2000
- Immunopathology of schistosomiasis mansoni in mice and men [letter]
- Immunol Today. 2000 Sep;21(9):465-6. Unique Identifier : AIDSLINE MED/20411113
- Cheever AW; Hoffmann KF; Wynn TA
- Directions for biomedical research in alcohol and HIV: where are we now and where can we go?
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1197-207. Unique Identifier : AIDSLINE MED/20414615
- Isaki L; Kresina TF; Division of Basic Research, National Institute on Alcohol Abuse; and Alcoholism, National Institutes of Health, Bethesda, Maryland; 20892, USA.
- Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1209-13. Unique Identifier : AIDSLINE MED/20414616
- Bally F; Martinez R; Peters S; Sudre P; Telenti A; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.
- Amino acid substitutions at HIV-1 Gag p7/p1 and p1/p6 cleavage sites may be selected under antiretroviral pressure or represent natural polymorphisms. Whether changes are associated with specific protease (PR) mutation patterns and different clinical evolution has not been investigated. p7/p1 and p1/p6 cleavage site s
- Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1215-21. Unique Identifier : AIDSLINE MED/20414617
- Look MP; Altfeld M; Kreuzer KA; Riezler R; Stabler SP; Allen RH; Sauerbruch T; Rockstroh JK; Department of General Internal Medicine, University of Bonn,; Germany. Look@Uni-Bonn.de
- The chronic immune activation state in HIV disease leads to increased activity of the rate-limiting tryptophan-kynurenine pathway enzyme indoleamine 2,3-dioxygenase (2,3-IDO), thereby increasing the formation of neurotoxic tryptophan metabolites such as kynurenine and quinolinic acid. We investigated whether highly ac
- Genetic analysis of viral variants selected in transmission of human immunodeficiency viruses to newborns.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1223-33. Unique Identifier : AIDSLINE +
- Kliks S; Contag CH; Corliss H; Learn G; Rodrigo A; Wara D; Mullins JI; Levy JA; Cancer Research Institute and Department of Pediatrics, School of; Medicine, University of California, San Francisco 94143, USA.
- Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral
- Natural variation in the amino acid sequence around the HIV type 1 glycoprotein 160 cleavage site and its effect on cleavability, subunit association, and membrane fusion.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1235-45. Unique Identifier : AIDSLINE MED/20414619
- Adams O; Schaal H; Scheid A; Institut fur Medizinische Mikrobiologie und Virologie,; Heinrich-Heine-Universitat, Dusseldorf, Germany.; adamso@uni-duesseldorf.de
- To assess the natural variation of the structure of the cleavage site as well as the N-terminal region of gp41 for the cytopathogenicity of HIV-1, syncytium-inducing (SI) and non-syncytium-inducing (NSI) virus isolates were obtained from HIV-1-infected patients. In addition, the coreceptor usage of the isolates was de
- Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1247-57. Unique Identifier : AIDSLINE MED/20414620
- Hofmann-Lehmann R; Swenerton RK; Liska V; Leutenegger CM; Lutz H; McClure HM; Ruprecht RM; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
- Plasma viral RNA load is a key parameter in disease progression of lentiviral infections. To measure simian immunodeficiency virus (SIV) RNA loads, we have established a quantitative one-tube assay based on TaqMan chemistry. This real-time reverse transcriptase-polymerase chain reaction (RT-PCR) has advantages compare
- Generation of monoclonal antibodies specifically directed against the proximal zinc finger of HIV type 1 NCp7.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1259-67. Unique Identifier : AIDSLINE MED/20414621
- De Rocquigny H; Caneparo A; Dong CZ; Delaunay T; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale,; INSERM U266-CNRS UMR 8600, UFR des Sciences Pharmaceutiques et; Biologiques, Paris, France.
- The HIV-1 NCp7 contains two spatially close zinc fingers, required for the production of infectious particles. To investigate in more detail the function of the zinc finger domain, monoclonal antibodies were generated with a cyclic analog of the NCp7 proximal zinc finger. This analog was shown to bind zinc ions and to
- Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1269-80. Unique Identifier : AIDSLINE MED/20414622
- Isaguliants MG; Gudima SO; Ivanova OV; Levi M; Hinkula J; Garaev MM; Kochetkov SN; Wahren B; D. I. Ivanovsky Institute of Virology, Moscow, Russia.; maria.isaguliants@smi.ki.se
- Genetic immunization may be one way to prime individuals for a subsequent broad anti-HIV-1 immune response. Reverse transcriptase of HIV-1 (RT) presents a selective target for attempts to arrest replication of HIV-1. Rabbits immunized with a plasmid carrying the gene for reverse transcriptase HIV-1 (RT DNA) developed
- Monoclonal antibodies to native HIV type 1 reverse transcriptase and their interaction with enzymes from different subtypes.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1281-94. Unique Identifier : AIDSLINE MED/20414623
- Rytting AS; Akerblom L; Albert J; Unge T; Bjorling E; Al-Khalili L; Gronowitz JS; Kallander CF; Unit of Medical Genetics, Department of Genetics and Pathology,; Uppsala University, BMC, Sweden.
- Recombinant reverse transcriptase (RT) from HIV-1 subtype B was used to produce mouse anti-RT monoclonal antibodies (MAbs). Immunization was done by mixing RT with the ISCOM matrix-forming adjuvant saponin (Quil A). Two different assays, both based on the interaction of native RT and antibodies, were used to monitor t
- Simian-human immunodeficiency virus-associated nephropathy in macaques.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1295-306. Unique Identifier : AIDSLINE MED/20414624
- Stephens EB; Tian C; Dalton SB; Gattone VH 2nd; Department of Microbiology, Molecular Genetics, and Immunology,; University of Kansas Medical Center, Kansas City 66160, USA.; estephen@kumc.edu
- A number of chimeric simian-human immunodeficiency virus (SHIV) viruses containing tat, rev, vpu, and env from HIV-1 (strain HXBc2) in a genetic background of simian immunodeficiency virus (SIV(mac)239) have been derived from the parental nonpathogenic SHIV-4 virus. In this article we examine the renal pathology assoc
- Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1307-12. Unique Identifier : AIDSLINE GENBANK/AJ246945
- Parreira R; Esteves A; Santos C; Piedade J; Venenno T; Canas-Ferreira WF; Unidade de Virologia/Unidade de Parasitologia e Microbiologia; Medicas, Instituto de Higiene e Medicina Tropical, Universidade; Nova de Lisboa, Portugal. Ricardo@ihmt.unl.pt
- The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositi
- Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. The European Network on the Study of In Utero Transmission of HIV-1.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1313-8. Unique Identifier : AIDSLINE GENBANK/AF268354
- Tscherning-Casper C; Dolcini G; Mauclere P; Fenyo EM; Barre-Sinoussi F; Albert J; Menu E; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden. charlotte.tscherning@mtc.ki.se
- Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger co
- Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.
- AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1319-24. Unique Identifier : AIDSLINE GENBANK/AF252111
- Fonjungo PN; Mpoudi EN; Torimiro JN; Alemnji GA; Eno LT; Nkengasong JN; Gao F; Rayfield M; Folks TM; Pieniazek D; Lal RB; HIV/AIDS and Retrovirology Branch, Division of AIDS, STD and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H
- Guidelines for the diagnosis and management of HIV disease.
- J Am Acad Nurse Pract. 1999 Dec;11(12):519-26. Unique Identifier : AIDSLINE MED/20456023
- Whyte J 4th; Dawson SB; Beaufort Naval Hospital, SC, USA.
- HIV/AIDS, WHO Western Pacific Region, revised 1999 estimates.
- Wkly Epidemiol Rec. 2000 Aug 18;75(33):266-8. Unique Identifier : AIDSLINE MED/20430648
- Adenoids provide a microenvironment for the generation of CD4(+), CD45RO(+), L-selectin(-), CXCR4(+), CCR5(+) T lymphocytes, a lymphocyte phenotype found in the middle ear effusion.
- Int Immunol. 2000 Sep;12(9):1235-43. Unique Identifier : AIDSLINE MED/20425414
- Mattila PS; Nykanen A; Eloranta M; Tarkkanen J; Department of Otorhinolaryngology, Helsinki University Central; Hospital, Haartmaninkatu 4 E, 00290 Helsinki, Finland.
- Adenoidectomy in children with otitis media with effusion reduces inflammation in the middle ear by an unknown mechanism. Potentially, the adenoids of these children may serve as a site for the differentiation of lymphocytes, which after entering blood circulation eventually extravasate in the middle ear mucosa and th
- Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications.
- Int Immunol. 2000 Sep;12(9):1293-302. Unique Identifier : AIDSLINE MED/20425420
- Dela Cruz CS; Tan R; Rowland-Jones SL; Barber BH; Department of Immunology and Institute of Medical Science,; University of Toronto, Medical Sciences Building, 1 King's; College Circle, Ontario M5S 1A8, Canada.
- Vigorous HIV-1-specific CD8(+) cytotoxic T lymphocyte (CTL) responses play an important role in the control of HIV-1 replication and the induction of a strong, broadly cross-reactive CTL response remains an important goal of HIV vaccine development. It is known that the display of high levels of class I MHC-viral pept
- Influence of nucleotide polymorphisms in the CCR2 gene and the CCR5 promoter on the expression of cell surface CCR5 and CXCR4.
- Int Immunol. 2000 Sep;12(9):1311-8. Unique Identifier : AIDSLINE MED/20425422
- Shieh B; Liau YE; Hsieh PS; Yan YP; Wang ST; Li C; Department of Biochemistry, Chung Shan Medical and Dental; College, No. 110, Section 1, Chien Kuo North Road, Taichung 402,; Taiwan, ROC.
- Polymorphisms in the CCR2 gene (CCR2-64I) and the CCR5 promoter (pCCR5-59029G) have been correlated with slower HIV-1 disease progression. How these polymorphisms influence the rate of AIDS progression has remained unclear. We have therefore investigated whether these nucleotide polymorphisms will reduce the expressio
- Affinity of thymic self-peptides for the TCR determines the selection of CD8(+) T lymphocytes in the thymus.
- Int Immunol. 2000 Sep;12(9):1353-63. Unique Identifier : AIDSLINE MED/20425427
- Ober BT; Hu Q; Opferman JT; Hagevik S; Chiu N; Wang CR; Ashton-Rickardt PG; Department of Pathology, University of Chicago, 924 E. 57th; Street, R414, IL 60637, USA.
- Experiments with synthetic antigen peptides have suggested that a critical parameter that determines the developmental fate of an immature thymocyte is the affinity of interaction between TCR and self-peptide/MHC expressed on thymic stromal cells. To test the physiological relevance of this model for thymocyte develop
- Monocyte inflammatory protein-1 alpha facilitates priming of CD8(+) T cell responses to exogenous viral antigen.
- Int Immunol. 2000 Sep;12(9):1365-70. Unique Identifier : AIDSLINE MED/20425428
- Flesch IE; Stober D; Schirmbeck R; Reimann J; Department of Medical Microbiology and Immunology, University of; Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
- Dendritic cells (DC) derived from bone marrow precursors of BALB/c or C57BL/6 mice in low-serum cultures supplemented with granulocyte macrophage colony stimulating factor and Flt(3) ligand were pulsed in vitro with hepatitis B surface antigen (HBsAg) particles. DC processed exogenous HBsAg and presented its MHC class
- Mandibular fracture after wire suspension reduction technique in patient with HIV [letter]
- Br J Oral Maxillofac Surg. 2000 Aug;38(4):397. Unique Identifier : AIDSLINE MED/20380803
- Rodriguez-Recio O; Junquera LM; Calvo N
- Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: roles of the beta 8-alpha E loop in fidelity, processivity, and substrate interactions.
- Biochemistry. 2000 Sep 5;39(35):10684-94. Unique Identifier : AIDSLINE MED/20435243
- Weiss KK; Isaacs SJ; Tran NH; Adman ET; Kim B; Department of Microbiology and Immunology, University of; Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester,; New York 14642, USA.
- Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a putative source of the genomic hypermutation that promotes rapid evolution of HIV-1. To understand the molecular strategies that create a highly mutagenic DNA polymerase active site in HIV-1 RT, we investigated the roles of four residues in th
- Recognition properties of V3-specific antibodies to V3 loop peptides derived from HIV-1 gp120 presented in multiple conformations.
- Biochemistry. 2000 Sep 5;39(35):10866-76. Unique Identifier : AIDSLINE MED/20435264
- Huisman JG; Carotenuto A; Labrijn AF; Papavoine CH; Laman JD; Schellekens MM; Koppelman MH; Hilbers CW; CLB, Sanquin Blood Supply Foundation, Laboratory for Clinical and; Experimental Immunology, Department of Pathophysiology of Plasma; Proteins, Amsterdam, The Netherlands.
- To identify structural constraints and amino acid sequences important for antibody recognition of the third variable domain (V3) of HIV-1 gp120, we have studied the solution conformation of three 35-mer circular V3 loop peptides derived from HIV-1 strains which differ in syncytium- (SI) and non-syncytium-inducing (NSI
- Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C.
- Eur Cytokine Netw. 2000 Jun;11(2):177-84. Unique Identifier : AIDSLINE MED/20363558
- Balian A; Naveau S; Zou W; Durand-Gasselin I; Bouchet L; Foussat A; Galanaud P; Chaput JC; Emilie D; Hopital Antoine-Beclere, Insitut Paris-Sud sur les Cytokines,; 92140 Clamart, France. axel.balian@abc.ap-hop-paris.fr
- It would be of great value to be able to predict, before the initiation of treatment, which patients with hepatitis C virus-induced chronic hepatitis will be cured by interferon-alpha (IFN-alpha). Competitive RT-PCR was used to evaluate spontaneous expression of the perforin gene, a marker of cytotoxic cell activation
- Hyperglycemia associated with protease inhibitors in an urban HIV-infected minority patient population.
