Unique Identifier : AIDSLINE MED/20457201
- Hosie MJ; Dunsford T; Klein D; Willett BJ; Cannon C; Osborne R; Macdonald J; Spibey N; Mackay N; Jarrett O; Neil JC; Department of Veterinary Pathology, University of Glasgow; Veterinary School, Glasgow G61 1QH, United Kingdom.; m.hosie@vet.gla.ac.uk
- It has been shown that cats can be protected against infection with the prototypic Petaluma strain of feline immunodeficiency virus (FIV(PET)) using vaccines based on either inactivated virus particles or replication-defective proviral DNA. However, the utility of such vaccines in the field is uncertain, given the abs
- C3H mouse mammary tumor virus superantigen function requires a splice donor site in the envelope gene.
- J Virol. 2000 Oct;74(20):9431-40. Unique Identifier : AIDSLINE MED/20457204
- Mustafa F; Lozano M; Dudley JP; Section of Molecular Genetics and Microbiology and Institute for; Cellular and Molecular Biology, The University of Texas at; Austin, Austin, Texas 78705, USA.
- Mouse mammary tumor virus (MMTV) encodes a superantigen (Sag) that is required for efficient milk-borne transmission of virus from mothers to offspring. The mRNA used for Sag expression is controversial, and at least four different promoters (two in the long terminal repeat and two in the envelope gene) for sag mRNA h
- Rous sarcoma virus DR posttranscriptional elements use a novel RNA export pathway.
- J Virol. 2000 Oct;74(20):9507-14. Unique Identifier : AIDSLINE MED/20457212
- Paca RE; Ogert RA; Hibbert CS; Izaurralde E; Beemon KL; Department of Biology, Johns Hopkins University, Baltimore,; Maryland 21218, USA.
- Rous sarcoma virus (RSV), a simple retrovirus, needs to export unspliced viral RNA from the nucleus to the cytoplasm, circumventing the host cell restriction on cytoplasmic expression of intron-containing RNA. The cytoplasmic accumulation of full-length viral RNA is promoted by two cis-acting direct repeat (DR) elemen
- In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy.
- J Virol. 2000 Oct;74(20):9525-31. Unique Identifier : AIDSLINE MED/20457214
- Mansky LM; Department of Molecular Virology, Immunology, and Medical; Genetics, The Arthur James Cancer Hospital and Solove Research; Institute, Ohio State University Medical Center, Columbus 43210,; USA. mansky.3@osu.edu
- Several studies have indicated that the genetic diversity of human T-cell leukemia virus type 1 (HTLV-1), a virus associated with adult T-cell leukemia, is significantly lower than that of other retroviruses, including that of human immunodeficiency virus type 1 (HIV-1). To test whether HTLV-1 variation is lower than
- 3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.
- J Virol. 2000 Oct;74(20):9532-9. Unique Identifier : AIDSLINE MED/20457215
- Mansky LM; Bernard LC; Department of Molecular Virology, Immunology, and Medical; Genetics, Ohio State University Medical Center, Columbus, Ohio; 43210, USA. mansky.3@osu.edu
- How antiretroviral drug resistance influences human immunodeficiency virus type 1 (HIV-1) evolution is not clear. This study tested the hypothesis that antiretroviral drugs such as 3 -azido-3 -deoxythymidine ( AZT ) can influence the in vivo mutation ra
- Unusual distribution of mutations associated with serial bottleneck passages of human immunodeficiency virus type 1.
- J Virol. 2000 Oct;74(20):9546-52. Unique Identifier : AIDSLINE MED/20457217
- Yuste E; Lopez-Galindez C; Domingo E; Centro de Biologia Molecular "Severo Ochoa," Universidad; Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
- Repeated bottleneck passages result in fitness losses of RNA viruses. In the case of human immunodeficiency virus type 1 (HIV-1), decreases in fitness after a limited number of plaque-to-plaque transfers in MT-4 cells were very drastic. Here we report an analysis of entire genomic nucleotide sequences of four HIV-1 cl
- Cytopathicity of human immunodeficiency virus type 2 (HIV-2) in human lymphoid tissue is coreceptor dependent and comparable to that of HIV-1.
- J Virol. 2000 Oct;74(20):9594-600. Unique Identifier : AIDSLINE MED/20457223
- Schramm B; Penn ML; Palacios EH; Grant RM; Kirchhoff F; Goldsmith MA; Gladstone Institute of Virology and Immunology, University of; California San Francisco, San Francisco, California 94141-91000,; USA.
- Epidemiological studies have shown that human immunodeficiency virus type 2 (HIV-2) is markedly less pathogenic than HIV-1 in vivo. Individuals infected with HIV-2 exhibit a remarkably slow rate of disease development, and these clinical properties have been attributed presumptively to an attenuated phenotype of HIV
- Prevention of adult T-cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T-cell leukemia virus type 1 Tax-coding DNA vaccine.
- J Virol. 2000 Oct;74(20):9610-6. Unique Identifier : AIDSLINE MED/20457225
- Ohashi T; Hanabuchi S; Kato H; Tateno H; Takemura F; Tsukahara T; Koya Y; Hasegawa A; Masuda T; Kannagi M; Department of Immunotherapeutics, Tokyo Medical and Dental; University, Medical Research Division, Tokyo 113, Japan.
- Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) in infected individuals after a long incubation period. To dissect the mechanisms of the development of the disease, we have previously established a rat model of ATL-like disease which allows examination of the growth and spread of HTLV-1
- Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells.
- J Virol. 2000 Oct;74(20):9637-45. Unique Identifier : AIDSLINE MED/20457228
- Krithivas A; Young DB; Liao G; Greene D; Hayward SD; Department of Pharmacology and Molecular Sciences, Johns Hopkins; School of Medicine, Baltimore, Maryland 21231, USA.
- The human herpesvirus 8 (HHV-8) latency-associated nuclear antigen (LANA) is expressed in all latently HHV-8 infected cells and in HHV-8-associated tumors, including primary effusion lymphoma (PEL). To better understand the contribution of LANA to tumorigenesis and to the PEL phenotype, we performed a yeast two-hybrid
- Three-dimensional structure of the human herpesvirus 8 capsid.
- J Virol. 2000 Oct;74(20):9646-54. Unique Identifier : AIDSLINE MED/20457229
- Wu L; Lo P; Yu X; Stoops JK; Forghani B; Zhou ZH; Viral and Rickettsial Disease Laboratory, Division of; Communicable Disease Control, California Department of Health; Services, Berkeley, California 94720, USA.
- Human herpesvirus 8 (HHV-8), or Kaposi s sarcoma-associated herpesvirus, is a gammaherpesvirus implicated in all forms of Kaposi s sarcoma and certain lymphomas. HHV-8 has been extensively characterized, both biochemically and immunologically, since its first description in 1994. However, its three-dimensional (3D) st
- Comparison of second-strand transfer requirements and RNase H cleavages catalyzed by human immunodeficiency virus type 1 reverse transcriptase (RT) and E478Q RT.
- J Virol. 2000 Oct;74(20):9668-79. Unique Identifier : AIDSLINE MED/20457231
- Snyder CS; Roth MJ; Department of Biochemistry, University of Medicine and Dentistry; of New Jersey-Robert Wood Johnson Medical School, Piscataway, New; Jersey 08854, USA.
- Truncated tRNA-DNA mimics were examined in an in vitro assay for second-strand transfer during human immunodeficiency virus type 1 (HIV-1) reverse transcription. Strand transfer in this system requires the progressive degradation of the RNA within the 18-mer tRNA-DNA (plus-strand strong stop DNA) intermediate to produ
- Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells.
- J Virol. 2000 Oct;74(20):9717-26. Unique Identifier : AIDSLINE MED/20457236
- Patel CA; Mukhtar M; Pomerantz RJ; The Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA.
- Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) causes AIDS dementia complex (ADC) in certain infected individuals. Recent studies have suggested that patients with ADC have an increased incidence of neuronal apoptosis leading to neuronal dn
- Human immunodeficiency virus type 1 Vpr protein is incorporated into the virion in significantly smaller amounts than gag and is phosphorylated in infected cells.
- J Virol. 2000 Oct;74(20):9727-31. Unique Identifier : AIDSLINE MED/20457237
- Muller B; Tessmer U; Schubert U; Krausslich HG; Heinrich-Pette-Institut, D-20251 Hamburg, Germany.; Barbara_Mueller@med.uni-heidelberg.de
- Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) is a small accessory protein involved in the nuclear import of viral DNA and the growth arrest of host cells. Several studies have demonstrated that a significant amount of Vpr is incorporated into the virus particle via interaction with the p6 domain
- Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolate.
- J Virol. 2000 Oct;74(20):9749-54. Unique Identifier : AIDSLINE MED/20457241
- Cho MW; Lee MK; Chen CH; Matthews T; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA. mcho@nih.gov
- We have previously reported that a chimpanzee infected with a primary human immunodeficiency virus type 1 (HIV-1) isolate (HIV-1(DH12)) developed an extremely potent virus-neutralizing antibody. Immunoglobulin G purified from this animal conferred sterilizing immunity following passive transfer to macaques which were n
- Diminished primary and secondary influenza virus-specific CD8(+) T-cell responses in CD4-depleted Ig(-/-) mice.
- J Virol. 2000 Oct;74(20):9762-5. Unique Identifier : AIDSLINE MED/20457243
- Riberdy JM; Christensen JP; Branum K; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee 38105, USA.
- Optimal expansion of influenza virus nucleoprotein (D(b)NP(366))-specific CD8(+) T cells following respiratory challenge of naive Ig(-/-) &mgr;MT mice was found to require CD4(+) T-cell help, and this effect was also observed in primed animals. Absence of the CD4(+) population was consistently correlated with dimin
- Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2).
- J Virol. 2000 Oct;74(20):9771-5. Unique Identifier : AIDSLINE MED/20457245
- Otten RA; Smith DK; Adams DR; Pullium JK; Jackson E; Kim CN; Jaffe H; Janssen R; Butera S; Folks TM; Division of AIDS, STD, and TB Laboratory Research, National; Center for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA. rxol@cdc.gov
- Postexposure prophylaxis (PEP) after intravaginal exposure to human immunodeficiency virus (HIV) was investigated using the HIV type 2 (HIV-2)/pig-tailed macaque transmission model. PEP for 28 days with the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA;
- Cellular and species resistance to murine amphotropic, gibbon ape, and feline subgroup C leukemia viruses is strongly influenced by receptor expression levels and by receptor masking mechanisms.
- Unique Identifier : AIDSLINE GENBANK/AF239767
- Tailor CS; Nouri A; Kabat D; Department of Biochemistry and Molecular Biology, Oregon Health; Sciences University, Portland, Oregon 97201-3098, USA.; tailorc@ohsu.edu
- Chinese hamster ovary (CHO) cells are resistant to infections by gibbon ape leukemia virus (GALV) and amphotropic murine leukemia virus (A-MLV) unless they are pretreated with tunicamycin, an inhibitor of N-linked glycosylation. These viruses use the related sodium-phosphate symporters Pit1 and Pit2, respectively, as
- Postexposure prophylaxis for HIV after sexual assault [letter]
- JAMA. 2000 Sep 27;284(12):1516-8. Unique Identifier : AIDSLINE MED/20457276
- Myles JE; Hirozawa A; Katz MH; Kimmerling R; Bamberger JD
- [Adverse effects and infections caused by platelet concentrate]
- Rinsho Ketsueki. 2000 Jun;41(6):468-71. Unique Identifier : AIDSLINE MED/20376762
- Tadokoro K
- [Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T lymphocytes in EBV-related diseases]
- Rinsho Ketsueki. 2000 Jun;41(6):487-90. Unique Identifier : AIDSLINE MED/20376766
- Kuzushima K
- [Introduction to sterilization and disinfection of medical wastes contaminated with human virus]
- Rinsho Byori. 2000 May;Suppl 112:15-20. Unique Identifier : AIDSLINE MED/20358261
- Ichikawa S; Ohya H; Ito K; Kanagawa Prefectural College of Nursing and Medical Technology.
- In this paper, we describe sterilization and disinfection of medical wastes contaminated with blood borne-virus, such as Ebola virus, Marburg virus, Crimean-Congo hemorrhagic fever virus, Lassa virus, Hepatitis B virus and Human immunodeficiency virus.
- Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis.
- Kidney Int. 2000 Sep;58(3):1055-66. Unique Identifier : AIDSLINE MED/20429087
- Rosenkranz AR; Knight S; Sethi S; Alexander SI; Cotran RS; Mayadas TN; Department of Pathology, Brigham and Women's Hospital and Harvard; Medical School, Boston, Massachusetts, USA.
- BACKGROUND: Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis. METHODS: The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell re
- Glomerulosclerosis and viral gene expression in HIV-transgenic mice: role of nef.
- Kidney Int. 2000 Sep;58(3):1148-59. Unique Identifier : AIDSLINE MED/20429095
- Kajiyama W; Kopp JB; Marinos NJ; Klotman PE; Dickie P; Kidney Disease Section, Metabolic Diseases Branch, NIDDK, and; Imaging Facility, NIDR, NIH, Bethesda, Maryland, USA.
- BACKGROUND: Human immunodeficiency virus (HIV)-associated nephropathy is characterized by focal segmental glomerulosclerosis and microcystic tubular dilation. We have previously described a mouse transgenic for a Deltagag-pol HIV-1 genome, which develops glomerulosclerosis, cutaneous papillomas, and cataracts. METHODS
- Cohort study of the treatment of severe HIV-associated nephropathy with corticosteroids.
- Kidney Int. 2000 Sep;58(3):1253-60. Unique Identifier : AIDSLINE MED/20429105
- Eustace JA; Nuermberger E; Choi M; Scheel PJ Jr; Moore R; Briggs WA; Divisions of Nephrology and Infectious Disease, The Johns Hopkins; University Hospital, Baltimore, Maryland, USA.; jeustace@welch.jhu.edu
- BACKGROUND: Human immunodeficiency virus-associated nephropathy (HIVAN) results in rapidly progressive azotemia. The effectiveness and safety of corticosteroids in the treatment of HIVAN, however, remains controversial. METHODS: We conducted a retrospective cohort study of patients with biopsy-proven HIVAN and progres
- Magnetic resonance imaging detection of rat renal transplant rejection by monitoring macrophage infiltration.
- Kidney Int. 2000 Sep;58(3):1300-10. Unique Identifier : AIDSLINE MED/20429111
- Zhang Y; Dodd SJ; Hendrich KS; Williams M; Ho C; Pittsburgh NMR Center for Biomedical Research and Department of; Biological Sciences, Carnegie Mellon University, Pennsylvania,; USA.
- BACKGROUND: A rat renal transplantation model was studied by noninvasive magnetic resonance imaging (MRI) with an infusion of ultrasmall superparamagnetic iron oxide (USPIO) particles to test whether the accumulation of immune cells, such as macrophages, could be detected in vivo while the kidney transplant was being
- [Indirect cost assessment in health evaluation]
- Med Clin (Barc). 2000;114 Suppl 3:15-21. Unique Identifier : AIDSLINE MED/20450055
- Oliva Moreno J; Fundacion Gaspar Casal, Madrid. fgcasal@teleline.es
- Whether the indirect costs caused by a specific disease should be included in economic analysis of health issues is a continuous matter of study which is far from solved. Throughout the course of this paper, we will try to point out the reasons of recommending their inclusion in economic health analysis and the main t
- [Cost effectiveness analysis of highly active antiretroviral therapy in HIV asymptomatic patients]
- Med Clin (Barc). 2000;114 Suppl 3:62-7. Unique Identifier : AIDSLINE MED/20450062
- Pinto JL; Lopez Lavid C; Badia X; Coma A; Benavides A; Universitat Pompeu Fabra, Barcelona. jose.pinto@econ.upf.es
- BACKGROUND: Assessment of cost and effectiveness in highly active antiretroviral therapy (HAART) in HIV asymptomatic patients. PATIENTS AND METHODS: A cohort of several asymptomatic HIV-infected patients were observed under real practice and treated with two nucleosid analogues (AN) of which therapy was modified. A pr
- Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in Sao Paulo City, Brazil.
