2000
- HIV-1 infects and alters immune function of a monocyte subset expressing low CD14 surface phenotype.
- Viral Immunol. 2000;13(1):19-26. Unique Identifier : AIDSLINE MED/20195303
- Hardegen NJ; Toro LA; Muller J; Wahl LM; Hewlett IK; Dhawan S; Immunopathology Section, National Institute of Dental and; Craniofacial Research, National Institutes of Health, Bethesda,; MD, USA.
- Monocytes represent a leukocyte subset that express high levels of CD14 on their surface (CD14-high). These cells play a critical role in the pathogenesis of HIV-1 infection. In the present study, we have identified a monocyte subset expressing an extremely low level of CD14 (CD14-low), and examined their susceptibili
- HIV-DNA vaccination following transfer of a large number of activated T cells enhances immunoresponses against HIV-1.
- Viral Immunol. 2000;13(1):3-8. Unique Identifier : AIDSLINE MED/20195301
- Hamajima K; Xin KQ; Fukushima J; Yang J; Honsho A; Nakazawa M; Yanoma S; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, Japan.
- HIV gp120 plus specific peptides are recognized in a similar manner to specific HLA plus peptide by HLA-restricted antigen-specific T-cell lines.
- Viral Immunol. 2000;13(1):9-17. Unique Identifier : AIDSLINE MED/20195302
- Sheikh J; Souberbielle B; Westby M; Austen B; Dalgleish AG; Division of Surgery, St. George's Hospital Medical School,; Tooting, London, UK.
- HIV induces disease only following chronic activation of the immune system. Other retroviruses such as the mouse mammary tumour virus (MMTV) activate a large percentage of T cells by encoding a superantigen (SAg). To date there is no evidence that HIV encodes a SAg. An alternative way to induce pan-activation of the i
- Ethnic and racial differences in long-term survival from hospitalization for HIV infection.
- J Health Care Poor Underserved. 2000 May;11(2):163-78. Unique Identifier : AIDSLINE MED/20253983
- Cunningham WE; Mosen DM; Morales LS; Andersen RM; Shapiro MF; Hays RD; Department of Health Services, School of Public Health,; University of California, Los Angeles 90095, USA.
- This prospective cohort study compares 200 hospitalized, HIV-infected patients (Hispanic, African American, and white) from May 1992 to October 1998 to assess mortality (versus survival) over 75 months of follow-up. The relative risk of six-year mortality for each ethnic group is compared using Cox proportional hazard
- Diffuse toxoplasmic retinochoroiditis as the initial manifestation of acquired immunodeficiency syndrome.
- J Formos Med Assoc. 2000 Mar;99(3):219-23. Unique Identifier : AIDSLINE MED/20280589
- Lee YF; Chen SJ; Chung YM; Liu JH; Wong WW; Department of Ophthalmology, Taipei Veterans General Hospital,; National Yang-Ming University, School of Medicine, Taiwan.
- Toxoplasmic retinochoroiditis is an important opportunistic retinal infection in human immunodeficiency virus (HIV)-infected patients. It may present as diffuse necrotizing retinochoroiditis instead of a focal lesion and may be the initial manifestation of HIV infection. A 50-year-old heterosexual man presented with b
- South Africa to tighten control on drug trials after five death [news]
- BMJ. 2000 Apr 15;320(7241):1028. Unique Identifier : AIDSLINE MED/20227657
- Sidley P
- AIDS patients in South Africa to get free drug [news]
- BMJ. 2000 Apr 22;320(7242):1095. Unique Identifier : AIDSLINE MED/20237349
- Sidley P
- Unlike GMC, GP did not follow line of political correctness [letter; comment]
- BMJ. 2000 Apr 22;320(7242):1148. Unique Identifier : AIDSLINE MED/20237380
- Newmark J
- [Hepatitis C: viral load and plasma lipids (letter)]
- Gastroenterol Hepatol. 2000 Mar;23(3):149. Unique Identifier : AIDSLINE MED/20264816
- Escolar JL; Gavilan JC; Rivera A; Clavijo E
- Therapeutic implications of recent data on immune pathogenesis of HIV disease [editorial]
- AIDS Patient Care STDS. 1999 Aug;13(8):449-51. Unique Identifier : AIDSLINE MED/20260316
- Laurence J
- Surviving the fall: an AIDS caregiver's journey.