- Ann Pharmacother. 2000 May;34(5):580-4. Unique Identifier : AIDSLINE MED/20308923
- Dever LL; Oruwari PA; Figueroa WE; O'Donovan CA; Eng RH; Infectious Diseases Clinic, Veterans Affairs New Jersey Health; Care System, East Orange 07018, USA.; dever.lisa@east-orange.va.gov
- BACKGROUND: Hyperglycemia and new-onset diabetes mellitus have been reported to occur in HIV-infected patients treated with protease inhibitors . OBJECTIVE: To determine the effect of protease inhibitor therapy on serum glucose in a predominantly minority patient pop
- Treatment of listeriosis.
- Ann Pharmacother. 2000 May;34(5):656-61. Unique Identifier : AIDSLINE MED/20308935
- Temple ME; Nahata MC; Infectious Disease and Pediatric Pharmacotherapy, College of; Pharmacy, The Ohio State University, Columbus 43210, USA.
- OBJECTIVE: To review the most currently accepted treatment options for the treatment of listeriosis. DATA SOURCES: Clinical literature was accessed through MEDLINE (1966-October 1999). Key search terms included Listeria monocytogenes, food-borne illness, penicillins, fluoroquinolones, cephalosporins, and vancomycin. D
- [Management and care of severely ill patients in ambulatory care nursing--results of an evaluation study]
- Gesundheitswesen. 2000 May;62(5):264-9. Unique Identifier : AIDSLINE MED/20352338
- Schaeffer D; Ewers M; Institut fur Pflegewissenschaft, Universitat Bielefeld.; ipw@uni-bielefeld.de
- The last few years have seen numerous attempts to expand outpatient nursing and adapt it to the changing health problems of the population. Even so, outpatient nursing care for severely ill patients and those with complex nursing needs still has its shortcomings. Today, it may well be the case that these patients, too
- Reducing the risk of infection from plasma products: specific preventative strategies.
- Blood Rev. 2000 Jun;14(2):94-110. Unique Identifier : AIDSLINE MED/20456244
- Burnouf T; Radosevich M; Human Plasma Product Services (HPPS), Lille, France.; tburnou@attglobal.net
- Collection and testing procedures of blood and plasma that are designed to exclude donations contaminated by viruses provide a solid foundation for the safety of all blood products. Plasma units may be collected from a selected donor population, contributing to the exclusion of individuals at risk of carrying infectio
- Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.
- Stem Cells. 2000;18(4):230-44. Unique Identifier : AIDSLINE MED/20382679
- Sewell AK; Price DA; Oxenius A; Kelleher AD; Phillips RE; The Nuffield Department of Medicine, John Radcliffe Hospital,; Oxford, UK. asewell@gwmail.jr2.ox.ac.uk
- Effective preventive and therapeutic intervention in individuals exposed to or infected with human immunodeficiency virus (HIV) depends, in part, on a clear understanding of the interactions between the virus and those elements of the host immune response which control viral replication. Recent advances have provided
- Health-related quality of life among people with HIV disease: results from the Multicenter AIDS Cohort Study.
- Qual Life Res. 2000 Feb;9(1):55-63. Unique Identifier : AIDSLINE MED/20436501
- Bing EG; Hays RD; Jacobson LP; Chen B; Gange SJ; Kass NE; Chmiel JS; Zucconi SL; Department of Psychiatry, Charles R. Drew University of Medicine; & Science, Los Angeles, CA 90059, USA.
- To examine the effect of HIV status, symptomatology and CD4+ lymphocyte level on health-related quality of life, the Medical Outcomes Study Short-Form Health Survey (SF-36) was administered to 2,295 gay men enrolled in the Multicenter AIDS Cohort Study (MACS) in 1994. Distinct physical and mental health factors of the
- [Lymphomas in children infected with HIV-1]
- Arch Pediatr. 2000 Jul;7(7):738-44. Unique Identifier : AIDSLINE MED/20397084
- Gandemer V; Verkarre V; Quartier P; Brousse N; Blanche S; Unite d'immunologie-hematologie pediatrique, hopital; Necker-Enfants-malades, Paris, France.
- PURPOSE: To describe the features of lymphoma in human immunodeficiency virus (HIV)-infected children, their treatments and the outcome of patients. RESULTS: We analyzed seven HIV-infected children (four by mother-to-child transmission and three by transfusion) (25 months to 18.5 years old) with lymphoma (one Hodgkin
- Gene therapy and the two faces of HIV [editorial]
- Gene Ther. 2000 Aug;7(16):1351-2. Unique Identifier : AIDSLINE MED/20434539
- Wong-Staal F; Buchschacher GL Jr
- Antisense RNA sequences targeting the 5' leader packaging signal region of human immunodeficiency virus type-1 inhibits viral replication at post-transcriptional stages of the life cycle.
- Gene Ther. 2000 Aug;7(16):1362-8. Unique Identifier : AIDSLINE MED/20434541
- Chadwick DR; Lever AM; Department of Medicine, University of Cambridge, Addenbrooke's; Hospital, UK.
- Antisense RNA has proven a potent inhibitor of gene expression and has the potential to inhibit retroviral replication at a number of stages in the virus life cycle by targeting both viral and cellular RNA sequences. Antisense RNA complementary to three target regions in the 5 leader/LTR of human immunodeficiency vir
- Improved titers of HIV-based lentiviral vectors using the SRV-1 constitutive transport element.
- Gene Ther. 2000 Aug;7(16):1421-4. Unique Identifier : AIDSLINE MED/20434549
- Mautino MR; Keiser N; Morgan RA; Clinical Gene Therapy Branch, National Human Genome Research; Institute, National Institutes of Health, Bethesda, MD; 20892-1851, USA.
- The development of lentiviral vectors that use Rev-independent mechanisms of nuclear export for their genomic RNA could facilitate the construction of novel anti-HIV vectors. We have improved the titers of Rev-independent lentiviral vectors having the SRV-1 CTE by mutating the major splice donor and acceptor sites pre
- Eradication of established tumors by CD8+ T cell adoptive immunotherapy.
- Immunity. 2000 Aug;13(2):265-76. Unique Identifier : AIDSLINE MED/20434848
- Hanson HL; Donermeyer DL; Ikeda H; White JM; Shankaran V; Old LJ; Shiku H; Schreiber RD; Allen PM; Department of Pathology and Center for Immunology, Washington; University School of Medicine, St. Louis, Missouri 63110, USA.
- We generated the DUC18 T cell receptor transgenic mouse expressing an H-2Kd -restricted transgenic T cell receptor specific for the syngeneic CMS5 fibrosarcoma rejection antigen mutated ERK2(136-144). DUC18 mice were capable of specifically eliminating lethal CMS5 tumor challenges, and transfer of DUC18 splenocytes to
- [Cytokine and cytokine receptor deficiencies causing defects in T cell/Th 1 cell differentiation and function]
- Nihon Rinsho Meneki Gakkai Kaishi. 2000 Jun;23(3):173-80. Unique Identifier : AIDSLINE MED/20373729
- Hara T; Sasaki Y; Nomura A; Takada H; Department of Pediatrics, Graduate School of Medical Sciences,; Kyushu University.
- Convergence of natural and artificial evolution on an RNA loop-loop interaction: the HIV-1 dimerization initiation site.
- RNA. 2000 Sep;6(9):1267-76. Unique Identifier : AIDSLINE MED/20452233
- Lodmell JS; Ehresmann C; Ehresmann B; Marquet R; Institut de Biologie Moleculaire et Cellulaire, Unite Propre de; Recherche 9002 du Centre National de la Recherche Scientifique,; Strasbourg, France.
- Loop-loop interactions among nucleic acids constitute an important form of molecular recognition in a variety of biological systems. In HIV-1, genomic dimerization involves an intermolecular RNA loop-loop interaction at the dimerization initiation site (DIS), a hairpin located in the 5 noncoding region that contains
- Coupled in vitro synthesis and splicing of RNA polymerase II transcripts.
- RNA. 2000 Sep;6(9):1325-34. Unique Identifier : AIDSLINE MED/20452238
- Ghosh S; Garcia-Blanco MA; Department of Genetics, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- Compelling in vivo studies suggest a tight functional linkage between RNA polymerase II transcription and premessenger RNA splicing. At present, the specific interactions involved in this coupling are poorly understood and deserve investigation. To this end, we developed an in vitro system that permits study of couple
- Reversible pulmonary hypertension in POEMS syndrome--another etiology of triggered pulmonary vasculopathy?
- Can J Cardiol. 2000 Aug;16(8):1007-12. Unique Identifier : AIDSLINE MED/20435621
- Paciocco G; Bossone E; Erba H; Rubenfire M; Instituto di Malattie dell'App Respiratorio, Italy.
- Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome, a plasma cell dyscrasia associated with pulmonary hypertension, has been treated in the past with anticytokine strategies with a poor outcome. A patient is described who had POEMS syndrome with precapillary pulmonary
- CAM and HIV/AIDS: the importance of complementarity [comment]
- Altern Ther Health Med. 2000 Sep;6(5):30-1. Unique Identifier : AIDSLINE MED/20433537
- Targ E; Complementary Medicine Research Institute, California Pacific; Medical Center, USA.
- Acupuncture for symptom relief in HIV-positive adults: lessons learned from a pilot study [see comments]
- Altern Ther Health Med. 2000 Sep;6(5):33-42. Unique Identifier : AIDSLINE MED/20433538
- Beal MW; Nield-Anderson L; Yale University School of Nursing, New Haven, Conn., USA.
- CONTEXT: Although acupuncture is used by many people with HIV disease as a complementary treatment to Western medicine, there is a lack of scientifically sound research on patient responses and outcomes. OBJECTIVE: To explore the feasibility of conducting a larger study investigating the efficacy of acupuncture on sym
- Alternative or complementary? Nonallopathic therapies for HIV/AIDS [see comments]
- Altern Ther Health Med. 2000 Sep;6(5):44-52. Unique Identifier : AIDSLINE MED/20433539
- de Visser R; Ezzy D; Bartos M; Australian Research Centre in Sex, Health, and Society, La Trobe; University, Melbourne.
- CONTEXT: Many people with HIV/AIDS use alternative therapies. Do they choose alternative therapies instead of allopathic therapies? OBJECTIVE: To examine patterns of use of allopathic therapies and alternative therapies among people living with HIV/AIDS. DESIGN: Cross-sectional survey of convenience sample. SETTING: N
- Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites.
- Cancer Res. 2000 Sep 1;60(17):4939-45. Unique Identifier : AIDSLINE MED/20441594
- Mori N; Ueda A; Ikeda S; Yamasaki Y; Yamada Y; Tomonaga M; Morikawa S; Geleziunas R; Yoshimura T; Yamamoto N; Department of Preventive Medicine and AIDS Research, Institute of; Tropical Medicine, Nagasaki University, Japan.; n-mori@net.nagasaki-u.ac.jp
- Infection by human T-cell leukemia virus type (HTLV) I leads to adult T-cell leukemia and is also associated with the neurodegenerative disease HTLV-I-associated myelopathy/tropical spastic paraparesis. Leukocytes are attracted to sites of inflammation by chemokines. One such chemokine is monocyte chemoattractant prot
- Local injections of OK432 can help the infiltration of adoptively transferred CD8+ T cells into the tumor sites and synergistically induce the local production of Th1-type cytokines and CXC3 chemokines.
- Cancer Immunol Immunother. 2000 Sep;49(7):361-8. Unique Identifier : AIDSLINE MED/20452091
- Tatsugami K; Tamada K; Abe K; Harada M; Nomoto K; Department of Immunology, Medical Institute of Bioregulation,; Kyushu University, Fukuoka, Japan.
- The effect of local injections with streptococcal preparation OK432 on the antitumor effect induced by adoptive immunotherapy (AIT) was investigated. Draining lymph node cells on day 14 after B7-P815 inoculation were used for AIT after in vitro stimulation. AIT on days 7 and 10 showed no effect on the growth of s.c. e
- How Latino American and European American adolescents discuss conflicts, sexuality, and AIDS with their mothers.
- Dev Psychol. 2000 May;36(3):315-25. Unique Identifier : AIDSLINE MED/20289822
- Lefkowitz ES; Romo LF; Corona R; Au TK; Sigman M; Department of Human Development and Family Studies, Pennsylvania; State University, University Park 16802, USA. EXL20@psu.edu
- The authors examined how the structure of mother-adolescent conversations differs by ethnic group, age, and dyadic and individual factors. Mother-adolescent dyads of European or Latino descent participated in conversations and reported on their relationship and AIDS knowledge. Latina American mothers dominated convers
- Positive influence of the Delta32CCR5 allele on response to highly active antiretroviral therapy (HAART) in HIV-1 infected patients.
- Eur J Med Res. 2000 Aug 18;5(8):323-8. Unique Identifier : AIDSLINE MED/20416402
- Kasten S; Goldwich A; Schmitt M; Rascu A; Grunke M; Dechant C; Kalden JR; Harrer T; Department of Medicine III, University of Erlangen-Nuremberg,; Krankenhausstrasse 12, D-91054 Erlangen, Germany.