- Mem Inst Oswaldo Cruz. 2000 Sep-Oct;95(5):711-2. Unique Identifier : AIDSLINE MED/20453484
- Chieffi PP; Chiattone CS; Feltrim EN; Alves RC; Paschoalotti MA; Instituto de Medicina Tropical de Sao Paulo, Sao Paulo, SP,; 05403-000, Brasil. pchieffi@usp.br
- The frequency of coinfection with Strongyloides stercoralis and human T-cell leukemia/lymphoma virus type 1 (HTML-1) was determined in 91 blood donors examined at the blood bank of a large hospital in Sao Paulo city, Brazil . As control group 61 individuals, not infected by HTLV-1,
- Multiple isolates from aids patients: aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations.
- Mem Inst Oswaldo Cruz. 2000 Sep-Oct;95(5):729-32. Unique Identifier : AIDSLINE MED/20453488
- Saad MH; Telles MA; Porfirio F; Ferrazoli L; de Souza Fonseca L; Johnson W Jr; Riley LW; Laboratorio de Hanseniase, Departamento de Medicina Tropical,; Instituto Oswaldo Cruz, Rio de Janeiro, RJ, 21045-900, Brasil.; saad@ioc.fiocruz.br
- Twenty-one Mycobacterium avium multisolates, from ten human immunodeficiency virus-infected patients, were typed by restriction fragment length polymorphism using as marker the IS1245 and characterized by minimum inhibitory concentration for nine different antibiotics. Two out of four patients harboring multisolates w
- Visceral leishmaniosis caused by Leishmania (L.) mexicana in a Mexican patient with human immunodeficiency virus infection.
- Mem Inst Oswaldo Cruz. 2000 Sep-Oct;95(5):733-7. Unique Identifier : AIDSLINE MED/20453489
- Ramos-Santos C; Hernandez-Montes O; Sanchez-Tejeda G; Monroy-Ostria A; Clinica 25, Instituto Mexicano del Seguro Social, Mexico City,; Mexico.
- A 36 year old male was admitted in December 1997 to hospital with afternoon fever, malaise and hepatosplenomegaly. He also had a dry cough, dyspnoea and anaemia. Pneumonia caused by Pneumocystis carinii and human immunodeficiency virus (HIV) infection were documented. The HIV infection was confirmed in 1997 with 290,0
- Changes in calciotropic hormones and biochemical markers of bone metabolism in patients with human immunodeficiency virus infection.
- Metabolism. 2000 Sep;49(9):1134-9. Unique Identifier : AIDSLINE MED/20469108
- Teichmann J; Stephan E; Discher T; Lange U; Federlin K; Stracke H; Friese G; Lohmeyer J; Bretzel RG; Medizinische Klinik III und Poliklinik,; Justus-Liebig-Universitat Giessen, Germany.
- Data on the bone metabolism of human immunodeficiency virus (HIV)-infected patients are still extremely rare. To investigate the influence of HIV infection on the calciotropic hormones and markers of bone metabolism, we therefore performed a cross-sectional study on 100 patients (65 males and 35 females) with proven H
- Lamivudine in the treatment of acute hepatitis B [letter]
- N Engl J Med. 2000 Oct 12;343(15):1123-4. Unique Identifier : AIDSLINE MED/20464365
- Reshef R; Sbeit W; Tur-Kaspa R
- Self-esteem and optimism in men and women infected with HIV.
- Nurs Res. 2000 Sep-Oct;49(5):262-71. Unique Identifier : AIDSLINE MED/20462645
- Anderson EH; University of Connecticut School of Nursing, Storrs 06269-2026,; USA. eanderso@uconnvm.uconn.edu
- BACKGROUND: Self-esteem and optimism have been associated with appraisal and outcomes in a variety of situations. The degree to which the contribution of self-esteem and optimism to outcomes over time is accounted for by the differences in threat (primary) or resource (secondary) appraisal has not been established in
- High prevalence of iliofemoral venous thrombosis with severe groin infection among injecting drug users in North East Scotland: successful use of low molecular weight heparin with antibiotics.
- Postgrad Med J. 2000 Sep;76(899):561-5. Unique Identifier : AIDSLINE MED/20420267
- Mackenzie AR; Laing RB; Douglas JG; Greaves M; Smith CC; Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland.; a.r.mackenzie@arh.grampian.scot.nhs.uk
- Injecting drug use, mainly of heroin, currently represents a major public health issue in the North East of Scotland. The recent tendency of the committed injecting drug user to inject into the groin has created novel problems for the Infection Unit.Data are presented on 20 consecutive patients admitted between 1994 a
- A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago.
- Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10532-7. Unique Identifier : AIDSLINE GENBANK/AF279595
- Cleghorn FR; Jack N; Carr JK; Edwards J; Mahabir B; Sill A; McDanal CB; Connolly SM; Goodman D; Bennetts RQ; O'Brien TR; Weinhold KJ; Bartholomew C; Blattner WA; Greenberg ML; Institute of Human Virology, University of Maryland, Baltimore,; MD 21201, USA.
- HIV-1 transmission worldwide is predominantly associated with heterosexual activity, and non-clade B viruses account for the most spread. The HIV-1 epidemic in Trinidad /
- Cardiomyopathy in AIDS: a pathophysiological perspective.
- Prog Cardiovasc Dis. 2000 Sep-Oct;43(2):151-70. Unique Identifier : AIDSLINE MED/20466259
- Lewis W; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322, USA. wlewis@emory.edu
- This report addresses issues of pathogenesis, pathophysiology, and epidemiology of an increasingly prevalent cardiomyopathy in acquired immunodeficiency syndrome (AIDS). As patient survival increases with more effective antiretroviral therapy, cardiomyopathy in AIDS will become more apparent. The interactions of cellu
- [Progressive multifocal leukoencephalopathy an chronic lymphocytic leukemia]
- Rev Med Interne. 2000 Aug;21(8):698-700. Unique Identifier : AIDSLINE MED/20444639
- Attout H; Rahmeh F; Lehuede G; Girardel M; Ziegler F; Service de neurologie, centre hospitalier, Belfort, France.
- INTRODUCTION: Progressive multifocal leukoencephalopathy is a demyelinating disease resulting from an opportunistic infection of the central nervous system by JC papovavirus. It mostly occurs in patients with an underlying immunosuppressive disorder. In the era of acquired immunodeficiency syndrome it is observed with
- [Increased activity of metalloproteinases and their inhibitors in cerebrospinal fluid of patients with tropical spastic paraparesis]
- Rev Med Chil. 2000 Jun;128(6):585-92. Unique Identifier : AIDSLINE MED/20470056
- Valenzuela MA; Collados L; Kettlun AM; Gonzalez F; Cartier L; Departamento de Bioquimica y Biologia Molecular, Facultad de; Ciencias Quimicas y Farmaceuticas, Universidad de Chile.
- BACKGROUND: Proteolytic modifications of neuronal surfaces and the surrounding extracellular matrix are very important in neuronal development and regeneration. Increased activity of matrix metalloproteinases (MMPs) and their tissue inhibitors, due to secretion by macrophages and lymphocytes, occur in inflammatory pro
- Molecular analysis of human immunoglobulin heavy chain variable region associated determinants recognized by anti-VH3 antibodies 7B4, B6 and D12.
- Unique Identifier : AIDSLINE MED/20467769
- Suleyman S; Thompson KM; Mageed RA; Natvig JB
- 7B4, B6 and D12 are murine monoclonal antibodies (MoAb) that bind to some human immunoglobulin heavy chain products of the closely related V3-30, V3-30.3 and V3-33 genes from the VH3 family. B6 and D12 have additional reactivities with some immunoglobulins (Ig) encoded by the V3-11 and V3-7 genes; D12 also reacts with
- Down-regulation of interleukin-12, interleukin-12R expression/activity mediates the switch from Th1 to Th2 granuloma response during murine Schistosomiasis mansoni.
- Scand J Immunol. 2000 Oct;52(4):385-92. Unique Identifier : AIDSLINE MED/20467775
- Todt JC; Whitfield JR; Ivard SR; Boros DL; Department of Immunology and Microbiology, Wayne State,; University School of Medicine, Detroit, MI 48201, USA.
- In murine schistosomiasis mansoni the worm egg-induced granulomatous inflammation is bi-phasic: an initial Th1 type is subsequently switched to a Th2 type response. Analysis of the cellular, molecular base of the Th1-associated response (5-6 weeks post infection) revealed mRNA messages for interleukin (IL)-12 p40, IL-
- Family secrets: disclosure of HIV status among gay men with HIV/AIDS to the family of origin.
- Soc Work Health Care. 2000;30(3):1-17. Unique Identifier : AIDSLINE MED/20336352
- Kadushin G; University of Wisconsin-Milwaukee, School of Social Welfare,; 53201, USA. kadushin@csd.uwm.edu
- A mail survey obtained a sample of 117 gay men with HIV/AIDS to examine levels of disclosure of HIV status to the family of origin and the association between disclosure and levels of support and barriers to support from the family. Among men with HIV there was a significant difference in knowledge of HIV status betwe
- AIDS: the development of a gender appropriate research intervention.
- Soc Work Health Care. 2000;30(3):19-37. Unique Identifier : AIDSLINE MED/20336353
- Goicoechea-Balbona A; Barnaby C; Ellis I; Foxworth V; Morgan State University, School of Education and Urban Studies,; Department of Social Work, Baltimore, MD 21251, USA.
- This study is part of an AIDS research-service project, implemented by a faculty member and graduate students from the University of Maryland, School of Social Work. It focuses on the last of the completed studies between 1993 and 1998. To access women-centered health care services in Washington, D.C., a four member t
- Transfusion-transmitted infectious diseases in Argentina, 1995 through 1997.
- Transfusion. 2000 Sep;40(9):1048-53. Unique Identifier : AIDSLINE MED/20446277
- Schmunis GA; Zicker F; Segura EL; del Pozo AE; Pan American Health Organization, Regional Office of the World; Health Organization for the Americas, Washington, DC, USA.; schmunig@paho.org
- BACKGROUND: Assessment of the safety of the blood supply, the quality of screening procedures, and the risk of transfusion transmission of infectious diseases in any country can be estimated by reviewing the records of blood donations and screening procedures and the prevalence of serologic markers of infectious disea
- The cost-effectiveness of postoperative recovery of RBCs in preventing transfusion-associated virus transmission after joint arthroplasty.
- Transfusion. 2000 Sep;40(9):1063-6. Unique Identifier : AIDSLINE MED/20446280
- Jackson BR; Umlas J; AuBuchon JP; Department of Pathology, Dartmouth-Hitchcock Medical Center,; Lebanon, New Hampshire 03756, USA.
- BACKGROUND: The return of joint drainage after hip and knee arthroplasty is a widely used but expensive blood-conservation technique. STUDY DESIGN AND METHODS: A Markov decision analysis model was used to evaluate the cost-effectiveness of postoperative RBC recovery in preventing viral complications of allogeneic tran
- Elimination of both cell-free and cell-associated HIV infectivity in plasma by a filtration/methylene blue photoinactivation system.
- Transfusion. 2000 Sep;40(9):1081-7. Unique Identifier : AIDSLINE MED/20446284
- Abe H; Yamada-Ohnishi Y; Hirayama J; Owada T; Ikeda H; Ikebuchi K; Hokkaido Red Cross Blood Center, Sapporo, Japan.; abeh@hokkaido.bc.jrc.or.jp
- BACKGROUND: Methylene blue phototreatment effectively inactivates cell-free viruses in plasma while maintaining coagulation activities. However, this treatment is considered to be less effective for cell-associated virus inactivation. This report describes a new virus elimination system designed to eliminate cell-asso
- Despite high levels of lymphocyte homing receptor alpha4beta7 integrin after small bowel allotransplantation, it is not critical for rejection.
- Transplant Proc. 2000 Sep;32(6):1267-8. Unique Identifier : AIDSLINE MED/20453627
- Kellersmann R; Zhong R; Grant D; Garcia B; Blomer A; Liu W; Wagner N; Muller W; Jevnikar A; Thiede A; Lazarovits A; University of West Ontario and the J.P. Robarts Research; Institute, London, Ontario, Canada.
- Intragraft expression of p38 in rat small bowel transplantation.
- Transplant Proc. 2000 Sep;32(6):1281-2. Unique Identifier : AIDSLINE MED/20453634
- Tatekawa Y; Kanehiro H; Kanokogi H; Nakajima Y; Ko S; Hisanaga M; Aomatsu Y; Nagao M; Kobayashi T; Urizono Y; Shibaji T; Kanemura T; Yamada T; Ogawa S; Nakano H; The First Department of Surgery, Nara Medical University, Nara,; Japan.
- IL-2 promotes the subset restoration of intraepithelial lymphocytes after ischemia/reperfusion injury.
- Transplant Proc. 2000 Sep;32(6):1305-6. Unique Identifier : AIDSLINE MED/20453645
- Nussler NC; O'Brien J; Stange B; Platz KP; Neuhaus P; Muller AR; Department of Surgery, Charite Campus Virchow-Klinikum, Humboldt; University Berlin, Berlin, Germany.
- Treatment of chronic hepatitis B with lamivudine in renal allograft recipients.
- Transplant Proc. 2000 Sep;32(6):1369-70. Unique Identifier : AIDSLINE MED/20453668
- Lewandowska D; Durlik M; Kukula K; Cieciura T; Ciecierski R; Walewska-Zielecka B; Szmidt J; Rowinski W; Lao M; Transplantation Institute, Medical University of Warsaw, Warsaw,; Poland.
- Effects of the depletion of CD8(+) T cells and monocytes on the proliferative responses of peripheral blood leucocytes from Trypanosoma evansi-infected sheep.
- Vet Parasitol. 2000 Sep 10;92(1):25-35. Unique Identifier : AIDSLINE MED/20396561
- Onah DN; Hopkins J; Luckins AG; Centre for Tropical Veterinary Medicine, University of Edinburgh,; Scotland, Edinburgh, UK. denis@fc.miyazaki-med.ac.jp
- Sheep peripheral blood mononuclear cells and those depleted of CD8(+) T cells and/or monocytes were stimulated with polyclonal mitogens and specific antigens, and analysed by means of cell proliferation assay procedure to examine whether these cell populations are involved in Trypanosoma evansi-induced immunosuppressi
- [PCR diagnosis of sequences of a novel human herpes virus type 8 in patients with Kaposi sarcoma in Russia]
- Vopr Virusol. 2000 Jul-Aug;45(4):13-7. Unique Identifier : AIDSLINE MED/20426635
- Galetskii SA; Kadyrova EL; Kozyrev IuL; Molochkov AV; Seniuta NB; Shakhgil'dian VI; Kravchenko AV; Budoragin ES; Chistiakova IA; Lezvinskaia EM; Kazantseva IA; Samsonov VA; Molochkov VA; Gurtsevich VE
- Associations of a new human herpesvirus type 8 (HHV-8) with different forms of Kaposi s sarcoma (KS) in Russia have been studied. Search for this virus genetic information has been carried out in biopsy specimens of benign and malignant tumors other than KS, and probable sites of H
- [Epidemiological and genetical characteristics of first forty cases of HIV infection in Perm region]
- Vopr Virusol. 2000 Jul-Aug;45(4):18-21. Unique Identifier : AIDSLINE MED/20426636
- Bobkov AF; Zverev SIa; Bobkova MR; Ostashova VL; Krasnikova LA; Zubrikov VV; Zhalnin BB; Kazennova EV; Khanina TA; Kostina LE; Krendel' BIu; Ivanova ES; Iurganova GA; Luzin PM; Pokrovskii VV
- The paper sums up molecular epidemiological data on all variants of human immunodeficiency virus type 1 (HIV-1) isolated in the Perm region in August 1988-March 1998. A total of 24 foci (40 cases) of HIV infection were detected; 20 of these were imported from other regions (Russian Federation,
- Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine.
- Vaccine. 2000 Aug 15;19(1):95-102. Unique Identifier : AIDSLINE MED/20385110
- Billaut-Mulot O; Idziorek T; Ban E; Kremer L; Dupre L; Loyens M; Riveau G; Locht C; Capron A; Bahr GM; Unite Inserm 167, Pasteur de Lille, Lille, France.
- Many different HIV-1 vaccine strategies have been developed, but as yet none has been completely successful. Promising results from combined DNA prime/protein boost vaccines have been reported. Specific immune responses generated by DNA vaccines can be modulated by the co-delivery of genes coding for cytokines. In thi
- CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi.