- AIDS Patient Care STDS. 1999 Aug;13(8):453-7. Unique Identifier : AIDSLINE MED/20260317
- Selwyn PA; Department of Family Medicine, Albert Einstein College of; Medicine, Bronx, New York, USA. selwyn@aecom.yu.edu
- Kala-azar as an AIDS-related opportunistic infection.
- AIDS Patient Care STDS. 1999 Aug;13(8):459-65. Unique Identifier : AIDSLINE MED/20260318
- Murray HW; Department of Medicine, Cornell University Medical College, New; York, New York, USA.
- Visceral leishmaniasis (kala-azar) is a worldwide disseminated protozoal infection primarily transmitted by sand flies. Because host defense against this intracellular infection is T-cell-dependent, kala-azar has predictably joined the list of AIDS-related opportunistic infections in endemic areas. The vast majority o
- Rifabutin prophylaxis against Mycobacterium avium complex infections in HIV-infected patients: impact on the incidence of campylobacteriosis.
- AIDS Patient Care STDS. 1999 Aug;13(8):467-72. Unique Identifier : AIDSLINE MED/20260319
- Pulik M; Genet P; Leturdu F; Lionnet F; Louvel D; Touahri T; Department of Hematology, Victor Dupouy Hospital, Argenteuil,; France.
- Following the observation of the decreasing occurrence of campylobacteriosis in HIV-infected patients. This study examines the incidence of campylobacteriosis in patients who had received rifabutin prophylaxis against Mycobacterium avium complex (MAC) infection compared with the incidence observed among patients treat
- Clinician judgement as a tool for targeting HIV counseling and testing in North Carolina state mental hospitals, 1994.
- AIDS Patient Care STDS. 1999 Aug;13(8):473-9. Unique Identifier : AIDSLINE MED/20260320
- Kirkland KB; Meriwether RA; MacKenzie WR; Binz WC; Allen RJ; Veenhuis PE; Department of Environment, Health and Natural Resources, Raleigh,; North Carolina, USA.
- HIV infection increasingly affects populations that may not appear at high risk based on the use of some traditional targeting strategies. To shed some light on how to more sensitively/effectively identify people who need routine HIV testing and counseling, the objective of this study is to determine the prevalence of
- Home away from home: essential elements in developing housing options for people living with HIV/AIDS.
- AIDS Patient Care STDS. 1999 Aug;13(8):481-91. Unique Identifier : AIDSLINE MED/20260321
- Stajduhar KI; Lindsey E; School of Nursing, University of British Columbia, Vancouver.; magenta@bc.sympatico.ca
- There is a paucity of data to enlighten our understanding regarding the need for a respite care/supported living home for people living with HIV/AIDS (PLWHIV/AIDS) and to identify the essential elements required to initiate this endeavor. Participatory action research was used in this study as the process by which the
- Use of stage of change (SOC) to develop an STD/HIV behavioral intervention: phase 1. A system to classify SOC for STD/HIV sexual risk behaviors--development and reliability in an STD clinic.
- AIDS Patient Care STDS. 1999 Aug;13(8):493-502. Unique Identifier : AIDSLINE MED/20260322
- Coury-Doniger P; Levenkron JC; Knox KL; Cowell S; Urban MA; Department of Medicine, University of Rochester School of; Medicine and Dentistry, New York, USA.
- This paper reports on the initial phase in the development, program implementation, and inter-rater reliability of an application of Stage of Change (SOC) behavioral theory for use in STD/HIV risk reduction. SOC was adapted to assess readiness for sexual behavior change in an urban STD clinic in Rochester, New York. A
- College educated most likely to get PIs [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):503. Unique Identifier : AIDSLINE MED/20260323
- AZT incorporates into leukocyte DNA [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):504. Unique Identifier : AIDSLINE MED/20260325
- Efavirenz approved in Europe [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):504. Unique Identifier : AIDSLINE MED/20260324
- Nevirapine and methadone withdrawal [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):504. Unique Identifier : AIDSLINE MED/20260326
- Treatment of vaginal infections [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):505. Unique Identifier : AIDSLINE MED/20260327
- Stress and lack of social support hastens HIV disease: most compelling evidence to date [news]
- AIDS Patient Care STDS. 1999 Aug;13(8):507-8. Unique Identifier : AIDSLINE MED/20260333
- Makulowich GS
- HIV in prison; HIV and killer T cells [editorial]
- AIDS Patient Care STDS. 2000 Mar;14(3):105-7. Unique Identifier : AIDSLINE MED/20226748
- Laurence J
- HIV in China: an opportunity to halt an emerging epidemic.
