2000
- HIV-1 infects and alters immune function of a monocyte subset expressing low CD14 surface phenotype.
- Viral Immunol. 2000;13(1):19-26. Unique Identifier : AIDSLINE MED/20195303
- Hardegen NJ; Toro LA; Muller J; Wahl LM; Hewlett IK; Dhawan S; Immunopathology Section, National Institute of Dental and; Craniofacial Research, National Institutes of Health, Bethesda,; MD, USA.
- Monocytes represent a leukocyte subset that express high levels of CD14 on their surface (CD14-high). These cells play a critical role in the pathogenesis of HIV-1 infection. In the present study, we have identified a monocyte subset expressing an extremely low level of CD14 (CD14-low), and examined their susceptibili
- HIV-DNA vaccination following transfer of a large number of activated T cells enhances immunoresponses against HIV-1.
- Viral Immunol. 2000;13(1):3-8. Unique Identifier : AIDSLINE MED/20195301
- Hamajima K; Xin KQ; Fukushima J; Yang J; Honsho A; Nakazawa M; Yanoma S; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, Japan.
- HIV gp120 plus specific peptides are recognized in a similar manner to specific HLA plus peptide by HLA-restricted antigen-specific T-cell lines.
- Viral Immunol. 2000;13(1):9-17. Unique Identifier : AIDSLINE MED/20195302
- Sheikh J; Souberbielle B; Westby M; Austen B; Dalgleish AG; Division of Surgery, St. George's Hospital Medical School,; Tooting, London, UK.
- HIV induces disease only following chronic activation of the immune system. Other retroviruses such as the mouse mammary tumour virus (MMTV) activate a large percentage of T cells by encoding a superantigen (SAg). To date there is no evidence that HIV encodes a SAg. An alternative way to induce pan-activation of the i
- Ethnic and racial differences in long-term survival from hospitalization for HIV infection.
- J Health Care Poor Underserved. 2000 May;11(2):163-78. Unique Identifier : AIDSLINE MED/20253983
- Cunningham WE; Mosen DM; Morales LS; Andersen RM; Shapiro MF; Hays RD; Department of Health Services, School of Public Health,; University of California, Los Angeles 90095, USA.
- This prospective cohort study compares 200 hospitalized, HIV-infected patients (Hispanic, African American, and white) from May 1992 to October 1998 to assess mortality (versus survival) over 75 months of follow-up. The relative risk of six-year mortality for each ethnic group is compared using Cox proportional hazard
- Diffuse toxoplasmic retinochoroiditis as the initial manifestation of acquired immunodeficiency syndrome.
- J Formos Med Assoc. 2000 Mar;99(3):219-23. Unique Identifier : AIDSLINE MED/20280589
- Lee YF; Chen SJ; Chung YM; Liu JH; Wong WW; Department of Ophthalmology, Taipei Veterans General Hospital,; National Yang-Ming University, School of Medicine, Taiwan.
- Toxoplasmic retinochoroiditis is an important opportunistic retinal infection in human immunodeficiency virus (HIV)-infected patients. It may present as diffuse necrotizing retinochoroiditis instead of a focal lesion and may be the initial manifestation of HIV infection. A 50-year-old heterosexual man presented with b
- South Africa to tighten control on drug trials after five death [news]
- BMJ. 2000 Apr 15;320(7241):1028. Unique Identifier : AIDSLINE MED/20227657
- Sidley P
- AIDS patients in South Africa to get free drug [news]
- BMJ. 2000 Apr 22;320(7242):1095. Unique Identifier : AIDSLINE MED/20237349
- Sidley P
- Unlike GMC, GP did not follow line of political correctness [letter; comment]
- BMJ. 2000 Apr 22;320(7242):1148. Unique Identifier : AIDSLINE MED/20237380
- Newmark J
- [Hepatitis C: viral load and plasma lipids (letter)]
- Gastroenterol Hepatol. 2000 Mar;23(3):149. Unique Identifier : AIDSLINE MED/20264816
- Escolar JL; Gavilan JC; Rivera A; Clavijo E
- Therapeutic implications of recent data on immune pathogenesis of HIV disease [editorial]
- AIDS Patient Care STDS. 1999 Aug;13(8):449-51. Unique Identifier : AIDSLINE MED/20260316
- Laurence J
- Surviving the fall: an AIDS caregiver's journey.
- AIDS Patient Care STDS. 1999 Aug;13(8):453-7. Unique Identifier : AIDSLINE MED/20260317
- Selwyn PA; Department of Family Medicine, Albert Einstein College of; Medicine, Bronx, New York, USA. selwyn@aecom.yu.edu
- Kala-azar as an AIDS-related opportunistic infection.
- AIDS Patient Care STDS. 1999 Aug;13(8):459-65. Unique Identifier : AIDSLINE MED/20260318
- Murray HW; Department of Medicine, Cornell University Medical College, New; York, New York, USA.
- Visceral leishmaniasis (kala-azar) is a worldwide disseminated protozoal infection primarily transmitted by sand flies. Because host defense against this intracellular infection is T-cell-dependent, kala-azar has predictably joined the list of AIDS-related opportunistic infections in endemic areas. The vast majority o
- Rifabutin prophylaxis against Mycobacterium avium complex infections in HIV-infected patients: impact on the incidence of campylobacteriosis.
- AIDS Patient Care STDS. 1999 Aug;13(8):467-72. Unique Identifier : AIDSLINE MED/20260319
- Pulik M; Genet P; Leturdu F; Lionnet F; Louvel D; Touahri T; Department of Hematology, Victor Dupouy Hospital, Argenteuil,; France.
- Following the observation of the decreasing occurrence of campylobacteriosis in HIV-infected patients. This study examines the incidence of campylobacteriosis in patients who had received rifabutin prophylaxis against Mycobacterium avium complex (MAC) infection compared with the incidence observed among patients treat
- Clinician judgement as a tool for targeting HIV counseling and testing in North Carolina state mental hospitals, 1994.
- AIDS Patient Care STDS. 1999 Aug;13(8):473-9. Unique Identifier : AIDSLINE MED/20260320
- Kirkland KB; Meriwether RA; MacKenzie WR; Binz WC; Allen RJ; Veenhuis PE; Department of Environment, Health and Natural Resources, Raleigh,; North Carolina, USA.
- HIV infection increasingly affects populations that may not appear at high risk based on the use of some traditional targeting strategies. To shed some light on how to more sensitively/effectively identify people who need routine HIV testing and counseling, the objective of this study is to determine the prevalence of
- Home away from home: essential elements in developing housing options for people living with HIV/AIDS.
- AIDS Patient Care STDS. 1999 Aug;13(8):481-91. Unique Identifier : AIDSLINE MED/20260321
- Stajduhar KI; Lindsey E; School of Nursing, University of British Columbia, Vancouver.; magenta@bc.sympatico.ca
- There is a paucity of data to enlighten our understanding regarding the need for a respite care/supported living home for people living with HIV/AIDS (PLWHIV/AIDS) and to identify the essential elements required to initiate this endeavor. Participatory action research was used in this study as the process by which the
- Use of stage of change (SOC) to develop an STD/HIV behavioral intervention: phase 1. A system to classify SOC for STD/HIV sexual risk behaviors--development and reliability in an STD clinic.
- AIDS Patient Care STDS. 1999 Aug;13(8):493-502. Unique Identifier : AIDSLINE MED/20260322
- Coury-Doniger P; Levenkron JC; Knox KL; Cowell S; Urban MA; Department of Medicine, University of Rochester School of; Medicine and Dentistry, New York, USA.
- This paper reports on the initial phase in the development, program implementation, and inter-rater reliability of an application of Stage of Change (SOC) behavioral theory for use in STD/HIV risk reduction. SOC was adapted to assess readiness for sexual behavior change in an urban STD clinic in Rochester, New York. A
- College educated most likely to get PIs [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):503. Unique Identifier : AIDSLINE MED/20260323
- AZT incorporates into leukocyte DNA [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):504. Unique Identifier : AIDSLINE MED/20260325
- Efavirenz approved in Europe [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):504. Unique Identifier : AIDSLINE MED/20260324
- Nevirapine and methadone withdrawal [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):504. Unique Identifier : AIDSLINE MED/20260326
- Treatment of vaginal infections [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):505. Unique Identifier : AIDSLINE MED/20260327
- Stress and lack of social support hastens HIV disease: most compelling evidence to date [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):507-8. Unique Identifier : AIDSLINE MED/20260333
- Makulowich GS
- HIV in prison; HIV and killer T cells [editorial]
- AIDS Patient Care STDS. 2000 Mar;14(3):105-7. Unique Identifier : AIDSLINE MED/20226748
- Laurence J
- HIV in China: an opportunity to halt an emerging epidemic.
- AIDS Patient Care STDS. 2000 Mar;14(3):109-12. Unique Identifier : AIDSLINE MED/20226749
- Ammann AJ; Center for AIDS Prevention, University of California Medical; Center, San Francisco, USA.
- HIV risk and healthcare attitudes among detained adolescents in rural Alabama.
- AIDS Patient Care STDS. 2000 Mar;14(3):113-24. Unique Identifier : AIDSLINE MED/20226750
- Lichtenstein B; University of Alabama at Birmingham, USA.; blichten@sbs.sbs.uab.edu
- This qualitative study explored the dynamics of adolescent HIV risk through focus group interviews of male and female adolescents at an Alabama juvenile detention facility, key informant interviews, and through interviews of HIV-positive and negative adults in institutional settings and public health clinics in Alabam
- Antenatal screening for HIV infection.
- AIDS Patient Care STDS. 2000 Mar;14(3):125-31. Unique Identifier : AIDSLINE MED/20226751
- Gibb DM; Medical Research Council Clinical Trials Unit, Mortimer Market; Center, UCLMS, London, United Kingdom. D.Gibb@ctu.mrc.ac.uk
- Cystic lymphoepithelial lesions of the parotid gland in HIV-1 infection.
- AIDS Patient Care STDS. 2000 Mar;14(3):143-7. Unique Identifier : AIDSLINE MED/20226753
- Uccini S; D'Offizi G; Angelici A; Prozzo A; Riva E; Antonelli G; Baroni CD; Ruco LP; Department of Experimental Medicine, University La Sapienza,; Rome, Italy. s_uccini@uniromal.it
- The benign cystic lymphoepithelial lesion (BLL) of the parotid gland is a rare disorder affecting HIV-1-infected patients. Here we describe the clinical and histopathological features of 10 cases of BLL, who presented to our observation between November 1992 and December 1996, before the combination antiretroviral the
- Disseminated histoplasmosis and AIDS: clinical aspects and diagnostic methods for early detection.
- AIDS Patient Care STDS. 2000 Mar;14(3):149-54. Unique Identifier : AIDSLINE MED/20226754
- Corti ME; Cendoya CA; Soto I; Esquivel P; Trione N; Villafane MF; Corbera KM; Helou S; Negroni R; Unit 10 and Micology Center, F.J. Muniz Infectious Diseases; Hospital, Buenos Aires, Argentina. marcelocorti@cuidad.com.ar
- Disseminated histoplasmosis in AIDS patients is the focus of this paper. Cutaneous lesions are reported as a frequent clinical sign. Bone marrow aspiration and biopsy, blood cultures (lysis-centrifugation technique), bronchoalveolar lavage, and skin lesion scrapings are the most effective diagnostic methods. The ident
- Barriers to and facilitators of HIV-positive patients' adherence to antiretroviral treatment regimens.
- AIDS Patient Care STDS. 2000 Mar;14(3):155-68. Unique Identifier : AIDSLINE MED/20226755
- Roberts KJ; University of California, Los Angeles, USA. kjrobert@ucla.edu
- HIV-positive patients must strictly adhere to antiretroviral regimens for the medications to work properly. Little, however, is known about the obstacles that patients face in adhering to the regimens or what, if anything, helps patients to adhere. The goals of the project were to describe, from HIV-positive patients
- New combination studied [news]
- AIDS Patient Care STDS. 2000 Mar;14(3):169-70. Unique Identifier : AIDSLINE MED/20226756
- OIs despite HAART [news]
- AIDS Patient Care STDS. 2000 Mar;14(3):170. Unique Identifier : AIDSLINE MED/20226757
- Expansion of CD60 helper lymphocytes detected in peripheral lymphocytes of HIV-1 infected individuals is not paralleled in lymph nodes.
- Eur J Med Res. 2000 Apr 19;5(4):150-6. Unique Identifier : AIDSLINE MED/20262165
- Bogner JR; Gruber R; Steckmeier B; Goebel F; Rieber EP; Med. Poliklinik, Pettenkoferstr. 8a, D-80336 Munich, Germany.; jobogner@pk-i.med.uni-muenchen.de
- BACKGROUND AND OBJECTIVE: A significant expansion of CD8 cells with capability of Th2 type helper function had been observed in hemophiliacs with HIV infection. These cells were characterised by the surface co-expression of CD8 and CD60 antigen. Our objective was to investigate this lymphocyte subset in relation to ot
- Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.
- ABOLISM Viral Proteins/GENETICS/*PHARMACOLOGY Clin Cancer Res. 2000 Mar;6(3):1180-9. Unique Identifier : AIDSLINE MED/20203794
- Hideshima T; Chauhan D; Teoh G; Raje N; Treon SP; Tai YT; Shima Y; Anderson KC; Department of Adult Oncology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.
- Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
- Clin Cancer Res. 2000 Mar;6(3):987-93. Unique Identifier : AIDSLINE MED/20203769
- Rha SY; Izbicka E; Lawrence R; Davidson K; Sun D; Moyer MP; Roodman GD; Hurley L; Von Hoff D; Cancer Therapy & Research Center, Institute for Drug Development,; The University of Texas Health Science Center at San Antonio,; 78229, USA. srha@saci.org
- Shortening of telomeres along with an up-regulation of telomerase is implicated in the immortality of tumor cells. Targeting either telomeres or telomerase with specific compounds has been proposed as an anticancer strategy. Because telomerase activity and telomeres are found in normal cells, telomere or telomerase ta
- Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species.
- Clin Chem. 2000 May;46(5):631-5. Unique Identifier : AIDSLINE MED/20256813
- Loeffler J; Hagmeyer L; Hebart H; Henke N; Schumacher U; Einsele H; Medizinische Klinik, Abteilung II, Otfried-Mueller-Strasse 10,; 72076 Tuebingen, Germany. Fax 49-7071-293179, USA.; juergen.loeffler@med.uni-tuebingen.de
- BACKGROUND: The LightCycler(TM) combines rapid amplification of nucleic acids in glass capillaries with melting curve analysis based on fluorescence resonance energy transfer for the sensitive detection of point mutations in various settings, such as drug resistance and hereditary diseases. Point mutations leading to
- Efavirenz interference in estradiol ELISA assay [letter]
- Clin Chem. 2000 May;46(5):734-5. Unique Identifier : AIDSLINE MED/20256835
- Sinicco A; Raiteri R; Rossati A; Savarino A; Di Perri G
- KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT.
- Unique Identifier : AIDSLINE MED/20245901
- Panoskaltsis-Mortari A; Ingbar DH; Jung P; Haddad IY; Bitterman PB; Wangensteen OD; Farrell CL; Lacey DL; Blazar BR
- We investigated keratinocyte growth factor (KGF) as a pretreatment therapy for idiopathic pneumonia syndrome (IPS) generated as a result of lung damage and allogeneic T cell-dependent inflammatory events occurring in the early peri-bone marrow (BM) transplant (BMT) period. B10.BR (H2(k)) recipient mice were transplant
- MAP kinase pathways activated by stress: the p38 MAPK pathway.
- Crit Care Med. 2000 Apr;28(4 Suppl):N67-77. Unique Identifier : AIDSLINE MED/20265598
- Obata T; Brown GE; Yaffe MB; Department of Medicine, Beth Israel Deaconess Medical Center,; Boston, MA, USA.
- A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase (p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and certain mitogens, trigger a stress-regulate
- Optimization of whole blood antigen-specific cytokine assays for CD4(+) T cells.
- Cytometry. 2000 May 1;40(1):60-8. Unique Identifier : AIDSLINE MED/20218907
- Nomura LE; Walker JM; Maecker HT; Biological Research and Development, BD Biosciences,; Immunocytometry Systems, San Jose, CA 95131, USA.
- BACKGROUND: The analysis of cytokine production is a valuable component of studies of immune response to stimulation such as pathogens, vaccines, and other immunological challenges. One highly sensitive method of cytokine evaluation involves three-color flow cytometric analysis of cytokine production in individual CD4
- Importance of the CD3 marker for evaluating changes in rhesus macaque CD4/CD8 T-cell ratios.
- Cytometry. 2000 May 1;40(1):69-75. Unique Identifier : AIDSLINE MED/20218908
- Dykhuizen M; Ceman J; Mitchen J; Zayas M; MacDougall A; Helgeland J; Rakasz E; Pauza CD; Wisconsin Regional Primate Research Center, Madison, WI 53706,; USA.
- BACKGROUND: Until recently, there were no CD3 antibodies that crossreacted with rhesus macaque T cells. Consequently, studies relying on CD8 counts or CD4/CD8 ratios enumerated this subpopulation on the basis of CD8+ or CD8bright+ staining. We used a rhesus-specific, anti-CD3 antibody to better define the CD8+ T-cell
- Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes.
- Folia Histochem Cytobiol. 2000;38(1):21-3. Unique Identifier : AIDSLINE MED/20226330
- Jagodzinski PP; Trzeciak WH; Department of Physiological Chemistry, University of Medical; Sciences, Poznan, Poland. pjagodzi@eucalyptus.usoms.poznan.pl
- Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals an
- Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-alpha gene.
- FASEB J. 2000 May;14(7):1023-31. Unique Identifier : AIDSLINE MED/20245485
- Iida R; Saito K; Yamada K; Basile AS; Sekikawa K; Takemura M; Fujii H; Wada H; Seishima M; Nabeshima T; Department of Neuropsychopharmacology and Hospital Pharmacy,; Nagoya University Graduate School of Medicine, Nagoya 466-8560,; Japan.
- Brain levels of TNF-alpha increase in many inflammatory conditions, including HIV-1 infection, and may contribute to neurodegenerative processes. The paucity of agents that can selectively and potently block TNF-alpha processing or its receptors has led us to investigate the role of TNF-alpha in chronic neurodegenerat
- IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis.
- FASEB J. 2000 May;14(7):948-54. Unique Identifier : AIDSLINE MED/20245476
- Metwali A; Blum AM; Li J; Elliott DE; Weinstock JV; Division of Gastroenterology-Hepatology, Department of Internal; Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
- In murine schistosomiasis, granuloma T cells express VPAC2 mRNA, whereas there is none in splenocytes. This suggests that T cell VPAC2 mRNA is inducible. To address this issue, splenocytes from schistosome-infected mice were incubated with anti-CD3 to induce VPAC2 mRNA, which only appeared when cell cultures also cont
- Cryptosporidium and isospora belli diarrhoea in immunocompromised hosts.
- Indian J Cancer. 1999 Mar;36(1):38-42. Unique Identifier : AIDSLINE MED/20270850
- Ballal M; Prabhu T; Chandran A; Shivananda PG; Department of Microbiology, Kasturba Medical College, Manipal,; Karnataka, India.
- Cryptosporidium and isospora, two of the intestinal coccidian parasites known to be the causative agents of acute diarrhoea in animals, have now emerged as one of the main causes of prolonged life threatening diarrhoea in immunocompromised patients particularly so in patients with AIDS. Between June 1996 and December
- Interaction of merosin (laminin 2) with very late activation antigen-6 is necessary for the survival of CD4+ CD8+ immature thymocytes.
- Immunology. 2000 Apr;99(4):481-8. Unique Identifier : AIDSLINE MED/20253142
- Iwao M; Fukada S; Harada T; Tsujikawa K; Yagita H; Hiramine C; Miyagoe Y; Takeda S; Yamamoto H; Department of Immunology, Graduate School of Pharmaceutical; Sciences, Osaka University, Suita, Osaka, Japan.
- The laminin alpha2-chain is a component of merosin, a member of the laminin family molecules, which is mainly expressed in the basement membranes of striated muscle. It is known that laminin alpha2 gene (lama2) null mutant mice (dy3k/dy3k) exhibit congenital muscular dystrophy (CMD). Because the laminin alpha2-chain i
- Up-regulation of beta-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates.
- Immunology. 2000 Apr;99(4):569-77. Unique Identifier : AIDSLINE MED/20253153
- Lehner T; Wang Y; Cranage M; Tao L; Mitchell E; Bravery C; Doyle C; Pratt K; Hall G; Dennis M; Villinger L; Bergmeier L; Department of Immunobiology, Guy's, King's and St. Thomas'; Hospitals, Medical and Dental Schools, London, UK.
- A non-cognate mechanism of protection against human immunodeficiency virus-1 (HIV-1) infection involves up-regulation of beta-chemokines, which bind and may down-modulate the CCR5 co-receptors, thereby preventing transmission of M-tropic HIV-1. The objective of this investigation was to evaluate this mechanism in vivo
- Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice.
- Immunology. 2000 Apr;99(4):615-24. Unique Identifier : AIDSLINE MED/20253158
- Sakai T; Hisaeda H; Nakano Y; Ishikawa H; Maekawa Y; Ishii K; Nitta Y; Miyazaki J; Himeno K; Department of Parasitology and Immunology, University of; Tokushima School of Medicine, Tokushima, Japan.
- An interleukin-12 (IL-12) expression plasmid was transferred, using a gene gun, to mice infected with Leishmania major or Trypanosoma cruzi. Transfer of the IL-12 gene to susceptible BALB/c mice resulted in regression of lesion size and reduced the number of parasites in draining lymph nodes (LN) at the site of L. maj
- Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.
- Immunol Cell Biol. 2000 Apr;78(2):110-7. Unique Identifier : AIDSLINE MED/20225765
- Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR; Immunology Division, The Walter and Eliza Hall Institute of; Medical Research, Melbourne, Victoria, Australia.
- The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I-restricted, ovalbumin-specific, CD8+ T cells (OT-I cells). These cells are shown to be positively selected in vivo in H-2b C57BL/6 mice and in bm5 mice, which express the Kbm5 mutant molecule. I
- Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?
- Immunol Cell Biol. 2000 Apr;78(2):166-75. Unique Identifier : AIDSLINE MED/20225773
- Rincon M; Conze D; Weiss L; Diehl NL; Fortner KA; Yang D; Flavell RA; Enslen H; Whitmarsh A; Davis RJ; Immunobiology Program, Department of Medicine, University of; Vermont, Burlington, Vermont 05405, USA. mrincon@zoo.uvm.edu
- Mitogen-activated protein (MAP) kinases, which include the extracellular response kinases, p38 and c-Jun amino terminal kinases (JNK), play a significant role in mediating signals triggered by cytokines, growth factors and environmental stress. The JNK and p38 MAP kinases have been involved in growth, differentiation
- Pulmonary manifestations of pediatric HIV infection.
- Indian J Pediatr. 1999 Nov-Dec;66(6):895-904. Unique Identifier : AIDSLINE MED/20258492
- Khare MD; Sharland M; Pediatric Infectious Diseases Unit, St. George's Hospital,; London, United Kingdom.
- Vertically acquired HIV infection is becoming increasingly common in India . The main clinical manifestations of HIV in childhood are growth failure, lymphadenopathy, chronic cough and fever, recurrent pulmonary infections, and persistent diarrhoea. Pulmonary disease is the major cau
- Dermatologic manifestations among human immunodeficiency virus patients in south India.
- Int J Dermatol. 2000 Mar;39(3):192-5. Unique Identifier : AIDSLINE MED/20223446
- Kumarasamy N; Solomon S; Madhivanan P; Ravikumar B; Thyagarajan SP; Yesudian P; YRG Center for AIDS Research and Education, and University of; Madras, Madras, India.
- BACKGROUND: Human immunodeficiency virus (HIV) may be associated with a large number of dermatologic manifestations, which may at times constitute the presenting symptoms. These skin lesions are well delineated in the Western literature, but there is a paucity of information from the southern part of the Indian subcon
- Experience with low-dose thalidomide therapy in chronic discoid lupus erythematosus.
- Int J Dermatol. 2000 Mar;39(3):218-22. Unique Identifier : AIDSLINE MED/20223455
- Kyriakis KP; Kontochristopoulos GJ; Panteleos DN; Department of Dermatology, The West Attica General Hospital and; Leprosy Center, Athens, Greece.
- BACKGROUND: Low-dose thalidomide therapy (median dose 100 mg/day, 50-200 mg/day) in chronic discoid lupus erythematosus was studied with regard to efficacy, tolerance, and toxicity in 22 patients. Intense contraceptive precautions were taken in women patients of childbearing age. METHODS: An open uncontrolled trial wa
- Risk of transmission of blood-borne viral infection in orthopaedic and trauma surgery.
- J Bone Joint Surg Br. 2000 Apr;82(3):313-23. Unique Identifier : AIDSLINE MED/20271269
- Lemaire R; Masson JB; Department of Orthopaedics and Traumatology, University Hospital; (Centre Hospitalier Universitaire), Liege, Belgium.
- Decision-making in HIV prevention community planning: an integrative review.
- J Community Health. 2000 Apr;25(2):95-112. Unique Identifier : AIDSLINE MED/20252178
- Johnson-Masotti AP; Pinkerton SD; Holtgrave DR; Valdiserri RO; Willingham M; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53202, USA.
- Since 1994, the Centers for Disease Control and Prevention has required that the 65 health department grantees that receive funding for HIV prevention interventions engage in a community planning process to involve affected communities in local prevention decision making; to increase the use of epidemiological data to
- A painful cutaneous nodule as the presentation of metastatic transitional cell carcinoma of the renal pelvis.
- J Am Acad Dermatol. 2000 May;42(5 Pt 2):867-8. Unique Identifier : AIDSLINE MED/20231903
- Zirwas MJ; Hunt S; Logan TF; Abernethy JL; Seraly MP; University of Pittsburgh School of Medicine, the Departments of; Internal Medicine and Dermatology, Pittsburgh, PA, USA.
- We report a 43-year-old man with HIV who presented with a painful, vascular-appearing nodule as the initial manifestation of metastasis of a prior transitional cell carcinoma of the renal pelvis. The transitional cell carcinoma had been treated by nephroureterectomy 4 years before the appearance of the nodule. Histopa
- AIDS in Latin America.
- Infect Dis Clin North Am. 2000 Mar;14(1):185-209. Unique Identifier : AIDSLINE MED/20203166
- Cahn P; Belloso WH; Murillo J; Prada-Trujillo G; Department of Infectious Diseases, University of Buenos Aires; School of Medicine, Argentina.
- The epidemic in Latin America has placed an unexpected additional burden on the health care systems and national economies, already weak and affected by severe problems. Specific regional diseases in addition to common opportunistic infections, and particularly the high incidence of TB, produce a different picture com
- Human T-cell lymphotropic virus-I in Latin America.
- Infect Dis Clin North Am. 2000 Mar;14(1):211-39, x-xi. Unique Identifier : AIDSLINE MED/20203167
- Gotuzzo E; Arango C; de Queiroz-Campos A; Isturiz RE; Alexander von Humboldt Institute of Tropical Medicine, Hospital; Nacional Cayetano Heredia, Lima, Peru. egh@upch.edu.pe
- HTLV-1 infection is endemic in several Latin American countries. HTLV-1-associated myelophathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia lymphoma (ATLL) are emerging diseases in the region. Documented risk factors for acquiring the virus include breast-feeding, contaminated blood transfusion, an
- Lack of detection of human herpesvirus (HHV)-8 DNA in lesional skin of German pemphigus vulgaris and pemphigus foliaceus patients [letter]
- J Invest Dermatol. 2000 Apr;114(4):739-41. Unique Identifier : AIDSLINE MED/20213492
- Bezold G; Sander CA; Flaig MJ; Peter RU; Messer G
- The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapy.
- Unique Identifier : AIDSLINE MED/20227747
- Binley JM; Schiller DS; Ortiz GM; Hurley A; Nixon DF; Markowitz MM; Moore JP; The Aaron Diamond AIDS Research Center, The Rockefeller; University, New York, NY 10016, USA. jbinley@adarc.org
- The relationship between human immunodeficiency virus (HIV) type 1 replication and CD4+ T cell function was examined. T lymphocyte proliferation in response to both HIV-1 antigens and recall antigens was measured in HIV-1-infected individuals before and after they received highly active antiretroviral therapy (HAART).
- Strong human immunodeficiency virus (HIV)-specific CD4+ T cell responses in a cohort of chronically infected patients are associated with interruptions in anti-HIV chemotherapy.
- J Infect Dis. 2000 Apr;181(4):1264-72. Unique Identifier : AIDSLINE MED/20227748
- Haslett PA; Nixon DF; Shen Z; Larsson M; Cox WI; Manandhar R; Donahoe SM; Kaplan G; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, NY 10021, USA.; hasletp@rockvax.rockefeller.edu
- Virus-specific CD4+ T-helper cell function is important in controlling human immunodeficiency virus (HIV) infection but is impaired in patients with progressive HIV disease. It has been reported that after highly active antiretroviral therapy (HAART), HIV-specific lymphoproliferative responses remain absent, whereas r
- Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor--sparing highly active antiretroviral therapy.
- J Infect Dis. 2000 Apr;181(4):1273-9. Unique Identifier : AIDSLINE MED/20294194
- Dybul M; Chun TW; Ward DJ; Hertogs K; Larder B; Fox CH; Orenstein JM; Baird BF; Li Y; Green LG; Engel D; Liu S; Mican JM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institute of Health, Bethesda, MD; 20892, USA. mdybul@nih.gov
- Although efavirenz-containing regimens effectively suppress plasma levels of human immunodeficiency virus (HIV) RNA, it is now clear that undetectable plasma viremia may not reflect a lack of viral replication. Because lymphoid tissue is an active site of HIV replication, the lymph node virus burden was analyzed in pe
- Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement.
- J Infect Dis. 2000 Apr;181(4):1280-8. Unique Identifier : AIDSLINE MED/20227749
- Ledergerber B; Flepp M; Boni J; Tomasik Z; Cone RW; Luthy R; Schupbach J; Division of Infectious Diseases, Department of Medicine, Zurich; University Hospital, Zurich, Switzerland.
- Human immunodeficiency virus type 1 (HIV-1) RNA and p24 antigen concentrations were determined in plasma samples from 169 chronically infected patients (median CD4 cell count, 140 cells/microL; range, 0-1500 cells/microL). p24 quantification involved heat-mediated immune complex dissociation and tyramide signal amplif
- Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: A randomized, double-blind, placebo-controlled trial. The AIDS Clinical Trials Group 196/Terry Beirn Community Programs for Clinical Research on AIDS 009 Protocol Team.
- J Infect Dis. 2000 Apr;181(4):1289-97. Unique Identifier : AIDSLINE MED/20227750
- Benson CA; Williams PL; Cohn DL; Becker S; Hojczyk P; Nevin T; Korvick JA; Heifets L; Child CC; Lederman MM; Reichman RC; Powderly WG; Notario GF; Wynne BA; Hafner R; Rush Medical College/Rush-Presbyterian-St. Luke's Medical Center,; Chicago, IL, USA. constance.benson@uchsc.edu
- The efficacy and safety of clarithromycin and rifabutin alone and in combination for prevention of Mycobacterium avium complex (MAC) disease were compared in 1178 patients with AIDS who had
- Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis.
- J Infect Dis. 2000 Apr;181(4):1298-303. Unique Identifier : AIDSLINE MED/20227751
- Hazra R; Lee SH; Maslow JN; Husson RN; Division of Infectious Diseases, Children's Hospital, and; Department of Pediatrics, Harvard Medical School, Boston, MA; 02115, USA.
- Sequence analysis of the ribosomal internal transcribed spacer of 56 Mycobacterium avium complex isolates from pediatric patients with AIDS or lymphadenitis revealed (similar to the situation in adults) that the closely related Mav-B and Mav-A sequevars caused the vast majority of disease. IS1245 restriction fragment-
- Randomized controlled trial of Mycobacterium vaccae immunotherapy in non-human immunodeficiency virus-infected ugandan adults with newly diagnosed pulmonary tuberculosis. The Uganda-Case Western Reserve University Research Collaboration.
- J Infect Dis. 2000 Apr;181(4):1304-12. Unique Identifier : AIDSLINE MED/20227752
- Johnson JL; Kamya RM; Okwera A; Loughlin AM; Nyole S; Hom DL; Wallis RS; Hirsch CS; Wolski K; Foulds J; Mugerwa RD; Ellner JJ; Department of Medicine, Division of Infectious Diseases, Case; Western Reserve University, Tuberculosis Research Unit,; Cleveland, OH 44106-4984, USA. jlj@po.cwru.edu
- Adjunctive immunotherapy with heat-killed Mycobacterium vaccae was studied in a randomized, placebo-controlled trial of 120 non-human immunodeficiency virus-infected adults with newly diagnosed pulmonary tuberculosis. Patients were randomized to a single dose of M. vaccae or placebo 1 week after beginning chemotherapy
- A pneumococcal capsular polysaccharide vaccine induces a repertoire shift with increased VH3 expression in peripheral B cells from human immunodeficiency virus (HIV)-uninfected but not HIV-infected persons.
- J Infect Dis. 2000 Apr;181(4):1313-21. Unique Identifier : AIDSLINE MED/20227753
- Chang Q; Abadi J; Alpert P; Pirofski L; Departments of Microbiology and Immunology, Division of; Infectious Diseases, and Montefiore Hospital and Medical Center,; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- The molecular mechanism of pneumococcal vaccine failure in human immunodeficiency virus (HIV)-infected persons is not fully understood. A polymerase chain reaction ELISA was used to determine the proportion of peripheral IgG, IgA, and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (V
- A hospital-based prevalence survey of bloodstream infections in febrile patients in Malawi: implications for diagnosis and therapy.
- J Infect Dis. 2000 Apr;181(4):1414-20. Unique Identifier : AIDSLINE MED/20227765
- Archibald LK; McDonald LC; Nwanyanwu O; Kazembe P; Dobbie H; Tokars J; Reller LB; Jarvis WR; Hospital Infections Program, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA. lca6@cdc.gov
- The etiology of bloodstream infections (BSIs) in febrile (> or =37.5 degrees C) adults (> or =18 years old) in one Malawi hospital were determined during August and September 1997. After clinical evaluation, blood was drawn for comprehensive culture, human immunodeficiency virus (H
- Coccidioidomycosis in human immunodeficiency virus-infected persons in Arizona, 1994-1997: incidence, risk factors, and prevention.
- J Infect Dis. 2000 Apr;181(4):1428-34. Unique Identifier : AIDSLINE MED/20227767
- Woods CW; McRill C; Plikaytis BD; Rosenstein NE; Mosley D; Boyd D; England B; Perkins BA; Ampel NM; Hajjeh RA; Epidemic Intelligence Service, Epidemiology Program Office, and; Division of Bacterial and Mycotic Diseases, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, GA 30307, USA.
- From 1 January 1995 through 31 June 1997, 153 cases of coccidioidomycosis in human immunodeficiency virus (HIV)-infected persons were identified in Arizona (incidence, 41/1000 persons living with AIDS). A case-control study was conducted to evaluate risk factors for
- Risk factors for acute symptomatic coccidioidomycosis among elderly persons in Arizona, 1996-1997.
- J Infect Dis. 2000 Apr;181(4):1435-40. Unique Identifier : AIDSLINE MED/20227768
- Leake JA; Mosley DG; England B; Graham JV; Plikaytis BD; Ampel NM; Perkins BA; Hajjeh RA; Epidemic Intelligence Service, Epidemiology Program Office, and; Division of Bacterial and Mycotic Diseases, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.
- Because of the increase in incidence of coccidioidomycosis among the elderly in Arizona between 1990 and 1996, a case-control study was conducted to look at risk factors for disease among these persons. Cases (n=89) were persons aged > or =60 years with laboratory-co
- Human herpesvirus-6 is associated with cytomegalovirus reactivation in liver transplant recipients.
- J Infect Dis. 2000 Apr;181(4):1450-3. Unique Identifier : AIDSLINE MED/20227771
- Humar A; Malkan G; Moussa G; Greig P; Levy G; Mazzulli T; Department of Medicine, Division of Infectious Diseases and; Multi-Organ Transplantation, Toronto General Hospital-University; Health Network, Toronto, Ontario M5G 2C4, Canada.; Atul.Humar@uhn.on.ca
- Human herpesvirus-6 (HHV-6) may be a risk factor for cytomegalovirus ( CMV ) disease in posttransplant patients, possibly through a direct interaction or through a general immunomodulatory effect. To examine this possibility, 8
- Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort Study.
- J Infect Dis. 2000 Apr;181(4):1475-8. Unique Identifier : AIDSLINE MED/20227777
- Hisada M; O'Brien TR; Rosenberg PS; Goedert JJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, MD 20852, USA.; mh280i@nih.gov
- A high human immunodeficiency virus (HIV) load may increase the probability of HIV transmission by sexual contact, but the association of virus load of hepatitis C virus (HCV) with risk of HCV transmission is uncertain. HIV and HCV virus loads were examined in hemophilic men, as were risks of HIV and HCV transmission
- Effect of HIV on thymic function before and after antiretroviral therapy in children.
- J Infect Dis. 2000 Apr;181(4):1479-82. Unique Identifier : AIDSLINE MED/20227778
- Douek DC; Koup RA; McFarland RD; Sullivan JL; Luzuriaga K; Department of Internal Medicine and Microbiology, University of; Texas Southwestern Medical Center, Dallas, TX 75235-9113, USA.; daniel.douek@email.swmed.edu
- Studies were undertaken to investigate the role of the thymus in T cell reconstitution in human immunodeficiency virus (HIV)-infected children treated with antiretroviral therapy. Nine pediatric patients who acquired HIV perinatally were treated with multidrug combinations of antiretroviral agents. Plasma virus load a
- Haptoglobin polymorphism in human immunodeficiency virus infection: Hp0 phenotype limits depletion of CD4 cell counts in HIV-1-seropositive individuals.
- J Infect Dis. 2000 Apr;181(4):1483-5. Unique Identifier : AIDSLINE MED/20227779
- Quaye IK; Brandful J; Ekuban FA; Gyan B; Ankrah NA; Chemical Pathology Unit, Noguchi Memorial Institute for Medical; Research, University of Ghana, Accra, Ghana.; iquaye@noguchi.mimcom.net
- Patients seropositive for human immunodeficiency virus (HIV) type 1 and seronegative control subjects were categorized by their haptoglobin phenotypes, which were determined by electrophoresis of hemoglobin-supplemented plasma samples followed by benzidine staining. The CD4 cell counts, determined by flow cytometry fr
- Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: results of AIDS clinical trials group protocol 853.
- J Infect Dis. 2000 Apr;181(4):1486-90. Unique Identifier : AIDSLINE MED/20227780
- MacArthur RD; Lederman MM; Benson CA; Chernoff MC; MacGregor RR; Spritzler J; Mahon LF; Yen-Lieberman B; Purvis S; Wayne State University, Department of Medicine, Division of; Infectious Diseases, Detroit, MI 48201, USA.; macarthur@intmed.wayne.edu
- Human immunodeficiency virus (HIV) type 1-infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-alpha levels. Blood specimens were obtained fo
- Questions about results reported with potent antiretroviral therapy for human immunodeficiency virus type 1 infection [letter]
- J Infect Dis. 2000 Apr;181(4):1518-20. Unique Identifier : AIDSLINE MED/20227788
- Papadopulos-Eleopulos E; Turner VF; Papadimitriou JM; Alfonso H; Page B; Causer D
- Interleukin 12 and innate molecules for enhanced mucosal immunity.
- Immunol Res. 1999;20(3):207-17. Unique Identifier : AIDSLINE MED/20203905
- Boyaka PN; Lillard JW Jr; McGhee J; The Immunobiology Vaccine Center, The University of Alabama at; Birmingham, 35294-2170, USA.
- Recent strategies for understanding the mechanisms underlying mucosal immune responses and subsequent development of mucosal vaccines for induction of targeted immunity now include cytokines and molecules of innate immunity. These studies have shown that cytokines influencing the development of T helper (Th) cells dif
- The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense.
- Immunol Res. 1999;20(3):219-35. Unique Identifier : AIDSLINE MED/20203906
- Yoshikai Y; Laboratory of Host Defense, Research Institute for Disease for; Mechanism and Control, Nagoya University School of Medicine,; Japan. yoshika@med.nagoya-u.ac.jp
- Intestinal intraepithelial lymphocytes (i-IEL) are located at the basolateral surfaces of intestinal epithelial cells (i-EC) and play important roles in the homeostasis of intestinal microenvironment. i-IEL comprise unique T cell populations including CD4-CD8alphaalpha+ T cells expressing T cell receptor (TCR)alphabet
- Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease.
- Immunol Res. 1999;20(3):237-42. Unique Identifier : AIDSLINE MED/20203907
- Takahashi I; Lijima H; Kishi D; Kiyono H; Department of Mucosal Immunology, Research Institute for; Microbial Diseases, Osaka University, Suita-Osaka, Japan.; snatum@biken.osaka-u.ac.jp
- A population of CD4+ T cells with TCR beta-chain without TCR alpha-chain (CD4+, betabeta T cells) producing Th2-type cytokines increased in the mucosal and peripheral tissues of TCR alpha-chain deficient mice with inflammatory bowel disease (IBD). Analysis of TCR-beta immunoprecipitates by two-dimensional electrophore
- New gut associated lymphoid tissue "cryptopatches" breed murine intestinal intraepithelial T cell precursors.
- Immunol Res. 1999;20(3):243-50. Unique Identifier : AIDSLINE MED/20203908
- Ishikawa H; Saito H; Suzuki K; Oida T; Kanamori Y; Department of Microbiology, Keio University School of Medicine,; Tokyo, Japan. ishikawa@sun.microb.med.keio.ac.jp
- Numerous mouse intraepithelial T cells (IEL) bearing either TCR-alphabeta or TCR-gammadelta have been shown to develop somewhere in the intestinal mucosa without passing through the thymus. However, just where these T cells develop has been much less clear and has remained an open question to date. In an effort to inv
- The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity.
- J Leukoc Biol. 2000 May;67(5):607-14. Unique Identifier : AIDSLINE MED/20269136
- Clarke SR; Howard Hughes Medical Institute and Department of Immunology,; University of Washington School of Medicine, Seattle 98195-7370,; USA. clarkes@u.washington.edu
- Control of virus infections and eradication of tumors usually involves the lytic activity of CD8+ cytotoxic T lymphocytes (CTLs). The induction of effective CTL immunity relies on several factors, one of the most important of which is CD4+ T cell help. Numerous studies have demonstrated the dependence of CTL priming o
- CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons [see comments]
- J Exp Med. 2000 May 1;191(9):1459-66. Unique Identifier : AIDSLINE MED/20253233
- Liu T; Khanna KM; Chen X; Fink DJ; Hendricks RL; Department of Ophthalmology, University of Pittsburgh, School of; Medicine, Pittsburgh, Pennsylvania 15213, USA.
- Recurrent herpes simplex virus type 1 (HSV-1) disease usually results from reactivation of latent virus in sensory neurons and transmission to peripheral sites. Therefore, defining the mechanisms that maintain HSV-1 in a latent state in sensory neurons may provide new approaches to reducing susceptibility to recurrent
- Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses.
- J Exp Med. 2000 May 1;191(9):1605-10. Unique Identifier : AIDSLINE MED/20253246
- He J; Gurunathan S; Iwasaki A; Ash-Shaheed B; Kelsall BL; Immune Cell Interaction Unit, Mucosal Immunity Section,; Laboratory of Clinical Investigation, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892, USA.
- We explored the role of Gi protein signaling in the regulation of interleukin (IL)-12 production and T helper cell type 1 (Th1) T cell differentiation. In initial studies, we showed that treatment of normal mice with pertussis toxin (PT), which inhibits Gi protein signaling, enhanced the capacity of splenocytes to pro
- A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma.
- J Exp Med. 2000 May 1;191(9):1617-24. Unique Identifier : AIDSLINE GENBANK/AF164963
- Moreau-Aubry A; Le Guiner S; Labarriere N; Gesnel MC; Jotereau F; Breathnach R; Institut National de la Sante et de la Recherche Medicale; (INSERM) U463, 44093 Nantes cedex 01, France.
- The M88.7 T cell clone recognizes an antigen presented by HLA B*1302 on the melanoma cell line M88. A cDNA encoding this antigen (NA88-A) was isolated using a library transfection approach. Analysis of the genomic gene s sequence identified it is a processed pseudogene, derived from a retrotranscript of mRNA coding fo
- HTLV-1 and HIV infections of the central nervous system in tropical areas.
- J Neurol Neurosurg Psychiatry. 2000 May;68(5):550-7. Unique Identifier : AIDSLINE MED/20229910
- Cabre P; Smadja D; Cabie A; Newton CR; Department of Neurology, University Hospital of Fort-de-France,; Martinique, French West Indies.
- Global 3D-QSAR methods: MS-WHIM and autocorrelation.
- J Comput Aided Mol Des. 2000 Mar;14(3):293-306. Unique Identifier : AIDSLINE MED/20219970
- Gancia E; Bravi G; Mascagni P; Zaliani A; Italfarmaco Research Centre, Milan, Italy.; emanuelagancia@chiroscience.com
- The recently proposed MS-WHIM indices, a set of theoretical descriptors containing information about size, shape and electrostatic distribution of a molecule, have been further investigated. The main objectives of this work were: (i) to confirm the descriptive power of MS-WHIM in modelling specific biological interact
- Use of cultured cerebral capillary endothelial cells in modeling the central nervous system availability of 2',3'-dideoxyinosine.
- J Pharm Sci. 2000 Mar;89(3):322-35. Unique Identifier : AIDSLINE MED/20173669
- Johnson MD; Anderson BD; Department of Pharmaceutics and Pharmaceutical Chemistry,; University of Utah, Salt Lake City, Utah 84112, USA.
- The biochemical and physiological mechanisms responsible for the limited central nervous system (CNS) uptake of dideoxynucleoside reverse transcriptase inhibitors currently used to treat HIV-1 infection in humans are poorly understood. In vitro models of the blood-brain barrier (BBB) offer an attractive alternative to
- Africa needs more aid, new partnerships to fight malaria [news]
- JAMA. 2000 May 17;283(19):2510, 2513. Unique Identifier : AIDSLINE MED/20275996
- Voelker R
- From the Centers for Disease Control and Prevention. HIV-related tuberculosis in a transgender Network--Baltimore, Maryland, and New York City Area, 1998-2000.
- JAMA. 2000 May 17;283(19):2515-6. Unique Identifier : AIDSLINE MED/20294196
- Elevated liver enzymes following initiation of antiretroviral therapy [letter; comment]
- JAMA. 2000 May 17;283(19):2526-7. Unique Identifier : AIDSLINE MED/20276013
- Velasco M; Guijarro C
- Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: a collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Concerted Action on SeroConversion to AIDS and Death in Europe.
- Lancet. 2000 Apr 1;355(9210):1131-7. Unique Identifier : AIDSLINE MED/20250014
- BACKGROUND: We used data from Europe, North America, and Australia to assess the effect of exposure category on the AIDS incubation period and HIV-1 survival and whether the effect of age at seroconversion varies with exposure category and with time since seroconversion. METHODS
- Survival after introduction of HAART in people with known duration of HIV-1 infection. The CASCADE Collaboration. Concerted Action on SeroConversion to AIDS and Death in Europe [letter]
- Unique Identifier : AIDSLINE MED/20250022
- We compared survival from HIV-1 seroconversion before and during the periods of highly-active antiretroviral therapy (HAART).
- Questioning of HIV theory of AIDS causes dismay in South Africa [news]
- Lancet. 2000 Apr 1;355(9210):1167. Unique Identifier : AIDSLINE MED/20250030
- Baleta A
- Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy.
- Neurology. 2000 May 9;54(9):1856-9. Unique Identifier : AIDSLINE MED/20264465
- d'Arminio Monforte A; Duca PG; Vago L; Grassi MP; Moroni M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy. a-darm1@mailserver.unimi.it
- The authors enrolled 1,029 patients with CD4 counts
- Predictive markers of clinical outcome in vertically HIV-1-infected infants. A prospective longitudinal study.
- Pediatr Res. 2000 Apr;47(4 Pt 1):509-15. Unique Identifier : AIDSLINE MED/20220909
- Resino S; Gurbindo D; Cano JM; Sanchez-Ramon S; Muoz-Fernandez MA; Division of Immunology, Hospital General Universitario Gregorio; Maranon, Madrid, Spain.
- We have investigated the relationship between disease progression and several immunologic and virologic markers of HIV infection. Plasma samples from infants born to HIV-1-infected mothers were collected at birth and at 1, 2, 4, 6, 9, 12, 15, and 18 mo of age and subsequently were assayed every 6 mo for viral load, vi
- [Use of urinary beta-hexosaminidase for diagnosing alcoholism in persons with opiate dependency in a methadone substitution program]
- Psychiatr Pol. 1999 Mar-Apr;33(2):215-23. Unique Identifier : AIDSLINE MED/20247950
- Taracha E; Habrat B; Chmielewska K; Baran H; Szukalski B; Zakladu Biochemii IPiN w Warszawie.
- Usefulness of urinary beta-hexosaminidase determinations in patients on methadone substitution to pinpoint cases of alcohol abuse was studied. It was found that methadone, illegal drugs and HIV seropositivity had no effect upon the activity of this enzyme. The enzyme activity was significantly higher in patients who a
- Human immunodeficiency virus bDNA assay for pediatric cases.
- Rev Argent Microbiol. 2000 Jan-Mar;32(1):33-8. Unique Identifier : AIDSLINE MED/20247665
- Avila MM; Liberatore D; Martinez Peralta L; Biglione M; Libonatti O; Coll Cardenas P; Hodara VL; Departamento de Microbiologia, Facultad de Medicina, Universidad; de Buenos Aires, Piso, Argentina.
- Techniques to quantify plasma HIV-1 RNA viral load (VL) are commercially available, and they are adequate for monitoring adults infected by HIV and treated with antiretroviral drugs. Little experience on HIV VL has been reported in pediatric cases. In Argentina , the evaluation o
- [Use of polymerase chain reaction in medical diagnosis]
- Przegl Lek. 1999;56(11):723-34. Unique Identifier : AIDSLINE MED/20260380
- Swiat A; Stepien E; Andres J; Dziatkowiak A; Katedry Anestezjologii i Intensywnej Terapii, Collegium Medicum,; Uniwersytetu Jagiellonskiego w Krakowie.
- Principles of the polymerase chain reaction (PCR) and its modifications are discussed: reverse transcription-PCR (RT-PCR), nested PCR, restriction fragment length polymorphism-PCR (RFLP-PCR). Different methods of the PCR products detection used in routine diagnostics and research are presented: electrophoresis and chr
- [Stevens-Johnson syndrome due to nevirapine (letter)]
- Rev Clin Esp. 2000 Mar;200(3):179-80. Unique Identifier : AIDSLINE MED/20264892
- Garcia Fernandez D; Garcia-Patos Briones V; Mollet Sanchez J; Castells Rodellas A
- [AIDS and anesthesia]
- Rev Esp Anestesiol Reanim. 2000 Mar;47(3):114-25, 129. Unique Identifier : AIDSLINE MED/20260156
- Una Orejon R; Ureta Tolsada P; Una Orejon S; Maseda Garrido E; Criado Jimenez A; Servicio de Anestesiologia y Reanimacion, Hospital General La; Paz, Madrid.
- AIDS concerns anaesthetic practice for various reasons. First, this syndrome can affect different organs that have anaesthetic implications. Second, drugs usually taken by the patient can interact with anaesthetic agents. And last, the risk of infection for health workers must be taken into account, as well as the pro
- Characterization of reactivation of cytomegalovirus retinitis in patients healed after treatment with highly active antiretroviral therapy.
- Retina. 2000;20(2):151-5. Unique Identifier : AIDSLINE MED/20244533
- Song MK; Karavellas MP; MacDonald JC; Plummer DJ; Freeman WR; Shiley Eye Center, University of California, San Diego; 92093-0946, USA.
- PURPOSE: To delineate the immune parameters associated with reactivation of cytomegalovirus ( CMV ) retinitis in patients for whom highly active antiretroviral therapy (HAART) was not successful. METHODS: Prospective, longitudi
- Exudative retinal detachment and retinitis associated with acquired syphilitic uveitis.
- Retina. 2000;20(2):190-4. Unique Identifier : AIDSLINE MED/20244539
- Jumper JM; Machemer R; Gallemore RP; Jaffe GJ; Department of Ophthalmology, Wilford Hall Medical Center,; Lackland Air Force Base, Texas, USA.
- PURPOSE: To describe three cases of exudative retinal detachment and focal retinitis associated with acquired syphilitic uveitis. METHODS: Three patients who were referred for evaluation of uveitis were examined. Slit-lamp examination, ophthalmoscopy, B-scan ultrasonography, fundus photography, and fluorescein angiogr
- Participatory diagramming as a means to improve communication about sex in rural Zimbabwe: a pilot study.
- Soc Sci Med. 2000 Jun;50(12):1723-41. Unique Identifier : AIDSLINE MED/20256186
- Kesby M; School of Geography and Geosciences, University of St Andrews,; Fife, Scotland, UK. mike.kesby@st-and.ac.uk
- It is increasingly recognised that unequal gender relations and poor communication between men and women about sexual matters, play a central role in the rapid transmission of HIV in sub-Saharan Africa. Analysis of how communication might practically be improved remains a critical area for investigation however. To th
- Impact of natural chemokine receptor polymorphisms on perinatal transmission of human immunodeficiency virus type 1.
- Teratology. 2000 May;61(5):387-90. Unique Identifier : AIDSLINE MED/20242079
- Kostrikis LG; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA. lkostrik@adarc.org
- Role of the placenta in fetal HIV infection.
- Teratology. 2000 May;61(5):391-4. Unique Identifier : AIDSLINE MED/20242080
- Miller RK; Polliotti BM; Laughlin T; Gnall S; Iida S; Carneiro M; Lord K; Ding Y; Sheikh AU; Departments of Obstetrics and Gynecology and of Environmental; Medicine, University of Rochester, School of Medicine and; Dentistry, Rochester, New York 14642-8668, USA.; richardk_miller@urmc.rochester.edu
- Follow-up of children exposed to perinatal antiretrovirals.
- Teratology. 2000 May;61(5):395-6. Unique Identifier : AIDSLINE MED/20242081
- Fowler MG; MCTPASS/Epidemiology Branch, Division of HIV/AIDS-SE, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.
- Potential toxicities of HIV therapeutics in the developing infant.
- Teratology. 2000 May;61(5):397-8. Unique Identifier : AIDSLINE MED/20242082
- Slikker W Jr; Olivero OA; Patterson TA; Poirier MC; Division of Neurotoxicology, NCTR, Food and Drug Administration,; Jefferson, Arkansas 72079-9502, USA. wslikker@nctr.fda.gov
- Competition by allelopathy proceeds in traveling waves: colicin-immune strain aids colicin-sensitive strain.
- Theor Popul Biol. 2000 Mar;57(2):131-44. Unique Identifier : AIDSLINE MED/20255631
- Nakamaru M; Iwasa Y; Department of Biology, Kyushu University, CREST, Japan Science; and Technology Corporation, Fukuoka, 812-8581, Japan.
- Producing toxic chemicals to suppress both the growth and survivorship of local competitors is called allelopathy; some strains of the bacteria Escherichia coli produce a toxin (named colicin) which may kill colicin-sensitive neighbors while they themselves are immune. In a previous paper, the competitive outcome betw
- Fusion mediated by the HIV-1 envelope protein.