- Vaccine. 2000 Sep 15;19(2-3):234-42. Unique Identifier : AIDSLINE MED/20389724
- Corral RS; Petray PB; Laboratorio de Virologia, Hospital de Ninos Ricardo Gutierrez,; Gallo 1330, 1425, Buenos Aires, Argentina. ppetray@conicet.gov.ar
- Th1-type immune response plays a critical role in resistance to Trypanosoma cruzi infection. We asked whether a synthetic oligodeoxynucleotide that contains immunostimulatory CpG motifs (CpG ODN), known to promote a Th1 response, could act as an adjuvant in immunization with parasite antigens. Mice immunized with a wh
- Cell-mediated immunity to low doses of SIVsm in cynomolgus macaques did not confer protection against mucosal rechallenge.
- Vaccine. 2000 Sep 15;19(2-3):298-307. Unique Identifier : AIDSLINE MED/20389731
- Makitalo B; Bottiger1 P; Biberfeld G; Thorstensson R; Swedish Institute for Infectious Disease Control and Microbiology; Tumour Biology Center, Karolinska Institute, SE-171 82, Solna,; Sweden. barbro.makitalo@smi.ki.se
- Simian immunodeficiency virus (SIV) infection of macaques is a useful model for studies of the roles of different immune responses against viruses that cause (AIDS). In this study, six cynomolgus macaques were inoculated intrarectally with subinfectious or infectious doses of SIVsm to assess the SIV specific immunity,
- Recombinant modified vaccinia virus Ankara efficiently restimulates human cytotoxic T lymphocytes in vitro.
- Unique Identifier : AIDSLINE MED/20389734
- Dorrell L; O'Callaghan CA; Britton W; Hambleton S; McMichael A; Smith GL; Rowland-Jones S; Blanchard TJ
- The immunogenicity of recombinant modified vaccinia Ankara, a highly attenuated vaccinia virus, expressing influenza nucleoprotein (MVA-NP) and HIV-1 gag (MVA-gag) was investigated. Restimulation of peripheral blood lymphocytes of healthy subjects with MVA-NP led to expansion of CTL with specificity for known NP epito
- An immunological profile of Balb/c mice protected from airborne challenge following vaccination with a live attenuated Venezuelan equine encephalitis virus vaccine.
- Vaccine. 2000 Sep 15;19(2-3):337-47. Unique Identifier : AIDSLINE MED/20389735
- Bennett AM; Elvin SJ; Wright AJ; Jones SM; Phillpotts RJ; Defence Evaluation and Research Agency, CBD n Down, Salisbury SP4; 0JQ, Porto, UK.
- The live attenuated vaccine strain of Venezuelan equine encephalitis virus (VEEV), TC-83, protects mice against challenge (subcutaneous and aerosol) with virulent VEEV but is not suitable for widescale human use. Elucidation of the immune response profile of protected mice should assist in the development of an improv
- Herpes simplex virus esophagitis in the immunocompetent host: an overview.
- Am J Gastroenterol. 2000 Sep;95(9):2171-6. Unique Identifier : AIDSLINE MED/20460279
- Ramanathan J; Rammouni M; Baran J Jr; Khatib R; Department of Medicine, St. John Hospital and Medical Center,; Detroit, Michigan 48236, USA.
- OBJECTIVE: The aim of this study was to delineate the characteristics of herpes simplex virus esophagitis (HSVE) in the immunocompetent host. METHODS: The study entailed a case report and a review of relevant literature through a MEDLINE search back to 1966. All cases with documented HSVE in patients without immunosup
- Microsporidial AIDS cholangiopathy due to Encephalitozoon intestinalis: case report and review.
- Unique Identifier : AIDSLINE MED/20460310
- Sheikh RA; Prindiville TP; Yenamandra S; Munn RJ; Ruebner BH; Department of Internal Medicine, University of California Davis,
- Microsporidia are increasingly recognized as opportunistic infections in immunodeficient patients, predominantly patients with AIDS. The two microsporidia most commonly associated with disease in AIDS patients are Enterocytozoon bieneusi and Encephalitozoon intestinalis (previously known as Septata intestinalis). The
- Absence of maternal-fetal transmission of human immunodeficiency virus type 1 to second-trimester fetuses.
- Am J Obstet Gynecol. 2000 Sep;183(3):638-42. Unique Identifier : AIDSLINE MED/20448679
- Pascual A; Bruna I; Cerrolaza J; Moreno P; Ramos JT; Noriega AR; Delgado R; Department of Gynecology and Obstetrics, Hospital de Mostoles,; Madrid, Spain.
- OBJECTIVE: The aim of this study was to evaluate the contribution of in utero infection to the vertical transmission of human immunodeficiency virus type 1 during the second trimester. STUDY DESIGN: We examined fetal tissues from 21 second-trimester prostaglandin-induced abortions among human immunodeficiency virus ty
- [Drug-induced oral ulcerations]
- Ann Med Interne (Paris). 2000 Jun;151(4):248-54. Unique Identifier : AIDSLINE MED/20382585
- Madinier I; Berry N; Chichmanian RM; UFR d'Odontologie, Universite de Nice-Sophia Antipolis, 24,; avenue des Diables-Bleus, 06357 Nice Cedex 4.
- Different side effects of drugs have been described in the oral cavity, including oral ulcerations. Direct contact between drugs and oral mucosa may induce chemical burn or local hypersensitivity. Less frequently, these drug-induced oral ulcerations are part of a complex reaction with cutaneous or systemic manifestati
- [Current situation of nucleoside reverse transcriptase inhibitors]
- Ann Med Interne (Paris). 2000 Jun;151(4):255-9. Unique Identifier : AIDSLINE MED/20382586
- Ngo Van P; Laboratoire ABBOTT, 12, rue de la Couture, SILIC 233, 94528; Rungis Cedex.
- Nucleosidic reverse transcriptase inhibitors were the first class of drugs to be used for the treatment of HIV disease. Recent data on the complex pathways allowing the virus to adapt to the drugs will lead to better management of the phenomena. Similarly, better understanding of the mechanism of their toxicity will a
- [Non-nucleoside reverse transcriptase inhibitors]
- Ann Med Interne (Paris). 2000 Jun;151(4):260-7. Unique Identifier : AIDSLINE MED/20382587
- Joly V; Yeni P; Service de Medecine Interne, Hopital Bichat, 75877 Paris Cedex; 18.
- The non-nucleoside reverse transcriptase inhibitors (NNRTIs) directly inhibit the HIV-1 reverse transcriptase (RT) by binding in a reversible and non-competitive manner to the enzyme. The currently available NNRTIs are nevirapine ,
- [HIV protease inhibitors]
- Ann Med Interne (Paris). 2000 Jun;151(4):268-77. Unique Identifier : AIDSLINE MED/20382588
- Silbermann B; Yousry C; Salmon-Ceron D; Service de Medecine Interne 2, Hopital Cochin, 27, rue du; Faubourg-Saint-Jacques, 75014 Paris.
- [Metabolic complications associated with use of protease inhibitors]
- Ann Med Interne (Paris). 2000 Jun;151(4):278-82. Unique Identifier : AIDSLINE MED/20382589
- Mosnier-Pudar H; Service des Maladies Endocrines et Metaboliques, Hopital; Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris.
- The potency of highly active antiretroviral therapy, including protease inhibitors have led to declining morbidity and mortality in patients with HIV infection. However the use of protease inhibitors is associated with onset of morphologic and metabolic disorders. A
- [Anti-HIV chemoprophylaxis for blood-exposure accidents]
- Ann Med Interne (Paris). 2000 Jun;151(4):283-90. Unique Identifier : AIDSLINE MED/20382590
- Bouvet E; Casalino E; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Cl. -Bernard, 46, rue Henri-Huchard, 75877 Paris Cedex 18.
- Chemoprophylaxis against HIV after accidental blood exposures represents a new indication for antiretroviral drugs. Efficacy has been suggested by the results of a case-control study in health care workers and the reduction of mother to infant transmission of HIV with zidovudine. The post-exposure treatment should be
- [The value of plasma antiretroviral drug monitoring in the management of HIV infected patients]
- Ann Med Interne (Paris). 2000 Jun;151(4):291-6. Unique Identifier : AIDSLINE MED/20382591
- Treluyer JM; Service de Pharmacologie Clinique, Hopital; Saint-Vincent-de-Paul, 82, avenue Denfert-Rochereau, 75674 Paris; Cedex 14.
- Antiretroviral drugs exhibit significant between-patient pharmacokinetic variability. Over the past years, data have emerged demonstrating a link between antiretroviral drug concentrations and efficacy or side-effects. As a result, the issue of therapeutic drug monitoring for these compounds are arisen; many published
- [Adherence to antiretroviral treatments with a protease inhibitor in HIV-infected patients]
- Ann Med Interne (Paris). 2000 Jun;151(4):297-302. Unique Identifier : AIDSLINE MED/20382592
- Salmon-Ceron D; Deleuze J; Coste J; Guerin C; Ginsburg C; Blanche P; Finkielsztejn L; Pecqueux L; Chaput S; Gorin I; Sicard D; Service de Medecine Interne, Hopital Cochin, Paris.; dominique.salmon@cch.ap-hop-paris.fr
- OBJECTIVE: Long-term therapeutic success of powerful antiretroviral treatments dependent on patient adherence. This study was conducted to assess the difficulties HIV-infected patients with advanced-stage disease encounter in adhering to antiretroviral treatments with a protease inhibitor. PATIENTS AND METHODS: A pros
- Clinical course of patients with major histocompatibility complex class II deficiency.
- Arch Dis Child. 2000 Oct;83(4):356-9. Unique Identifier : AIDSLINE MED/20455310
- Saleem MA; Arkwright PD; Davies EG; Cant AJ; Veys PA; The Hospital for Sick Children, Great Ormond St, London, WC1N; 3JH, UK.
- The clinical course of 10 children who have been diagnosed with major histocompatibility complex (MHC) class II deficiency (bare lymphocyte syndrome) in the UK over the past eight years is described. They have had a generally poor prognosis, with only two of the 10 still alive despite eight attempts at bone marrow tra
- Delayed medical care after diagnosis in a US national probability sample of persons infected with human immunodeficiency virus.
- Arch Intern Med. 2000 Sep 25;160(17):2614-22. Unique Identifier : AIDSLINE MED/20455321
- Turner BJ; Cunningham WE; Duan N; Andersen RM; Shapiro MF; Bozzette SA; Nakazono T; Morton S; Crystal S; St Clair P; Stein M; Zierler S; University of Pennsylvania, General Internal Medicine, 1119; Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021.; bturner@mail.med.upenn.edu
- OBJECTIVE: To identify health care and patient factors associated with delayed initial medical care for human immunodeficiency virus (HIV) infection. DESIGN: Survey of a national probability sample of persons with HIV in care. SETTING: Medical practices in the contiguous United States .
- Evaluation of effectiveness of the 23-valent pneumococcal capsular polysaccharide vaccine for HIV-infected patients.
- Arch Intern Med. 2000 Sep 25;160(17):2633-8. Unique Identifier : AIDSLINE MED/20455323
- Breiman RF; Keller DW; Phelan MA; Sniadack DH; Stephens DS; Rimland D; Farley MM; Schuchat A; Reingold AL; Centers for Disease Control and Prevention, 1600 Clifton Rd, MS; C-12, Atlanta, GA 30333, USA. rfb2@cdc.gov
- BACKGROUND: We conducted a retrospective case-control study to evaluate effectiveness of pneumococcal vaccine against invasive disease among adults with human immunodeficiency virus (HIV) infection in San Francisco, Calif, and Atlanta, Ga. METHODS: Case patients were 18- to 55-year-old subjects with HIV infection who
- [Importance of blood tests for the diagnosis of drug allergies]
- Allerg Immunol (Paris). 2000 Jun;32(6):226-30. Unique Identifier : AIDSLINE MED/20426530
- Veniere A; Brousse R; Menelet I; Ait-Tamar H; Sainte-Laudy J; Sonneville A; CHU, Tours.
- This work is devoted to the study of 22 dossiers of persons who have presented with clinical signs following taking a drug. The study was confined to patients in whom the symptoms had as origin a hypersensitivity (true or non-specific by histamine release). This study has allowed analysis of the value of several serol
- Quantitative detection of RT activity by PERT assay: feasibility and limits to a standardized screening assay for human vaccines.
- Biologicals. 2000 Jun;28(2):67-80. Unique Identifier : AIDSLINE MED/20340123
- Andre M; Morgeaux S; Fuchs F; Agence Francaise de Securite Sanitaire des Produits de Sante,; Direction des Laboratoires et des Controles, Unite de Controle; des Medicaments Immunologiques, Lyon, France.
- The detection of adventitious retroviruses has always been critical for assessing the safety concerns associated with viral vaccines. Assays for the enzymatic activity of reverse transcriptase (RT) are used as general methods for the detection of both known and unknown retroviruses. Several studies using newly-develop
- Evaluation and validation of virus removal by ultrafiltration during the production of diaspirin crosslinked haemoglobin (DCLHb).
- Biologicals. 2000 Jun;28(2):81-94. Unique Identifier : AIDSLINE MED/20340124
- Azari M; Boose JA; Burhop KE; Camacho T; Catarello J; Darling A; Ebeling AA; Estep TN; Pearson L; Guzder S; Herren J; Ogle K; Paine J; Rohn K; Sarajari R; Sun CS; Zhang L; Hemoglobin Therapeutics Program, Baxter Healthcare Corporation,; Round Lake, IL 60073-9799, USA.
- Virus retention during ultrafiltration through A/G Technology filter cartridges was investigated to characterize the removal process and validate the degree of virus titre reduction during the filtration of red blood cell haemolysates performed as part of the production of diaspirin crosslinked haemoglobin (DCLHb). Wh
- Inactivation and clearance of viruses during the manufacture of high purity factor IX.
- Biologicals. 2000 Sep;28(3):129-36. Unique Identifier : AIDSLINE MED/20422371
- Johnston A; Macgregor A; Borovec S; Hattarki M; Stuckly K; Anderson D; Goss NH; Oates A; Uren E; Research & Development, CSL Limited, Bioplasma Division, 189-209; Camp Road, Broadmeadows, Victoria, 3047, Australia.; anna_johnston@csl.com.au
- Haemophilia is a bleeding disorder characterised by a deficiency in Factor IX. Replacement therapy in the form of a Factor IX concentrate is a widely accepted practice. In this paper we describe a double virus inactivated chromatographic process for producing a high purity Factor IX product, MonoFIX((R))-VF. The proce
- Nurse practitioner, nurse midwife and physician assistant attitudes and care practices related to persons with HIV/AIDS.
- J Am Acad Nurse Pract. 2000 Feb;12(2):35-41. Unique Identifier : AIDSLINE MED/20487925
- Martin JE; Bedimo AL; Department of Preventive Medicine, Louisiana State University; Medical Center, New Orleans 70118, USA. jmarti@lsumc.edu
- Although multiple studies of nurses attitudes toward people living with HIV/AIDS (PLWAs) can be found in the literature, little is known about the attitudes, beliefs and practices of nurse practitioners (NPs), certified nurse midwives (CNMs), and physician assistants (PAs). A survey including a 21-item AIDS Attitude
- High-dose percutaneous ethanol injection therapy of liver tumors. Patient acceptance and complications.
- Acta Radiol. 2000 Sep;41(5):458-63. Unique Identifier : AIDSLINE MED/20468981
- Elgindy N; Lindholm H; Gunven P; Department of Diagnostic Radiology, Karolinska Hospital,; Stockholm, Sweden.
- PURPOSE: To study the safety of high-dose ethanol injections in liver tumors and their acceptability as out-patient procedures under local anesthesia. MATERIAL AND METHODS: Twenty-nine patients received 20-95 ml of 95% ethanol by 62 percutaneous injections under local anesthesia. Pain was assessed by a visual analogue
- Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease.
- Br J Clin Pharmacol. 2000 Aug;50(2):108-15. Unique Identifier : AIDSLINE MED/20389268
- Khaliq Y; Gallicano K; Seguin I; Fyke K; Carignan G; Bulman D; Badley A; Cameron DW; Clinical Investigation Unit, Ottawa Hospital Research Institute,; Ontario, Canada.