- The heterozygous 32 base pair deletion of the chemokine receptor 5 (Delta32CCR5) has been associated with a more benign course of HIV-1-infection. To study the influence of Delta32CCR5 on the response to antiviral therapy we analyzed the presence of Delta32CCR5 by PCR in PBMC from 107 randomly selected HIV-1-infected
- Incidence of myocardial infarctions in HIV-infected patients between 1983 and 1998: the Frankfurt HIV-cohort study.
- Eur J Med Res. 2000 Aug 18;5(8):329-33. Unique Identifier : AIDSLINE MED/20416403
- Rickerts V; Brodt H; Staszewski S; Stille W; Klinikum der J.W. Goethe Universitat Frankfurt, Med. Klinik III; / Infektiologie, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.; Rickerts@em.uni-frankfurt.de
- OBJECTIVE: To investigate whether the use of highly active antiretroviral therapy (HAART) is associated with an increased incidence of myocardial infarctions (MI) in HIV infected patients. DESIGN: Retrospective analysis of a cohort of 4993 HIV infected patients treated at our hospital between January, 1 1983 and Decem
- Spleen necrosis virus-derived C-type retroviral vectors for gene transfer to quiescent cells.
- Nat Biotechnol. 2000 Jun;18(6):623-9. Unique Identifier : AIDSLINE MED/20296926
- Parveen Z; Krupetsky A; Engelstadter M; Cichutek K; Pomerantz RJ; Dornburg R; The Dorrance H. Hamilton Laboratories, Thomas Jefferson; University, Division of Infectious Diseases, Center for Human; Virology, 1020 Locust Street, Suite 329, Philadelphia, PA 19107,; USA.
- Gene therapy applications of retroviral vectors derived from C-type retroviruses have been limited to introducing genes into dividing target cells. Here, we report genetically engineered C-type retroviral vectors derived from spleen necrosis virus (SNV), which are capable of infecting nondividing cells. This has been
- Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5.
- Nat Biotechnol. 2000 Jun;18(6):649-54. Unique Identifier : AIDSLINE MED/20296931
- Mirzabekov T; Kontos H; Farzan M; Marasco W; Sodroski J; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, 44 Binney St., Boston, MA 02115, USA.
- Seven-transmembrane segment, G protein-coupled receptors play central roles in a wide range of biological processes, but their characterization has been hindered by the difficulty of obtaining homogeneous preparations of native protein. We have created paramagnetic proteoliposomes containing pure and oriented CCR5, a
- A randomised controlled trial of different approaches to universal antenatal HIV testing: uptake and acceptability and Annex: Antenatal HIV testing - assessment of a routine voluntary approach.
- Health Technol Assess. 1999;3(4):1-112. Unique Identifier : AIDSLINE MED/99279606
- Simpson WM; Johnstone FD; Boyd FM; Goldberg DJ; Hart GJ; Gormley SM; Hamilton BA; Department of Obstetrics and Gynaecology, Centre for Reproductive; Biology, The University of Edinburgh, Edinburgh, UK.
- Molecular localisation of a G-protein mRNA using differential display and in situ hybridization.
- Brain Res Brain Res Protoc. 2000 Jul;5(3):290-7. Unique Identifier : AIDSLINE MED/20368875
- Wilkinson R; Tscharke D; Simmons A; Infectious Diseases Laboratories, Institute of Medical and; Veterinary Science, Frome Road, South Australia 5000, Adelaide,; Australia. ray.wilkinson@imvs.sa.gov.au
- Defining molecular repertoires within virally infected tissues of the nervous system may provide insight into the pathogenesis of, and immunity to, neurotropic viruses. Here we report the application of such a method, namely mRNA differential display (DD), to the identification of mRNAs that are expressed at different
- [Polymorphism of human alleles associated with genetic resistance against HIV-1 infection and its implications]
- Chung Hua I Hsueh I Chuan Hsueh Tsa Chih. 2000 Aug;17(4):285-7. Unique Identifier : AIDSLINE MED/20392334
- Wang F; Liu D; Department of Bioengineering, Beijing Institute of Infectious; Diseases, P. R. China. fushengw@public.bta.net.cn
- To investigate the genetic susceptibility of different ethnic populations to human immunodeficiency virus-1(HIV-1) infection by comparing the characteristics of gene mutation frequency and polymorphism of CCR5, CCR2 and SDF-1 alleles among different nationalities in the world. The recently reported data on AIDS progre
- Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine.
- Altern Med Rev. 2000 Aug;5(4):290-305. Unique Identifier : AIDSLINE MED/20413353
- Patrick L
- The role of antioxidants in preventing apoptosis and viral activation in HIV is well documented. N-acetylcysteine, glutathione, and alpha-lipoic acid have been shown to interrupt the process of viral activation and CD4 cell death. L-glutamine has been shown to improve glutathione levels and significantly increase lean
- Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients [see comments]
- J Peripher Nerv Syst. 1997;2(3):250-2. Unique Identifier : AIDSLINE MED/20427471
- Scarpini E; Sacilotto G; Baron P; Cusini M; Scarlato G; Department of Clinical Neurology, IRCCS-Ospedale Maggiore; Policlinico, University of Milano, Italy.
- We studied the effects of acetyl-L-carnitine on pain in 16 HIV+ patients affected by painful distal symmetrical neuropathy. Patients were treated with 0.5-1 gr per day of acetyl-L-carnitine either i.m. or i.v. for 3 weeks. Pain intensity was measured before and after the treatment by the Huskisson s analogic scale. Te
- Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide.
- Cancer Chemother Pharmacol. 2000;46(2):135-41. Unique Identifier : AIDSLINE MED/20426299
- Kestell P; Zhao L; Baguley BC; Palmer BD; Muller G; Paxton JW; Ching LM; Auckland Cancer Society Research Centre, University of Auckland; Medical School, New Zealand.
- BACKGROUND: 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), an investigative drug currently in clinical trial, acts on tumour vasculature through the induction of cytokines. Coadministration of thalidomide, a modulator of cytokine production, potentiates the antitumour activity of DMXAA against the murine Colon 38 carci
- Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.
- Clin Immunol. 2000 Sep;96(3):187-97. Unique Identifier : AIDSLINE MED/20423206
- Laux I; Khoshnan A; Tindell C; Bae D; Zhu X; June CH; Effros RB; Nel A; Division of Clinical Immunology and Allergy, UCLA, Los Angeles,; California, 90095, USA.
- Since CD28 costimulation is critical for T-cell activation, there is great interest in CD28 as a target for immuntherapeutic approaches. We show that stimulation of human CD4(+) and CD8(+) T-cells differs in their responsiveness to stimulation with anti-CD3/CD28-coated beads, as surrogate antigen-presenting cells. Whi
- Combined nasal administration of encephalitogenic myelin basic protein peptide 68-86 and IL-10 suppressed incipient experimental allergic encephalomyelitis in Lewis rats.
- Clin Immunol. 2000 Sep;96(3):205-11. Unique Identifier : AIDSLINE MED/20423208
- Xu LY; Yang JS; Huang YM; Levi M; Link H; Xiao BG; Experimental Neurobiology Unit and Neuroimmunology Unit,; Karolinska Institute, Stockholm, Sweden.
- Mucosal administration of low doses of myelin basic protein (MBP) peptide 68-86 (MBP 68-86) or anti-inflammatory cytokine IL-10 effectively prevented experimental allergic encephalomyelitis (EAE), but failed to suppress the disease if given after 7 days postimmunization (p.i.), i.e., after T cell priming had occurred.
- The increase of IFN-gamma production through aging correlates with the expanded CD8(+high)CD28(-)CD57(+) subpopulation.
- Clin Immunol. 2000 Sep;96(3):230-5. Unique Identifier : AIDSLINE MED/20423211
- Bandres E; Merino J; Vazquez B; Inoges S; Moreno C; Subira ML; Sanchez-Ibarrola A; School of Medicine, Clinica Universitaria, Pamplona, Spain.
- The use of flow cytometry to detect intracellular cytokines at the single cell level has the potential to quantify cytokine production together with the possibility of phenotypic identification of the cell population concerned. The unbalanced presence of intracellular cytokines produced by T cells has been recognized
- N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.
- Clin Immunol. 2000 Sep;96(3):236-42. Unique Identifier : AIDSLINE MED/20423212
- Le Y; Jiang S; Hu J; Gong W; Su S; Dunlop NM; Shen W; Li B; Ming Wang J; Laboratory of Molecular Immunoregulation, National Cancer; Institute-Frederick Cancer Research and Development Center,; Frederick, Maryland, 21702, USA.
- Human immunodeficiency virus type 1 (HIV-1) envelope protein gp41 mediates viral fusion with human host cells. In this study we show that N36, a synthetic peptide derived from the N-terminus of gp41, induced directional migration and calcium mobilization in human monocytes and neutrophils. The activity of N36 on phago
- Activation of human microglial cells by HIV-1 gp41 and Tat proteins.
- Clin Immunol. 2000 Sep;96(3):243-51. Unique Identifier : AIDSLINE MED/20423213
- Sheng WS; Hu S; Hegg CC; Thayer SA; Peterson PK; Department of Pharmacology, Institute for Brain and Immune; Disorders, Minneapolis, Minnesota, 55404, USA.
- The viral proteins, Tat (HIV-1 nuclear protein) and gp41 (HIV-1 coat protein), detected in the brains of HIV-1-infected patients have been shown to be neurotoxic. We investigated the effects of HIV-1 Tat and gp41 proteins on cytokine, chemokine, and superoxide anion (O(-)(2)) production by microglia, the resident macr
- CD4 T lymphocyte activation in BLV-induced persistent B lymphocytosis in cattle.
- Clin Immunol. 2000 Sep;96(3):280-8. Unique Identifier : AIDSLINE MED/20423217
- Stone DM; Norton LK; Chambers JC; Meek WJ; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman, Washington, 99164-7040, USA.
- Bovine leukemia virus (BLV) is an oncogenic retrovirus in the human T cell leukemia virus family. BLV infects B lymphocytes and induces a nonmalignant persistent lymphocytosis (PL) and leukemia/lymphoma in cattle. There is evidence that CD4 T lymphocytes are activated during BLV infection and promote the development o
- Discrepancy between Ga-67 citrate and F-18 fluorodeoxyglucose positron emission tomographic scans in pulmonary infection.
- Clin Nucl Med. 2000 Jun;25(6):490-1. Unique Identifier : AIDSLINE MED/20294699
- Goswami GK; Jana S; Santiago JF; Buyukdereli G; Salem SS; Heiba S; Abdel-Dayem HM; Department of Radiology, Saint Vincents Hospital, New York; Medical College, Valhalla 10011, USA.
- The authors describe a patient with the acquired immunodeficiency syndrome who had active pulmonary tuberculosis and was receiving anti-tuberculosis treatment. High-grade fever and a right-sided pleural effusion had recently developed. Results of a Ga-67 scan were negative for any focal infection in the chest. Fluorin
- Rapid communication: development of in vitro resistance to macrophage-tropic- and T-cell-line-adapted HIV-1 strains among HIV-positive volunteers treated with highly active antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):197-202. Unique Identifier : AIDSLINE MED/20429896
- Castillo RC; Arango-Jaramillo S; John R; Turner BC; Zimmerman E; Schwartz DH; Department of Molecular Microbiology and Immunology, The Johns; Hopkins University, School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.
- We have described a peripheral blood mononuclear cell (PBMC) culture system in which control of endogenous virus and resistance to exogenous HIV-1 correlates with low viremia among HIV-1-positive people. Nineteen patients remained consistently resistant or susceptible for more than 5 years of follow-up. On the fifth y
- Polymerase chain reaction-based assay for antibody-mediated neutralization of HIV-1 reveals a population of nonneutralized virus undetected by conventional p24 assay.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):203-10. Unique Identifier : AIDSLINE MED/20429897
- Achkar JM; Wang XH; Nyambi P; Gorny MK; Zolla-Pazner S; Bandres JC; New York Veterans Affairs Medical Center and Departments of; Medicine and Pathology, New York University, New York City, New; York 10010, USA.
- To be successful with strategies involving passive immunization or the generation of neutralizing antibodies against HIV, it is crucial that we improve our understanding of the process of antibody-mediated HIV neutralization. We have used a neutralization assay based on polymerase chain reaction (PCR) that is more rap
- Mortality for liver disease in patients with HIV infection: a cohort study.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):211-7. Unique Identifier : AIDSLINE MED/20429898
- Puoti M; Spinetti A; Ghezzi A; Donato F; Zaltron S; Putzolu V; Quiros-Roldan E; Zanini B; Casari S; Carosi G; II Divisione di Malattie Infettive, Azienda Spedali Civili,; Brescia, Italy. puoti_brambilla@iol.it
- We undertook this study to assess the association between the various potential causes of liver disease in HIV-seropositive patients and mortality due to liver failure. Three hundred and eight in-hospital deaths were observed from 1987 to December 1995 in a prospectively followed cohort of 1894 HIV-seropositive patien
- Association of race and gender with HIV-1 RNA levels and immunologic progression.