- Subcell Biochem. 2000;34:457-81. Unique Identifier : AIDSLINE MED/20268386
- McManus CM; Doms RW; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.
- Prevalence, patterns, and course of past hepatitis B virus infection in intravenous drug users with HIV-1 infection.
- Am J Gastroenterol. 2000 May;95(5):1316-22. Unique Identifier : AIDSLINE MED/20269483
- Rodriguez-Mendez ML; Gonzalez-Quintela A; Aguilera A; Barrio E; Department of Internal Medicine, Complejo Hospitalario; Universitario, Santiago de Compostela, Spain.
- OBJECTIVE: Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) share common routes of transmission. Therefore, markers of either active or past HBV infection are present in many HIV-infected patients, particularly in intravenous drug users (IDUs). The aim of this study was to analyze the serological pattern
- Treatment of the wrong disease with the right medication: a case of generalized leishmaniasis involving the liver and the gastrointestinal tract [letter]
- Am J Gastroenterol. 2000 May;95(5):1377. Unique Identifier : AIDSLINE MED/20269507
- Olofinlade O; Cacciarelli A
- HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype.
- Am J Hematol. 2000 May;64(1):64-6. Unique Identifier : AIDSLINE MED/20273212
- Nakase K; Hasegawa M; Tsuji K; Ikeda T; Tamaki S; Tanigawa M; Miyanishi E; Shiku H; Department of Internal Medicine, Saiseikai Matsusaka Hospital,; Mie, Japan.
- We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reactio
- Polycythemia in patients infected with human immunodeficiency virus-1 [letter]
- Am J Hematol. 2000 May;64(1):80-1. Unique Identifier : AIDSLINE MED/20273220
- Koduri PR; Sherer R; Teter C
- Prevalence of HIV-associated nephropathy in autopsies of HIV-infected patients.
- Am J Kidney Dis. 2000 May;35(5):884-8. Unique Identifier : AIDSLINE MED/20255117
- Shahinian V; Rajaraman S; Borucki M; Grady J; Hollander WM; Ahuja TS; Department of Medicine, University of Texas Medical Branch,; Galveston, TX 77555, USA.
- Previous studies have reported that approximately 10% of the patients with human immunodeficiency virus (HIV) infection develop HIV-associated nephropathy (HIVAN). However, over the last decade, morbidity and mortality as a result of HIV-1 infection has remarkably decreased with the availability of potent new antiretr
- Evaluation of rapid diagnostic tests for the detection of human immunodeficiency virus types 1 and 2, hepatitis B surface antigen, and syphilis in Ho Chi Minh City, Vietnam.
- Am J Trop Med Hyg. 2000 Feb;62(2):301-9. Unique Identifier : AIDSLINE MED/20271597
- Lien TX; Tien NT; Chanpong GF; Cuc CT; Yen VT; Soderquist R; Laras K; Corwin A; Pasteur Institute, Ho Chi Minh City, Vietnam.
- An evaluation of three new rapid diagnostic test kits for human immunodeficiency virus types 1 and 2 (HIV-1/2), hepatitis B surface antigen (HBsAg), and syphilis involved a two-phase comparison of rapid diagnostic assays using prospectively collected from hospitals and clinics in Ho Chi Minh City,
- Trimethoprim-sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospara belli and Cyclospora cayetanensis infection in HIV-infected patients. A randomized, controlled trial.
- Ann Intern Med. 2000 Jun 6;132(11):885-8. Unique Identifier : AIDSLINE MED/20279646
- Verdier RI; Fitzgerald DW; Johnson WD Jr; Pape JW; Cornell University Medical College, New York, New York 10021,; USA.
- BACKGROUND: In developing countries, Isospora belli and Cyclospora cayetanensis frequently cause chronic diarrhea in HIV-infected patients. OBJECTIVE: To compare 1 week of trimethoprim-sulfamethoxazole treatment and 1 week of ciprofloxacin treatment in HIV-infected patients with chronic diarrhea caused by I. belli and
- Name-based surveillance for HIV-infected persons [letter]
- Ann Intern Med. 2000 Jun 6;132(11):922-3. Unique Identifier : AIDSLINE MED/20279655
- Brewer DD; Potterat JJ
- Ethical aspects of reproduction in the next century.
- Ann N Y Acad Sci. 2000;900:357-74. Unique Identifier : AIDSLINE MED/20278366
- Fasouliotis SJ; Schenker JG; Department of Obstetrics and Gynecology, Hebrew University,; Hadassah Medical Center, Jerusalem, Israel.
- Doubtless, the technological advancements achieved in the current century in the area of young women s reproductive health care have also led to the evolution of very important ethical issues that will have to be dealt with in the coming century. Abortion, perhaps the most controversial issue of all, continues to rais
- Treatment of recurrent Kaposi's sarcoma of an AIDS patient with weekly paclitaxel.
- Anticancer Res. 2000 Mar-Apr;20(2B):1159-61. Unique Identifier : AIDSLINE MED/20270711
- Hsu CH; Chen MY; Cheng AL; Department of Oncology, National Taiwan University Hospital,; Taipei.
- Paclitaxel was recently recognized as an active chemotherapeutic agent for acquired immunodeficiency syndrome (AIDS)-associated Kaposi s sarcoma (KS). However, the best way to administer paclitaxel in AIDS-KS patients remains unknown. Herein, we reported an AIDS-associated KS patient whose disease progressed on the fi
- Saliva cannot destroy HIV-infected milk or semen cells [news]
- AORN J. 2000 Mar;71(3):480. Unique Identifier : AIDSLINE MED/20292037
- Moisturizing alcohol hand gels for surgical hand preparation.
- AORN J. 2000 Mar;71(3):584-7, 589-90, 592 passim. Unique Identifier : AIDSLINE MED/20200881
- Jones RD; Jampani H; Mulberry G; Rizer RL; Scientific & Regulatory Consultants, Inc., Columbia City, Ind.,; USA.
- With the use of novel formulary technology, unique moisturizing hand gels have been developed that offer significant advantages in perioperative and other health care settings. These advantages include the time-saving capabilities of a waterless formulation, the persistence and effectiveness of a surgical scrub, and t
- [Perirenal spontaneous hematoma in HIV(+)-patient in pelvic kidney]
- Arch Esp Urol. 2000 Mar;53(2):161-3. Unique Identifier : AIDSLINE MED/20262267
- Garcia Panos JM; Jimenez Leiro JF; Sampietro Crespo A; Bolano N; Olle Carreras J; Servicio de Urologia, Hospital Virgen de la Salud, Toledo,; Espana.
- OBJECTIVE: A case of spontaneous perirenal hematoma in pelvic kidney in an HIV(+) patient is described. METHODS: The literature on the etiology of spontaneous perirenal hematoma in pelvic kidney is reviewed, with special reference to the three cases reported in HIV(+) patients. RESULTS/CONCLUSION: The patient presente
- Can polymerase chain reaction help distinguish benign from malignant lymphoid aggregates in bone marrow aspirates?
- Arch Pathol Lab Med. 2000 Apr;124(4):511-5. Unique Identifier : AIDSLINE MED/20211153
- Ben-Ezra J; Hazelgrove K; Ferreira-Gonzalez A; Garrett CT; Department of Pathology, Medical College of Virginia Campus of; Virginia Commonwealth University, Richmond, VA 23298-0250, USA.
- OBJECTIVE: Although morphologic and immunologic clues are helpful in distinguishing benign from malignant lymphoid aggregates in bone marrow biopsies, there remain some cases in which it is not possible to arrive at a definitive diagnosis. Since the malignant aggregates are monoclonal B-cell proliferations, we sought
- Laboratory abnormalities in former blood donors seropositive for human T-lymphotropic virus types 1 and 2: a prospective analysis.
- Arch Pathol Lab Med. 2000 Apr;124(4):550-5. Unique Identifier : AIDSLINE MED/20211160
- Glynn SA; Murphy EL; Wright DJ; Sacher RA; Fridey J; Schreiber GB; Westat Inc, Rockville, MD 20850, USA.
- CONTEXT: The human T-lymphotropic viruses types 1 and 2 (HTLV-1 and HTLV-2) are highly prevalent among injection drug users in the United States . However, the clinical course of infection has not been well characterized. OBJECTIVE: To understand HTLV-1-and HTLV-2-associated laboratory
- Multiple crusted cutaneous plaques in a cat.
- Aust Vet J. 1999 Jun;77(6):360, 367-8. Unique Identifier : AIDSLINE MED/20272278
- Foster SF; Charles JA; Swinney GR; Malik R; Department of Veterinary Clinical Sciences, University of Sydney,; New South Wales.
- HIV postexposure prophylaxis for children and adolescents.
- Unique Identifier : AIDSLINE MED/20289497
- Babl FE; Cooper ER; Damon B; Louie T; Kharasch S; Harris JA
- HIV postexposure prophylaxis (PEP) is now a well-established part of the management of health care workers after occupational exposures to HIV. Use of PEP for adults exposed to HIV after sexual contact or injection drug use in nonoccupational settings remains controversial with limited data available. There is even le
- The occupational hazards of emergency physicians.
- Unique Identifier : AIDSLINE MED/20289499
- Dorevitch S; Forst L; Department of Emergency Medicine, Lake Forest Hospital, IL, USA.; sdorevit@uic.edu
- Emergency physicians are exposed to a variety of occupational hazards. Among these are infectious diseases, such the human immunodeficiency virus, hepatitis B and C viruses, and tuberculosis. Hepatitis G virus is transmissible but may not be a cause of illness. The likelihood of being exposed to these agents appears t
- Effects of paternal lymphocyte immunization on peripheral Th1/Th2 balance and TCR V beta and V gamma repertoire usage of patients with recurrent spontaneous abortions.
- Am J Reprod Immunol. 2000 Feb;43(2):107-15. Unique Identifier : AIDSLINE MED/20197649
- Hayakawa S; Karasaki-Suzuki M; Itoh T; Ishii M; Kanaeda T; Nagai N; Takahashi-Yamamoto N; Tochigi M; Chishima F; Fujii TK; Oyama J; Kitanaka S; Satoh K; Department of Obstetrics and Gynaecology, Nihon University School; of Medicine, Tokyo, Japan. jag06-422@nifty.ne.jp
- PROBLEM: The mechanism of immunotherapy for patients with recurrent spontaneous abortions is not well understood. In order to investigate the suppressor mechanism of paternal lymphocyte immunization, we examined peripheral blood lymphocyte subpopulations and the repertoire of T-cell receptor (TCR) gene segments. METHO
- [Nasal leishmaniasis in an HIV-positive patient]
- Acta Otorrinolaringol Esp. 2000 Mar;51(2):169-73. Unique Identifier : AIDSLINE MED/20263582
- Grasa JM; Lorente J; Crego F; Naches S; Subirana FX; Calderon JR; Pollan C; Encarnacion LF; Quesada P; Servicio de ORL, Hospital General Universitario Vall d'Hebron,; Barcelona, Espana. 32470jpg@comb.es
- Leishmania is currently one of the most clinically important protozoa in otorhinolaryngology. Mediterranean countries, including Spain , have endemic HIV and L. infantum. Dogs are the most important Leishmania reservoir. Leishmaniasis is transmitted basically by the bite of infected
- Molecular epidemiology of HIV type 1 in a rural community in southwest Uganda.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):393-401. Unique Identifier : AIDSLINE +
- Kaleebu P; Whitworth J; Hamilton L; Rutebemberwa A; Lyagoba F; Morgan D; Duffield M; Biryahwaho B; Magambo B; Oram J; Medical Research Council Programme for AIDS in Uganda/Uganda; Virus Research Institute, Entebbe. mrc@starcom.co.ug
- The molecular epidemiology of a population-based cohort in a cluster of 15 villages in southwestern Uganda was investigated by sequencing part of the p24 gag gene and performing heteroduplex mobility assays (HMAs) of the V3 region of the env gene. Sequence and HMA data, obtained fo
- Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):403-13. Unique Identifier : AIDSLINE MED/20233480
- Markert ML; Hicks CB; Bartlett JA; Harmon JL; Hale LP; Greenberg ML; Ferrari G; Ottinger J; Boeck A; Kloster AL; McLaughlin TM; Bleich KB; Ungerleider RM; Lyerly HK; Wilkinson WE; Rousseau FS; Heath-Chiozzi ME; Leonard JM; Haase AT; Shaw GM; Bucy RP; Douek DC; Koup RA; Haynes BF; Bolognesi DP; Weinhold KJ; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina 27710, USA. marke001@mc.duke.edu
- The purpose of this study was to determine whether thymic transplantation in addition to highly active antiretroviral therapy (HAART) will restore T cell function in HIV infection. Eight treatment-naive HIV-infected patients with CD4+ T cell counts of 200-500/mm3 were randomized into thymic transplantation and control
- Effect of food and pharmacokinetic variability on didanosine systemic exposure in HIV-infected children. Pediatric AIDS Clinical Trials Group Protocol 144 Study Team.
- Unique Identifier : AIDSLINE MED/20233481
- Stevens RC; Rodman JH; Yong FH; Carey V; Knupp CA; Frenkel LM
- The effect of food on didanosine bioavailability and interpatient pharmacokinetic variability was examined in children infected with human immunodeficiency virus type 1 (HIV-1). Didanosine pharmacokinetics were determined during fasting and fed conditions in HIV-infected children enrolled in the Pediatric AIDS Clinica
- Quantitative study of beta1-integrin expression and fibronectin interaction profile of T lymphocytes in vitro infected with HIV.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):423-33. Unique Identifier : AIDSLINE MED/20233482
- Leblond V; Legendre C; Gras G; Dereuddre-Bosquet N; Lafuma C; Dormont D; CEA, Service de Neurovirologie, DSV/DRM, CRSSA, IPSC, Fontenay; aux Roses, France.
- Cell-extracellular matrix interactions, regulated in part by beta1-integrins, play a key role in the recirculation of T lymphocytes and tissue infiltration in inflammatory and immune responses. HIV infection may affect CD4+ T cell adhesion, and the trafficking and migration of these cells, which are crucial for foreig
- Mycobacterium avium induces HIV upregulation through mechanisms independent of cytokine induction.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):435-40. Unique Identifier : AIDSLINE MED/20233483
- Ghassemi M; Asadi FK; Andersen BR; Novak RM; Department of Medicine, University of Illinois, Chicago 60612,; USA. Ghassemi@uic.edu
- Mycobacterium avium complex (MAC) can induce upregulation of HIV. To investigate the underlying mechanisms, the effect of MAC-induced cytokines on HIV replication was first studied. Semiquantitative RT-PCR, followed by Northern blot analysis, revealed that mRNA encoding IL-6 and TNF-alpha was induced by MAC. However,
- nef/long terminal repeat quasispecies from HIV type 1-infected Mexican patients with different progression patterns and their pathogenesis in hu-PBL-SCID mice.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):441-52. Unique Identifier : AIDSLINE MED/20233484
- Gomez-Roman VR; Vazquez JA; del Carmen Basualdo M; Estrada FJ; Ramos-Kuri M; Soler C; Unidad de Investigacion en Retrovirus Humanos, Instituto de; Investigaciones Biomedicas, Universidad Nacional Autonoma de; Mexico, DF Mexico.
- To examine the genetic features of the long terminal repeat (LTR) derived from six HIV-1-infected individuals enrolled in the Mexico City Cohort, we cloned and sequenced a 505-bp fragment of the proviral LTR from their peripheral blood mononuclear cells (PBMCs). All patients harbored HIV-1 LTR quasispecies correspondi
- Human immunodeficiency virus type 1 can infect human retinal pigment epithelial cells in culture and alter the ability of the cells to phagocytose rod outer segment membranes.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):453-63. Unique Identifier : AIDSLINE MED/20233485
- Canki M; Sparrow JR; Chao W; Potash MJ; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, Columbia University, New York, New York 10019, USA.
- Human immunodeficiency virus type 1 (HIV-1) has been found in the vitreous of persons with AIDS. Here we investigated the susceptibility of human retinal pigment epithelial (RPE) cells to HIV-1 infection in culture and the effects of HIV-1 on the phagocytic function of the RPE. We found that 10 of 11 populations of RP
- Construction of chimeric simian and human immunodeficiency viruses that produce interleukin 12.
- Unique Identifier : AIDSLINE MED/20233486
- Kuwata T; Miura T; Haga T; Kozyrev I; Hayami M
- Chimeric simian and human immunodeficiency viruses (SHIVs) are useful for evaluating vaccine candidates against HIV-1 and for investigating the pathogenesis of HIV-1 in vivo. In addition, SHIVs are candidates for a vaccine against HIV-1 because attenuated SHIVs can induce long-lasting anti-HIV-1 Env humoral and cell-m
- HERV-IP-T47D, a novel type C-related human endogenous retroviral sequence derived from T47D particles.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):471-80. Unique Identifier : AIDSLINE GENBANK/AF087913
- Seifarth W; Baust C; Schon U; Reichert A; Hehlmann R; Leib-Mosch C; Medical Clinic III, Faculty of Clinical Medicine Mannheim,; University of Heidelberg, Germany. seifarth@rumms.uni-manheim.de
- A new type C retrovirus-related endogenous pol sequence (ERV-FTD) found to be occasionally copackaged in retrovirus-like particles released by the human mammary carcinoma cell line T47D was used to screen a human genomic library (Seifarth W, Skladny H, Krieg-Schneider F, Reichert A, Hehlmann R, and Leib-Mosch C: J Vir
- Mice transgenic for monocyte-tropic HIV type 1 produce infectious virus and display plasma viremia: a new in vivo system for studying the postintegration phase of HIV replication.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):481-92. Unique Identifier : AIDSLINE MED/20233488
- Browning Paul J; Wang EJ; Pettoello-Mantovani M; Raker C; Yurasov S; Goldstein MM; Horner JW; Chan J; Goldstein H; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, New York 10461, USA.
- To generate an in vivo system for investigating the postintegration phase of HIV-1 replication, mouse lines transgenic for a full-length infectious proviral clone of a monocyte-tropic HIV-1 isolate, HIV-1JR-CSF, were constructed. Leukocytes from two independent JR-CSF transgenic mouse lines produced HIV-1 that infecte
- Identification of HIV type 1 intersubtype recombinants in South Africa using env and gag heteroduplex mobility assays.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):493-7. Unique Identifier : AIDSLINE GENBANK/AF159878
- Bredell H; Hunt G; Morgan B; Tiemessen CT; Martin DJ; Morris L; AIDS Virus Research Unit, National Institute for Virology,; Johannesburg, South Africa.
- Subtype-specific sequence variation of the HIV type 1 long terminal repeat and primer-binding site.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):499-504. Unique Identifier : AIDSLINE +
- De Baar MP; De Ronde A; Berkhout B; Cornelissen M; Van Der Horn KH; Van Der Schoot AM; De Wolf F; Lukashov VV; Goudsmit J; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands. m.p.debaar@amc.uva.nl
- We studied sequence differences in regulatory elements of the long terminal repeat (LTR) and primer-binding site (PBS) among various human immunodeficiency virus type 1 (HIV-1) subtypes. Phylogenetic sequence analysis of a fragment of 729 base pairs (bp) covering the Gag-coding region for half of p24 and all of p17 re
- Recombinant human immunodeficiency viruses type 1 circulating in Spain.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):505-11. Unique Identifier : AIDSLINE +
- Holguin A; Rodes B; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- The protease, reverse transcriptase (RT), and envelope (env) genes of human immunodeficiency virus type 1 (HIV-1) clinical isolates from 13 immigrants (mainly of African origin) living in Spain were examined. Phylogenetic analyses were performed, taking as reference a panel of 25 HI
- Genetic subtypes of HIV type 1 in Hungary.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):513-6. Unique Identifier : AIDSLINE GENBANK/AJ245472
- Mezei M; Balog K; Takacs M; Toth G; Gyuris A; Segesdi J; Bakos A; Vodros D; Banhegyi D; Berencsi G; Minarovits J; Microbiological Research Group, National Center for Epidemiology,; Budapest, Hungary.
- We examined the diversity of HIV-1 subtypes in 11 adults from Hungary , using the heteroduplex mobility assay (HMA) and DNA sequencing. HMA results showed that HIV-1 gp120 sequences from 10 patients were of subtype B, whereas 1 patie
- Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):517-28. Unique Identifier : AIDSLINE MED/20236900
- Balzarini J; De Clercq E; Carbonez A; Burt V; Kleim JP; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. ian.balzarini@rega.kuleuven.ac.be
- The novel quinoxaline GW420867X has been combined with a variety of nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1(IIIB)-infected CEM cell cultures. Whereas the antiviral efficacy of combinations of GW420867X with the NRTIs lamivudine (
- Baseline HIV type 1 genotypic resistance to a newly added nucleoside analog is predictive of virologic failure of the new therapy.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):529-37. Unique Identifier : AIDSLINE MED/20236901
- Van Vaerenbergh K; Van Laethem K; Van Wijngaerden E; Schmit JC; Schneider F; Ruiz L; Clotet B; Verhofstede C; Van Wanzeele F; Muyldermans G; Simons P; Stuyver L; Hermans P; Evans C; De Clercq E; Desmyter J; Vandamme AM; Rega Institute and University Hospitals, Katholieke Universiteit; Leuven, Belgium.
- We evaluated the predictive value of baseline HIV-1 genotypic resistance mutations for failure of a nucleoside reverse transcriptase inhibitor (NRTI) containing therapy. The change in therapy of 88 HIV-1-infected patients was analyzed retrospectively, relating the genotypic resistance profile at baseline to the evolut
- Enhancement of HIV type 1 antigen-specific CD4+ T cell memory in subjects with chronic HIV type 1 infection receiving an HIV type 1 immunogen.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):539-47. Unique Identifier : AIDSLINE MED/20236902
- Maino VC; Suni MA; Wormsley SB; Carlo DJ; Wallace MR; Moss RB; Becton Dickinson Immunocytometry Systems, San Jose, California; 95131, USA.
- We examined HIV-1 specific memory helper T immune responses in chronically HIV-infected subjects who received an immune-based therapy (HIV-1 immunogen, Remune). Subjects in this study exhibited significant increases (p
- Expression of the novel T cell activation molecule hpH4 in HIV-infected patients: correlation with disease status.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):549-57. Unique Identifier : AIDSLINE MED/20236903
- Lucia MB; Buonfiglio D; Bottarel F; Bensi T; Rutella S; Rumi C; Ortona L; Janeway CA Jr; Cauda R; Dianzani U; Department of Infectious Diseases, Catholic University of Rome,; Italy.
- We have described hpH4, a surface glycoprotein selectively expressed by activated T cells and mature thymocytes and displaying weak lateral association with CD4. The hpH4 expression pattern and biochemical features, together with analysis of its tryptic digest by peptide mass searching using MALDI-MS, suggested that i
- Decreased HIV-associated T cell apoptosis by HIV protease inhibitors.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):559-67. Unique Identifier : AIDSLINE MED/20236904
- Phenix BN; Angel JB; Mandy F; Kravcik S; Parato K; Chambers KA; Gallicano K; Hawley-Foss N; Cassol S; Cameron DW; Badley AD; Department of Biochemistry, Microbiology, and Immunology,; University of Ottawa, Ontario, Canada.
- Antiretroviral treatment of patients infected with HIV results in improvements in CD4+ T cell number. Emerging evidence suggests that some of the improvements in CD4+ T cell number that occur in response to protease inhibitor (PI) therapy may not be accounted for solely by enhanced viral suppression, implying that PI
- Molecular characterization of feline interleukin 16: chemotactic activity and effect on feline immunodeficiency virus infection and/or replication.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):569-75. Unique Identifier : AIDSLINE GENBANK/AF003701
- Leutenegger CM; Huder JB; Mislin CN; Lahrtz F; Hofmann-Lehmann R; Pedersen NC; Lutz H; Department of Internal Veterinary Medicine, University of Zurich,; Switzerland. cmleutenegger@ucdavis.edu
- Interleukin 16 (IL-16) has been shown to diminish HIV and SIV replication through inhibition of HIV and SIV mRNA transcription. To evaluate its role in the FIV cat model, we cloned and expressed feline IL-16 and determined its ability to induce chemotaxis as well as to inhibit FIV replication in cultured PBMCs. Sequen
- Construction of an SIV/HIV type 1 chimeric virus with the human interleukin 6 gene and its production of interleukin 6 in monkey and human cells.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):577-82. Unique Identifier : AIDSLINE MED/20236906
- Haga T; Kuwata T; Kozyrev I; Kwofie TB; Hayami M; Miura T; Laboratory of Viral Pathogenesis, Institute for Virus Research,; Kyoto University, Japan.
- The switch from a Th1- to a Th2-type cytokine response is reported to be involved in human immunodeficiency virus (HIV) disease progression. To study the effect of IL-6, one of the Th2-type cytokines, on AIDS pathogenesis, we constructed an SIV/HIV-1 chimeric virus (SHIV) having the human IL-6 gene (SHIV-IL6) SHIV-IL6
- IgG subclass distribution in serum and various mucosal fluids of HIV type 1-infected subjects.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):583-94. Unique Identifier : AIDSLINE MED/20236907
- Raux M; Finkielsztejn L; Salmon-Ceron D; Bouchez H; Excler JL; Dulioust E; Grouin JM; Sicard D; Blondeau C; Aventis Pasteur, Val de Reuil, France. Maurice.Raux@aventis.com
- We measured total IgG1, IgG2, IgG3, and IgG4 concentrations by ELISA in serum (S), total saliva (TS), cervicovaginal secretions (CVS), seminal secretions (SPE), and rectal secretions (RS) from either CDC II/III HIV-1-infected subjects or healthy volunteers. Human serum albumin was measured in parallel to calculate the
- False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigens.
- Unique Identifier : AIDSLINE MED/20236908 P
- Jackson S; Prince S; Kulhavy R; Mestecky J
- Identification of all HIV type 1 group M subtypes in Senegal, a country with low and stable seroprevalence.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):603-9. Unique Identifier : AIDSLINE +
- Toure-Kane C; Montavon C; Faye MA; Gueye PM; Sow PS; Ndoye I; Gaye-Diallo A; Delaporte E; Peeters M; Mboup S; Virology, Laboratory, Hopital Le Dantec, Dakar, Senegal.
- A total of 343 HIV-1-positive samples obtained between June 1996 and March 1999 was genetically characterized in the envelope region by HMA and/or sequencing. The env subtype distribution was as follows: 290 (84.6%) A, 22 (6.5%) B, 16 (4.7%) C, 8 (2.5%) D, 1 (0.03%) E, 1 (0.03%) F1, 4 (1.2%) G, and 1 (0.03%) H. For 77
- Large-scale ex vivo expansion of primary T lymphocytes in late-stage AIDS patients [letter]
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):611-2. Unique Identifier : AIDSLINE MED/20236910
- Shimizu N; Sekine T; Itoh K; Nakamura T; Iwamoto A; Satoh Y; Yamamoto K
- Treatment of HIV-associated invasive anal cancer with combined chemoradiation.
- Eur J Cancer. 2000 Apr;36(6):754-8. Unique Identifier : AIDSLINE MED/20227632
- Cleator S; Fife K; Nelson M; Gazzard B; Phillips R; Bower M; Department of Radiotherapy, Charing Cross Hospital, Fulham Palace; Road, London, UK.
- There is an increased frequency of invasive anal cancer in HIV-seropositive men. Early treatment strategies in this patient group employed reduced dosages of chemotherapy or radiotherapy alone to reduce toxicity. Since 1989 we have used combined modality treatment consisting of chemotherapy 5-fluorouracil (5-FU) and m
- Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes.
- Br J Haematol. 2000 Mar;108(3):488-95. Unique Identifier : AIDSLINE MED/20223061
- Durig J; Giese A; Schulz-Schaeffer W; Rosenthal C; Schmucker U; Bieschke J; Duhrsen U; Kretzschmar HA; Department of Haematology, University Hospital Essen, Germany.
- The cellular isoform of the prion protein (PrPC) is a cell surface glycoprotein that has recently been shown to play a role in haemopoietic cell activation and proliferation. We have characterized the constitutive expression of PrPC on human peripheral blood (pB) cell populations, using PrP-specific antibodies in a mu
- T cells and fibroblasts in affected extraocular muscles in early and late thyroid associated ophthalmopathy [see comments]
- Unique Identifier : AIDSLINE MED/20245340 P
- Pappa A; Lawson JM; Calder V; Fells P
- Optic neuropathy as the presenting feature of HIV infection: recovery of vision with highly active antiretroviral therapy [letter]
- Unique Identifier : AIDSLINE MED/20300015
- Goldsmith P; Jones RE; Ozuzu GE; Richardson J; Ong EL
- A delay-differential equation model of HIV infection of CD4(+) T-cells.
- Math Biosci. 2000 May;165(1):27-39. Unique Identifier : AIDSLINE MED/20265876
- Culshaw RV; Ruan S; Department of Mathematics and Statistics, Dalhousie University,; Halifax, Nova Scotia, Canada. rebecca@mscs.dal.ca
- A.S. Perelson, D.E. Kirschner and R. De Boer (Math. Biosci. 114 (1993) 81) proposed an ODE model of cell-free viral spread of human immunodeficiency virus (HIV) in a well-mixed compartment such as the bloodstream. Their model consists of four components: uninfected healthy CD4(+) T-cells, latently infected CD4(+) T-ce
- Viral hepatitis C.
- J Assoc Acad Minor Phys. 1998;9(4):59-64. Unique Identifier : AIDSLINE MED/20285749
- Leevy CB; Zierer KG; Leevy CM; UMDNJ-New Jersey Medical School Liver Center, Newark 07103, USA.
- Identification of a cDNA clone and the genome of hepatitis C virus in 1988-1989 allowed the development of clinical tests that are now used to detect and quantify hepatitis C virus. This has largely eliminated post-transfusion hepatitis C virus infection; however, the overall incidence of chronic hepatitis C and its c
- Esophageal candidoma in a patient with acquired immunodeficiency syndrome.
- J Assoc Acad Minor Phys. 1998;9(4):69-71. Unique Identifier : AIDSLINE MED/20285751
- Bhalodia MV; Vega KJ; DaCosta J; Trotman BW; Department of Medicine, UMDNJ-New Jersey Medical School and; University Hospital, Newark 07103-2714, USA.
- Oral thrush and esophagitis caused by Candida are common in patients infected with the human immunodeficiency virus. We present the case of a 33-year-old man with acquired immunodeficiency syndrome who developed dysphagia during a hospitalization for pneumonia. Signs and sympto
- The ethics of unlinked anonymous testing. Surveys provide essential information [letter]
- BMJ. 2000 May 6;320(7244):1275. Unique Identifier : AIDSLINE MED/20259342
- Nicoll A; Gill N; Goldberg D; Peckham C
- The ethics of unlinked anonymous testing. Testing need not stop [letter]
- BMJ. 2000 May 6;320(7244):1275-6. Unique Identifier : AIDSLINE MED/20303705
- Foex BA
- The possible role of interleukin-16 in the low incidence of HIV infection in patients with systemic lupus erythematosus [letter]
- Lupus. 2000;9(2):155-6. Unique Identifier : AIDSLINE MED/20246697
- Sekigawa I; Lee S; Kaneko H; Iida N; Hashimoto H; Hirose S; Kaneko Y
- Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.
- Pharmacogenetics. 2000 Mar;10(2):171-82. Unique Identifier : AIDSLINE MED/20222642
- O'Neil WM; Drobitch RK; MacArthur RD; Farrough MJ; Doll MA; Fretland AJ; Hein DW; Crane LR; Svensson CK; Department of Pharmaceutical Sciences, Wayne State University,; Detroit, Michigan 48202-3489, USA.
- The acetylator phenotype and genotype of AIDS patients, with and without an acute illness, was compared with that of healthy control subjects (30 per group). Two probe drugs, caffeine and dapsone, were used to determine the phenotype in the acutely ill cohort. Polymerase chain reaction amplification and restriction fr
- AIDS and HIV infection in the United Kingdom: monthly report.
- Commun Dis Rep CDR Wkly. 2000 Apr 28;10(17):157-60. Unique Identifier : AIDSLINE MED/20272628
- Predicting the outcome of therapy for pulmonary tuberculosis.
- Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1076-80. Unique Identifier : AIDSLINE MED/20227905
- Wallis RS; Perkins MD; Phillips M; Joloba M; Namale A; Johnson JL; Whalen CC; Teixeira L; Demchuk B; Dietze R; Mugerwa RD; Eisenach K; Ellner JJ; Case Western Reserve University, Cleveland, Ohio 44106, USA.; rsw2@po.cwru.edu
- Patients vary considerably in their response to treatment of pulmonary tuberculosis. Although several studies have indicated that adverse outcomes are more likely in those patients with delayed sputum sterilization, few tools are available to identify those patients prospectively. In this study, multivariate models we
- A new preadmission staging system for predicting inpatient mortality from HIV-associated Pneumocystis carinii pneumonia in the early highly active antiretroviral therapy (HAART) era.
- Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1081-6. Unique Identifier : AIDSLINE MED/20227906
- Arozullah AM; Yarnold PR; Weinstein RA; Nwadiaro N; McIlraith TB; Chmiel JS; Sipler AM; Chan C; Goetz MB; Schwartz DN; Bennett CL; Brockton/West Roxbury VA Medical Center, West Roxbury,; Massachusetts, USA.
- A common severe complication of human immunodeficiency virus (HIV) infection has been Pneumocystis carinii pneumonia (PCP). Recently, with increasing use of PCP prophylaxis and multidrug antiretroviral therapy, the clinical manifestations of HIV infection have changed dramatically and the predictors of inpatient morta
- Airway inflammation driven by antigen-specific resident lung CD4(+) T cells in alphabeta-T cell receptor transgenic mice.
- Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1340-8. Unique Identifier : AIDSLINE MED/20227944
- Knott PG; Gater PR; Bertrand CP; Inflammatory Diseases Unit, Roche Bioscience, Palo Alto,; California 94304, USA.
- CD4(+) T cells are thought to play a major role in the initiation and perpetuation of T helper cell, type 2 (Th2)-like allergic airway inflammation. However, it is not clear whether activation of resident antigen-specific CD4(+) T cells is in itself sufficient to induce such a phenotype. Using ovalbumin (OVA)-specific
- Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
- Brain Res. 2000 Apr 7;861(1):105-16. Unique Identifier : AIDSLINE MED/20216722
- Milligan ED; Mehmert KK; Hinde JL; Harvey LO; Martin D; Tracey KJ; Maier SF; Watkins LR; Department of Psychology, University of Colorado at Boulder,; Campus Box 345, Boulder, CO 80309-0345, USA.; emilligan@clipr.colorado.edu
- Astrocytes and microglia in the spinal cord have recently been reported to contribute to the development of peripheral inflammation-induced exaggerated pain states. Both lowering of thermal pain threshold (thermal hyperalgesia) and lowering of response threshold to light tactile stimuli (mechanical allodynia) have bee
- Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
- Brain Res. 2000 Apr 7;861(1):8-15. Unique Identifier : AIDSLINE MED/20216712
- Pugh CR; Johnson JD; Martin D; Rudy JW; Maier SF; Watkins LR; Department of Psychology, University of Colorado, Boulder, CO; 80309, USA. rachal@psych.colorado.edu
- Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea
- The slime loosener strikes again! [comment]
- Unique Identifier : AIDSLINE MED/20220774
- Luft FC; Franz-Volhard-Klinik, Humboldt University of Berlin, Berlin-Buch,; Germany. luft@fvk-berlin.de
- Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials [see comments]
- Unique Identifier : AIDSLINE MED/20220780
- Breitkreutz R; Pittack N; Nebe CT; Schuster D; Brust J; Beichert M; Hack V; Daniel V; Edler L; Droge W
- To determine the therapeutic effect of sulfur amino acid supplementation in HIV infection we randomized 40 patients with antiretroviral therapy (ART; study 1) and 29 patients without ART (study 2) to treatment for 7 months with N-acetyl-cysteine or placebo at an individually adjusted dose according to a defined scheme
- Interaction between indinavir and St. John's wort reported [news]
- Am J Health Syst Pharm. 2000 Apr 1;57(7):625-6. Unique Identifier : AIDSLINE MED/20229298
- Miller JL
- 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine.
- Gene Ther. 2000 Apr;7(8):694-702. Unique Identifier : AIDSLINE MED/20262159
- Arai H; Xin KQ; Hamajima K; Lu Y; Watabe S; Takahashi T; Toda S; Okuda K; Kudoh I; Suzuki M; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, Japan.
- From a series of preclinical studies and animal experiments, we have been able to demonstrate that DNA vaccines are a promising tool in strategies for protecting hosts from a variety of infectious diseases. Since the promoter activity of the human cytomegalovirus immediate-early pr
- Altered expression of natural killer cell inhibitory receptors (KIRs) on T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients.
- Sarcoidosis Vasc Diffuse Lung Dis. 2000 Mar;17(1):54-9. Unique Identifier : AIDSLINE MED/20210356
- Mizuki M; Eklund A; Grunewald J; Health Care Center, Oita Medical University, Japan.
- BACKGROUND AND AIM OF THE WORK: The role for natural killer cell inhibitory receptors (KIRs) on T cells is not fully understood, but signalling through KIRs on T cells may inhibit T cell receptor mediated activation, and KIR expression has been suggested to be one mechanism of controlling T cell mediated immune respon
- Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas.
- Unique Identifier : AIDSLINE MED/20237466
- Zhuang SM; Wiseman RW; Soderkvist P
- The pRb pathway plays a key role in controlling the G1/S transition in cell cycle progression. Aberrations of various components of the pRb pathway, such as retinoblastoma protein and its upstream actors including cyclin D1, cyclin dependence kinase-4 and p16/p15 cyclin dependent kinase inhibitors, have
- Increased burn-induced immunosuppression in lipopolysaccharide-resistant mice.
- Cell Immunol. 2000 Mar 15;200(2):65-75. Unique Identifier : AIDSLINE MED/20218893
- Jobin N; Garrel DR; Bernier J; Centre hospitalier de l'Universite de Montreal; (CHUM)-Hotel-Dieu, Centre des grands brules, Montreal, PQ,; Canada.
- Severe burns induce a state of immunosuppression, and the inflammatory response after burn injury may play a role in this phenomenon. This study examined the effect of the inflammatory response to endotoxin on burn-induced immunosuppression and oxidative stress. An endotoxin-resistant mouse strain (C3H/HeJ) and a norm
- The autoimmune accelerating yaa mutation does not accelerate murine AIDS.
- Cell Immunol. 2000 Mar 15;200(2):76-80. Unique Identifier : AIDSLINE MED/20218894
- Hugin AW; Fossati-Jimack L; Izui S; Department of Dermatology, University Hospital, Geneva,; Switzerland.
- Murine acquired immunodeficiency syndrome (MAIDS) is characterized by lymphoproliferation, polyclonal B cell activation resulting in the production of autoantibodies, and a progressive immunodeficiency. These are all hallmarks of some autoimmune diseases. Yaa is a Y-chromosome-linked gene that accelerates autoimmune d
- [General practice patterns in hepatitis C virus mass screening in the Lyons region]
- Sante Publique. 1999 Dec;11(4):513-25. Unique Identifier : AIDSLINE MED/20258512
- Sahajian F; Caillat-Vallet E; Bailly F; Excler G; Trepo C; Fabry J; Sepetjan M; ADHEC, Laboratoire d'Epidemiologie et de Sante Publique,; Faculte de medecine Domaine Rockefeller, Lyon, France.
- A study on the screening practices for hepatitis C was carried out among a sample of 786 general practitioners in the Lyon region. The sample comprised three groups: 272 doctors who had participated in a study of this screening, 242 doctors who had not responded to the request for participation, and 272 doctors who ha
- Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine.
- Toxicol Sci. 2000 Apr;54(2):322-9. Unique Identifier : AIDSLINE MED/20234847
- Meng Q; Su T; Olivero OA; Poirier MC; Shi X; Ding X; Walker VE; Wadsworth Center, New York State Department of Health, Albany; 12201-0509, USA.
- 3 -Azido-3 -deoxythymidine ( AZT ), a thymidine analogue widely used in the treatment of AIDS patients and for prevention of the onset of AIDS in HIV-seropositive individuals, causes tumors in mice exposed as adults or in utero. The purpose of this stud
- The effects of alternative treatments for HIV disease on recommended pharmacological regimens.
- Int J Antimicrob Agents. 2000 Feb;13(4):281-5. Unique Identifier : AIDSLINE MED/20216018
- Manfredi R; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, S. Orsola Hospital, Italy.
- The use of alternative treatments for HIV disease was assessed before and after the introduction of highly active antiretroviral therapy (HAART) by the use of a standardised questionnaire. These data were related to epidemiological, clinical and laboratory parameters and compliance levels to recommended antiretroviral
- An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
- Acta Crystallogr D Biol Crystallogr. 2000 Apr;56 ( Pt 4):381-8. Unique Identifier : AIDSLINE MED/20207109
- Munshi S; Chen Z; Yan Y; Li Y; Olsen DB; Schock HB; Galvin BB; Dorsey B; Kuo LC; Department of Antiviral Research, Merck Research Laboratories,; West Point, PA 19486, USA. sanjeev_munshi@merck.com
- Structures of the complexes of HIV protease inhibitor L--756,423 with the HIV-1 wild-type protease and of the inhibitors Indinavir , L-739,622 and Saquinavir with the mutant protease (9X) containing nine point mutations (Leu10Val, Lys20Met, Leu24Ile, S
- Oral supplements as adjunctive treatment to nutritional counseling in malnourished HIV-infected patients: randomized controlled trial.
- Clin Nutr. 1999 Dec;18(6):371-4. Unique Identifier : AIDSLINE MED/20102920
- Schwenk A; Steuck H; Kremer G; Klinik I fur Innere Medizin, University of Cologne, Cologne,; Germany.
- AIMS:To compare nutritional counseling with and without oral supplements in HIV-infected patients with recent weight loss. DESIGN: Randomized non-blinded controlled trial, stratified for change in antiretroviral treatment at baseline. PATIENTS: HIV-infected patients with recent weight loss (> 5% of total, and >3% in t
- Thiamin deficiency in HIV-positive patients: evaluation by erythrocyte transketolase activity and thiamin pyrophosphate effect.
- Clin Nutr. 1999 Dec;18(6):375-8. Unique Identifier : AIDSLINE MED/20102921
- Muri RM; Von Overbeck J; Furrer J; Ballmer PE; Departments of Neurology, University of Bern, Bern, Switzerland.
- BACKGROUND AND AIMS: The aim of the study was to determine the thiamin status in HIV-positive patients. METHODS: Measurement of erythrocyte transketolase activity (ETK) and thiaminpyrophosphate (TPP) effect in 55 consecutive HIV-positive patients of a specialized outpatient clinic were grouped into five groups accordi
- An analysis of the catalytic cycle of HIV-1 reverse transcriptase: opportunities for chemotherapeutic intervention based on enzyme inhibition.
- Curr Pharm Des. 2000 Mar;6(5):547-67. Unique Identifier : AIDSLINE MED/20251319
- Furman PA; Painter GR; Anderson KS; Triangle Pharmaceuticals, 4 University Place, 4611 University; Drive, Durham, NC 27707, USA.
- This review describes each of the steps in the HIV-1 reverse transcriptase catalytic cycle and evaluates each of these steps as a potential point of inhibition of the enzyme and consequently viral replication. To date, two classes of approved drugs act on the reverse transcriptase. They are: (1) the nucleoside reverse
- Anti-HIV-1 integrase drugs: how far from the shelf?
- Curr Pharm Des. 2000 Mar;6(5):569-84. Unique Identifier : AIDSLINE MED/20251320
- Pani A; Marongiu ME; Dipartimento di Biologia Sperimentale, Sezione di Microbiologia,; Universita' degli Studi di Cagliari, Italy.
- Chemotherapy of HIV-1 infection/AIDS currently employs inhibitors of two products of the viral pol gene, the reverse transcriptase and protease enzymes. However, a third product of the pol gene is essential for retroviral multiplication, the integrase. As no cellular homologue of HIV integrase has been described, pote
- Design of anti-HIV compounds: from nucleoside to nucleoside 5'-triphosphate analogs. Problems and perspectives.
- Curr Pharm Des. 2000 Mar;6(5):585-98. Unique Identifier : AIDSLINE MED/20251321
- Kukhanova M; Krayevsky A; Prusoff W; Cheng YC; Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, 32 Vavilov St, Moscow, 117984. kukhan@medmail.com
- To date, human immunodeficiency virus infection remains incurable although a variety of antiviral agents have been identified and characterized. Even though nucleoside analogs have been the most successful prodrugs, there remains the need to develop new compounds that exhibit a more favorable toxicity profile, less su
- The role of vascular endothelial growth factor (VEGF) in AIDS-related Kaposi's sarcoma.
- Oncologist. 2000;5 Suppl 1:28-31. Unique Identifier : AIDSLINE MED/20264296
- Arasteh K; Hannah A; Auguste-Viktoria-Krankenhaus, Berlin, Germany.; arasteh@avk.b.shuttle.de
- Kaposi s sarcoma (KS) is the most common neoplasm associated with human immunodeficiency virus-1 (HIV-1) infection. KS involves the skin and mucous membranes as well as other organs and can lead to tumor-associated edema and ulcerations. Despite therapy with highly active antiviral agents, most patients with HIV-1-rel
- Surgeons who test positive for hepatitis C should not be transferred to low risk duties.
- Rev Med Virol. 2000 Mar-Apr;10(2):79-82. Unique Identifier : AIDSLINE MED/20180467
- Cockcroft A; Department of Occupational Health, Royal Free Hampstead NHS; Trust, London, UK.
- Current UK guidelines allow surgeons who are antibody-positive for hepatitis C virus (HCV) to continue performing exposure-prone procedures (EPPs) unless they have been shown to transmit HCV to a patient. Given the low rate of recognised transmission from surgeon to patient, this recommendation is probably reasonable
- Endoneurial vasculitis and tubuloreticular inclusions in peripheral nerve biopsy.
- Clin Neuropathol. 2000 Mar-Apr;19(2):70-6. Unique Identifier : AIDSLINE MED/20210858
- Midroni G; Cohen SM; Bilbao JM; Division of Neurology, St. Michael's Hospital, University of; Toronto, Ontario, Canada.
- We describe 3 patients in whom nerve biopsy revealed endothelial tubuloreticular inclusions in association with peripheral nerve endoneurial vasculitis. Two of the patients had systemic lupus erythematosus (SLE), while the third was HIV-positive. Review of our biopsy material featuring the much more common finding of
- [The recent advances of HAM/TSP research]
- Rinsho Shinkeigaku. 1999 Dec;39(12):1200-2. Unique Identifier : AIDSLINE MED/20251674
- Osame M; 3rd Department of Internal Medicine, Faculty of Medicine,; Kagoshima University.
- The ninth international conference on HTLVs and related disorders was held on April 5-9, 1999 at Kagoshima, Japan under the conference chairperson, Dr. Mitsuhiro Osame. In this meeting, world-wide epidemiological data on HTLV-I carriers, ATL patients, and HAM/TSP patients were summa
- T(H)1 to T(H)2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linked immunosorbent assay under nonstimulated conditions.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):287-94. Unique Identifier : AIDSLINE MED/20294739
- Altfeld M; Addo MM; Kreuzer KA; Rockstroh JK; Dumoulin FL; Schliefer K; Leifeld L; Sauerbruch T; Spengler U; Department of Internal Medicine I, University of Bonn, Germany.; MALTFELD@partners.org
- BACKGROUND: Dysregulation of cytokines has been implicated in the pathogenesis of HIV infection. Therefore, we determined tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-4, IL-10, and interferon-gamma (IFN-gamma) mRNA and serum levels in HIV-infected patients under nonstimulated conditions. M
- Depressive symptoms decline among persons on HIV protease inhibitors.
- Unique Identifier : AIDSLINE MED/20294740
- Low-Beer S; Chan K; Yip B; Wood E; Montaner JS; O'Shaughnessy MV; Hogg RS
- OBJECTIVE: To ascertain whether initiation of protease inhibitors was associated with a change in depressive symptoms among persons
- Impact of zidovudine-based triple combination therapy on an AIDS drug assistance program.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):302-13. Unique Identifier : AIDSLINE MED/20294741
- Mauskopf JA; Tolson JM; Simpson KN; Pham SV; Albright J; Research Triangle Institute, Research Triangle Park, North; Carolina, USA.
- A static deterministic model was used to estimate the effect of the shift to a triple combination therapeutic standard on the annual AIDS Drug Assistance Program (ADAP) budget, total medical care expenditures, and population health outcomes for New York (NY) state ADAP enrollees. The model used opportunistic disease i
- Dissociation of immunologic and virologic responses to highly active antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):314-20. Unique Identifier : AIDSLINE MED/20294742
- Fessel WJ; Krowka JF; Sheppard HW; Gesner M; Tongson S; Weinstein S; Ascher M; Kwok S; Christopherson C; Kaiser Permanente Medical Center, San Francisco, California; 94115, USA.
- OBJECTIVE: Immunologic markers, levels of HIV DNA, and infectious HIV were compared in partial responders (PR) to HAART who had high plasma HIV RNA levels but stable or increasing levels of CD4+ peripheral blood mononuclear cells (PBMC), and patients with complete failure (CF) who had very low or decreasing levels of
- Improved antioxidant status among HIV-infected injecting drug users on potent antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):321-6. Unique Identifier : AIDSLINE MED/20294743
- Tang AM; Smit E; Semba RD; Shah N; Lyles CM; Li D; Vlahov D; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University', Baltimore, Maryland, USA.
- Low serum antioxidant levels in HIV-infected people have been attributed to altered metabolism associated with excess oxidative stress. We conducted a study to examine serum antioxidant levels in 175 HIV-positive and 210 HIV-negative injecting drug users (IDUs) in Baltimore, Maryland. At the time of data collection, 3
- The HIV epidemic in the Amazon Basin is driven by prototypic and recombinant HIV-1 subtypes B and F.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):327-31. Unique Identifier : AIDSLINE GENBANK/AF076316
- Vicente AC; Otsuki K; Silva NB; Castilho MC; Barros FS; Pieniazek D; Hu D; Rayfield MA; Bretas G; Tanuri A; Genetics Department, Instituto Oswaldo Cruz, Rio de Janeiro,; Brazil.
- This paper describes genetic subtypes of HIV-1 found in blood samples from 31 HIV-1-infected people who visited the Counseling and Testing AIDS Center of Instituto de Medicina Tropical in Manaus, Brazil . Manaus, the main city in Brazil s Amazon Basin, is also the closest urban conn
- Mortality of HIV-positive and HIV-negative heroin abusers as a function of duration of injecting drug use.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):332-8. Unique Identifier : AIDSLINE MED/20294745
- Muga R; Roca J; Egea JM; Tor J; Sirera G; Rey-Joly C; Munoz A; Infectious Disease Unit, Hospital Universitario Germans Trias i; Pujol, Barcelona, Spain. rmuga@ns.hugtip.scs.es
- OBJECTIVE: To determine the incidence of mortality of injecting drug users as a function of the duration of injecting drugs and HIV status, and to assess how these effects vary according to age at initiation and calendar period (before and after 1992). METHODS AND DESIGN: Cohort of 376 intravenous heroin users admitte
- Repeat screening for HIV: when to test and why.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):339-45. Unique Identifier : AIDSLINE MED/20294746
- Kaplan EH; Satten GA; Management Sciences and Public Health, Yale School of Management,; New Haven, Connecticut, 06520-8200, USA. edward.kaplan@yale.edu
- This paper presents models for repeat HIV screening under conditions of constant low HIV incidence. The models reveal a direct link between the prevalence of undetected HIV infection and the screening interval between repeat HIV tests. We show how to select screening intervals that either achieve a given HIV prevalenc
- Identifying human herpesvirus 8 infection: performance characteristics of serologic assays.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):346-54. Unique Identifier : AIDSLINE MED/20294747
- Engels EA; Whitby D; Goebel PB; Stossel A; Waters D; Pintus A; Contu L; Biggar RJ; Goedert JJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, Maryland 20852,; USA. engelse@exchange.nih.gov
- Epidemiologic studies of infection with the oncogenic human herpesvirus 8 (HHV-8) depend on serologic methods to diagnose infection. However, optimal strategies for identifying HHV-8 infection remain undefined. We therefore evaluated four enzyme-linked immunoassays (EIAs) and one immunofluorescence assay (IFA) using s
- Lipodystrophy: results of a data evaluation of patients receiving nelfinavir-containing combination therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):355-6. Unique Identifier : AIDSLINE MED/20294748
- Lewis RH; Popescu M
- Hepatitis B virus seroconversion in HIV-HBV coinfected patients treated with highly active antiretroviral therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):356-7. Unique Identifier : AIDSLINE MED/20294749
- Piroth L; Grappin M; Buisson M; Duong M; Portier H; Chavanet P
- Dietary problems in African HIV-1-infected adults, Abidjan, Cote d'Ivoire. COTRIMO-CI Study Group [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):357-8. Unique Identifier : AIDSLINE MED/20294750
- Castetbon K; Anglaret X; Attia A; Mahassadi A; Malvy D; Dabis F
- RNA viral load test for early diagnosis of vertical transmission of HIV-1 infection [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):358-60. Unique Identifier : AIDSLINE MED/20294751
- Souza IE; Azevedo ML; Succi RC; Machado DM; Diaz RS
- Adherence to triple therapy and viral load response [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):360-1. Unique Identifier : AIDSLINE MED/20294752
- Low-Beer S; Yip B; O'Shaughnessy MV; Hogg RS; Montaner JS
- Development of Kaposi sarcoma despite sustained suppression of HIV plasma viremia [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):361. Unique Identifier : AIDSLINE MED/20294753
- Khanlou H; Stein T; Farthing C
- Prevalence of drug resistance-related mutations among HIV-1s in Japan.
- Jpn J Infect Dis. 1999 Feb;52(1):21-2. Unique Identifier : AIDSLINE MED/20270630
- Sugiura W; Matsuda M; Abumi H; Yamada K; Taki M; Ishikawa M; Miura T; Fukutake K; Gouchi K; Ajisawa A; Iwamoto A; Hanabusa H; Mimaya J; Takamatsu J; Takada N; Kakishita E; Yoshioka A; Kashiwagi S; Shirahata A; Nagai Y; AIDS Research Center, National Institute of Infectious Diseases,; Tokyo 208-0011, Japan. wsugiura@nih.go.jp.
- Chemokine receptors and other surface molecules preferentially associated with human Th1 or Th2 cells.
- Microbes Infect. 1999 Jan;1(1):103-6. Unique Identifier : AIDSLINE MED/20303683
- Annunziato F; Galli G; Romagnani P; Cosmi L; Manetti R; Maggi E; Romagnani S; Institute of Internal Medicine and Immunoallergology, University; of Florence, Italy.
- Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.
- Microbes Infect. 1999 Jan;1(1):43-50. Unique Identifier : AIDSLINE MED/20303675
- Rincon M; Flavell RA; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520-8011, USA.
- New insight into the mechanisms underlying Th2 cell development and susceptibility to Leishmania major in BALB/c mice.
- Microbes Infect. 1999 Jan;1(1):59-64. Unique Identifier : AIDSLINE MED/20303677
- Launois P; Himmelrich H; Tacchini-Cottier F; Milon G; Louis JA; WHO Immunology Research and Training Center, Institute of; Biochemistry,University of Lausanne, Switzerland.
