A pneumococcal capsular polysaccharide vaccine induces a repertoire shift with increased VH3 expression in peripheral B cells from human immunodeficiency virus (HIV)-uninfected but not HIV-infected persons.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

J Infect Dis. 2000 Apr;181(4):1313-21. Unique Identifier : AIDSLINE MED/20227753
Chang Q; Abadi J; Alpert P; Pirofski L; Departments of Microbiology and Immunology, Division of; Infectious Diseases, and Montefiore Hospital and Medical Center,; Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract: The molecular mechanism of pneumococcal vaccine failure in human immunodeficiency virus (HIV)-infected persons is not fully understood. A polymerase chain reaction ELISA was used to determine the proportion of peripheral IgG, IgA, and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (VH) subgroups before and 7 days after pneumococcal vaccination of 12 HIV-infected and 12 HIV-uninfected subjects. Significant postvaccination increases in the expression of the VH3 subgroup by IgG and IgA and a greater serologic response to vaccination were observed in the HIV-uninfected group. In contrast, the HIV-infected group had reduced prevaccination IgG VH3 and a postvaccination increase in IgG VH5. These results demonstrate that pneumococcal vaccination changes the pattern of B cell VH gene expression and support the concept that aberrant VH3 expression may translate into a poor antipneumococcal response in the setting of HIV infection.

Keywords: JOURNAL ARTICLE Adult Antibodies, Bacterial/BIOSYNTHESIS AIDS-Related Opportunistic Infections/PREVENTION & CONTROL B-Lymphocytes/*IMMUNOLOGY Bacterial Vaccines/*IMMUNOLOGY Enzyme-Linked Immunosorbent Assay Female Human HIV Infections/*IMMUNOLOGY IgA/BIOSYNTHESIS IgG/BIOSYNTHESIS IgM/BIOSYNTHESIS Immunoglobulin Variable Region/*BIOSYNTHESIS/GENETICS Immunoglobulins, Heavy-Chain/*BIOSYNTHESIS/GENETICS Male Middle Age Polymerase Chain Reaction Streptococcus pneumoniae/*IMMUNOLOGY Support, U.S. Gov't, P.H.S.

000830
A0080952

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