Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort Study. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort Study.

J Infect Dis. 2000 Apr;181(4):1475-8. Unique Identifier : AIDSLINE MED/20227777
Hisada M; O'Brien TR; Rosenberg PS; Goedert JJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, MD 20852, USA.; mh280i@nih.gov

Abstract: A high human immunodeficiency virus (HIV) load may increase the probability of HIV transmission by sexual contact, but the association of virus load of hepatitis C virus (HCV) with risk of HCV transmission is uncertain. HIV and HCV virus loads were examined in hemophilic men, as were risks of HIV and HCV transmission to their female partners in a hemophilia cohort in which most subjects are dually infected. A higher HIV load was associated with an increased risk of HIV transmission (odds ratio [OR], 1.31 per log10 increase in virus load). A higher HCV load was associated, although not significantly, with an increased risk of HCV transmission (OR, 1. 42 per log10). HCV load was higher among dually infected men than in those infected with HCV alone (P=.001). However, much larger studies are needed to clearly show whether HIV/HCV coinfection significantly increases the risk of HCV transmission to female partners.

Keywords: JOURNAL ARTICLE Adult Disease Transmission, Horizontal/STATISTICS & NUMER DATA Female Hemophilia A/*COMPLICATIONS Hepatitis C/*TRANSMISSION *Hepatitis C-Like Viruses *Heterosexuality Human *HIV HIV Infections/*TRANSMISSION Male Risk Factors RNA, Viral/ANALYSIS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. *Viral Load

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000830
A0080947

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