- Unique Identifier : AIDSLINE MED/20429899
- Anastos K; Gange SJ; Lau B; Weiser B; Detels R; Giorgi JV; Margolick JB; Cohen M; Phair J; Melnick S; Rinaldo CR; Kovacs A; Levine A; Landesman S; Young M; Munoz A; Greenblatt RM; Montefiore Medical Center, Bronx, New York 10467, USA.; kanasto@aol.com
- CONTEXT: HIV-1 RNA and lymphocyte subset levels are the principal indications for antiretroviral treatment. Past reports have differed with regard to the effect of gender and race on these measures and in measures of disease progression. OBJECTIVE: To assess racial and gender differences in HIV-1 RNA levels and CD4+ l
- Economic evaluation of drug resistance genotyping for the adaptation of treatment in HIV-infected patients in the VIRADAPT study.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):227-31. Unique Identifier : AIDSLINE MED/20429900
- Chaix C; Grenier-Sennelier C; Clevenbergh P; Durant J; Schapiro JM; Dellamonica P; Durand-Zaleski I; Public Health, Henri Mondor, AP-HP, Paris, France.
- BACKGROUND: Costs of antiretroviral therapy for HIV-infected patients have increased at a time when most countries are attempting to contain health care costs. Part of this increase results from HIV drug resistance associated with virologic failure and a subsequent shift to more complex and costly therapies. Genotypic
- Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1-infected Italian patients with virologic failure.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):232-40. Unique Identifier : AIDSLINE +
- Balotta C; Violin M; Monno L; Bagnarelli P; Riva C; Facchi G; Berlusconi A; Lippi M; Rusconi S; Clementi M; Galli M; Angarano G; Moroni M; Institute of Infectious and Tropical Diseases, L. Sacco Hospital,; University of Milan, Milan, Italy. claudia.balotta@unimi.it
- We evaluated the prevalence of both Q151M and 6-bp insert at position 69 of RT region responsible for multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 variants in 177 patients who failed to respond to combination therapy . Patients had received
- Interaction of methadone with didanosine and stavudine.
- Unique Identifier : AIDSLINE MED/20429902
- Rainey PM; Friedland G; McCance-Katz EF; Andrews L; Mitchell SM; Charles C; Jatlow P
- For opiate-dependent injection drug users infected with HIV, methadone therapy may facilitate adherence to complex highly active antiretroviral therapy (HAART) regimens. Current HAART regimens include one or more nucleoside analogues. We investigated the effects of methadone on the pharmacokinetics of the tablet formu
- Prenatal zidovudine use and congenital anomalies in a medicaid population.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):249-56. Unique Identifier : AIDSLINE MED/20429903
- Newschaffer CJ; Cocroft J; Anderson CE; Hauck WW; Turner BJ; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 21205, USA.
- OBJECTIVES: To examine the association of prescribed zidovudine (ZDV) during pregnancy with congenital anomalies in a population-based cohort. METHODS: Medicaid claims were used to assess prescribed ZDV and children s major congenital anomalies in 1932 liveborn deliveries from 1993 to 1996 to HIV-infected women in the
- Lower HIV-2 plasma viral loads may explain differences between the natural histories of HIV-1 and HIV-2 infections.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):257-63. Unique Identifier : AIDSLINE MED/20429904
- Shanmugam V; Switzer WM; Nkengasong JN; Garcia-Lerma G; Green TA; Ekpini E; Sassan-Morokro M; Antunes F; Manshino K; Soriano V; Wiktor SZ; Heneine W; HIV and Retrovirology Branch, Division of HIV/AIDS, STDs, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
- To explain the low transmissibility and pathogenicity of HIV-2 infection s plasma viral loads in both HIV-1- and HIV-2-infected persons were compared by using the polymerase chain reaction (PCR)-based Amp-RT assay to measure levels of reverse transcriptase (RT) activity. The study comprised a total of 155 HIV-infected
- HIV-1-Specific CD4 helper function in persons with chronic HIV-1 infection on antiviral drug therapy as measured by ELISPOT after treatment with an inactivated, gp120-depleted HIV-1 in incomplete Freund's adjuvant.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):264-9. Unique Identifier : AIDSLINE MED/20429905
- Moss RB; Webb E; Giermakowska WK; Jensen FC; Savary JR; Wallace MR; Carlo DJ; The Immune Response Corporation, Carlsbad, California 92008, USA.; shotdoc@imnr.com
- OBJECTIVE: We hypothesized that treatment of HIV-1-seropositive study subjects receiving potent antiviral therapy with an HIV-specific immune-based therapy would increase HIV-1-specific T-helper immune function. DESIGN: 10 HIV-1-seropositive study subjects receiving antiretroviral therapy were treated with an inactiva
- Incidence and trends in Kaposi's sarcoma in the era of effective antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):270-4. Unique Identifier : AIDSLINE MED/20429906
- Jones JL; Hanson DL; Dworkin MS; Jaffe HW; Division of HIV/AIDS Prevention Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, National Center; for Infectious Diseases, Centers for Disease Control and; Prevention, Atlanta, GA 30341-3724, USA.
- OBJECTIVE: To evaluate the impact of antiretroviral and antiherpesvirus therapies on the incidence of KS and assess trends in incidence of Kaposi s sarcoma (KS) in a large multicenter HIV/AIDS surveillance system between 1990 and 1998. METHODS: Incidence was calculated per 100 person-years (py); the effects of therapi
- Factors affecting African-American participation in AIDS research.
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):275-84. Unique Identifier : AIDSLINE MED/20429907
- Sengupta S; Strauss RP; DeVellis R; Quinn SC; DeVellis B; Ware WB; Center for AIDS Prevention Studies, University of California, San; Francisco, California 94105, USA. ssengupta@psg.ucsf.edu
- BACKGROUND: Although African Americans are disproportionately affected by the AIDS epidemic, they are underrepresented in AIDS research, particularly in AIDS clinical trials. This study examines a multidimensional construct of distrust and other factors that may affect willingness to participate in AIDS research. METH
- Age-dependent expression of the HIV-1 coreceptor CCR5 on CD4+ lymphocytes in children [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):285-7. Unique Identifier : AIDSLINE MED/20429908
- Auewarakul P; Sangsiriwut K; Pattanapanyasat K; Wasi C; Lee TH
- Preliminary experience of adverse drug reactions, tolerability, and efficacy of a once-daily regimen of antiretroviral combination therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):287-8. Unique Identifier : AIDSLINE MED/20429909
- Hsieh SM; Hung CC; Lu PL; Chen MY; Chang SC
- Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogenous leukemia [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):289-90. Unique Identifier : AIDSLINE MED/20429910
- Schlegel P; Beatty P; Halvorsen R; McCune J
- Microsporidiosis and HIV [letter]
- Unique Identifier : AIDSLINE MED/20429911
- Dascomb K; Frazer T; Clark RA; Kissinger P; Didier E
- Serotype, parental country of birth, and ethnic status in unlinked anonymous neonatal HIV seroprevalence surveys [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):292-4. Unique Identifier : AIDSLINE MED/20429912
- Ades AE; Parker S; Walker J; Weber JN
- Surveillance of antiretroviral prescriptions [letter]
- J Acquir Immune Defic Syndr. 2000 Jul 1;24(3):294. Unique Identifier : AIDSLINE MED/20429913
- Dworkin MS; Wan PC
- [HIV post-exposure prevention. Minutes are important--therefore PEP (postexposure prophylaxis) emergency set]
- MMW Fortschr Med. 2000;142(3 Suppl):10. Unique Identifier : AIDSLINE MED/20352415
- [Preventing AIDS. Cool--the condom campaign]
- MMW Fortschr Med. 2000;142(3 Suppl):11. Unique Identifier : AIDSLINE MED/20352416
- [A child despite HIV? Starting a family is not a taboo any more]
- MMW Fortschr Med. 2000;142(3 Suppl):12-3. Unique Identifier : AIDSLINE MED/20352417
- Paukstadt W
- [Need for review in research and practice. HIV infection in women is increasing]
- MMW Fortschr Med. 2000;142(3 Suppl):14-5. Unique Identifier : AIDSLINE MED/20352418
- [Lipodystrophy syndrome. After 3 years every third patient has lost his fat]
- MMW Fortschr Med. 2000;142(3 Suppl):16-7. Unique Identifier : AIDSLINE MED/20459980
- [Nutritional therapy in HIV infection. Many approaches, meager data]
- MMW Fortschr Med. 2000;142(3 Suppl):17-8. Unique Identifier : AIDSLINE MED/20459981
- Scharmer U
- [Almost 6,000 double-infected patients in Germany. Hepatitis C burden in HIV patients]
- MMW Fortschr Med. 2000;142(3 Suppl):19. Unique Identifier : AIDSLINE MED/20352419
- [Standards, trends and challenges in HIV medicine (editorial)]
- MMW Fortschr Med. 2000;142(3 Suppl):2. Unique Identifier : AIDSLINE MED/20352410
- Paukstadt W
- [Highly active antiretroviral therapy. A simple combination, but high effectiveness]
- MMW Fortschr Med. 2000;142(3 Suppl):20-2. Unique Identifier : AIDSLINE MED/20352420
- [Safety in routine clinical practice. Hypersensitivity can be managed]
- MMW Fortschr Med. 2000;142(3 Suppl):22-3. Unique Identifier : AIDSLINE MED/20352421
- [Discussed with a current case: physician confidentiality issue in conflict]
- MMW Fortschr Med. 2000;142(3 Suppl):24-5. Unique Identifier : AIDSLINE MED/20352422
- Paukstadt W
- [Controlled tapering of medication. What do structured treatment withdrawal achieve?]
- MMW Fortschr Med. 2000;142(3 Suppl):25-6. Unique Identifier : AIDSLINE MED/20352423
- [Daily routine in an HIV specialty practice. Ambulatory patient monitoring (interview by Waldtraut Paukstadt)]
- MMW Fortschr Med. 2000;142(3 Suppl):27. Unique Identifier : AIDSLINE MED/20352424
- Golz J
- [Choice of first-line therapy. It depends on long-term effectiveness]
- MMW Fortschr Med. 2000;142(3 Suppl):28-9. Unique Identifier : AIDSLINE MED/20352425
- [Less is more--what counts is the number of tablets. Looking at antiretroviral substances]
- MMW Fortschr Med. 2000;142(3 Suppl):3-5. Unique Identifier : AIDSLINE MED/20352411
- Paukstadt W
- [Long-term success in routine clinical practice. Effectiveness trial passed]
- MMW Fortschr Med. 2000;142(3 Suppl):30-1. Unique Identifier : AIDSLINE MED/20352426
- [HIV therapy from the viewpoint of the patient. Four out of five suffer with side-effects]
- MMW Fortschr Med. 2000;142(3 Suppl):32-3. Unique Identifier : AIDSLINE MED/20352427
- Wepner U
- [New therapy approaches for HIV infected patients. Hope on the immune front]
- MMW Fortschr Med. 2000;142(3 Suppl):33. Unique Identifier : AIDSLINE MED/20352428
- [Non-nucleoside reverse transcriptase inhibitors. First line therapy]
- MMW Fortschr Med. 2000;142(3 Suppl):34-5. Unique Identifier : AIDSLINE MED/20352429
- [Effectiveness also in general practice conditions. Just as good in routine practice as in studies]
- MMW Fortschr Med. 2000;142(3 Suppl):36-7. Unique Identifier : AIDSLINE MED/20352430
- [Switch strategy: replacing the protease inhibitor. Quality of life improves]
- MMW Fortschr Med. 2000;142(3 Suppl):37. Unique Identifier : AIDSLINE MED/20459982
- [Looking at the HIV test. Qualitative virus detection a cost-effective alternative?]
- MMW Fortschr Med. 2000;142(3 Suppl):38. Unique Identifier : AIDSLINE MED/20352431
- Scharmer U
- [New generation protease inhibitor. Tolerance and potency, a tight association]
- MMW Fortschr Med. 2000;142(3 Suppl):40-1. Unique Identifier : AIDSLINE MED/20352432
- [Ritonavir/Saqinavir: dual protease inhibitor combination. Salvage therapy]
- MMW Fortschr Med. 2000;142(3 Suppl):41. Unique Identifier : AIDSLINE MED/20459983
- [Administer a protease inhibitor immediately? Proceeding strategically in HIV therapy]
- MMW Fortschr Med. 2000;142(3 Suppl):6-7. Unique Identifier : AIDSLINE MED/20352412
- [Holding option open for subsequent treatment. Beginning therapy with a protease inhibitor]
- MMW Fortschr Med. 2000;142(3 Suppl):8-9. Unique Identifier : AIDSLINE MED/20352413
- [Living with HIV therapy. Side effects are the main problem]
- MMW Fortschr Med. 2000;142(3 Suppl):9. Unique Identifier : AIDSLINE MED/20352414
- HTLV-I associated infective dermatitis may be an indolent HTLV-I associated lymphoma.
- Braz J Infect Dis. 2000 Apr;4(2):100-2. Unique Identifier : AIDSLINE MED/20259838
- Goncalves DU; Guedes AC; Carneiro-Proietti AB; Lambertucci JR; Departments of Internal Medicine,Dermatology, Ophthalmology,; Preventive and Social Medicine, Federal University of Minas; Gerais.
- When present for a first time blood donation, a 28-year-old Brazilian white female reported a pruritic eczema of the scalp and retroauricular areas since childhood that had been frequently infected. Her mother had been diagnosed as having HTLV-I-associated myelopathy (HAM), and the patient was found to be a human T-ly
- Changing strategies for treatment of systemic mycoses.
- Braz J Infect Dis. 2000 Apr;4(2):47-54. Unique Identifier : AIDSLINE MED/20464221
- Graybill JR; Department of Medicine, Veterans Administration Hospital, San; Antonio, TX 78284, USA.
- There have been a number of changes in strategies in antifungal therapy in the past few years. AIDS related mycoses have decreased, and the increase of fluconazole resistant Candida albicans may be slowing because fewer severely immune depressed patients require constant fluconazole suppression. Candida species contin
- Infectious and neoplastic disorders of the thyroid in AIDS patients: an autopsy study.