- AIDS Patient Care STDS. 2000 Mar;14(3):109-12. Unique Identifier : AIDSLINE MED/20226749
- Ammann AJ; Center for AIDS Prevention, University of California Medical; Center, San Francisco, USA.
- HIV risk and healthcare attitudes among detained adolescents in rural Alabama.
- AIDS Patient Care STDS. 2000 Mar;14(3):113-24. Unique Identifier : AIDSLINE MED/20226750
- Lichtenstein B; University of Alabama at Birmingham, USA.; blichten@sbs.sbs.uab.edu
- This qualitative study explored the dynamics of adolescent HIV risk through focus group interviews of male and female adolescents at an Alabama juvenile detention facility, key informant interviews, and through interviews of HIV-positive and negative adults in institutional settings and public health clinics in Alabam
- Antenatal screening for HIV infection.
- AIDS Patient Care STDS. 2000 Mar;14(3):125-31. Unique Identifier : AIDSLINE MED/20226751
- Gibb DM; Medical Research Council Clinical Trials Unit, Mortimer Market; Center, UCLMS, London, United Kingdom. D.Gibb@ctu.mrc.ac.uk
- Cystic lymphoepithelial lesions of the parotid gland in HIV-1 infection.
- AIDS Patient Care STDS. 2000 Mar;14(3):143-7. Unique Identifier : AIDSLINE MED/20226753
- Uccini S; D'Offizi G; Angelici A; Prozzo A; Riva E; Antonelli G; Baroni CD; Ruco LP; Department of Experimental Medicine, University La Sapienza,; Rome, Italy. s_uccini@uniromal.it
- The benign cystic lymphoepithelial lesion (BLL) of the parotid gland is a rare disorder affecting HIV-1-infected patients. Here we describe the clinical and histopathological features of 10 cases of BLL, who presented to our observation between November 1992 and December 1996, before the combination antiretroviral the
- Disseminated histoplasmosis and AIDS: clinical aspects and diagnostic methods for early detection.
- AIDS Patient Care STDS. 2000 Mar;14(3):149-54. Unique Identifier : AIDSLINE MED/20226754
- Corti ME; Cendoya CA; Soto I; Esquivel P; Trione N; Villafane MF; Corbera KM; Helou S; Negroni R; Unit 10 and Micology Center, F.J. Muniz Infectious Diseases; Hospital, Buenos Aires, Argentina. marcelocorti@cuidad.com.ar
- Disseminated histoplasmosis in AIDS patients is the focus of this paper. Cutaneous lesions are reported as a frequent clinical sign. Bone marrow aspiration and biopsy, blood cultures (lysis-centrifugation technique), bronchoalveolar lavage, and skin lesion scrapings are the most effective diagnostic methods. The ident
- Barriers to and facilitators of HIV-positive patients' adherence to antiretroviral treatment regimens.
- AIDS Patient Care STDS. 2000 Mar;14(3):155-68. Unique Identifier : AIDSLINE MED/20226755
- Roberts KJ; University of California, Los Angeles, USA. kjrobert@ucla.edu
- HIV-positive patients must strictly adhere to antiretroviral regimens for the medications to work properly. Little, however, is known about the obstacles that patients face in adhering to the regimens or what, if anything, helps patients to adhere. The goals of the project were to describe, from HIV-positive patients
- New combination studied [news]
- AIDS Patient Care STDS. 2000 Mar;14(3):169-70. Unique Identifier : AIDSLINE MED/20226756
- OIs despite HAART [news]
- AIDS Patient Care STDS. 2000 Mar;14(3):170. Unique Identifier : AIDSLINE MED/20226757
- Expansion of CD60 helper lymphocytes detected in peripheral lymphocytes of HIV-1 infected individuals is not paralleled in lymph nodes.
- Eur J Med Res. 2000 Apr 19;5(4):150-6. Unique Identifier : AIDSLINE MED/20262165
- Bogner JR; Gruber R; Steckmeier B; Goebel F; Rieber EP; Med. Poliklinik, Pettenkoferstr. 8a, D-80336 Munich, Germany.; jobogner@pk-i.med.uni-muenchen.de
- BACKGROUND AND OBJECTIVE: A significant expansion of CD8 cells with capability of Th2 type helper function had been observed in hemophiliacs with HIV infection. These cells were characterised by the surface co-expression of CD8 and CD60 antigen. Our objective was to investigate this lymphocyte subset in relation to ot
- Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.