- Influence of host and parasite factors on the innate immune response and Th2 stability following infection with Leishmania major.
- Microbes Infect. 1999 Jan;1(1):65-71. Unique Identifier : AIDSLINE MED/20303678
- Hondowicz B; Scott P; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia 19104, USA.
- Non-MHC-linked genetic polymorphism controls selective development of Th2 but not inhibition of Th1 cells by soluble antigen administration.
- Microbes Infect. 1999 Jan;1(1):73-7. Unique Identifier : AIDSLINE MED/20303679
- Galbiati F; Adorini L; Roche Milano Ricerche, Milan, Italy.
- TCRgammadelta cells and viruses.
- Microbes Infect. 1999 Mar;1(3):203-12. Unique Identifier : AIDSLINE MED/20259169
- Sciammas R; Bluestone JA; Department of Microbiology and Immunology, Stanford University; School of Medicine, CA, USA.
- T-cell receptor gammadelta cells (TCRgammadelta) are often found in increased numbers during the course of several viral infections in humans. Although these findings suggest an important role for this unique subset, their precise function has not been ascertained. Recent studies in murine models of both RNA and DNA v
- NKR-mediated control of gammadelta T-cell immunity to viruses.
- Microbes Infect. 1999 Mar;1(3):219-26. Unique Identifier : AIDSLINE MED/20259171
- Gougeon ML; Boullier S; Colizzi V; Poccia F; Departement SIDA et Retrovirus, Institut Pasteur, Paris,; France.
- [Retroviruses and opportunistic infections. VII International Congress. January 30-February 2, 2000, San Francisco, USA]
- Clin Ter. 2000 Jan-Feb;151(1):7-8. Unique Identifier : AIDSLINE MED/20282282
- Navazio F; Dipartimento di Biologia Molecolare, Universita della; California, Berkeley 94720-3200, USA.
- Prospective study of IgM to Toxoplasma gondii on Beckman Coulter's Access(TM) immunoassay system and comparison with Zeus ELISA and gull IFA assays.
- Diagn Microbiol Infect Dis. 2000 Apr;36(4):237-9. Unique Identifier : AIDSLINE MED/20229601
- Liu X; Turner BP; Peyton CE; Reisner BS; Okorodudu AO; Mohammad AA; Hankins GD; Weissfeld AS; Petersen JR; Department of Pathology, University of Texas Medical Branch,; Galveston, TX 77555, USA.
- We compared a new assay for Toxoplasma IgM on the Access analyzer (Beckman Coulter, Inc., Chaska, MN, USA), a random access instrument based on the principle of paramagnetic particle enzyme immunoassay with an enzyme-linked immunosorbent assay (ELISA) (Zeus Scientific, Inc., Raritan, NJ, USA) and an immunofluorescent
- Long-term outcome after medical reversal of transtentorial herniation in patients with supratentorial mass lesions.
- Crit Care Med. 2000 May;28(5):1556-64. Unique Identifier : AIDSLINE MED/20292563
- Qureshi AI; Geocadin RG; Suarez JI; Ulatowski JA; Division of Neurosciences Critical Care, The Johns Hopkins; Medical Institutions, Baltimore, MD, USA.
- OBJECTIVE: To determine the short- and long-term outcomes after successful reversal of transtentorial herniation by medical treatment. Although it has been recognized that aggressive medical management can reverse transtentorial herniation, it is believed that overall outcome in such patients is poor. DESIGN: Prospect
- Lamivudine (3TC)-induced contact dermatitis.
- Cutis. 2000 Apr;65(4):227-9. Unique Identifier : AIDSLINE MED/20255645
- Smith KJ; Buckley R; Skelton H; Department of Dermatology, National Naval Medical Center,; Bethesda, Maryland 20889-5600, USA.
- The nucleoside analogue lamivudine ( 3TC ) is commonly used in multidrug therapy of human immunodeficiency virus-1 disease because it not only potentiates the antiviral effects of other reverse transcriptase inhibitors, but it is also relatively nontoxi
- [Legal occupational problems of hepatitis C/AIDS infection in physicians]
- Chirurg. 2000 Mar;71(3):suppl 66-9. Unique Identifier : AIDSLINE MED/20249534
- Heberer J
- 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).
- Drug Metab Dispos. 2000 May;28(5):497-502. Unique Identifier : AIDSLINE MED/20235253
- Barbier O; Turgeon D; Girard C; Green MD; Tephly TR; Hum DW; Belanger A; Laboratory of Molecular Endocrinology, CHUL Research Center,; Laval University, Quebec, Canada.
- 3 -Azido-3 -deoxythymidine ( AZT ) is frequently prescribed to patients infected with the human immunodeficiency virus. After absorption, AZT is rapidly metabolized into 3 -azido-3 -deoxy-5 -glucuronylthymidine by UDP-glucuronosyltransferase (UGT) enzym
- [Orthotopic liver transplantation in a 33-year-old patient with fulminant hepatitis B and HIV infection]
- Dtsch Med Wochenschr. 2000 Apr 28;125(17):523-6. Unique Identifier : AIDSLINE MED/20288605
- Schliefer K; Paar WD; Aydemir G; Wolff M; Rockstroh JK; Spengler U; Sauerbruch T; Medizinische Klinik und Poliklinik I, Universitat Bonn.; k.schliefer@uni-bonn.de
- HISTORY AND CLINICAL FINDINGS: A 33-year-old man with fulminant hepatitis B infection was to have an orthotopic liver transplantation (OLTX) because of the otherwise poor prognosis. During preparations for it he was found also to have an HIV-infection. INVESTIGATIONS: Preoperatively the Quick value was 9%, and he had
- Indinavir calculi: diagnosis with magnetic resonance urography.
- Eur Urol. 2000 May;37(5):634-5. Unique Identifier : AIDSLINE MED/20229685
- Hermans BP; Materne R; Marot JC; Vandercam B; Van Beers BE; Van Cangh PJ; Department of Urology, Universite Catholique de Louvain, St-Luc; University Hospital, Brussels, Belgium. benoit.hermans@skynet.be
- Apelin peptides block the entry of human immunodeficiency virus (HIV).
- FEBS Lett. 2000 May 4;473(1):15-8. Unique Identifier : AIDSLINE MED/20263719
- Zou MX; Liu HY; Haraguchi Y; Soda Y; Tatemoto K; Hoshino H; Department of Molecular Physiology, Institute for Molecular and; Cellular Regulation, Gunma University, Maebashi, Japan.
- The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the brain-derived NP-2/CD4 cells. Because apelin is an endogenous ligand for the APJ receptor
- Prevalence of HCV & HBV infection amongst HIV seropositive intravenous drug users & their non-injecting wives in Manipur, India.
- Indian J Med Res. 2000 Feb;111:37-9. Unique Identifier : AIDSLINE MED/20284478
- Saha MK; Chakrabarti S; Panda S; Naik TN; Manna B; Chatterjee A; Detels R; Bhattacharya SK; National Institute of Cholera & Enteric Diseases (ICMR),; Calcutta.
- Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections were evaluated among 77 Manipuri couples of whom all husbands were both intravenous drug users (IDUs) and human immunodeficiency virus (HIV) positive. This study showed for the first time a high prevalence of HCV (92%) and HBV (100%) infection amongst the
- Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine.
- Int J Cancer. 2000 Jun 1;86(5):725-30. Unique Identifier : AIDSLINE MED/20259436
- Chang EY; Chen CH; Ji H; Wang TL; Hung K; Lee BP; Huang AY; Kurman RJ; Pardoll DM; Wu T; Department of Pathology, School of Medicine, The Johns Hopkins; University, Baltimore, Maryland, USA.
- Granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced autologous tumor cell-based vaccines are currently one of the major forms of cancer vaccines. However, the preparation of GM-CSF-transduced autologous tumor vaccines is time-consuming and technically challenging. In addition, the host antigen present
- Toxoplasmic encephalitis in acquired immunodeficiency syndrome.
- J Assoc Physicians India. 1999 Jul;47(7):680-4. Unique Identifier : AIDSLINE MED/20241054
- Chaddha DS; Kalra SP; Singh AP; Gupta RM; Sanchetee PC
- OBJECTIVES: To study the clinical course and outcome of toxoplasmic encephalitis (TE) in patients with acquired immunodeficiency syndrome (AIDS). METHODS: Patients infected with human immunodeficiency virus (HIV) and neurological abnormality compatible with diagnosis of TE were enrolled in the study. These patients we
- Clinical profile of AIDS: a study at a referral hospital [letter]
- J Assoc Physicians India. 1999 Jul;47(7):747. Unique Identifier : AIDSLINE MED/20241076
- Srinivasan P; Narayan S
- Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.
- J Biol Chem. 2000 May 12;275(19):14316-20. Unique Identifier : AIDSLINE PDB/1EP4SF
- Ren J; Nichols C; Bird LE; Fujiwara T; Sugimoto H; Stuart DI; Stammers DK; Structural Biology Division, The Wellcome Trust Centre for Human; Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN,; United Kingdom.
- S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a complex with HIV-1
- Successive expression and activation of NFAT family members during thymocyte differentiation.
- J Biol Chem. 2000 May 12;275(19):14708-16. Unique Identifier : AIDSLINE MED/20261605
- Adachi S; Amasaki Y; Miyatake S; Arai N; Iwata M; Integrative Projects, Mitsubishi Kasei Institute of Life; Sciences, Machida-shi, Tokyo 194-8511, Japan.
- Differentiation of immature CD4(+)CD8(+) thymocytes to mature CD4(+) or CD8(+) T cells is induced by positive selection and appears to involve calcineurin-dependent activation of NFAT, a family of transcription factors. NFATx is predominantly expressed in CD4(+)CD8(+) thymocytes, whereas NFATp and NFATc are expressed
- Benign monoclonal expansion of CD8+ lymphocytes in HIV infection.
- Unique Identifier : AIDSLINE MED/20282542
- Smith PR; Cavenagh JD; Milne T; Howe D; Wilkes SJ; Sinnott P; Forster GE; Helbert M; Department of Genitourinary Medicine, Royal Hospitals NHS Trust,; Whitechapel, London, UK.
- BACKGROUND: A transient expansion of the CD8+ T cell pool normally occurs in the early phase of HIV infection. Persistent expansion of this pool is observed in two related settings: diffuse infiltrative lymphocytosis syndrome (DILS) and HIV associated CD8+ lymphocytosis syndrome. AIM: To investigate a group of HIV inf
- Monitoring patients with HIV disease.
- J Clin Pathol. 2000 Apr;53(4):266-72. Unique Identifier : AIDSLINE MED/20282529
- Helbert M; Breuer J; London NHS Trust, UK. mrhelbert@mds.qmw.ac.uk
- Cytokine receptor signaling pathways.
- J Allergy Clin Immunol. 2000 May;105(5):877-88. Unique Identifier : AIDSLINE MED/20270099
- Leonard WJ; Lin JX; Laboratory of Molecular Immunology, National Heart, Lung, and; Blood Institute, National Institutes of Health, Bethesda, MD; 20892-1674, USA.
- Cytokines represent a diverse group of molecules that transmit intercellular signals. These signals may either be autocrine (where the same cell both produces the cytokine and responds to it) or paracrine (where the cytokine is made by one cell and acts on another). Both these situations can occur simultaneously. Cyto
- Deficient cytokine response of human allergen-specific T lymphocytes from humanized SCID mice and reconstitution by professional antigen-presenting cells.
- J Allergy Clin Immunol. 2000 May;105(5):967-74. Unique Identifier : AIDSLINE MED/20270112
- Jarman ER; Perschke K; Montermann E; Herz U; Renz H; Knop J; Reske-Kunz AB; Clinical Research Unit, Department of Dermatology, Johannes; Gutenberg-University, Mainz, Germany.
- BACKGROUND: Hu-PBL-SCID mice generated by the transfer of PBMCs from atopic individuals may provide a physiologic in vivo model for investigating human responses to allergens and potential approaches toward immunotherapy. OBJECTIVE: This study was undertaken to investigate the functional activity and cytokine profile
- gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.
- J Allergy Clin Immunol. 2000 May;105(5):975-82. Unique Identifier : AIDSLINE MED/20270113
- Patke CL; Shearer WT; Departments of Pediatrics and Microbiology and Immunology, Baylor; College of Medicine, and the Department of Allergy and; Immunology, Texas Children's Hospital, Houston, TX 77030, USA.
- BACKGROUND: It is well known that HIV-1 infection induces profound alterations in the immune system, including hyperactivation of B cells. TNF-alpha induces HIV-1 replication and immunodysregulation, including polyclonal B-cell activation. OBJECTIVE: We sought to determine the effects of surface-binding HIV-1 envelope
- Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors.
- J Allergy Clin Immunol. 2000 May;105(5):988-96. Unique Identifier : AIDSLINE MED/20270115
- Bellinghausen I; Brand U; Knop J; Saloga J; Department of Dermatology, University of Mainz, Germany.
- BACKGROUND: Because of their production of IL-12, mature dendritic cells (DC) are potent inducers of T(H)1 responses. However, recent reports have demonstrated that DCs can also induce T(H)2 differentiation. OBJECTIVE: In the current study we investigated which immune response is induced by DCs in naive CD45RA(+) or m
- Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes.
- J Immunol. 2000 May 15;164(10):4996-9. Unique Identifier : AIDSLINE MED/20261627
- Goetzl EJ; Kong Y; Voice JK; Department of Medicine, University of California, San Francisco,; CA 94143, USA. egoetzel@itsa.ucsf.edu
- Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) from platelets and macrophages mediate T cell functions. Endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) are specific for S1P (Edg-1, -3, -5, and -8 Rs) and LPA (Edg-2, -4, and -7 Rs). Human T cell tumors express many Edg Rs fo
- Quantification of cell turnover kinetics using 5-bromo-2'-deoxyuridine.
- J Immunol. 2000 May 15;164(10):5049-54. Unique Identifier : AIDSLINE MED/20261637
- Bonhoeffer S; Mohri H; Ho D; Perelson AS; Friedrich Miescher Institute, Basel, Switzerland.
- 5-Bromo-2 -deoxyuridine (BrdU) is frequently used to measure the turnover of cell populations in vivo. However, due to a lack of detailed mathematical models that describe the uptake and loss of BrdU in dividing cell populations, assessments of cell turnover kinetics have been largely qualitative rather than quantitat
- Sequential cleavage by metallopeptidases and proteasomes is
- Unique Identifier : AIDSLINE MED/20261640 P
- Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis.
- J Immunol. 2000 May 15;164(10):5078-87. Unique Identifier : AIDSLINE MED/20261641
- Somma F; Tuosto L; Montani MS; Di Somma MM; Cundari E; Piccolella E; Department of Cellular and Developmental Biology, "La Sapienza"; University, Rome, Italy.
- In the present study, we have aimed at clarifying the CD4-dependent molecular mechanisms that regulate human memory T cell susceptibility to both Fas (CD95)-dependent and Bcl-2-dependent apoptotic pathways following antigenic challenge. To address this issue, we used an experimental system of viral and alloantigen-spe
- Human vascular endothelial cells stimulate memory but not naive CD8+ T cells to differentiate into CTL retaining an early activation phenotype.
- J Immunol. 2000 May 15;164(10):5146-55. Unique Identifier : AIDSLINE MED/20261650
- Dengler TJ; Pober JS; Interdepartmental Program in Vascular Biology and; Transplantation, Boyer Center for Molecular Medicine, Yale; University School of Medicine, New Haven, CT 06510, USA.
- Endothelial cell (EC)-selective alloreactive CTL may mediate alloimmune vascular injury. In the present study, EC-selective CTL were generated in cocultures of purified human CD8+ T cells with allogeneic EC and were compared with conventional CTL against corresponding B lymphoblastoid cells (BLC). EC caused activation
- Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis.
- J Immunol. 2000 May 15;164(10):5156-66. Unique Identifier : AIDSLINE MED/20261651
- Manna SK; Aggarwal BB; Cytokine Research Section, Department of Bioimmunotherapy,; University of Texas M. D. Anderson Cancer Center, Houston, TX; 77030, USA.
- HIV-tat protein, like TNF, activates a wide variety of cellular responses, including NF-kappa B, AP-1, c-Jun N-terminal kinase (JNK), and apoptosis. Whether HIV-tat transduces these signals through the same mechanism as TNF is not known. In the present study we investigated the role of the T cell-specific tyrosine kin
- An altered peptide ligand antagonizes antigen-specific T cells of patients with human T lymphotropic virus type I-associated neurological disease.
- J Immunol. 2000 May 15;164(10):5192-8. Unique Identifier : AIDSLINE MED/20261655
- Kubota R; Soldan SS; Martin R; Jacobson S; Neuroimmunology Branch, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda, MD; 20892, USA.
- Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory neurologic disease associated with HTLV-I infection, in which chronically activated, HTLV-I-specific CD8+ CTL have been suggested to be immunopathogenic. In HLA-A2 HAM/TSP patients, CD8+ HTLV-I-sp
- Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL/6 mice.
- J Immunol. 2000 May 15;164(10):5236-44. Unique Identifier : AIDSLINE MED/20261661
- Karachunski PI; Ostlie NS; Monfardini C; Conti-Fine BM; Department of Biochemistry, Molecular Biology and Biophysics,; University of Minnesota, St. Paul, MN 55108, USA.
- Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis (EMG). Th1 cells facilitate EMG development. IFN-gamma and IL-12 induce Th1 responses: we investigated whether these cytokines are necessary for EMG development. We immunized wild-type (WT) C57BL/6 mice and IFN-gamma and IL-12 knocko
- Structural analysis of CTLA-4 function in vivo.
- J Immunol. 2000 May 15;164(10):5319-27. Unique Identifier : AIDSLINE MED/20261671
- Masteller EL; Chuang E; Mullen AC; Reiner SL; Thompson CB; Gwen Knapp Center for Lupus and Immunology, University of; Chicago, Chicago, IL 60637, USA. emastell@delphi.bsd.uchicago.edu
- CTLA-4-mediated inhibition of T cell activation may be accomplished by competition for ligands and/or by signals mediated through the intracellular domain. Studies have implicated Tyr201 in the cytoplasmic domain of CTLA-4 in regulating CTLA-4 signal transduction and intracellular trafficking. To investigate the mecha
- Modulation of HIV-1 replication by a novel RhoA effector activity.
- J Immunol. 2000 May 15;164(10):5369-74. Unique Identifier : AIDSLINE MED/20261677
- Wang L; Zhang H; Solski PA; Hart MJ; Der CJ; Su L; Department of Microbiology, Lineberger Comprehensive Cancer; Center, School of Medicine, School of Public Health, University; of North Carolina, Chapel Hill, NC 27599, USA.
- The RhoA GTPase is involved in regulating actin cytoskeletal organization, gene expression, cell proliferation, and survival. We report here that p115-RhoGEF, a specific guanine nucleotide exchange factor (GEF) and activator of RhoA, modulates HIV-1 replication. Ectopic expression of p115-RhoGEF or Galpha13, which act
- Thymic and postthymic regulation of diabetogenic CD8 T cell development in TCR transgenic nonobese diabetic (NOD) mice.
- J Immunol. 2000 May 15;164(10):5466-73. Unique Identifier : AIDSLINE MED/20261691
- Kanagawa O; Shimizu J; Vaupel BA; Center for Immunology and Department of Pathology, Washington; University School of Medicine, St. Louis, MO 63110, USA.; kanagawa@pathbox.wustl.edu
- Natural development of diabetes in nonobese diabetic (NOD) mice requires both CD4 and CD8 T cells. Transgenic NOD mice carrying alphabeta TCR genes from a class I MHC (Kd)-restricted, pancreatic beta cell Ag-specific T cell clone develop diabetes significantly faster than nontransgenic NOD mice. In these TCR transgeni
- Impact of HIV-1 infection on VH3 gene repertoire of naive human B cells.
- J Immunol. 2000 May 15;164(10):5482-91. Unique Identifier : AIDSLINE MED/20261693
- Scamurra RW; Miller DJ; Dahl L; Abrahamsen M; Kapur V; Wahl SM; Milner EC; Janoff EN; Center for Mucosal and Vaccine Biology, Infectious Disease; Section, Veteran Affairs Medical Center, University of Minnesota; School of Medicine, Minneapolis, MN 55417, USA.
- B cells of the largest Ig variable heavy chain gene (VH) family, VH3, are reportedly decreased in patients with late stage HIV-1 disease. This deficit may contribute to their impaired responses to infections and vaccines. We confirmed that the VH3 family was underrepresented in serum IgM proteins, with a 45% decrease
- Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis.
- J Immunol. 2000 May 15;164(10):5499-507. Unique Identifier : AIDSLINE MED/20261695
- Olivares-Villagomez D; Wensky AK; Wang Y; Lafaille JJ; Division of Molecular Pathogenesis, Skirball Institute of; Biomolecular Medicine, Sackler Institute of Graduate Biomedical; Sciences, New York University Medical Center, New York, NY 10016,; USA.
- Spontaneous experimental autoimmune encephalomyelitis arises in 100% of mice exclusively harboring myelin basic protein-specific T cells, and can be prevented by a single injection of CD4+ T cells obtained from normal donors. Given the powerful regulatory effect of the transferred T cells, we further investigated thei
- Intracellular staining for TNF and IFN-gamma detects different frequencies of antigen-specific CD8(+) T cells.
- J Immunol Methods. 2000 Apr 21;238(1-2):107-17. Unique Identifier : AIDSLINE MED/20223493
- Badovinac VP; Harty JT; Department of Microbiology and Interdisciplinary Graduate Program; in Immunology, University of Iowa, Iowa City, IA 52242, USA.
- CD8(+) T lymphocytes are important mediators of adaptive immunity against certain viral, protozoan and bacterial pathogens. Activated CD8(+) T cells are able to induce cytolysis of infected cells (perforin and CD95-CD95L mediated pathways) and also elaborate cytokines, including IFN-gamma and TNF after appropriate MHC
- A rapid method for estimating the binding of ligands to ELISA microwells.
- J Immunol Methods. 2000 Apr 21;238(1-2):143-50. Unique Identifier : AIDSLINE MED/20223496
- Steinitz M; Baraz L; The Department of Pathology, The Hebrew University - Hadassah; Medical School, POB 12272, Jerusalem, Israel.; michaels@md2.huji.ac.il
- This report presents a rapid and simple assay for estimating to what extent the surface of ELISA microwells is coated by a ligand of choice such as, for example, proteins, peptides, hormones, polysaccharides and nucleic acids. The method also provides a practical approach for defining the conditions required for optim
- Mapping of B-cell epitopes in rabbits immunised with various gag antigens for the production of HIV-1 gag capture ELISA reagents.
- J Immunol Methods. 2000 Apr 21;238(1-2):69-80. Unique Identifier : AIDSLINE MED/20223489
- Devito C; Levi M; Broliden K; Hinkula J; Microbiology and Tumorbiology Center, Karolinska Institute, 171; 77, Stockholm, Sweden.
- An HIV-1 p24 capture enzyme linked immunosorbent assay (ELISA) was developed and used in a study of B-cell epitopes in rabbits immunised with different gag p24 antigens. Rabbits were immunised with virion HIV-1/Lai, baculovirus recombinant p24, Escherichia coli recombinant p24-15 and a mixture of synthetic peptides re
- Heat-inducible vectors for use in gene therapy.
- Int J Hyperthermia. 2000 Mar-Apr;16(2):171-81. Unique Identifier : AIDSLINE MED/20224815
- Gerner EW; Hersh EM; Pennington M; Tsang TC; Harris D; Vasanwala F; Brailey J; Department of Radiation Oncology, Cancer Biology Section, Arizona; Cancer Center, The University of Arizona, Tucson 85724, USA.; egerner@azcc.arizona.edu
- The objectives of this study were to quantity and compare the activities of a minimal heat shock (HS) promoter and other promoters used in gene therapy applications, and to identify strategies to amplify the heat inducibility of therapeutic genes. Human tumour cells were transiently or stably transfected with the HS p
- Characteristics of persons with AIDS in rural and urban Georgia: use of alcohol and other drugs, history of sexually transmitted diseases and tuberculosis, high-risk sexual behaviors, and problems obtaining social services.
- J Med Assoc Ga. 2000 Spring;89(1):10-4. Unique Identifier : AIDSLINE MED/20280605
- Beltrami JF; Fann SA; Toomey KE; Emory University School of Medicine, USA.
- The Helsinki Declaration regarding ethics in clinical research.
- J Med Assoc Thai. 2000 Mar;83(3):330-2. Unique Identifier : AIDSLINE MED/20268734
- Wilde H; Phaosavasdi S; Tannirandorn Y; Taneepanichskul S; Pruksapong C; Queen Saovabha Memorial Institute, Thai Red Cross Society,; Bangkok, Thailand.
- Primary prophylaxis for individuals with severe haemophilia: how many hospital visits could treatment prevent?
- J Intern Med. 2000 Apr;247(4):493-9. Unique Identifier : AIDSLINE MED/20253226
- Miners AH; Sabin CA; Tolley KH; Lee CA; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK. alec@rfhsm.ac.uk
- OBJECTIVES: To assess how many hospital visits primary prophylaxis with clotting factor could prevent. DESIGN: The potential for reducing hospital visits was assessed by comparing rates of in-patient, Out-patient and day-case visits per patient-year for individuals with severe (
- Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor.
- J Exp Med. 2000 Apr 3;191(7):1187-96. Unique Identifier : AIDSLINE MED/20213460
- Lucas PJ; Kim SJ; Melby SJ; Gress RE; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
- The immune system, despite its complexity, is maintained at a relative steady state. Mechanisms involved in maintaining lymphocyte homeostasis are poorly understood; however, recent availability of transgenic (Tg) and knockout mouse models with altered balance of lymphocyte cell populations suggest that cytokines play
- gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors.
- J Neurochem. 2000 Jun;74(6):2373-9. Unique Identifier : AIDSLINE MED/20281841
- Catani MV; Corasaniti MT; Navarra M; Nistico G; Finazzi-Agro A; Melino G; Biochemistry Laboratory, IDI-IRCCS, c/o Department of; Experimental Medicine, University of Rome Tor Vergata, Rome,; Italy.
- To infect target cells, the human immunodeficiency virus (HIV) type I (HIV-1) must engage not only the well-known CD4 molecule, but it also requires one of several recently described coreceptors. In particular, the CXCR4 (LESTR/fusin) receptor allows fusion and entry of T-tropic strains of HIV, whereas CCR5 is the maj
- Ethambutol related headache in HIV infection: sensitisation to normal CSF pressure? A case report [letter]
- J Neurol Neurosurg Psychiatry. 2000 Apr;68(4):535-6. Unique Identifier : AIDSLINE MED/20297615
- Kaube H; Mummel P; Koeppen S
- A role for complement in the rejection of porcine ventral mesencephalic xenografts in a rat model of Parkinson's disease.
- J Neurosci. 2000 May 1;20(9):3415-24. Unique Identifier : AIDSLINE MED/20241984
- Barker RA; Ratcliffe E; McLaughlin M; Richards A; Dunnett SB; Cambridge Centre for Brain Repair, Forvie Site, Cambridge CB2; 2PY, United Kingdom. rab46@cus.cam.ac.uk
- Vascularized whole organ discordant xenografts placed in the periphery are rejected by a rapid hyperacute process that involves preformed antibody binding to the xeno-antigens on the donor endothelial cells with complement activation. In the CNS, xenografts are classically thought to be rejected more slowly by a T-c
- High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice.
- J Nutr. 2000 May;130(5):1132-9. Unique Identifier : AIDSLINE MED/20263906
- Cui D; Moldoveanu Z; Stephensen CB; Department of International Health, School of Public Health,; University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Vitamin A supplementation during acute pneumonia has not improved recovery in most human clinical trials. We hypothesize that high vitamin A intake may decrease the production of T-helper type-1 (Th1) cytokines and thereby inhibit antiviral responses. Such decreases might impair recovery from viral respiratory infecti
- The dynamic link between the integrity of the immune system and zinc status.
- J Nutr. 2000 May;130(5S Suppl):1399S-406S. Unique Identifier : AIDSLINE MED/20272023
- Fraker PJ; King LE; Laakko T; Vollmer TL; Department of Biochemistry, Michigan State University, East; Lansing, MI 48824, USA.
- The results of more than three decades of work indicate that zinc deficiency rapidly diminishes antibody- and cell-mediated responses in both humans and animals. The moderate deficiencies in zinc noted in sickle cell anemia, renal disease, chronic gastrointestinal disorders and acrodermatitis enteropathica; subjects w
- Zinc status in human immunodeficiency virus infection.
- J Nutr. 2000 May;130(5S Suppl):1421S-3S. Unique Identifier : AIDSLINE MED/20272026
- Baum MK; Shor-Posner G; Campa A; Center for Disease Prevention, Department of Psychiatry and; Behavioral Medicine, University of Miami School of Medicine,; Miami, FL 33136, USA.
- There is substantial evidence to support an important role for zinc in immune processes. Adequate zinc status is essential for T-cell division, maturation and differentiation; lymphocyte response to mitogens; programmed cell death of lymphoid and myeloid origins; gene transcription; and biomembrane function. Lymphocyt
- Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections.
- J Nutr. 2000 May;130(5S Suppl):1424S-31S. Unique Identifier : AIDSLINE MED/20272027
- Mocchegiani E; Muzzioli M; Immunology Centre, Research Department, Italian National Research; Centres on Aging, 60121 Ancona, Italy.
- The relevance of zinc in resistance to infections by virus, fungi and bacteria is recognized because of its pivotal role in the efficiency of the entire immune system, in particular in conferring biological activity to a thymic hormone called thymulin, which has differentiation properties on T-cell lines. In infection
- Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD.
- J Pathol. 2000 Apr;190(5):619-26. Unique Identifier : AIDSLINE MED/20193768
- de Boer WI; Sont JK; van Schadewijk A; Stolk J; van Krieken JH; Hiemstra PS; Department of Pulmonology, Leiden University Medical Center,; Leiden, The Netherlands. pdeboer@pulmonology.azl.nl
- Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death, with cigarette smoking among the main risk factors. Hallmarks of COPD include chronic airflow obstruction and chronic inflammation in the airway walls or alveolar septa. An earlier study reported elevated numbers of macrophages and
- Effect of trimethoprim on the renal clearance of lamivudine in rats.
- J Pharm Pharmacol. 2000 Mar;52(3):315-20. Unique Identifier : AIDSLINE MED/20218346
- Takubo T; Kato T; Kinami J; Hanada K; Ogata H; Safety Evaluation Department, Glaxo Wellcome K.K., Tsukuba; Research Laboratories, Ibaraki, Japan.
- Lamivudine undergoes minimal metabolism and renal clearance of the unchanged drug is the predominant mechanism of clearance. The effect of trimethoprim on the renal clearance of lamivudine was investigated in rats in-vivo. Total renal clearance of lam
- AIDS-Related opportunistic illness and potent antiretroviral therapy [letter]
- JAMA. 2000 May 24-31;283(20):2653-4. Unique Identifier : AIDSLINE MED/20280033
- Engels EA; Frisch M; Biggar RJ; Goedert JJ
- I wish I was a chimpanzee [letter]
- Lancet. 2000 May 6;355(9215):1649-50. Unique Identifier : AIDSLINE MED/20279416
- Van de Perre P
- Lipids and retroviruses.
- Lipids. 2000 Feb;35(2):123-30. Unique Identifier : AIDSLINE MED/20218467
- Raulin J; Universite Denis Diderot (Paris 7), France. craulin@aol.com
- The role that lipids may play in enveloped viruses is reviewed. Small lipid molecules can influence retrovirus binding to cell receptors, plasma membrane fusion, and transcription. Palmitoylation following myristoylation of viral glycoproteins is required at the transmembrane level for signal transduction as well as f
- [Prevalence of HIV infection in patients with pellagra and pellagra-like erythemas]
- Med Trop (Mars). 1999;59(4):365-7. Unique Identifier : AIDSLINE MED/20276724
- Pitche P; Kombate K; Tchangai-Walla K; Service de Dermato-Venereologie, Centre Hospitalier; Universitaire Tokoin, Lome, Togo.; palokinam.pitche@syfed.tg.refer.org
- Pellagra is a systemic disorder caused by severe niacin deficiency. While uncommon in Europe and North America, pellagra and pellagra-like erythema are frequently encountered in undernourished adults in poor African countries. The purpose of this three-year prospective study was to determine the prevalence of HIV infe
- [Coexistence of mass hysteria, konzo and HTLV-1 virus in the Democratic Republic of the Congo]
- Med Trop (Mars). 1999;59(4):378-82. Unique Identifier : AIDSLINE MED/20276728
- Tshala K; Nunga M; Pukuta S; Mutombo L; Beya E; Tshoko K; Mampunza M; Centre Neuropsychopathologique du Mont-Amba, Universite de; Kinshasa, Republique Democratique du Congo.; desire_tshala@yahoo.com
- A cross-sectional study was carried out in Pindi located 115 kilometers from Kikwit, Democratic Republic of the Congo to characterize a local school epidemic involving paralysis of the lower extremities, identify risk factors, and establish differential diagnosis with konzo and sp
- Field recognition of pathogen and HIV self.
- Med Hypotheses. 2000 Mar;54(3):381-4. Unique Identifier : AIDSLINE MED/20247387
- Kerven R; University Station, Syracuse, NY, USA.
- There is evidence to suggest that the HIV virus is never presented clearly and completely to the immune system. It is possible there is an additional recognition system in skin it misses. By bypassing the skin in inoculation or neutralizing skin presentation in semen, an envelope that may modify immune response, patho
- Serum S100B levels in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.
- Neurology. 2000 May 23;54(10):2021-2. Unique Identifier : AIDSLINE MED/20284150
- Walz R; Portela LV; Tort AB; Neto EC; Fernandes LN; Goncalves CA; Souza DO; Servico de Neurologia do Hospital Regional de Sao Jose, Sao; Jose, SC, Brazil. rogerwalz@hotmail.com
- HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300.
- Oncogene. 2000 Apr 20;19(17):2155-64. Unique Identifier : AIDSLINE MED/20273229
- Nicot C; Mahieux R; Opavsky R; Cereseto A; Wolff L; Brady JN; Franchini G; Basic Research Laboratory, National Cancer Institute, Bethesda,; Maryland 20814, USA.
- The c-Myb proto-oncogene is preferentially expressed in hematopoietic lineages, and highly expressed in several leukemia types. The Human T-cell Leukemia Virus Type I (HTLV-I) is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL). A previous report suggested that Tax, the viral transactivator, is able to s
- HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents.
- Oncogene. 2000 Apr 27;19(18):2240-8. Unique Identifier : AIDSLINE MED/20282797
- Kao SY; Lemoine FJ; Mariott SJ; Department of Molecular Virology and Microbiology, Baylor College; of Medicine, Houston, Texas 77030, USA.
- Transient HTLV-1 Tax expression suppresses cellular nucleotide excision repair, and this effect correlates with Tax transactivation of the proliferating cell nuclear antigen promoter. The inability to repair DNA damage typically induces apoptotic cell death. Therefore, we investigated the effect of Tax-mediated suppre
- The effect of mutations in the HIV-1 nucleocapsid protein on strand transfer in cell-free reverse transcription reactions.
- Nucleic Acids Res. 2000 Apr 15;28(8):1724-9. Unique Identifier : AIDSLINE MED/20200604
- Hsu M; Rong L; de Rocquigny H; Roques BP; Wainberg MA; McGill University AIDS Centre, Jewish General Hospital,; Montreal, Canada.
- Interactions between the nucleocapsid protein (NC) and reverse transcriptase of HIV-1 have been shown to promote the initiation of reverse transcription. We assayed the effect of NC on later events, using a strand transfer system with donor and acceptor HIV RNA templates and found that the presence of NC resulted in i
- [Acinetobacter baumannii community-acquired pneumonia in a patient with HIV infection]
- Presse Med. 2000 Apr 15;29(14):788-9. Unique Identifier : AIDSLINE MED/20276694
- Megarbane B; Bruneel F; Bedos JP; Wolff M; Regnier B
- Role of the p38 and MEK-1/2/p42/44 MAP kinase pathways in the differential activation of human immunodeficiency virus gene expression by ultraviolet and ionizing radiation.
- Photochem Photobiol. 2000 Apr;71(4):455-9. Unique Identifier : AIDSLINE MED/20284611
- Taher MM; Hershey CM; Oakley JD; Valerie K; Department of Radiation Oncology, Massey Cancer Center, Medical; College of Virginia, Virginia Commonwealth University, Richmond; 23298-0058, USA.
- Ultraviolet (UV) radiation is a potent activator of human immunodeficiency virus (HIV) gene expression in a HeLa cell clone having stably integrated copies of an HIV cat (cat gene under control of the HIV promoter) reporter construct, whereas ionizing radiation is ineffective. UV-activated HIV gene expression is compl
- Reversibility of HIV drug resistance [comment]
- Science. 2000 May 26;288(5470):1299. Unique Identifier : AIDSLINE MED/20303729
- Davenport MP; School of Pathology, University of New South Wale,s Kensington,; NSW 2052, Australia. m.davenport@unsw.edu.au
- The risk of occupational HIV exposure among Thai healthcare workers.
- Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):496-503. Unique Identifier : AIDSLINE MED/20234691
- Pungpapong S; Phanuphak P; Pungpapong K; Ruxrungtham K; Department of Medicine, Faculty of Medicine, Chulalongkorn; University, Bangkok, Thailand.
- To analyze the incidence of occupational exposure to HIV in a large group of healthcare workers at the 2 Thai Red Cross hospitals, prospectively collected during a seven-year period in order to find out the causes and circumstances that prone to exposure, the interventions that may minimize the exposure and the conseq
- The serological status of Solomon Island blood donors.
- Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):542-5. Unique Identifier : AIDSLINE MED/20234699
- Lucas RE; Faoagali JL; Medical Unit, Honiara Central Hospital, Solomon Islands.; Rick.Lucas@nt.gov.au
- The serological status of Solomon Island blood donors in 1995 and in particular the seroprevalence of antibodies to Hepatitis B and C and prevalence of risk factors for these chronic infections was studied. A questionnaire of risk factors for Hepatitis B and C was undertaken. All blood donors had been previously scree
- Immunoblotting and enzyme linked-immunosorbent assay for diagnosis of toxoplasma infection in HIV Thai patients.
- Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):580-2. Unique Identifier : AIDSLINE MED/20234707
- Wongkamchai S; Mahakittikun V; Dekumyoy P; Onrotchanakun J; Department of Parasitology, Faculty of Medicine, Siriraj; Hospital, Bangkok, Thailand.
- Toxoplasma gondii has been recognized as an important cause of morbidity and mortality among immunocompromised persons. The diagnosis of T. gondii infection is most often based on serological tests results. Serological diagnosis can be limited in AIDS patients because of depressed antibody responses. Fifty serum sampl
- Amebic liver abscess in an elderly AIDS patient.
- Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):594-5. Unique Identifier : AIDSLINE MED/20234711
- Ohnishi K; Kimura K; Department of Infectious Diseases, Tokyo Metropolitan Bokutoh; General Hospital, Sumida City, Japan.
- An elderly bisexual male AIDS patient, whose CD4 cell count was 128/mm3 and HIV-RNA was 3.0x10(5) copies/ml, was admitted because of amebic liver abscess and poor nutritional condition. He was treated with daily doses of 1,500 mg of metronidazole for 14 days for amebic liver abscess and with anti-HIV drugs; good thera
- Alterations of thymocyte development, thymic emigrants and peripheral T cell population in rats exposed to 2,3,7, 8-tetrachlorodibenzo-p-dioxin.
- Unique Identifier : AIDSLINE MED/20235631 P
- Nohara K; Ushio H
- HHV-8: a newly recognized pathogen in transplantation [comment]
- Transplantation. 2000 May 15;69(9):1768-9. Unique Identifier : AIDSLINE MED/20289017
- Regamey N; Cathomas G; Basel University Hospital, University Children's Hospital, Base,; Switzerland.
- Outcome of kidney transplant recipients with previous human herpesvirus-8 infection [see comments]
- Transplantation. 2000 May 15;69(9):1776-9. Unique Identifier : AIDSLINE MED/20289022
- Frances C; Mouquet C; Marcelin AG; Barete S; Agher R; Charron D; Benalia H; Dupin N; Piette JC; Bitker MO; Calvez V; Department of Internal Medicine, Hopital Pitie-Salpetriere,; Paris, France. camille.frances@psl.ap-hop-paris.fr
- BACKGROUND: The consequences of a prior human herpesvirus-8 (HHV-8) infection in kidney-transplant recipients are still partially unknown. The aim of this monocentric study was to determine the prevalence of HHV-8-seropositive patients at the time of transplantation and to identify the main clinical events of these HH
- Retroviruses in plants?
- Trends Genet. 2000 Apr;16(4):151-2. Unique Identifier : AIDSLINE GENBANK/AB026651
- Peterson-Burch BD; Wright DA; Laten HM; Voytas DF; Department of Zoology and Genetics, Iowa State University, Ames,; IA 50011, USA. brookepb@iastate.edu
- Pretransplantation human herpes virus 8 seropositivity as a risk factor for Kaposi's sarcoma in kidney transplant recipients.
- Transplant Proc. 2000 May;32(3):526-7. Unique Identifier : AIDSLINE MED/20274134
- Cattani P; Nanni G; Graffeo R; Capuano M; Cerimele F; La Parola IL; Diociaiuti A; Pozzetto U; Cerimele D; Fadda G; Castagneto M; Institute of Microbiology, Transplant Unit, Institute of; Dermatology, Universita Cattolica del Sacro Cuore, Rome, Italy.
- [The improvement in the infectious safety of blood component therapy]
- Unique Identifier : AIDSLINE MED/20274687
- Zhiburt EB; Kas'ianov AD
- Neuronal damage of the substantia nigra in HIV-1 infected brains.
- Acta Neuropathol (Berl). 2000 Apr;99(4):376-84. Unique Identifier : AIDSLINE MED/20246717
- Itoh K; Mehraein P; Weis S; Institute of Neuropathology, Ludwig-Maximilians-University,; Munich, Germany.
- Extrapyramidal motor disorders are frequently noted in HIV-1-infected patients. In the present study, the substantia nigra was analyzed morphometrically to detect neuronal changes which might contribute to the pathogenetic mechanisms causing extrapyramidal motor dysfunction in HIV-1-infected patients. The numerical de
- Significant reduction in HIV-1 plasma viral load but not in proviral infected cells during sub-optimal antiretroviral therapy.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):1-3. Unique Identifier : AIDSLINE MED/20224952
- Riva E; Antonelli G; Solmone MC; Turriziani O; Narciso P; Tozzi V; Dianzani F; Institute of Virology, University La Sapienza, Roma, Italy.
- Attempts to eradicate HIV infection through highly active antiretroviral therapy (HAART) in the very early stages of the infection have failed due to the resumption of viral replication from unknown reservoirs. It has been postulated that antiretroviral therapy capable of suppressing viral replication, as shown by red
- Genotype and phenotype resistance: an overview.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):11-4. Unique Identifier : AIDSLINE MED/20224955
- Angarano G; Monno L; Clinic of Infectious Diseases, University of Bari, Italy.; g.angarano@clininf.uniba.it
- Drug resistance is a major factor contributing to the failure of antiretroviral therapy. The rapid turnover of the human immunodeficiency virus type 1 (HIV-1) and the error-prone reverse transcriptase both contribute to the extensive emergence of resistant variants. The understanding of resistance and cross-resistance
- HIV neutralizing IgA in exposed seronegative subjects recognise an epitope within the gp41 coiled-coil pocket.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):15-21. Unique Identifier : AIDSLINE MED/20224956
- Pastori C; Barassi C; Piconi S; Longhi R; Villa ML; Siccardi AG; Clerici M; Lopalco L; DIBIT and Infectious Disease Clinic, San Raffaele Scientific; Institute, Milano, Italy.
- Human immunodeficiency virus (HIV)-specific IgA can be detected in cervical secretions, saliva, and sera of HIV-infected and HIV-uninfected individuals with a known exposure to the virus. IgA from HIV-uninfected exposed seronegative individuals (ESN) neutralize in vitro primary strains of HIV-1. We analyzed the epitop
- Control of viral replication and disease onset in cynomolgus monkeys by HIV-1 TAT vaccine.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):22-6. Unique Identifier : AIDSLINE MED/20224957
- Ensoli B; Cafaro A; Laboratory of Virology, Istituto Superiore di Sanita, Roma,; Italy. ensoli@virus1.net.iss.it
- The Tat protein of HIV is produced early after infection and it is essential for viral replication and transmission. Tat is released by infected lymphocytes and is detected in the serum of HIV-infected patients. Extracellular Tat enters cells, where promotes HIV replication. Several studies suggest that humoral and ce
- Ex-vivo purging of circulating monocytes results in immunovirologic improvement in partially HAART responder HIV-infected patients.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):27-31. Unique Identifier : AIDSLINE MED/20224958
- Beretta A; Clerici M; Hasson H; Fumagalli L; Trabattoni D; Lillo F; Ferrante P; Saniabadi AR; Adachi M; Lazzarin A; CIRBS, Hospital St. Joseph, Paris, France.; giuliana.fusetti@hsr.it
- AIDS pathogenesis results from a complex array of immune alterations which include, among others, changes in the pattern of cytokine production. Some monocyte-derived cytokines, like TNFalpha play a major role in HIV pathogenesis. TNFalpha transactivates HIV NF-kB thereby inducing viral replication, potentiates HIV re
- HIV treatment: an overview.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):32-3. Unique Identifier : AIDSLINE MED/20224959
- Moroni M; Infectious Tropical Diseases Institute, University of Milano,; Italy.
- HIV therapy in the post-eradication era.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):34-7. Unique Identifier : AIDSLINE MED/20224960
- Vella S; Palmisano L; Laboratory of Virology, Istituto Superiore di Sanita, Roma,; Italy.
- Over the past three years, most efforts of virologists and immunologists involved in the field of Human Immunodeficiency Virus (HIV) have been focussed on strategies aimed at eradicating the infection. So far, however, all the approaches have been unsuccessful. Indeed, even if the currently available potent antiretrov
- Evaluation of T-cell response to CD3 plus CD28 monoclonal antibodies in HIV-1 infected subjects treated with highly active antiretroviral therapy.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):38-40. Unique Identifier : AIDSLINE MED/20224961
- Carlesimo M; Bernardi ML; Mattiacci G; Pierdominici M; Ferrara R; Donnanno S; Alario C; Aiuti F; Department of Clinical Medicine, University of Roma La Sapienza,; Italy.
- To investigate whether highly active antiretroviral therapy (HAART) could improve CD28 molecule expression and CD28-costimulation pathway function we tested the effect of CD28-costimulation on T cell receptor/CD3 induced proliferative responses in a group of HIV-1-infected subjects with CD4+ cells>200/mmc before and a
- Complexity and dynamics of HIV-1 quasispecies.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):4-6. Unique Identifier : AIDSLINE MED/20224953
- Menzo S; Bagnarelli P; Monachetti A; Fiorelli L; Clementi M; Institute of Microbiology, University of Ancona, Italy.
- The human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins mediate virus entry into target cells by binding receptors of the cell membrane and fusing viral and cellular structures. In particular, recent crystallographic studies have clarified the complex role of the glycoprotein gp120 in the early phase of
- Immunologic reconstitution by interleukin-2: facts and open questions.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):41-4. Unique Identifier : AIDSLINE MED/20224962
- Vallanti G; Bovolenta C; Brambilla A; Tambussi G; Lazzarin A; Vicenzi E; Poli G; AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute,; Milano, Italy.
- Interleukin-2 ( IL-2 ), one of the most potent immunoregulatory and inflammatory cytokines, is being tested in phase III clinical trials in order to demonstrate its efficacy in combination with current antiviral agents in preventing the occurrence of opportunistic infect
- Role of immune modulation in primary HIV infection.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):45-8. Unique Identifier : AIDSLINE MED/20224963
- Lori F; Lisziewicz J; Research Institute for Genetic and Human Therapy at I.R.C.C.S.; Policlinico S. Matteo, Pavia, Italy. right@gunet.georgetown.edu
- Hydroxyurea inhibits HIV without attacking the virus directly. By inhibiting a cellular enzyme (ribonucleotide reductase) the drug decreases the intracellular concentration of deoxynucleotide triphosphates, thus favoring the incorporation of other drugs, such as the reverse transcriptase inhibitors, into the nascent v
- Proposal for a national PHI register (NPHIR)
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):49-50. Unique Identifier : AIDSLINE MED/20224964
- Saracco A; EpiUnit, IRCCS, San Raffaele Scientific Institute, Milano, Italy.
- Prevalence of HIV-1 resistant strains in recent seroconverters.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):51-7. Unique Identifier : AIDSLINE MED/20224965
- Balotta C; Berlusconi A; Pan A; Violin M; Riva C; Gori A; Corvasce S; Mazzucchelli R; Facchi G; Velleca R; Senese D; Deho L; Galli M; Rusconi S; Moroni M; Institute of Infectious and Tropical Diseases, L. Sacco Hospital,; University of Milano, Italy. Claudia.Balotta@unimi.it
- Twenty-nine HIV-1 recently infected subjects were retrospectively studied to investigate both the prevalence of nucleoside reverse transcriptase inhibitors (NRTI)-related mutations at primary infection and the proportion of naturally occurring mutations in protease inhibitor (PI)-naive patients. Neither HIV-1 plasma v
- Four drug-HAART in primary HIV-1 infection: clinical benefits and virologic parameters.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):58-62. Unique Identifier : AIDSLINE MED/20224966
- Capiluppi B; Ciuffreda D; Quinzan GP; Sciandra M; Marroni M; Morandini B; Costigliola P; Guerra L; Di Pietro M; Fibbia GF; Visona R; Cusini M; Bressi C; Tambussi G; Lazzarin A; Department of Infectious Diseases, San Raffaele Scientific; Institute, Milano, Italy.
- BACKGROUND: From a theoretical standpoint, primary HIV infection (PHI) represents a great chance to modify the natural history of the disease. In this study we purposed a four drugs regimen with zidovudine, lamivudine, ritonavir and saquinavir to trea
- Primary HIV infection: molecular approaches in diagnosis and monitoring.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):63-7. Unique Identifier : AIDSLINE MED/20224967
- Ciuffreda D; Capiluppi B; Mastrorilli E; Balconi G; Tambussi G; Lazzarin A; Lillo F; Department of Infectious Diseases, San Raffaele Scientific; Institute, Milano, Italy.
- OBJECTIVE: The aim of this study was to evaluate, in patients with primary HIV infection (PHI), the modification of HIV molecular parameters (HIV, RNA, and DNA) induced by highly active antiretroviral therapy (HAART) in peripheral blood mononuclear cells (PBMC) and in lymphoid tissue (LNMC). METHODS: Nineteen patients
- Early production of HIV-1 neutralising antibodies in patients following highly active antiretroviral treatment (HAART) during primary HIV infection.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):68-74. Unique Identifier : AIDSLINE MED/20224968
- Barassi C; De Santis C; Pastori C; Marraccini P; Ciuffreda D; Capiluppi B; Bressi C; Siccardi AG; Lazzarin A; Tambussi G; Lopalco L; DIBIT and Infectious Disease Clinic, San Raffaele Scientific; Institute, Milano, Italy.
- We investigate the effects of highly active antiretroviral therapy (HAART) on humoral immune responses during a 24-month follow up of 15 HIV patients with acute primary HIV infection. The patients were divided into three groups on the basis of the therapeutic protocol they were following at the time of entry: a) five
- Viral dynamics and mutations in the pol gene during primary HIV-1 infection.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):7-10. Unique Identifier : AIDSLINE MED/20224954
- Cenci A; Bertoli A; Tambussi G; Menzo S; Clementi M; Lazzarin A; Capiluppi B; Ciuffreda D; Forbici F; Aquaro S; Marcuccilli F; Calio R; Perno CF; Department of Experimental Medicine, University Tor Vergata,; Roma, Italy.
- The understanding of viral dynamics and appearance of mutations during primary infection could be useful for the design of an efficient therapy. For this reason a cohort of samples from naive primary patients was examined. The results pointed out that only a few secondary mutations in protease gene (having no effect o
- Analysis of serum and plasma beta chemokines in primary HIV infection (PHI).
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):75-8. Unique Identifier : AIDSLINE MED/20224969
- Malnati MS; Tambussi G; Fischetti L; Algeri M; Veglia F; Capiluppi B; Lazzarin A; Lusso P; Human Virology Unit, San Raffaele Scientific Institute, Milano,; Italy.
- The levels of certain beta-chemokines in biological fluids do not necessarily reflect their circulating concentrations as they may be dramatically influenced by ex vivo release during sample manipulation. In the present study beta-chemochine levels were evaluated in sequential paired plasma and serum samples collected
- Cyclosporin A in combination with HAART in primary HIV-1 infection.
- J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):79-81. Unique Identifier : AIDSLINE MED/20224970
- Rizzardi GP; Vaccarezza M; Capiluppi B; Tambussi G; Lazzarin A; Pantaleo G; Department of Medicine, Centre Hospitalier Universitaire Vaudois,; University of Lausanne, Switzerland.; Paolo.Rizzardi@chuv.hospvd.ch
- HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also
- MLT and the immune-hematopoietic system.
- Adv Exp Med Biol. 1999;460:395-405. Unique Identifier : AIDSLINE MED/20270837
- Maestroni GJ; Istituto Cantonale di Patologia, Center for Experimental; Pathology, Locarno, Switzerland.
- It is now well recognized that a main actor in the continuous interaction between the nervous and immune systems is the pineal hormone MLT. T-helper cells bear G-protein coupled MLT cell membrane receptors and, perhaps, MLT nuclear receptors. Activation of MLT receptors enhances the release of T-helper cell type 1 (Th
- Identification and management of tuberculosis [see comments]
- Am Fam Physician. 2000 May 1;61(9):2667-78, 2681-2. Unique Identifier : AIDSLINE MED/20279169
- Jerant AF; Bannon M; Rittenhouse S; Department of Family and Community Medicine, University of; California, Davis, School of Medicine, California 95817, USA.
- Although the resurgence of tuberculosis in the early 1990s has largely been controlled, the risk of contracting this disease remains high in homeless persons, recent immigrants and persons infected with the human immunodeficiency virus (HIV). Purified protein derivative testing should be targeted at these groups and a
- Maine's Medicaid demonstration plan now covers early treatment for people who are HIV positive [news]
- Am J Nurs. 2000 May;100(5):21. Unique Identifier : AIDSLINE MED/20282567
- Benefits of screening for latent Mycobacterium tuberculosis infection.
- Arch Intern Med. 2000 May 22;160(10):1513-21. Unique Identifier : AIDSLINE MED/20284700
- Rose DN; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, NY 11040, USA. rose@lij.edu
- BACKGROUND: The benefits of screening for latent Mycobacterium tuberculosis infection are unknown for most people, because screening has not been studied in clinical trials and preventive therapy has not been tested in all risk groups for whom it is recommended. METHOD: A MEDLINE search was performed to determine tube
- Human immunodeficiency virus testing and behavior change [letter]
- Arch Intern Med. 2000 May 22;160(10):1538-9. Unique Identifier : AIDSLINE MED/20284704
- Weinhardt LS; Carey MP
- Induction of apoptosis and anti-HIV activity by tannin- and lignin-related substances.