- Braz J Infect Dis. 2000 Apr;4(2):67-75. Unique Identifier : AIDSLINE MED/20259834
- Basilio-De-Oliveira CA; Department of Pathology, Gaffree and Guinle University Hospital,; University of Rio de Janeiro (Uni-Rio), Rio de Janeiro, RJ,; Brazil.
- The course of human immunodeficiency virus infection and the acquired immunodeficiency syndrome can be complicated by a variety of endocrine abnormalities. This article describes the findings of a prospective autopsy study of 100 AIDS patients with thyroids compromised by infectious agents or neoplastic disorders from
- A retrospective bacteriological study of mycobacterial infections in patients with acquired immune deficiency syndrome (AIDS).
- Braz J Infect Dis. 2000 Apr;4(2):86-90. Unique Identifier : AIDSLINE MED/20259836
- de C Ramos M; Jacques De Moraes M; Calusni AL; Roscani GN; Picolli Alves E; Clinical Hospital of the State University of Campinas (UNICAMP),; School of Medical Sciences, Campinas, Sao Paulo, Brazil.
- The main species of mycobacteria isolated in 51 patients with acquired immune deficiency syndrome (AIDS) admitted to the Clinical Hospital of UNICAMP (Teaching Hospital) in 1996, were studied retrospectively by recording the isolation site and signs of pathogenesis. Of these isolates, 31 (55%) were M.tuberculosis and
- Lipodystrophy and altered body shape in HIV: a protease inhibitor side effect? What do you tell your patient?
- Case Manager. 1999 Jan-Feb;10(1):45-7; quiz 49. Unique Identifier : AIDSLINE MED/20456008
- Thorn K; Thorn and Associates, Canoga Park, Calif., USA.
- Contact lens considerations for patients infected with HIV.
- Optometry. 2000 Apr;71(4):249-58. Unique Identifier : AIDSLINE MED/20430624
- Chronister CL; Pennsylvania College of Optometry, Philadelphia, USA.
- BACKGROUND: As an eye care practitioner, one must be aware of the many sequelae of HIV disease and its impact on contact lens patients. With the progressing development of anti-HIV medications, patients infected with HIV are living longer and more productive lives. Thus a greater number of patients infected with HIV m
- Use of computer-assisted rescreening as an ancillary tool to subclassify AGUS cervical smears.
- Diagn Cytopathol. 2000 Sep;23(3):165-70. Unique Identifier : AIDSLINE MED/20403951
- Chhieng DC; Elgert PA; Xiong Y; Cangiarella JF; Cohen JM; Department of Pathology, New York University Medical Center, New; York, USA.
- A substantial percentage of women with a diagnosis of atypical glandular cells of undetermined significance (AGUS) on cervical smears harbor a significant squamous or glandular, preneoplastic or neoplastic lesion on subsequent follow-up. Attempts to subclassify AGUS smears by conventional methods have had mixed result
- Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.
- EMBO J. 2000 Aug 1;19(15):3956-67. Unique Identifier : AIDSLINE MED/20380930
- Hrimech M; Yao XJ; Branton PE; Cohen EA; Laboratoire de Retrovirologie Humaine, Departement de; microbiologie et immunologie, Faculte de medecine, Universite; de Montreal, Montreal, Quebec, Canada H3C 3J7.
- The Vpr protein of primate lentiviruses arrests cell cycling at the G(2)/M phase through an inactivation of cyclin B-p34(cdc2) and its upstream regulator cdc25. We provide here biochemical and functional evidence demonstrating that human immunodeficiency virus type 1 (HIV-1) Vpr mediates G(2) arrest by forming a compl
- Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active.
- Eur J Biochem. 2000 Aug;267(15):4740-4. Unique Identifier : AIDSLINE MED/20363704
- Werner S; Wohrl BM; Max-Planck-Institut fur molekulare Physiologie, Abteilung; Physikalische Biochemie, Dortmund, Germany.
- Heterodimeric reverse transcriptase (RT) alphabeta from Rous sarcoma virus (RSV) possesses an asymmetric subunit organization with the polymerase and RNase H active sites localized in the alpha subunit. To determine whether homodimeric RSV RTs alpha (63 kDa) or beta (95 kDa) assume alpha subunit organization similar t
- Divalent metal cation binding properties of human prothymosin alpha.
- Eur J Biochem. 2000 Aug;267(15):4745-52. Unique Identifier : AIDSLINE MED/20363705
- Chichkova NV; Evstafieva AG; Lyakhov IG; Tsvetkov AS; Smirnova TA; Karapetian RN; Karger EM; Vartapetian AB; Belozersky Institute of Physico-Chemical Biology and Center of; Molecular Medicine, Moscow State University, Russia.
- The divalent cation binding properties of human prothymosin alpha, an abundant nuclear protein involved in cell proliferation, were evaluated. By using prothymosin alpha retardation on a weak cation chelating resin charged with various divalent cations, specific binding of Zn2+ ions by prothymosin alpha was observed.
- Simulation of electrostatic effects in Fab-antigen complex formation.
- Eur J Biochem. 2000 Aug;267(15):4861-9. Unique Identifier : AIDSLINE MED/20363718
- Fogolari F; Ugolini R; Molinari H; Viglino P; Esposito G; Dipartimento Scientifico e Tecnologico, Universita di Verona,; Italy. fogolari@sci.univr.it
- A model based on the Poisson-Boltzmann equation has been used to model electrostatics in Anti-p24 (HIV-1) Fab-antigen association. The ionization state at different pH values has been simulated and the results have been used to estimate the stability at different pH values and to generate electrostatic potential maps
- Squamous intraepithelial lesions (SILs) and HPV associated changes in HIV infected women or at risk of HIV. DIANAIDS Cooperative Study Group.
- Eur J Gynaecol Oncol. 2000;21(2):155-9. Unique Identifier : AIDSLINE MED/20300461
- Branca M; Migliore G; Giuliani MLeoncini L; Ippolito G; Cappiello G; Garbuglia AR; Schiesari A; Rezza G; Cytopathology Unit, National Institute of Health, Rome, Italy.
- OBJECTIVES: The study concerns the prevalence of squamous intraepithelial lesions (SILs) and the specific cervical cytopathological features of a group of HIV-positive and a group of HIV-negative women recruited in a multicentric cohort study. The assessment of HPV-DNA genotypes was carried out in both groups. METHOD:
- Colposcopy, cytology and HPV-DNA testing in HIV-positive and HIV-negative women.
- Eur J Gynaecol Oncol. 2000;21(2):168-72. Unique Identifier : AIDSLINE MED/20300464
- Torrisi A; Del Mistro A; Onnis GL; Merlin F; Bertorelle R; Minucci D; Institute of Gynaecology and Obstetrics, University of Padua,; Italy.
- In this study we examined the incidence of colposcopic-colpocytologic findings and analyzed Human Papilloma Virus (HPV)-DNA testing by Polymerase Chain Reaction (PCR) in 104 Human Immunodeficiency Virus (HIV) serous positive women (Group 1) and 218 HIV-negative women (control Groups 2 and 3). The aim of the study was
- The role of gammadelta T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodeficiency virus infection.
- Eur J Immunol. 2000 Aug;30(8):2245-56. Unique Identifier : AIDSLINE MED/20400241
- Lehner T; Mitchell E; Bergmeier L; Singh M; Spallek R; Cranage M; Hall G; Dennis M; Villinger F; Wang Y; Department of Immunobiology, Guy's, King's and St. Thomas'; Hospital Medical School, London, GB. thomas.lehner@kcl.ac.uk
- In view of the role of gammadelta(+) T cells in mucosal protection against infection, the proportion of gamma delta T cells was examined in cells eluted from lymphoid and mucosal tissues of macaques immunized with simian immunodeficiency virus (SIV) gp120 and p27 in alum and challenged with live SIV by the rectal muco
- Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production.
- Unique Identifier : AIDSLINE MED/20400250
- Richards DF; Fernandez M; Caulfield J; Hawrylowicz CM; Department of Respiratory Medicine and Allergy, The Guy's, King's; College and St. Thomas' Hospitals School of Medicine, London, GB.
- Glucocorticoids are highly effective in the treatment of allergy and asthma and inhibit the synthesis of IL-4, IL-5 and IL-13 by disease-promoting CD4(+) Th2 cells. CD8(+) T cells also synthesize these cytokines, and the aim of this study was to investigate how glucocorticoids effect cytokine production by these cells
- Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin.
- Eur J Immunol. 2000 Aug;30(8):2355-61. Unique Identifier : AIDSLINE MED/20400251
- Papadopoulos EJ; Fitzhugh DJ; Tkaczyk C; Gilfillan AM; Sassetti C; Metcalfe DD; Hwang ST; Dermatology Branch, National Cancer Institute, Bethesda, MD; 20892-1908, USA.
- Mast cells (MC) are anatomically located near nerves and blood vessels in skin and the gastrointestinal tract and tend to localize within certain cutaneous tumors such as neurofibromas. However, the molecular mechanisms by which MC home to these sites are not well characterized. Fractalkine (FK) is a membrane-bound CX
- Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming.
- Eur J Immunol. 2000 Aug;30(8):2394-403. Unique Identifier : AIDSLINE MED/20400256
- Gagliardi MC; Sallusto F; Marinaro M; Langenkamp A; Lanzavecchia A; De Magistris MT; Laboratory of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita, Rome, Italy.
- Cholera toxin (CT) is a potent mucosal adjuvant that amplifies B and T cell responses to mucosally co-administered antigens, stimulating predominant Th2-type responses. However, little is known about the mechanism of adjuvanticity of CT and on the influence this toxin may have on Th2 cell development during the primin
- Endoscopic features of smooth muscle tumors in children with AIDS.
- Gastrointest Endosc. 2000 Jul;52(1):91-4. Unique Identifier : AIDSLINE MED/20341268
- Molle ZL; Moallem H; Desai N; Anderson V; Rabinowitz SS; Divisions of Pediatric GI & Nutrition, Allergy and Immunology,; Pediatric Infectious Diseases, and Pathology, SUNY Health Science; Center at Brooklyn, NY, USA.
- BACKGROUND: Smooth muscle tumors are the second most common malignancy encountered in children with acquired immunodeficiency syndrome (AIDS). This study reviewed the incidence and endoscopic appearance of smooth muscle tumors in the gastrointestinal tract of children with AIDS undergoing endoscopy. METHODS: Retrospec
- Isolation and characterization of the human cyclin T1 promoter.
- Gene. 2000 Jul 11;252(1-2):39-49. Unique Identifier : AIDSLINE GENBANK/AF255307
- Liu H; Rice AP; Division of Molecular Virology, Baylor College of Medicine, One; Baylor Plaza, 77030, Houston, TX, USA.
- Cyclin T1 (CycT1) is a regulatory subunit of a general RNA polymerase II (RNAP II) elongation factor termed P-TEFb. The human immunodeficiency virus Tat protein directly associates with CycT1 to utilize CycT1/P-TEFb (also called TAK) for activation of RNAP II elongation of the integrated proviral genome. CycT1 mRNA an
- Genomic organization and characterization of promoter function of the human CDK9 gene.
- Gene. 2000 Jul 11;252(1-2):51-9. Unique Identifier : AIDSLINE GENBANK/AF255306
- Liu H; Rice AP; Division of Molecular Virology, Baylor College of Medicine, One; Baylor Plaza, 77030, Houston, TX, USA.
- CDK9 is the catalytic subunit of a general RNA polymerase II (RNAP II) elongation factor termed p-TEFb which is targeted by the human immunodeficiency virus (HIV) Tat protein to activate elongation of the integrated proviral genome. CDK9 mRNA and protein levels have been observed to be induced in activated peripheral
- Rapid progression of primary vaginal squamous cell carcinoma in a young HIV-infected woman.
- Gynecol Oncol. 2000 Sep;78(3 Pt 1):380-2. Unique Identifier : AIDSLINE MED/20442204
- Lee YC; Holcomb K; Buhl A; Holden J; Abulafia O; Division of Gynecologic Oncology, State University of New York; Health Science Center at Brooklyn, Brooklyn, New York 11203, USA.
- BACKGROUND: The association of human immunodeficiency virus (HIV) infection with rapid progression of cervical and anal squamous cell carcinoma has been clearly established by several studies. Human papilloma virus (HPV) infection of the anogenital tract is believed to be the causative agent of cervical, anal, vaginal
- [Equine Rhodococcus equi pneumonia: first report in Israel and its significance for man]
- Harefuah. 1999 Sep;137(5-6):202-4, 262. Unique Identifier : AIDSLINE MED/20415224
- Steinman A; Sutton GA; Elad D; Koret School of Veterinary Medicine, Hebrew University of; Jerusalem.
- Rhodococcus equi is an important pathogen in young horses. In recent years it has been increasingly recognized as an opportunistic infectious agent in patients with immune deficiency. The increase in recognized cases may be related to the increased prevalence of AIDS. However, more cases may have been recognized latel
- Effects of case management and new drugs on Medicaid AIDS spending.
- Health Aff (Millwood). 2000 Jul-Aug;19(4):233-43. Unique Identifier : AIDSLINE MED/20373691
- Mitchell JM; Anderson KH; Georgetown University Public Policy Institute in Washington,; D.C., USA.
- This study evaluates the effects of Florida s participation in the Medicaid acquired immunodeficiency syndrome (AIDS) home and community-based waiver and the use of recently developed AIDS drugs on spending per Medicaid beneficiary. We find that monthly Medicaid spending for waiver non-participants was significantly h
- Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: decreased risk for Hp0 individuals.