- AIMS: To evaluate the single-dose and multiple-dose pharmacokinetics of nelfinavir and its active M8 metabolite in eight HIV-seropositive patients with liver disease, and to examine the relationship between CYP2C19 activity (genotype and plasma M8/nelfinavir metabolic ratio) and the severity of liver disease in these
- Re: 'Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir' [comment]
- Unique Identifier : AIDSLINE MED/20389265 P
- Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir [see comments]
- Br J Clin Pharmacol. 2000 Aug;50(2):99-107. Unique Identifier : AIDSLINE MED/20389267
- Muirhead GJ; Wulff MB; Fielding A; Kleinermans D; Buss N; Early Clinical Research Group, Pfizer Central Research, Sandwich,; Kent, UK. Gary_Muirhead@sandwich.pfizer.com
- AIMS: To investigate the effect of the antiretroviral protease inhibitors saquinavir (soft gelatin capsule) and ritonavir on the pharmacokinetic properties and tolerability of sildenafil and to investigate the effect of sildenafil on the steady-state pharmacokinetic
- [Cytomegalovirus retinitis and optic neuropathy in a case of an infectious HIV syndrome]
- Oftalmologia. 1999;49(4):78-81. Unique Identifier : AIDSLINE MED/20475494
- Munteanu G; Munteanu M; Clinica de Oftalmologie, Timisoara.
- It is presented a case report of HIV syndrome complicated with cytomegalovirus retinitis and anterior ischemic optic neuropathy. It is reported a 36-years-old with type-B hemophilia and HIV-positive since few years. Despite treatment not recovered of ocular findings is obtained. So
- Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells.
- Biochemistry. 2000 Sep 19;39(37):11194-204. Unique Identifier : AIDSLINE MED/20442071
- Zhu X; Borchers C; Bienstock RJ; Tomer KB; Laboratory of Structural Biology and Scientific Computing; Laboratory, National Institute of Environmental Health Sciences,; National Institutes of Health, P.O. Box 12233, Research Triangle; Park, North Carolina 27709, USA.
- An analytical approach is reported for the characterization of the specific glycans found on highly glycosylated proteins based on a combination of specific proteolysis and deglycosylation combined with two different mass spectrometric approaches, matrix-assisted laser desorption/ionization mass spectrometry, and nano
- Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.
- Biochemistry. 2000 Sep 19;39(37):11205-15. Unique Identifier : AIDSLINE MED/20442072
- Mu L; Sarafianos SG; Nicklaus MC; Russ P; Siddiqui MA; Ford H Jr; Mitsuya H; Le R; Kodama E; Meier C; Knispel T; Anderson L; Barchi JJ Jr; Marquez VE; Laboratory of Medicinal Chemistry, Division of Basic Sciences,; and Experimental Retrovirology Section, Medicine Branch, Division; of Clinical Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.
- Molecular dynamics simulations of a ternary complex of HIV-1 reverse transcriptase (RT), double-stranded DNA, and bound dideoxynucleoside-5 -triphosphate (RT-DNA-ddNTP), utilizing the ddNTPs ddATP, betaFddATP, and alphaFddATP, explain the experimentally observed order of potency of these 5 -triphosphates as inhibitors
- Estimation of completeness of AIDS case reporting in Massachusetts.
- Epidemiology. 2000 Mar;11(2):209-13. Unique Identifier : AIDSLINE MED/20471629
- Jara MM; Gallagher KM; Schieman S; AIDS Surveillance Program, Massachusetts Department of Public; Health, Boston 02130, USA.
- One of the most important aspects of any surveillance system is degree of completeness. We conducted a multiple source capture-recapture study using the 1994 Massachusetts Uniform Hospital Discharge Data Set (UHDDS) and Medicaid claims data to evaluate the completeness of the state s AIDS registry. We used encrypted s
- 8-Difluoromethoxy-4-quinolone derivatives as anti-feline immunodeficiency virus (FIV) agents: important structural features for inhibitory activity of FIV replication.
- J Vet Med Sci. 2000 May;62(5):499-504. Unique Identifier : AIDSLINE MED/20309238
- Kashiwase H; Katsube T; Kimura T; Nishigaki T; Yamashita M; Biological Research Laboratories, Sankyo Co., Ltd. Hiromachi,; Tokyo ,Japan.
- The inhibitory activities of various 8-difluoromethoxy-4-quinolone derivatives against feline immunodeficiency virus (FIV) replication in the chronically infected cell line P-CrFK were investigated. Certain derivatives were found to inhibit FIV production from P-CrFK cells in a dose-dependent manner without exhibiting
- Influenza and its vaccination in HIV1-AIDS patients [editorial]
- Biomed Pharmacother. 2000 May;54(4):175-7. Unique Identifier : AIDSLINE MED/20329116
- Mathe G
- Influenza vaccination of HIV1-seropositive subjects generally protects against specific flu, especially if the patients have not reached a too-advanced stage. Influenza vaccination, as spontaneous influenza, can increase viral load or induce a rebound at a PCR-imperceptible phase of HIV1. Recombinant canarypox vectors
- Current status and future issues in the treatment of HIV-1 infection.
- Int J Hematol. 2000 Jul;72(1):20-7. Unique Identifier : AIDSLINE MED/20433582
- Matsushita S; Department of Clinical Retrovirology and Infectious Diseases,; Kumamoto University, Japan.
- Over the past 5 years, advances in human immunodeficiency virus type 1 (HIV-1) clinical research and data on the effectiveness of potent combination therapy have substantially influenced the overall perspective of the long-term management of HIV-1 disease. It is now ge
- Real-time polymerase chain reaction for quantification of HTLV-1 proviral load: application for analyzing aberrant integration of the proviral DNA in adult T-cell leukemia.
- Int J Hematol. 2000 Jul;72(1):79-84. Unique Identifier : AIDSLINE MED/20433592
- Kamihira S; Dateki N; Sugahara K; Yamada Y; Tomonaga M; Maeda T; Tahara M; Department of Laboratory Medicine, Nagasaki University School of; Medicine, Japan. kamihira@net.nagasaki-u.ac.jp
- We describe the establishment of a real-time polymerase chain reaction (PCR) assay for the quantitative estimation of human T-cell leukemia virus type 1 (HTLV-1) proviral load using a LightCycler Technology (Roche Diagnostics, Mannheim, Germany ) instrument. Proviral DNA level repr
- Multiple nonfunctional alleles of CCR5 are frequent in various human populations.
- Blood. 2000 Sep 1;96(5):1638-45. Unique Identifier : AIDSLINE MED/20417735
- Blanpain C; Lee B; Tackoen M; Puffer B; Boom A; Libert F; Sharron M; Wittamer V; Vassart G; Doms RW; Parmentier M; IRIBHN, Laboratoire d'Histologie, de Neuroanatomie et de; Neuropathologie and Service de Genetique Medicale, Universite; Libre de Bruxelles, Bruxelles, Belgium.
- CCR5 is the major coreceptor for macrophage-tropic strains of the human immunodeficiency virus type I (HIV-1). Homozygotes for a 32-base pair (bp) deletion in the coding sequence of the receptor (CCR5Delta32) were found to be highly resistant to viral infection, and CCR5 became, therefore, one of the paradigms illustr
- Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.
- Blood. 2000 Sep 1;96(5):1674-80. Unique Identifier : AIDSLINE MED/20417739
- Proost P; Menten P; Struyf S; Schutyser E; De Meester I; Van Damme J; Laboratory of Molecular Immunology, Rega Institute for Medical; Research, University of Leuven, Leuven, Belgium.; paul.kroost@rega.kuleuven.ac.be
- Chemokines are proinflammatory cytokines that play a role in leukocyte migration and activation. Recent reports showed that RANTES (regulated on activation normal T-cell expressed and secreted chemokine), eotaxin, macrophage-derived chemokine (MDC), and stromal cell-derived factor-1 (SDF-1) are NH(2)-terminally trunca
- Kinetics of CXCR4 and CCR5 up-regulation and human immunodeficiency virus expansion after antigenic stimulation of primary CD4(+) T lymphocytes.
- Blood. 2000 Sep 1;96(5):1853-6. Unique Identifier : AIDSLINE MED/20417763
- Maier R; Bartolome-Rodriguez MM; Moulon C; Weltzien HU; Meyerhans A; Department of Virology, Institute of Medical Microbiology and; Hygiene, Homburg, Germany.
- The chemokine receptors CCR5 and CXCR4 are coreceptors for the human immunodeficiency virus (HIV) and determine the cell tropism of different HIV strains. Previous studies on their regulation were performed under conditions of unspecific T-lymphocyte stimulation and provided conflicting results. To mimic physiologic c
- Mature dendritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4(+) and CD8(+) T lymphocyte responses.
- Blood. 2000 Sep 1;96(5):1857-64. Unique Identifier : AIDSLINE MED/20417764
- Herr W; Ranieri E; Olson W; Zarour H; Gesualdo L; Storkus WJ; Department of Surgery, University of Pittsburgh Medical Center,; Pittsburgh, PA, USA.
- Immunotherapy trials targeting the induction of tumor-reactive T-cell responses in cancer patients appear to hold significant promise. Because nonmutated lineage-specific antigens and mutated idiotypic antigens may be coexpressed by tumor cells, the use of autologous tumor material to promote the broadest range of ant
- Differentiation of myeloid dendritic cells into CD8alpha-positive dendritic cells in vivo.
- Blood. 2000 Sep 1;96(5):1865-72. Unique Identifier : AIDSLINE MED/20417765
- Merad M; Fong L; Bogenberger J; Engleman EG; Department of Pathology, Stanford University School of Medicine,; Stanford, CA, USA. meradm@leland.stanford.edu
- Bone marrow-derived dendritic cells (DC) represent a family of antigen-presenting cells (APC) with varying phenotypes. For example, in mice, CD8alpha(+) and CD8alpha(-) DC are thought to represent cells of lymphoid and myeloid origin, respectively. Langerhans cells (LC) of the epidermis are typical myeloid DC; they do
- Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection.
- Blood. 2000 Sep 1;96(5):1979-84. Unique Identifier : AIDSLINE MED/20417780
- Mastroianni CM; d'Ettorre G; Forcina G; Lichtner M; Mengoni F; D'Agostino C; Corpolongo A; Massetti AP; Vullo V; Department of Infectious and Tropical Diseases, La Sapienza; University, Rome, Italy. cm.mastroianni@tiscalinet.it
- Polymorphonuclear leukocyte (PMN) dysfunction has been reported in human immunodeficiency virus (HIV)-infected patients. Interleukin (IL)-15 is a recently discovered cytokine that potentiates antimicrobial functions of normal PMNs. We evaluated the in vitro effect of IL-15 on chemotaxis and fungicidal activity of PMNs
- Class I-unrestricted noncytotoxic anti-HTLV-I activity of CD8(+) T cells.
- Blood. 2000 Sep 1;96(5):1994-5. Unique Identifier : AIDSLINE MED/20417783
- Moriuchi M; Moriuchi H; Division of Medical Virology, Department of Molecular; Microbiology and Immunology, Nagasaki University Graduate School; of Medical Sciences, Nagasaki University School of Medicine,; Nagasaki, Japan.
- Although it is widely believed that viral clearance is mediated principally by the destruction of infected cells by cytotoxic T cells, noncytolytic antiviral activity of CD8(+) T cells may play a role in preventing the progression to disease in infections with immunodeficiency viruses and hepatitis B virus. We demonst
- Long-term patient adherence to antiretroviral therapy.
- Ann Pharmacother. 2000 Jun;34(6):703-9. Unique Identifier : AIDSLINE MED/20317710
- Ostrop NJ; Hallett KA; Gill MJ; Southern Alberta HIV Clinic, Foothills Medical Centre, Calgary,; Canada.
- OBJECTIVE: To measure patient adherence to antiretroviral therapy over a two-year period and to identify factors impacting adherence. METHODS: In a regional HIV treatment center, 100 consecutive patients starting any new antiretroviral agent were enrolled in this study, which consisted of a one-year retrospective data
- Psychological aspects of neuropathic pain.
- Clin J Pain. 2000 Jun;16(2 Suppl):S101-5. Unique Identifier : AIDSLINE MED/20326563
- Haythornthwaite JA; Benrud-Larson LM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins; University, Baltimore, Maryland, USA. jhaythor@welch.jhu.edu
- Studies on the psychosocial impact of neuropathic pain conditions, including postherpetic neuralgia, diabetic neuropathy, complex regional pain syndrome, post spinal cord injury, postamputation, and AIDS-related neuropathy, are reviewed. Although limited, data are consistent with the larger literature on chronic pain
- Neuropathic pain in cancer and AIDS.
- Clin J Pain. 2000 Jun;16(2 Suppl):S41-8. Unique Identifier : AIDSLINE MED/20326554
- Katz N; Pain Management Center, Brigham and Women's Hospital, Boston,; Massachusetts 02115, USA. nat@zeus.bwh.harvard.edu
- Neuropathic pain is highly prevalent in patients with cancer and patients with AIDS, has profound effects on ability to function and quality of life, and is undertreated. Multiple obstacles to the adequate treatment of pain in patients with cancer and AIDS have been identified. Specific factors relevant to neuropathic
- Clinical applications of capsaicinoids.
- Clin J Pain. 2000 Jun;16(2 Suppl):S86-9. Unique Identifier : AIDSLINE MED/20326561
- Robbins W; University of California, San Francisco, USA.; wendye_robbins@quickmail.ucsf.edu
- Capsaicinoids are molecules derived from chili peppers. They are best known for their pungency, producing mild to intense spice upon ingestion. It has long been known that peppers possess unusual qualities. Historically, they were burned in war rituals, and used to stimulate appetite. In 1997, a gene that encoded for
- Autoantibody reactivity in a case of Schnitzler's syndrome: evidence for a Th1-like response and detection of IgG2 anti-FcepsilonRIalpha antibodies.
- Int Arch Allergy Immunol. 2000 Aug;122(4):279-86. Unique Identifier : AIDSLINE MED/20428136
- Sperr WR; Natter S; Baghestanian M; Smolen J; Wolff K; Binder BR; Muller MR; Lechner K; Valenta R; Valent P; Department of Internal Medicine I, Division of Hematology and; Hemostaseology, University of Vienna, Austria.; wolfgang.r.sperr@univie.ac.at
- Schnitzler s syndrome is a rare disease characterized by chronic urticaria, monoclonal IgM, and clinical and laboratory signs of inflammation. In a subset of patients, the urticarial lesions cause pruritus. However, the pathophysiology of the disease and the biochemical basis of urticaria are not known. We describe a
- Induction of high levels of antibodies recognizing the neutralizing epitope ELDKWA and the D- or K-position-mutated epitopes by candidate epitope vaccines against HIV-1.
- Int Arch Allergy Immunol. 2000 Aug;122(4):287-92. Unique Identifier : AIDSLINE MED/20428137
- Xiao Y; Dong X; Chen Y; Laboratory of Immunology, Research Centre for Medical Science,; and School of Life Science and Engineering, Tsinghua University,; Beijing, People's Republic of China.
- Monoclonal antibody 2F5 recognizing the ELDKWA epitope on HIV-1 gp41 has a significant neutralization potency against 90% of the investigated viruses of African, Asian, American, and European strains, but the antibody responses to the epitope 2F5 in HIV-1-infected individuals were very low. We attempted to induce high
- Lessons for Canada. The 13th International AIDS Conference [news]
- Can Fam Physician. 2000 Sep;46:1922-3. Unique Identifier : AIDSLINE MED/20468100
- Dion H
- Antiviral chemoprophylaxis after occupational exposure to the human immunodeficiency virus (HIV) [letter]
- Natl Med J India. 1998 Sep-Oct;11(5):249. Unique Identifier : AIDSLINE MED/20451732
- Dada T; Kumar A
- [Bronchofibroscopy in the etiologic diagnosis of lung diseases in patients with acquired immunodeficiency syndrome]
- Rev Assoc Med Bras. 2000 Apr-Jun;46(2):174-6. Unique Identifier : AIDSLINE MED/20476932
- da Silva RM; Chterpensque A; Servico de Pneumologia, Universidade Federal de Santa Catarina,; Florianopolis.