- Basic Life Sci. 1999;66:595-611. Unique Identifier : AIDSLINE MED/20260259
- Sakagami H; Satoh K; Ida Y; Koyama N; Premanathan M; Arakaki R; Nakashima H; Hatano T; Okuda T; Yoshida T; Department of Dental Pharmacology, Meikai University School of; Dentistry, Saitama, Japan.
- Postexposure prophylaxis for HIV exposed health care workers.
- AAOHN J. 2000 Mar;48(3):148-51. Unique Identifier : AIDSLINE MED/20306336
- Robbins WA; School of Nursing and School of Public Health, University of; California, Los Angeles, USA.
- The role of Candida dubliniensis in oral candidiasis in human immunodeficiency virus-infected individuals.
- Crit Rev Microbiol. 2000;26(1):59-68. Unique Identifier : AIDSLINE MED/20244197
- Schorling SR; Kortinga HC; Froschb M; Muhlschlegel FA; Dermatologische Klinik und Poliklinik,; Ludwig-Maximilians-Universitat Munchen.; S.Schorling@lrz.uni-muenchen.de
- There is an increasing interest in non-albicans Candida species because of the increasing number of fungal infections they cause. Most of these infections can be found in immunocompromised individuals, especially in those infected with human immunodeficiency virus (HIV). Candida dubliniensis is a recently identified y
- Regulation of T cell function by NK cell receptors for classical MHC class I molecules.
- Curr Opin Immunol. 2000 Jun;12(3):295-300. Unique Identifier : AIDSLINE MED/20245258
- Ugolini S; Vivier E; Centre d'Immunologie de Marseille-Luminy (CIML), Institut; National de la Sante et de la Recherche Medicale; (INSERM)-Centre National de la Recherche Scientifique (CNRS),; Campus Universitaire de Luminy, Marseille, 13288, France.
- Inhibitory receptors for MHC class I molecules were initially characterised on NK cells. Human and mouse NK cell receptors (NKRs) are also expressed on T cells, predominantly on a subset of memory-phenotype CD8(+) T cells. This review focuses on the precise determination of interactions between NKRs and MHC class I, a
- Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.
- Curr Opin Immunol. 2000 Jun;12(3):323-9. Unique Identifier : AIDSLINE MED/20245262
- Trapani JA; Davis J; Sutton VR; Smyth MJ; The Research Division, The John Connell Laboratory, Peter; MacCallum Cancer Institute, St. Andrew's Place, Austin Research; Institute, Heidelberg, 3084, Australia.; j.trapani@pmci.unimelb.edu. au.
- Recent advances in our understanding of cytolytic effector mechanisms include the partial characterization of caspase-independent apoptotic pathways triggered by granzymes, a realization of the vital importance of perforin and granzymes in the defence against certain virus infections in vivo and the first description
- Expression of HLA-C-specific natural killer cell receptors (CD158a and CD158b) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation.
- Br J Haematol. 2000 Mar;108(4):778-83. Unique Identifier : AIDSLINE MED/20252780
- Tanaka J; Mori A; Ohta S; Yamamoto Y; Kobayashi S; Hashino S; Kobayashi M; Asaka M; Imamura M; Haematology and Oncology; Third Department of Internal Medicine;; Transfusion Medicine; Laboratory of Pathology, Cancer Institute,; Hokkaido University School of Medicine, Sapporo, Japan.; jtunaka@med.hokudai.ac.jp
- We investigated the expression of natural killer cell receptors (NKRs) for HLA-C on peripheral blood mononuclear cells (PBMCs) in 23 allogeneic bone marrow transplantation (allo-BMT) patients to analyse the role of NKRs in alloresponse concerning graft-versus-host disease (GVHD). CD158a expression was low and there wa
- Valine of the YVDD motif of moloney murine leukemia virus reverse transcriptase: role in the fidelity of DNA synthesis.
- Biochemistry. 2000 May 2;39(17):5155-65. Unique Identifier : AIDSLINE MED/20281817
- Kaushik N; Chowdhury K; Pandey VN; Modak MJ; Department of Biochemistry and Molecular Biology, Graduate School; of Biomedical Sciences and New Jersey Medical School, University; of Medicine and Dentistry of New Jersey, 185 South Orange Avenue,; Newark, New Jersey 07103, USA.
- The YXDD motif is highly conserved in the reverse transcriptase family. The variable X residue is occupied by valine and methionine in MuLV RT and HIV-1 RT, respectively. Previous studies have shown that Tyr 222, the Y residue of the YXDD motif in MuLV RT, constitutes a major component of the fidelity center of the en
- Regression of Epstein-Barr virus-associated lymphoproliferative disorders in patients with acquired immunodeficiency syndrome during therapy with foscarnet.
- Ann Hematol. 2000 Apr;79(4):214-6. Unique Identifier : AIDSLINE MED/20292343
- Schneider U; Ruhnke M; Delecluse HJ; Stein H; Huhn D; Charite Campus Virchow-Klinikum der Humboldt Universitat, Dept; of Medicine, Berlin, Germany.
- Epstein-Barr virus (EBV)-associated lymphoproliferative disorders frequently develop in patients with acquired immunodeficiency syndrome (AIDS). The lymphoproliferative disorders are usually treated with a combination of cytotoxic drugs, and virustatic medication is thought to be ineffective. However, we report about
- Chemokine receptor CCR5 and CXCR4 expression in HIV-associated kidney disease.
- J Am Soc Nephrol. 2000 May;11(5):856-67. Unique Identifier : AIDSLINE MED/20235205
- Eitner F; Cui Y; Hudkins KL; Stokes MB; Segerer S; Mack M; Lewis PL; Abraham AA; Schlondorff D; Gallo G; Kimmel PL; Alpers CE; Department of Pathology, University of Washington, Seattle,; Washington, USA.
- The chemokine receptors CCR5 and CXCR4 have been identified as essential coreceptors for entry of HIV-1 strains into susceptible cells. Direct infection of renal parenchymal cells has been implicated in the pathogenesis of HIV-associated renal disease, although data are conflicting. The localization of CCR5 and CXCR4
- Chemokine receptors and their role in inflammation and infectious diseases.
- Blood. 2000 May 15;95(10):3032-43. Unique Identifier : AIDSLINE MED/20269773
- Murdoch C; Finn A; Division of Child Health, University of Sheffield, Sheffield; Children's Hospital, Sheffield, United Kingdom.; c.murdoch@sheffield.ac.uk
- Chemokines are small peptides that are potent activators and chemoattractants for leukocyte subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7-transmembrane G-protein-coupled receptors, the size of which has grown considerably in recent years and now includes 18 members. Chemokin
- Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice.
- Blood. 2000 May 15;95(10):3085-93. Unique Identifier : AIDSLINE MED/20269780
- Barquinero J; Segovia JC; Ramirez M; Limon A; Guenechea G; Puig T; Briones J; Garcia J; Bueren JA; Department of Cell Therapy, Institut de Recerca Oncologica,; Barcelona, Spain.
- In an attempt to develop efficient procedures of human hematopoietic gene therapy, retrovirally transduced CD34(+) cord blood cells were transplanted into NOD/SCID mice to evaluate the repopulating potential of transduced grafts. Samples were prestimulated on Retronectin-coated dishes and infected with gibbon ape leuk
- Alteration of tumor necrosis factor-alpha T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome.
- Blood. 2000 May 15;95(10):3191-8. Unique Identifier : AIDSLINE MED/20269794
- Ledru E; Christeff N; Patey O; de Truchis P; Melchior JC; Gougeon ML; Unite d'Oncologie Virale, URA CNRS 1930, Departement SIDA et; Retrovirus, Institut Pasteur, Paris, France.
- Highly-active antiretroviral therapy (HAART) has lead to a dramatic decrease in the morbidity of patients infected with the human immunodeficiency virus (HIV). However, metabolic side effects, including lipodystrophy-associated (LD-associated) dyslipidemia, have been reported in patients treated with antiretroviral th
- [Importance of thalidomide in the treatment of cancer (news)]
- Bull Cancer. 2000 Apr;87(4):301-2. Unique Identifier : AIDSLINE MED/20313556
- Bay JO; Tournilhac O
- Shots in the desert and Gulf war syndrome. Evidence that multiple vaccinations during deployment are to blame is inconclusive [editorial; comment]
- BMJ. 2000 May 20;320(7246):1351-2. Unique Identifier : AIDSLINE MED/20279853
- Shaheen S
- Drug companies cut HIV drug prices in the developing world [news]
- BMJ. 2000 May 20;320(7246):1357. Unique Identifier : AIDSLINE MED/20279858
- Yamey G
- Primary effusion lymphoma cell lines harbouring human herpesvirus type-8.
- Leuk Lymphoma. 2000 Feb;36(5-6):447-56. Unique Identifier : AIDSLINE MED/20244974
- Carbone A; Cilia AM; Gloghini A; Capello D; Perin T; Bontempo D; Canzonieri V; Tirelli U; Volpe R; Gaidano G; Division of Pathology, Centro di Riferimento Oncologico, IRCCS,; Istituto Nazionale Tumori, Aviano, Italy. acarbone@ets.it
- Primary effusion lymphoma (PEL) is a novel lymphoma entity consistently infected by HHV-8 that occurs predominantly in immunodeficient patients and is characterized by liquid growth in the serous body cavities. In order to facilitate the understanding of PEL pathogenesis and histogenesis, we have established three PEL
- Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma.
- Cell Biol Int. 2000;24(4):195-209. Unique Identifier : AIDSLINE MED/20277978
- Gado K; Domjan G; Hegyesi H; Falus A; 1st Department of Internal Medicine, Haynal Imre University of; Health Sciences, Szabolcs utca 33-35, Budapest, H-1389, Hungary.
- Multiple myeloma (MM) is a currently incurable disease caused by the proliferation of malignant plasma cells. Although the pathogenesis of the disease still remains unclear, recent research in the biology of MM has produced new insights into the factors that control the growth and survival of myeloma cells. Among the
- Transcript imaging of the development of human T helper cells using oligonucleotide arrays.
- Nat Genet. 2000 May;25(1):96-101. Unique Identifier : AIDSLINE MED/20264377
- Rogge L; Bianchi E; Biffi M; Bono E; Chang SY; Alexander H; Santini C; Ferrari G; Sinigaglia L; Seiler M; Neeb M; Mous J; Sinigaglia F; Certa U; Roche Milano Ricerche, Milano, Italy. lars.rogge@roche.com
- Many pathological processes, including those causing allergies and autoimmune diseases, are associated with the presence of specialized subsets of T helper cells at the site of inflammation. Understanding the genetic program that controls the functional properties of T helper type 1 (Th1) versus T helper type 2 (Th2)
- Clinical update: new drugs for HIV/AIDS.
- Medsurg Nurs. 1999 Apr;8(2):108-12. Unique Identifier : AIDSLINE MED/99338163
- Gracia Jones S; Baggett TH; Mount Sinai Medical Center, Miami Beach, FL, USA.
- Monotherapy to treat the human immunodeficiency virus (HIV) is now a thing of the past. Combination drug therapies and several new anti-HIV drugs in clinical trials offer new promise for slowing the progress and deleterious effects of this disease.
- Leukocyte subsets in treatment-resistant major depression.
- Pol J Pharmacol. 1999 Nov-Dec;51(6):547-9. Unique Identifier : AIDSLINE MED/20275237
- Kubera M; Van Bockstaele D; Maes M; Department of Endocrinology, Institute of Pharmacology, Polish; Academy of Sciences, Krakow.
- Patients with treatment-resistant major depression had a significantly higher percentage of helper CD4+ T cells and immature double positive CD4+CD8+ T cells in their blood, and higher CD4+/CD8+ ratio than healthy controls. These results suggest activation of T helper immuno-response and disturbance in thymus function
- Time-dependence of survival predictions based on markers of HIV disease. Swiss HIV Cohort Study.
- J Investig Med. 2000 May;48(3):207-12. Unique Identifier : AIDSLINE MED/20282310
- Perneger TV; Abrahamowicz M; Bartlett G; Yerly S; Institute of Social and Preventive Medicine, University of Geneva; Medical School, Switzerland. thomas.perneger@hcuge.ch
- OBJECTIVE: To determine whether the ability of baseline clinical stage, viremia, and CD4 cell counts to predict mortality in HIV-1-infected patients changes with duration of follow-up. METHODS: Three hundred ninety-four patients were followed for an average of 29 months by the Swiss HIV Cohort Study, a practice-based
- Induction of transforming growth factor-beta 1 production in human cells by herpes simplex virus.
- J Interferon Cytokine Res. 2000 Mar;20(3):273-80. Unique Identifier : AIDSLINE MED/20222711
- Mendez-Samperio P; Hernandez M; Ayala HE; Departamento de Immunologia, Escuela Nacional de Ciencias; Biologicas, IPN, Carpio y Plan de Ayala, Mexico, D.F., Mexico.
- Transforming growth factor-beta (TGF-beta) is a cytokine of particular interest in human retrovirus infections because it can abrogate antigen-specific cellular activation. Although TGF-beta production has been observed in HIV infections, there is no evidence that herpes simplex virus (HSV)-stimulated human cells prod
- Coimmunization with IFN-gamma or IL-2, but not IL-13 or IL-4 cDNA can enhance Th1-type DNA vaccine-induced immune responses in vivo.
- J Interferon Cytokine Res. 2000 Mar;20(3):311-9. Unique Identifier : AIDSLINE MED/20222716
- Kim JJ; Yang JS; Montaner L; Lee DJ; Chalian AA; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.
- As we explore the potential improvements to the current DNA vaccine strategies, it may be desirable to investigate methods to improve the level of resulting immune responses. One strategy is the use of cytokine cDNA as molecular adjuvants for DNA-based vaccines. Codelivery of these molecular adjuvants consisting of ex
- Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection.
- Unique Identifier : AIDSLINE MED/20260542
- Romiti ML; Colognesi C; Cancrini C; Mas A; Berrino M; Salvatori F; Orlandi P; Jansson M; Palomba E; Plebani A; Bertran JM; Hernandez M; de Martino M; Amoroso A; Tovo PA; Rossi P; Espanol T; Scarlatti G; Division of Immunology and Infectious Diseases, Children's; Hospital Bambino Gesu, University of Rome Tor Vergata, Italy.
- BACKGROUND: A deletion of 32 base pairs in the CCR5 gene (delta32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults. MATERIALS AND METHODS: To determine the role of delta32 CCR5 in disease progression of HIV-1 infected children born to s
- UNAIDS releases long-awaited HIV vaccine guidelines [news]
- Nat Med. 2000 Apr;6(4):363. Unique Identifier : AIDSLINE MED/20207063
- Birmingham K
- $1 million study renews HIV/transplant research [news]
- Nat Med. 2000 Apr;6(4):365. Unique Identifier : AIDSLINE MED/20207066
- Wickware P
- Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract.
- Nat Med. 2000 Apr;6(4):475-9. Unique Identifier : AIDSLINE MED/20207097
- Collins KB; Patterson BK; Naus GJ; Landers DV; Gupta P; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pittsburgh,; Pennsylvania 15261, USA.
- [Aids neurologic manifestations in childhood]
- Rev Neurol. 1999 Aug 16-31;29(4):319-22. Unique Identifier : AIDSLINE MED/20258252
- Rotta NT; Silva C; Ohlweiler L; Lago I; Cabral R; Goncalves F; Almeida AM; Khan R; Mello L; Ranzan J; Guedes F
- INTRODUCTION: Children with AIDS get infected mainly by vertical transmission. DEVELOPMENT: That was what happened in 90% of the cases in a series of 340 HIV+ children followed at Hospital de Clinicas de Porto Alegre, Brazil . Currently, after the use of prophylactic treatment durin
- Biology and therapy of epidemic Kaposi's sarcoma.
- Cancer. 1987 Feb 1;59(3 Suppl):633-7. Unique Identifier : AIDSLINE MED/20281870
- Groopman JE; Division of Hematology/Oncology, New England Deaconess Hospital,; Boston, MA 02115, USA.
- Kaposi s sarcoma, once a rarely seen neoplasm in the West, now occurs in an epidemic fashion in association with acquired immune deficiency syndrome (AIDS). The pathogenesis of Kaposi s sarcoma is still unclear but it appears to be an endothelial neoplasm. Its clinical presentation may be quite subtle and varied. The
- Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon alfa-2a by intramuscular injection.
- Unique Identifier : AIDSLINE MED/20281876
- Itri LM; Campion M; Dennin RA; Palleroni AV; Gutterman JU; Groopman JE; Trown PW
- More than 1600 patients with neoplastic disorders have received recombinant human interferon alfa-2a (Roferon-A, Hoffmann-La Roche , Nutley, NJ) as part of ongoing or completed clinical trials. In this report, the efficacy of interferon alfa-2a therapy was compared with the incid
- Herpes simplex replication and dissemination is not increased by corticosteroid treatment in a rat model of focal Herpes encephalitis.
- J Neurovirol. 2000 Feb;6(1):25-32. Unique Identifier : AIDSLINE MED/20246675
- Thompson KA; Blessing WW; Wesselingh SL; Infectious Diseases Unit, School of Medicine, Monash University,; Victoria, Australia.
- Neurological damage in Herpes simplex type 1 encephalitis results from neuronal cell death secondary to viral invasion, and from inflammatory changes and cerebral oedema secondary to the immune response to the virus. Corticosteroids could have an important role in the management of Herpes simplex encephalitis because
- 1999 pioneer in neurovirology: Richard T Johnson, MD.
- Unique Identifier : AIDSLINE MED/20246673 P
- Etiology of microglial nodules in brains of patients with acquired immunodeficiency syndrome.
- J Neurovirol. 2000 Feb;6(1):46-50. Unique Identifier : AIDSLINE MED/20246677
- Nebuloni M; Pellegrinelli A; Ferri A; Tosoni A; Bonetto S; Zerbi P; Boldorini R; Vago L; Costanzi G; L. Sacco Institute of Biomedical Sciences, University of Milan,; L. Sacco Hospital, Italy.
- Microglial nodules associated with opportunistic and HIV-related lesions are frequently found in the brains of AIDS patients. However, in many cases, the causative agent is only presumptively suspected. We reviewed 199 brains of AIDS patients with micronodular lesions to clarify their etiology by immunohistochemistry
- Expression of complement inhibitor protein CD59 in human neuronal and glial cell lines treated with HIV-1 gp41 peptides.
- Unique Identifier : AIDSLINE MED/20246678
- Chong YH; Lee MJ
- In attempts to elucidate the pathogenic mechanisms involved in neurodegeneration in AIDS patients with cognitive deficits, the possible effect of HIV-1 transmembrane envelope protein gp41 on expression of the membrane inhibitor of complement mediated cytolysis (CD59) was assessed in human neuronal (SK-N-SH) and astrog
- High sensitivity detection of JC-virus DNA in postmortem brain tissue by in situ PCR.
- J Neurovirol. 2000 Feb;6(1):61-74. Unique Identifier : AIDSLINE MED/20246679
- Samorei IW; Schmid M; Pawlita M; Vinters HV; Diebold K; Mundt C; von Einsiedel RW; Department of Psychiatry, Ruprecht-Karls-Universitat,; Heidelberg, Germany.
- Opportunistic infection of the central nervous system by human polyomavirus JC can cause a devastating disease, progressive multifocal leukoencephalopathy (PML). To gain new neuropathological insights into JC-virus (JCV) infection patterns in PML at the light microscopic level, the highly sensitive indirect in situ po
- Upregulated expression of interleukin-8, RANTES and chemokine receptors in human astrocytic cells infected with HIV-1.
- J Neurovirol. 2000 Feb;6(1):75-83. Unique Identifier : AIDSLINE MED/20246680
- Cota M; Kleinschmidt A; Ceccherini-Silberstein F; Aloisi F; Mengozzi M; Mantovani A; Brack-Werner R; Poli G; AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milano, Italy.
- Human immunodeficiency virus (HIV) infection of the central nervous system (CNS) affects primarily microglial cells and astrocytes. Infection of these latter cells occurs independently of CD4 and is characterised by preferential accumulation of 2 Kb mRNA, encoding mostly Nef, and by low levels of 4.5 and 9 Kb RNAs. We
- Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors.
- J Neurovirol. 2000 Feb;6(1):84-8. Unique Identifier : AIDSLINE MED/20246681
- Sacktor NC; Skolasky RL; Lyles RH; Esposito D; Selnes OA; McArthur JC; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21224, USA.
- A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score
- Development of a novel (32)P-postlabeling method for the analysis of 3'-azido-3'-deoxythymidine.
- Cancer Lett. 2000 May 29;153(1-2):25-33. Unique Identifier : AIDSLINE MED/20243405
- Fang JL; Beland FA; Division of Biochemical Toxicology, National Center for; Toxicological Research, Jefferson, AR 72079, USA.; jfang@nctr.fda.gov
- 3 -Azido-3 -deoxythymidine ( AZT ) was the first anti-retroviral nucleoside analog to be used in the treatment and prevention of acquired immunodeficiency syndrome (AIDS). A novel (32)P-postlabeling assay, based upon thymidine kinase (TK) instead of the
- [Influence of insufficient zinc on immune functions in NIDDM patients]
- Hunan I Ko Ta Hsueh Hsueh Pao. 1998;23(6):599-601. Unique Identifier : AIDSLINE MED/20266745
- Wang P; Yang Z; Department of Endocrinology, Second Affiliated Hospital, Hunan; Medical University, Changsha.
- The serum zinc level and immune functions were analyzed in 34 patients with NIDDM before and after the treatment with zinc gluconate supplement during conventional therapy (after the blood glucose level stabilization). The results showed that before treatment the level of serum zinc and red cell C3b receptor rosette(R
- Recombinant adenovirus vaccine encoding a chimeric T-cell antigen receptor induces protective immunity against a T-cell lymphoma.
- Cancer Res. 2000 May 15;60(10):2689-95. Unique Identifier : AIDSLINE MED/20283289
- Wong CP; Levy R; Division of Oncology, Stanford University Medical Center,; California 94305, USA.
- Vaccination using recombinant tumor-derived T-cell antigen receptor (TCR) protein induces a protective, idiotype-specific immune response against a murine T-cell tumor. However, the technically demanding task of producing patient-specific, recombinant TCR protein restricts the translation of TCR vaccines for clinical
- Cooperativity of Staphylococcal aureus enterotoxin B superantigen, major histocompatibility complex class II, and CD80 for immunotherapy of advanced spontaneous metastases in a clinically relevant postoperative mouse breast cancer model.
- Unique Identifier : AIDSLINE MED/20283292 P
- Pulaski BA; Terman DS; Khan S; Muller E; Ostrand-Rosenberg S
- Multifunctional activity of recombinant p14 on lymphoid cell cultures.
- Cancer Detect Prev. 2000;24(1):46-52. Unique Identifier : AIDSLINE MED/20218048
- Pugliese A; Torre D; Cantamessa C; Saini A; Pes M; Savarino A; Department of Medical and Surgical Sciences, University of Turin,; Amedeo di Savoia Hospital, Torino, Italy. pugliese@dealer.it
- Some effects of recombinant p14, a protein encoded by the tat gene of immunodeficiency virus type 1 (HIV-1), were investigated on T lymphocytic cell cultures. In particular, we detected p14 adsorption to cells, the rate of cell replication, the expression of fibronectin (FN) and its receptor (FNR) and of cell surface
- Immune dysregulation as a cause for allergic asthma.
- Curr Opin Pulm Med. 1999 Jan;5(1):10-20. Unique Identifier : AIDSLINE MED/20271352
- Lipscomb MF; Wilder JA; Department of Pathology, University of New Mexico School of; Medicine, Albuquerque 87131-5301, USA.
- Allergic asthma is being increasingly understood as a disease caused by Th2-mediated immune responses to inhaled allergens. Most individuals fail to respond to allergens with a Th2 response, and thus, allergic asthma can be considered the result of an abnormally regulated or dysregulated immune response. The prevalenc
- TAP expression provides a general method for improving the recognition of malignant cells in vivo [see comments]
- Nat Biotechnol. 2000 May;18(5):515-20. Unique Identifier : AIDSLINE MED/20264173
- Alimonti J; Zhang QJ; Gabathuler R; Reid G; Chen SS; Jefferies WA; The Biotechnology Laboratory, Biomedical Research Centre,; Department of Medical Genetics, Microbiology and Immunology, and; Zoology, University of British Columbia, Vancouver, BC, Canada.
- A major class of tumors lack expression of the transporters associated with antigen processing (TAP). These proteins are essential for delivery of antigenic peptides into the lumen of the endoplasmic reticulum (ER) and subsequent assembly with nascent major histocompatibility complex (MHC) class I, which results in ce
- Adoptive transfer from interferon-alpha-fed mice is associated with inhibition of active experimental autoimmune encephalomyelitis by decreasing recipient tumor necrosis factor-alpha secretion.
- J Immunother. 2000 Mar-Apr;23(2):235-45. Unique Identifier : AIDSLINE MED/20208339
- Brod SA; Khan M; Nelson LD; Decuir B; Malone M; Henninger E; Department of Neurology and the Multiple Sclerosis Research; Group, University of Texas Health Science Center at Houston,; 77225, USA.
- Ingested type I interferon (IFN) suppresses clinical relapse in murine chronic experimental autoimmune encephalomyelitis (EAE), inhibits clinical attacks more effectively than subcutaneous doses, and decreases the adoptive transfer of EAE. To determine whether splenocytes from IFN-fed donors were suppressor-like pop
- Blood collecting resumes in Newfoundland community [news]
- CMAJ. 2000 May 16;162(10):1464. Unique Identifier : AIDSLINE MED/20293960
- Ryan B
- Health of children adopted from China.
- Pediatrics. 2000 Jun;105(6):E76. Unique Identifier : AIDSLINE MED/20295368
- Miller LC; Hendrie NW; International Adoption Clinic, Floating Hospital for Children,; New England Medical Center, Boston, MA 02111, USA.; laurie.miller@es.nemc.org
- OBJECTIVE: Since 1989, American parents have adopted 18 846 Chinese children. This study assesses the health and developmental status of these children after their arrival in the United States . PATIENTS AND METHODS: A total of 452 children (443 girls) in 2 groups were evaluated. The cl
- Gastrostomy tube insertion for improvement of adherence to highly active antiretroviral therapy in pediatric patients with human immunodeficiency virus.
- Unique Identifier : AIDSLINE MED/20295372
- Shingadia D; Viani RM; Yogev R; Binns H; Dankner WM; Spector SA; Chadwick EG
- OBJECTIVES: Newer combination antiretroviral therapies used to treat human immunodeficiency virus (HIV)-infected individuals have resulted in dramatic delays in HIV progression, with reduction in mortality and morbidity. However, adherence to highly active antiretroviral therapy (HAART) may be problematic, particularl
- A case of Penicillium marneffei infection in an AIDS patient: the first case in Japan.
- Nippon Ishinkin Gakkai Zasshi. 2000;41(1):23-6. Unique Identifier : AIDSLINE MED/20127991
- Mohri S; Yoshikawa K; Sagara H; Nakajima H; Department of Dermatology, Yokohama City Hospital, 56 Okazawacho,; Hodogaya-ku, Yokohama, Kanagawa 240-8555, Japan.
- A 38-year-old Japanese AIDS patient developed papular lesions which rapidly increased in number, eroded and crusted, and spread over not only skin but also the mucosal surface. High fever, sore throat, malaise and hepatosplenomegaly were also noted, and he died despite 2 months of intensive treatment. An autopsy revea
- Synthesis and biological activity of N-acylphenothiazines.
- Int J Antimicrob Agents. 2000 Apr;14(3):203-7. Unique Identifier : AIDSLINE MED/20238125
- Motohashi N; Kawase M; Saito S; Kurihara T; Satoh K; Nakashima H; Premanathan M; Arakaki R; Sakagami H; Molnar J; Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi,; Tokyo, Japan. motohasi@my-pharm.ac.jp
- Previous studies have demonstrated the relationship between radical intensity and cytotoxic activity in water-soluble compounds. This relationship was investigated in lipophilic compounds. Several N-acylphenothiazines showed higher cytotoxic activity against human leukemic and squamous carcinoma cell lines than phenot
- Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.
- Int J Antimicrob Agents. 2000 Apr;14(3):209-13. Unique Identifier : AIDSLINE MED/20238126
- Kristiansen JE; Hansen JB; Department of Clinical Microbiology, County of Sonderjylland,; 6400 Sonderborg, Sygehus, Denmark.
- A series of neuroleptic agents and their structural isomers have been tested as inhibitors of HIV-replication. At non-toxic concentrations, cis (Z)- and trans (E)-flupentixol and several derivatives of the 5HT-uptake-inhibitors paroxetine and femoxetine, inhibit HIV-1 replication. The findings indicated that these com
- Screening for anti-HIV drugs that can combine virucidal and virustatic activities synergistically.
- Int J Antimicrob Agents. 2000 Apr;14(3):215-20. Unique Identifier : AIDSLINE MED/20238127
- Chakrabarty AN; Mookerjee M; Dastidar SG; Department of Medical Microbiology and Parasitology, Calcutta; University College of Medicine, P.O.B. 16409, Calcutta, India.; madhabi@giascl.01.vsnl.net.in
- Chlorcyclizine HCl and ciprofloxacin HCl were shown to have anti-HIV activity. They possess virustatic and virucidal activities against HIV, a murine retrovirus (RV) and several other RNA and DNA viruses. These drugs were screened from a large number of compounds on the basis of in vitro mutagenicity and antimetabolit
- HTLV-I Tax and cell cycle progression.
- Prog Cell Cycle Res. 2000;4:157-62. Unique Identifier : AIDSLINE MED/20204996
- Neuveut C; Jeang KT; Laboratoire de Recombinaison et Expression Genetique, Institut; Pasteur, Paris, France.
- Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL) and various human myopathies/neuropathies. HTLV-I encodes a 40 kDa phosphoprotein, Tax, which has been implicated in cellular transformation. In similarity with several other oncoproteins such as Myc, Jun, and Fos, Tax
- Family planning perspectives at the beginning of the next century.
- Eur J Contracept Reprod Health Care. 1999 Dec;4(4):202-11. Unique Identifier : AIDSLINE MED/20274791
- Senanayake P; International Planned Parenthood Federation, London, UK.
- Looking back over the past 40 years or so, family planning has indeed been the success story of development; it has made an extraordinary difference to the lives of tens of millions of women. Globally speaking, the unmet needs for family planning and reproductive health still exist. Meeting these challenges would requ
- Reproductive and sexual health and safe motherhood in the developing world.
- Eur J Contracept Reprod Health Care. 1999 Dec;4(4):217-28. Unique Identifier : AIDSLINE MED/20274793
- Shah D; Shroff S; Sheth S; Nowrosjee Wadia Maternity Hospital, Mumbai, India.
- The aim of this paper is to discuss the main hurdles and possible solutions concerning reproductive and sexual health and safe motherhood in the developing countries. In response to the changing global situation, a broader new concept of reproductive health has emerged. The Programme of Action of The International Con
- The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly.
- Cell Death Differ. 2000 Jan;7(1):25-36. Unique Identifier : AIDSLINE MED/20180346
- Matarrese P; Conti L; Varano B; Gauzzi MC; Belardelli F; Gessani S; Malorni W; Department of Ultrastructures, Instituto Superiore di Sanita,; Viale Regina Elena, 299-00161 Rome, Italy.
- We have previously shown that CD4+ T Jurkat cells constitutively expressing low levels of the human immunodeficiency virus 1 (HIV-1) vpr protein were less susceptible to undergo apoptosis than control cells.1 In this study we have investigated the role of vpr in affecting mechanisms of importance in the control of apo
- Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive fas-mediated autocrine suicide of uninfected cells.
- Cell Death Differ. 2000 Jan;7(1):37-47. Unique Identifier : AIDSLINE MED/20180347
- Parlato S; Santini SM; Lapenta C; Spada M; Logozzi M; Rizza P; Proietti E; Belardelli F; Fais S; Laboratory of Virology, Istituto Superiore di Sanita, Viale; Regina Elena 299, 00161 Rome, Italy.
- We have recently shown that a human CD4+ T cell line (CEM-SS) acquires the permissiveness to M-tropic strains and primary isolates of HIV-1 after transplantation into SCID mice. This permissiveness was associated with the acquisition of a memory (CD45RO+) phenotype as well as of a functional CCR5 coreceptor. In this s
- Stopping poliovirus vaccination after eradication: issues and challenges [see comments]
- Unique Identifier : AIDSLINE MED/20272611
- Wood DJ; Sutter RW; Dowdle WR
- Since 1988 reported polio cases worldwide have declined by about 85% and the number of known or suspected polioendemic countries has decreased from over 120 to less than 50. With eradication of poliomyelitis approaching, issues potentially affecting when and how vaccination against poliovirus can be stopped become ext
- The risks of stopping vaccination: perspectives from the developing world.
- Bull World Health Organ. 2000;78(3):360-1. Unique Identifier : AIDSLINE MED/20272614
- Schoub BD; National Institute for Virology, South Africa.
- More partnerships to spur vaccine development [news]
- Bull World Health Organ. 2000;78(3):407. Unique Identifier : AIDSLINE MED/20272623
- Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT).
- Carcinogenesis. 2000 May;21(5):1059-62. Unique Identifier : AIDSLINE MED/20247110
- Bialkowska A; Bialkowski K; Gerschenson M; Diwan BA; Jones AB; Olivero OA; Poirier MC; Anderson LM; Kasprzak KS; Sipowicz MA; Intramural Research Support Program, SAIC-Frederick Inc.,; Frederick Cancer Research and Development Center (FCRDC),; Frederick, MD 21702, USA.
- The nucleoside analogue 3 -azido-3 -deoxythymidine ( AZT ) has been used successfully to reduce the incidence of transplacental and perinatal transmission of the HIV virus. However, prolonged treatment with high doses of AZT is utilized in this therapy,
- Progressive multifocal leukoencephalopathy: simultaneous detection of JCV DNA and anti-JCV antibodies in the cerebrospinal fluid.
- Eur J Neurol. 2000 Jan;7(1):101-6. Unique Identifier : AIDSLINE MED/20270614
- Guillaume B; Sindic CJ; Weber T; Laboratoire de Neurochimie, Universite Catholique de Louvain,; 53-59, Avenue Mounier, 1200 Bruxelles, Belgium.
- We report on a case of biopsy-proven progressive multifocal leukoencephalopathy (PML) in a patient without obvious immunodeficiency. Analysis of the cerebrospinal fluid revealed the simultaneous presence of JC virus DNA and of locally produced, anti-JC virus antibodies. The intrathecal humoral immune response increase
- Increased numbers of mononuclear cells from blood and CSF expressing interferon-gamma mRNA in multiple sclerosis are from both the CD4+ and the CD8+ subsets.
- Eur J Neurol. 2000 Jan;7(1):71-6. Unique Identifier : AIDSLINE MED/20270608
- Wallstrom E; Khademi M; Andersson M; Olsson T; Neuroimmunology Unit, Department of Medicine, Karolinska; Institute, Center of Molecular Medicine, L8:04, S-171 76; Stockholm, Sweden. erik.wallstrom@cmm.ki.se
- Activated, cytokine-producing lymphocytes may regulate central nervous system (CNS) inflammation in multiple sclerosis (MS). We utilize a novel combination of in situ hybridization (ISH) and immunocytochemical staining of peripheral blood lymphocytes (PBLs) to identify spontaneously interferon-gamma (IFNgamma) mRNA ex
- Sexual rights in southern Africa: a Beijing discourse or a strategic necessity?
- Health Hum Rights. 2000;4(2):144-73. Unique Identifier : AIDSLINE MED/20257141
- Klugman B; Women's Health Project, P.O. Box 1038, Johannesburg 2000, South; Africa.
- This article explores the meaning of sexual rights as interpreted by different stakeholders during the development of the Beijing Programme of Action and within the Southern African Development Community (SADC). It illustrates how the lack of sexual rights as understood in the African context results from poverty as w
- The 4th International AIDS Malignancy Conference. Bethesda, Maryland, USA. May 16-18, 2000. Abstracts.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):A1-37. Unique Identifier : AIDSLINE MED/20310653
- Inhibition of murine AIDS by alternate administration of azidothymidine and fludarabine monophosphate.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):209-20. Unique Identifier : AIDSLINE MED/20296466
- Fraternale A; Casabianca A; Tonelli A; Vallanti G; Chiarantini L; Brandi G; Celeste AG; Magnani M; Giorgio Fornaini Institute of Biologic Chemistry, University of; Urbino, Italy.
- Anti-HIV-1 combination therapies, including protease and reverse transcriptase inhibitors, can reduce plasma viremia to undetectable levels within the first 2 weeks of treatment. This reduction is followed by a slower decline that primarily results from the presence of viral reservoirs such as CD4+ memory cells, dendr
- Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):221-6. Unique Identifier : AIDSLINE MED/20296467
- Shulman NS; Zolopa AR; Passaro DJ; Murlidharan U; Israelski DM; Brosgart CL; Miller MD; Van Doren S; Shafer RW; Katzenstein DA; Stanford University School of Medicine, Division of Infectious; Diseases, California 94305, USA. nshulman@earthlink.net
- OBJECTIVE: To determine the impact of prior nonnucleoside reverse transcriptase inhibitor (NNRTI) therapy, genotypic resistance, and other variables on response to efavirenz (EFV)- and adefovir dipivoxil (ADV)-based salvage therapy. DESIGN: Retrospect
- Phase II placebo-controlled trial of fozivudine tidoxil for HIV infection: pharmacokinetics, tolerability, and efficacy.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):227-35. Unique Identifier : AIDSLINE MED/20296468
- Girard PM; Pegram PS; Diquet B; Anderson R; Raffi F; Tubiana R; Sereni D; Boerner D; Service des Maladies Infectieuses et Tropicales, Assistance; Publique-Hopitaux de Paris, Hopital Rothschild, France.; pierre-marie.girard@rth.ap-hop-paris.fr
- Fozivudine tidoxil (FZD) is a thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity demonstrated in vitro and in pilot phase I studies. To assess its safety, efficacy and pharmacokinetics, we conducted a multicenter, randomized, double-blind, placebo-controlled trial of FZD monotherapy in 72 HIV-infected p
- Incidence of adverse reactions in HIV patients treated with protease inhibitors: a cohort study. Coordinamento Italiano Studio Allergia e Infezione da HIV (CISAI) Group.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):236-45. Unique Identifier : AIDSLINE MED/20296469
- Bonfanti P; Valsecchi L; Parazzini F; Carradori S; Pusterla L; Fortuna P; Timillero L; Alessi F; Ghiselli G; Gabbuti A; Di Cintio E; Martinelli C; Faggion I; Landonio S; Quirino T; First Department of Infectious Diseases, L. Sacco Hospital,; Milan, Italy. paolo.bonfanti@tin.it
- OBJECTIVE: To assess the probability that protease inhibitor (PI) therapy might be discontinued because of adverse events (AE) and to evaluate the incidence rate of adverse reactions during PI treatment. DESIGN: A prospective cohort, multicenter study on HIV-positive patients starting treatment with at least one PI. S
- Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):246-54. Unique Identifier : AIDSLINE MED/20296470
- Fawzi WW; Msamanga G; Hunter D; Urassa E; Renjifo B; Mwakagile D; Hertzmark E; Coley J; Garland M; Kapiga S; Antelman G; Essex M; Spiegelman D; Department of Nutrition, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.
- BACKGROUND: Observational studies suggest that poor nutritional status among HIV-infected pregnant women is associated with a higher risk of vertical transmission of HIV. METHODS: We randomized 1083 pregnant women infected with HIV-1 in a double-blind, placebo-controlled trial to examine the effects of supplements of
- Dual nucleoside regimens in nonadvanced HIV infection: prospective follow-up of 130 patients, Aquitaine Cohort, 1996 to 1998. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine (GECSA).
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):255-60. Unique Identifier : AIDSLINE MED/20296471
- Morlat P; Marimoutou C; Dequae-Merchadou L; Pellegrin I; Mercie P; Neau D; Beylot J; Dabis F; Service de Medecine Interne et Maladies Infectieuses, Hopital; Saint-Andre, Centre Hospitalier Universitaire, Bordeaux, France.; philippe.morlat@chu-aquitaine.fr
- OBJECTIVE: To describe the response to combinations of two nucleoside reverse transcriptase inhibitors (NRTIs) initiated early in the course of HIV infection under routine circumstances and to research prognostic factors indicating good virologic response. SETTING: Patients of the Aquitaine Cohort, a hospital-based op
- Serum triglycerides, HIV infection, and highly active antiretroviral therapy, Aquitaine Cohort, France, 1996 to 1998. Groupe d'Epidemiologie Clinique du Sida en Aquitaine (GECSA).
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):261-5. Unique Identifier : AIDSLINE MED/20296472
- Thiebaut R; Dabis F; Malvy D; Jacqmin-Gadda H; Mercie P; ValentinVD; Unite INSERM 330, Universite Victor Segalen, Bordeaux, France.
- The aim of this study was to identify factors associated with serum triglyceride (TG) evolution in HIV-1-infected patients when highly active antiretroviral treatment (HAART) with or without protease inhibitors (PI) was introduced. Among 3191 patients of the Aquitai
- Combination therapies for HIV and sexual risk behavior among gay men.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):266-71. Unique Identifier : AIDSLINE MED/20296473
- Elford J; Bolding G; Maguire M; Sherr L; Department of Primary Care and Population Sciences and Royal Free; Centre for HIV Medicine, Royal Free and University College; Medical School, University College London, UK. elford@rfhsm.ac.uk
- OBJECTIVE: To examine optimism in the light of recent advances in HIV treatment among gay men and its association with sexual risk behavior. METHODS: An anonymous questionnaire was completed by gay men who visited gyms in central London in March and April 1998 regarding their HIV status, unprotected anal intercourse (
- Correlates of risky behaviors among young and older men having sexual relations with men in Montreal, Quebec, Canada. Omega Study Group.
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):272-8. Unique Identifier : AIDSLINE MED/20296474
- Dufour A; Alary M; Otis J; Noel R; Remis RS; Masse B; Parent R; Turmel B; Lavoie R; LeClerc R; Vincelette J; Groupe de Recherche en Epidemiologie de l'Universite Laval,; Centre Hospitalier Affilie Universitaire de Quebec, Quebec,; Canada.
- OBJECTIVE: To assess characteristics associated with 1) age and 2) recent unprotected anal sex with casual partners among men having sexual relations with men (MSM) participating in the Omega Cohort, Montreal, Quebec, Canada . METHODS: The Omega Cohort is a study of the incidence an
- Emergence of zidovudine resistance in HIV-infected patients receiving stavudine [letter]
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):279-81. Unique Identifier : AIDSLINE MED/20296475
- de Mendoza C; Soriano V; Briones C; Gallego O; Barreiro P; Alvarez A; Gonzalez-Lahoz J
- Evaluation of three rapid/simple tests for detection of HIV-2 antibodies [letter]
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):281-3. Unique Identifier : AIDSLINE MED/20296476
- Malone JD; Sheffield J; Tribble D; Lowe-Bey F; Cannon M; Slaughter-Allen M; Brown AE; Kanki PJ
- Persistent human herpesvirus 8 viremia associated with coinfection with human T-cell lymphotropic virus type I and myelofibrosis [letter]
- J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):283-6. Unique Identifier : AIDSLINE MED/20296477
- Engels EA; Eastman H; Ablashi DV; Wilks RJ; Braham J; Manns A
- Experimental conditions that increase the production of HIV-1 by monocyte-derived macrophages: use of collagen matrix.
- Microbes Infect. 1999 Aug;1(10):765-70. Unique Identifier : AIDSLINE MED/20273593
- Godard CM; Chermann JC; Inserm Unite 322, Parc Scientifique et Technologique de Luminy,; Marseille, France.
- Monocyte-derived macrophages (MDMs) from healthy blood donors were isolated by adherence to tissue culture-treated plasticware. They were cultured in vitro in medium supplemented with human serum and recombinant GM-CSF, then infected with the macrophage-tropic prototype strain HIV-1-PAR. Virus production was quantitat
- Increase in CD3+ CD4- T lymphocytes in patients with AIDS and disseminated Mycobacterium avium-intracellulare complex infection: a prospective study. GECSA. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine.
- Microbes Infect. 1999 Aug;1(10):771-6. Unique Identifier : AIDSLINE MED/20273594
- Bonnet F; Dequae-Merchadou L; Taupin JL; Sire S; Dupon M; Ragnaud JM; Lacoste D; Texier-Maugein J; Romagne F; Dabis F; Pellegrin JL; Moreau JF; Service de medecine interne et maladies infectieuses, Hopital; du Haut-Leveque, CHU Bordeaux, France.
- In a retrospective study, an increase in double-negative (CD3+ CD4- CD8-) (DN) T lymphocytes has been shown to be an independent predictor of disseminated Mycobacterium avium complex (D.MAC) infection in patients with less than 100 CD4+ T cells per mm3. To better characterize this cell expansion, a prospective study w
- Molecular epidemiology, pathogenesis, and genetics of the dimorphic fungus Histoplasma capsulatum.
- Microbes Infect. 1999 Aug;1(10):817-25. Unique Identifier : AIDSLINE MED/20273599
- Retallack DM; Woods JP; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison 53706, USA.
- Histoplasma capsulatum, the causative agent of the most common systemic fungal infection, histoplasmosis, has become subject to increasing study in parallel with rising prevalence of human immunodeficiency. This review presents a summary of the advances made in the investigation of H. capsulatum genomics, molecular ep
- Search for an antibody profile of Rhodococcus equi infection in AIDS patients despite the diversity of isolates and patient immune dysfunction.
- Unique Identifier : AIDSLINE MED/20079441
- Caterino-De-Araujo A; de Los Santos-Fortuna E; Zandona-Meleiro MC; Mastroianni CM; Lichtner M; Mengoni F; Vullo V; Immunology Department, Instituto Adolfo Lutz, Secretary of Health; of Sao Paulo, SP, Brazil.
- Diversity of virulence-associated antigens of Rhodococcus equi was detected among thirteen strains isolated from AIDS patients on two continents. One out of four Brazilian isolates presented the virulence-associated antigen of 15- to 17-kDa, and the other three isolates had the 20-kDa virulence-associated antigen. In
- Cell-dependent replication potentials of HIV-1 gag mutants.
- Microbes Infect. 1999 Jul;1(9):671-6. Unique Identifier : AIDSLINE MED/20079442
- Adachi A; Tamaki M; Shimano R; Inubushi R; Naito T; Yoshida K; Oshima Y; Kawamura M; Koyama AH; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.
- An infectious molecular clone of human immunodeficiency virus type 1 (HIV-1), designated pNLaiKH, which is tropic for both lymphocytic and monocytic cells, was constructed. To study the early function of HIV-1 Gag proteins in two types of cells, the mutations known to give host cell-dependent early defects were introd
- Isolation and characterization of a monoclonal antibody that inhibits HIV-1 infection.
- Microbes Infect. 1999 Jul;1(9):677-84. Unique Identifier : AIDSLINE MED/20079443
- Fu DX; Jinno A; Shimizu N; Haraguchi Y; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Showa-machi, Maebashi, Gunma 371, Japan.
- To identify a cell surface molecule other than CD4 involved in infection of cultured cells with human immunodeficiency virus type 1 (HIV-1), mice were immunized with the CD4-negative Raji human B-cell line in order to isolate a monoclonal antibody (mAb). We isolated mAb 33A, which inhibited the infection of CD4-positi
- Assessing virologic efficacy of combination lamivudine and low-dose hepatitis B immune globulin posttransplantation with the ultrasensitive digene hybrid capture II assay [letter]
- Liver Transpl. 2000 May;6(3):386. Unique Identifier : AIDSLINE MED/20310650
- Yoshida EM; Sherlock CH
- Role of the CDC in hemodialysis: an historical perspective.
- Semin Dial. 2000 Mar-Apr;13(2):64-7. Unique Identifier : AIDSLINE MED/20255666
- Favero MS; Johnson & Johnson, Irvine, California, USA. msfavero@aol.com
- National surveillance of dialysis-associated diseases in the United States, 1997.
- Semin Dial. 2000 Mar-Apr;13(2):75-85. Unique Identifier : AIDSLINE MED/20255669
- Tokars JI; Miller ER; Alter MJ; Arduino MJ; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA. jit1@cdc.gov
- Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin mannich bases.
- Eur J Med Chem. 2000 Feb;35(2):249-55. Unique Identifier : AIDSLINE MED/20223977
- Pandeya SN; Sriram D; Nath G; De Clercq E; Department of Pharmaceutics, Institute of Technology, Banaras; Hindu University, Varanasi, India. snpande@banaras.ernet.in
- Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. Their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analysis. Investigation of in vitro antimicrobial activity of compounds was done by the agar dilution method
- Reducing perinatal transmission of HIV: early diagnosis and interventions during pregnancy.
- J Midwifery Womens Health. 2000 Mar-Apr;45(2):122-9. Unique Identifier : AIDSLINE MED/20272737
- Stein E; Handelsman E; Matthews R; State University of New York Health Science Center at Brooklyn,; USA.
- This article reviews the New York State regulations regarding expedited testing of newborns for exposure to HIV. Included is a review of statistics as well as the medical and obstetric management of HIV positive pregnant women, including route of delivery. The professional responsibility of midwives, physicians, and o
- HIV in older Americans: an epidemiologic perspective.
- J Midwifery Womens Health. 2000 Mar-Apr;45(2):176-82. Unique Identifier : AIDSLINE MED/20272743
- Lieberman R; State University of New York (SUNY) Health Science Center at; Brooklyn, USA.
- The elderly population is increasing as baby boomers are beginning to approach retirement. People 65 years of age or older already constitute approximately one eighth of the U.S. population; this proportion is expected to double in the next 50 years. Older Americans have their own population-specific health challenges
- [The changes of serum estrogen, progesterone and the function of immune system in intrahepatic cholestasis of pregnancy]
- Chung Hua Fu Chan Ko Tsa Chih. 1998 Dec;33(12):724-6. Unique Identifier : AIDSLINE MED/20266623
- Shi Q; Liu S; Xiong Q; Second University Hospital, West China University of Medical; Sciences, Chengdu.
- OBJECTIVE: To explore the effects of estrogen, progesterone and the function of immune system on intrahepatic cholestasis of pregnancy (ICP). METHODS: Fifty women with ICP and fifty normal pregnant women were enrolled in the study. The levels of their serum estradiol (E2) and progesterone (P) were measured and cellula
- [Determination of cellular and humoral immunity in mice of autoimmune ovarian failure]
- Chung Hua Fu Chan Ko Tsa Chih. 1998 Dec;33(12):735-6. Unique Identifier : AIDSLINE MED/20266626
- Lin J; Yan J; Lin Q; Renji Hospital, Shanghai Second Medical University.
- OBJECTIVE: To determine cellular and humoral immunity in mice of autoimmune ovarian failure. METHODS: A mice model of autoimmune ovarian failure was established. The percentages of help T cell (CD4+) and suppressor T cell (CD8+), the ratio of CD4/CD8 and anti-ovarian antibody (AOA) were determined. RESULTS: No signifi
- Analyses of quality assessment studies using CD45 for gating lymphocytes for CD3(+)4(+)%.
- Cytometry. 2000 Feb 15;42(1):1-4. Unique Identifier : AIDSLINE MED/20145727
- Gelman R; Wilkening C; Biostatistics Department, Harvard School of Public Health,; Boston, Massachusetts, USA. gelman@jimmy.harvard.edu
- BACKGROUND: The purpose of this study was to assess whether laboratories which do not use CD45 for gating lymphocytes with three- (or four-) color flow cytometry (non-CD45 laboratories) for CD3(+)4(+)% and CD3(+)8(+)% do worse on quality assessment (QA) studies than laboratories which do use CD45 (CD45 laboratories).
- Detection of apoptotic T lymphocytes in peripheral blood of human immunodeficiency virus (HIV)-infected subjects by apostain.
- Cytometry. 2000 Feb 15;42(1):67-73. Unique Identifier : AIDSLINE MED/20145736
- Kunkl A; Paola Terranova M; Ferlini C; Astegiano G; Mazzarello G; Scambia G; Fattorossi A; Department of Immunology, San Martino Hospital and University of; Genoa, Genoa, Italy.
- Apoptosis has been indicated as a mechanism of T cell depletion in HIV-infected subjects and useful in monitoring disease progression. We investigated for the presence of apoptotic T lymphocytes in 130 HIV subjects in various stages of disease by the newly developed cell permeant DNA dye Apostain. Blood was collected
- CD4 count/viral load in HIV.
- Cytometry. 2000 Feb 15;42(1):79-80. Unique Identifier : AIDSLINE MED/20145738
- Hengel R; Georgetown University, Washington, D.C, USA.
- Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif.
- Eur J Biochem. 2000 Apr;267(8):2419-31. Unique Identifier : AIDSLINE MED/20223278
- Daviet L; Erard M; Dorin D; Duarte M; Vaquero C; Gatignol A; U332 INSERM, U529 INSERM, Institut Cochin de Genetique; Moleculaire, Paris, France.
- Double-stranded RNA-binding proteins constitute a large family with conserved domains called dsRBDs. One of these, TRBP, a protein that binds HIV-1 TAR RNA, has two dsRBDs (dsRBD1 and dsRBD2), as indicated by computer sequence homology. However, a 24-amino-acid deletion in dsRBD2 completely abolishes RNA binding, sugg
- Fidelity analysis of HIV-1 reverse transcriptase mutants with an altered amino-acid sequence at residues Leu74, Glu89, Tyr115, Tyr183 and Met184.
- Eur J Biochem. 2000 May;267(9):2658-65. Unique Identifier : AIDSLINE MED/20247166
- Jonckheere H; De Clercq E; Anne J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
- Substitution of particular residues postulated to have a role in active site architecture can alter the overall fidelity of DNA polymerization by HIV-1. The effects of this kind of substitution were determined in a lacZ-based assay using HIV-1 reverse transcriptase with specifically mutated residues. We found that the
- The HIV-1(Lai) RNA dimerization. Thermodynamic parameters associated with the transition from the kissing complex to the extended dimer.
- Eur J Biochem. 2000 May;267(9):2711-9. Unique Identifier : AIDSLINE MED/20247173
- Theilleux-Delalande V; Girard F; Huynh-Dinh T; Lancelot G; Paoletti J; Centre de Biophysique Moleculaire, UPR 4301 CNRS conventionnee; avec l'Universite d'Orleans, Orleans, France.
- Retroviruses contain dimeric RNA consisting of two identical copies of the genomic RNA. The interaction between these two RNA molecules occurs near their 5 ends. A region upstream from the splice donor comprising an auto-complementary sequence has been identified as being responsible for the initiation of the formati
- Study of HIV-2 primer-template initiation complex using antisense oligonucleotides.
- Eur J Biochem. 2000 May;267(9):2803-11. Unique Identifier : AIDSLINE MED/20247182
- Boulme F; Freund F; Gryaznov S; Nielsen PE; Tarrago-Litvak L; Litvak S; UMR 5097 CNRS-Universite Victor Segalen Bordeaux 2, IFR 66; 'Pathologies Infectieuses', Bordeaux, France.
- HIV-2 reverse transcription is initiated by the retroviral DNA polymerase (reverse transcriptase) from a cellular tRNALys3 partially annealed to the primer binding site in the 5 -region of viral RNA. The HIV-2 genome has two A-rich regions upstream of the primer binding site. In contrast to HIV-1 RNA, no direct eviden
- Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group.
