Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes.

Folia Histochem Cytobiol. 2000;38(1):21-3. Unique Identifier : AIDSLINE MED/20226330
Jagodzinski PP; Trzeciak WH; Department of Physiological Chemistry, University of Medical; Sciences, Poznan, Poland. pjagodzi@eucalyptus.usoms.poznan.pl

Abstract: Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 cells than on the Th1, which might explain better replication of HIV-1 viruses in the Th2 cells.

Keywords: JOURNAL ARTICLE Antibodies Antigens, Surface/ANALYSIS/IMMUNOLOGY CD4 Lymphocyte Count/*METHODS Flow Cytometry Human HIV Infections/IMMUNOLOGY HIV-1 Receptors, CXCR4/*ANALYSIS/IMMUNOLOGY Support, Non-U.S. Gov't Th1 Cells/CHEMISTRY/*CYTOLOGY/VIROLOGY Th2 Cells/CHEMISTRY/*CYTOLOGY/VIROLOGY

KWDjournalarticleantibodiesantigens,surface/analysis/immunologycd4lymphocytecount/KWDmethodsflowcytometryhumanhivinfections/immunologyhiv-1receptors,cxcr4/KWDanalysis/immunologysupport,non-uKWDsKWDgov'tth1cells/chemistry/KWDcytology/virologyth2cells/chemistry/KWDcytology/virology
000830
A0080977

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