- PURPOSE: To evaluate the role of bronchoscopy in diagnosis of pulmonary disease in acquired immunodeficiency syndrome. METHODS: This study analyses a group of 49 patients with AIDS diagnosis admitted at Nereu Ramos Hospital-Florianopolis-SC. It was selected patients with respiratory symptoms and radiologic signs of pu
- [Human immunodeficiency virus: current pregnancy aspects]
- Arch Pediatr. 2000 May;7 Suppl 2:295s-298s. Unique Identifier : AIDSLINE MED/20362375
- Mandelbrot L; Service gynecologie-obstetrique, hopital Cochin-Port-Royal,; Paris, France.
- [Antiretroviral drugs and pregnancy: apropos of an alert regarding mitochondrial pathology and nucleoside analogs]
- Arch Pediatr. 2000 May;7 Suppl 2:407s-408s. Unique Identifier : AIDSLINE MED/20362415
- Bavoux F; Loubeyre-Unique C; Blanche S; Centre regional de pharmacovigilance, hopital Saint-Vincent de; Paul, Paris, France.
- The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
- Eur J Neurosci. 2000 Aug;12(8):2839-46. Unique Identifier : AIDSLINE MED/20428266
- Gemignani A; Paudice P; Pittaluga A; Raiteri M; Department of Experimental Medicine, Pharmacology and Toxicology; Section, Viale Cembrano 4, 16148 Genova, Italy.
- The objective of this study was to investigate the effects of the HIV-1 envelope protein gp120 and its peptide fragments on the function of N-methyl-D-aspartate (NMDA) receptors mediating release of cholecystokinin (CCK) and somatostatin (SRIF). These are nonconventional NMDA receptors recently found to be activated b
- The two faces of HIV infection of cerebrospinal fluid.
- Trends Microbiol. 2000 Sep;8(9):387-91. Unique Identifier : AIDSLINE MED/20446425
- Price RW; Dept of Neurology, University of California San Francisco, San; Francisco, CA, USA. price@itsa.ucsf.edu
- The chimpanzee and other non-human-primate models in HIV-1 vaccine research.
- Trends Microbiol. 2000 Sep;8(9):426-31. Unique Identifier : AIDSLINE MED/20446436
- Nath BM; Schumann KE; Boyer JD; Dept of Pathology and Laboratory Medicine, University of; Pennsylvania, 505 Stellar Chance, 422 Curie Blvd, Philadelphia,; PA 19104, USA.
- Animal models are of great importance for the study of disease pathogenesis, particularly non-human-primate models of infectious diseases. The role of non-human primates in HIV-1 research is continually discussed and debated. Here, we examine three primate models: chimpanzee-HIV-1, rhesus macaque-simian immunodeficien
- Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.
- Immunity. 2000 Sep;13(3):365-74. Unique Identifier : AIDSLINE MED/20471517
- Ishido S; Choi JK; Lee BS; Wang C; DeMaria M; Johnson RP; Cohen GB; Jung JU; Tumor Virology Division, New England Regional Primate Research; Center, Harvard Medical School, Southborough, Massachusetts; 01772, USA.
- Kaposi s sarcoma-associated herpesvirus (KSHV) K3 and K5 proteins dramatically downregulate MHC class I molecules. However, although MHC class I downregulation may protect KSHV-infected cells from cytotoxic T lymphocyte recognition, these cells become potential targets for natural killer (NK) cell-mediated lysis. We n
- Poised for contagion: evolutionary origins of the infectious abilities of invertebrate retroviruses.
- Unique Identifier : AIDSLINE MED/20442525 P
- Malik HS; Henikoff S
- Genetically engineered fibroblasts with antigen-presenting capability: efficient induction of an antigen-specific cytotoxic T-lymphocyte response and protection against tumor development in vivo.
- Cancer Gene Ther. 2000 Jun;7(6):861-9. Unique Identifier : AIDSLINE MED/20336363
- Kim TS; Chung SW; Kim SH; Kang BY; Hwang SY; Lee JW; College of Pharmacy, Chonnam National University, Kwangju,; Republic of Korea. taekim@chonnam.chonnam.ac.kr
- BLK mouse fibroblasts (H-2b) were genetically engineered to express costimulatory B7.1 and interleukin-2 (BLK/IL2/B7.1). The BLK/IL2/B7.1 cells were then pulsed with an ovalbumin (OVA) epitope as a model antigen (Ag) (BLK/IL2/B7.1/OVA), and tested for the induction of OVA-specific cytotoxic T lymphocytes (CTLs) in C57
- [CD4 lymphopenia and postoperative immunosuppression in cardiac surgery]
- Cas Lek Cesk. 2000 Jun 21;139(12):361-8. Unique Identifier : AIDSLINE MED/20409526
- Kunes P; Krejsek J; Kardiochirurgicka klinika LF UK a FN, Hradec Kralove.
- The diversity and heterogeneity of biologic reactions is a condition sine qua non for the adaptation of live organisms to changes of external environment. Reactions of the immune system enable survival even in extreme conditions. Modern medicine often reaches situations never met by the organism in phylogenesis. Thank
- Plasma HIV-1 RNA quantitation in HIV infected adult Zimbabweans.
- Cent Afr J Med. 1999 Sep;45(9):231-4. Unique Identifier : AIDSLINE MED/20470978
- Chaka WS; Sibanda EN; University of Zimbabwe Medical School, Harare, Zimbabwe.; immunolo@harare.iafrica.com
- OBJECTIVES: To determine HIV-1 RNA levels in plasma of HIV infected Zimbabwean adults and to correlate these with CD4+ cell counts. DESIGN: Prospective observational study. SETTING: Specialist Immunology Laboratory, Harare, Zimbabwe. SUBJECTS: 49 consecutive HIV infected patients. MAIN OUTCOME MEASURES: CD4+ cell coun
- Post natal maternal morbidity patterns in mothers delivering in Gweru City (Midlands province).
- Cent Afr J Med. 1999 Sep;45(9):234-9. Unique Identifier : AIDSLINE MED/20470979
- Zishiri C; Shodu LK; Tshimanga M; Nyirongo L; Ministry of Health and Child Welfare, Harare, Zimbabwe.
- OBJECTIVES: To determine morbid conditions suffered by mothers during the first six weeks post delivery and risk factors associated with them in Gweru district. DESIGN: A cross sectional survey. SETTING: Gweru district hospital, Monomotapa, Mkoba 1 and Mkoba polyclinic. SUBJECTS: A consecutive sample of 201 mothers re
- Low CD4 count in HIV negative malaria cases and normal CD4 count in HIV positive and malaria negative patients [letter]
- Cent Afr J Med. 1999 Sep;45(9):248. Unique Identifier : AIDSLINE MED/20470983
- Chirenda J
- Canadian consensus conference on the management of viral hepatitis. Canadian Association for the Study of the Liver.
- Can J Gastroenterol. 2000 Jul-Aug;14 Suppl B:5B-20B. Unique Identifier : AIDSLINE MED/20398386
- These proceedings of a consensus conference on the management of viral hepatitis were sponsored by the Canadian Association for Study of the Liver (CASL) and Health Canada . Experts in various aspects of viral hepatitis presented a review of the medical literature on assigned topics
- A step toward putting a genie back in its bottle [letter]
- CMAJ. 2000 Sep 5;163(5):495. Unique Identifier : AIDSLINE MED/20462017
- Parker JE
- Prevention of perinatal transmission of HIV infection [letter]
- CMAJ. 2000 Oct 3;163(7):831-2. Unique Identifier : AIDSLINE MED/20487954
- Robinson JL; Lee BE
- Preventing mother to child transmission of HIV: the role of caesarean section [editorial]
- Sex Transm Infect. 2000 Aug;76(4):231-2. Unique Identifier : AIDSLINE MED/20478946
- Read JS
- The significance of oral health in HIV disease.
- Sex Transm Infect. 2000 Aug;76(4):236-43. Unique Identifier : AIDSLINE MED/20478948
- Chapple IL; Hamburger J; Unit of Periodontology, School of Dentistry, University of; Birmingham.
- A longitudinal study of HPV detection and cervical pathology in HIV infected women.
- Sex Transm Infect. 2000 Aug;76(4):257-61. Unique Identifier : AIDSLINE MED/20478951
- Cubie HA; Seagar AL; Beattie GJ; Monaghan S; Williams AR; Regional Clinical Virology Laboratory, Lothian University; Hospitals NHS Trust. heather.cubie@ed.ac.uk
- OBJECTIVE: To monitor the presence and persistence of high risk (HR) human papillomavirus (HPV) in cervical brushings from HIV infected women. METHODS: Prospective observational cohort study of HIV infected women. Women were enrolled from the cohort of 164 HIV infected women who attend the colposcopy clinic at the Edi
- Herpesvirus infection of eye and brain in HIV infected patients.
- Sex Transm Infect. 2000 Aug;76(4):282-6. Unique Identifier : AIDSLINE MED/20478956
- Miller RF; Howard MR; Frith P; Perrons CJ; Pecorella I; Lucas SB; Department of Sexually Transmitted Diseases, Windeyer Institute; of Medical Sciences, Royal Free and University College Medical; School, Mortimer Market Centre, London. rmiller@gum.ucl.ac.uk
- OBJECTIVES: To compare histological with genome detection methods for diagnosis of herpesvirus infection in eye and brain of HIV infected patients undergoing necropsy and to correlate these findings with both antemortem clinical findings and postmortem evidence of extraocular herpesvirus infection, especially in the C
- HIV, sexually transmitted infections, and risk behaviours in male commercial sex workers in Sydney.
- Sex Transm Infect. 2000 Aug;76(4):294-8. Unique Identifier : AIDSLINE MED/20478959
- Estcourt CS; Marks C; Rohrsheim R; Johnson AM; Donovan B; Mindel A; Sexually Transmitted Infections Research Centre, University of; Sydney, Australia. Claudia.Escourt@royalhos-tr.nthames.nhs.uk
- OBJECTIVES: To assess prevalence of HIV and sexually transmitted infections (STIs), risk behaviours, and demographics in male commercial sex workers (CSWs)/prostitutes in Sydney. METHODS: Retrospective, cross sectional study with two comparison groups. Demographic, behavioural, and morbidity data were analysed from st
- Screening for HIV infection in genitourinary medicine clinics: a lost opportunity? British Co-operative Clinical Group.
- Sex Transm Infect. 2000 Aug;76(4):307-10. Unique Identifier : AIDSLINE MED/20478962
- OBJECTIVES: To examine the policy and practice of HIV testing in genitourinary medicine clinics in the United Kingdom . DESIGN: All 176 consultants in charge of genitourinary medicine clinics in the United Kingdom were sent a policy and practice questionnaire. A self selected group of 5
- Seroprevalence of syphilis among women attending urban antenatal clinics in Burkina Faso, 1995-8. The DITRAME Study Group. DIminunation de la TRAnsmission Mere-Enfant.
- Sex Transm Infect. 2000 Aug;76(4):314-6. Unique Identifier : AIDSLINE MED/20478964
- Sombie I; Meda N; Cartoux M; Tiendrebeogo S; Ouangre A; Yaro S; Ky-Zerbo O; Dao B; Van de Perre P; Mandelbrot L; Dabis F; Centre MURAZ, Organisation de Coordination et de Cooperation; pour la lutte contre les Grandes Endemies (OCCGE),; Bobo-Dioulasso, Burkina Faso.
- OBJECTIVES: To describe annual trends in syphilis seroprevalence and to identify risk factors of syphilis among pregnant women receiving antenatal care in Bobo-Dioulasso, Burkina Faso . METHODS: Women were recruited between January 1995 and July 1998 in three antenatal clinics wher
- Sexual co-transmission of HIV, hepatitis B, and hepatitis C viruses.
- Sex Transm Infect. 2000 Aug;76(4):317. Unique Identifier : AIDSLINE MED/20478965
- Singh S; Thappa DM; Jaisankar TJ; Sujatha S; Department of Dermatology and STD, JIPMER, Pondicherry, India.
- Cheilitis in association with indinavir [letter]
- Sex Transm Infect. 2000 Aug;76(4):323-4. Unique Identifier : AIDSLINE MED/20478976
- Fox PA; Hawkins PA; Staughton RC
- Twenty-five years of tuberculosis in a French university hospital: a laboratory perspective.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):504-12. Unique Identifier : AIDSLINE MED/20320176
- Robert J; Trystram D; Truffot-Pernot C; Cambau E; Jarlier V; Grosset J; Laboratoire de Bacteriologie et Hygiene, Groupe Hospitalier; Pitie-Salpetriere, Paris, France. jrobert@chups.jussieu.fr
- OBJECTIVE: To determine the impact of recent changes in the epidemiology of tuberculosis in France and other industrialised countries on the primary trends of tuberculosis case rates in a French university hospital. DESIGN: Descriptive study of all 4549 culture-positive tuberculosi
- Trial-of-antibiotic algorithm for the diagnosis of tuberculosis in a district hospital in a developing country with high HIV prevalence.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):513-8. Unique Identifier : AIDSLINE MED/20320177
- Wilkinson D; Newman W; Reid A; Squire SB; Sturm AW; Gilks CF; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Hlabisa, South Africa.; david.wilkinson@unisa.edu.au
- OBJECTIVE: To evaluate a diagnostic algorithm for pulmonary tuberculosis based on smear microscopy and objective response to trial of antibiotics. SETTING: Adult medical wards, Hlabisa Hospital, South Africa , 1996-1997. METHODS: Adults with chronic chest symptoms and abnormal ches
- HIV testing among tuberculosis patients in the era of antiretroviral therapy: a population-based study in Brazil.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):519-27. Unique Identifier : AIDSLINE MED/20320178
- DeRiemer K; Soares EC; Dias SM; Cavalcante SC; Division of Public Health Biology and Epidemiology, School of; Public Health, University of California, Berkeley, USA.
- SETTING: Rio de Janeiro, Brazil , a city with 29862 cases of tuberculosis (TB) reported between January 1995 and June 1998. OBJECTIVES: To evaluate the counseling and testing practices for human immunodeficiency virus (HIV) infection among TB patients, and to identify the patient ch
- Quantitative sputum bacillary load during rifampin-containing short course chemotherapy in human immunodeficiency virus-infected and non-infected adults with pulmonary tuberculosis.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):528-36. Unique Identifier : AIDSLINE MED/20320179
- Joloba ML; Johnson JL; Namale A; Morrissey A; Assegghai AE; Mugerwa RD; Ellner JJ; Eisenach KD; Department of Medical Microbiology, Makerere University, Kampala,; Uganda. mlj10@po.cwru.edu
- SETTING: National Tuberculosis (TB) Treatment Centre, Mulago Hospital and Joint Clinical Research Centre, Kampala, Uganda . OBJECTIVE: To compare the quantitative sputum bacillary load between TB patients infected with the human immunodeficiency virus (HIV) and those non-infected, d
- Human immunodeficiency virus-related tuberculosis and primary drug resistance in Bangkok, Thailand.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):537-43. Unique Identifier : AIDSLINE MED/20320180
- Punnotok J; Shaffer N; Naiwatanakul T; Pumprueg U; Subhannachart P; Ittiravivongs A; Chuchotthaworn C; Ponglertnapagorn P; Chantharojwong N; Young NL; Limpakarnjanarat K; Mastro TD; Central Chest Hospital, Department of Communicable Disease; Control, Ministry of Public Health, Nonthaburi, Thailand.
- SETTING: Central Chest Hospital, a 500-bed referral hospital near Bangkok with a large out-patient department. OBJECTIVES: To determine human immunodeficiency virus (HIV) seroprevalence among patients with pulmonary tuberculosis (TB), and compare HIV-positive and HIV-negative TB patients. DESIGN: From July 1995 throug
- DNA fingerprinting of a national sample of Mycobacterium tuberculosis isolates, Botswana, 1995-1996.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):584-7. Unique Identifier : AIDSLINE MED/20320188
- Lockman S; Sheppard JD; Mwasekaga M; Kenyon TA; Binkin NJ; Braden CR; Woodley CL; Rumisha DW; Tappero JW; Division of TB Elimination, National Centers for HIV/AIDS, STD; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.
- DNA fingerprinting may be useful to elucidate tuberculosis (TB) transmission in community settings, but its utility is limited if only few fingerprint patterns are observed or band numbers are low. We performed DNA fingerprinting on a national, population-based sample of Mycobacterium tuberculosis isolates from
- Study of the in vitro susceptibility of M. tuberculosis to ofloxacin in Spain. Spanish Study Group of M. tuberculosis resistance.