- Eur J Clin Microbiol Infect Dis. 2000 Feb;19(2):89-95. Unique Identifier : AIDSLINE MED/20208282
- Podzamczer D; Miro JM; Ferrer E; Gatell JM; Ramon JM; Ribera E; Sirera G; Cruceta A; Knobel H; Domingo P; Polo R; Leyes M; Cosin J; Farinas MC; Arrizabalaga J; Martinez-Lacasa J; Gudiol F; Infectious Disease Service, Ciutat Sanitaria de Bellvitge,; c/Feixa Llarga s/n. L'Hospitalet, Barcelona, Spain.; dpodzamczer@csub.scs.es
- An open, randomised, multicentre trial was conducted to evaluate the efficacy of thrice-weekly versus daily therapy with sulfadiazine-pyrimethamine in the prevention of relapses of toxoplasmic encephalitis in HIV-infected patients. Between February 1994 and July 1997, 124 patients with HIV infection were enrolled afte
- Risk factors for esophageal candidiasis.
- Eur J Clin Microbiol Infect Dis. 2000 Feb;19(2):96-100. Unique Identifier : AIDSLINE MED/20208283
- Chocarro Martinez A; Galindo Tobal F; Ruiz-Irastorza G; Gonzalez Lopez A; Alvarez Navia F; Ochoa Sangrador C; Martin Arribas MI; Department of Internal Medicine, Hospital Virgen de la Concha,; Zamora, Spain. achocarrom@medynet.com
- The role of gastric acid inhibitors as predisposing factors for Candida esophagitis is unknown. A retrospective case-control study of esophageal candidiasis was conducted in human immunodeficiency virus (HIV)-negative patients diagnosed from January 1991 to December 1997. The diagnosis of esophageal candidiasis was al
- Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus-afflicted mice.
- Exp Gerontol. 2000 Mar;35(2):225-36. Unique Identifier : AIDSLINE MED/20231693
- Dayan M; Segal R; Globerson A; Habut B; Shearer GM; Mozes E; Department of Immunology, The Weizmann Institute of Science,; Rehovot, Israel.
- Aging mice of strains susceptible to the induction of experimental systemic lupus erythematosus (SLE) develop a milder disease than young animals. To find out whether the decrease in susceptibility to disease is due to age-associated changes in cytokine profile, we first examined the secretion of cytokines by healthy
- Immune dysfunction despite high levels of immunoregulatory cytokine gene expression in autologous peripheral blood stem cell transplanted non-Hodgkin's lymphoma patients.
- Exp Hematol. 2000 May;28(5):499-507. Unique Identifier : AIDSLINE MED/20273828
- Singh RK; Varney ML; Ino K; Vose JM; Bierman PJ; Talmadge JE; Department of Pathology and Microbiology, and, University of; Nebraska Medical Center, Omaha, Nebraska, USA. rsingh@unmc.edu
- OBJECTIVE: In the present studies, we examined the role of immunoregulatory cytokine gene expression in immune reconstitution following high-dose chemotherapy and peripheral stem cell transplantation. MATERIALS AND METHODS: We analyzed the steady-state mRNA cytokine levels and the immune phenotype and function in the
- Differential engraftment of genetically modified CD34(+) and CD34(-) hematopoietic cell subsets in lethally irradiated baboons.
- Exp Hematol. 2000 May;28(5):508-18. Unique Identifier : AIDSLINE MED/20273829
- Andrews RG; Peterson LJ; Morris J; Potter J; Heyward S; Gough M; Bryant E; Kiem H; Division of Clinical Research, Fred Hutchinson Cancer Research; Center, the Departments of, Seattle, WA 98109-1024, USA.; randrews@fhcrc.org
- OBJECTIVE: To test gibbon ape leukemia virus (GALV) pseudotype vector transduction of marrow subpopulations that contribute to hematopoietic reconstitution in vivo. MATERIALS AND METHODS: Autologous CD34(+) Lin(-), CD34(+) Lin(+), and CD34(-) Lin(-) marrow cells, transduced by coculture with PG13/LN, PG13/LNX, and PG1
- Hepatitis C virus, hepatitis B virus and human immunodeficiency virus infection in pregnant women in North-East Italy: a seroepidemiological study.
- Eur J Epidemiol. 2000 Jan;16(1):87-91. Unique Identifier : AIDSLINE MED/20241260
- Baldo V; Floreani A; Menegon T; Grella P; Paternoster DM; Trivello R; Institute of Hygiene, University of Padua, Italy.
- BACKGROUND: Pregnant women can be considered a sentinel population, because they are a relatively unselected population whose prevalence data may be extended to the general population. METHODS: A seroepidemiological study was carried out in Padua (North-East Italy ) to assess the epi
- The pathology of human West Nile Virus infection.
- Hum Pathol. 2000 May;31(5):527-31. Unique Identifier : AIDSLINE MED/20294280
- Sampson BA; Ambrosi C; Charlot A; Reiber K; Veress JF; Armbrustmacher V; Office of Chief Medical Examiner of the City of New York, NY; 10016, USA.
- West Nile Virus (WNV) was identified by immunohistochemistry (IHC) and polymerase chain reaction (PCR) as the etiologic agent in 4 encephalitis fatalities in New York City in the late summer of 1999. The fatalities occurred in persons with a mean age of 81.5 years, each of whom had underlying medical problems. Cardina
- Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondii.
- Infect Immun. 2000 May;68(5):2713-9. Unique Identifier : AIDSLINE MED/20231809
- Collazo CM; Miller C; Yap G; Hieny S; Caspar P; Schwartz RH; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, Maryland 20892, USA. CCOLLAZO@niaid.nih.gov
- Resistance to Toxoplasma gondii has been shown to be mediated by gamma interferon (IFN-gamma) produced by NK, CD4(+), and CD8(+) T cells. While studies of SCID mice have implicated NK cells as the source of the cytokine in acute infection, several lines of evidence suggest that IFN-gamma production by CD4(+) T lymphoc
- In situ analysis of the evolution of the primary immune response in murine Chlamydia trachomatis genital tract infection.
- Infect Immun. 2000 May;68(5):2870-9. Unique Identifier : AIDSLINE MED/20231829
- Morrison SG; Morrison RP; Department of Microbiology, Montana State University, Bozeman,; Montana 59717, USA.
- Adaptive immune responses contribute to the resolution of Chlamydia trachomatis genital tract infection and protect against reinfection, but our understanding of the mechanisms of those protective responses is incomplete. In this study, we analyzed by in situ immunohistochemistry the progression of the inflammatory an
- Invasion of the brain and chronic central nervous system infection after systemic Mycobacterium avium complex infection in mice.
- Infect Immun. 2000 May;68(5):2979-84. Unique Identifier : AIDSLINE MED/20231843
- Wu HS; Kolonoski P; Chang YY; Bermudez LE; Kuzell Institute for Arthritis and Infectious Disease, San; Francisco, California 94115, USA.
- Central nervous system (CNS) infections caused by nontuberculous mycobacteria have been described previously, especially in patients with AIDS. To investigate specific aspects of the pathogenesis of this entity, C57BL bg(+)/bg(-) mice were infected intravenously with Mycobacterium avium, and cultures of blood and brai
- Cutaneous manifestations of marantic endocarditis.
- Int J Dermatol. 2000 Apr;39(4):290-2. Unique Identifier : AIDSLINE MED/20270085
- Kimyai-Asadi A; Usman A; Milani F; Ronald O. Perelman Department of Dermatology, New York University; School of Medicine, New York, NY, USA.
- A 70-year-old patient with a history of hypertension and hypercholesterolemia was referred for evaluation of necrotic toes. The patient had a history of several cerebrovascular accidents during the previous month. Initially, she developed sudden-onset left upper extremity weakness which, over the ensuing 4 days, progr
- Cytomegalovirus retinitis in the era of highly active antiretroviral therapy.
- Int Ophthalmol Clin. 2000 Spring;40(2):127-35. Unique Identifier : AIDSLINE MED/20251857
- Zegans M; Marsh B; Walton RC; Section of Ophthalmology, Dartmouth-Hitchcock Medical Center,; Lebanon, NH 03756, USA.
- In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation.
- Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1803-11. Unique Identifier : AIDSLINE MED/20302224
- Kezuka T; Streilein JW; Schepens Eye Research Institute, Department of Ophthalmology,; Harvard Medical School, Boston, Massachusetts 02114, USA.
- PURPOSE: When injected intravenously into naive mice, peritoneal exudate cells (PECs) incubated with ovalbumin (OVA) in the presence of transforming growth factor (TGF)-beta2 induce immune deviation similar to that evoked by injection of OVA into the anterior chamber of the eye. Intraocular antigen injection elicits t
- Proving HIV-1 immunity: new tools offer new opportunities [comment]
- J Clin Invest. 2000 May;105(10):1333-4. Unique Identifier : AIDSLINE MED/20273922
- Picker LJ; Vaccine and Gene Therapy Institute, Oregon Health Sciences; University, Mail Code: L220, 3181 SWSam Jackson Park Road,; Portland, Oregon 97201-3098, USA. pickerl@ohsu.edu
- HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death [see comments]
- J Clin Invest. 2000 May;105(10):1407-17. Unique Identifier : AIDSLINE MED/20273932
- Brodie SJ; Patterson BK; Lewinsohn DA; Diem K; Spach D; Greenberg PD; Riddell SR; Corey L; Department of Laboratory Medicine, University of Washington,; Seattle, Washington 98195, USA. sjbrodie@u.washington.edu
- We have tracked the in vivo migration and have identified in vivo correlates of cytotoxic T-lymphocyte (CTL) activity in HIV-seropositive subjects infused with autologous gene-marked CD8(+) HIV-specific CTL. The number of circulating gene-marked CTL ranged from 1.6 to 3.5% shortly after infusion to less than 0.5% 2 we
- Antiviral therapy of HBV- and HCV-induced liver cirrhosis.
- J Clin Gastroenterol. 2000 Apr;30(3):234-41. Unique Identifier : AIDSLINE MED/20236937
- Zavaglia C; Airoldi A; Pinzello G; Divisione di Medicina Generale Crespi, Ospedale Niguarda, Milano,; Italy.
- Antiviral therapy is generally indicated in patients who have histologic evidence of chronic hepatitis and ongoing viral replication. The aim of treatment is to normalize alanine aminotransferase levels and to eliminate virus replication. Interferon-alfa (IFN-alpha) is the most used agent. The standard treatment regim
- Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo.
- J Exp Med. 2000 May 15;191(10):1661-74. Unique Identifier : AIDSLINE MED/20273973
- d'Ostiani CF; Del Sero G; Bacci A; Montagnoli C; Spreca A; Mencacci A; Ricciardi-Castagnoli P; Romani L; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, 06122 Perugia,; Italy.
- The fungus Candida albicans behaves as a commensal as well as a true pathogen of areas highly enriched in dendritic cells, such as skin and mucosal surfaces. The ability of the fungus to reversibly switch between unicellular yeast to filamentous forms is thought to be important for virulence. However, whether it is th
- Incomplete CD8(+) T lymphocyte differentiation as a mechanism for subdominant cytotoxic T lymphocyte responses to a viral antigen.
- J Exp Med. 2000 May 15;191(10):1687-98. Unique Identifier : AIDSLINE MED/20273975
- Spencer JV; Braciale TJ; Beirne B. Carter Center for Immunology Research, University of; Virginia, Charlottesville, Virginia 22906, USA.
- CD8(+) cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. Class I epitopes have been classified as dominant or subdominant depending on the magnitude of the CTL response to the epitope. In this report, we have examined the in vitro memory CTL re
- A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock.
- J Exp Med. 2000 May 15;191(10):1755-64. Unique Identifier : AIDSLINE MED/20273981
- Chvatchko Y; Hoogewerf AJ; Meyer A; Alouani S; Juillard P; Buser R; Conquet F; Proudfoot AE; Wells TN; Power CA; Serono Pharmaceutical Research Institute, 1228; Plan-les-Ouates/Geneva, Switzerland. yolande.chvatchko@serono.com
- CC chemokine receptor (CCR)4, a high affinity receptor for the CC chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC), is expressed in the thymus and spleen, and also by peripheral blood T cells, macrophages, platelets, and basophils. Recent studies have shown that CCR4 i
- Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.
- J Exp Med. 2000 May 15;191(10):1777-88. Unique Identifier : AIDSLINE MED/20273983
- Santini SM; Lapenta C; Logozzi M; Parlato S; Spada M; Di Pucchio T; Belardelli F; Laboratory of Virology, Istituto Superiore di Sanita, 00161; Rome, Italy.
- Type I interferons (IFNs) are cytokines exhibiting antiviral and antitumor effects, including multiple activities on immune cells. However, the importance of these cytokines in the early events leading to the generation of an immune response is still unclear. Here, we have investigated the effects of type I IFNs on fr
- Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system [see comments]
- J Exp Med. 2000 May 15;191(10):1799-806. Unique Identifier : AIDSLINE MED/20273985
- Villoslada P; Hauser SL; Bartke I; Unger J; Heald N; Rosenberg D; Cheung SW; Mobley WC; Fisher S; Genain CP; Department of Neurology, University of California at San; Francisco, San Francisco, California 94143-0435, USA.
- Multiple sclerosis is a demyelinating disorder of the central nervous system (CNS), in which an immune attack directed against myelin constituents causes myelin destruction and death of oligodendrocytes, the myelin-producing cells. Here, the efficacy of nerve growth factor (NGF), a growth factor for neurons and oligod
- Cytokine profile of draining lymph node lymphocytes in mice grafted with syngeneic keratinocytes expressing human papillomavirus type 16 E7 protein.
- J Gen Virol. 2000 May;81 Pt 5:1175-82. Unique Identifier : AIDSLINE MED/20231926
- Lopez MC; Stanley MA; Department of Pathology, University of Cambridge, UK.
- Studies on the immune response to human papillomaviruses are compromised by the extreme host and tissue specificity of these viruses. To circumvent this, a mouse model system has been used in which antigen is presented via a differentiated, syngeneic keratinocyte graft expressing human papillomavirus type 16 (HPV-16)
- Molecular characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 strains from Russia.
- J Gen Virol. 2000 May;81 Pt 5:1217-22. Unique Identifier : AIDSLINE GENBANK/AF201853
- Lacoste V; Kadyrova E; Chistiakova I; Gurtsevitch V; Judde JG; Gessain A; Unite d'Oncologie Virale, Departement du SIDA et des; Retrovirus, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris; Cedex 15, France.
- We report the molecular characterization, with subtyping of both K1 and K14.1/K15 genomic regions, of seven new human herpesvirus-8 (HHV-8) strains from Russian patients with classical Kaposi s sarcoma. Phylogenetic studies, based on the complete K1 gene/protein analysis, indicate that six of these strains belong to t
- Properties of a neutralizing antibody that recognizes a conformational form of epitope ERDRD in the gp41 C-terminal tail of human immunodeficiency virus type 1.
- J Gen Virol. 2000 May;81 Pt 5:1251-60. Unique Identifier : AIDSLINE MED/20231935
- Cleveland SM; Jones TD; Dimmock NJ; Department of Biological Sciences, University of Warwick,; Coventry CV4 7AL, UK Axis Genetics plc, Babraham, Cambridge CB2; 4AZ, UK.
- The possibility that epitopes from the C-terminal tail of the gp41 transmembrane protein of human immunodeficiency virus type 1 (HIV-1) are exposed the surface of the virion has long been contentious. Resolution of this has been hampered by the absence of any neutralizing monoclonal antibodies, but we have recently ep
- CD8(+) cell noncytotoxic anti-human immunodeficiency virus response inhibits expression of viral RNA but not reverse transcription or provirus integration.
- J Gen Virol. 2000 May;81 Pt 5:1261-4. Unique Identifier : AIDSLINE MED/20231936
- Mackewicz CE; Patterson BK; Lee SA; Levy JA; Department of Medicine, University of California, San Francisco,; CA 94143, USA.
- CD8(+) T cells from human immunodeficiency virus (HIV)-infected individuals can suppress HIV replication in CD4(+) cells by a noncytotoxic mechanism that inhibits the expression of viral RNA. The present study examined whether other step(s) in the virus replicative cycle could be affected by the CD8(+) cells. Culturin
- Suboptimal splice sites of equine infectious anaemia virus control Rev responsiveness.
- J Gen Virol. 2000 May;81 Pt 5:1265-72. Unique Identifier : AIDSLINE MED/20231937
- Rosin-Arbesfeld R; Yaniv A; Gazit A; Department of Human Microbiology, Sackler School of Medicine, Tel; Aviv University, Tel Aviv 69978, Israel.
- The Rev protein of equine infectious anaemia virus (EIAV) was shown previously to stimulate the expression of a heterologous CAT reporter gene when the 3 half of the EIAV genome was present downstream in cis. However, computer analysis could not reveal the existence of a stable RNA secondary structure that could be a
- A novel sensitive approach for frequency analysis of measles virus-specific memory T-lymphocytes in healthy adults with a childhood history of natural measles.
- J Gen Virol. 2000 May;81 Pt 5:1313-9. Unique Identifier : AIDSLINE MED/20231942
- Nanan R; Rauch A; Kampgen E; Niewiesk S; Kreth HW; Children's Hospital, University of Wurzburg and Department of; Dermatology, Josef-Schneider-Str. 2, D-97080 Wurzburg, Germany.; nanan@mail.uni-wuerzberg.de Wurzburg, Germany.
- Measles virus (MV), a single-stranded negative-sense RNA virus, is an important pathogen causing almost 1 million deaths annually. Acute MV infection induces immunity against disease throughout life. The immunological factors which are responsible for protection against measles are still poorly understood. However, T-
- Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages.
- J Med Virol. 2000 Jun;61(2):171-80. Unique Identifier : AIDSLINE MED/20259893
- Aquino-De Jesus MJ; Anders C; Miller G; Sleasman JW; Goodenow MM; Andiman WA; Department of Pediatrics, Yale University, New Haven, Connecticut; 06520.
- The objective of this study was to identify phenotypic parameters that could distinguish among seemingly homogeneous non-syncytium-inducing (NSI) viruses and that might provide a surrogate marker for clinical progression in pediatric human immunodeficiency virus type 1 (HIV-1) infection. We undertook a pilot analysis
- Prevalence of drug resistant mutants and virological response to combination therapy in patients with primary HIV-1 infection.
- J Med Virol. 2000 Jun;61(2):181-6. Unique Identifier : AIDSLINE MED/20259894
- Tamalet C; Pasquier C; Yahi N; Colson P; Poizot-Martin I; Lepeu G; Gallais H; Massip P; Puel J; Izopet J; Laboratoire de Virologie, Hopital Timone, Marseille, France.; ctamalet@ap-hm.fr
- Baseline genotype resistance analysis was carried out in 48 adults with primary HIV-1 infection between 1995 and 1998 before starting early combination therapy . Seventeen percent (8/48) of the isolates displayed key mutations conferring resistance to reverse transcript
- Problems in the interpretation of HIV-1 viral load assays using commercial reagents.
- J Med Virol. 2000 Jun;61(2):187-94. Unique Identifier : AIDSLINE MED/20259895
- O'Shea S; Chrystie I; Cranston R; Mullen J; Corbett K; Murphy G; Parry JV; De Ruiter A; Banatvala J; Department of Virology, Guy's and St. Thomas' Hospital Trust,; London, United Kingdom. o'shea@gstt.sthames.nhs.uk
- During routine monitoring of human immunodeficiency virus (HIV) viral load, two problems arose. First, a number of patients, the majority being African, were found to have low viral loads by the Chiron branched-chain DNA assay in conjunction with low CD4(+) cell numbers. In order to determine whether this was due to f
- Lack of protection against vertical transmission of HIV-1 by interferons produced during pregnancy in a cohort from East African republic of Malawi.
- J Med Virol. 2000 Jun;61(2):195-200. Unique Identifier : AIDSLINE MED/20259896
- Zachar V; Fazio-Tirrozzo G; Fink T; Roberts DJ; Broadhead RL; Brabin B; Ebbesen P; Department for Virus and Cancer, Danish Cancer Society, Aarhus,; Denmark. vladimir@virus.aau.dk
- Interferons (IFNs) associated with pregnancy were studied for their possible role in inhibition of vertical transmission of the human immunodeficiency virus type 1 (HIV-1). A study group was composed of 43 HIV-1-positive mothers, of whom 15 transmitted the virus to the offspring and 28 did not. The control group inclu
- Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes.
- J Med Virol. 2000 Jun;61(2):201-7. Unique Identifier : AIDSLINE MED/20259897
- Wutzler P; Doerr HW; Farber I; Eichhorn U; Helbig B; Sauerbrei A; Brandstadt A; Rabenau HF; Institute for Antiviral Chemotherapy, Friedrich-Schiller; University of Jena, Jena, Germany. wutzler@zmkh.ef.uni-jena.de
- This study was carried out to determine the prevalence of antibodies to herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) in selected German populations, such as blood donors, hospital patients, and human immunodeficiency virus (HIV)-seropositive individuals. Serum samples collected between 1996 and 1998 were tested
- Multiplex polymerase chain reaction for the evaluation of cytomegalovirus DNA load in organ transplant recipients.
- J Med Virol. 2000 Jun;61(2):251-8. Unique Identifier : AIDSLINE MED/20259904
- Nazzari C; Gaeta A; Lazzarini M; Castelli TD; Mancini C; I Chair of Clinical Microbiology, School of Medicine, La Sapienza; University, Rome, Italy. mancini@axrma.uniroma1.it
- Because of the considerable impact of human cytomegalovirus (HCMV) infection, sensitive, specific, and standardized methods are required for rapid and accurate evaluation of viral load in monitoring transplant recipients. The aim of the present study was to evaluate the usefulness
- Experiences and comfort with culturally diverse groups in undergraduate pre-nursing students.
- J Nurs Educ. 2000 Apr;39(4):161-5. Unique Identifier : AIDSLINE MED/20242854
- Eliason MJ; Raheim S; College of Nursing, University of Iowa, Iowa City 52242, USA.
- A sample of approximately 200 undergraduate students beginning their nursing education responded to questionnaire items concerning experience and levels of comfort working with diverse client groups. Students reported little discomfort with racial/ethnic groups, but reported they would have considerable difficulty wor
- Molecular modelling study of HIV p17gag (MA) protein shell utilising data from electron microscopy and X-ray crystallography.
- J Mol Biol. 2000 May 19;298(5):841-57. Unique Identifier : AIDSLINE MED/20263885
- Forster MJ; Mulloy B; Nermut MV; Informatics Laboratory, National Institute for Standards and; Control, South Mimms, Herfordshire, UK. mforster@nibsc.ac.uk
- The matrix protein p17gag (MA) is a product of proteolytic cleavage of the gag gene encoded polyprotein (pr55gag) and is formed when HIV particles undergo the process of maturation. The MA protein is associated with the inner surface of the viral membrane and determines the overall shape of the virion. Previous studie
- Paediatric HIV infection in a rural South African district hospital.
- J Trop Pediatr. 2000 Apr;46(2):107-10. Unique Identifier : AIDSLINE MED/20282345
- Yeung S; Wilkinson D; Escott S; Gilks CF; Hlabisa Hospital, South Africa.
- The objective of this study was to determine the prevalence, clinical spectrum, and outcome of paediatric HIV infection in 281 consecutive children admitted to hospital in rural South Africa between October 1996 and January 1997. HIV infection was defined as two positive ELISAs in
- Yeast tissue phase of Emmonsia pasteuriana inoculated in golden hamster by intratesticular way.
- Mycoses. 1999;43 Suppl 2:11-8. Unique Identifier : AIDSLINE MED/20287157
- Drouhet E; Huerre M; Institut Pasteur, Unite de Mycologie, Paris, France.
- The scope of our study was to present an experimental model reproducing the dimorphic yeast-like population (as for Histoplasma capsulatum, Blastomyces dermatitidis) similar to that observed in the cutaneous biopsy of an Italian woman who had never traveled abroad, being intravenous drug user and HIV positive for 10 y
- Disseminated Penicillium marneffei infection in an HIV-positive female from Thailand in Germany.
- Mycoses. 1999;43 Suppl 2:25-8. Unique Identifier : AIDSLINE MED/20287159
- Rimek D; Zimmermann T; Hartmann M; Prariyachatigul C; Kappe R; Hygiene-Institut, Heidelberg, Germany.; dagmar_rimek@med.uni-heidelberg.de
- We report the case of a 33 year old Thai female, who was married in Germany for eight years and used to travel to Thailand every year for several weeks. She presented with abdominal and back pain, prolonged fever, generalized lymphadenopathy,
- Cytokine modulation of specific and nonspecific immunity to Candida albicans.
- Mycoses. 1999;43 Suppl 2:45-8. Unique Identifier : AIDSLINE MED/20287163
- Romani L; Department of Experimental Medicine and Biochemical Science,; University of Perugia, Medical School, Italy. lromani@unipg.it
- Recent observations on reciprocal regulation of humoral and cell-mediated immunity to Candida albicans are presented and their significance in the exploration of the host-fungus-relationship is discussed.
- Therapeutic experience with fluconazole in the treatment of fungal infections in diabetic patients.
- Mycoses. 1999;43 Suppl 2:97-100. Unique Identifier : AIDSLINE MED/20287173
- Penk A; Pittrow L; Pfizer GmbH, Medical Department, Karlsruhe, Germany.
- Diabetes mellitus is associated with a higher incidence of certain infections, including fungal infections like rhinocerebral zygomycosis (RCZ) and cutaneous candidosis. As the pathophysiology of increased susceptibility to infection of diabetic patients is very complex, a general therapeutic approach is not existing
- Ethical considerations in the treatment of infertility in women with human immunodeficiency virus infection.
- N Engl J Med. 2000 Jun 8;342(23):1748-50. Unique Identifier : AIDSLINE MED/20285043
- Minkoff H; Santoro N; Maimonides Medical Center, Brooklyn, NY 11219, USA.
- Antiretroviral therapy in patients with dual infection with human immunodeficiency virus types 1 and 2 [letter]
- N Engl J Med. 2000 Jun 8;342(23):1758-60. Unique Identifier : AIDSLINE MED/20285056
- Schutten M; van der Ende ME; Osterhaus AD
- Congo war increases threat to bonobo research [news]
- Nature. 2000 May 18;405(6784):262. Unique Identifier : AIDSLINE MED/20289771
- Saegusa A
- NIH takes charge of chimps infected in experiments [news]
- Nature. 2000 May 18;405(6784):262. Unique Identifier : AIDSLINE MED/20289772
- Smaglik P
- But South Africa voices reservations [news]
- Nature. 2000 May 18;405(6784):263. Unique Identifier : AIDSLINE MED/20289774
- Cherry M
- Cheaper AIDS drugs due for Third World..[news]
- Nature. 2000 May 18;405(6784):263. Unique Identifier : AIDSLINE MED/20289773
- Brown P
- Reservoirs dog AIDS therapy [news]
- Nature. 2000 May 18;405(6784):270-2. Unique Identifier : AIDSLINE MED/20289782
- Smaglik P
- AIDS dissidents aren't victims--but the people their ideas kill will be [letter]
- Nature. 2000 May 18;405(6784):273. Unique Identifier : AIDSLINE MED/20289783
- Rybicki E; Williamson AL; Morris L
- [Dendritic cells as carriers of human immunodeficiency virus (HIV)]
- Ned Tijdschr Geneeskd. 2000 Apr 22;144(17):786-8. Unique Identifier : AIDSLINE MED/20260340
- Borleffs JC; Boucher CA; Afd. Interne Geneeskunde, onderafd. Infectieziekten & Aids,; Universitair Medisch Centrum Utrecht. j.c.c.borleffs@digd.azu.nl
- In two papers in Cell researchers of the University Medical Center St. Radboud in Nijmegen (in collaboration with Utrecht and US researchers) have published the results of studies dealing with dendritic cells and their role in the pathogenesis of HIV-1 infection. First, they identified a dendritic cell receptor, DC-SI
- Acute pharyngitis with lifelong implications.
- Nurse Pract. 2000 Apr;25(4):119-22. Unique Identifier : AIDSLINE MED/20251396
- Leiner S; Mission Neighborhood Health Center, San Francisco, Calif., USA.
- A 32-year-old man presents with exudative pharyngitis and constitutional symptoms. This article discusses diagnostic pitfalls and explores the intricacies of therapeutic options.
- Fever and a rash in a 61 year old man.
- Postgrad Med J. 2000 Apr;76(894):237, 243-4. Unique Identifier : AIDSLINE MED/20193954
- Federman DG; Kirsner RS; Department of Internal Medicine, Yale University School of; Medicine, New Haven, Connecticut, USA.
- Impact of HIV infection on tuberculosis.
- Postgrad Med J. 2000 May;76(895):259-68. Unique Identifier : AIDSLINE MED/20237867
- Zumla A; Malon P; Henderson J; Grange JM; Centre for Infectious Diseases, University College London, Royal; Free and University College Medical School, Windeyer Institute of; Medical Sciences, Room G41, 46 Cleveland Street, London W1P 6DB,; UK. a.zumla@ucl.ac.uk
- Tuberculosis is increasing in prevalence in many countries and is now the leading infectious cause of death world wide, being responsible for three million deaths annually. Infection with HIV, likewise increasing in prevalence, has emerged as the most important predisposing factor for developing overt tuberculosis in
- The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability.
- Proc Natl Acad Sci U S A. 2000 May 9;97(10):5107-12. Unique Identifier : AIDSLINE PDB/1DUQ
- Hung LW; Holbrook EL; Holbrook SR; Macromolecular Crystallography Facility and Structural Biology; Department, Melvin Calvin Building, Physical Biosciences; Division, Lawrence Berkeley National Laboratory, University of; California, Berkeley, CA 94720, USA.
- The crystal and molecular structure of an RNA duplex corresponding to the high affinity Rev protein binding element (RBE) has been determined at 2.1-A resolution. Four unique duplexes are present in the crystal, comprising two structural variants. In each duplex, the RNA double helix consists of an annealed 12-mer and
- Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.
- Proc Natl Acad Sci U S A. 2000 May 9;97(10):5393-8. Unique Identifier : AIDSLINE MED/20266376
- Fleury S; Rizzardi GP; Chapuis A; Tambussi G; Knabenhans C; Simeoni E; Meuwly JY; Corpataux JM; Lazzarin A; Miedema F; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Department of Medicine,; Divisions of Infection Diseases and of Immunology, Centre; Hospitalier Universitaire Vaudois, University of Lausanne, 1011; Lausanne, Switzerland.
- The long-term kinetics of T cell production following highly active antiretroviral therapy (HAART) were investigated in blood and lymph node in a group of HIV-infected subjects at early stage of established infection and prospectively studied for 72 wk. Before HAART, CD4 and CD8 T cell turnover was increased. However,
- An autologous oral DNA vaccine protects against murine melanoma.
- Proc Natl Acad Sci U S A. 2000 May 9;97(10):5492-7. Unique Identifier : AIDSLINE MED/20266393
- Xiang R; Lode HN; Chao TH; Ruehlmann JM; Dolman CS; Rodriguez F; Whitton JL; Overwijk WW; Restifo NP; Reisfeld RA; The Scripps Research Institute, Department of Immunology, 10550; North Torrey Pines Road, La Jolla, CA 92037, USA.
- We demonstrated that peripheral T cell tolerance toward murine melanoma self-antigens gp100 and TRP-2 can be broken by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to minigenes encoding peptide epitopes gp100(25-33) and TRP-2(181-188). These epitopes contain dominant anchor residues for MH
- A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.
- Proc Natl Acad Sci U S A. 2000 May 9;97(10):5639-44. Unique Identifier : AIDSLINE MED/20266418
- Dragic T; Trkola A; Thompson DA; Cormier EG; Kajumo FA; Maxwell E; Lin SW; Ying W; Smith SO; Sakmar TP; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, NY 10016, USA. tdragic@aecom.yu.edu
- HIV-1 entry into CD4(+) cells requires the sequential interactions of the viral envelope glycoproteins with CD4 and a coreceptor such as the chemokine receptors CCR5 and CXCR4. A plausible approach to blocking this process is to use small molecule antagonists of coreceptor function. One such inhibitor has been describ
- Schizophrenic psychosis: a contraindication for treatment of hepatitis C with interferon alpha?
- Pharmacopsychiatry. 2000 Mar;33(2):72-4. Unique Identifier : AIDSLINE MED/20222460
- Dobmeier M; Frick E; Frank S; Franke C; Wolfersdorf M; Clinic for Psychiatry and Psychotherapy of the University of; Regensburg, Germany. matthias.dobmeier@bzk.uni-regensburg.de
- Depressive or psychotic symptoms are a well known side-effect of interferon alpha (INF-alpha). Therefore, the questions arises whether a chronic psychosis should be considered a contraindication for the treatment of active hepatitis C with INF-alpha. We report on a 38-year-old woman with a chronic schizophrenic psycho
- [Physiopathology and treatment of acquired immunodeficiency syndrome]
- Rev Invest Clin. 2000 Jan-Feb;52(1):60-71. Unique Identifier : AIDSLINE MED/20278753
- Soto Ramirez LE; Departamento de Infectologia, Instituto Nacional de Nutricion; Salvador Zubiran. lsoto@quetzal.innsz.mx
- The last pandemia of the century, that of the Acquired Immunodeficiency Syndrome (AIDS) caused by the Human Immunodeficiency Virus (HIV), continues to advance with gigantic steps at about 18,000 new infections per day worldwide. In the last four years, breakthroughs have been achieved and new medications have been int
- [Pulmonary hypertension and HIV infection: report of a case]
- Unique Identifier : AIDSLINE MED/20295466
- Karmelic C; Castro P; Perez C
- Pulmonary hypertension associated to HIV infection has been reported in the literature with increased frequency. Apparently,
- Functions of oral candidiasis episodes that are highly prognostic for AIDS.
- Stat Med. 2000 Apr 15;19(7):989-1004. Unique Identifier : AIDSLINE MED/20215101
- Hilton JF; Department of Epidemiology and Biostatistics, University of; California, San Francisco, California 94143-0560, USA.; joan@biostat.ucsf.edu
- Although oral candidiasis lesions are widely recognized as markers for AIDS, the relative prognostic significance of functions of these episodes has not been examined. We compare the associations with time to AIDS of one fixed and six time-dependent metrics of oral candidiasis lesions, including proximity of a lesion
- The diagnostic value of electron microscopy in human immunodeficiency virus-positive patients with gastrointestinal disease.
- Scand J Gastroenterol. 2000 Mar;35(3):329-32. Unique Identifier : AIDSLINE MED/20227397
- Olofinlade O; Adeonigbagbe O; Karowe M; Robilotti J; Gualtieri N; Cacciarelli A; Berlin I; Guerrieri C; Dept. of Gastroenterology and Pathology, St. Vincent's Hospital,; New York, New York 10011, USA.
- BACKGROUND: Our aim was to determine the diagnostic value of electron microscopy in evaluating the etiology of gastrointestinal disease in patients infected with the human immunodeficiency virus (HIV). METHODS: A retrospective review of electron microscopic and light microscopic results of all HIV-positive patients wi
- Determining the 3D structure of HIV-1 protease [letter]
- Science. 2000 Jun 2;288(5471):1590. Unique Identifier : AIDSLINE MED/20313570
- Kent S; Marshall GR; Wlodawer A
- The laboratory diagnosis of HIV infection.
- S Afr Med J. 2000 Feb;90(2):105-9. Unique Identifier : AIDSLINE MED/20210052
- Martin D; Sim J
- New notifiability policy [news]
- S Afr Med J. 2000 Feb;90(2):95-6. Unique Identifier : AIDSLINE MED/20210049
- UN's first health issue [news]
- S Afr Med J. 2000 Feb;90(2):96. Unique Identifier : AIDSLINE MED/20210050
- Howse J
- Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression.
- Transplantation. 2000 Apr 27;69(8):1690-4. Unique Identifier : AIDSLINE MED/20294371
- Ke B; Coito AJ; Kato H; Zhai Y; Wang T; Sawitzki B; Seu P; Busuttil RW; Kupiec-Weglinski JW; The Dumont-UCLA Transplant Center, Department of Surgery, UCLA; School of Medicine, Los Angeles, California 90095, USA.
- BACKGROUND: Fas ligand (FasL) induces apoptosis of cells bearing Fas receptor, and may play a role in the acquisition of immune privilege. We have previously shown that adenovirus (Ad)-mediated FasL gene transfer significantly prolongs survival in a strongly major histocompatibility complex-incompatible rat kidney all
- Additional interferon alpha for lamivudine resistant hepatitis B infection after liver transplantation: a preliminary report.
- Transplantation. 2000 Apr 27;69(8):1739-42. Unique Identifier : AIDSLINE MED/20294383
- Seehofer D; Rayes N; Berg T; Neuhaus R; Hopf U; Muller AR; Bechstein WO; Neuhaus P; Department of Visceral and Transplant Surgery, Humboldt; University of Berlin, Germany.
- Resistance formation is a major problem in antiviral treatment of hepatitis B recurrence after liver transplantation. One possible therapeutic approach is an antiviral combination therapy with synergistic drugs. Four patients who were transplanted for chronic hepatitis
- Independent introduction of transmissible F/D recombinant HIV-1 from Africa into Belgium and The Netherlands.
- Virology. 2000 May 10;270(2):267-77. Unique Identifier : AIDSLINE MED/20255526
- Op de Coul E; van der Schoot A; Goudsmit J; van den Burg R; Janssens W; Heyndrickx L; van der Groen G; Cornelissen M; Division of Public Health and Environment, Municipal Health; Service, Nieuwe Achtergracht 100, Amsterdam, 1018 WT, the; Netherlands. eodcoul@gggd.amsterdam.nl
- Most HIV-1 subtype F viruses described so far have been isolated from individuals originating in South America, Romania , or Central Africa. Previous studies have shown that subtype F viruses from these three areas can be distinguished by phylogenetic tree analysis of various parts
- HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity.
- Virology. 2000 May 10;270(2):291-8. Unique Identifier : AIDSLINE MED/20255529
- Suzuki T; Uchida-Toita M; Andoh T; Yoshida M; Department of Cellular and Molecular Biology, Institute of; Medical Science, Tokyo, Japan.
- HTLV-1 Tax oncoprotein exerts pleiotropic effects on cellular regulatory systems, such as transcription and the cell cycle, through the interaction with various cellular factors. During our search for additional cellular targets of Tax using a yeast two-hybrid screening system, we isolated a cDNA encoding human DNA to
- Multidrug resistance genotypes (insertions in the beta3-beta4 finger subdomain and MDR mutations) of HIV-1 reverse transcriptase from extensively treated patients: incidence and association with other resistance mutations.
- Virology. 2000 May 10;270(2):310-6. Unique Identifier : AIDSLINE MED/20255531
- Tamalet C; Yahi N; Tourres C; Colson P; Quinson AM; Poizot-Martin I; Dhiver C; Fantini J; Laboratoire de Virologie, CISIH-Marseille, France.
- Multiple nucleoside resistance involves specific mutational patterns of the HIV-1 pol gene that are independent of the classic mutations conferring resistance to individual dideoxynucleosides. These include a cluster of five mutations in the reverse-transcriptase (RT) coding region (A62V, V75I, F77L, F116Y, and Q151M)
- Characterization of HIV-1-specific cytotoxic T lymphocytes expressing the mucosal lymphocyte integrin CD103 in rectal and duodenal lymphoid tissue of HIV-1-infected subjects.
- Virology. 2000 May 10;270(2):317-27. Unique Identifier : AIDSLINE MED/20255532
- Shacklett BL; Beadle TJ; Pacheco PA; Grendell JH; Haslett PA; King AS; Ogg GS; Basuk PM; Nixon DF; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, NY 10016, USA. bshackle#adarc.org
- Acute HIV-1 infection depletes CD4(+) T cells in gut-associated lymphoid tissue (GALT). The failure of containment of local viral replication, and consequent CD4(+) T cell depletion, might be due to delayed mobilization of effector CD8(+) T cells or absence of functioning HIV-1-specific CD8(+) T cell effectors within
- Sequences flanking the cAMP responsive core of the HTLV-I tax response elements influence CREB protease sensitivity.
- Virology. 2000 May 10;270(2):328-36. Unique Identifier : AIDSLINE MED/20255533
- Connor LM; Marriott SJ; Department of Molecular Virology and Microbiology, Baylor College; of Medicine, Houston, Texas 77030, USA.
- The human T cell leukemia virus type I (HTLV-I) Tax protein activates transcription from the viral long terminal repeat and select cellular promoters by interacting with cellular DNA-binding proteins. The HTLV-I promoter contains three copies of a Tax-responsive element (TRE-1), each of which possesses a core cAMP res
- HIV-1 replication is inhibited by a pseudo-substrate peptide that blocks Tat transactivation.
- Virology. 2000 May 10;270(2):337-44. Unique Identifier : AIDSLINE MED/20255534
- Okamoto H; Cujec TP; Peterlin BM; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi,; 467-8601, Japan.
- The activation of the HIV-1 long terminal repeat (LTR) by the viral transcriptional transactivator Tat is an essential step in the viral replication cycle. To increase the processivity of RNA polymerase II, Tat interacts with the positive transcription elongation factor b (P-TEFb) and cyclin-dependent kinase (CDK)-act
- Epstein-barr virus latent membrane protein (LMP1) induces specific NFkappaB complexes in human T-lymphoid cells.
- Virus Res. 2000 Mar;67(1):17-30. Unique Identifier : AIDSLINE MED/20238017
- Chien ML; Hammarskjold ML; Department of Microbiology, State University of New York at; Buffalo, Buffalo, NY 14214, USA.
- The Epstein-Barr virus (EBV) latent membrane protein (LMP1) is believed to play a crucial role in oncogenesis mediated by this virus. We and others previously showed that LMP1 can induce NFkappaB activity in several non-lymphoid cells and B-lymphoid cell lines. Here we show that LMP1 is also able to efficiently induce
- CD4(+) T-cell responses to bovine viral diarrhoea virus in cattle.
- Virus Res. 2000 Mar;67(1):67-80. Unique Identifier : AIDSLINE MED/20238022
- Collen T; Morrison WI; Division of Immunopathology, Institute for Animal Health,; Compton, UK. trevor.collen@bbsrc.ac.uk
- Friesian calves were infected with one of three isolates of bovine viral diarrhoea virus (BVDV) and used to establish parameters for an in vitro model of BVDV-reactive T-cell responses in cattle. The study assessed virus clearance, seroconversion, maturation of lymphoproliferative responses (both during and following
- Molecular characterization of HERV-H variants associated with multiple sclerosis.
- Acta Neurol Scand. 2000 Apr;101(4):229-38. Unique Identifier : AIDSLINE MED/20231287
- Christensen T; Dissing Sorensen P; Riemann H; Hansen HJ; Munch M; Haahr S; Moller-Larsen A; Department of Medical Microbiology and Immunology, University of; Aarhus, Denmark.
- Our objective was to characterize retroviral sequences by RT-PCR with gag and env primers on RNA from RT-positive retroviral particles produced by multiple sclerosis (MS) derived B-lymphoblastoid cell lines. Sequence variants with high homology to the potentially functional subgroup RGH of the human endogenous retrovi
- Oxacillin-resistant Staphylococcus aureus endophthalmitis after ganciclovir intraocular implant.
- Am J Ophthalmol. 2000 Apr;129(4):554-5. Unique Identifier : AIDSLINE MED/20229462
- Williamson JC; Virata SR; Raasch RH; Kylstra JA; Department of Pharmacy, University of North Carolina Hospitals; and Clinics, Chapel Hill, North Carolina, USA.; johnwill@wfubmc.edu
- PURPOSE: To describe a patient who developed oxacillin-resistant Staphylococcus aureus endophthalmitis after insertion of a ganciclovir intraocular implant. METHOD: Case report. RESULTS: A 42-year-old man with acquired immunodeficiency syndrome (AIDS) and a history of cytomegalovirus
- Cholangiocarcinoma and AIDS-related sclerosing cholangitis [letter]
- Ann Intern Med. 2000 Jun 20;132(12):1006-7. Unique Identifier : AIDSLINE MED/20300530
- Hocqueloux L; Gervais A
- Epidemiologic relation between HIV and invasive pneumococcal disease in San Francisco County, California [letter]
- Ann Intern Med. 2000 Jun 20;132(12):1009. Unique Identifier : AIDSLINE MED/20300537
- Dworkin MS; Hanson DL
- Epidemiologic relation between HIV and invasive pneumococcal disease in San Francisco County, California [letter]
- Ann Intern Med. 2000 Jun 20;132(12):1009. Unique Identifier : AIDSLINE MED/20300536
- Grau I; Linares J; Pallares R
- Cocaine-induced acute cytologic hepatitis in HIV-infected patients with nonactive viral hepatitis [letter]
- Ann Intern Med. 2000 Jun 20;132(12):1010-1. Unique Identifier : AIDSLINE MED/20300539
- Peyriere H; Mauboussin JM
- Parvovirus B19-related anemia in an HIV-infected patient: rapid control after production of neutralizing antibodies during highly active antiretroviral therapy [letter]
- Ann Intern Med. 2000 Jun 20;132(12):1011. Unique Identifier : AIDSLINE MED/20300540
- Arribas JR; Pena JM; Echevarria JE
- Effect of hepatitis G virus infection on progression of HIV infection in patients with hemophilia. Multicenter Hemophilia Cohort Study.
- Ann Intern Med. 2000 Jun 20;132(12):959-63. Unique Identifier : AIDSLINE MED/20300513
- Yeo AE; Matsumoto A; Hisada M; Shih JW; Alter HJ; Goedert JJ; National Institutes of Health, Warren Grant Magnuson Clinical; Center, Department of Transfusion Medicine, Bethesda, Maryland; 20892, USA.
- BACKGROUND: Infection with hepatitis G virus (HGV), also known as GB virus C, is prevalent but is not known to be associated with any chronic disease. Infection with HGV may affect the risk for AIDS in HIV-infected persons. OBJECTIVE: To compare AIDS-free survival in patients with and those without HGV infection durin
- Salmonella meningitis in children in Blantyre, Malawi, 1996-1999.
- Ann Trop Paediatr. 2000 Mar;20(1):41-4. Unique Identifier : AIDSLINE MED/20284226
- Molyneux EM; Walsh AL; Malenga G; Rogerson S; Molyneux ME; Department of Paediatrics, College of Medicine, Queen Elizabeth; Central Hospital, Blantyre, Malawi. emolyneux@malawi.net
- Sixty-one episodes of Salmonella meningitis were identified during a 3-year period from February 1996 to January 1999 inclusive. These accounted for 6.8% of all the acute bacterial meningitis cases seen during this time. In contrast, only two children were admitted with Salmonella meningitis in 1982. The increase may
- The impact of the human immunodeficiency virus type 1 on the management of severe malnutrition in Malawi.
- Ann Trop Paediatr. 2000 Mar;20(1):50-6. Unique Identifier : AIDSLINE MED/20284228
- Kessler L; Daley H; Malenga G; Graham S; Department of Paediatrics, College of Medicine, Blantyre, Malawi.
- A study was undertaken in a central nutritional rehabilitation unit in southern Malawi to assess the impact of HIV infection on clinical presentation and case fatality rate. HIV seroprevalence in 250 severely malnourished children over 1 year of age was 34.4% and overall mortality
- Older adults and HIV.
- AORN J. 2000 Apr;71(4):873-6. Unique Identifier : AIDSLINE MED/20266504
- Moore LW; Amburgey LB; Department of Nursing, Xavier University, Cincinnati, USA.
- As the number of older Americans grows, perioperative nurses increasingly will be called on to provide services to older adults infected with HIV. To provide quality patient care, perioperative nurses must understand the facts about HIV and aging individuals. Finally, perioperative nurses must realize the best defense
- Human immunodeficiency virus-related primary cutaneous aspergillosis.
- Australas J Dermatol. 2000 May;41(2):112-6. Unique Identifier : AIDSLINE MED/20272587
- Stanford D; Boyle M; Gillespie R; Department of Dermatology, Royal Newcastle Hospital, New South; Wales, Australia. duncan_stanford@bigpond.com
- A 31-year-old Caucasian man with AIDS developed a crusted violaceous plaque under adhesive tape near a central venous catheter insertion site. Histological examination demonstrated a ruptured hair follicle containing collections of fungal hyphae typical of Aspergillus spp. A culture of the biopsy material grew Aspergi
- Direct immunization of malaria DNA vaccine into the liver by gene gun protects against lethal challenge of Plasmodium berghei sporozoite.
- Biochem Biophys Res Commun. 2000 Apr 29;271(1):107-15. Unique Identifier : AIDSLINE MED/20241828
- Yoshida S; Kashiwamura SI; Hosoya Y; Luo E; Matsuoka H; Ishii A; Fujimura A; Kobayashi E; Department of Medical Zoology, Center for Molecular Medicine,; Jichi Medical School, 3311-1 Yakushiji, Minamikawachimachi,; Tochigi, Japan. shigeto@jichi.ac.jp
- The liver is the first target organ for malaria parasites immediately after the bite of an infected mosquito. We studied local immunization of malaria DNA vaccines at the site of the liver using a gene gun as a useful tool for in vivo transfection of foreign genes. A malaria DNA vaccine consisting of the Plasmodium be
- [A comparative study of indinavir versus ritonavir for assessing the development of opportunistic diseases in adult AIDS patients]
- Bol Asoc Med P R. 1999 Jul-Dec;91(7-12):85-90. Unique Identifier : AIDSLINE MED/20301256
- Disdier OM; Perez CM; Suarez E; Departamento de Bioestadistica y Epidemiologia, Escuela; Graduada de Salud Publica, Recinto de Ciencias Medicas,; Universidad de Puerto Rico.
- This observational study compared the probability of developing the first opportunistic infection among AIDS adult patients attending the Programa SIDA de San Juan who received either indinavir plus zidovudine and lamivudine (n = 45) or
- Synthesis and antiviral properties of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives as novel Acyclovir analogues.
- Farmaco. 2000 Feb;55(2):104-8. Unique Identifier : AIDSLINE MED/20244237
- Macchia M; Antonelli G; Calvani F; Di Bussolo V; Minutolo F; Orlandini E; Tesoro R; Turriziani O; Dipartimento di Scienze Farmaceutiche, Universita di Pisa,; Italy. mmacchia@farm.unipi.it
- This paper reports the synthesis and the antiviral properties of a series of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives, which can be viewed as analogues of the antiherpes drug Acyclovir (ACV) from which they differ in the replacement of its hydroxy group with vario
- Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles.
- Farmaco. 2000 Feb;55(2):119-24. Unique Identifier : AIDSLINE MED/20244239
- Mazzei M; Dondero R; Ledda B; Demontis F; Vargiu L; Department of Pharmaceutical Sciences, University of Genova,; Italy. mazzei@ermes.cba.unige.it
- Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles possessing a compact structure were active against HRV-2 and, consequently, presented a type B activity. In this paper, 3-(diethylamino)-5-phenylisoxazoles, which are structurally more elongated and related to Disoxaril, were synthesized in view to a
- Polyherbal formulations with wide spectrum antimicrobial activity against reproductive tract infections and sexually transmitted pathogens.
- Am J Reprod Immunol. 2000 Mar;43(3):144-51. Unique Identifier : AIDSLINE MED/20197637
- Talwar GP; Raghuvanshi P; Mishra R; Banerjee U; Rattan A; Whaley KJ; Zeitlin L; Achilles SL; Barre-Sinoussi F; David A; Doncel GF; International Center for Genetic Engineering and Biotechnology,; Aruna Asaf Ali Marg, New Delhi, India.
- PROBLEM: Recent reports indicate high incidence of genital infections, most of which are sexually transmitted. Although specific drugs and antibiotics are available for some, a safe spermicidal formulation with wide spectrum antimicrobial action would be a desirable addition to the presently available spermicides. MET
- Sexual behavior changes and protease inhibitor therapy. SEROCO Study Group.
- AIDS. 2000 Mar 10;14(4):F33-9. Unique Identifier : AIDSLINE MED/20231299
- Miller M; Meyer L; Boufassa F; Persoz A; Sarr A; Robain M; Spira A; National Development and Research Institutes, Inc., Center for; Drug Use and HIV Research, New York, NY 10048, USA.; maureen.miller@ndri.org
- OBJECTIVE: To examine changes in sexual activity and unprotected sexual intercourse among HIV-infected patients before and after the initiation of protease inhibitor therapy. DESIGN: An analysis of data from the SEROCO Study, a French prospective cohort. METHODS: All 191 patients who initiated protease inhibitor thera
- Lack of mother-to-child HIV-1 transmission is associated with elevated serum levels of 90 K immune modulatory protein.
- AIDS. 2000 Mar 10;14(4):F41-5. Unique Identifier : AIDSLINE MED/20231300
- Pelliccia P; Galli L; de Martino M; Chiarelli F; Verrotti A; Sabatino G; Fornarini B; Iacobelli S; Natoli C; Department of Medicine, University of Chieti, Italy.
- BACKGROUND: 90 K is a secreted human serum glycoprotein with immune modulatory activity. METHODS: Serum 90 K levels were determined by an enzyme-linked immunosorbent assay in 19 HIV-1-infected mothers at the time of delivery, in their new-borns (11 HIV-1 infected and eight uninfected), in 26 HIV-1-uninfected mothers a
- Sexual risk behaviors among heterosexual HIV serodiscordant couples in the era of post-exposure prevention and viral suppressive therapy.
- AIDS. 2000 Mar 10;14(4):F47-54. Unique Identifier : AIDSLINE MED/20231301
- van der Straten A; Gomez CA; Saul J; Quan J; Padian N; Center for AIDS Prevention Studies, Department of Obstetrics,; Gynecology and Reproductive Sciences, University of California,; San Francisco, 94105, USA. avdstraten@psg.ucsf.edu
- OBJECTIVES: To describe awareness and use of antiretroviral treatments, viral load monitoring, and post-exposure prevention; to assess changing concerns about HIV transmission; and to examine the effect of these advances on sexual behavior in HIV-serodiscordant heterosexual couples. METHODS: Cross-sectional analysis o
- Progressive specific immune attrition after primary, secondary and tertiary immunizations with bacteriophage phi X174 in asymptomatic HIV-1 infected patients.
- AIDS. 2000 Mar 10;14(4):F55-62. Unique Identifier : AIDSLINE MED/20231302
- Rubinstein A; Mizrachi Y; Bernstein L; Shliozberg J; Golodner M; Liu GQ; Ochs HD; Department of Pediatrics, Albert Einstein College of Medicine,; Bronx, NY 10461, USA.
- BACKGROUND: Antibody responses to immunization are often compromised in patients infected by HIV-1, and the use of childhood immunization in affected children is controversial. We investigated whether multiple immunizations with a T cell-dependent neoantigen, bacteriophage phiX174, induce selective immune attrition an
- Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy.
- AIDS. 2000 Mar 10;14(4):F63-7. Unique Identifier : AIDSLINE MED/20231303
- Tebas P; Powderly WG; Claxton S; Marin D; Tantisiriwat W; Teitelbaum SL; Yarasheski KE; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63108, USA. tebas@im.wustl.edu
- BACKGROUND: The use of highly active antiretroviral therapy (HAART) has been associated with multiple metabolic complications whose pathogenesis is poorly understood at the present time. METHODS: We performed a cross-sectional analysis of whole-body, lumbar spine (L1-L4) and proximal femur bone mineral density in 112
- Plasma RNA viral load predicts the rate of CD4 T cell decline and death in HIV-2-infected patients in West Africa.
- AIDS. 2000 Mar 10;14(4):339-44. Unique Identifier : AIDSLINE MED/20231304
- Ariyoshi K; Jaffar S; Alabi AS; Berry N; van der Loeff MS; Sabally S; N'Gom PT; Corrah T; Tedder R; Whittle H; Medical Research Council Laboratories, The Gambia, West Africa.