- Hum Hered. 2000 Nov-Dec;50(6):382-3. Unique Identifier : AIDSLINE MED/20359324
- Quaye IK; Ekuban FA; Brandful JA; Gyan BA; Akanmori BD; Ankrah NA; Noguchi Memorial Institute for Medical Research University of; Ghana, Legon, Accra, Ghana. noguchi@ncs.com.gh
- Plasma haptoglobin phenotypes were determined by polyacrylamide gel electrophoresis, followed by benzidine staining for 58 HIV-1 seropositive Ghanaians and 79 randomly selected age-matched controls. Hp0 was present in only 14% of HIV-1 seropositive individuals compared with more than 40% of the controls. The Hp0 indiv
- HTLV-I infection among Nivkhi people in Sakhalin: comparative serologic and phylogenetic analyses for 9 years.
- Int J Cancer. 2000 Aug 1;87(3):379-81. Unique Identifier : AIDSLINE MED/20357201
- Syrtsev AV; Yamashita M; Senyuta NB; Susova OY; Hayami M; Gurtsevitch VE; Laboratory of Viral Carcinogenesis, Institute of Carcinogenesis,; N.N. Blokhin Cancer Research Center, Moscow, Russia.
- Evaluation of CD8(+) T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with tyrosinase peptide.
- Int J Cancer. 2000 Aug 1;87(3):391-8. Unique Identifier : AIDSLINE MED/20357203
- Lewis JJ; Janetzki S; Schaed S; Panageas KS; Wang S; Williams L; Meyers M; Butterworth L; Livingston PO; Chapman PB; Houghton AN; Swim Across America Laboratory, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021, USA. lewisj@mskcc.org
- The lack of reproducible, quantitative assays for T-cell responses has been a limitation in the development of cancer vaccines to elicit T-cell immunity. We utilized the Elispot assay, which allows a quantitative and functional assessment of T cells directed against specific peptides after only brief in vitro incubati
- An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells.
- Int J Cancer. 2000 Oct 1;88(1):115-20. Unique Identifier : AIDSLINE MED/20419975
- Hombach A; Schneider C; Sent D; Koch D; Willemsen RA; Diehl V; Kruis W; Bolhuis RL; Pohl C; Abken H; Klinik I fur Innere Medizin, Labor Tumorgenetik, Universitat zu; Koln, Koln, Germany.
- Recombinant T-cell receptors with antibody-like specificity for tumor-associated antigens are successfully used to direct the cytolytic activity of T cells toward tumor cells. Clinical application, however, needs to comply with the low immunogenicity of the recombinant receptor, efficient gene transfer into peripheral
- Women, drugs and HIV/AIDS: results of a multicentre European study.
- Int J Epidemiol. 2000 Aug;29(4):734-43. Unique Identifier : AIDSLINE MED/20382770
- Estebanez PE; Russell NK; Aguilar MD; Beland F; Zunzunegui MV; Departamento de Salud Publica, Universidad Miguel Hernandez,; San Juan de Alicante, Spain. mdm.sec-admin@apdo.com
- BACKGROUND: In the light of rising human immunodeficiency virus (HIV) incidence rates amongst women in Western Europe, a multicentred, cross-sectional study was undertaken to explore the multitude of possible factors associated with HIV in a population of female injecting drug users (IDU). METHODS: Face-to-face interv
- Editorial commentary regarding prevention of blood borne diseases in the health care setting (Sep/Oct '99) [letter]
- Ir Med J. 1999 Nov-Dec;92(7):440. Unique Identifier : AIDSLINE MED/20423581
- Molloy C
- A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
- J Biol Chem. 2000 Aug 25;275(34):25985-92. Unique Identifier : AIDSLINE MED/20408936
- Sabroe I; Peck MJ; Van Keulen BJ; Jorritsma A; Simmons G; Clapham PR; Williams TJ; Pease JE; Leukocyte Biology Section, Biomedical Sciences Division, Sir; Alexander Fleming Building, Imperial College School of Medicine,; South Kensington, London SW7 2AZ, United Kingdom.
- We describe a small molecule chemokine receptor antagonist, UCB35625 (the trans-isomer J113863 published by Banyu Pharmaceutical Co., patent WO98/04554), which is a potent, selective inhibitor of CCR1 and CCR3. Nanomolar concentrations of UCB35625 were sufficient to inhibit eosinophil shape change responses to MIP-1al
- Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.
- J Biol Chem. 2000 Aug 25;275(34):26309-15. Unique Identifier : AIDSLINE MED/20408979
- Rosenkilde MM; Kledal TN; Holst PJ; Schwartz TW; Laboratory for Molecular Pharmacology, Department of; Pharmacology, The Panum Institute, University of Copenhagen,; DK-2200 Copenhagen, Denmark.
- Open reading frame 74 (ORF74) encoded by human herpesvirus 8 is a highly constitutively active seven transmembrane (7TM) receptor stimulated by angiogenic chemokines, e.g. growth-related oncogene-alpha, and inhibited by angiostatic chemokines e.g. interferon-gamma-inducible protein. Transgenic mice expressing ORF74 un
- Targeted drug delivery to C6 glioma by transferrin-coupled liposomes.
- J Biomed Mater Res. 2000 Jul;51(1):10-4. Unique Identifier : AIDSLINE MED/20273883
- Eavarone DA; Yu X; Bellamkonda RV; Biomaterials, Cell and Tissue Engineering Laboratory, Department; of Biomedical Engineering, Case Western Reserve University, 10900; Euclid Avenue, Cleveland, Ohio 44106, USA.
- Recent advances in liposome technology have shown promise relative to the introduction of chemotherapeutic agents with reduced toxicity, extended longevity, and potential for cell-specific targeting. In this study we report the engineering of a liposomal delivery system for the chemotherapeutic drug doxorubicin. The s
- HTLV-1 infections.
- Unique Identifier : AIDSLINE MED/20457860
- Bangham CR
- Human T lymphotropic virus type 1 (HTLV-1) causes disabling and fatal diseases, yet there is no vaccine, no satisfactory treatment, and no means of assessing the risk of disease or
- Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7.
- J Clin Pathol. 2000 Aug;53(8):612-4. Unique Identifier : AIDSLINE MED/20457866
- Mattes FM; McLaughlin JE; Emery VC; Clark DA; Griffiths PD; Department of Virology, Royal Free and University College Medical; School, London, UK. mattes@rfhsm.ac.uk
- BACKGROUND: Cytomegalovirus ( CMV ) is the prototype member of the beta-herpesvirinae, which can cause multiple organ dysfunction in the immunocompromised host. Human herpesvirus 6 (HHV-6) and HHV-7 are newer members of the beta-herpesvirinae that can cause febril
- Some problems found in HIV-1 RNA quantification [letter]
- J Clin Pathol. 2000 Aug;53(8):645-6. Unique Identifier : AIDSLINE MED/20457879
- Yoshida S; Yusa N; Sato N; Goto M; Iwamoto A
- The senescence-accelerated mouse shows aging-related defects in cellular but not humoral immunity against influenza virus infection.
- J Infect Dis. 2000 Aug;182(2):391-6. Unique Identifier : AIDSLINE MED/20375027
- Dong L; Mori I; Hossain MJ; Kimura Y; Department of Microbiology, Fukui Medical University School of; Medicine, Fukui, Japan.
- The senescence-accelerated mouse (SAM) strain P1, which has a short life span, was adopted as a murine model for an investigation of the pathogenesis of viral infection in elderly adults. After intranasal inoculation with influenza A virus, the SAM-P1 mice showed a higher rate of mortality, with prolonged virus growth
- Detection of a major gene predisposing to human T lymphotropic virus type I infection in children among an endemic population of African origin.
- J Infect Dis. 2000 Aug;182(2):405-12. Unique Identifier : AIDSLINE MED/20375029
- Plancoulaine S; Gessain A; Joubert M; Tortevoye P; Jeanne I; Talarmin A; de The G; Abel L; INSERM U436, "Modelisation Mathematique et Statistique en; Biologie et Medecine," CHU Pitie Salpetriere, Unite; d'Epidemiologie des Virus Oncogenes, Institut Pasteur, Paris,; France.
- Human T lymphotropic virus type I (HTLV-I) is a human oncoretrovirus that causes an adult T cell leukemia/lymphoma and a chronic neuromyelopathy. To investigate whether familial aggregation of HTLV-I infection (as determined by specific seropositive status) could be explained in part by genetic factors, we conducted a
- The CCR5Delta32 allele slows disease progression of human immunodeficiency virus-1-infected children receiving antiretroviral treatment.
- J Infect Dis. 2000 Aug;182(2):413-9. Unique Identifier : AIDSLINE MED/20375030
- Barroga CF; Raskino C; Fangon MC; Palumbo PE; Baker CJ; Englund JA; Spector SA; Department of Pediatrics, University of California San Diego, La; Jolla, CA 92093-0672, USA.
- The role of the CCR5Delta32 allele in human immunodeficiency virus (HIV)-1-related disease progression was analyzed for 457 antiretroviral-naive children who had participated in the Pediatric AIDS Clinical Trials Group 152 study, which demonstrated that didanosine (ddI) or zidovudine + ddI treatments were superior to
- Correlation between human immunodeficiency virus genotypic resistance and virologic response in patients receiving nelfinavir monotherapy or nelfinavir with lamivudine and zidovudine.
- J Infect Dis. 2000 Aug;182(2):420-7. Unique Identifier : AIDSLINE MED/20375031
- Atkinson B; Isaacson J; Knowles M; Mazabel E; Patick AK; Agouron Pharmaceuticals, Inc., San Diego, California, 92121, USA.
- The relationship between detectable human immunodeficiency virus (HIV) genotypic resistance and virologic response was compared in patients receiving nelfinavir as monotherapy (16 weeks) or in combination with lamuvidine and zidovudine (48 weeks). Two patient groups were defined on the basis of the presence or absence
- Pooled analysis of 3 randomized, controlled trials of interleukin-2 therapy in adult human immunodeficiency virus type 1 disease.
- J Infect Dis. 2000 Aug;182(2):428-34. Unique Identifier : AIDSLINE MED/20375032
- Emery S; Capra WB; Cooper DA; Mitsuyasu RT; Kovacs JA; Vig P; Smolskis M; Saravolatz LD; Lane HC; Fyfe GA; Curtin PT; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW 2010, Australia. semery@nchecr.unsw.edu.au.
- We collected human immunodeficiency virus (HIV) disease progression, survival, most recent CD4 cell count, and plasma HIV RNA levels from patients (n=157) who participated in randomized clinical trials of interleukin (IL)-2 that commenced before 1995. Data were available for 155 (99%) patients. Statistical analyses we
- Evaluation of CD4+ T cell function In vivo in HIV-infected patients as measured by bacteriophage phiX174 immunization.
- J Infect Dis. 2000 Aug;182(2):435-41. Unique Identifier : AIDSLINE MED/20375033
- Fogelman I; Davey V; Ochs HD; Elashoff M; Feinberg MB; Mican J; Siegel JP; Sneller M; Lane3 HC; Biologic Consulting, Inc., Edgewater, MD 21037, USA.; ilanafog@aol. com
- Bacteriophage phiX174 immunization was used to measure CD4(+) T cell function in vivo in human immunodeficiency virus (HIV)-infected patients across all disease stages. Function was evaluated by measuring the ability of T cells to provide help to B cells in antibody production, amplification, and isotype switching. A
- Human immunodeficiency virus type 1 subtype E envelope recombinant peptides containing naturally immunogenic epitopes.
- J Infect Dis. 2000 Aug;182(2):442-50. Unique Identifier : AIDSLINE MED/20375034
- Chang SY; Vithayasai V; Vithayasai P; Essex M; Lee TH; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115, USA.
- A series of recombinant peptides of the human immunodeficiency virus type 1 (HIV-1) subtype E envelope were used to address the question of whether immunogenic epitopes similar to those described for the subtype B envelope are also present in structurally analogous regions of another HIV-1 subtype with divergent seque
- Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans.
- J Infect Dis. 2000 Aug;182(2):451-8. Unique Identifier : AIDSLINE MED/20375035
- Roos MT; van Lier RA; Hamann D; Knol GJ; Verhoofstad I; van Baarle D; Miedema F; Schellekens PT; Department of Clinical Viro-Immunology, CLB and Laboratory for; Experimental and Clinical Immunology of the University of; Amsterdam at the CLB, Amsterdam, The Netherlands. m_roos@clb.nl
- In response to viral infection, unprimed naive CD8(+), major histocompatibility complex class I-restricted, virus-specific T cells clonally expand and differentiate into memory- and effector-type cells. Changes in CD8(+) subset distribution were studied in 17 subjects with acute human immunodeficiency virus type 1 inf
- Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts.
- J Infect Dis. 2000 Aug;182(2):459-66. Unique Identifier : AIDSLINE MED/20375036
- Anzala AO; Simonsen JN; Kimani J; Ball TB; Nagelkerke NJ; Rutherford J; Ngugi EN; Bwayo JJ; Plummer FA; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.
- In Kenya , the median incubation time to AIDS in seroconverting sex workers is 4 years; this incubation time is specific to female sex workers. We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency viru
- High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus.
- J Infect Dis. 2000 Aug;182(2):467-73. Unique Identifier : AIDSLINE MED/20375037
- Sturm-Ramirez K; Gaye-Diallo A; Eisen G; Mboup S; Kanki PJ; Department of Immunology and Infectious Diseases, Harvard School; of Public Health and Harvard AIDS Institute, Boston,; Massachusetts 02115, USA.