- Int J Tuberc Lung Dis. 2000 Jun;4(6):588-91. Unique Identifier : AIDSLINE MED/20320189
- Casal M; Ruiz P; Herreras A; Mycobacteria Reference Laboratory, Cordoba, Spain.; mi3relur@lucano.uco.es
- The aim of this study was to determine the proportion of antituberculosis ofloxacin resistance among Mycobacterium tuberculosis strain isolates in Spain . Over a period of one month, 213 M. tuberculosis strains collected from 14 different hospitals were studied, including strains bot
- Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).
- Curr Med Chem. 2000 Oct;7(10):995-1039. Unique Identifier : AIDSLINE MED/20381423
- Parang K; Wiebe LI; Knaus EE; Department of Pharmacology and Molecular Sciences, 317 Hunterian,; School of Medicine, 725 North Wolfe Street, Johns Hopkins; University, Baltimore, Maryland 21205-2185, USA.; kayparang@hotmail.com
- 3 -Azido-2 ,3 -dideoxythymidine ( AZT , 1, zidovudine, RetrovirTM) is used to treat patients with human immunodeficiency virus (HIV) infection. AZT, after conversion to AZT-5 -triphosphate (AZT-TP) by cellular enzymes, inhibits HIV-reverse transcriptase
- Monoclonal TCR mRNA transcripts are preferentially detected in the TCR variable alpha chain in CD8(+) T-lymphocytes: implications for immunomonitoring.
- Int J Mol Med. 1999 Feb;3(2):139-44. Unique Identifier : AIDSLINE MED/20465707
- Hohn H; Reichert T; Neukirch C; Pilch H; Maeurer MJ; Department of Medical Microbiology, Johannes Gutenberg; University, Mainz, Germany.
- Clinical trials have started to implement tumor-associated antigens in the form of antigenic peptides in order to augment CD8(+) T-cell responses directed against autologous cancer cells. One of the surrogate markers for successful immunization is the characterization of T-lymphocytes reacting to the immunizing peptid
- Exchangeability of accessory Vif and Vpu proteins between various HIV/SIVs (review).
- Unique Identifier : AIDSLINE MED/20465716
- Adachi A; Iida S; Fukumori T; Tamaki M; Inubushi R; Shimano R; Oshima Y; Akari H; Koyama AH
- Representative human and simian immunodeficiency viruses (HIV/SIVs) have been monitored for their Vif and Vpu activities in a wide variety of cells. In contrast to the prototype HIV-1, viruses of the other groups do not necessarily have these activities. Only HIV-2 and SIVmnd were clearly demonstrated to show the Vif
- Rev-dependent expression of three species of HIV-1 mRNAs (review).
- Int J Mol Med. 1999 Mar;3(3):297-302. Unique Identifier : AIDSLINE MED/20465729
- Fukumori T; Kagawa S; Iida S; Oshima Y; Akari H; Koyama AH; Adachi A; Department of Urology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.
- The expression of structural and accessory genes of human immunodeficiency virus type 1 (HIV-1) except for nef requires a viral regulatory protein Rev. Rev-dependency of the expression of structural (gag, pol and env), regulatory (tat and rev), and accessory genes (vif, vpr, vpu and nef) has been investigated by vario
- Activation of HIV-1 enhancer sequence by vaccinia virus.
- Int J Mol Med. 1999 Mar;3(3):311-3. Unique Identifier : AIDSLINE MED/20465732
- Adachi A; Oshima Y; Koyama AH; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.
- To investigate whether vaccinia virus (VV) can augment gene expression of human immunodeficiency virus type 1 (HIV-1), co-transfection experiments were carried out in which recombinant plasmids containing various portions of the HIV-1 long terminal repeat (LTR) linked to the chloramphenicol acetyltransferase (CAT) gen
- Oral AIDS vaccine to be tested in the Republic of Uganda [news]
- Bull World Health Organ. 2000;78(7):945-6. Unique Identifier : AIDSLINE MED/20449725
- Gottlieb S
- UNAIDS estimates that half the teenagers in some African countries will die of AIDS [news]
- Bull World Health Organ. 2000;78(7):946. Unique Identifier : AIDSLINE MED/20449726
- Whyte B
- Nelson Mandela calls for unity at the XIIIth International AIDS Conference in Durban, South Africa [news]
- Bull World Health Organ. 2000;78(9):1169. Unique Identifier : AIDSLINE MED/20470976
- Whyte B
- Vaccines in historic evolution and perspective: a narrative of vaccine discoveries.
- Unique Identifier : AIDSLINE MED/20307064
- Hilleman MR
- The sciences of vaccinology and immunology were created only two centuries ago by Jenner s scientific studies of prevention of smallpox through inoculation with cowpox virus. This rudimentary
- How does HIV induce AIDS? The virus protein hypothesis.
- J Hum Virol. 2000 Mar-Apr;3(2):81-2. Unique Identifier : AIDSLINE MED/20307066
- Denner J; Paul-Ehrlich-Institut, Langen, Germany. denjo@pei.de
- The genome, the structural and regulatory proteins of HIV-1, as well as the clinical course of the disease it induces are well studied. Despite this knowledge, it is still unknown how the virus induces AIDS. The disease is characterized by opportunistic infections based on a generalized and nonspecific immunosuppressi
- Is AIDS vaccine research at a turning point?
- J Hum Virol. 2000 Mar-Apr;3(2):83-7. Unique Identifier : AIDSLINE MED/20307067
- Levy JP; Institut Cochin de Genetique Moleculaire, INSERM IFR 18, CNRS; FR 20, Paris, France. levy@cochin.inserm.fr
- Although initial anti-ENV vaccines have failed, better results may be obtained with non-ENV vaccines capable of inducing cell-mediated responses and perhaps mucosal reactions. A turning point in AIDS vaccine research has been reached in that there are three precise questions to answer: 1. Are the protections obtaine
- 1999: a time to re-evaluate AIDS vaccine strategies.
- Unique Identifier : AIDSLINE MED/20307068
- Ruprecht RM; Hofmann-Lehmann R; Rasmussen RA; Vlasak J; Xu W; Dana-Farber Cancer Institute and Harvard Medical School, Boston,; Massachusetts 02115, USA. ruth_ruprecht@dfci.harvard.edu
- The field of AIDS vaccine development is in flux. Important new findings were reported in 1999 that led to a rethinking of AIDS vaccine strategies. We have been given the challenging task of providing an overview. Rather than attempting to provide a comprehensive summary, we will restrict our discussion to a few major
- Antibody spectrum against the viral transactivator protein in patients with human immunodeficiency virus type 1 infection and Kaposi's sarcoma.
- J Hum Virol. 2000 May-Jun;3(3):137-43. Unique Identifier : AIDSLINE MED/20337841
- Demirhan I; Chandra A; Mueller F; Mueller H; Biberfeld P; Hasselmayer O; Chandra P; Gustav-Embden Center of Biological Chemistry, Department of; Molecular Biology, Frankfurt University Medical School, Germany.
- We analyzed patterns of antibody response to recombinant transactivator protein (human Immunodeficiency virus type 1 [HIV-1] tat) in serum samples from HIV-1-negative subjects (n = 60), HIV-1-infected asymptomatic patients (n = 20), HIV-1-infected patients with Kaposi s sarcoma (n = 25), and patients with Kaposi s sar
- Deletions in the beta3-beta4 hairpin loop of HIV-1 reverse transcriptase are observed in HIV-1 isolated from subjects during long-term antiretroviral therapy.
- J Hum Virol. 2000 May-Jun;3(3):144-9. Unique Identifier : AIDSLINE MED/20337842
- Ross L; Johnson M; Ferris RG; Short SA; Boone LR; Melby TE; Lanier R; Shaefer M; St. Clair M; Department of Virology, Glaxo Wellcome Inc., Research Triangle; Park, North Carolina 27709, USA. llr8156@glaxowellcome.com
- OBJECTIVES: To examine the effect of in-frame deletions in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on plasma viremia and phenotypic resistance to antiretroviral drugs. STUDY DESIGN/METHODS: Plasma HIV-1 RNA was isolated from 168 antiretroviral therapy-experienced subjects for quantificat
- Single- and multidrug resistance mutations to reverse transcriptase and protease inhibitors: human immunodeficiency virus type 1-infected patients from two geographical areas in Spain. Spanish Groups for Antiretroviral Resistance Studies.
- J Hum Virol. 2000 May-Jun;3(3):150-6. Unique Identifier : AIDSLINE MED/20337843
- Perez-Alvarez L; Villahermosa ML; Cuevas MT; Delgado E; Manjon N; Vazquez de Parga E; Medrano L; Contreras G; Thomson MM; Colomo C; Taboada JA; Najera R; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, Madrid, Spain.
- OBJECTIVES: To describe the prevalence of genotypic resistance mutations, including single and multidrug resistance (MDR) to reverse transcriptase (RT) and protease (PR) inhibitors in treated and untreated patients from two geographical areas in Spain (Madrid and Galicia). STUDY DES
- Molecular evolution of human immunodeficiency virus type 1 subtype A in Senegal: 1988-1997.
- J Hum Virol. 2000 May-Jun;3(3):157-64. Unique Identifier : AIDSLINE MED/20337844
- Sankale JL; Hamel D; Woolsey A; Traore T; Dia TC; Gueye-Ndiaye A; Essex M; Mboup T; Kanki P; Department of Immunology, and Infectious Diseases, Harvard School; of Public Health and Harvard AIDS Institute, Boston,; Massachusetts 02115, USA.
- OBJECTIVE: Few studies have been able to track the genetic diversity of HIV-1 viruses in human populations over time. We analyzed the molecular evolution of subtype A over a 10-year period, in a cohort of female sex workers with a known time of infection. STUDY DESIGN/METHODS: We amplified and sequenced the C2-V3 regi
- Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core.
- J Hum Virol. 2000 May-Jun;3(3):165-72. Unique Identifier : AIDSLINE MED/20337845
- Zhang H; Dornadula G; Orenstein J; Pomerantz RJ; The Dorrance H. Hamilton Laboratories, Center for Human Virology,; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.
- INTRODUCTION: In the past, retroviral endogenous reverse transcription (ERT) was considered an artificial process, secondary to permeabilization of the viral envelope by detergents or amphipathic peptides. However, recently we have demonstrated that ERT may occur in a variety of lentiviruses without detergent treatmen
- Early detection of neurophysiological abnormalities in infection by human immunodeficiency virus.
- Clin Electroencephalogr. 2000 Apr;31(2):116-21. Unique Identifier : AIDSLINE MED/20299673
- Aznar-Bueno C; Abad-Alegria F; Amiguet JA; Clinical Neurophysiology Service, Hospital Clinico Universitario,; Zaragoza, Spain.
- The human immunodeficiency virus causes serious, progressive and irreversible deterioration of the immunocompetence system and of the nervous system, so neurological pathology in infected patients is frequent (30-40%), affecting both the central and the peripheral nervous systems. There are different clinical and labo
- Cerebral infarction in adult AIDS patients: observations from the Edinburgh HIV Autopsy Cohort.
- Stroke. 2000 Sep;31(9):2117-26. Unique Identifier : AIDSLINE MED/20433491
- Connor MD; Lammie GA; Bell JE; Warlow CP; Simmonds P; Brettle RD; Neurology Unit, Department of Medicine, University of the; Witwatersrand, Johannesburg, South Africa.
- BACKGROUND AND PURPOSE: Autopsy series of patients with AIDS have found a 4% to 29% prevalence of cerebral infarction. Little is known of the prevalence of cerebral infarction when not associated with non-HIV central nervous system (CNS) infection, lymphoma, or cardioembolic sources. Clinical correlation has seldom be
- [Central nervous system tuberculosis with and without HIV infection--clinical, neuroimaging, and neuropathological study]
- Rinsho Shinkeigaku. 2000 Mar;40(3):209-17. Unique Identifier : AIDSLINE MED/20343761
- Kurisaki H; Department of Neurology, National Tokyo Hospital.
- Clinical data, neuroimaging, and neuropathology of 17 patients with central nervous system tuberculosis were reported. Of this population, 12 were men, 5, women; ages ranged from 23 to 75 years (mean, 46.9). There were three HIV positive patients among them. More than a half of patients had disturbance of consciousnes
- [CNS cryptococcosis with idiopathic CD4+ T lymphocytopenia]
- Rinsho Shinkeigaku. 2000 Mar;40(3):249-53. Unique Identifier : AIDSLINE MED/20343768
- Watanabe H; Inukai A; Doyu M; Sobue G; Department of Neurology, Nagoya University School of Medicine.
- A 33-year-old Japanese man, with a history of recurrent skin cryptococcosis, was admitted complaining of fever and severe headache for 3 weeks. He had no known risk factors for human immunodeficiency virus (HIV) infection. Cerebrospinal fluid examination revealed an elevated opening pressure of 32 cm H2O, cell counts
- [A case of HTLV-I associated myelopathy with abnormal patchy MRI lesions in the spinal cord]
- Rinsho Shinkeigaku. 2000 Mar;40(3):254-8. Unique Identifier : AIDSLINE MED/20343769
- Yanagihara C; Nakaji K; Nishimura Y; Department of Neurology, Nishi-Kobe Medical Center, Japan.
- We report a case of HTLV-I associated myelopathy (HAM) with a spinal cord MRI showing abnormal multifocal and patchy lesions. A 50-year-old woman suffering from progressive paraparesis was admitted to our hospital. HTLV-I antibodies in the serum and CSF were positive, and a diagnosis of HAM was made. Her T2 weighted s
- Modified wick method using Weck-Cel sponges for collection of human rectal secretions and analysis of mucosal HIV antibody.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):297-309. Unique Identifier : AIDSLINE MED/20469952
- Kozlowski PA; Lynch RM; Patterson RR; Cu-Uvin S; Flanigan TP; Neutra MR; GI Cell Biology Research Laboratory, Department of Medicine,; Children's Hospital, Harvard Medical School, Boston,; Massachusetts, USA.
- Weck-Cel sponges were examined for suitability as an absorbent material for nontraumatic collection of rectal secretions in humans. Sponges were tested in vitro and determined by quantitative enzyme-linked immunosorbent assay (ELISA) to be capable of releasing 100% of absorbed albumin and all immunoglobulin subtypes a
- Absence of association between individual thymidine analogues or nonnucleoside analogues and lipid abnormalities in HIV-1-infected persons on initial therapy.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):310-5. Unique Identifier : AIDSLINE MED/20469953
- Matthews GV; Moyle GJ; Mandalia S; Bower M; Nelson M; Gazzard BG; Chelsea and Westminster Hospital, London, U.K.; gm@moyleg.demon.co.uk
- Changes in levels of triglycerides and cholesterol during antiretroviral therapy raise concerns regarding an increased future risk of atherogenic disease and may precede the appearance of fat redistribution. Hypotheses regarding the impact of nucleoside analogues on adipocytes provide a possible explanation for metabo
- Differences between women and men in adverse events and CD4+ responses to nucleoside analogue therapy for HIV infection. The Aids Clinical Trials Group 175 Team.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):316-24. Unique Identifier : AIDSLINE MED/20469954
- Currier JS; Spino C; Grimes J; Wofsy CB; Katzenstein DA; Hughes MD; Hammer SM; Cotton DJ; University of California Los Angeles, Los Angeles, California;; Harvard School of Public Health, Boston, Massachusetts, USA.; jscurrier@mednet.ucla.edu
- OBJECTIVE: To prospectively examine differences in baseline characteristics and study outcomes between HIV-infected women and men during a clinical trial of nucleoside analogue therapy. METHODS: ACTG 175 randomized HIV-infected patients with CD4+ counts between 200 and 500 cells/mm3 to one of four nucleoside analogue
- Effects of lipolysis or heat treatment on HIV-1 provirus in breast milk.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):325-9. Unique Identifier : AIDSLINE MED/20469955
- Chantry CJ; Morrison P; Panchula J; Rivera C; Hillyer G; Zorilla C; Diaz C; Department of Pediatrics, University of California Davis,; Sacramento, California, USA. caroline.chantry@ucdmc.ucdavis.edu
- BACKGROUND: Transmission of HIV-1 infection through breastfeeding is associated with integrated DNA (provirus) in milk cells. Reduction of HIV-1 DNA in milk may lessen infectivity. PURPOSE: To investigate efficacy of two methods available in developing countries to reduce HIV-1 proviral DNA in breast milk. METHODS: Me
- Cell-free virus in breast milk of HIV-1-seropositive women.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):330-6. Unique Identifier : AIDSLINE MED/20469956
- Pillay K; Coutsoudis A; York D; Kuhn L; Coovadia HM; Departments of Paediatrics and Child Health, and Department of; Virology, University of Natal, Durban, South Africa.