- OBJECTIVE: To examine whether the levels of plasma RNA and DNA provirus predict the rate of CD4 cell decline and patient death. DESIGN: Retrospective analysis of HIV-2 cohort subjects. METHODS: Fifty-two subjects were recruited between January 1991 and December 1992. HIV-2 RNA levels in plasma and DNA levels in periph
- Deregulation of the CD95/CD95L system in lymphocytes from patients with primary acute HIV infection.
- AIDS. 2000 Mar 10;14(4):345-55. Unique Identifier : AIDSLINE MED/20231305
- Cossarizza A; Stent G; Mussini C; Paganelli R; Borghi V; Nuzzo C; Pinti M; Pedrazzi J; Benatti F; Esposito R; Rosok B; Nagata S; Vella S; Franceschi C; De Rienzo B; Department of Biomedical Sciences, University of Modena School of; Medicine, Italy.
- OBJECTIVE: To analyze the role of CD95/CD95 ligand (CD95L) expression and functionality in peripheral blood lymphocytes (PBL) during primary, acute HIV syndrome (AHS) and in the subsequent period. PATIENTS: Twelve patients were studied during the acute phase of the viral infection and most were followed for some month
- Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population.
- AIDS. 2000 Mar 10;14(4):357-66. Unique Identifier : AIDSLINE MED/20231306
- Bangsberg DR; Hecht FM; Charlebois ED; Zolopa AR; Holodniy M; Sheiner L; Bamberger JD; Chesney MA; Moss A; Epidemiology and Prevention Interventions Center, Division of; Infectious Diseases, San Francisco General Hospital, University; of California San Francisco, 94110, USA. db@epi-center.ucsf.edu
- OBJECTIVE: To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless and marginally housed people on protease inhibitor (PI) therapy. DESIGN AND SETTING: A cross-sectional analysis of subjects in an observational prospective cohort systematically sampled fr
- AVANTI 2. Randomized, double-blind trial to evaluate the efficacy and safety of zidovudine plus lamivudine versus zidovudine plus lamivudine plus indinavir in HIV-infected antiretroviral-naive patients.
- AIDS. 2000 Mar 10;14(4):367-74. Unique Identifier : AIDSLINE MED/20231307
- OBJECTIVES: To investigate the effect of combination antiretroviral therapy on plasma HIV-1 RNA as measured by HIV RNA PCR and to assess their safety and tolerability. DESIGN: A randomized, multicentre, double-blind, placebo-controlled trial. SETTING: Multicentre study in eight European countries,
- Comparison of clinical features, CD4 and CD8 responses among patients with acute HIV-1 infection from Geneva, Seattle and Sydney.
- AIDS. 2000 Mar 10;14(4):375-81. Unique Identifier : AIDSLINE MED/20231308
- Vanhems P; Hughes J; Collier AC; Vizzard J; Perrin L; Cooper DA; Hirschel B; Corey L; Laboratoire d'Epidemiologie et de Sante Publique, INSERM U-271,; Universite Claude Bernard, Lyon, France.
- OBJECTIVE: To compare the clinical features and T-cell subsets among 160 patients with acute HIV-1 infection not treated with antiretroviral agents from three different locations (Geneva, Seattle and Sydney). DESIGN: Patients with documented acute HIV-1 infection were enrolled in four prospective studies: one randomiz
- Discontinuation of secondary prophylaxis for opportunistic infections in HIV-infected patients receiving highly active antiretroviral therapy.
- AIDS. 2000 Mar 10;14(4):383-6. Unique Identifier : AIDSLINE MED/20231309
- Soriano V; Dona C; Rodriguez-Rosado R; Barreiro P; Gonzalez-Lahoz J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- BACKGROUND: Immune reconstitution following the introduction of highly active antiretroviral therapies (HAART) has lead to a remarkable reduction in the incidence of opportunistic infections (OI) in subjects with advanced HIV disease. Moreover, discontinuation of primary prophylaxis for some OI can be attempted withou
- Phase III study of granulocyte-macrophage colony-stimulating factor in advanced HIV disease: effect on infections, CD4 cell counts and HIV suppression. Leukine/HIV Study Group.
- AIDS. 2000 Mar 10;14(4):387-95. Unique Identifier : AIDSLINE MED/20231310
- Angel JB; High K; Rhame F; Brand D; Whitmore JB; Agosti JM; Gilbert MJ; Deresinski S; University of Ottawa, Ontario, Canada.
- OBJECTIVE: To evaluate the effect of adjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF) (sargramostim, yeast-derived recombinant human GM-CSF) on incidence and time to opportunistic infection or death, plasma HIV-RNA, and CD4 cell count in patients with advanced HIV disease. METHODS: This Phase III ran
- Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppression.
- AIDS. 2000 Mar 10;14(4):397-403. Unique Identifier : AIDSLINE MED/20231311
- Ruiz L; Martinez-Picado J; Romeu J; Paredes R; Zayat MK; Marfil S; Negredo E; Sirera G; Tural C; Clotet B; Retrovirology Laboratory irsiCaixa Foundation, University; Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.
- OBJECTIVE: To investigate the virological and immunological impact of a structured treatment interruption (STI) in a cohort of HIV-1 chronically infected patients with a further long-lasting effective virus suppression. METHODS: Twelve HIV-1 chronically infected adults who had maintained viral suppression (
- The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine. Prometheus Study Group.
- AIDS. 2000 Mar 10;14(4):405-13. Unique Identifier : AIDSLINE MED/20231312
- Gisolf EH; Jurriaans S; Pelgrom J; van Wanzeele F; van der Ende ME; Brinkman K; Borst MJ; de Wolf F; Japour AJ; Danner SA; National AIDS Therapy Evaluation Center, Department of Internal; Medicine, Academic Medical Center, Amsterdam, The Netherlands.
- OBJECTIVE: To evaluate the effect of treatment with ritonavir (RTV)/saquinavir (SQV)/6 stavudine (D4T) or RTV/SQV alone, with treatment intensification if needed, in protease inhibito
- Effect of highly active antiretroviral therapy on cervicovaginal HIV-1 RNA.
- AIDS. 2000 Mar 10;14(4):415-21. Unique Identifier : AIDSLINE MED/20231313
- Cu-Uvin S; Caliendo AM; Reinert S; Chang A; Juliano-Remollino C; Flanigan TP; Mayer KH; Carpenter CC; Brown University, Providence, RI, USA. scu-uvin@lifespan.org
- OBJECTIVES: To determine the frequency of cervicovaginal lavage and plasma HIV-1 RNA levels that are below detectable levels (
- Syringe exchange not associated with social network formation: results from Baltimore.
- AIDS. 2000 Mar 10;14(4):423-6. Unique Identifier : AIDSLINE MED/20231314
- Junge B; Valente T; Latkin C; Riley E; Vlahov D; Department of Epidemiology, The Johns Hopkins University School; of Hygiene and Public Health, Baltimore, Maryland 21205, USA.
- OBJECTIVE: To examine possible formation of new social contacts at the Baltimore Syringe Exchange Program (SEP). DESIGN: Systematic sub-sample of new SEP participants recruited into evaluation cohort for biannual interviews. This analysis used 6-month interview data. METHODS: Participants were interviewed for behavior
- Seven-year trends in HIV-1 infection rates, and changes in sexual behaviour, among adults in rural Uganda.
- AIDS. 2000 Mar 10;14(4):427-34. Unique Identifier : AIDSLINE MED/20231315
- Kamali A; Carpenter LM; Whitworth JA; Pool R; Ruberantwari A; Ojwiya A; Medical Research Council Programme on AIDS in Uganda, Uganda; Virus Research Institute, Entebbe.
- OBJECTIVE: To assess trends in HIV-1 infection rates and changes in sexual behaviour over 7 years in rural Uganda . METHODS: An adult cohort followed through eight medical-serological annual surveys since 1989-1990. All consenting participants gave a blood sample and were interviewe
- Maternal HIV-1 and HIV-2 infection and child survival in The Gambia.
- AIDS. 2000 Mar 10;14(4):435-9. Unique Identifier : AIDSLINE MED/20231316
- Ota MO; O'Donovan D; Alabi AS; Milligan P; Yamuah LK; N'Gom PT; Harding E; Ariyoshi K; Wilkins A; Whittle HC; Medical Research Council Laboratories, Fajara, Banjul, The; Gambia. Mota@mrc.gm
- OBJECTIVE: To compare the survival of children born to HIV-1 or HIV-2 seropositive mothers with that of children born to HIV-seronegative mothers and to evaluate risk factors for mortality. DESIGN: Physician-blinded prospective study. METHODS: One hundred and one HIV-1-seropositive, 243 HIV-2-seropositive pregnant wom
- Maternal plasma viral RNA levels determine marked differences in mother-to-child transmission rates of HIV-1 and HIV-2 in The Gambia. MRC/Gambia Government/University College London Medical School working group on mother-child transmission of HIV.
- AIDS. 2000 Mar 10;14(4):441-8. Unique Identifier : AIDSLINE MED/20231317
- O'Donovan D; Ariyoshi K; Milligan P; Ota M; Yamuah L; Sarge-Njie R; Whittle H; MRC Laboratories, Banjul, The Gambia.
- OBJECTIVES: To determine the rates of, and risk factors for, mother-to-child transmission (MCT) of HIV-1 and HIV-2 infection in The Gambia . DESIGN: A blinded, prospective, community-based cohort study of 29.549 pregnant women attending the eight largest antenatal clinics in The Gam
- Allelic frequencies of host genetic variants influencing susceptibility to HIV-1 infection and disease in South African populations.
- AIDS. 2000 Mar 10;14(4):449-51. Unique Identifier : AIDSLINE MED/20231318
- Williamson C; Loubser SA; Brice B; Joubert G; Smit T; Thomas R; Visagie M; Cooper M; van der Ryst E; SAIMR Virology, Department of Medical Microbiology, University of; Cape Town, Observatory, South Africa.
- OBJECTIVES: Limited information is available on the prevalence in African populations of host genetic polymorphisms conferring resistance to HIV-1 infection and disease. The objective of this study was to determine the allelic frequencies in South African populations of the chemokine receptor gene variants CCR5delta32
- Association of HIV-1 load and CD4 lymphocyte count with mortality among untreated African children over one year of age.
- Unique Identifier : AIDSLINE MED/20231319
- Taha TE; Kumwenda NI; Hoover DR; Biggar RJ; Broadhead RL; Cassol S; van der Hoven L; Markakis D; Liomba GN; Chiphangwi JD; Miotti PG; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.; ttaha@jhsph.edu
- OBJECTIVE: To examine the association of viral load and CD4 lymphocyte count with mortality among HIV-infected children over one year of age. DESIGN: A prospective study. HIV-infected children were enrolled during the first year of life and followed for more than 2 years at the Queen Elizabeth Central Hospital in Blan
- Carriage of Pneumocystis carinii by immunosuppressed patients and molecular typing of the organisms [letter]
- AIDS. 2000 Mar 10;14(4):461-3. Unique Identifier : AIDSLINE MED/20231320
- Hauser PM; Blanc DS; Bille J; Nahimana A; Francioli P
- The impact of co-infection with hepatitis C virus and HIV on the tolerability of antiretroviral therapy [letter]
- AIDS. 2000 Mar 10;14(4):463-5. Unique Identifier : AIDSLINE MED/20231321
- Melvin DC; Lee JK; Belsey E; Arnold J; Murphy RL
- Reversible acute haemolysis associated with indinavir [letter]
- AIDS. 2000 Mar 10;14(4):465-6. Unique Identifier : AIDSLINE MED/20231322
- Watson A
- Failure of a ritonavir plus saquinavir-based rescue regimen precludes the use of protease inhibitors [letter]
- AIDS. 2000 Mar 10;14(4):466-8. Unique Identifier : AIDSLINE MED/20231323
- Casado JL; Dronda F; Hertogs K; Antela A; Moreno S
- The development of lipodystrophy on a protease inhibitor-sparing highly active antiretroviral therapy regimen [letter]
- AIDS. 2000 Mar 10;14(4):468-9. Unique Identifier : AIDSLINE MED/20231324
- Leitz G; Robinson P
- Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir [letter]
- AIDS. 2000 Mar 10;14(4):469-71. Unique Identifier : AIDSLINE MED/20231325
- Van Laethem K; Witvrouw M; Balzarini J; Schmit JC; Sprecher S; Hermans P; Leal M; Harrer T; Ruiz L; Clotet B; Van Ranst M; Desmyter J; De Clercq E; Vandamme AM
- Heterosexual transmission of Kaposi's sarcoma-associated herpes virus between two patients developing AIDS-Kaposi's sarcoma [letter]
- AIDS. 2000 Mar 10;14(4):471-2. Unique Identifier : AIDSLINE MED/20231326
- Masquelier B; Boralevi F; Mercie P; Dupon M; Fleury HJ
- L-Carnitine as a treatment of life-threatening lactic acidosis induced by nucleoside analogues [letter]
- AIDS. 2000 Mar 10;14(4):472-3. Unique Identifier : AIDSLINE MED/20231327
- Claessens YE; Cariou A; Chiche JD; Dauriat G; Dhainaut JF
- Peripheral blood natural killer cell reconstitution after highly active antiretroviral therapy [letter]
- AIDS. 2000 Mar 10;14(4):473-4. Unique Identifier : AIDSLINE MED/20231328
- Villanueva JL; Caballero J; Del Nozal M; Sanchez B; Viciana P; Alarcon A; Pena J
- Association of antiretroviral therapy with detection of HIV-1 RNA and DNA in the anorectal mucosa of homosexual men.
- AIDS. 2000 Mar 31;14(5):F69-75. Unique Identifier : AIDSLINE MED/20241620
- Lampinen TM; Critchlow CW; Kuypers JM; Hurt CS; Nelson PJ; Hawes SE; Coombs RW; Holmes KK; Kiviat NB; Department of Epidemiology, Center for AIDS & STD, University of; Washington, Seattle 98195, USA.
- OBJECTIVE: To determine whether combination antiretroviral therapy is associated with reduced detection of HIV-1 RNA and DNA in the anorectal mucosa of men who have sex with men (MSM). DESIGN: Cross-sectional study of 233 MSM recruited from community and clinic sites in Seattle, Washington between July 1996 and Decemb
- HIV-1 Tat increases endothelial solute permeability through tyrosine kinase and mitogen-activated protein kinase-dependent pathways.
- AIDS. 2000 Mar 31;14(5):475-82. Unique Identifier : AIDSLINE MED/20241621
- Oshima T; Flores SC; Vaitaitis G; Coe LL; Joh T; Park JH; Zhu Y; Alexander B; Alexander JS; Department of Molecular and Cellular Physiology, Louisiana State; University Health Science Center, Shreveport 71130-3932, USA.
- OBJECTIVE: HIV-1 infection is associated with alterations of several vascular endothelial functions including adhesion molecule expression, growth, and vascular permeability. The bases of these errors are not known, but might involve secretion of the HIV-1 derived transcription factor Tat-1 . This study investigated
- Global distribution of the CCR2-64I/CCR5-59653T HIV-1 disease-protective haplotype.
- AIDS. 2000 Mar 31;14(5):483-9. Unique Identifier : AIDSLINE MED/20241622
- Martinson JJ; Hong L; Karanicolas R; Moore JP; Kostrikis LG; Department of Biological Anthropology, Oxford University, UK.
- OBJECTIVES: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. The CCR2-64I genetic variant [a G to A substitution resulting in a valine (V) to isoleucine (I) change at position 64] is in strong linkage disequilibrium with a mutation within
- Factors associated with the successful modification of antiretroviral therapy. HIV Outpatient Study Investigators.
- AIDS. 2000 Mar 31;14(5):491-7. Unique Identifier : AIDSLINE MED/20241623
- Weidle PJ; Lichtenstein KA; Moorman AC; Von Bargen JC; Greenberg KS; Palella FJ Jr; Holmberg SD; Epidemiology Branch, Division of HIV/AIDS Prevention Surveillance; and Epidemiology, National Center for HIV, STD, and TB; Prevention, Centers for Disease Control, Atlanta, GA 30333, USA.; pew6@cdc.gov
- OBJECTIVES: To assess the characteristics of medication regimen modification and the influence of a commercial genotypic resistance assay on the short-term (3-12 weeks) viral load response (> or = 0.5 log reduction) in HIV-1-infected patients extensively treated with antiretroviral therapy (ART). METHODS: A nested coh
- Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naive patients. I.CO.N.A. Study Group. Italian Cohort of Antiretroviral-Naive Patients.
- AIDS. 2000 Mar 31;14(5):499-507. Unique Identifier : AIDSLINE MED/20241624
- d'Arminio Monforte A; Lepri AC; Rezza G; Pezzotti P; Antinori A; Phillips AN; Angarano G; Colangeli V; De Luca A; Ippolito G; Caggese L; Soscia F; Filice G; Gritti F; Narciso P; Tirelli U; Moroni M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy. adarmin@tin.it
- OBJECTIVE: To evaluate the frequency of discontinuation of the first highly active antiretroviral regimen (HAART) and the factors predictive of discontinuing for toxicity and failure in a population-based cohort of HIV-positive individuals in Italy , naive from antiretrovirals at enr
- Oral zidovudine during labor to prevent perinatal HIV transmission, Bangkok: tolerance and zidovudine concentration in cord blood. Bangkok Collaborative Perinatal HIV Transmission Study Group.
- AIDS. 2000 Mar 31;14(5):509-16. Unique Identifier : AIDSLINE MED/20241625
- Bhadrakom C; Simonds RJ; Mei JV; Asavapiriyanont S; Sangtaweesin V; Vanprapar N; Moore KH; Young NL; Hannon WH; Mastro TD; Shaffer N; Siriraj Hospital Faculty of Medicine, Siriraj Hospital, Bangkok,; Thailand.
- OBJECTIVES: To evaluate tolerance for the oral administration of zidovudine (ZDV) during labor and measure the resulting ZDV concentrations in umbilical cord blood. DESIGN: A cross-sectional study of women in a placebo-controlled trial of short-course ZDV (twice a day from 36 weeks gestation until labor and every 3 h
- Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients.
- AIDS. 2000 Mar 31;14(5):517-24. Unique Identifier : AIDSLINE MED/20241626
- Anduze-Faris BM; Fillet AM; Gozlan J; Lancar R; Boukli N; Gasnault J; Caumes E; Livartowsky J; Matheron S; Leport C; Salmon D; Costagliola D; Katlama C; Department of Maladies Infectieuses et Tropicales, Hopital; Pitie-Salpetriere, Paris, France.
- OBJECTIVE: To evaluate the efficacy and safety of the foscarnet-ganciclovir combination in induction therapy (IT) and maintenance therapy (MT) for cytomegalovirus ( CMV ) central neurological disorders in HIV-infected patients.
- Predictors of tuberculosis transmission in prisons: an analysis using conventional and molecular methods.
- AIDS. 2000 Mar 31;14(5):525-35. Unique Identifier : AIDSLINE MED/20241627
- March F; Coll P; Guerrero RA; Busquets E; Cayla JA; Prats G; Department of Microbiology, Hospital de la Santa Creu i Sant Pau,; Barcelona, Spain.
- OBJECTIVE: To determine the tuberculosis (TB) transmission patterns within the prison system in Catalonia, conventional epidemiological techniques were combined with DNA fingerprinting of Mycobacterium tuberculosis. METHODS: IS6110- and polymorphic GC-rich repeat sequence (PGRS)-based restriction fragment length polym
- Partner type and condom use.
- AIDS. 2000 Mar 31;14(5):537-46. Unique Identifier : AIDSLINE MED/20241628
- Macaluso M; Demand MJ; Artz LM; Hook EW 3rd; Department of Epidemiology and International Health, School of; Public Health, University of Alabama at Birmingham, USA.
- OBJECTIVES: To examine the association between type of sexual partnership and condom use consistency. DESIGN: A prospective follow-up study of women attending two urban clinics for sexually transmitted diseases (STD). METHODS: Sexual diaries recording barrier method, partner initials and partner type for each act of i
- Repeat HIV testing: high-risk behaviour or risk reduction strategy?
- AIDS. 2000 Mar 31;14(5):547-52. Unique Identifier : AIDSLINE MED/20241629
- Leaity S; Sherr L; Wells H; Evans A; Miller R; Johnson M; Elford J; Royal Free Hampstead NHS Trust Hospital, UK.
- OBJECTIVE: To examine the characteristics of repeat and first-time HIV testers and consider their implications for HIV test counselling. METHODS: An anonymous questionnaire was completed by nearly 1500 people seeking an HIV test between September 1997 and July 1998 at a same-day HIV testing clinic in London,
- Cancer risk among men with, or at risk of, HIV infection in southern Europe.
- AIDS. 2000 Mar 31;14(5):553-9. Unique Identifier : AIDSLINE MED/20241630
- Serraino D; Boschini A; Carrieri P; Pradier C; Dorrucci M; Dal Maso L; Ballarini P; Pezzotti P; Smacchia C; Pesce A; Ippolito G; Franceschi S; Rezza G; Centro di Riferimento AIDS e Servizio di Epidemiologia delle; Malattie Infettive, IRCCS Lazzaro Spallanzani, Rome, Italy.
- OBJECTIVE: To evaluate the cancer risk in southern European men with, or at risk of, HIV infection. DESIGN: An analysis of longitudinal data to assess time-dependent rare events. METHODS: Data from a cohort of HIV seroconverters, and from two hospital-based HIV seroprevalent cohorts were combined and analysed. The num
- Ten-year trends in CD4 cell counts at HIV and AIDS diagnosis in a London HIV clinic.
- AIDS. 2000 Mar 31;14(5):561-71. Unique Identifier : AIDSLINE MED/20241631
- Easterbrook PJ; Yu LM; Goetghebeur E; Boag F; McLean K; Gazzard B; Department of HIV and Genitourinary Medicine, Chelsea and; Westminster Hospital, London, UK.
- OBJECTIVE: To examine temporal trends (1986-1996) in the CD4 cell count at first HIV-1 positive test and initial AIDS diagnosis, and the influence of selected patient characteristics and treatment factors on these trends. DESIGN: A retrospective clinic-based study. SETTING: Three hospital-based clinics in West London.
- Model-based evaluation of single-round mass treatment of sexually transmitted diseases for HIV control in a rural African population.
- AIDS. 2000 Mar 31;14(5):573-93. Unique Identifier : AIDSLINE MED/20241632
- Korenromp EL; Van Vliet C; Grosskurth H; Gavyole A; Van der Ploeg CP; Fransen L; Hayes RJ; Habbema JD; Department of Public Health, Erasmus University, Rotterdam, The; Netherlands. korenromp@mgz.fgg.eur.nl
- OBJECTIVES: To compare the impact of single-round mass treatment of sexually transmitted diseases (STD), sustained syndromic treatment and their combination on the incidence of HIV in rural Africa. METHODS: We studied the effects of STD interventions by stochastic simulation using the model STDSIM. Parameters were fit
- Sexually transmitted infections in European HIV-infected women: incidence in relation to time from infection. European Study on the Natural History of HIV Infection in Women.
- AIDS. 2000 Mar 31;14(5):595-603. Unique Identifier : AIDSLINE MED/20241633
- van Benthem BH; Prins M; Larsen C; Delmas MC; Brunet JB; van den Hoek A; Municipal Health Service, Division of Public Health and; Environment, Amsterdam, The Netherlands.; bvbenthem@gggd.amsterdam.nl
- OBJECTIVES: To investigate the prevalence and incidence of sexually transmitted infections (STI) in HIV-infected women in relation to time from infection and sexual behaviour. DESIGN: The European study on the natural history of HIV infection in women is a prospective cohort study of 487 HIV-infected women with a know
- The effect of syringe exchange use on high-risk injection drug users: a cohort study.
- AIDS. 2000 Mar 31;14(5):605-11. Unique Identifier : AIDSLINE MED/20241634
- Bluthenthal RN; Kral AH; Gee L; Erringer EA; Edlin BR; Drug Policy Research Center and Health Program, RAND, Santa; Monica, California 90407-2138, USA. Ricky_Bluthenthal@rand.org
- OBJECTIVE: To determine whether syringe exchange program use is associated with cessation of syringe sharing among high-risk injection drug users. DESIGN AND METHODS: Between 1992 and 1996, street-recruited injection drug users were interviewed and received HIV testing and counseling semi-annually, as part of a dynami
- Opposite effects of IFN-gamma on CCR5 and CXCR4 expression and on entry of M- and T-tropic HIV in epithelial cells [letter]
- AIDS. 2000 Mar 31;14(5):613-5. Unique Identifier : AIDSLINE MED/20241635
- Biolchini A; Curreli S; Ziccheddu M; Serra C; Dolei A
- Increased incidence of peripheral neuropathy with co-administration of stavudine and isoniazid in HIV-infected individuals [letter]
- AIDS. 2000 Mar 31;14(5):615. Unique Identifier : AIDSLINE MED/20241636
- Breen RA; Lipman MC; Johnson MA
- The costs of antiretroviral drug wastage [letter]
- AIDS. 2000 Mar 31;14(5):616-7. Unique Identifier : AIDSLINE MED/20241637
- Ostrop NJ; Gill MJ
- Immune recovery inflammatory folliculitis [letter]
- AIDS. 2000 Mar 31;14(5):617-8. Unique Identifier : AIDSLINE MED/20241638
- Bouscarat F; Maubec E; Matheron S; Descamps V
- Pharmacokinetics of efavirenz in a patient on maintenance haemodialysis [letter]
- AIDS. 2000 Mar 31;14(5):618-9. Unique Identifier : AIDSLINE MED/20241639
- Izzedine H; Aymard G; Launay-Vacher V; Hamani A; Deray G
- Effects of hydroxyurea on T cell count changes during primary HIV infection [letter]
- AIDS. 2000 Mar 31;14(5):619-22. Unique Identifier : AIDSLINE MED/20241640
- Ravot E; Tambussi G; Jessen H; Tinelli C; Lazzarin A; Lisziewicz J; Lori F
- Cidofovir ocular toxicity is related to previous ocular history [letter]
- AIDS. 2000 Mar 31;14(5):622-3. Unique Identifier : AIDSLINE MED/20241641
- Labetoulle M; Goujard C; Frau E; Offret H; Delfraissy JF; Gasnault J
- Detection of maternal DNA in cord blood at birth after elective caesarean section or vaginal delivery [letter]
- AIDS. 2000 Mar 31;14(5):623-5. Unique Identifier : AIDSLINE MED/20241642
- Semprini AE; De Andreis C; Fiore S; Garagiola I; Sirchia SM; Savasi V; Newell ML; Simoni G
- HIV/sexually transmitted disease education and prevention in US bathhouse and sex club environments [letter]
- AIDS. 2000 Mar 31;14(5):625-6. Unique Identifier : AIDSLINE MED/20241643
- Woods WJ; Binson DK; Mayne TJ; Gore LR; Rebchook GM
- Phenotypic resistance to protease inhibitors in patients who fail on highly active antiretroviral therapy predicts the outcome at 48 weeks of a five-drug combination including ritonavir, saquinavir and efavirenz [letter]
- AIDS. 2000 Mar 31;14(5):626-8. Unique Identifier : AIDSLINE MED/20241644
- Piketty C; Race E; Castiel P; Belec L; Peytavin G; Si-Mohamed A; Gonzalez-Canali G; Weiss L; Clavel F; Kazatchkine MD
- AIDS among Asians and Pacific Islanders in the United States.
- Am J Prev Med. 2000 Apr;18(3):208-14. Unique Identifier : AIDSLINE MED/20189802
- Wortley PM; Metler RP; Hu DJ; Fleming PL; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia, USA.; pmw1@cdc.gov
- OBJECTIVE: To characterize Asians and Pacific Islanders in the United States with reported acquired immunodeficiency syndrome (AIDS). METHODS: AIDS surveillance data reported through June 1998 were analyzed. Characteristics of cumulative case patients, rates of AIDS incidence in 1996 t
- Acute myelogenous leukaemia and myelomonocytic blast crisis following polycythemia vera in HIV positive patients: report of cases and review of the literature.
- Ann Oncol. 2000 Feb;11(2):195-200. Unique Identifier : AIDSLINE MED/20222392
- Hentrich M; Rockstroh J; Sandner R; Brack N; Hartenstein R; Department of Medicine IV, Munich-Harlaching City Hospital,; Academic Teaching Hospital of the Ludwig-Maximilians University; of Munich, Germany.
- BACKGROUND: Acute myelogenous leukaemia (AML) and myeloproliferative diseases are rare in HIV-infected individuals and optimal treatment has not been defined. PATIENTS AND METHODS: We report on the cases of two HIV-infected men, one with AML and one with myeloid blast crisis after polycythaemia vera (PV). A comprehens
- Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394.
- Biochemistry. 2000 Apr 18;39(15):4276-87. Unique Identifier : AIDSLINE MED/20222962
- Lightning LK; Jones JP; Friedberg T; Pritchard MP; Shou M; Rushmore TH; Trager WF; Department of Medicinal Chemistry, University of Washington, Box; 357610, Seattle, Washington 98195, USA.
- Mechanism-based inactivation of human liver P450 3A4 by L-754,394, a Merck compound synthesized as a potential HIV protease inhibitor, was investigated using recombinant P450 3A4. Enzyme inactivation was characterized by a small partition ratio (3.4 or 4.3 +/- 0.4), i.e., the total number of metabolic events undergone
- Elucidation of distinct ligand binding sites for cytochrome P450 3A4.
- Biochemistry. 2000 May 23;39(20):5929-39. Unique Identifier : AIDSLINE MED/20281314
- Hosea NA; Miller GP; Guengerich FP; Department of Biochemistry and Center in Molecular Toxicology,; Vanderbilt University School of Medicine, Nashville, Tennessee; 37232-0146, USA.
- Cytochrome P450 (P450) 3A4 is the most abundant human P450 enzyme and has broad selectivity for substrates. The enzyme can show marked catalytic regioselectivity and unusual patterns of homotropic and heterotropic cooperativity, for which several models have been proposed. Spectral titration studies indicated one bind
- Expanding the scope of HIV prevention for adolescents: beyond individual-level interventions [editorial]
- J Adolesc Health. 2000 Jun;26(6):377-8. Unique Identifier : AIDSLINE MED/20283305
- DiClemente RJ; Wingood GM; Emory University, Atlanta, Georgia, USA.
- [Fever with exanthema and meningism: a form of presentation of acute human immunodeficiency virus infection (letter)]
- An Med Interna. 2000 Feb;17(2):106. Unique Identifier : AIDSLINE MED/20288281
- Bataller Alberola L; Lopez Aldeguer J; Blanes Julia M; Caballero Cavaller M
- Proinflammatory and regulatory cytokine levels in AIDS cachexia.
- In Vivo. 1999 Nov-Dec;13(6):499-502. Unique Identifier : AIDSLINE MED/20220543
- Baronzio G; Zambelli A; Comi D; Barlocco A; Baronzio A; Marchesi P; Gramaglia A; Castiglioni E; Mafezzoni A; Beviglia E; Crespi F; Cargnel AI; Pravettoni G; Hyperthermia and Oncology Session, Centri Clinici Chirurgici; Padre Pio, Va, Italy. barongf@infoplus.it
- The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflammatory cytokines (In
- Effects of proton and gamma radiation on lymphocyte populations and acute response to antigen.
- In Vivo. 1999 Nov-Dec;13(6):525-33. Unique Identifier : AIDSLINE MED/20220548
- Kajioka EH; Gheorghe C; Andres ML; Abell GA; Folz-Holbeck J; Slater JM; Nelson GA; Gridley DS; Department of Radiation Medicine (Radiobiology Program), Loma; Linda University School of Medicine, CA 92354, USA.
- BACKGROUND: The clinical use of proton radiation in the management of cancer, as well as benign disorders, is rapidly increasing. The major goal of this study was to compare the effects of proton and gamma (60Co) radiation on cell-mediated and humoral immunological parameters. MATERIALS AND METHODS: C57BL/6 mice were
- Partial review of immunotherapeutic pharmacology in stem cell transplantation.
- In Vivo. 2000 Jan-Feb;14(1):221-36. Unique Identifier : AIDSLINE MED/20220580
- Bierman PJ; Abe F; Buyukberber S; Ino K; Talmadge JE; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198-5660, USA.
- In two separate lymphoma populations, we examined immune reconstitution following high dose chemotherapy (HDT) and bone marrow transplantation (BMT). In the first study we followed immune reconstitution for one year after HDT and BMT. In the second study we examined the ability of the orally active immunomodulator, Be
- Increased natural killer-cell mobilization and cytotoxicity during marital conflict.
- Brain Behav Immun. 2000 Mar;14(1):10-26. Unique Identifier : AIDSLINE MED/20195487
- Dopp JM; Miller GE; Myers HF; Fahey JL; Department of Microbiology and Immunology, CIRID, UCLA, Los; Angeles, California, 90096, USA. jdopp@mednet.ucla.edu
- Natural killer (NK) cells are reproducibly mobilized into the circulation in response to intense physical exercise or acute psychological stress, and altered expression of adhesion molecules potentially contributes to NK-cell mobilization. Studies of leukocyte mobilization during acute stress have used psychological s
- Who believes in "communication"? The Norman Cousins Lecture, 1999.
- Brain Behav Immun. 2000 Mar;14(1):2-9. Unique Identifier : AIDSLINE MED/20195486
- Heijnen CJ; Department of Pediatric Immunology, Section of; Psychoneuroimmunology, Wilhelmina Children Hospital of the; University Medical Center Utrecht, 3584 EA, Utrecht, The; Netherlands.
- Indeterminate results in blood donor testing: what you don't know can hurt you.
- Transfus Med Rev. 2000 Apr;14(2):151-60. Unique Identifier : AIDSLINE MED/20244356
- Dodd RY; Stramer SL; Transmissible Diseases Department, American Red Cross, Jerome H.; Holland Laboratory, Rockville, MD 20855, USA.
- HIV-1 gp41 by N-domain binds the potential receptor protein P45.
- Unique Identifier : AIDSLINE MED/20195502
- Xiao Y; Wu W; Dierich MP; Chen Y; Laboratory of Immunology, Research Centre for Medical Science,; and School of Life Science and Engineering, Tsinghua University,; Beijing, PR China.
- Recent crystal structure analysis of HIV-1 gp41 revealed that two domains (N- and C-domains) on gp41 play an important role in mediating membrane fusion and HIV-1 entry. The experimental evidence that gp41 by N-domain bound the potential receptor protein P45 could help to understand the mechanism of HIV entry. A recom
- Point-of-care HIV testing using simple/rapid HIV test kits: guidance for health-care professionals.
- Can Commun Dis Rep. 2000 Apr 1;26(7):49-59. Unique Identifier : AIDSLINE MED/20286097
- Kilby DL; Major CJ; Steben MH; Sutherland WD; Bally GA; Central Public Health Laboratory, Etobicoke, Ontario.
- Modulators of tumor necrosis factor alpha production bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.
- Biol Pharm Bull. 2000 Apr;23(4):513-6. Unique Identifier : AIDSLINE MED/20245025
- Tsuji M; Koiso Y; Takahashi H; Hashimoto Y; Endo Y; Graduate School of Pharmaceutical Sciences, University of Tokyo,; Japan.
- Previous studies on the structural development of tumor necrosis factor alpha (TNF-alpha) production regulators derived from thalidomide (N-alpha-phthalimidoglutarimide) revealed that a hydrophobic substituent at the nitrogen atom of the phthalimide ring is critical for potent activity. We have designed and prepared p
- The pattern and level of cytokines secreted by Th1 and Th2 lymphocytes of syphilitic patients correlate to the progression of the disease.
- FEMS Immunol Med Microbiol. 2000 May;28(1):1-14. Unique Identifier : AIDSLINE MED/20231500
- Podwinska J; Lusiak M; Zaba R; Bowszyc J; Institute of Immunology and Experimental Therapy, Polish Academy; of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.; podwinsk@immuno.iitd.pan.wroc.pl
- The results of our previous work indicated that cell-mediated immune response, of importance in protection against Treponema pallidum, is distinctly inhibited at certain periods of syphilitic infection. Considering that cytokines, produced by Th1 lymphocytes, take part in this response and that their secretion may be
- HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks.
- FEMS Immunol Med Microbiol. 2000 May;28(1):87-9. Unique Identifier : AIDSLINE MED/20231510
- Papa A; Papadimitriou E; Adwan G; Clewley JP; Malissiovas N; Ntoutsos I; Alexiou S; Antoniadis A; National AIDS Reference Laboratory of Northern Greece, Department; of Microbiology, School of Medicine, Aristotelian University of; Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
- The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.05
- [Screening for markers of infections transmitted by transfusions in the blood collected in France from 1996 to 1998]
- Transfus Clin Biol. 2000 Apr;7(2):153-70. Unique Identifier : AIDSLINE MED/20272539
- Courouce AM; Pillonel J; Saura C; Institut national de la transfusion sanguine, Paris, France.
- From 1996 to 1998, a decrease in positive donation rates has been observed for HIV, HCV and HBs Ag in first-time donors, while these rates remained stable for HTLV. In repeat donors, the same decrease was observed for HCV and HBs Ag while the rates remained stable for HIV. No HTLV-positive donations from repeat donors
- The increasing marginal benefit of condom usage.
- Ann Epidemiol. 2000 Apr;10(3):154-9. Unique Identifier : AIDSLINE MED/20271616
- Chesson HW; Gift TL; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.
- PURPOSE: Condom use is promoted as a primary strategy for preventing sexual transmission of human immunodeficiency virus (HIV). This paper analyzes how incremental changes in condom compliance rates can affect an individual s risk of acquiring HIV. METHODS: We developed a simple mathematical model of HIV transmission
- Recruitment maneuvers in three experimental models of acute lung injury. Effect on lung volume and gas exchange.
- Am J Respir Crit Care Med. 2000 May;161(5):1485-94. Unique Identifier : AIDSLINE MED/20268054
- Kloot TE; Blanch L; Melynne Youngblood A; Weinert C; Adams AB; Marini JJ; Shapiro RS; Nahum A; Department of Pulmonary and Critical Care Medicine, University of; Minnesota, Regions Hospital, St. Paul, Minnesota, USA.
- Recruitment maneuvers (RM), consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in acute respiratory distress syndrome (ARDS). We studied the effect of baseline ventilatory strategy and RM on end-expiratory lung volume (EELV) and oxygenation in 18 do
- Thoracoabdominal compression and respiratory system compliance in HIV-infected infants.
- Am J Respir Crit Care Med. 2000 May;161(5):1567-71. Unique Identifier : AIDSLINE MED/20268067
- Platzker AC; Colin AA; Chen XC; Hiatt P; Hunter J; Koumbourlis AC; Schluchter MD; Ting A; Wohl ME; The Divisions of Pediatric Pulmonology, Childrens Hospital Los; Angeles, CA, USA. aplatzker@chla.usc.edu
- The thoracoabdominal compression technique (TAC) is used to measure expiratory flow in infants. We investigated whether TAC caused a change in total thoracic compliance (Crs), resistance (Rrs), and respiratory system time constant (Trs). We studied 41 infants (mean age, 12.4 mo; SD, 7.5) from five centers studying lon
- Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation.
- Curr Biol. 2000 Mar 23;10(6):325-8. Unique Identifier : AIDSLINE MED/20211956
- Agace WW; Amara A; Roberts AI; Pablos JL; Thelen S; Uguccioni M; Li XY; Marsal J; Arenzana-Seisdedos F; Delaunay T; Ebert EC; Moser B; Parker CM; Division of Rheumatology, Immunology and Allergy, Brigham and; Womens Hospital, Harvard Medical School, Boston 02115, USA.; william.agace@immuno.lu.se
- HIV particles that use the chemokine receptor CXCR4 as a coreceptor for entry into cells (X4-HIV) inefficiently transmit infection across mucosal surfaces [1], despite their presence in seminal fluid and mucosal secretions from infected individuals [2] [3] [4]. In addition, although intestinal lymphocytes are suscepti
- Antigen-specific regulation of T cell-mediated cytokine production.
- Immunity. 2000 May;12(5):451-7. Unique Identifier : AIDSLINE MED/20300364
- Slifka MK; Whitton JL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, California 92037, USA.
- CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.
- Immunity. 2000 May;12(5):495-503. Unique Identifier : AIDSLINE MED/20300368
- Cook DN; Prosser DM; Forster R; Zhang J; Kuklin NA; Abbondanzo SJ; Niu XD; Chen SC; Manfra DJ; Wiekowski MT; Sullivan LM; Smith SR; Greenberg HB; Narula SK; Lipp M; Lira SA; Department of Immunology, Schering-Plough Research Institute,; Kenilworth, New Jersey 07033, USA.
- Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer s patches. These mice
- Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction.
- Immunity. 2000 May;12(5):505-14. Unique Identifier : AIDSLINE MED/20300369
- Vezys V; Olson S; Lefrancois L; Department of Medicine, University of Connecticut Health Center,; Farmington 06030, USA.
- Reactivity to intestinal epithelium-specific antigen was studied by transgenic expression of cytosolic ovalbumin controlled by an enterocyte-specific promoter. Transferred OVA-specific CD8 cells (OT-I) preferentially expanded in mucosal lymphoid tissues and the epithelium but failed to cause tissue damage. In contrast
- Viral folliculitis.
- AIDS Patient Care STDS. 1999 Sep;13(9):513-6. Unique Identifier : AIDSLINE MED/20272910
- Weinberg JM; Turiansky GW; James WD; Department of Dermatology, St. Luke's-Roosevelt Hospital Center,; New York, New York, USA. jwein@bway.net
- Viral folliculitis is an infrequently reported entity. We describe two patients with viral folliculitides, including a case of herpetic sycosis caused by herpes simplex (HSV) and a case of herpes zoster (HZ) without blisters. Clinicians should consider viral etiologies in the differential diagnosis of superficial infe
- The use of antiretroviral agents in patients with renal insufficiency.
- Unique Identifier : AIDSLINE MED/20272911
- Ostrop NJ; Burgess E; Gill MJ
- Current guidelines for the dosing of antiretroviral agents in HIV-positive patients with renal insufficiency including those requiring dialysis are limited, as revealed by a literature search performed using Health Knowledge Network MEDLINE and HealthSTAR. Pharmacokinetic and chemical aspects were taken into considera
- HIV-associated malignancies in children.
- AIDS Patient Care STDS. 1999 Sep;13(9):527-33. Unique Identifier : AIDSLINE MED/20272912
- Mueller BU; Department of Pediatrics, Harvard Medical School, Children's; Hospital, Boston, Massachusetts, USA.; mueller_b@al.tch.harvard.edu
- The exact incidence of malignancies in HIV-infected children is not clear; however, an excess of non-Hodgkin s lymphomas (NHLs) and soft tissue tumors (leiomyosarcomas) is evident. The spectrum of diseases is slightly different in children compared to adults. For example, Kaposi s sarcoma (KS), although common in HIV-
- Barriers to adherence to highly active antiretroviral therapy as expressed by people living with HIV/AIDS.
- AIDS Patient Care STDS. 1999 Sep;13(9):535-44. Unique Identifier : AIDSLINE MED/20272913
- Proctor VE; Tesfa A; Tompkins DC; Department of Preventive Medicine, State University of New York; at Stony Brook, USA. NIBC1112@aol.com
- The primary objective of this study was to gain a clearer understanding of the barriers to adherence to highly active antiretroviral therapy (HAART) faced by people living with HIV/AIDS (PLWHIV/AIDS) on Long Island, New York. Focus group, a qualitative research method, was used to study these barriers. The study was c
- Talking about AIDS.
- AIDS Patient Care STDS. 1999 Sep;13(9):545-53. Unique Identifier : AIDSLINE MED/20272914
- Epstein RM; Frarey L; Beckman HB; Department of Family Medicine, University of Rochester School of; Medicine and Dentistry, Highland Hospital Primary Care Institute,; New York, USA. Ronald_Epstein@URMC.Rochester.edu
- Despite increased public and professional awareness, patients and physicians tend to avoid discussions about HIV. Empiric studies of patient-physician communication point to specific common communication breakdowns. These include lack of a good opening line, inappropriate context, awkward moments, vague language, and
- Psychological discomfort and mental illness in patients with AIDS: implications for home care.
- AIDS Patient Care STDS. 1999 Sep;13(9):555-64. Unique Identifier : AIDSLINE MED/20272915
- Pozzi G; Del Borgo C; Del Forno A; Genualdo A; Mannelli P; Fantoni M; Institute of Psychiatry and Psychology, Catholic University of; Sacro Cuore, School of Medicine Agostino Gemelli, Rome, Italy.; ginopoz@tin.it
- A chart review study of 100 consecutive AIDS patients cared for by our Home Care (HC) unit was performed. The main characteristics of the sample were: M/F ratio = 3/1; mean age = 39.7 +/- 6.6; mode of transmission = 56% intravenous drug users (IVDU); Centers For Disease Control (CDC) classification = 98% C3; mean leng
- HIV/AIDS case histories: diagnostic problems. Cryptococcoma of the lung.
- AIDS Patient Care STDS. 1999 Sep;13(9):565-6. Unique Identifier : AIDSLINE MED/20272916
- Godwin TA; New York Hospital Medical Center of Queens, USA.
- Norvir capsule approved [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):567. Unique Identifier : AIDSLINE MED/20272918
- NDA submitted for adefovir [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):567. Unique Identifier : AIDSLINE MED/20272917
- Ziagen cleared for Europe [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):567. Unique Identifier : AIDSLINE MED/20272919
- Phase II begins for T-20 [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):567-8. Unique Identifier : AIDSLINE MED/20272920
- New PI active against many strains [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):568. Unique Identifier : AIDSLINE MED/20272921
- LEUKINE maintains viral suppression and extends duration of antiretroviral therapy [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):568-9. Unique Identifier : AIDSLINE MED/20272922
- Metabolic profile of protease inhibitors studied [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):569-70. Unique Identifier : AIDSLINE MED/20272923
- PI trial seeks participants [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):570. Unique Identifier : AIDSLINE MED/20272924
- Lack of volunteers for vaccine [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):572. Unique Identifier : AIDSLINE MED/20272927
- Prevention programs producing positive results [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):573. Unique Identifier : AIDSLINE MED/20272930
- Community and school HIV prevention programs help [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):574. Unique Identifier : AIDSLINE MED/20272932
- Intensive control programs lead to TB decline [news]
- AIDS Patient Care STDS. 1999 Sep;13(9):574-5. Unique Identifier : AIDSLINE MED/20272933
- Polyhistidine-tagged hepatitis B core particles as carriers of HIV-1/gp120 epitopes of different HIV-1 subtypes.
- Biol Chem. 2000 Mar;381(3):231-43. Unique Identifier : AIDSLINE MED/20243088
- Wizemann H; Weiland F; Pfaff E; von Brunn A; Max-von-Pettenkofer-Institut, Lehrstuhl Virologie, Genzentrum,; Munchen Germany.
- The hepatitis B core antigen is a widely accepted carrier particle to enhance the immunogenicity of foreign epitopes. From electron cryomicroscopy, the immunodominant region between amino acid positions 79 to 81 is known to protrude from the surface of the shells. It can be replaced by heterologous sequences without i
- How HIV hijacks host cells [news]
- Mol Med Today. 2000 Apr;6(4):140. Unique Identifier : AIDSLINE MED/20207102
- Dorrell S
- Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates.
- Chem Biol. 2000 Mar;7(3):153-61. Unique Identifier : AIDSLINE MED/20180366
- Wurtz NR; Dervan PB; Arnold and Mabel Beckman Laboratories of Chemical Synthesis,; California Institute of Technology, Pasadena, CA 91125, USA.
- BACKGROUND: Pyrrole-imidazole polyamides are synthetic ligands that recognize predetermined sequences in the minor groove of DNA with affinities and specificities comparable to those of DNA-binding proteins. As a result of their DNA-binding properties, polyamides could deliver reactive moieties for covalent reaction a
- Measurement of thrombopoietic levels: clinical and biological relationships.
- Curr Opin Hematol. 2000 May;7(3):143-9. Unique Identifier : AIDSLINE MED/20246322
- Verbeek W; Faulhaber M; Griesinger F; Brittinger G; Department of Medicine, Georg August University, Gottingen,; Germany.
- Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a transl
- Primary CNS lymphoma associated with streptococcal abscess: an autopsy case.
- Brain Tumor Pathol. 1999;16(2):92-7. Unique Identifier : AIDSLINE MED/20208756
- Kano M; Watanabe M; Maeda M; Department of Neurosurgery, Chuno Hospital, Seki City, Gifu,; Japan.
- This report describes a case of streptococcal abscess in the nodules of a primary central nervous system (CNS) lymphoma. Magnetic resonance imaging (MRI) of the brain revealed multiple lesions with ringlike enhancement over the bilateral frontal, right temporal, and left parietal lobes. On admission, acute brain edema
- Recent studies on natural products as anti-HIV agents.
- Curr Med Chem. 2000 Jun;7(6):649-61. Unique Identifier : AIDSLINE MED/20169491
- Jung M; Lee S; Kim H; Department of Chemistry, Yonsei University, Seoul, Korea.; mkjung@alchemy.yonsei.ac.kr
- The discovery of medicinal agents capable of specifically inhibiting human immunodeficiency virus (HIV) is urgently needed due to its globally widespread infection. Most of clinically useful anti-HIV agents are nucleosides but their use is limited due to their severe toxicity and emerging drug resistance. More than 50
- p53 and thymic 'death by neglect': thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent.
- Cell Death Differ. 2000 Mar;7(3):241-9. Unique Identifier : AIDSLINE MED/20211989
- Rosenheimer-Goudsmid N; Haupt Y; Yefenof E; Zilberman Y; Guy R; The Lautenberg Center for General and Tumor Immunology, The; Hebrew University, Hadassah Medical School, Jerusalem, Israel.
- The involvement of the tumor suppressor protein, p53, in thymic epithelial cell-induced apoptosis of CD4+8+ (double positive) thymocytes, was studied in an in vitro model consisting of a thymic epithelial cell line (TEC) and thymocytes. p53 expression was not augmented in double positive (DP) thymocytes upon co-cultur
- Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses.
- Clin Immunol. 2000 May;95(2):145-55. Unique Identifier : AIDSLINE MED/20243912
- Utsunomiya T; Kobayashi M; Ito M; Pollard RB; Suzuki F; Division of Infectious Diseases, The University of Texas Medical; Branch, Galveston, Texas 77555-0835, USA.
- Compared with normal mice, MAIDS mice (mice infected with LP-BM5 murine leukemia virus) exhibited an increase up to 100 times greater in susceptibility to infection with Candida albicans. The impaired resistance of MAIDS mice to the infection was recovered to levels observed in normal mice by the administration of gly
- Insights into HIV-specific immune function: implications for therapy and prevention in the new millennium.
- Unique Identifier : AIDSLINE MED/20243904 P
- Moss RB; Jensen FC; Carlo DJ; The Immune Response Corporation, Carlsbad, California 92008, USA.
- Herpes simplex virus encephalitis: chronic progressive cerebral MRI changes despite good clinical recovery and low viral load - an experimental mouse study.
- Eur J Neurol. 1999 Sep;6(5):531-8. Unique Identifier : AIDSLINE MED/99388147
- Meyding-Lamade U; Lamade W; Kehm R; Oberlinner C; Fath A; Wildemann B; Haas J; Hacke W; Department of Neurology, University of Heidelberg, Heidelberg,; Germany.
- Cranial magnetic resonance imaging (MRI) is a sensitive diagnostic tool for the in vivo detection of morphological abnormalities in herpes simplex virus encephalitis (HSVE). We performed a long-term MRI study in a mouse model of HSVE. Cranial MRI findings were compared with the viral load within brain tissue, the pres
- Similar subcortical pattern of cognitive impairment in AIDS patients with and without dementia.
- Eur J Neurol. 2000 Mar;7(2):151-8. Unique Identifier : AIDSLINE MED/20270490
- Suarez SV; Stankoff B; Conquy L; Rosenblum O; Seilhean D; Arvanitakis Z; Lazarini F; Bricaire F; Lubetzki C; Hauw JJ; Dubois B; Laboratoire de Neuropathologie Raymond Escourolle, INSERM U.3650,; Paris, France.
- The aim of this study was to develop a series of neuropsychological tests that define the cortical and subcortical features of cognitive impairment and the characteristics of memory in demented and mildly cognitively impaired AIDS patients. We attempted to establish a usable method to assess and determine the type and
- Using viral load, CD4+ levels, and clinical response to guide antiviral therapy for HIV.
- Cleve Clin J Med. 2000 May;67(5):321, 325-8. Unique Identifier : AIDSLINE MED/20291651
- Calabrese LH; Department of Rheumatic and Immunologic Diseases, Cleveland; Clinic, USA. calabrl@ccf.org
- The decision to start or modify antiviral therapy in patients with human immunodeficiency virus (HIV) infection is not based on any single factor. Although HIV RNA levels are the primary guide to therapy, the CD4+ count and clinical response are also important.
- Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):107-18. Unique Identifier : AIDSLINE MED/20300543
- Van Laethem K; Van Vaerenbergh K; Schmit JC; Sprecher S; Hermans P; De Vroey V; Schuurman R; Harrer T; Witvrouw M; Van Wijngaerden E; Stuyver L; Van Ranst M; Desmyter J; De Clercq E; Vandamme AM; Rega Institute for Medical Research and University Hospitals,; Leuven, Belgium.
- The sensitivity and discriminatory power of the 151 and 215 amplification refractory mutation system (ARMS) were evaluated, and their performance for the detection of drug resistance in mixed genotypic populations of the reverse transcription (RT) gene of HIV-1 were compared with T7 sequencing, cycle sequencing, the l
- Survival and failure to thrive in the SIV-infected juvenile rhesus monkey.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):119-23. Unique Identifier : AIDSLINE MED/20300544
- Freeman LM; Mansfield KG; Lackner AA; Naumova EN; Gorbach SL; Department of Clinical Sciences, Tufts University School of; Veterinary Medicine, North Grafton, Massachusetts 01536, USA.; Lfreeman@infonet.tufts.edu
- In AIDS patients, wasting in adults and failure to thrive in children are common and devastating problems. Weight loss in rhesus macaques infected with simian immunodeficiency virus (SIV) has not been well characterized. The purpose of this study was to determine growth curves in SIV-infected juvenile macaques to dete
- HIV-1 RNA in plasma and genital tract secretions in women infected with HIV-1.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):124-31. Unique Identifier : AIDSLINE MED/20300545
- Kovacs A; Chan LS; Chen ZC; Meyer WA 3rd; Muderspach L; Young M; Anastos K; Levine AM; Maternal-Child HIV Management and Research Center, Los Angeles; County University of Southern California Medical Center,; University of Southern California School of Medicine, 90033, USA.
- To assess antiretroviral therapy, all compartments, including the genital tract, need to be evaluated. HIV-1 RNA was quantified in whole cervicovaginal lavage fluid (CVL) and plasma of 56 women and in the cellular and supernatant fractions of 27 of these women. Overall, we detected HIV-1 RNA in 59% of whole CVL sample
- High-dose saquinavir plus ritonavir: long-term efficacy in HIV-positive protease inhibitor-experienced patients and predictors of virologic response.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):132-8. Unique Identifier : AIDSLINE MED/20300546
- Paredes R; Puig T; Arno A; Negredo E; Balague M; Bonjoch A; Jou A; Tuldra A; Tural C; Sirera G; Veny A; Romeu J; Ruiz L; Clotet B; Retrovirology Laboratory Institut de Recerca de la SIDA-Caixa,; Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia,; Spain. univih@ns.hugtip.scs.es
- The year-long antiviral efficacy of a high-dose salvage regimen consisting of saquinavir (800 mg twice daily) plus ritonavir (400 mg twice daily) was evaluated in 58 HIV-positive patients who had seen no improvement under first-line protease inhibitor
- A novel genotype encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers high-level cross-resistance to nucleoside reverse transcriptase inhibitors. Abacavir CNA2007 International Study Group.