- Bacterial vaginosis (BV) was identified recently as a cofactor that promotes sexual transmission of human immunodeficiency virus (HIV). This study was done to determine if interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha could be measured consistently in cervical secretions and if high levels of these cyto
- Natural T, gammadelta, and NK cells in mycobacterial, Salmonella, and human immunodeficiency virus infections.
- J Infect Dis. 2000 Aug;182(2):474-81. Unique Identifier : AIDSLINE MED/20375038
- Jason J; Buchanan I; Archibald LK; Nwanyanwu OC; Bell M; Green TA; Eick A; Han A; Razsi D; Kazembe PN; Dobbie H; Midathada M; Jarvis WR; Immunology Branch, Division of AIDS, STD, and TB Laboratory; Research, National Center for Infectious Diseases, Atlanta, GA; 30333. JMJ1@CDC.gov.
- NK cells, gammadelta T cell antigen receptor chain-positive cells, and CD3(+)CD16/56(+) (natural T [NT]) cells are involved in innate immunity and immunoregulation; however, their role in clinical infection is not well defined. Cytofluorometric analysis was used to examine peripheral blood from bacteremic, nonbacterem
- Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients.
- J Infect Dis. 2000 Aug;182(2):551-7. Unique Identifier : AIDSLINE MED/20375048
- Kazanjian P; Armstrong W; Hossler PA; Burman W; Richardson J; Lee CH; Crane L; Katz J; Meshnick SR; Division of Infectious Diseases, Dept. of Medicine, University of; Michigan Health System, Ann Arbor, MI 48109-0378, USA.; pkazanji@umich.edu
- This study was conducted to determine whether Pneumocystis carinii dyhydropteroate synthase (DHPS) gene mutations in AIDS patients with P. carinii pneumonia (PCP) are affected by duration of sulfa or sulfone prophylaxis and influence response to sulfa or sulfone therapy. The P. carinii DHPS genes from 97 AIDS patients
- Biological considerations in the development of a human immunodeficiency virus vaccine.
- J Infect Dis. 2000 Aug;182(2):579-89. Unique Identifier : AIDSLINE MED/20375052
- Nathanson N; Mathieson BJ; Office of AIDS Research, National Institutes of Health, Bethesda,; MD 20892-2340, USA. nathansn@od.nih.gov
- Over the last 12 years, many human immunodeficiency virus (HIV) vaccine candidates have been tried in humans, with disappointing results. In particular, recombinant envelope proteins have failed to elicit strong cellular immune responses or neutralizing antibody against many wild-type isolates of HIV-1. Attenuated str
- Increased liver decompensation risk with atypical hepatitis C virus antibody levels.
- J Infect Dis. 2000 Aug;182(2):590-4. Unique Identifier : AIDSLINE MED/20375053
- Goedert JJ; Hatzakis A; Maloney EM; Eyster ME; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852, USA. goedertJ@mail.nih.gov
- Knowledge of serum markers of liver decompensation would facilitate care of patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. HCV load and anti-c33c and anti-NS5 levels did not distinguish 28 HCV- and HIV-positive predecompensation patients from 28 matched control patients, where
- Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients.
- J Infect Dis. 2000 Aug;182(2):599-602. Unique Identifier : AIDSLINE MED/20375055
- Molina JM; Ferchal F; Rancinan C; Raffi F; Rozenbaum W; Sereni D; Morlat P; Journot V; Decazes JM; Chene G; Clinique des Maladies Infectieuses, Hopital Saint-Louis, 1; Avenue Claude Vellefaux, 75475 Paris Cedex 10, France.; molina@chu-stlouis.fr
- The safety and efficacy of a once-daily regimen that combines emtricitabine, didanosine, and efavirenz was studied among 40 previously untreated human immunodeficiency virus (HIV)-infected patients. The median plasma HIV RNA level was 4.77 log(10) copo
- Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease.
- J Infect Dis. 2000 Aug;182(2):603-6. Unique Identifier : AIDSLINE MED/20375056
- Kalish LA; Collier AC; Flanigan TP; Kumar PN; New England Research Institutes, Watertown, MA 02472, USA.; lesk@neri.org
- Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study oo
- A fusion inhibitor (FP-21399) for the treatment of human immunodeficiency virus infection: a phase I study.
- J Infect Dis. 2000 Aug;182(2):607-10. Unique Identifier : AIDSLINE MED/20375057
- Dezube BJ; Dahl TA; Wong TK; Chapman B; Ono M; Yamaguchi N; Gillies SD; Chen LB; Crumpacker CS; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Boston, MA 02215, USA. bdezube@caregroup.harvard.edu
- FP-21399 is a bis(disulfonaphthalene) derivative that prevents human immunodeficiency virus (HIV) infection of uninfected cells by blocking entry of the virus. FP-21399 shows an affinity for lymph nodes. In this phase I study, FP-21399 was administered intravenously over 1 h as a single dose (0.9, 1.7, 2.8, and 4.2 mgo
- Risk for preventable opportunistic infections in persons with AIDS after antiretroviral therapy increases CD4+ T lymphocyte counts above prophylaxis thresholds.
- J Infect Dis. 2000 Aug;182(2):611-5. Unique Identifier : AIDSLINE MED/20375058
- Dworkin MS; Hanson DL; Kaplan JE; Jones JL; Ward JW; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA. mdd3@cdc.gov
- To determine incidence and risk for preventable opportunistic infections (Pneumocystis carinii pneumonia [PCP] and disseminated Mycobacterium avium-complex [MAC] infection) in persons whose CD4(+) T lymphocyte counts had increased by >/=100 cells/&mgr;L to exceed the threshold of risk and in persons whose CD4(+) co
- Tumor necrosis factor-alpha increased production during thalidomide treatment in patients with tuberculosis and human immunodeficiency virus coinfection [letter]
- J Infect Dis. 2000 Aug;182(2):639-40. Unique Identifier : AIDSLINE MED/20375064
- Gori A; Rossi MC; Trabattoni D; Marchetti G; Fusi ML; Molteni C; Clerici M; Franzetti1 F
- B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells.
- J Exp Med. 2000 Sep 4;192(5):637-46. Unique Identifier : AIDSLINE MED/20432252
- Moir S; Malaspina A; Li Y; Chun TW; Lowe T; Adelsberger J; Baseler M; Ehler LA; Liu S; Davey RT Jr; Mican JA; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. smoir@niaid.nih.gov
- The impact of HIV-associated immunopathogenesis on B cells has been largely associated with indirect consequences of viral replication. This study demonstrates that HIV interacts directly with B cells in both lymphoid tissues and peripheral blood. B cells isolated from lymph node and peripheral blood mononuclear cells
- [Infected aneurysm of abdominal aorta: early CT finding]
- J Radiol. 2000 Aug;81(8):899-901. Unique Identifier : AIDSLINE MED/20377703
- Sellami D; Lucidarme O; Lebleu L; Grenier P; Service de radiologie, Universite Pierre-et-Marie-Curie,; Hopital de la Pitie-Salpeltriere, 47, boulevard de; l'Hopital, 75651 Paris Cedex 13.
- Infected abdominal aortic aneurysm is an uncommon but life-threatening disease, especially in case of salmonella infection. Early CT findings should be well known in order to allow immediate diagnosis and accurate management. The authors present an early CT finding of a salmonella infected aneurysm of abdominal aorta
- How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.
- J Mol Biol. 2000 Sep 1;301(5):1207-20. Unique Identifier : AIDSLINE PDB/1F7A
- Prabu-Jeyabalan M; Nalivaika E; Schiffer CA; Department of Pharmacology and Molecular Toxicology, University; of Massachusetts Medical School, Worcester, MA, 01655, USA.
- The crystal structure of an actual HIV-1 protease-substrate complex is presented at 2.0 A resolution (R-value of 19.7 % (R(free) 23.3 %)) between an inactive variant (D25N) of HIV-1 protease and a long substrate peptide, Lys-Ala-Arg-Val-Leu-Ala-Glu-Ala-Met-Ser, which covers a full binding epitope of capsid(CA)-p2, cle
- Burnout in substance abuse counselors. Impact of environment, attitudes, and clients with HIV.
- J Subst Abuse Treat. 2000 Sep;19(2):117-26. Unique Identifier : AIDSLINE MED/20420124
- Shoptaw S; Stein JA; Rawson RA; Matrix Center, 12304 Santa Monica Boulevard, Suite, 90025, Los; Angeles, CA, USA. shoptaw@ix.netcom.com
- Due to associations between acquired immunodeficiency sydnrome (AIDS) and substance abuse, many substance abuse treatment counselors have clients with human immunodeficiency virus (HIV)/AIDS. We assess the contribution of various hypothesized predictors of burnout among 134 substance abuse counselors working with clie
- Effect of the cytoplasmic domain of the simian immunodeficiency virus envelope protein on incorporation of heterologous envelope proteins and sensitivity to neutralization.
- J Virol. 2000 Sep;74(18):8219-25. Unique Identifier : AIDSLINE MED/20411391
- Vzorov AN; Compans RW; Department of Microbiology and Immunology and Emory Vaccine; Center, Emory University School of Medicine, Atlanta, Georgia; 30322, USA.
- In addition to the viral envelope (Env) proteins, host cell-derived proteins have been reported to be present in human immunodeficiency virus and simian immunodeficiency virus (SIV) envelopes, and it has been postulated that they may play a role in infection. We investigated whether the incorporation of host cell prot
- Expression of mouse mammary tumor virus superantigen accelerates tumorigenicity of myeloma cells.
- J Virol. 2000 Sep;74(18):8226-33. Unique Identifier : AIDSLINE MED/20411392
- Umemura M; Wajjwalku W; Upragarin N; Liu T; Nishimura H; Matsuguchi T; Nishiyama Y; Wilson GM; Yoshikai Y; Laboratory of Host Defense, Research Institute for Disease; Mechanism and Control, Nagoya University School of Medicine,; Nagoya 466-8550, Japan.
- To investigate whether superantigen (SAG) from endogenous mouse mammary tumor virus functions as an immunogenic or a tumorigenic factor in tumor development, the BALB/c myeloma cell line FO was transfected with the SAG gene from the 3 Mtv-50 long terminal repeat (LTR) open reading frame (ORF), the product of which wa
- Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process.
- J Virol. 2000 Sep;74(18):8252-61. Unique Identifier : AIDSLINE MED/20411395
- Zhang H; Pomerantz RJ; Dornadula G; Sun Y; Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA. hui.zhang@mail.tju.edu
- Virion infectivity factor (Vif) is a protein encoded by human immunodeficiency virus types 1 and 2 (HIV-1 and -2) and simian immunodeficiency virus, plus other lentiviruses, and is essential for viral replication either in vivo or in culture for nonpermissive cells such as peripheral blood lymphoid cells, macrophages,
- In vivo genomic footprinting of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat enhancer sequences in HTLV-1-infected human T-cell lines with different levels of Tax I activity.
- J Virol. 2000 Sep;74(18):8277-85. Unique Identifier : AIDSLINE MED/20411398
- Datta S; Kothari NH; Fan H; Cancer Research Institute and Department of Molecular Biology and; Biochemistry, University of California, Irvine, California 92697,; USA.
- The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) enhances viral gene expression through sequences in the U3 region of the viral long terminal repeat. These sequences consist of three imperfect 21-bp repeats (TRE-1s) and a region between the promoter-central and promoter-proximal 21-bp repeats (TRE-2). Th
- Direct ex vivo kinetic and phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization.
- J Virol. 2000 Sep;74(18):8286-91. Unique Identifier : AIDSLINE MED/20411399
- Hassett DE; Slifka MK; Zhang J; Whitton JL; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA. dhassett@scripps.edu
- CD8(+) T-cell responses can be induced by DNA immunization, but little is known about the kinetics of these responses in vivo in the absence of restimulation or how soon protective immunity is conferred by a DNA vaccine. It is also unclear if CD8(+) T cells primed by DNA vaccines express the vigorous effector function
- Avian retrovirus DNA internal attachment site requirements for full-site integration in vitro.
- J Virol. 2000 Sep;74(18):8292-8. Unique Identifier : AIDSLINE MED/20411400
- Chiu R; Grandgenett DP; Institute for Molecular Virology, St. Louis University Health; Sciences Center, St. Louis, Missouri 63110, USA.
- Concerted integration of retrovirus DNA termini into the host chromosome in vivo requires specific interactions between the cis-acting attachment (att) sites at the viral termini and the viral integrase (IN) in trans. In this study, reconstruction experiments with purified avian myeloblastosis virus (AMV) IN and retro
- gammadelta(+) T-Lp6phocyte cytotoxicity against envelope-expressing target cells is unique to the alymphocytic state of bovine leukemia virus infection in the natural host.
- J Virol. 2000 Sep;74(18):8299-306. Unique Identifier : AIDSLINE MED/20411401
- Lundberg P; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
- Bovine leukemia virus (BLV) is a complex B-lymphotrophic retrovirus of cattle and the causative agent of enzootic bovine leukosis. Serum antibody in infected animals does not correlate with protection from disease, yet only some animals develop severe disease. While a cytotoxic T-lymphocyte response may be responsible
- Development of minimal lentivirus vectors derived from simian immunodeficiency virus (SIVmac251) and their use for gene transfer into human dendritic cells.