- To examine the prevalence, quantification, and factors that influence HIV in the cell-free compartment of breast milk, we performed reverse transcription polymerase chain reaction (RT-PCR) on samples obtained from HIV-1-infected study subjects. Virus was detected in 86 of 136 samples (63.2%) from 79 study subjects. HI
- Reduced toxicity with gradual initiation of trimethoprim-sulfamethoxazole as primary prophylaxis for Pneumocystis carinii pneumonia: AIDS Clinical Trials Group 268.
- Unique Identifier : AIDSLINE MED/20469957
- Para MF; Finkelstein D; Becker S; Dohn M; Walawander A; Black JR
- Trimethoprim-sulfamethoxazole (TMP/SMX) is recognized as the superior agent for Pneumocystis carinii pneumonia (PCP) prophylaxis but a high incidence of adverse drug reactions, which may be due to toxic drug metabolites, limits its use. AIDS Clinical Trials Group protocol 268 was a randomized, double-blind, controlled
- Oral ganciclovir systemic exposure is enhanced in HIV-infected patients with diarrhea and weight loss.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):344-51. Unique Identifier : AIDSLINE MED/20469958
- Mouly S; Aymard G; Diquet B; Caulin C; Bergmann JF; Department of Internal Medicine, Lariboisiere Hospital; and; Laboratory of Pharmacology, La Salpetriere Hospital, Paris,; France. smouly@email.unc.edu
- OBJECTIVE: To determine whether diarrhea and intestinal malabsorption during HIV infection alter oral ganciclovir systemic exposure. METHODS: We studied the oral disposition of ganciclovir in 42 HIV-infected patients stratified into three groups: A (n = 15), HIV (stage A and B); B (n = 13), AIDS (stage C); and C (n =
- Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):352-62. Unique Identifier : AIDSLINE MED/20469959
- Kirschner D; Webb GF; Cloyd M; Department of Microbiology and Immunology, The University of; Michigan Medical School, Ann Arbor, Michigan, USA.; kirschne@umich.edu
- Several proposed theories have described the progression of HIV infection. Even so, no concrete evidence supports any as comprehensive, including, for example, why the CD4+ T-cell counts fall from 1000/mm3 of blood to roughly 100/mm3 over an average 10-year period, whereas concomitant viral loads are relatively consta
- Obtaining HIV test results with a home collection test kit in a community telephone sample.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):363-8. Unique Identifier : AIDSLINE MED/20469960
- Osmond DH; Catania J; Pollack L; Canchola J; Jaffe D; MacKellar D; Valleroy L; Department of Epidemiology and Biostatistics, AIDS Research; Institute and Center for AIDS Prevention Studies, and Department; of Medicine, University of California, San Francisco, San; Francisco, California, USA. dosmond@psg.ucsf.edu
- OBJECTIVES: To test the feasibility of obtaining HIV test results by home collection kit from a probability telephone sample of men who have sex with men (MSM). METHODS: A quota sample of 615 MSM previously interviewed by the Urban Men s Health Study phone survey in Chicago, Los Angeles, New York City, and San Francis
- Cost-effective use of nevirapine to prevent vertical HIV transmission in sub-Saharan Africa.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):369-77. Unique Identifier : AIDSLINE MED/20469961
- Stringer JS; Rouse DJ; Vermund SH; Goldenberg RL; Sinkala M; Stinnett AA; Department of Obstetrics and Gynecology, School of Medicine,; University of Alabama at Birmingham, Birmingham, USA.; stringer@uab.edu
- OBJECTIVE: To assess the cost-effectiveness of alternative strategies of nevirapine (NVP) administration to prevent vertical HIV transmission in sub-Saharan Africa. DESIGN: A decision-analysis model was constructed to estimate the costs and effects of
- Clinical spectrum, morbidity, and mortality of acquired immunodeficiency syndrome in Taiwan: a 5-year prospective study.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):378-85. Unique Identifier : AIDSLINE MED/20469962
- Hung CC; Chen MY; Hsieh SM; Sheng WH; Chang SC; W.-H. Sheng is currently affiliated with the Department of; Internal Medicine, Tao-Yuan Hospital of the Department of Health,; Tao-Yuan County, Taiwan. hcc0401@ha.mc.ntu.edu.tw
- The clinical spectrum of AIDS and changes of morbidity and mortality associated with HIV infection following initiation of highly active antiretroviral therapy (HAART) are rarely described in the less developed countries in the Asia-Pacific region. We prospectively observed on a follow-up basis 309 HIV-infected patien
- High-risk behaviors during incarceration in African-American men treated for HIV at three Los Angeles public medical centers.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):386-92. Unique Identifier : AIDSLINE MED/20469963
- Wohl AR; Johnson D; Jordan W; Lu S; Beall G; Currier J; Kerndt PR; HIV Epidemiology Program, Los Angeles County Department of Health; Services, Los Angeles, CA, USA. awohl@dhs.co.la.ca.us
- OBJECTIVES: This paper describes research that examined the association between high-risk sexual and drug-using behaviors during incarceration and HIV infection for African-American men receiving HIV care at three public medical centers in Los Angeles County (LAC), California. METHODS: A case-control study was conduct
- Anal sex among HIV-seronegative women at high risk of HIV exposure. The HIVNET Vaccine Preparedness Study 2 Protocol Team.
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):393-8. Unique Identifier : AIDSLINE MED/20469964
- Gross M; Holte SE; Marmor M; Mwatha A; Koblin BA; Mayer KH; Abt Associates Inc., Cambridge, Massachusetts, and Bethesda,; Maryland, USA. michael@scharp.org
- To assess the prevalence and the sociodemographic and behavioral correlates of anal sex in a cohort of HIV-seronegative U.S. women at high risk of HIV exposure, we administered a risk assessment using audio computer-assisted self-interview (A-CASI). Of 1268 sexually active women, 432 (32%) reported anal sex in the pre
- Effects of CCR5 genetic polymorphism and HIV-1 subtype in antiretroviral response in Brazilian HIV-1-infected patients [letter]
- J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):399-400. Unique Identifier : AIDSLINE MED/20469965
- Accetturi CA; Pardini R; Novaes Pinto GH; Turcato G Jr; Lewi DS; Diaz RS
- Patterns of expression of viral and cytokine gene transcripts during mouse polyoma virus infection.
- Comb Chem High Throughput Screen. 2000 Aug;3(4):329-41. Unique Identifier : AIDSLINE MED/20432627
- Drake DR 3rd; Knoepp L; Lukacher AE; Actor JK; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322, USA.
- CD8(+) cytotoxic T lymphocytes are critical for clearance of infection and prevention of tumors caused by mouse polyoma virus. High susceptibility to polyoma-induced tumors is manifested by neonatal inoculation of mice belonging to particular H-2(k) haplotype inbred strains. We previously reported that tumor-susceptib
- 3rd International Workshop on Salvage Therapy for HIV Infection. 12-14 April 2000, Chicago, Illinois, USA. Report and Abstracts.
- Antivir Ther. 2000;5 Suppl 2:vii-xii, 1-35. Unique Identifier : AIDSLINE MED/20484504
- Involvement of the fas system in hepatitis C virus recurrence after liver transplantation.
- Unique Identifier : AIDSLINE MED/20436323
- Crespo J; Rivero M; Mayorga M; Fabrega E; Casafont F; Gomez-Fleitas M; Pons-Romero F
- To date, there have been no reports of the involvement of the Fas system in recurrent hepatitis C virus (HCV) infection after orthotopic liver transplantation (OLT). In 25 patients who underwent OLT for HCV-related liver cirrhosis, we evaluated the expression of the Fas antigen (FasAg) on hepatocytes, apoptic hepatocy
- Globin gene therapy: one (seemingly) small vector change, one giant leap in optimism.
- Unique Identifier : AIDSLINE MED/20407620
- Bodine D; National Human Genome Research Institute, National Institutes of; Health, 49 Convent Drive, MSC 4442, Bethesda, Maryland; 20892-4442, USA. tedyaz@nchgr.nih.gov
- A stable system for the high-titer production of multiply attenuated lentiviral vectors.
- Mol Ther. 2000 Aug;2(2):170-6. Unique Identifier : AIDSLINE MED/20407630
- Klages N; Zufferey R; Trono D; Department of Genetics and Microbiology, University of Geneva,; Geneva, Switzerland.
- Lentiviral vectors open exciting perspectives for the genetic treatment of a wide array of inherited and acquired diseases, owing to their ability to govern the efficient delivery, integration, and long-term expression of transgenes into nondividing cells both in vitro and in vivo. The genomic complexity of HIV, where
- Fusion protein vectors to increase protein production and evaluate the immunogenicity of genetic vaccines.
- Mol Ther. 2000 Sep;2(3):288-97. Unique Identifier : AIDSLINE MED/20442636
- Wu L; Barry MA; Center for Cell and Gene Therapy, Baylor College of Medicine,; Houston, Texas, 77030, USA.
- Genetic immunization is a method for vaccination and laboratory antibody production where antigen-expressing plasmids are introduced into animals to elicit immune responses. Although genetic immunization works well for many antigens, problems can arise with protein sequences that (i) are toxic to host cells, (ii) are
- Development of an asthma vaccine: research into BCG.
- Drugs. 2000 Jun;59(6):1217-21. Unique Identifier : AIDSLINE MED/20338006
- Scanga CB; Le Gros G; Malaghan Institute of Medical Research, Wellington South, New; Zealand. cbscanga@malaghan.org.nz
- Asthma is an atopic disorder characterised by the activation and recruitment of eosinophils to the lung resulting in chronic swelling and inflammation of the airways. Allergic disorders such as atopic asthma and dermatitis have been increasingly prevalent in developed countries, and the inverse correlation between exp
- HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment.
- Drugs. 2000 Jun;59(6):1251-60. Unique Identifier : AIDSLINE MED/20338009
- Wulff EA; Wang AK; Simpson DM; Department of Neurology, The Mount Sinai Medical Center, New; York, New York 10029, USA.
- Peripheral neuropathy is the most frequent neurological complication associated with human immunodeficiency virus type 1 (HIV) infection and advanced acquired immunodeficiency syndrome (AIDS). There are at least 6 patterns of HIV-associated peripheral neuropathy , alth
- [New therapeutic application of thalidomide]
- Duodecim. 1996;112(7):623-7. Unique Identifier : AIDSLINE MED/20060214
- Saano V; Department of Pharmacology and Toxicology, University of Kuopio,; Finland.
- [Quantitative evaluation of sharing practices of materials at risk for infectious virus contamination by intravenous opiate users seeking treatment--application of the RAB(Risk for AIDS Behavior) self-administered questionnaire]
- Encephale. 2000 May-Jun;26(3):3-7. Unique Identifier : AIDSLINE MED/20407882
- Bertorelle V; Auriacombe M; Grabot D; Franques P; Martin C; Daulouede JP; Tignol J; Groupe d'Etude des Toxicomanies, Universite Victor Segalen; Bordeaux 2, France.
- The objective of this study was to quantify the occurrence of AIDS risk related sharing activities in i.v. opiate users seeking treatment using a self administered questionnaire. Subjects were recruited among first time consultants of an outpatient clinic and assessed using the Risk for AIDS Behavior questionnaire (RA
- Towards the selection of phosphorothioate aptamers optimizing in vitro selection steps with phosphorothioate nucleotides.
- Eur J Biochem. 2000 Aug;267(16):5032-40. Unique Identifier : AIDSLINE MED/20389524
- Andreola ML; Calmels C; Michel J; Toulme JJ; Litvak S; UMR 5097 CNRS-Universite Victor Segalen Bordeaux 2, Bordeaux,; France; Institut Federatif de Recherches 'Pathologies; Infectieuses' (IFR 66), Bordeaux, France.; marie-line.andreola@reger.u-bordeaux2.fr
- The high affinity of a given nucleic acid for a protein ligand can be used to isolate specific inhibitors of enzymes involved in pathological situations. The latter property is the basis of the SELEX (systematic evolution of ligands by exponential enrichment) technique. Recently, several potent nucleic acids inhibitor
- [Methodological issues and first results of a record linkage between AIDS and Cancer Registries in Italy]
- Epidemiol Prev. 2000 May-Jun;24(3):109-16. Unique Identifier : AIDSLINE MED/20421110
- Dal Maso L; Zanetti R; Orengo MA; Tagliabue G; Guzzinati S; Cavallieri F; Serventi L; Mangone L; Ferretti S; Milandri C; Pannelli F; Balzi D; Tonini G; Gafa L; Rezza G; Franceschi S; Servizio di epidemiologia, Centro di riferimento oncologico,; Aviano, PN. epidemiology@ets.it
- We report herein, the first results of a record linkage between the Italian AIDS Registry and 13 population-based Cancer Registries (about 8-million population in 1991). An anonymous linkage process was carried out on about 339,000 cancer notifications and 6,067 AIDS ones reported between 1982 and 1994. Out of 243 Kap
- [A advisory board for conscious access to therapies]
- Epidemiol Prev. 2000 May-Jun;24(3):136-7. Unique Identifier : AIDSLINE MED/20421116
- Nasta P
- Soluble tumor necrosis factor alpha receptors (sTNF-Rs) in HIV-1-infected intravenous drug users: change in circulating sTNF-R type II level and survival for AIDS patients.
- Eur J Epidemiol. 2000 Mar;16(3):209-16. Unique Identifier : AIDSLINE MED/20326749
- Ajello F; La Licata R; Lodato M; Vitale F; Bonura F; Valenti R; Bruno M; Romano N; Dipartimento di Igiene e Microbiologia G. D'Alessandro,; Universita degli Studi, Palermo, Italy.
- This study in intravenous drug users (IVDUs) investigated differences in serum soluble tumor necrosis factor types I and II (sTNFR-I and II) concentrations in HIV-1-infected IVDUs and controls. This study also investigated whether changes of sTNFRs concentration affect the risk of death among patients with AIDS. A cro
- Rifabutin-induced uveitis with inflammatory vitreous infiltrate.
- Eye. 2000 Jun;14 ( Pt 3a):344-6. Unique Identifier : AIDSLINE MED/20479097
- Khan MA; Singh J; Dhillon B; Princess Alexandra Eye Pavilion, Edinburgh, UK.
- PURPOSE: To describe an ocular complication of rifabutin therapy in the treatment of Mycobacterium avium complex (MAC) infection in the absence of HIV infection or AIDS. METHODS: Three patients on rifabutin therapy for MAC chest infection developed anterior uveitis with vitreous infiltrates. The clinical course and vi
- [Multicenter study of intrafamilial transmission of hepatitis C virus in human immunodeficiency virus infection]
- Gastroenterol Clin Biol. 2000 Jun-Jul;24(6-7):611-7. Unique Identifier : AIDSLINE MED/20419922
- Huet C; Dabis F; Saillour F; Trimoulet P; Morlat P; Rispal P; Dupon M; De La Taille C; Partisani M; Bertrand M; Ragnaud JM; Couzigou P; Unite INSERM 330, Universite Victor Segalen Bordeaux 2,; Bordeaux.
- OBJECTIVE: Intrafamilial transmission of hepatitis C virus in human immunodeficiency virus and hepatitis C virus co-infections is not well documented. This cross-sectional study evaluated the transmission of hepatitis C virus in the sexual partners of hepatitis C virus and human immunodeficiency virus co-infected pati
- [Efficacity of treatment with lamivudine in two patients with severe reactivation of hepatitis B after withdrawal of chemotherapy]
- Gastroenterol Clin Biol. 2000 Jun-Jul;24(6-7):671-4. Unique Identifier : AIDSLINE MED/20419932
- Seksik P; Nahon S; Lesgourgues B; Cadranel JF; Mariaud De Serre N; Lenoble M; Lahmeck P; Charoud A; Delas N; Service d'Hepato-gastroenterologie et de Medecine Interne,; Centre Hospitalier Intercommunal Le Raincy-Montfermeil,; Montfermeil.