- Unique Identifier : AIDSLINE MED/20300547
- Rakik A; Ait-Khaled M; Griffin P; Thomas TA; Tisdale M; Kleim JP
- We investigated HIV-1 reverse transcriptase (RT) polymorphisms of plasma isolates from 98 HIV-1-infected study subjects with >2 years of antiretroviral therapy who were failing their current protease inhibitor (PI)-containing regimen. In 1 patient, we detected a virus with a heavily mutated beta3-beta4 connecting loop
- Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):146-54. Unique Identifier : AIDSLINE MED/20300548
- Ferrando SJ; Rabkin JG; Poretsky L; Department of Psychiatry, Cornell University Medical College, New; York, New York, USA.
- This study explored associations between serum dehydroepiandrosterone sulfate (DHEAS), free and total testosterone levels, and HIV illness markers, including viral load, and the behavioral problems of fatigue and depressed mood. Subjects were 169 HIV-positive men evaluated at baseline, 6, and 12 months for levels of D
- Bacteremia in HIV-infected patients: short-term predictors of mortality.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):155-60. Unique Identifier : AIDSLINE MED/20300549
- Omenaca C; Turett G; Yarrish R; Astiz M; Lin R; Kislak JW; Cadden J; Infectious Diseases, Saint Vincent's Hospital and Medical Center; of New York, New York Medical College, Valhalla 10011, USA.
- To identify characteristics associated with mortality in HIV-infected patients with bacteremia, 88 bacteremic episodes in 80 HIV-infected patients were prospectively identified over a 5-month period and observed for 30 days. Demographic, clinical, laboratory, and radiologic data were collected. Mean and median age was
- Prevalence and incidence of HIV among incarcerated and reincarcerated women in Rhode Island.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):161-6. Unique Identifier : AIDSLINE MED/20300550
- Rich JD; Dickinson BP; Macalino G; Flanigan TP; Towe CW; Spaulding A; Vlahov D; The Miriam Hospital/Brown University, Providence, Rhode Island; 02906, USA. Josiah_Rich@brown.edu
- This study explores recent temporal trends in HIV prevalence among women entering prison and the incidence and associated risk factors among women reincarcerated in Rhode Island. Results from mandatory HIV testing from 1992 to 1996 for all incarcerated women were examined. In addition, a case control study was conduct
- HIV-1 RNA levels in an African population-based cohort and their relation to CD4 lymphocyte counts and World Health Organization clinical staging.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):167-73. Unique Identifier : AIDSLINE MED/20300551
- Morgan D; Rutebemberwa A; Malamba S; Ross A; Whitworth J; Kaleebu P; Gotch F; Medical Research Council Programme on AIDS/Uganda Virus Research; Institute, Entebbe. mrc@starcom.co.ug
- Apart from a small number of reports from people who are based in hospitals, data on viral load in HIV-infected people in sub-Saharan Africa, where most infections occur, are lacking. We report serum HIV-1 RNA levels in a population-based cohort in rural Uganda using the nucleic ac
- High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):174-9. Unique Identifier : AIDSLINE MED/20300552
- Boni J; Pyra H; Gebhardt M; Perrin L; Burgisser P; Matter L; Fierz W; Erb P; Piffaretti JC; Minder E; Grob P; Burckhardt JJ; Zwahlen M; Schupbach J; Swiss National Center for Retroviruses, University of Zurich.
- HIV-1 subtypes were determined in newly diagnosed residents of Switzerland . Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened
- Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):180-8. Unique Identifier : AIDSLINE GENBANK/AF160754
- Yu XF; Chen J; Shao Y; Beyrer C; Liu B; Wang Z; Liu W; Yang J; Liang S; Viscidi RP; Gu J; Gurri-Glass G; Lai S; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA. xfyu@jhsph.edu
- Heroin users from Guangxi province, a southern province of China that borders Vietnam in the south and Yunnan province in China in the west, were studied for prevalence and risk factors for HIV-1 infection. Viral env sequences from HIV-1-positiv
- Predictive markers of HIV-related weight loss and determination of differences between populations with weight loss stratified by opportunistic processes.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):189-93. Unique Identifier : AIDSLINE MED/20300554
- Zackin RA; Clark RA; Currier JS; Mildvan D; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA. zackin@sdac.harvard.edu
- OBJECTIVE: To describe factors predictive of >10% weight loss among enrolled participants in clinical trials of the AIDS Clinical Trial Group (ACTG). DESIGN: A retrospective analysis of data from selected ACTG antiretroviral clinical trials completed prior to 1996 (ACTG 116, 117, 155, 175, and 241), which did not incl
- HIV-1 transmission in injection paraphernalia: heating drug solutions may inactivate HIV-1.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):194-9. Unique Identifier : AIDSLINE MED/20300555
- Clatts MC; Heimer R; Abdala N; Goldsamt LA; Sotheran JL; Anderson KT; Gallo TM; Hoffer LD; Luciano PA; Kyriakides T; National Development and Research Institutes, Inc., New York, New; York 10048, USA. michael.clatts@ndri.org
- In response to recent concerns about risk of HIV-1 transmission from drug injection paraphernalia such as cookers, ethnographic methods were used to develop a descriptive typology of the paraphernalia and practices used to prepare and inject illegal drugs. Observational data were then applied in laboratory studies in
- Molecular pathologic analysis of the tonsil in HTLV-I-infected individuals.
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):200-7. Unique Identifier : AIDSLINE MED/20300556
- Takenouchi N; Matsuoka E; Moritoyo T; Nagai M; Katsuta K; Hasui K; Ueno K; Eizuru Y; Usuku K; Osame M; Isashiki Y; Izumo S; Division of Molecular Pathology and Genetic Epidemiology, Center; for Chronic Viral Diseases, Kagoshima University School of; Medicine, Japan.
- Little is known about the role of the tonsils in HTLV-I infection. We performed molecular pathologic studies of tonsils in individuals positive or negative for anti-HTLV-I antibodies (HTLV-I-Ab) to clarify histologic characteristics of tonsils in HTLV-I infection. We collected tonsils and peripheral blood samples from
- Plasma RNA viral load as measured by the branched DNA and nucleic acid sequence-based amplification assays of HIV-1 subtypes A and D in Uganda [letter]
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):208-9. Unique Identifier : AIDSLINE MED/20300557
- Mani I; Cao H; Hom D; Johnson JL; Mugerwa RD; Travers KU; Caliendo AM; Walker BD; Kanki PJ
- Development of Kaposi's sarcoma despite sustained suppression of HIV plasma viremia [letter]
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):209-10. Unique Identifier : AIDSLINE MED/20300558
- Chan J; Kravcik S; Angel JB
- Mother-to-child HIV transmission. European Study Group on the Natural History of HIV Infection in Women [letter]
- J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):210-2. Unique Identifier : AIDSLINE MED/20300559
- Miller M
- Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry.
- J Biol Inorg Chem. 2000 Feb;5(1):67-74. Unique Identifier : AIDSLINE MED/20227519
- Cowan JA; Ohyama T; Howard K; Rausch JW; Cowan SM; Le Grice SF; Evans Laboratory of Chemistry, The Ohio State University,; Columbus 43210, USA. cowan@chemistry.ohio-state.edu
- Crystallographic studies of the Mn(2+)-doped RNase H domain of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) have revealed two bound Mn2+ separated by approximately 4A and surrounded by a cluster of four conserved carboxylates. Escherichia coli RNase H is structurally similar to the RNase H doma
- [Management of chronic tinnitus. Counseling--therapeutic apparatus--psychotherapy]
- MMW Fortschr Med. 2000 Feb 24;142(8):37-9. Unique Identifier : AIDSLINE MED/20271163
- Rosanowski F; Kollner V; Weber A; Eysholdt U; Abteilung fur Phoniatrie und Padaudiologie, Klinikum der; Universitat Erlangen-Nurnberg.
- Current and novel agents for the treatment of cytomegalovirus retinitis.
- Drugs R D. 1999 Nov;2(5):289-97. Unique Identifier : AIDSLINE MED/20192707
- Akerele T; Lightman S; Department of Clinical Ophthalmology, Institute of Ophthalmology,; London, England.
- The incidence of cytomegalovirus ( CMV ) retinitis appears to be declining with improved treatment protocols for HIV and prophylaxis protocols for other high risk patients. Despite this, CMV retinitis remains a major cause of v
- Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
- Drugs R D. 1999 Nov;2(5):303-5. Unique Identifier : AIDSLINE MED/20192709
- Benzimidavir. 1263W94, BW 1263W94, GW 1263.
- Drugs R D. 1999 Nov;2(5):306-7. Unique Identifier : AIDSLINE MED/20192710
- The emerging role of fusion inhibitors in HIV infection.
- Drugs R D. 1999 Nov;2(5):321-31. Unique Identifier : AIDSLINE MED/20192716
- De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. erik.declercq@rega.kuleuven.ac.be
- Fusion of HIV with its host cell requires the interaction of the viral envelope glycoprotein 120 (gp120) with the chemokine receptor CXCR4 [T cell-tropic (T-tropic) or X4 HIV strains] or CCR5 [macrophage-tropic (M-tropic) or R5 HIV strains] followed by a spring-loaded action of the glycoprotein 41 (gp41) that ensure
- Fusion inhibitors in HIV infection. Summary and table.
- Drugs R D. 1999 Nov;2(5):333-5. Unique Identifier : AIDSLINE MED/20192717
- Wilde M; Paterson R; Adis International Limited, Auckland, New Zealand.
- AMD 3100. JM 3100, SDZ SID 791.
- Drugs R D. 1999 Nov;2(5):337-9. Unique Identifier : AIDSLINE MED/20192718
- Dextrin-2-sulfate. D2S, Emmelle, Viraldon.
- Drugs R D. 1999 Nov;2(5):340-2. Unique Identifier : AIDSLINE MED/20192719
- FP 21399.
- Drugs R D. 1999 Nov;2(5):343-4. Unique Identifier : AIDSLINE MED/20192720
- ISIS 5320. NSC 665353.
- Drugs R D. 1999 Nov;2(5):345-6. Unique Identifier : AIDSLINE MED/20192721
- Pentafuside. DP 178, T 20.
- Drugs R D. 1999 Nov;2(5):347-9. Unique Identifier : AIDSLINE MED/20192722
- PRO 542. CD4 IgG2.
- Unique Identifier : AIDSLINE MED/20192723
- SPC 3.
- Drugs R D. 1999 Nov;2(5):352. Unique Identifier : AIDSLINE MED/20192724
- Kaposi's sarcoma-associated herpesvirus: from cell biology to pathogenesis.
- IUBMB Life. 2000 Feb;49(2):97-104. Unique Identifier : AIDSLINE MED/20238890
- Sharp TV; Boshoff C; Department of Oncology, University College London, United; Kingdom.
- Kaposi s sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi s sarcoma, a plasma-blastic variant of Castleman s disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He
- Laboratory methods of diagnosis of syphilis for the beginning of the third millennium.
- Microbes Infect. 1999 Oct;1(12):1035-49. Unique Identifier : AIDSLINE MED/20085399
- Wicher K; Horowitz HW; Wicher V; Wadsworth Center, New York State Department of Health, Albany,; NY, USA.
- Despite that the whole genome of T. pallidum, the causative agent of syphilis, has been sequenced, syphilis is, and will remain for some time, diagnosed by direct clinical observation and by laboratory methods. This review presents comprehensively most of the practical techniques used for direct detection of T. pallid
- Accumulation of MAC387+ macrophages in paracortical areas of lymph nodes in rhesus monkeys acutely infected with simian immunodeficiency virus.
- Microbes Infect. 1999 Oct;1(12):977-85. Unique Identifier : AIDSLINE MED/20085393
- Otani I; Mori K; Sata T; Terao K; Doi K; Akari H; Yoshikawa Y; Tsukuba Primate Center, National Institute of Infectious; Diseases, 1 Hachimandai, Tsukuba, Ibaraki 305-0843, Japan.
- We investigated the histological features of lymph nodes, focusing on monocytes/macrophages, in rhesus monkeys (Macaca mulatta) acutely infected with simian immunodeficiency virus (SIV). In monkeys infected with a pathogenic SIV, SIVmac239, MAC387(+) newly blood-derived macrophages markedly increased in number at para
- Evaluation of IgG, IgM, and IgA antibodies to mycoplasma penetrans detected by ELISA and immunoblot in HIV-1-infected and STD patients, in Sao Paulo, Prazil.
- Microbes Infect. 1999 Nov;1(13):1095-101. Unique Identifier : AIDSLINE MED/20249339
- de Cordova CM; Takei K; Rosenthal C; Miranda MA; Vaz AJ; da Cunha RA; Departamento de Analises Clinicas e Toxicologicas, Faculdade; de Ciencias Farmaceuticas, Universidade de Sao Paulo, SP,; Brazil.
- The aim of the present study was to determine the frequency of IgG, IgA, and IgM antibodies to Mycoplasma penetrans in HIV-1-infected patients and in patients with sexually transmitted diseases. We tested serum samples from 106 HIV-1-positive patients and 110 individuals with clinical symptoms of urethritis. ELISA and
- HIV-infected long-term nonprogressors: epidemiology, mechanisms of delayed progression, and clinical and research implications.
- Microbes Infect. 1999 Nov;1(13):1113-20. Unique Identifier : AIDSLINE MED/20249341
- Buchbinder S; Vittinghoff E; HIV Research Section, San Francisco Department of Public Health,; San Francisco, CA 94102, USA.
- Long-term nonprogressors (LTNPs) should be defined as untreated HIV-infected persons without AIDS and with high CD4(+) counts and low plasma viral loads 10 or more years after infection. Although no demographic or behavioral variables distinguish LTNPs, studies should be expanded to include geographically and ethnical
- Regulation of the immune response in experimental and human schistosomiasis: the limits of an attractive paradigm.
- Microbes Infect. 1999 Jun;1(7):485-90. Unique Identifier : AIDSLINE MED/20072912
- Capron A; Dombrowicz D; Capron M; U 167 INSERM, Institut Pasteur de Lille, 1, rue du Pr Calmette,; BP 245, 59019 Lille, France.
- Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology.
- Microbes Infect. 1999 Jun;1(7):525-34. Unique Identifier : AIDSLINE MED/20072918
- Wynn TA; The Schistosomiasis Immunology and Pathology Unit, Immunobiology; Section, Laboratory of Parasitic Diseases, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892, USA.
- HIV-based vectors: getting the best out of the worst [interview]
- J Gene Med. 2000 Jan-Feb;2(1):61-3. Unique Identifier : AIDSLINE MED/20228323
- Trono D
- A nationwide, multicenter, case-control study comparing risk factors, treatment, and outcome for vancomycin-resistant and susceptible enterococcal bacteremia.
- Diagn Microbiol Infect Dis. 2000 Mar;36(3):145-58. Unique Identifier : AIDSLINE MED/20195583
- Bhavnani SM; Drake JA; Forrest A; Deinhart JA; Jones RN; Biedenbach DJ; Ballow CH; The Clinical Pharmacokinetics Laboratory, Millard Fillmore; Hospital/Kaleida Health, Buffalo, New York, USA.; sbhavnan@mfhs.edu
- National Nosocomial Resistance Surveillance Group participants from 22 hospitals across the United States reviewed medical records for hospitalized patients with vancomycin-resistant enterococcal (VRE) or vancomycin-susceptible enterococcal (VSE) bacteremia to identify risk factors ass
- Clinical features and in vitro susceptibilities of two varieties of Cryptococcus neoformans in Taiwan.
- Diagn Microbiol Infect Dis. 2000 Mar;36(3):175-83. Unique Identifier : AIDSLINE MED/20195587
- Chen YC; Chang SC; Shih CC; Hung CC; Luhbd KT; Pan YS; Hsieh WC; Section of Infectious Diseases, Departments of Internal Medicine,; No. 7, National Taiwan University, Taipei, Taiwan, People's; Republic of China.
- One hundred years after introduction of the Eucalyptus tree to Taiwan , a predominantly subtropical island, we analyzed clinical and microbiological data of 59 patients with Cryptococcus neoformans infection hospitalized at National
- Treatment of sexually transmitted bacterial diseases in pregnant women.
- Drugs. 2000 Mar;59(3):477-85. Unique Identifier : AIDSLINE MED/20236588
- Donders GG; Department of Obstetrics and Gynecology, Gasthuisberg University; Hospital, Katholieke Universiteit Leuven, Belgium.; gilbert.donders@village.UUnet.be
- Testing for and treating sexually transmitted diseases (STDs) in pregnant women deserves special attention. Treatment possibilities are limited because of potential risks for the developing fetus, and because effects can differ in pregnant compared with non-pregnant women, re-infection may be missed because of the int
- Nelfinavir: an update on its use in HIV infection.
- Drugs. 2000 Mar;59(3):581-620. Unique Identifier : AIDSLINE MED/20236594
- Bardsley-Elliot A; Plosker GL; Adis International Limited, Mairangi Bay, Auckland, New Zealand.; demail@adis.co.nz
- Nelfinavir is one of several currently available protease inhibitors used to limit viral replication and improve immune function in HIV-infected individuals. It is administered in combination with other antiretroviral agents. Nelfinavir has been evaluated as first-l
- Interaction within clusters of dendritic cells and helper T cells during initial Th1/Th2 commitment.
- Eur J Immunol. 2000 May;30(5):1255-62. Unique Identifier : AIDSLINE MED/20281469
- Schuhbauer DM; Mitchison NA; Mueller B; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
- Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide
- IL-5 and eosinophils mediate the rejection of fully histoincompatible vascularized cardiac allografts: regulatory role of alloreactive CD8(+) T lymphocytes and IFN-gamma.
- Eur J Immunol. 2000 May;30(5):1290-6. Unique Identifier : AIDSLINE MED/20281473
- Braun MY; Desalle F; Le Moine A; Pretolani M; Matthys P; Kiss R; Goldman M; Laboratory of Experimental Immunology, Universite Libre de; Bruxelles, Brussels, Belgium. mbraun@ulb.ac.be
- CD8(+) T lymphocytes are known to inhibit the development of eosinophilia and IL-5 synthesis in models of experimental lung disease. In transplantation, the rejection of fully mismatched cardiac allografts by recipients depleted of CD8(+) T cells is characterized by the recruitment of eosinophils in the rejected organ
- Tumor size at the time of adoptive transfer determines whether tumor rejection occurs.
- Eur J Immunol. 2000 May;30(5):1297-307. Unique Identifier : AIDSLINE MED/20281474
- Cordaro TA; de Visser KE; Tirion FH; Graus YM; Haanen JB; Kioussis D; Kruisbeek AM; Division of Immunology, The Netherlands Cancer Institute,; Amsterdam, The Netherlands.
- Here we investigate the minimal requirements for induction of an anti-tumor response in CD8 T cells in vivo. We compare the efficacy of adoptive transfer of CD8 T cells with a transgenic TCR specific for the main cytotoxic T lymphocyte epitope of the influenza virus nucleoprotein (NP) on the growth of NP-expressing EL
- Survival and cytokine polarization of naive CD4(+) T cells in vitro is largely dependent on exogenous cytokines.
- Eur J Immunol. 2000 May;30(5):1308-17. Unique Identifier : AIDSLINE MED/20281475
- Ben-Sasson SZ; Makedonski K; Hu-Li J; Paul WE; The Lautenberg Center for General and Tumor Immunology, The; Hebrew University/Hadassah Medical Center, Jerusalem, Israel.
- Naive CD4(+) T cells differ from memory cells by their heightened expression of the disialoceramide recognized by antibody 3G11. 3G11(bright) cells respond well to immobilized anti-CD3 / anti-CD28 and to their cognate antigens but produce little or no IFN-gamma or IL-4 acutely and undergo cell death even in the pres
- IL-13 and TNF-alpha inhibit dual-tropic HIV-1 in primary macrophages by reduction of surface expression of CD4, chemokine receptors CCR5, CXCR4 and post-entry viral gene expression.
- Eur J Immunol. 2000 May;30(5):1340-9. Unique Identifier : AIDSLINE MED/20281479
- Bailer RT; Lee B; Montaner LJ; The Wistar Institute, Philadelphia, PA 19104, USA.
- We show that IL-13 in the presence of TNF-alpha effected an equal or greater antiviral activity against a dual-tropic HIV-1 (R5X4) in macrophages. A temporary or continued exposure of macrophages to both cytokines significantly decreased the infection and replication of R5X4 HIV-1(89.6) (median, 128-fold, n = 9, p = 0
- Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo.
- Eur J Immunol. 2000 May;30(5):1356-63. Unique Identifier : AIDSLINE MED/20281481
- Barchet W; Oehen S; Klenerman P; Wodarz D; Bocharov G; Lloyd AL; Nowak MA; Hengartner H; Zinkernagel RM; Ehl S; Institute of Experimental Immunology, Department of Pathology,; University of Zurich, Zurich, Switzerland.
- Lysis of infected cells by CD8(+) T cells is an important mechanism for the control of virus infections, but remains difficult to quantify in vivo. Here, we study the elimination kinetics of viral antigen-positive lymphocytes by antiviral CD8(+) T cells using flow cytometry and mathematical analysis. In mice acutely i
- Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells.
- Eur J Immunol. 2000 May;30(5):1364-74. Unique Identifier : AIDSLINE MED/20281482
- Wu CY; Gadina M; Wang K; O'Shea J; Seder RA; Clinical Immunology Section, Laboratory of Clinical; Investigation, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- The biological activities of IL-12 are mediated through a specific, high-affinity receptor composed of IL-12 receptor(R)beta1 and IL-12Rbeta2 subunits that exist primarily on T and NK cells. Remarkably, the expression of IL-12Rbeta2 on CD4(+) T cells in mouse and humans appears to be differentially regulated by IFN-ga
- Stat6 activation and Th2 cell proliferation driven by CD28 signals.
- Eur J Immunol. 2000 May;30(5):1416-24. Unique Identifier : AIDSLINE MED/20281488
- Oki S; Otsuki N; Kohsaka T; Azuma M; Department of Immunology, National Children's Medical Research; Center, Tokyo, Japan.
- CD28 engagement by specific monoclonal antibody (mAb) or binding of the natural ligands, CD80 and CD86, induces tyrosine phosphorylation of CD28, which in turn recruits and activates the signal transducer and activator of transcription 6 (Stat6). The Stat6 association with CD28 is specifically induced by CD80 or CD86
- Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice.
- Eur J Immunol. 2000 May;30(5):1486-95. Unique Identifier : AIDSLINE MED/20281496
- Camoglio L; te Velde AA; de Boer A; ten Kate FJ; Kopf M; van Deventer SJ; Laboratory of Experimental Internal Medicine, Academic Medical; Centre, University of Amsterdam, Amsterdam, The Netherlands.; L.Camoglio@AMC.UVA.NL
- IFN-gamma is a potent pro-inflammatory cytokine thought to be involved in the pathogenesis of Crohn s disease. To further define the role of IFN-gamma in intestinal inflammation, we studied the effects of intra-colonic 2,4,6-trinitrobenzene sulfonic acid (TNBS) instillation in mice with a functionally inactivated IFN-
- Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy.
- Hepatology. 2000 Jun;31(6):1318-26. Unique Identifier : AIDSLINE MED/20287462
- Yeh CT; Chien RN; Chu CM; Liaw YF; Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung; University School of Medicine, Taipei, Taiwan.; catyeh@ms14.hinet.net
- Tyrosine-methionine-aspartate-aspartate (YMDD)-motif mutants may emerge and elicit immune clearance during prolonged lamivudine treatment. The aim of this study was to investigate the virological events following development of the original mutants. Twenty-three patients who developed YMDD-motif mutants during the Asi
- Absence of human herpesvirus-8 DNA in Kaposi's sarcoma following postmastectomy lymphoedema [letter]
- Histopathology. 2000 May;36(5):474-5. Unique Identifier : AIDSLINE MED/20315493
- du Pleiss DG; Schneider JW; Treurnicht FK; Engelbrecht S; van Rensburg EJ
- Human immunodeficiency and hepatitis C virus coinfection influenced by interferon-gamma [letter]
- Immunol Lett. 2000 Mar 1;71(3):141-2. Unique Identifier : AIDSLINE MED/20319858
- Battegay M; Holdener M; Naef M; Wernli M
- Pediatric infectious diseases: future campaigns [editorial]
- Indian J Pediatr. 1995 Jan-Feb;62(1):1-2. Unique Identifier : AIDSLINE MED/20288647
- Kumar A; Chaudhary S
- Infants born to HIV-1 infected women: lessons from the past decade.
- Indian J Pediatr. 1995 Jan-Feb;62(1):17-24. Unique Identifier : AIDSLINE MED/20288649
- Kaul A; Chandwani S; Department of Pediatrics, New York University Medical Center, NY; 10016, USA.
- Epidemiology and prevention of AIDS in children.
- Indian J Pediatr. 1995 May-Jun;62(3):307-15. Unique Identifier : AIDSLINE MED/20288692
- Narain JP; Sodhi G; Global Programme on AIDS, World Health Organization, South-East; Asia Regional Office, New Delhi.
- Psycho-social aspects of childhood AIDS in developing countries.
- Indian J Pediatr. 1995 Jul-Aug;62(4):421-6. Unique Identifier : AIDSLINE MED/20288708
- John JK; Braganza D; Department of Psychiatry, Christian Medical College, Vellore,; Tamil Nadu.
- Management of tuberculosis.
- Indian J Pediatr. 1995 Sep-Oct;62(5):557-63. Unique Identifier : AIDSLINE MED/20288731
- Benakappa A; Benakappa N; Benakappa DG; Bangalore Medical College, Indira Gandhi Institute of Child; Health.
- Tuberculosis is a common disease in children but it is highly mismanaged. It is bound to be triggered off by HIV infection in the near future. The importance of HIV and TB has become apparent from the high incidence of disease caused by mycobacteria in AIDS patients. The injudicious use of needles and syringes should
- Nutrition and HIV infection in children.
- Indian J Pediatr. 1996 Sep-Oct;63(5):615-32. Unique Identifier : AIDSLINE MED/20288839
- Mannick EE; Udall JN; Kaiser M; Fuchs G; Suskind R; LSU Medical Center, Department of Pediatrics, New Orleans 70112,; USA.
- HIV infection has profound effects on a patient s nutritional status because it can modulate appetite, nutrient absorption and basal metabolic rate. In addition, HIV infection can lead to the depletion of a variety of vitamins and micronutrients including vitamins A, D, B2, B6, B12, L-carnitine, iron, zinc and seleniu
- Doxycycline sclerotherapy of benign lymphoepithelial cysts of the parotid: a minimally invasive treatment.
- Int J Pediatr Otorhinolaryngol. 2000 Apr 15;52(2):157-61. Unique Identifier : AIDSLINE MED/20231866
- Suskind DL; Tavill MA; Handler SD; Division of Otolaryngology, The Children's Hospital of; Philadelphia, 34th Street and Civic Center Boulevard,; Philadelphia, PA 19104, USA.
- Benign lymphoepithelial cysts (BLCs) of the parotid gland are associated with human immunodeficiency virus infections in both children and adults. These cysts may become painful and unsightly, often initiating a request for therapeutic intervention. There are several treatment options described in the literature. We r
- Effects of varying concentrations of bleach on in vitro HIV-1 replication and the relevance to injection drug use.
- Unique Identifier : AIDSLINE MED/20237694
- Contoreggi C; Jones S; Simpson P; Lange WR; Meyer WA 3rd; National Institutes of Health, National Institute on Drug Abuse,; Intramural Research Program, Baltimore, Md., USA.; ccontore@intra.nida.nih.gvo
- The use of bleach (hypochlorite) as a disinfectant for drug injection equipment in the intravenous-drug-using population was recommended early in the HIV-1/AIDS epidemic. Epidemiological studies have challenged the use of bleach as an effective measure to prevent HIV-1 transmission. However, in vitro HIV-1 coculture s
- Influence of viral load and alanine aminotransferase on viral genetic heterogeneity in patients with chronic hepatitis C virus infection.
- Intervirology. 2000;43(1):61-6. Unique Identifier : AIDSLINE MED/20237703
- Bozdayi AM; Uzunalimoglu O; Aslan N; Bozkaya H; Turkyilmaz AR; Kayhan B; Sahin T; Sivri B; Uygun A; Altiok A; Cetinkaya H; Karayalcin S; Yurdaydin C; Institute of Hepatology, Ankara University School of Medicine,; Ankara, Turkey. bozdayi@pallas.dialup.ankara.edu.tr
- BACKGROUND/AIM: Hepatitis C virus (HCV) populations in vivo consist of genetically different heterogeneous mixtures defined as quasispecies , which vary in the hypervariable region 1 (HVR1) mostly. To further address the role of quasispecies diversity in hepatitis C infection, this study aimed to evaluate the influen
- Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agents.
- J Antibiot (Tokyo). 2000 Mar;53(3):309-13. Unique Identifier : AIDSLINE MED/20277456
- Saito Y; Nakamura M; Ohno T; Chaicharoenpong C; Ichikawa E; Yamamura S; Kato K; Umezawa K; Department of Applied Chemistry, Faculty of Science and; Technology, Keio University, Yokohama, Japan.
- Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.
- J Biol Chem. 2000 May 19;275(20):14890-7. Unique Identifier : AIDSLINE MED/20270188
- Basrur V; Song Y; Mazur SJ; Higashimoto Y; Turpin JA; Rice WG; Inman JK; Appella E; Laboratory of Cell Biology, NCI, National Institutes of Health,; Bethesda, Maryland 20892, USA.
- The synthesis and antiviral properties of pyridinioalkanoyl thioester (PATE) compounds that target nucleocapsid p7 protein (NCp7) of the human immunodeficiency virus type 1 (HIV-1) have been described previously (Turpin, J. A., Song, Y., Inman, J. K., Huang, M., Wallqvist, A., Maynard, A., Covell, D. G., Rice, W. G.,
- S-adenosylmethionine and Pneumocystis carinii.
- J Biol Chem. 2000 May 19;275(20):14958-63. Unique Identifier : AIDSLINE MED/20270197
- Merali S; Vargas D; Franklin M; Clarkson AB Jr; Department of Medical and Molecular Parasitology, New York; University School of Medicine, New York, New York 10010, USA.; merals01@popmail.med.nyu.edu
- We previously reported that S-adenosylmethionine (AdoMet), a key molecule in methylation reactions and polyamine biosynthesis, enhances axenic culture of the AIDS-associated opportunistic fungal pathogen Pneumocystis carinii. Here we report that AdoMet is absolutely required for continuous growth. Two transporters are
- Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove.
- J Biol Chem. 2000 May 19;275(20):15025-33. Unique Identifier : AIDSLINE MED/20270207
- Latham GJ; Forgacs E; Beard WA; Prasad R; Bebenek K; Kunkel TA; Wilson SH; Lloyd RS; Sealy Center for Molecular Science, University of Texas Medical; Branch, Galveston, Texas 77555-1071, USA.
- Biochemical and molecular modeling studies of human immunodeficiency virus type 1 reverse transcriptase (RT) have revealed that a structural element, the minor groove binding track (MGBT), is important for both replication frameshift fidelity and processivity. The MGBT interactions occur in the DNA minor groove from t
- In vitro studies on tRNA annealing and reverse transcription with mutant HIV-1 RNA templates.
- J Biol Chem. 2000 May 19;275(20):15474-81. Unique Identifier : AIDSLINE MED/20270264
- Beerens N; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, Amsterdam 1100 DE, The Netherlands.
- The human immunodeficiency virus type 1 (HIV-1) RNA genome encodes a semistable stem-loop structure, the U5-PBS hairpin, which occludes part of the tRNA primer binding site (PBS). In previous studies, we demonstrated that mutations that alter the stability of the U5-PBS hairpin inhibit virus replication. A reverse tra
- Detection of human cytomegalovirus pp67 late gene transcripts in cerebrospinal fluid of human immunodeficiency virus type 1-infected patients by nucleic acid sequence-based amplification.
- J Clin Microbiol. 2000 May;38(5):1920-5. Unique Identifier : AIDSLINE MED/20251007
- Zhang F; Tetali S; Wang XP; Kaplan MH; Cromme FV; Ginocchio CC; North Shore Long Island Jewish Health System Laboratories, Lake; Success, New York 11042, USA.
- This study examined the clinical correlation between the presence of human cytomegalovirus (HCMV) pp67 mRNA in cerebrospinal fluid (CSF) and active HCMV central nervous system (CNS) disease in patients with human immunodeficiency virus type 1 (HIV-1). In total, 76 CSF specimens col
- Development and evaluation of a molecular viability assay for Pneumocystis carinii.
- J Clin Microbiol. 2000 May;38(5):1947-52. Unique Identifier : AIDSLINE MED/20251011
- Maher N; Vermund S; Lasbury M; Lee C; Bartlett M; Unnasch TR; Division of Geographic Medicine, Department of Environmental; Health Sciences, University of Alabama at Birmingham, Birmingham,; Alabama, USA.
- Despite recent declines in incidence, Pneumocystis carinii pneumonia (PCP) remains the most commonly occurring opportunistic illness among persons with AIDS in the United States . While P. carinii DNA has been detected in patient respiratory specimens and in air samples collected from v
- Quantitation of cell-free and cell-associated Kaposi's sarcoma-associated herpesvirus DNA by real-time PCR.
- J Clin Microbiol. 2000 May;38(5):1992-5. Unique Identifier : AIDSLINE MED/20251023
- White IE; Campbell TB; Division of Infectious Diseases, Department of Medicine,; University of Colorado Health Sciences Center, Denver, Colorado,; USA.
- A real-time PCR assay for quantitation of Kaposi s sarcoma-associated herpes virus (KSHV or human herpesvirus 8) DNA was evaluated. The linear dynamic range was 10 to 10(5) copies of KSHV DNA (r(2) > 0.99). The accuracy of DNA purification and quantitation was less than +/-0.4 log(10) copies for samples that contained
- Isolation of an unusual Mycobacterium species from an AIDS patient with acute lymphadenitis.
- J Clin Microbiol. 2000 May;38(5):2018-20. Unique Identifier : AIDSLINE MED/20251031
- Bajolet O; Beguinot I; Brasme L; Jaussaud R; Ingrand D; Vincent V; Laboratoire de Bacteriologie, Virologie, Hygiene, Hopital; Robert Debre, 51092 Reims cedex, France. obajolet@chu-reims.fr
- A nonchromogenic Mycobacterium species was isolated from an AIDS patient with acute lymphadenitis. On the basis of the results of conventional tests, the strain appeared to be an atypical nonphotochromogenic Mycobacterium kansasii strain. Sequencing of the 16S rRNA gene revealed a unique nucleic acid sequence, suggest
- Th2-dependent airway eosinophilia is regulated by preproenkephalin.
- J Neuroimmunol. 2000 Jul 10;107(1):59-65. Unique Identifier : AIDSLINE MED/20270326
- Hook S; Prout M; Camberis M; Konig M; Zimmer A; Van Heeke G; Le Gros G; Malaghan Institute of Medical Research, Wellington School of; Medicine, P.O. Box 7060, Wellington, New Zealand.; shook@malaghan.org.nz
- We have used preproenkephalin (PPNK)-deficient mice to study the role of PPNK in the development of airway inflammation. Airway eosinophilia was established by either sensitization followed by airway challenge with OVA or by infection with Nippostrongylus brasiliensis. Both models induce a strong Th2 immune response,
- Interleukin-12 enhances clinical experimental autoimmune myasthenia gravis in susceptible but not resistant mice.
- Unique Identifier : AIDSLINE MED/20270328 P
- Sitaraman S; Metzger DW; Belloto RJ; Infante AJ; Wall KA
- Experimental autoimmune myositis in the lewis rat: lack of spontaneous T-cell apoptosis and therapeutic response to glucocorticosteroid application.
- J Neuroimmunol. 2000 Jul 10;107(1):83-7. Unique Identifier : AIDSLINE MED/20270329
- Schneider C; Matsumoto Y; Kohyama K; Toyka KV; Hartung HP; Gold R; Department of Neurology, Julius-Maximilians-Universitat; Wurzburg, Josef-Schneider-Strasse 11, 97080, Wurzburg, Germany.
- Recently, it has been shown that inflammatory T-cells in human idiopathic myositis only very rarely undergo spontaneous apoptosis. The animal model of experimental autoimmune myositis (EAM) in the Lewis rat was chosen to investigate whether similar findings hold true in rat muscle and if glucocorticosteroids act by in
- In activated mast cells, IL-1 up-regulates the production of several Th2-related cytokines including IL-9.
- J Immunol. 2000 Jun 1;164(11):5556-63. Unique Identifier : AIDSLINE MED/20281639
- Hultner L; Kolsch S; Stassen M; Kaspers U; Kremer JP; Mailhammer R; Moeller J; Broszeit H; Schmitt E; GSF-National Research Center for Environment and Health,; Institute of Experimental Hematology, Munchen, Germany.; hueltner@gsf.de
- Mast cells can play detrimental roles in the pathophysiology and mortality observed in anaphylaxis and other Th2-dominated allergic diseases. In contrast, these cells contribute to protective host defense mechanisms against parasitic worm infections. After IgE/Ag activation, mast cells can produce multiple cytokines t
- Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator.
- J Immunol. 2000 Jun 1;164(11):5575-82. Unique Identifier : AIDSLINE MED/20281641
- Shirota H; Sano K; Kikuchi T; Tamura G; Shirato K; First Department of Internal Medicine, Tohoku University School; of Medicine, Sendai, Japan.
- The characteristic features of bronchial asthma reflect the orchestrated activity of Th2 cells. Oligodeoxynucleotides containing CpG motifs (CpG) have recently been highlighted as an immunomodulator that biases toward a Th1-dominant phenotype. We have previously reported that intratracheal coadministration of CpG and
- A soluble lymphocyte activation gene-3 molecule used as a vaccine adjuvant elicits greater humoral and cellular immune responses to both particulate and soluble antigens.
- J Immunol. 2000 Jun 1;164(11):5583-9. Unique Identifier : AIDSLINE MED/20281642
- El Mir S; Triebel F; Laboratoire d'Immunologie des Tumeurs, Universite Paris-Sud,; Chatenay Malabry, France.
- The lymphocyte activation gene-3 (LAG-3) product is a MHC class II ligand that has been used in vivo to stimulate MHC class II+ APCs to increase tumor-specific immune responses. We investigated whether LAG-3 could also play an adjuvant role in vivo for the induction of humoral and CD4 or CD8 cell-mediated immune respo
- Constitutive expression of a chimeric receptor that delivers IL-2/IL-15 signals allows antigen-independent proliferation of CD8+CD44high but not other T cells.
- J Immunol. 2000 Jun 1;164(11):5659-67. Unique Identifier : AIDSLINE MED/20281651
- Gasser S; Corthesy P; Beerman F; MacDonald HR; Nabholz M; Lymphocyte Biology Unit, Swiss Institute for Experimental Cancer; Research, Epalinges, Switzerland.
- We have prepared transgenic mice whose T cells constitutively express a chimeric receptor combining extracellular human IL-4R and intracellular IL-2Rbeta segments. This receptor can transmit IL-2/IL-15-like signals in response to human, but not mouse, IL-4. We used these animals to explore to what extent functional IL
- Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.
- J Immunol. 2000 Jun 1;164(11):5675-82. Unique Identifier : AIDSLINE MED/20281653
- Kersh GJ; Engle DL; Williams CB; Allen PM; Department of Pathology and Center for Immunology, Washington; University School of Medicine, St. Louis, MO 63110, USA.
- Positive and negative selection of thymocytes is determined by the specificity of the TCR and signaling through its associated molecules. We have studied selection of thymocytes bearing a MHC class II-restricted TCR using fetal thymic organ culture. This system allows the addition of peptides to the already diverse pa
- CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo.
- J Immunol. 2000 Jun 1;164(11):5683-8. Unique Identifier : AIDSLINE MED/20281654
- Segal BM; Chang JT; Shevach EM; Laboratory of Immunology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.
- The mechanism of action of microbial adjuvants in promoting the differentiation of autoimmune effector cells remains to be elucidated. We demonstrate that CpG-containing oligodeoxynucleotides (ODN) can completely substitute for heat-killed mycobacteria in the priming of encephalitogenic myelin-reactive T cells in vivo
- IL-4 promotes the migration of circulating B cells to the spleen and increases splenic B cell survival.
- Unique Identifier : AIDSLINE MED/20281657
- Mori M; Morris SC; Orekhova T; Marinaro M; Giannini E; Finkelman FD
- We report that IL-4 causes a redistribution of B cells and modestly increases B cell life span. Intravenous injection of a long-acting formulation of IL-4 induces increases in both spleen cell number and the percentage of splenic B cells. These effects are observed within 1 day of IL-4 administration and plateau after
- Regulation of extrathymic T cell development and turnover by oncostatin M.
- J Immunol. 2000 Jun 1;164(11):5713-20. Unique Identifier : AIDSLINE MED/20281658
- Boileau C; Houde M; Dulude G; Clegg CH; Perreault C; Guy Bernier Research Center, Maisonneuve Rosemont Hospital,; Montreal, Quebec, Canada.
- Chronic exposure to oncostatin M (OM) has been shown to stimulate extrathymic T cell development. The present work shows that in OM transgenic mice, 1) massive extrathymic T cell development takes place exclusively the lymph nodes (LNs) and not in the bone marrow, liver, intestines, or spleen; and 2) LNs are the sole
- Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients.
- J Immunol. 2000 Jun 1;164(11):5739-45. Unique Identifier : AIDSLINE MED/20281661
- Ke B; Ritter T; Kato H; Zhai Y; Li J; Lehmann M; Busuttil RW; Volk HD; Kupiec-Weglinski JW; Dumont-University of California Los Angeles Transplant Center,; Department of Surgery, University of California Los Angeles; School of Medicine, Los Angeles, CA 90095, USA.
- We have previously shown that the tolerant state in allograft recipients can be maintained and perpetuated by an infectious T cell-dependent regulatory mechanism. Hence, 1) treatment of LEW rats with RIB-5/2, a CD4 nondepleting mAb, produces indefinite survival of LBNF1 cardiac allografts; 2) donor-specific toleranc
- Hoxa3 and pax1 transcription factors regulate the ability of fetal thymic epithelial cells to promote thymocyte development.
- J Immunol. 2000 Jun 1;164(11):5753-60. Unique Identifier : AIDSLINE MED/20281663
- Su DM; Manley NR; Institute of Molecular Medicine and Genetics and Department of; Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA.; nmanley@mail.mcg.edu
- Thymocyte maturation into T cells depends on interactions between thymocytes and thymic epithelial cells. In this study, we show that mutations in two transcription factors, Hoxa3 and Pax1, act synergistically to cause defective thymic epithelial cell development, resulting in thymic ectopia and hypoplasia. Hoxa3+/-Pa
- Revisiting tolerance induced by autoantigen in incomplete Freund's adjuvant.
- J Immunol. 2000 Jun 1;164(11):5771-81. Unique Identifier : AIDSLINE MED/20281665
- Heeger PS; Forsthuber T; Shive C; Biekert E; Genain C; Hofstetter HH; Karulin A; Lehmann PV; Department of Medicine, The Louis Stokes Cleveland Department of; Veterans Affairs Medical Center, Cleveland, OH 44106, USA.
- Injection of autoantigens in IFA has been one of the most effective ways of preventing experimental, T cell-mediated, autoimmune disease in mice. The mechanism that underlies this protection has, however, remained controversial, with clonal deletion, induction of suppressor cells or of type 2 immunity being implicated
- Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection.
- J Immunol. 2000 Jun 1;164(11):5890-3. Unique Identifier : AIDSLINE MED/20281680
- Monteforte GM; Takeda K; Rodriguez-Sosa M; Akira S; David JR; Satoskar AR; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, MA 02115, USA.
- IL-18 has been shown to play a critical role in the development of a Th1 response and immunity against intracellular pathogens. To determine the role of IL-18 in the development of protective immunity against Leishmania major, we have analyzed the course of cutaneous L. major in IL-18-deficient C57BL/6 mice (IL-18-/-)
- CD40 ligand (CD154) enhances the Th1 and antibody responses to respiratory syncytial virus in the BALB/c mouse.
- J Immunol. 2000 Jun 1;164(11):5913-21. Unique Identifier : AIDSLINE MED/20281683
- Tripp RA; Jones L; Anderson LJ; Brown MP; Division of Viral and Rickettsial Diseases, National Center of; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA. rgt3@cdc.gov
- CD40 ligand (CD40L) is a cell surface costimulatory molecule expressed mainly by activated T cells. CD40L is critically important for T-B cell and T cell-dendritic cell interactions. CD40L expression promotes Th1 cytokine responses to protein Ags and is responsible for Ig isotype switching in B cells. Respiratory sync
- Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes.
- J Immunol. 2000 Jun 1;164(11):5952-60. Unique Identifier : AIDSLINE MED/20281688
- Chizzolini C; Rezzonico R; De Luca C; Burger D; Dayer JM; Division of Immunology and Allergy (Hans Wilsdorf Laboratory),; Department of Internal Medicine, University Hospital, Geneva,; Switzerland. chizzoli@cmu.unige.ch
- Monocytes/macrophages are directly involved in tissue remodeling and tissue destruction through the release of matrix metalloproteinases (MMP). In the present study, we examined the effect mediated by contact of polarized Th cells with mononuclear phagocytes on the production of MMP-1, MMP-9, and their inhibitor. Plas
- Simian immunodeficiency virus (SIV)-specific CTL are present in large numbers in livers of SIV-infected rhesus monkeys.
- J Immunol. 2000 Jun 1;164(11):6015-9. Unique Identifier : AIDSLINE MED/20281695
- Schmitz JE; Kuroda MJ; Veazey RS; Seth A; Taylor WM; Nickerson CE; Lifton MA; Dailey PJ; Forman MA; Racz P; Tenner-Racz K; Letvin NL; Division of Viral Pathogenesis, Department of Medicine, Beth; Israel Deaconess Medical Center, Harvard Medical School, Boston,; MA 02215, USA. jschmitz@caregroup.harvard.edu
- The immunopathogenesis of AIDS-associated hepatitis was explored in the SIV/rhesus monkey model. The livers of SIV-infected monkeys showed a mild hepatitis, with a predominantly CD8+ T lymphocyte infiltration in the periportal fields and sinusoids. These liver-associated CD8+ T cells were comprised of a high percentag
- Intraallograft chemokine RNA and protein during rejection of MHC-matched/multiple minor histocompatibility-disparate skin grafts.
- J Immunol. 2000 Jun 1;164(11):6027-33. Unique Identifier : AIDSLINE MED/20281697
- Watarai Y; Koga S; Paolone DR; Engeman TM; Tannenbaum C; Hamilton TA; Fairchild RL; Departments of Urology and Immunology, Cleveland Clinic; Foundation, Cleveland, OH 44195, USA.
- Chemokines direct leukocyte recruitment into sites of tissue inflammation and may facilitate recruitment of leukocytes into allografts following transplantation. Although the expression of chemokines during rejection of MHC-disparate allografts has been examined, chemokine expression in MHC-matched/multiple minor hist
- IL-18 prevents the development of chronic graft-versus-host disease in mice.
- J Immunol. 2000 Jun 1;164(11):6067-74. Unique Identifier : AIDSLINE MED/20281702
- Okamoto I; Kohno K; Tanimoto T; Iwaki K; Ishihara T; Akamatsu S; Ikegami H; Kurimoto M; Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.,; Okayama, Japan. kohnok@hayashibara.co.jp
- The development of chronic graft-versus-host disease (GVHD), which is induced by the transfer of DBA/2 spleen cells into (C57BL/6 x DBA/2)F1 (BDF1) mice, is closely related to diminished donor anti-host CTL activity and host B cell hyperactivation. Therefore, an approach which activates donor CD8+ T cells or suppresse
- A titrated morphine analgesic regimen comparing substance users and non-users with AIDS-related pain.
- J Pain Symptom Manage. 2000 Apr;19(4):265-73. Unique Identifier : AIDSLINE MED/20261703
- Kaplan R; Slywka J; Slagle S; Ries K; Department of Anesthesiology, Montefiore Medical Center, Bronx,; NY, USA.
- To compare morphine dosage and effectiveness in AIDS patients with/without prior substance use and pain, a prospective, open-label case series lasting 3-18 days was conducted in both outpatients and inpatients at major pain service teaching programs. Forty-four patients, 13 with prior drug use history, who had pain as
- A pilot survey of aberrant drug-taking attitudes and behaviors in samples of cancer and AIDS patients.
- J Pain Symptom Manage. 2000 Apr;19(4):274-86. Unique Identifier : AIDSLINE MED/20261704
- Passik SD; Kirsh KL; McDonald MV; Ahn S; Russak SM; Martin L; Rosenfeld B; Breitbart WS; Portenoy RK; Oncology Symptom Control Research, Community Cancer Center, Inc.,; Indianapolis, IN 46202, USA.
- The clinical assessment of drug-taking behaviors in medically ill patients with pain is complex and may be hindered by the lack of empirically derived information about such behaviors in particularly medically ill populations. To investigate issues surrounding the assessment of these behaviors, we piloted a questionna
- [A two-year follow-up of zidovudine plus lamivudine combined with indinavir in antivival naive HIV-infected patients]
- Kansenshogaku Zasshi. 2000 Feb;74(2):128-33. Unique Identifier : AIDSLINE MED/20205176
- Aizawa S; Sakai-Hachiya A; Ida S; Tachikawa N; Kikuchi Y; Aoki M; Yasuoka A; Oka S; AIDS Clinical Center, International Medical Center of Japan.
- Efficacy of a 3-drug combination (Zidovudine ( AZT ) + Lamivudine ( 3TC ) +
- Antileprosy protective vaccination of rhesus monkeys with BCG or BCG plus heat-killed Mycobacterium leprae: immunologic observations.
- Int J Lepr Other Mycobact Dis. 2000 Mar;68(1):27-39. Unique Identifier : AIDSLINE MED/20293977
- Gormus BJ; Baskin GB; Xu K; Ratterree MS; Martin LN; Mack PA; Bohm RP Jr; Meyers WM; Walsh GP; Department of Microbiology, Tulane Regional Primate Research; Center, Covington, LA 70433, USA. gormus@tpc.tulane.edu
- Groups of rhesus monkeys were vaccinated and boosted with Mycobacterium bovis bacillus Calmette Guerin (BCG) or BCG plus low-dose (LD) or high-dose (HD) heat-killed M. leprae (HKML), or were unvaccinated. Prior to and following vaccination-boosting and subsequent M. leprae (ML) challenge, these and unvaccinated, uncha
- HIV seroprevalence in leprosy patients [letter]
- Int J Lepr Other Mycobact Dis. 2000 Mar;68(1):67-9. Unique Identifier : AIDSLINE MED/20293983
- Hussain T; Kulshreshtha K; Ghei SK; Natarajan M; Katoch K; Sengupta U
- [Effects of psidium components on cytokine productions in helper T cells and type-I allergy]
- Yakugaku Zasshi. 2000 Apr;120(4):408-12. Unique Identifier : AIDSLINE MED/20236077
- Kosuge T; Shishikura H; Kitanaka S; Toyoshima S; Department of Biochemistry, Faculty of Pharmaceutical Science,; Hoshi University, Tokyo, Japan.
- Psidium genus Myrtaceae (Psidium) is known to be a chinese medicine with an anti-allergy effect. In the present study, to identify active components in Psidium and investigate mechanisms of its anti-allergy effect, effects of several components isolated from Psidium on cytokine production in helper T cell subtypes, Th
- Bucillamine suppresses human Th1 cell development by a hydrogen peroxide-independent mechanism.
- J Rheumatol. 2000 Apr;27(4):851-8. Unique Identifier : AIDSLINE MED/20242900
- Morinobu A; Wang Z; Kumagai S; Department of Clinical and Laboratory Medicine, School of; Medicine, Kobe University, Japan. morinobu@med.kobe-u.ac.jp
- OBJECTIVE: To clarify the effect of bucillamine, an antirheumatic drug related to D-penicillamine, on the development of human Th1 and Th2 cells in vitro. METHODS: Peripheral blood mononuclear cells (PBMC) or purified CD4+ T cells were subjected to the priming culture in which cells were stimulated with anti-CD3 and a
- Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells.
- J Rheumatol. 2000 Apr;27(4):874-81. Unique Identifier : AIDSLINE MED/20242903
- Yin W; Hasunuma T; Kobata T; Sumida T; Nishioka K; Rheumatology, Immunology and Genetics Program, Institute of; Medical Science, St. Marianna University School of Medicine,; Kawasaki, Japan.
- OBJECTIVE: To investigate the pathogenic role of macrophage lineage (CD68+) cells in synovial proliferation in patients with human T cell leukemia virus I (HTLV-I) associated arthropathy (HAAP). METHODS: Synovial tissues obtained from 3 patients with HAAP and 3 patients with osteoarthritis (OA) were examined for the e
- [Epstein-Barr virus and malignant lymphoma]
- Nippon Rinsho. 2000 Mar;58(3):548-53. Unique Identifier : AIDSLINE MED/20205297
- Tomita Y; Aozasa K; Department of Pathology, Osaka University Medical School.
- Association between Epstein-Barr virus and malignant lymphomas such as Burkitt s lymphoma, Hodgkin s disease(HD), nasal T/NK cell lymphoma(NTL), immunodefficiency-associated lymphoma, and pyothorax associated lymphoma (PAL) has been suggested. Among these, HD, SNL, PAL are relatively common in
- [Human herpesvirus 6(HHV-6) and HHV-8 in malignant lymphoma]
- Nippon Rinsho. 2000 Mar;58(3):560-6. Unique Identifier : AIDSLINE MED/20205299
- Daibata M; Third Department of Medicine, Kochi Medical School.
- Over the past 14 years three new human herpesviruses(HHV-6, -7 and -8) have been recognized and implicated as etiological agents of several human diseases. HHV-6 has been cited as a possible cause or as a modulating element of certain human lymphoproliferative disorders, particularly malignant lymphomas including Hodg
- [Clinicopathological characteristics of Burkitt lymphoma]
- Nippon Rinsho. 2000 Mar;58(3):635-8. Unique Identifier : AIDSLINE MED/20205310
- Ohnishi K; Department of Medicine III, Hamamatsu University School of; Medicine.
- In the new WHO classification, the category of Burkitt lymphoma includes classic Burkitt lymphoma and a variant-Burkitt-like-lymphoma. In addition, three subcategories--endemic, non-endemic, and immunodeficiency-associated--were proposed to reflect the major clinical and genetic subtypes of this disease. Endemic Burki
- [Clinico-pathological aspects of adult T-cell leukemia/lymphoma(ATL)]
- Nippon Rinsho. 2000 Mar;58(3):655-9. Unique Identifier : AIDSLINE MED/20205314
- Fujimoto T; Yamada Y; Department of Hematology, Atomic Bomb Disease Institute, Nagasaki; University School of Medicine.