- J Virol. 2000 Sep;74(18):8307-15. Unique Identifier : AIDSLINE MED/20411402
- Mangeot PE; Negre D; Dubois B; Winter AJ; Leissner P; Mehtali M; Kaiserlian D; Cosset FL; Darlix JL; LaboRetro, Unite de Virologie Humaine (INSERM-ENS no. 412),; Lyon, France.
- Lentivirus-derived vectors are very promising gene delivery systems since they are able to transduce nonproliferating differentiated cells, while murine leukemia virus-based vectors can only transduce cycling cells. Here we report the construction and characterization of highly efficient minimal vectors derived from s
- Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity.
- Unique Identifier : AIDSLINE MED/20411403
- Sierra S; Davila M; Lowenstein PR; Domingo E
- Passage of foot-and-mouth disease virus (FMDV) in cell culture in the presence of the mutagenic base analog 5-fluorouracil or 5-azacytidine resulted in decreases of infectivity and occasional extinction of the virus. Low viral loads and low viral fitness
- Sequences in the 5' and 3' R elements of human immunodeficiency virus type 1 critical for efficient reverse transcription.
- J Virol. 2000 Sep;74(18):8324-34. Unique Identifier : AIDSLINE MED/20411404
- Ohi Y; Clever JL; Department of Microbiology, University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78229-3900, USA.
- The genome of human immunodeficiency virus type 1 (HIV-1) contains two direct repeats (R) of 97 nucleotides at each end. These elements are of critical importance during the first-strand transfer of reverse transcription, during which the minus-strand strong-stop DNA (-sssDNA) is transferred from the 5 end to the 3
- CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.
- J Virol. 2000 Sep;74(18):8349-57. Unique Identifier : AIDSLINE MED/20411407
- Neville KL; Dal Canto MC; Bluestone JA; Miller SD; Department of Microbiology-Immunology, Interdepartmental; Immunobiology Center, Northwestern University Medical School,; Chicago, Illinois 60611, USA.
- Theiler s murine encephalomyelitis virus (TMEV) is a natural mouse pathogen which causes a lifelong persistent infection of the central nervous system (CNS) accompanied by T-cell-mediated myelin destruction leading to chronic, progressive hind limb paralysis. TMEV-induced demyelinating disease (TMEV-IDD) is considered
- Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120.
- J Virol. 2000 Sep;74(18):8358-67. Unique Identifier : AIDSLINE MED/20411408
- Derdeyn CA; Decker JM; Sfakianos JN; Wu X; O'Brien WA; Ratner L; Kappes JC; Shaw GM; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama 35294, USA.
- T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion active state following interactions of the surface glycoprotein, gp120, with CD4 and coreceptor molecules displayed on the target cell
- Specific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection.
- J Virol. 2000 Sep;74(18):8376-81. Unique Identifier : AIDSLINE MED/20411410
- Lidbury BA; Mahalingam S; Gadi Research Centre, Division of Science and Design, University; of Canberra, Canberra, ACT 2601, Australia.; Lidbury@scides.canberra.edu.au
- Ross River virus (RRV) is an indigenous Australian arthropod-borne alphavirus responsible for epidemic polyarthritis (EPA), myalgia, and lethargy in humans. Macrophages and monocytes have been associated with human RRV disease, and previous studies have shown that RRV is capable of infecting macrophages via both a nat
- Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.
- J Virol. 2000 Sep;74(18):8390-401. Unique Identifier : AIDSLINE MED/20411412
- Archer RH; Dykes C; Gerondelis P; Lloyd A; Fay P; Reichman RC; Bambara RA; Demeter LM; Department of Medicine, University of Rochester School of; Medicine and Dentistry, Rochester, New York 14642, USA.
- Three mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (V106A, V179D, and Y181C), which occur in clinical isolates and confer resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs), were analyzed for RNA- and DNA-dependent DNA polymerization and RNase H cleavage. All mutants
- Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.
- J Virol. 2000 Sep;74(18):8413-24. Unique Identifier : AIDSLINE MED/20411414
- Kaur A; Hale CL; Ramanujan S; Jain RK; Johnson RP; Division of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, Massachusetts; 01772, USA. amitinder_kaur@hms.harvard.edu
- Although lymphocyte turnover in chronic human immunodeficiency virus and simian immunodeficiency virus (SIV) infection has been extensively studied, there is little information on turnover in acute infection. We carried out a prospective kinetic analysis of lymphocyte proliferation in 13 rhesus macaques inoculated wit
- Analysis of Mason-Pfizer monkey virus Gag domains required for capsid assembly in bacteria: role of the N-terminal proline residue of CA in directing particle shape.
- J Virol. 2000 Sep;74(18):8452-9. Unique Identifier : AIDSLINE MED/20411418
- Rumlova-Klikova M; Hunter E; Nermut MV; Pichova I; Ruml T; Department of Biochemistry, Institute of Organic Chemistry and; Biochemistry, Academy of Sciences, 166 10 Prague, Czech Republic.
- Mason- Pfizer monkey virus (M-PMV) preassembles immature capsids in the cytoplasm prior to transporting them to the plasma membrane. Expression of the M-PMV Gag precursor in bacteria results in the assembly of capsids indistinguishable from those assembled in mammalian cell
- Efficient cell infection by Moloney murine leukemia virus-derived particles requires minimal amounts of envelope glycoprotein.
- J Virol. 2000 Sep;74(18):8480-6. Unique Identifier : AIDSLINE MED/20411421
- Bachrach E; Marin M; Pelegrin M; Karavanas G; Piechaczyk M; Institut de Genetique Moleculaire, UMR 5535/IFR24, CNRS, BP; 5051, 34293 Montpellier Cedex 05, France.
- Retrovirus entry into cells is mediated by specific interactions between the retrovirally encoded Env envelope glycoprotein and a host cell surface receptor. Though a number of peptide motifs responsible for the structure as well as for the binding and fusion activities of Env have been identified, only a few quantita
- Patterns of changes in human immunodeficiency virus type 1 V3 sequence populations late in infection.
- J Virol. 2000 Sep;74(18):8494-501. Unique Identifier : AIDSLINE GENBANK/AF155906
- Nelson JA; Baribaud F; Edwards T; Swanstrom R; UNC Center for AIDS Research, University of North Carolina at; Chapel Hill, Chapel Hill, North Carolina 27599, USA.
- We have used a V3-specific heteroduplex tracking assay (V3-HTA) with probes from two different human immunodeficiency virus type 1 (HIV-1) subtypes to examine the extent and pace of HIV-1 evolution late in infection. Twenty-four subjects with advanced HIV-1 infection (CD4(+) T-cell count,
- Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug.
- J Virol. 2000 Sep;74(18):8524-31. Unique Identifier : AIDSLINE MED/20411426
- Mammano F; Trouplin V; Zennou V; Clavel F; Laboratoire de Recherche Antivirale, INSERM U82, Paris, France.; mammano@bichat.inserm.fr
- Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) is a major obstacle to the full success of combined antiretroviral therapy. High-level resistance to these compounds is the consequence of stepwise accumulation of amino acid substitu
- Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.
- J Virol. 2000 Sep;74(18):8532-40. Unique Identifier : AIDSLINE MED/20411427
- Schwam DR; Luciano RL; Mahajan SS; Wong L; Wilson AC; Department of Microbiology and Kaplan Comprehensive Cancer; Center, New York University School of Medicine, New York, New; York 10016, USA.
- Human herpesvirus 8 (HHV-8; also known as Kaposi s sarcoma-associated herpesvirus) is the causative agent of Kaposi s sarcoma and certain B-cell lymphomas. In most infected cells, HHV-8 establishes a latent infection characterized by the expression of latency-associated nuclear antigen (LANA) encoded by open reading f
- Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
- J Virol. 2000 Sep;74(18):8541-9. Unique Identifier : AIDSLINE MED/20411428
- Altfeld MA; Trocha A; Eldridge RL; Rosenberg ES; Phillips MN; Addo MM; Sekaly RP; Kalams SA; Burchett SA; McIntosh K; Walker BD; Goulder PJ; Partners AIDS Research Center and Infectious Disease Unit,; Massachusetts General Hospital and Harvard Medical School,; Boston, USA.
- Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte (CTL) responses play a major role in the antiviral immune response, but the relative contribution of CTL responses restricted by different HLA class I molecules is less well defined. HLA-B60 or the related allele B61 is expressed in 10 to 20%
- CD4-Negative cells bind human immunodeficiency virus type 1 and efficiently transfer virus to T cells.
- J Virol. 2000 Sep;74(18):8550-7. Unique Identifier : AIDSLINE MED/20411429
- Olinger GG; Saifuddin M; Spear GT; Department of Immunology/Microbiology, Rush University, Chicago,; Illinois 60612, USA.
- The ability of human immunodeficiency virus strain MN (HIV(MN)), a T-cell line-adapted strain of HIV, and X4 and R5 primary isolates to bind to various cell types was investigated. In general, HIV(MN) bound to cells at higher levels than did the primary isolates. Virus bound to both CD4-positive (CD4(+)) and CD4-negat
- Study of full-length porcine endogenous retrovirus genomes with envelope gene polymorphism in a specific-pathogen-free Large White swine herd.
- J Virol. 2000 Sep;74(18):8575-81. Unique Identifier : AIDSLINE GENBANK/AJ288592
- Bosch S; Arnauld C; Jestin A; Zoopole Developement, Rond Point du Zoopole, France.
- Specific-pathogen-free (SPF) swine appear to be the most appropriate candidate for pig to human xenotransplantation. Still, the risk of endogenous retrovirus transmission represents a major obstacle, since two human-tropic porcine endogenous retroviruses (PERVs) had been characterized in vitro (P. Le Tissier, J. P. St
- Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene.
- J Virol. 2000 Sep;74(18):8623-34. Unique Identifier : AIDSLINE GENBANK/AF145701
- Chen J; Ueda K; Sakakibara S; Okuno T; Yamanishi K; Department of Microbiology, Osaka University Medical School,; Osaka 565-0871, Japan.
- The Kaposi s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, open reading frame (ORF) K9 encodes a viral interferon regulatory factor (vIRF) that functions as a repressor for interferon-mediated signal transduction. Consequently, this gene is thought to play an important role in the tumorigenicity of KS
- Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imaging.
- Unique Identifier : AIDSLINE MED/20411441
- Hermida-Matsumoto L; Resh MD
- Budding of lentiviruses occurs at the plasma membrane, but the preceding steps involved in particle assembly are poorly understood. Since the Gag polyprotein mediates virion assembly and budding, studies on the localization of Gag within the cell should provide insight into the mechanism of particle assembly. Here, we
- Membrane targeting properties of a herpesvirus tegument protein-retrovirus Gag chimera.
- J Virol. 2000 Sep;74(18):8692-9. Unique Identifier : AIDSLINE MED/20411443
- Bowzard JB; Visalli RJ; Wilson CB; Loomis JS; Callahan EM; Courtney RJ; Wills JW; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.
- The retroviral Gag protein is capable of directing the production and release of virus-like particles in the absence of all other viral components. Budding normally occurs after Gag is transported to the plasma membrane by its membrane-targeting and binding (M) domain. In the Rous sarcoma virus (RSV) Gag protein, the
- Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.
- J Virol. 2000 Sep;74(18):8726-31. Unique Identifier : AIDSLINE MED/20411447
- Gobbi A; Stoddart CA; Locatelli G; Santoro F; Bare C; Linquist-Stepps V; Moreno ME; Abbey NW; Herndier BG; Malnati MS; McCune JM; Lusso P; Unit of Human Virology, Department of Biological and; Technological Research, San Raffaele Scientific Institute, 20132; Milan, Italy.
- Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicat
- Human immunodeficiency virus type 1 envelope epitope-specific CD4(+) T lymphocytes in simian/human immunodeficiency virus-infected and vaccinated rhesus monkeys detected using a peptide-major histocompatibility complex class II tetramer.
- J Virol. 2000 Sep;74(18):8751-6. Unique Identifier : AIDSLINE MED/20411451
- Kuroda MJ; Schmitz JE; Lekutis C; Nickerson CE; Lifton MA; Franchini G; Harouse JM; Cheng-Mayer C; Letvin NL; Division of Viral Pathogenesis, Department of Medicine, Beth; Israel Deaconess Medical Center, Harvard Medical School, Boston,; Massachusetts 02215, USA. mkuroda@caregroup.harvard.edu
- A tetrameric recombinant major histocompatibility complex (MHC) class II-peptide complex was used to quantitate human immunodeficiency virus type 1 (HIV-1) envelope (Env)-specific CD4(+) T cells in vaccinated and in simian/human immunodeficiency virus (SHIV)-infected rhesus monkeys. A rhesus monkey MHC class II DR mol
- Induction of mucosal homing virus-specific CD8(+) T lymphocytes by attenuated simian immunodeficiency virus.
- J Virol. 2000 Sep;74(18):8762-6. Unique Identifier : AIDSLINE MED/20411453
- Cromwell MA; Veazey RS; Altman JD; Mansfield KG; Glickman R; Allen TM; Watkins DI; Lackner AA; Johnson RP; Divisions of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, Massachusetts; 01772, USA.
- Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8(+) lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency vir
- The B-oligomer of pertussis toxin inhibits human immunodeficiency virus type 1 replication at multiple stages.
- J Virol. 2000 Sep;74(18):8767-70. Unique Identifier : AIDSLINE MED/20411454
- Alfano M; Pushkarsky T; Poli G; Bukrinsky M; The Picower Institute for Medical Research, Manhasset, New York; 11030, USA.
- We have recently demonstrated that the bi