- Reactivation of chronic infection is a serious complication during and especially after the withdrawal of cancer chemotherapy in hepatitis B virus carriers. Mortality is high, ranging from 4 to 20%. We report two cases of severe reactivation, after withdrawal of chemotherapy for chronic lymphocytic leukemia in one cas
- The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses.
- Free Radic Biol Med. 2000 May 1;28(9):1328-37. Unique Identifier : AIDSLINE MED/20384622
- Rincon M; Flavell RA; Davis RA; Immunobiology Program, Department of Medicine, University of; Vermont, Burlington, VT 05405, USA. mrincon@zoo.uvm.edu
- The mitogen-activated protein (MAP) kinase family members, which include the extracellular response kinases (ERK), p38, and c-Jun amino terminal kinases (JNK), play a role in mediating signals triggered by cytokines, growth factors, and environmental stress. JNK and p38 MAP kinases have been involved in inflammatory p
- Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea.
- Hepatology. 2000 Oct;32(4 Pt 1):803-6. Unique Identifier : AIDSLINE MED/20459032
- Song BC; Suh DJ; Lee HC; Chung YH; Lee YS; Department of Internal Medicine, University of Ulsan College of; Medicine, Asan Medical Center, Seoul, Korea.
- It has been suggested that hepatitis B e antigen (HBeAg) seroconversion after lamivudine therapy is durable in Caucasians with chronic hepatitis B (CHB). However, little is known whether it is also durable in endemic areas of hepatitis B virus (HBV) infection. We evaluated the posttreatment durability of lamivudine-in
- Long-term therapy of chronic hepatitis B with lamivudine [see comments]
- Hepatology. 2000 Oct;32(4 Pt 1):828-34. Unique Identifier : AIDSLINE MED/20459036
- Lau DT; Khokhar MF; Doo E; Ghany MG; Herion D; Park Y; Kleiner DE; Schmid P; Condreay LD; Gauthier J; Kuhns MC; Liang TJ; Hoofnagle JH; Liver Diseases Section, Digestive Diseases Branch, National; Institute of Diabetes and Digestive and Kidney Diseases, National; Institutes of Health, Bethesda, MD, USA.
- Lamivudine therapy induces improvements in chronic hepatitis B in a high proportion of patients, but prolonged therapy is limited by the development of viral resistance. We analyzed clinical responses and virologic resistance in 27 patients treated co
- Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B.
- Hepatology. 2000 Oct;32(4 Pt 1):847-51. Unique Identifier : AIDSLINE MED/20459039
- Hadziyannis SJ; Papatheodoridis GV; Dimou E; Laras A; Papaioannou C; Academic Department of Medicine, Hippokration General Hospital,; Athens, Greece. hadziyannis@ath.forthnet.gr
- We evaluated the safety and efficacy of long-term lamivudine monotherapy in a group of 25 patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. Lamivudine was administered in a daily dose of 150 mg for a mean of 26 +/- 7 months and
- The impact of drug resistance on the effectiveness of chemotherapy for chronic hepatitis B [editorial; comment]
- Hepatology. 2000 Oct;32(4 Pt 1):866-7. Unique Identifier : AIDSLINE MED/20459042
- Richman DD
- CD138-positive and Kaposi's sarcoma-associated herpesvirus (KSHV)-negative B-cell lymphoma with serosal spreading of the body cavity and lymphadenopathy: an autopsy case.
- Hum Pathol. 2000 Sep;31(9):1171-5. Unique Identifier : AIDSLINE MED/20466516
- Kuwabara H; Nagai M; Shibanushi T; Ohmori M; Kawakami K; Asakura H; Department of Pathology, Kagawa Medical University, Japan.
- CD138-positive and Kaposi s sarcoma-associated herpes virus (KSHV)-negative B cell lymphoma with serosal spreading of the body cavity and lymphadenopathy is presented. Our lymphoma cells showed pleomorphic morphology and a clonal immunoglobulin gene rearrangement. Immunophenotypically, they lacked B- and T-cell-associ
- Interleukin-8 fails to induce human immunodeficiency virus-1 expression in chronically infected promonocytic U1 cells but differentially modulates induction by proinflammatory cytokines.
- Unique Identifier : AIDSLINE MED/20467765
- Tiemessen CT; Kilroe B; Martin DJ; AIDS Virus Research Unit, National Institute for Virology and; Department of Virology, University of the Witwatersrand,; Johannesburg, South Africa.
- This study addresses the role of interleukin (IL)-8, a CXC-chemokine, the level of which is reported to be raised in the peripheral circulation of human immunodeficiency virus-1 (HIV-1)-infected individuals, during the induction of HIV-1 expression from latency and during cytokine-mediated HIV-1 up-regulation. IL-8 at
- Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55.
- Immunology. 2000 Sep;101(1):154-60. Unique Identifier : AIDSLINE MED/20467767
- Neidleman JA; Vajdy M; Ugozzoli M; Ott G; O'Hagan D; Chiron Corporation, Emeryville, CA, USA.
- There is an urgent need for prophylactic and therapeutic vaccines against human immunodeficiency virus (HIV). Mucosal immunization strategies have great potential to elicit both mucosal and systemic cellular immunity required to protect against HIV-induced acquired immune deficiency syndrome (AIDS). However, mucosal i
- Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines.
- Immunology. 2000 Sep;101(1):46-52. Unique Identifier : AIDSLINE MED/20467752
- Lipford GB; Bendigs S; Heeg K; Wagner H; Institute of Medical Microbiology, Immunology and Hygiene,; Technical University of Munich, Munich, Germany.
- Pathogen-derived pattern recognition ligands like lipopolysaccharide (LPS) and bacterial cytidine-guanosine (CpG)-DNA not only activate dendritic cells and macrophages but are also mitogenic for B cells. Less clear are the claimed effects of CpG-DNA on T cells, which range from direct activation, costimulation, or ind
- Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes.
- Immunology. 2000 Sep;101(1):76-82. Unique Identifier : AIDSLINE MED/20467756
- Nakagawa Y; Takeshita T; Berzofsky JA; Takahashi H; Department of Microbiology and Immunology, Nippon Medical School,; Tokyo, Japan.
- An immunodominant epitope of human immunodeficiency virus-1 (HIV-1) gp160 recognized by Dd class I major histocompatibility complex (MHC) molecule-restricted, CD8+ cytotoxic T lymphocytes (CTL) was originally identified as a peptide composed of 15 amino acids (P18IIIB: RIQRGPGRAFVTIGK). However, further study has indi
- Immunoperoxidase technique for detecting spirochetes in tissue sections: comparison with other methods.
- Int J Dermatol. 2000 Aug;39(8):609-13. Unique Identifier : AIDSLINE MED/20428633
- Phelps RG; Knispel J; Tu ES; Cernainu G; Saruk M; Departments of Dermatology and Pathology, The Mount Sinai School; of Medicine, New York, New York, USA.
- BACKGROUND: With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essent
- Perianal Crohn's disease.
- Int J Dermatol. 2000 Aug;39(8):616-8. Unique Identifier : AIDSLINE MED/20428635
- Morales MS; Marini M; Caminero M; Caglio P; Department of Dermatology, Ramos Mejia and British Hospitals,; Buenos Aires, Argentina.
- A 13-year-old girl with a history of 4 months of perianal skin lesions is described. Physical examination revealed three 0.5 I 1-cm red, swollen, fleshy, skin tags extending from the perianal area to the perineum (Fig. 1). The patient reported intermittent fever, diarrhea, and abdominal pain, and her body weight was b
- Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats.
- Int J Vitam Nutr Res. 2000 Jul;70(4):167-71. Unique Identifier : AIDSLINE MED/20444967
- Funada U; Wada M; Kawata T; Mori K; Tamai H; Kawanishi T; Kunou A; Tanaka N; Tadokoro T; Maekawa A; Faculty of Applied Bioscience, Tokyo University of Agriculture,; Japan.
- To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ rat
- Development of simultaneous resistance to fluconazole in Candida albicans and Candida dubliniensis in a patient with AIDS.
- J Antimicrob Chemother. 2000 Aug;46(2):291-5. Unique Identifier : AIDSLINE MED/20391947
- Ruhnke M; Schmidt-Westhausen A; Morschhauser J; Universitatsklinikum Charite Campus Virchow Klinikum, Abteilung; fur Innere Medizin, Humboldt Universitat zu Berlin, D-13353; Berlin, Germany. markus.ruhnke@charite.de
- In this report, we describe a patient with recurrent episodes of oral candidosis who finally suffered from fluconazole-refractory oral and oesophageal candidosis. The patient was monitored for 4 years until his death from AIDS. During the observation period, persistent colonization with both Candida albicans and Candi
- Azole cross-resistance to ketoconazole, fluconazole, itraconazole and voriconazole in clinical Candida albicans isolates from HIV-infected children with oropharyngeal candidosis [letter]
- J Antimicrob Chemother. 2000 Aug;46(2):338-40. Unique Identifier : AIDSLINE MED/20391964
- Muller FM; Weig M; Peter J; Walsh TJ
- Mucocutaneous leishmaniasis associated with HIV infection treated successfully with liposomal amphotericin B (AmBisome) [letter]
- J Antimicrob Chemother. 2000 Aug;46(2):341-2. Unique Identifier : AIDSLINE MED/20391965
- Amato VS; Nicodemo AC; Amato JG; Boulos M; Neto VA
- Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates.
- J Biol Chem. 2000 Sep 8;275(36):28033-8. Unique Identifier : AIDSLINE MED/20428718
- Osheroff WP; Beard WA; Yin S; Wilson SH; Kunkel TA; Laboratory of Molecular Genetics and Laboratory of Structural; Biology, NIEHS, National Institutes of Health, Research Triangle; Park, North Carolina 27709, USA.
- The structures of open and closed conformations of DNA polymerase beta (pol beta) suggests that the rate of single-nucleotide deletions during synthesis may be modulated by interactions in the DNA minor groove that align the templating base with the incoming dNTP. To test this hypothesis, we measured the single-base d
- Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.
- J Biol Chem. 2000 Sep 8;275(36):28100-9. Unique Identifier : AIDSLINE MED/20428726
- Mavaddat N; Mason DW; Atkinson PD; Evans EJ; Gilbert RJ; Stuart DI; Fennelly JA; Barclay AN; Davis SJ; Brown MH; Sir William Dunn School of Pathology, The University of Oxford,; Oxford OX1 3RE, United Kingdom.
- Signaling lymphocytic activating molecule ((SLAM) CDw150) is a glycoprotein that belongs to the CD2 subset of the immunoglobulin superfamily and is expressed on the surface of activated T- and B-cells. It has been proposed that SLAM is homophilic and required for bidirectional signaling during T- and B-cell activation
- Flavopiridol inhibits P-TEFb and blocks HIV-1 replication.
- J Biol Chem. 2000 Sep 15;275(37):28345-8. Unique Identifier : AIDSLINE MED/20435781
- Chao SH; Fujinaga K; Marion JE; Taube R; Sausville EA; Senderowicz AM; Peterlin BM; Price DH; Molecular Biology Program and the Department of Biochemistry,; University of Iowa, Iowa City, Iowa 52242, USA.
- Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor that is in clinical trials as a cancer treatment because of its antiproliferative properties. We found that the flavonoid potently inhibited transcription by RNA polymerase II in vitro by blocking the transition into productive elongation, a
- Comparison of a point mutation assay with a line probe assay for the detection of the major mutations in the HIV-1 reverse transcriptase gene associated with reduced susceptibility to nucleoside analogues.
- J Virol Methods. 2000 Aug;88(2):117-24. Unique Identifier : AIDSLINE MED/20418137
- Clarke JR; Kaye S; Babiker AG; Hooker MH; Tedder R; Weber JN; Department of Genitourinary Medicine and Communicable Diseases,; Jefferiss Trust Laboratories, Imperial College School of; Medicine, St Mary's Hospital, Paddington, London W 2 1PG, UK.; j.r.clarke@ic.ac.uk
- This study compares the performance of a line probe assay (LiPA) for the detection of the major mutations associated with reduced sensitivity to nucleoside analogues with a well characterised point mutation assay (PMA). Plasma samples obtained from patients in a trial of four reverse transcriptase inhibitors (MRC Quat
- A rapid plate assay for the screening of inhibitors against herpesvirus DNA polymerases and processivity factors.
- J Virol Methods. 2000 Aug;88(2):219-25. Unique Identifier : AIDSLINE MED/20418147
- Lin K; Ricciardi RP; Department of Biochemistry and Biophysics, School of Medicine,; University of Pennsylvania, Philadelphia, PA 19104, USA.
- Kaposi s sarcoma-associated herpesvirus (KSHV) is a newly identified human pathogen with tumorigenic potential. The DNA polymerase (Pol-8) and processivity factor (PF-8) of KSHV were cloned recently. It was shown that PF-8 forms specifically a complex with Pol-8 in vitro and allows it to synthesize fully-extended DNA.
- Colorectal cancer screening in older men and women: qualitative research findings and implications for intervention.
- J Community Health. 2000 Jun;25(3):263-78. Unique Identifier : AIDSLINE MED/20324670
- Beeker C; Kraft JM; Southwell BG; Jorgensen CM; Communication and Behavioral Sciences Branch, Division of Cancer; Prevention and Control, National Center for Chronic Disease; Prevention and Health Promotion, Centers for Disease Control and; Prevention, Atlanta, GA, USA.
- As part of the formative research for developing interventions to increase colorectal cancer screening in men and women aged 50 and older, 14 focus groups were conducted to identify (1) knowledge, attitudes, and beliefs about colorectal cancer and colorectal cancer screening, (2) barriers to screening, and (3) strateg
- Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing.
- J Dent Res. 2000 Aug;79(8):1548-55. Unique Identifier : AIDSLINE MED/20476124
- Takeichi O; Haber J; Kawai T; Smith DJ; Moro I; Taubman MA; Department of Endodontics, Nihon University, School of Dentistry,; Tokyo, Japan.
- Periodontal disease is an infection in which destruction occurs at sites remote from the infection, resulting in pathological pocketing. Intervening between the infection and the destruction is a dense mononuclear inflammatory infiltrate. It has been suggested that this infiltrate might have characteristics and the de
- Drug-resistant viral hepatitis.
- J Infect. 2000 Jul;41(1):1-4. Unique Identifier : AIDSLINE MED/20402423
- Wright M; Main J; Thomas HC; Department of Medicine, Imperial College School of Medicine at St; Mary's Hospital, London, W2 1NY, U.K.
- Second episode of tuberculosis in an HIV-infected child: relapse or reinfection?
- J Infect. 2000 Jul;41(1):100-3. Unique Identifier : AIDSLINE MED/20486740
- Schaaf HS; Gie RP; van Rie A; Seifart HI; van Helden PD; Cotton MF; Department of Paediatrics and Child Health, University of; Stellenbosch, Tygerberg, South Africa.
- We report a case of an HIV-infected child with a second episode of tuberculosis 22 months after completing antituberculosis treatment. DNA fingerprinting of organisms from both episodes showed an identical strain of Mycobacterium tuberculosis. We believe this to be the first case of confirmed relapsed tuberculosis in
- A case of costochondral abscess due to Corynebacterium minutissimum in an HIV-infected patient.
- J Infect. 2000 Jul;41(1):103-5. Unique Identifier : AIDSLINE MED/20486741
- Bandera A; Gori A; Rossi MC; Degli Esposti A; Ferrario G; Marchetti G; Tocalli L; Franzetti F; Institute of Infectious Diseases and Tropical Medicine, "Luigi; Sacco" Hospital, University of Milan, Italy.
- Corynebacterium minutissimum, known as the causative agent of erythrasma, has recently been reported as a clinically significant pathogen in the immunocompromised host. We report for the first time the possible involvement of a multidrug-resistant C. minutissimum strain in a costochondral abscess occurring in an HIV-i
- Favourable outcome of haemolytic uraemic syndrome in an HIV-infected patient treated only with prednisone [letter]
- J Infect. 2000 Jul;41(1):108-9. Unique Identifier : AIDSLINE MED/20402435
- Bottieau E; Colebunders R; Bosmans JL
- A rare infection caused by Chryseomonas luteola [letter]
- J Infect. 2000 Jul;41(1):109-10. Unique Identifier : AIDSLINE MED/20402436
- Ghosh SK
- Comparisons of hepatitis B and C and HIV prevalence rates [letter]</