- Adult T-cell leukemia/lymphoma(ATL) was first discovered and reported in Japan , where it has a high incidence in the southwestern region of the country. The retrovirus human T-cell leukemia virus type I(HTLV-I) is considered to be related to its etiology. ATL shows divers clinical f
- [Clinicopathological differential diagnosis of mycosis fungoides/Sezary syndrome from the cutaneous type of adult T-cell leukemia/lymphoma]
- Nippon Rinsho. 2000 Mar;58(3):660-4. Unique Identifier : AIDSLINE MED/20205315
- Johno M; Ono T; Department of Dermatology, Kumamoto University School of; Medicine.
- Mycosis fungoides/Sezary syndrome(MF/SS) is considered as a distinct clinical entity in the latest classifications, including the revised European-American classification of lymphoid neoplasm(REAL), and the ones by the WHO and the European Organization for Research and Treatment of Cancer(EORTC). In
- [AIDS-related malignant lymphoma]
- Nippon Rinsho. 2000 Mar;58(3):669-72. Unique Identifier : AIDSLINE MED/20205317
- Nakamura T; Division of Infectious Diseases and Applied Immunology,; University of Tokyo.
- Patients with HIV-1 infection have high risk for malignant lymphoma(AIDS lymphoma). In Japanese patients, more than 90% of AIDS lymphoma are related to EBV. All 22 cases which we have experienced are non-Hodgkin s lymphoma and their histological classification is either diffuse lar
- [Search for an endogenous ligand of the orphan G protein-coupled receptor--discovery of apelin, a novel biologically active peptide]
- Unique Identifier : AIDSLINE MED/20205327
- Tatemoto K
- In the search for an endogenous ligand of the human orphan receptor APJ, we have isolated from bovine stomach extracts a novel 36-amino acid peptide, designated apelin. The APJ receptor is one of the G protein-coupled orphan receptors, many of which
- [A case of collapsing variant of FSGS]
- Nippon Jinzo Gakkai Shi. 2000 Feb;42(2):47-52. Unique Identifier : AIDSLINE MED/20234070
- Nagai C; Yokota S; Kido Y; Katayama N; Nishiya M; Koizumi H; Namiki M; Nakamoto Y; Department of Internal Medicine, Kenseikai Tachikawa Sougo; Hospital, Japan.
- We report a case of collapsing variant of FSGS. An 82-year-old man without HIV-1 infection or a history of intravenous drug abuse was admitted to our hospital with the chief complaints of acute onset of generalized edema and loss of appetite. Laboratory findings were consistent with nephrotic syndrome. He developed ac
- Database and informatics support for QUERI: current systems and future needs. Quality Enhancement Research Initiative.
- Med Care. 2000 Jun;38(6 Suppl 1):I114-28. Unique Identifier : AIDSLINE MED/20300262
- Hynes DM; Cowper D; Kerr M; Kubal J; Murphy PA; Veterans Affairs Information Resource Center, a Department of; Veterans Affairs Health Service Research and Development Service; Resource Center at the Edwards Hines, Jr, Veterans Affairs; Hospital, Illinois 60141-5000, USA.; hynes@research.hines.med.va.gov
- OBJECTIVES: Our primary objective is to provide an overview of database and informatics support for the Department of Veterans Affairs (VA) Quality Enhancement Research Initiative (QUERI). METHODS: We discuss the role of information technology resources in the QUERI process. We also review current VA information syste
- Quality Enhancement Research Initiative for human immunodeficiency virus/acquired immunodeficiency syndrome: framework and plan. HIV-QUERI Executive Committee.
- Med Care. 2000 Jun;38(6 Suppl 1):I60-9. Unique Identifier : AIDSLINE MED/20300257
- Bozzette SA; Phillips B; Asch S; Gifford AL; Lenert L; Menke T; Oritz E; Owens D; Deyton L; Veterans Affairs San Diego Healthcare System and the University; of California San Diego, USA. sbozzette@ucsd.edu
- The Veterans Health Administration (VHA) sees approximately equal to 17,000 human immunodeficiency virus (HIV)-infected patients each year, which makes it the largest provider of HIV care in the United States . HIV causes chronic progressive disease that leads to early death. Newer comb
- Leishmania and HIV co-infection [news]
- Lepr Rev. 2000 Mar;71(1):104-5. Unique Identifier : AIDSLINE MED/20280636
- Late diagnosis of three cases of transfusion-acquired HIV-1 infection [letter]
- Med J Aust. 2000 Apr 3;172(7):349. Unique Identifier : AIDSLINE MED/20303345
- Learmont JC; Raynes-Greenow CH; Branley JM; Frankum BS; Maddocks S; Iredell JR
- A novel subtype of type 1 diabetes mellitus [letter]
- N Engl J Med. 2000 Jun 15;342(24):1835-7. Unique Identifier : AIDSLINE MED/20294802
- Tanaka S; Kobayashi T; Momotsu T
- Editor defends publishing key AZT paper [news]
- Nature. 2000 May 11;405(6783):105. Unique Identifier : AIDSLINE MED/20279256
- Loder N
- South Africa turns to research in the hope of settling AIDS policy [news]
- Nature. 2000 May 11;405(6783):105-6. Unique Identifier : AIDSLINE MED/20279255
- Cherry M
- Bacterial AIDS vaccine ready for testing [news]
- Nature. 2000 May 25;405(6785):386. Unique Identifier : AIDSLINE MED/20296319
- Smaglik P
- Vaccination against coccidiosis: host strain-dependent evocation of protective and suppressive subsets of murine lymphocytes.
- Parasite Immunol. 2000 Apr;22(4):161-72. Unique Identifier : AIDSLINE MED/20223695
- Rose ME; Hesketh P; Grencis RK; Bancroft AJ; Division of Immunology and Pathology, Institute for Animal; Health, Compton, Newbury, Berkshire RG20 7NN, UK.
- BALB/c mice are normally more resistant than C57BL/6 (B6) mice to infection with Eimeria vermiformis, but these phenotypes can be reversed by oral or parenteral vaccination with a crude antigen prepared from the parasite. Treatment of mice with antibodies specific for CD4+ or CD8+ T cells showed that the increased sus
- Cellular responses to Loa loa experimental infection in mandrills (Mandrillus sphinx) vaccinated with irradiated infective larvae.
- Parasite Immunol. 2000 Apr;22(4):173-83. Unique Identifier : AIDSLINE MED/20223696
- Ungeheuer M; Elissa N; Morelli A; Georges AJ; Deloron P; Debre P; Bain O; Millet P; Centre International de Recherches Medicales de Franceville,; Franceville, Gabon.
- In order to shed light on the mechanisms of antifilarial protective immunity, we investigated the course of experimental loaiosis after vaccination in a nonhuman primate host, Mandrillus sphinx. Six vaccinated (V) mandrills received 50 irradiated L3 while six nonvaccinated (NV) received saline solution on days 60, -30
- Genotypic characterization of human immunodeficiency virus type 1 isolated from vertically infected children with antiretroviral therapy experience.
- Pediatr Infect Dis J. 2000 Apr;19(4):363-4. Unique Identifier : AIDSLINE MED/20243129
- Johann-Liang R; Lee SE; Fernandez A; Cervia J; Noel GJ; The Children's Clinical Research Center and The Program for; Children with AIDS, New York Presbytarian Hospital-Weill Medical; College at Cornell University, New York, USA.; rsj2001@mail.med.cornell.edu
- Surface plasmon resonance kinetic studies of the HIV TAR RNA kissing hairpin complex and its stabilization by 2-thiouridine modification.
- Nucleic Acids Res. 2000 May 1;28(9):1935-40. Unique Identifier : AIDSLINE MED/20221590
- Nair TM; Myszka DG; Davis DR; Department of Medicinal Chemistry, University of Utah, Salt Lake; City, UT 84112, USA.
- Surface plasmon resonance (BIACORE) was used to determine the kinetic values for formation of the HIV TAR-TAR* ( kissing hairpin ) RNA complex. The TAR component was also synthesized with the modified nucleoside 2-thiouridine at position 7 in the loop and the kinetics and equilibrium dissociation constants compared wi
- Interactions of peptides with liposomes: pore formation and fusion.
- Prog Lipid Res. 2000 Mar;39(2):181-206. Unique Identifier : AIDSLINE MED/20240145
- Nir S; Nieva JL; Seagram Center for Soil and Water Sciences, Faculty of; Agricultural, Food and Environmental Quality Sciences, Rehovot,; Israel. nirl@agri.huji.ac.il
- Leakage from liposomes induced by several peptides is reviewed and a pore model is described. According to this model peptide molecules become incorporated into the vesicle bilayer and aggregate reversibly or irreversibly within the surface. When a peptide aggregate reaches a critical size, peptide translocation can o
- When children tell their friends they have AIDS: possible consequences for psychological well-being and disease progression.
- Unique Identifier : AIDSLINE MED/20233358
- Sherman BF; Bonanno GA; Wiener LS; Battles HB
- OBJECTIVE: Past research has demonstrated that self-disclosure of traumatic or secretive information produces observable health benefits. Self-disclosure has also been linked, albeit less consistently, to improved psychological health. The present study examined the physiological and psychological consequences of chil
- [Tuberculosis associated with the human immunodeficiency virus]
- Rev Med Brux. 2000 Apr;21(2):75-83. Unique Identifier : AIDSLINE MED/20288408
- Gerard M; Clinique des Maladies infectieuses, C.H.U. Saint Pierre, U.L.B.
- The HIV pandemic is one of the factors that have contributed to the the worldwide increase in tuberculosis cases especially in subsaharian Africa. The copathogenicity between M. tuberculosis and HIV is best illustrated by the high susceptibility of the HIV-infected persons for reactivation of a remote tuberculous infe
- [Neurological complications of HIV infection. Review: new diagnostic, therapeutic and prognostic aspects]
- Schweiz Med Wochenschr. 2000 Apr 1;130(13):457-70. Unique Identifier : AIDSLINE MED/20272521
- Radziwill AJ; Kappos L; Battegay M; Steck AJ; Neurologische Universitatsklinik und Poliklinik, Kantonsspital; Basel. aradziwill@uhbs.ch
- About one third of patients with HIV infection show neurological complications with considerable morbidity and high mortality. This is an actualized review of the most important neurological manifestations resulting from primary HIV infection, from secondary opportunistic infections, or as complications of antiretrovi
- Ethnicity and sexual behavior in Ghana.
- Soc Biol. 1999 Spring-Summer;46(1-2):17-32. Unique Identifier : AIDSLINE MED/20301316
- Addai I; Social Science Department, Lansing Community College, Michigan; 48901, USA.
- Using data from the 1993 Ghana Demographic and Health Survey, this study explores the relationship between ethnicity and sexual behavior: having sex before age 17 and premarital sexual experience. All ethnic groups show substantial sexual experience before age 17 and premarital sexug
- HIV/AIDS social and behavioural research: past advances and thoughts about the future [editorial]
- Soc Sci Med. 2000 Jun;50(11):1519-32. Unique Identifier : AIDSLINE MED/20254977
- Moatti JP; Souteyrand Y
- This paper is an introduction to the various contributions in this special issue of Social Science & Medicine which are an attempt to synthesise the main debates of the 2nd European Conference on Social and Behavioural Research on AIDS held in Paris, in January 1998. The paper discusses how the recent advent of hig
- Research on HIV sexual risk: social relations-based approach in a cross-cultural perspective.
- Soc Sci Med. 2000 Jun;50(11):1533-46. Unique Identifier : AIDSLINE MED/20254978
- Bajos N; Marquet J; Hopital de Bicetre, Le Kremlin Bicetre, France.; bajos@vjf.inserm.fr
- In opposition to individual-oriented approaches to sexual risk taking, new theoretical approaches have emerged that strive to encompass all of the social relations--that is to say, the connections that structure the components of relations between groups and go beyond simple adaptations to a given interaction--that pr
- Social change and HIV in the former USSR: the making of a new epidemic.
- Soc Sci Med. 2000 Jun;50(11):1547-56. Unique Identifier : AIDSLINE MED/20254979
- Atlani L; Carael M; Brunet JB; Frasca T; Chaika N; National Centre for Scientific Research, Centre National pour la; Recherche Scientifique, Laboratoire d'Ethnologie et de Sociologie; Comparative UMR 7535 Paris X-Nanterre University, France.; 101477.2611@compuserve.com
- This paper describes the development of the recent HIV epidemic in countries of the former Soviet Union. It explores the socio-political and economic roots of an injection-drug-driven HIV epidemic associated with a drug culture that facilitates HIV transmission. This review, based on many unpublished reports, studies
- Revisiting the concept of 'vulnerability'.
- Soc Sci Med. 2000 Jun;50(11):1557-70. Unique Identifier : AIDSLINE MED/20254980
- Delor F; Hubert M; Centre d'etudes Sociologiques, Facultes universitaires; Saint-Louis, Brussels, Belgium. delor@fusl.ac.be
- The terms vulnerable and vulnerability are used more and more frequently in the areas of both social science research into and prevention of HIV/AIDS, but certain difficulties arise when it comes to applying this concept to actual situations at the heart of which individuals or groups are more exposed to HIV. The
- HIV-positive people, risk and sexual behaviour.
- Soc Sci Med. 2000 Jun;50(11):1571-88. Unique Identifier : AIDSLINE MED/20254981
- Schiltz MA; Sandfort TG; Ingenieur de Recherche, CAMS-CERMES-CNRS-EHESS, Paris, France.; schiltz@msh-paris.fr
- For a long time, the sexual behaviour of HIV-infected persons did not receive any serious attention for a variety of reasons. Initially, diagnosis of HIV-infection appeared to imply a death sentence. In this context, the sex life of those infected seemed a secondary issue making prevention focused on sexual behaviour
- Everyday life with AIDS/HIV: surveys in the social sciences.
- Soc Sci Med. 2000 Jun;50(11):1589-98. Unique Identifier : AIDSLINE MED/20254982
- Pierret J; Centre de Recherche Medecine, Sciences, Sante et Societe,; CNRS/INSERM/EHESS, Paris, France. pierret@ext.jussieu.fr
- Research on persons infected with HIV is critically assessed by using the notions developed in the sociology of illness. Has this research stimulated new questions or led to reformulations in research paradigms? Methodological problems related to data collection are pointed out, namely: the recruitment of HIV-positive
- Adherence to HIV combination therapy.
- Soc Sci Med. 2000 Jun;50(11):1599-605. Unique Identifier : AIDSLINE MED/20254983
- Chesney MA; Morin M; Sherr L; School of Medicine, University of California, San Francisco,; 94105, USA. mchesney@psg.ucsf.edu
- The emergence of drug-resistant strains of HIV virus and treatment failure can result from non-adherence to antiretroviral therapy. While non-adherence to therapy is not a new issue or specific to HIV/AIDS, it has received renewed attention because of the complicated combination treatment regimens being prescribed. Th
- The normalization of AIDS in Western European countries.
- Soc Sci Med. 2000 Jun;50(11):1607-29. Unique Identifier : AIDSLINE MED/20254984
- Rosenbrock R; Dubois-Arber F; Moers M; Pinell P; Schaeffer D; Setbon M; Social Science Research Center, Wissenschaftszentrum Berlin fur; Sozialforschung (WZB), Research Unit Public Health Policy,; Germany. rosenbrock@medea.wz-berlin.de
- The occurrence of AIDS led in every Western European country to exceptional innovations in prevention, patient care, health policy and questions of civil rights. This exception can be explained above all by the fact that not only was a health catastrophe feared but also civilizational harm in the field of civil rights
- [Recently discovered herpes viruses explain the etiology of well-known diseases]
- Tidsskr Nor Laegeforen. 1999 Dec 10;119(30):4463-6. Unique Identifier : AIDSLINE MED/20286801
- Bergstrom T; Virologiska laboratoriet Sahlgrenska Universitetssjukhuset,; Goteborg. tomas.bergstrom@microbio.gu.se
- Three new members of the family of human herpesviruses (HHVs) have been identified in less than a decade, HHV 6 7 and 8. HHV-6 and HHV-7, both infecting T-lymphocytes and phylogenetically related to cytomegalovirus , were identified as causative agents of exanthema subitum. In addit
- [Tuberculosis of the hand]
- Tidsskr Nor Laegeforen. 2000 Feb 10;120(4):445-6. Unique Identifier : AIDSLINE MED/20293844
- Kali L; Lund F; Ortopaedkirurgisk afdeling Roskilde Amtssygehuset Koge.
- Since 1985 there has been an increase in the incidence of skeletal tuberculosis in Denmark . This increase is attributed to a high incidence of tuberculosis among HIV-positive patients, elderly people and the increasing number of imm
- Nivalenol inhibits total and antigen-specific IgE production in mice.
- Toxicol Appl Pharmacol. 2000 May 15;165(1):94-8. Unique Identifier : AIDSLINE MED/20276103
- Choi CY; Nakajima-Adachi H; Kaminogawa S; Sugita-Konishi Y; Department of Biomedical Food Research, National Institute of; Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640,; Japan.
- Nivalenol (NIV) has been reported to induce hyperproduction of IgA, which is regulated by T-helper 2 cells (Th2); however, whether IgE production, which is under the regulation of Th2 cells, is induced by this compound remains largely unknown. We examined the effect of NIV on antigen-specific IgE production using oval
- The popliteal lymph node response to streptozotocin is under type 1, MHC class-I restricted, CD8(+) T-cell control.
- Toxicology. 2000 Apr 20;146(1):73-82. Unique Identifier : AIDSLINE MED/20237975
- Choquet-Kastylevsky G; Tedone R; Ducluzeau MT; Kehren J; Nicolas JF; Descotes J; INSERM U503, Toxicologie Medicale et Medecine de; l'Environnement, Faculte de Medecine Lyon-RTH Laennec, 69372,; Lyon, France. choquet@laennec.univ-lyonl.fr
- The popliteal lymph node (PLN) assay has been proposed to predict the autoimmunogenic potential of xenobiotics. A better understanding of the processes involved in PLN responses is needed to establish the value of this assay for preclinical safety evaluation. In order to determine whether PLN responses involve CD4(+
- Prevalence and pathogenicity of retroviruses in wildcats in France.
- Vet Rec. 2000 Mar 11;146(11):317-9. Unique Identifier : AIDSLINE MED/20227183
- Fromont E; Sager A; Leger F; Bourguemestre F; Jouquelet E; Stahl P; Pontier D; Artois M; UMR CNRS 5558, Universite Lyon I, Villeurbanne, France.
- Feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) are frequently encountered in domestic cats (Felis catus) and in wild felids, but only FeLV has been previously identified in wildcats (Fellis silvestris). Thirty-eight wildcats, either captured alive or found dead, were sampled in eastern and centr
- Large deletion of the X-linked lymphoproliferative disease gene detected by fluorescence in situ hybridization.
- Am J Hematol. 2000 Jun;64(2):128-32. Unique Identifier : AIDSLINE MED/20275437
- Honda K; Kanegane H; Eguchi M; Kimura H; Morishima T; Masaki K; Tosato G; Miyawaki T; Ishii E; Division of Pediatrics, Hamanomachi Hospital, Fukuoka, Japan.
- The X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency characterized by an abnormal responses to infection with Epstein-Barr virus (EBV), resulting in fatal infectious mononucleosis, hypogammaglobulinemia, virus-associated hemophagocytic syndrome, and malignant lymphoma. Mutations in the gene
- Acute brachial artery thrombosis as the initial manifestation of human immunodeficiency virus infection.
- Am J Hematol. 2000 Jun;64(2):137-9. Unique Identifier : AIDSLINE MED/20275439
- Witz M; Lehmann J; Korzets Z; Unit of Vascular Surgery, Meir Hospital, Kfar-Saba, and the; Sackler School of Medicine, University of Tel-Aviv, Tel-Aviv,; Israel.
- Thrombosis of upper extremity arteries is most commonly due to atherosclerosis of the proximal subclavian artery, trauma, or catheter-related injury. In the absence of an identifiable cause, a search for a hypercoagulable state is indicated. Hematologic manifestations of human immunodeficiency virus (HIV) infection an
- Thalidomide: current and potential clinical applications.
- Am J Med. 2000 Apr 15;108(6):487-95. Unique Identifier : AIDSLINE MED/20245091
- Calabrese L; Fleischer AB; Department of Rheumatic and Immunologic Disease, The Cleveland; Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA.
- More than three decades after its withdrawal from the world marketplace, thalidomide is attracting growing interest because of its reported immunomodulatory and anti-inflammatory properties. Current evidence indicates that thalidomide reduces the activity of the inflammatory cytokine tumor necrosis factor (TNF)-alpha
- Cryptococcal infection associated with fludarabine therapy [letter]
- Am J Med. 2000 Apr 15;108(6):523-4. Unique Identifier : AIDSLINE MED/20315487
- Chim CS; Liang R; Wong SS; Yuen KY
- Short-term treatment with indinavir fails to reduce the glucose requirement in a patient with malignant insulinoma [letter]
- Am J Med. 2000 Apr 15;108(6):524. Unique Identifier : AIDSLINE MED/20315488
- Schutt M; Aries SP; Rosenfeldt M; Peters A; Klein HH
- The occupational risk to dental anesthesiologists of acquiring 3 bloodborne pathogens.
- Anesth Prog. 1999 Spring;46(2):63-70. Unique Identifier : AIDSLINE MED/20312034
- Suljak JP; Leake JL; Haas DA; Faculty of Dentistry, University of Toronto, Ontario, Canada.
- OBJECTIVE: To estimate the occupational risk to dental anesthesiologists of contracting 3 bloodborne pathogens: hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV). METHODS: Through an anonymously returned, mailed questionnaire, dental anesthesiologists in Cana
- Antiviral activity of ganciclovir elaidic acid ester against herpesviruses.
- Antiviral Res. 2000 Mar;45(3):157-67. Unique Identifier : AIDSLINE MED/20235168
- Andrei G; Snoeck R; Neyts J; Sandvold ML; Myhren F; De Clercq E; Rega Institute for Medical Research, Minderbroedersstraat 10,; K.U. Leuven, B-3000, Leuven, Belgium.; graciela.andrei@rega.kuleuven.ac.be
- A fatty acid derivative of ganciclovir (GCV), elaidic acid ganciclovir (E-GCV), has been evaluated for its inhibitory activity against laboratory and clinical strains of herpes simplex type 1 (HSV-1) and type 2 (HSV-2), varicella-zoster virus (VZV) and human cytomegalovirus (HCMV)
- Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides.
- Antiviral Res. 2000 Mar;45(3):169-83. Unique Identifier : AIDSLINE MED/20235169
- Pierra C; Imbach JL; De Clercq E; Balzarini J; Van Aerschot A; Herdewijn P; Faraj A; Loi AG; Sommadossi JP; Gosselin G; Laboratoire de Chimie Organique Biomoleculaire de Synthese, UMR; CNRS 5625, Case Courrier 008, Universite Montpellier II, Place; Eugene Bataillon, 34095, Montpellier, France.
- The synthesis and in vitro anti human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activities of some unnatural beta-L-nucleoside enantiomers related to the anti-HIV compound 2 , 3 -dideoxy-3 -fluoro-5-chlorouridine (beta-D-3 Fdd5ClU) are reported. In contrast to beta-D-3 Fdd5ClU, beta-L-3 Fdd5ClU and
- The patient's response to medical futility [editorial; comment]
- Arch Intern Med. 2000 Jun 12;160(11):1565-6. Unique Identifier : AIDSLINE MED/20303860
- McGee DC; Weinacker AB; Raffin TA
- The attitudes of patients with advanced AIDS toward use of the medical futility rationale in decisions to forego mechanical ventilation [see comments]
- Arch Intern Med. 2000 Jun 12;160(11):1597-601. Unique Identifier : AIDSLINE MED/20303865
- Curtis JR; Patrick DL; Caldwell ES; Collier AC; Department of Medicine, University of Washington, Seattle, USA.; jrc@u.washington.edu
- BACKGROUND: The medical futility rationale asserts that physicians need not offer their patients therapies that have zero or close to zero probability of success. The rationale is controversial, but it is used in practice. OBJECTIVE: To examine the attitudes of patients with advanced acquired immunodeficiency syndrome
- Physical and sexual abuse in women infected with the human immunodeficiency virus: increased illness and health care utilization.
- Arch Intern Med. 2000 Jun 12;160(11):1659-64. Unique Identifier : AIDSLINE MED/20303872
- Liebschutz JM; Feinman G; Sullivan L; Stein M; Samet J; Clinical AIDS Program, Department of Medicine, Boston Medical; Center, Boston University School of Medicine, Mass 02118, USA.; jliebs@bu.edu
- BACKGROUND: A history of physical or sexual abuse is associated with increased health care utilization and possibly an increase in illness based largely on self-reported data. OBJECTIVE: To examine whether victimization experience is associated with increases in documented medical disease and health care utilization a
- Why don't patients and physicians talk about end-of-life care? Barriers to communication for patients with acquired immunodeficiency syndrome and their primary care clinicians [see comments]
- Arch Intern Med. 2000 Jun 12;160(11):1690-6. Unique Identifier : AIDSLINE MED/20303876
- Curtis JR; Patrick DL; Caldwell ES; Collier AC; Department of Medicine, University of Washington, Seattle; 98104-2499, USA. jrc@u.washington.edu
- BACKGROUND: Patients with chronic and terminal disease frequently do not talk to their physicians about end-of-life care. Interventions to improve this communication have generally been unsuccessful, suggesting that important barriers to this communication must exist. OBJECTIVES: To determine the barriers to and facil
- Valacyclovir hydrochloride therapy and thrombotic thrombocytopenic purpura in an HIV-infected patient [letter]
- Arch Intern Med. 2000 Jun 12;160(11):1705-6. Unique Identifier : AIDSLINE MED/20303887
- Rivaud E; Massiani MA; Vincent F; Azoulay E; Coudrec LJ
- [Cardiac beriberi]
- Arch Mal Coeur Vaiss. 2000 Apr;93(4):371-9. Unique Identifier : AIDSLINE MED/20276806
- Blanc P; Boussuges A; Service de reanimation polyvalente, CHD Felix-Guyon,; Saint-Denis, La Reunion.
- Interest has recently risen regarding thiamine deficiency (beriberi). In industrial countries, not only alcoholics, but also deprived people with malnutrition, elderly patients and patients with AIDS are at risk of thiamine deficiency. Moreover, long-term furosemide use may be associated with thiamine deficiency throu
- Child resiliency in inner-city families affected by HIV: the role of family variables.
- Behav Res Ther. 2000 May;38(5):471-86. Unique Identifier : AIDSLINE MED/20276904
- Dutra R; Forehand R; Armistead L; Brody G; Morse E; Morse PS; Clark L; University of Georgia, Athens 30602, USA.
- This study examined the role of family variables in child resiliency within a sample of African-American, inner-city children whose mothers are HIV-infected. Variables from three dimensions of the family were included: family structural variables, maternal variables, and mother-child (parenting) variables. The partici
- A retroviral vector capable of targeted gene transfer into cells expressing HIV envelope glycoprotein.
- Biochem Biophys Res Commun. 2000 May 19;271(3):672-6. Unique Identifier : AIDSLINE MED/20275474
- Suzuki S; Shimada T; Department of Biochemistry and Molecular Biology, Nippon Medical; School, Tokyo, 113-8602, Japan.
- An expression vector encoding a chimeric envelope protein composed of CD4 and ecotropic retroviral envelope glycoprotein was constructed with the aim of accomplishing targeted gene transfer into HIV-1-infected cells. The chimeric protein was efficiently expressed and transported to the surfaces of various cell types a
- Mechanism of action in thalidomide teratogenesis.
- Biochem Pharmacol. 2000 Jun 15;59(12):1489-99. Unique Identifier : AIDSLINE MED/20261298
- Stephens TD; Bunde CJ; Fillmore BJ; Department of Biological Sciences, Idaho State University,; Pocatello, ID, USA. steptren@isu.edu
- In this commentary, we describe a model to explain the mechanism of the embryopathy of thalidomide. We propose that thalidomide affects the following pathway during development: insulin-like growth factor I (IGF-I) and fibroblast growth factor 2 (FGF-2) stimulation of the transcription of alphav and beta3 integrin sub
- Cidofovir: new preparation. Of help in CMV retinitis.
- Prescrire Int. 1998 Oct;7(37):135-7. Unique Identifier : AIDSLINE HTA/00446085
- (1) Cidofovir is an antiviral drug indicated for intravenous treatment of cytomegalovirus retinitis in patients with AIDS. (2) The evaluation file is limited. (3) The cidofovir dose regimen (one infusion of 5 mg/kg once a week for fifteen days then once every fifteen days) was dete
- Nevirapine: new preparation. In second-line triple-drug anti-HIV regimens.
- Prescrire Int. 1998 Oct;7(37):140-1. Unique Identifier : AIDSLINE HTA/00446087
- (1) Nevirapine is the first non nucleoside inhibitor of HIV-1 reverse transcriptase to be marketed in France . (2) The clinical file comprises three comparative double-blind trials. One showed a better clinical benefit (in terms of disease progression or death) of a three-drug regi
- New EEOC guidance details responsibilities for job accommodation.
- AIDS Policy Law. 1999 Apr 2;14(6):1, 8. Unique Identifier : AIDSLINE AIDS/20700488
- The Equal Employment Opportunity Commission (EEOC) released new guidelines on how employers should accommodate the needs of workers with disabilities. Guidelines address using leave as an accommodation, the duty of offering reassignment as a form of reasonable accommodation, and an employer s cost of accommodation. Am
- New York issues draft rules for notification, surveillance.
- AIDS Policy Law. 1999 Apr 2;14(6):1, 6-7. Unique Identifier : AIDSLINE AIDS/20700489
- New York s rules for partner notification and HIV case surveillance have been condemned by HIV policy advocates. The proposed rules require diagnostic laboratories or physicians to inform State or local health departments of the names of people whose HIV antibody or viral load tests are positive. Anonymous testing rem
- Downward departure made despite lack of AIDS diagnosis.
- AIDS Policy Law. 1999 Apr 2;14(6):2. Unique Identifier : AIDSLINE AIDS/20700490
- A Senior U.S. District judge in New York provided early release to a man convicted of conspiring to traffic in cocaine because, the judge said, the prisoner s advanced HIV disease warranted a shortening of the sentence. While courts are allowed to make such judgments, they differ on what level of disease severity qual
- Los Angeles asks court to rehear religious rights case.
- AIDS Policy Law. 1999 Apr 2;14(6):3. Unique Identifier : AIDSLINE AIDS/20700491
- A three-judge panel of the U.S. Circuit Court of Appeals has been asked to rehear an Alaskan case joined by the City of Los Angeles allowing landlords to discriminate on the basis of marital status. Such a decision has implications for gay and lesbian couples and potentially for people living with HIV. The original la
- Girl scouts face complaints over reluctance to admit girl.
- AIDS Policy Law. 1999 Apr 2;14(6):4-5. Unique Identifier : AIDSLINE AIDS/20700492
- A claim filed by the Legal Action Center alleges that the Girl Scouts USA and the Adirondack Girl Scout Council discriminated against 8-year-old Quashawn Donovan by refusing to admit her because she has HIV. One complaint, filed in the New York State s Division of Human Rights, alleged that the Adirondack Council deni
- Jury awards former employee $1.28 million in ADA lawsuit.
- AIDS Policy Law. 1999 Apr 2;14(6):5. Unique Identifier : AIDSLINE AIDS/20700493
- A U.S. District Court jury in New York awarded $1.28 million to Robert J. Disanto, who was dismissed from McGraw-Hill Inc., based on his HIV infection. The company contended that Disanto did not qualify for Americans with Disabilities Act (ADA) protection because his HIV infection and depression did not substantially
- Legislative update.
- AIDS Policy Law. 1999 Apr 2;14(6):9. Unique Identifier : AIDSLINE AIDS/20700494
- Updates are presented from nine States on HIV-related legislation. Legislative topics include HIV case surveillance, testing, corrections, safety of health-care workers, HIV status notification, the definition of disability, viatical settlements, and confidentiality breaches.
- California settles lawsuit by AIDS Healthcare Foundation.
- AIDS Policy Law. 1999 Apr 2;14(6):10. Unique Identifier : AIDSLINE AIDS/20700495
- The California Department of Health Services agreed to settle a lawsuit alleging it withheld funding from the AIDS Healthcare Foundation (AHF) in retaliation for AHF s advocacy on behalf of its clients. The public protest arose when the department attempted to cite one of the AHF hospices for not having a licensed nur
- Desire for better HIV care does not justify prison escape.
- AIDS Policy Law. 1999 Apr 2;14(6):10-1. Unique Identifier : AIDSLINE AIDS/20700496
- An HIV-positive prisoner, who attempted to escape from what he believed were inferior medical conditions, was not justified in his escape, a Louisiana appeals court ruled. Brian Bush tried to escape a Louisiana prison because he expected to be returned to a Nevada prison, where he believed HIV medical treatment was in
- Motorist loses suit seeking money damages over 'HIV POS' tag.
- AIDS Policy Law. 1999 Apr 2;14(6):11. Unique Identifier : AIDSLINE AIDS/20700497
- In July, a Federal judge ruled against the California Department of Motor Vehicles (DMV) which did not allow Kevin Dimmick to have his license plate read HIV POS. Dimmick lost a second suit. The second case, U.S. District Judge Susan Illston found, had no basis for the claim that the DMV had engaged in disability-ba
- HIV reporting.
- AIDS Policy Law. 1999 Apr 2;14(6):12. Unique Identifier : AIDSLINE AIDS/20700498
- The Washington State Board of Health unanimously approved the drafting of a rule requiring the use of coded identifiers, rather than names, for HIV case reporting. Physicians and labs would report the names of people who test positive to county health departments for use in epidemiological studies. The names would be
- Hemophilia lawsuit.
- AIDS Policy Law. 1999 Apr 2;14(6):12. Unique Identifier : AIDSLINE AIDS/20700499
- A Louisiana Parish Civil District Court judge threw out a jury award of $35.3 million to a couple whose hemophiliac son died of AIDS-related complications after receiving contaminated blood-clotting products. The judge threw out the award because the couple filed the suit after the statute of limitations ran out in 19
- Criminal exposure.
- Unique Identifier : AIDSLINE AIDS/20700500
- A Milwaukee County Circuit Court issued a sentence to a man who knowingly attempted to infect his sexual partner with HIV. Antonio Dewayne Buford was sentenced to 3 months in jail, 3 months of electronic monitoring at home, and 5 years probation for having unprotected sex after getting HIV from another person. The no
- Making tough choices: HIV ethical decision making.
- Focus. 1999 May;14(6):1-4. Unique Identifier : AIDSLINE AIDS/20700501
- A panel of the American Psychological Association (APA) has developed a simple, user friendly process to facilitate ethical and clinical decision making in cases involving HIV disease. The model is based on the five ethical principles of autonomy, beneficence, nonmaleficence, fidelity, and justice. This article examin
- Clearinghouse: ethics and therapy.
- Focus. 1999 May;14(6):4-5. Unique Identifier : AIDSLINE AIDS/20700502
- Resources are listed for those interested in the subject of ethics and psychotherapy involving patients with HIV/AIDS. American Journal of Psychotherapy and Harvard Review of Psychiatry are among the resources mentioned. Contact information for several organizations is also provided.
- HIV, the right to die, and control.
- Focus. 1999 May;14(6):5-6. Unique Identifier : AIDSLINE AIDS/20700503
- The issue of the right to die in cases involving patients with HIV/AIDS is examined. Physician-assisted suicide is addressed along with issues pertaining to control and choice in the assisted dying debate. In particular, it is noted that there is an increasing awareness of an overriding desire for self-determination i
- CDC advocates names, but doesn't rule out use of coded identifiers. Centers for Disease Control and Prevention.
- AIDS Policy Law. 1999 Dec 24;14(22):1, 10. Unique Identifier : AIDSLINE AIDS/20700504
- The Centers for Disease Control and Prevention (CDC), while preferring that states track HIV cases using names, will cooperate with jurisdictions that use coded identifiers instead. Under the final CDC guidelines on HIV case surveillance, public health officials are to log in a patient identifier (name or code), an ea
- Congress fails to fully fund Ricky Ray hemophilia relief bill.
- AIDS Policy Law. 1999 Dec 24;14(22):1, 12. Unique Identifier : AIDSLINE AIDS/20700505
- Congress failed to fully fund the promised $750 million mandated by the Ricky Ray Hemophilia Relief Act. Funds go to HIV-positive hemophiliacs as compensation for lax regulation of the nation s blood supply in the early 1980s. The government passed the fund from the Justice Department to the Department of Health and H
- Violation of health order leads to prison sentence.
- AIDS Policy Law. 1999 Dec 24;14(22):2. Unique Identifier : AIDSLINE AIDS/20700506
- The Mississippi Court of Appeals upheld the conviction of an HIV-positive man who, despite a public health order to warn his sexual partners that he was HIV-positive, engaged in sex without doing so. The court found Philip Carter had disregarded the quarantine order issued by the State in March 1992. Carter was given
- Suit to proceed in claim that pharmacy revealed HIV status.
- AIDS Policy Law. 1999 Dec 24;14(22):3. Unique Identifier : AIDSLINE AIDS/20700507
- A Federal judge in Milwaukee left intact a claim that the Osco Drug Store chain negligently caused John Doe emotional distress and exposed him to harassment. The store published, without his permission, his letter of thanks to an Osco pharmacist for helping him to obtain the protease inhibitor
- GAO audit not apt to find pervasive fraud in CARE Act.
- AIDS Policy Law. 1999 Dec 24;14(22):4. Unique Identifier : AIDSLINE AIDS/20700508
- After hearing a series of news reports suggesting financial improprieties in programs run by Ryan White CARE Act recipients, a General Accounting Office (GAO) review of the program was made. A preliminary GAO report found only a few cases of fraud in the administration of funding stemming from the CARE Act, but that t
- Washington upholds HIV exposure law as constitutional.
- AIDS Policy Law. 1999 Dec 24;14(22):5. Unique Identifier : AIDSLINE AIDS/20700509
- A Washington State appeals court has rejected a constitutional challenge to a law that makes the intentional spreading of HIV to sex partners a crime. The court rejected the notion that the criminal exposure law violated the equal protection clause of the U.S. and State constitutions because it singled out those infec
- Congress approves higher funding for all key AIDS programs.
- AIDS Policy Law. 1999 Dec 24;14(22):6. Unique Identifier : AIDSLINE AIDS/20700510
- Congress passed a $390 billion omnibus appropriations bill boosting funding for all major AIDS programs. Generous funds are provided for research and drug assistance and limited funds for the treatment of substance abuse. The bill increased HIV-related prevention spending by 6 percent, which AIDS Action criticized as
- If you thought this year was difficult, wait until next year.
- AIDS Policy Law. 1999 Dec 24;14(22):7. Unique Identifier : AIDSLINE AIDS/20700511
- Despite a budgetary surplus for the year 2000, budget constraints for next year s funding of AIDS programs will be even greater. In 2000, voters will elect a new President, one-third of the Senate, and all of the House of Representatives. Such election conditions will greatly politicize the funding process. Daniel Zin
- Effective discharge planning seen as vital for public heatlh.
- AIDS Policy Law. 1999 Dec 24;14(22):8. Unique Identifier : AIDSLINE AIDS/20700512
- Public health agencies need to find out how to link recently-released, HIV-infected prison inmates to care and treatment services. Currently, this type of planning is practiced in few corrections facilities. Many merely provide a list of phone numbers where medical treatment and support services can be arranged. Inmat
- Hampden county: a model for seamless care.
- AIDS Policy Law. 1999 Dec 24;14(22):9. Unique Identifier : AIDSLINE AIDS/20700513
- The Hampden County Correctional Center is helping to create a model program of correctional health care. The program objective is to provide comprehensive care that will continue seamlessly upon the release of the inmate from jail. The discharge planning process recognizes the existence of other problems such as alcoh
- Michigan DOC: discharge planning starts early.
- AIDS Policy Law. 1999 Dec 24;14(22):9. Unique Identifier : AIDSLINE AIDS/20700514
- The Michigan Department of Corrections discharge planning system for released, HIV-positive inmates is described. Care is managed locally through community-based case managers, and patient education is an important part of the care process. As the release date nears, case managers help inmates complete the paperwork
- Oregon eyes a hybrid reporting plan using names, codes.
- AIDS Policy Law. 1999 Dec 24;14(22):11. Unique Identifier : AIDSLINE AIDS/20700515
- The Oregon Department of Human Services has decided to try tracking HIV cases with a hybrid use of names and coded identifiers. Public health workers will convert each name to a code and then the names will be purged from their databases once all necessary data are collected and the cases are connected to medical and
- Bank, leasing agent settle bias claim by HIV service provider.
- AIDS Policy Law. 1999 Dec 24;14(22):11. Unique Identifier : AIDSLINE AIDS/20700516
- The Howard Brown Health Center, the largest gay and lesbian health provider in the Midwest, has settled a suit it filed against Hyde Park Bank and Aegis Properties Corp. The center claimed that its repeated attempts to lease space in the Hyde Park Bank building were allegedly refused because the Center s services were
- HIV decontaminant figures in bogus investment scheme.
- AIDS Policy Law. 1999 Dec 24;14(22):13. Unique Identifier : AIDSLINE AIDS/20700517
- The 11th U.S. Circuit Court of Appeals upheld the conviction of F. O. Majors and his son Gareth for defrauding investors of $3.3 million. The men operated schemes promoting a phony cleaning fluid to kill HIV and a secret formula for a synthetic fuel additive. The court rejected the defendants argument that they did
- Patient's fears were justified because doctor advised tests.
- AIDS Policy Law. 1999 Dec 24;14(22):13. Unique Identifier : AIDSLINE AIDS/20700518
- A Connecticut physician faces liability charges for advising a patient to seek HIV testing after surgery was performed using unsterilized instruments. The court allowed the defendant, Dani Ayotte, to sue Dr. Richard Kates for emotional distress because the doctor created a foreseeability of distress regarding possib
- HIV cases in U.S. range from 800,000 to 900,000.
- AIDS Policy Law. 1999 Dec 24;14(22):13. Unique Identifier : AIDSLINE AIDS/20700519
- The Centers for Disease Control and Prevention (CDC) estimates that the number of HIV infections in the United States at the end of 1998 ranged from 800,000 to 900,000. The annual number of new infections has remained stable at about 40,000 since 1992. It is impossible to know exactly
- Girl Scouts settle complaints over reluctance to admit girl.
- AIDS Policy Law. 1999 Dec 24;14(22):14. Unique Identifier : AIDSLINE AIDS/20700520
- The Girl Scouts have settled a claim of discrimination made against New York s Adirondack Girl Scout Council and the national Girl Scouts organization for refusing admittance of a third-grader into the Brownies because of her HIV infection. The settlement occurred without adjudication on the key point of whether volun
- Immigrant didn't qualify for medical necessity defense.
- AIDS Policy Law. 1999 Dec 24;14(22):15. Unique Identifier : AIDSLINE AIDS/20700521
- The 8th U.S. Circuit Court of Appeals upheld a conviction of Fernando Diaz-Diaz for unlawful entry into the United States . The court rejected the defendant s argument of medical necessity due to his inability to pay for HIV medication in Mexico . The
- Two men imprisoned for murders of partners who exposed them to HIV.
- AIDS Policy Law. 1999 Dec 24;14(22):15. Unique Identifier : AIDSLINE AIDS/20700522
- The issue of AIDS rage has appeared in the courts. A Minnesota judge sentenced Michael C. Stewart to 39 years in prison for killing Amanda Carlson-Bey, his pregnant ex-girlfriend, and their 2-year-old son, after Carlson-Bey revealed she was HIV-positive. In Michigan, James Summerville, Jr. was sentenced to life in p
- Lab settles testing suit.
- AIDS Policy Law. 1999 Dec 24;14(22):16. Unique Identifier : AIDSLINE AIDS/20700523
- Lawrence Berkeley Laboratory has agreed to pay $2.2 million to settle employees claims that their blood was tested for sexually transmitted diseases, pregnancy, and genetic predisposition to sickle cell without the employees knowledge. The 9th U.S. Circuit Court of Appeals rejected the defendant s assertion that the
- Guilty of embezzlement.
- AIDS Policy Law. 1999 Dec 24;14(22):16. Unique Identifier : AIDSLINE AIDS/20700524
- Corey E.C. White pleaded guilty to embezzling $215,189 from the Central Florida AIDS Unified Resources (CENTAUR) where she worked until February. Additionally, the Orange County Sheriff s Office is investigating the disappearance of $350,063 from the Local Health Council of East Central Florida where she had worked pr
- HIV is underestimated.
- AIDS Policy Law. 1999 Dec 24;14(22):16. Unique Identifier : AIDSLINE AIDS/20700525
- Results of a New York City survey show that residents view AIDS as the leading health problem, but they underestimate the spread of the epidemic in their neighborhoods. Survey results showed half of the respondents thought about 100 individuals with HIV lived in their community; in fact, 3,200 HIV-positive people, on
- Petition drive.
- AIDS Policy Law. 1999 Dec 24;14(22):16. Unique Identifier : AIDSLINE AIDS/20700526
- Nearly 800 physicians and nurses petitioned the governor of Massachusetts to declare a public health emergency and expand needle-exchange programs in the state. Currently, needle-exchange programs are operated in only four communities: Boston, Cambridge, Provincetown, and Northampton. Injection drug use is the highest
- Beyond complacency: the effects of treatment on HIV transmission.
- Focus. 1999 Apr;14(5):1-4. Unique Identifier : AIDSLINE AIDS/20700527
- Halkitis PN; Wilton L; Center for HIV/AIDS Educational Studies and Training.
- The novel optimistic view of the HIV epidemic, which seems to be associated with the success of HIV antiviral therapy and prevention, may lead to an increase in the number of HIV infected people. Overall, risky sexual behaviors are increasing due to optimism regarding the manageability and reduced threat of HIV diseas
- Clearinghouse: treatment/prevention.
- Focus. 1999 Apr;14(5):4-5. Unique Identifier : AIDSLINE AIDS/20700528
- Ten annotated references on HIV/AIDS treatment and prevention articles are listed. Topics include antiretroviral, psychological and psychiatric treatments, as well as therapy adherence. In addition, contact information on three organizations involved in HIV social research, applied psychology, and advocacy is provided
- Sexual agreements between men in relationships.
- Focus. 1999 Apr;14(5):5-7. Unique Identifier : AIDSLINE AIDS/20700529
- Crawford J; Kippax S; Van de Ven P; University of New South Wales, National Centre in HIV Social; Research, Sydney, Australia.
- The range of sexual agreements among gay men regarding anal intercourse is explored. The article focuses on negotiated safety, and the results of a recent study on this type of agreement and its relation to risk behavior. When sexual partners engage in negotiated safety agreements, they usually do not practice unsafe
- Drinking and HIV: knowledge and context.
- Focus. 1999 Mar;14(4):1-4. Unique Identifier : AIDSLINE AIDS/20700530
- Bryant KJ; Levine GL; National Institutes of Health, National Institute on Alcohol; Abuse and Alcoholism.
- The unique role of alcohol consumption on the AIDS epidemic is examined, as are the gaps in knowledge that exist among patients, practitioners, and researchers. Research on how alcohol abuse enhances unsafe sex practices and nonadherence to AIDS medication regimens is discussed. In addition, the effects of drinking, w
- Clearinghouse: alcohol and poppers.
- Focus. 1999 Mar;14(4):4-5. Unique Identifier : AIDSLINE AIDS/20700531
- Ten articles from magazines and journals are referenced on the subjects of alcohol and poppers. Topics include alcohol consumption and HIV/AIDS-related risky sexual behavior, alcohol and drug abuse, and self-esteem, gender, and alcohol use. Contact information is provided.
- The poppers-HIV connection.
- Focus. 1999 Mar;14(4):5-6. Unique Identifier : AIDSLINE AIDS/20700532
- Nitrite inhalants called poppers are receiving renewed attention by researchers regarding the drug s role in the gay community, its contribution to risky sexual behavior, and its ability to fuel the AIDS epidemic. Research shows the effects of poppers cause a euphoria that can reduce inhibitions, increase sexual dri
- Risk, HIV, and STD prevention.
- Focus. 1999 Jun;14(7):1-4. Unique Identifier : AIDSLINE AIDS/20700533
- The risk of becoming infected with HIV and other sexually transmitted diseases (STDs) is discussed. The concept of risk is defined in three ways: the risk of exposure to an infectious agent, the risk of infection after exposure, and the risk of severe consequences after infection. Determining the most effective STD pr
- Clearinghouse: STDs and HIV.
- Focus. 1999 Jun;14(7):4-5. Unique Identifier : AIDSLINE AIDS/20700534
- A list of 13 references on sexually transmitted diseases and HIV is provided. Journals referenced include Journal of Hepatology and European Journal of Medical Research. Contact information for three organizations where additional information can be obtained is provided.
- An overview of sexually transmitted diseases.
- Focus. 1999 Jun;14(7):5-6. Unique Identifier : AIDSLINE AIDS/20700535
- Brief summaries of the rate of infection and symptoms are provided for the following major sexually transmitted diseases (STDs): herpes simplex virus type 2, human papilloma viruses, trichomoniasis, chlamydia, gonorrhea, hepatitis B, and syphilis. Because STDs increase susceptibility to HIV and other serious complicat
- Amprenavir (Agenerase) receives FDA approval. Food and Drug Administration.
- Unique Identifier : AIDSLINE AIDS/20700536
- Highleyman L
- The Food and Drug Administration ( FDA ) has approved amprenavir
- Protease inhibitors and sildenafil (Viagra) should not be combined.
- BETA. 1999 Apr;12(2):3. Unique Identifier : AIDSLINE AIDS/20700537
- Highleyman L
- The European Agency for the Evaluation of Medicinal Products (EMEA) issued a warning in April 1999, about potential adverse effects when the impotence drug sildenafil (Viagra) is taken with protease inhibitors . In particular, sildenafil and
- Two new HIV blood tests.
- BETA. 1999 Apr;12(2):4. Unique Identifier : AIDSLINE AIDS/20700538
- Highleyman L
- The FDA approved a more sensitive version of the polymerase chain reaction (PCR) HIV viral load blood test in March 1999. Roche Molecular Systems Amplicor HIV-1 Monitor Ultrasensitive can detect viral loads as low as 500 copies/mL of plasma. It has been used in clinical trials since
- Abbott seeks approval of new Ritonavir capsule.
- BETA. 1999 Apr;12(2):4. Unique Identifier : AIDSLINE AIDS/20700539
- Highleyman L
- Abbott Laboratories is seeking approval to produce and market a new soft-gel capsule formulation of its protease inhibitor, Ritonavir ( Norvir ). A
- 3TC approved for children.
- BETA. 1999 Apr;12(2):5. Unique Identifier : AIDSLINE AIDS/20700540
- Highleyman L
- In March, the FDA approved the use of 3TC ( Epivir or Lamivudine ) for HIV positive
- Annual colposcopies and pap smears recommended for women with HIV.
- BETA. 1999 Apr;12(2):6. Unique Identifier : AIDSLINE AIDS/20700541
- Highleyman L
- A new study presented by Annekathryn Goodman of Massachusetts General Hospital indicates that HIV positive women should receive annual colposcopies, along with Pap smears, to detect abnormal cell growth early. The recommendation is due to the fact that HIV positive women are more likely to have false-negative Pap smea
- Major vaccine trials begin.
- BETA. 1999 Apr;12(2):6. Unique Identifier : AIDSLINE AIDS/20700542
- Highleyman L
- March 8 marked the beginning of the first HIV vaccine effectiveness trial in the San Francisco Bay Area, being conducted by the San Francisco Department of Public Health and the University of California at San Francisco. This phase III trial is expected to run four years in more than 50 locations, and enroll 5,000 par
- Many PWAs missing out on treatment.
- BETA. 1999 Apr;12(2):6, 21. Unique Identifier : AIDSLINE AIDS/20700543
- Highleyman L
- A RAND study shows that half of all persons with HIV in the U.S. are not receiving treatment. Of those in treatment, one-third are not receiving combination therapy as recommended by Federal guidelines. The HIV Cost and Services Utilization Study surveyed 160 physician
- New anti-HIV drugs in development.
- BETA. 1999 Apr;12(2):7-8. Unique Identifier : AIDSLINE AIDS/20700544
- Highleyman L
- Several new anti-HIV drugs have received Food and Drug Administration ( FDA ) approval in the past three years, following a period of intense research in the mid-1990s. That cycle of research and development appears to have shifted, with only one drug expected to receive approval in the
- Calanolide A: a natural non-nucleoside reverse transcriptase inhibitor.
- BETA. 1999 Apr;12(2):8-9. Unique Identifier : AIDSLINE AIDS/20700545
- Hanna L
- Calanolide A, an experimental non-nucleoside reverse transcriptase inhibitor, is a synthetic version of a compound found in nature. The natural form of the drug comes from the latex produced by a tree native to the tropical rain forest of Sarawak, Malaysia , and was discovered by
- HAART attack: metabolic disorders during long-term antiretroviral therapy.
- BETA. 1999 Apr;12(2):10-4. Unique Identifier : AIDSLINE AIDS/20700546
- David E
- HIV infection has long been associated with changes in body metabolism, most notably in the form of AIDS wasting and in fat distribution changes. Abnormalities in blood lipid levels are associated with antiviral treatment, and the introduction of highly active antiretroviral therapy (HAART) has caused more cases of hi
- Diabetes in women taking protease inhibitors.
- BETA. 1999 Apr;12(2):15-6. Unique Identifier : AIDSLINE AIDS/20700547
- Hanna L
- An ongoing study, the Women s Interagency HIV Study (WIHS), evaluated the rate of diabetes mellitus (DM) in their cohort of HIV-positive women. The study enrolled 2,000 HIV-positive and 500 HIV-negative women. The women who were divided into groups based on their experience with antiretrovirals, were followed at regul
- HIV prevalence remains stable in U.S. women through 1994.
- BETA. 1999 Apr;12(2):16. Unique Identifier : AIDSLINE AIDS/20700548
- Hanna L
- According to researchers at the CDC, HIV prevalence in U.S. women of childbearing age is about 1.6 cases per 1,000 women, which has remained stable from 1989 to 1994. The infection rate has remained low for women in the West and Midwest and has declined in the Northeast. Though overall infection rates have leveled off
- Study to address effects of antiretroviral therapy on women.
- BETA. 1999 Apr;12(2):16. Unique Identifier : AIDSLINE AIDS/20700549
- Hanna L
- Women comprise 45 percent of new HIV infections, but account for only 9 to 20 percent of clinical research participants. Hoffmann-La Roche is conducting a study to evaluate potential differences in response to antiretroviral drug therapy based on gender. The study will enroll 60
- HAART and HPV infection.
- BETA. 1999 Apr;12(2):16. Unique Identifier : AIDSLINE AIDS/20700550
- Hanna L
- A study on women presented by L. Andieh at the 6th CROI evaluated the influence of highly active antiretroviral therapy (HAART) on infection with the human papillomavirus (HPV), which causes genital warts and is associated with genital cancers. When the study began, 82 percent of the 141 HIV positive women enrolled we
- HPV and neoplasia: notes from CROI.
- BETA. 1999 Apr;12(2):17. Unique Identifier : AIDSLINE AIDS/20700551
- Hanna L
- Women with HIV are more likely to have recurrent HPV infections and neoplasia, precancerous or cancerous tissue changes, than HIV-negative women. Women with advanced HIV seem to be at an even greater risk level when compared to healthier HIV-positive women. A study looked at vaginal secretions and infections from appr
- Vitamin A and HPV.