- ABOLISM Viral Proteins/GENETICS/*PHARMACOLOGY Clin Cancer Res. 2000 Mar;6(3):1180-9. Unique Identifier : AIDSLINE MED/20203794
- Hideshima T; Chauhan D; Teoh G; Raje N; Treon SP; Tai YT; Shima Y; Anderson KC; Department of Adult Oncology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.
- Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
- Clin Cancer Res. 2000 Mar;6(3):987-93. Unique Identifier : AIDSLINE MED/20203769
- Rha SY; Izbicka E; Lawrence R; Davidson K; Sun D; Moyer MP; Roodman GD; Hurley L; Von Hoff D; Cancer Therapy & Research Center, Institute for Drug Development,; The University of Texas Health Science Center at San Antonio,; 78229, USA. srha@saci.org
- Shortening of telomeres along with an up-regulation of telomerase is implicated in the immortality of tumor cells. Targeting either telomeres or telomerase with specific compounds has been proposed as an anticancer strategy. Because telomerase activity and telomeres are found in normal cells, telomere or telomerase ta
- Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species.
- Clin Chem. 2000 May;46(5):631-5. Unique Identifier : AIDSLINE MED/20256813
- Loeffler J; Hagmeyer L; Hebart H; Henke N; Schumacher U; Einsele H; Medizinische Klinik, Abteilung II, Otfried-Mueller-Strasse 10,; 72076 Tuebingen, Germany. Fax 49-7071-293179, USA.; juergen.loeffler@med.uni-tuebingen.de
- BACKGROUND: The LightCycler(TM) combines rapid amplification of nucleic acids in glass capillaries with melting curve analysis based on fluorescence resonance energy transfer for the sensitive detection of point mutations in various settings, such as drug resistance and hereditary diseases. Point mutations leading to
- Efavirenz interference in estradiol ELISA assay [letter]
- Clin Chem. 2000 May;46(5):734-5. Unique Identifier : AIDSLINE MED/20256835
- Sinicco A; Raiteri R; Rossati A; Savarino A; Di Perri G
- KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT.
- Unique Identifier : AIDSLINE MED/20245901
- Panoskaltsis-Mortari A; Ingbar DH; Jung P; Haddad IY; Bitterman PB; Wangensteen OD; Farrell CL; Lacey DL; Blazar BR
- We investigated keratinocyte growth factor (KGF) as a pretreatment therapy for idiopathic pneumonia syndrome (IPS) generated as a result of lung damage and allogeneic T cell-dependent inflammatory events occurring in the early peri-bone marrow (BM) transplant (BMT) period. B10.BR (H2(k)) recipient mice were transplant
- MAP kinase pathways activated by stress: the p38 MAPK pathway.
- Crit Care Med. 2000 Apr;28(4 Suppl):N67-77. Unique Identifier : AIDSLINE MED/20265598
- Obata T; Brown GE; Yaffe MB; Department of Medicine, Beth Israel Deaconess Medical Center,; Boston, MA, USA.
- A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase (p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and certain mitogens, trigger a stress-regulate
- Optimization of whole blood antigen-specific cytokine assays for CD4(+) T cells.
- Cytometry. 2000 May 1;40(1):60-8. Unique Identifier : AIDSLINE MED/20218907
- Nomura LE; Walker JM; Maecker HT; Biological Research and Development, BD Biosciences,; Immunocytometry Systems, San Jose, CA 95131, USA.
- BACKGROUND: The analysis of cytokine production is a valuable component of studies of immune response to stimulation such as pathogens, vaccines, and other immunological challenges. One highly sensitive method of cytokine evaluation involves three-color flow cytometric analysis of cytokine production in individual CD4
- Importance of the CD3 marker for evaluating changes in rhesus macaque CD4/CD8 T-cell ratios.
- Cytometry. 2000 May 1;40(1):69-75. Unique Identifier : AIDSLINE MED/20218908
- Dykhuizen M; Ceman J; Mitchen J; Zayas M; MacDougall A; Helgeland J; Rakasz E; Pauza CD; Wisconsin Regional Primate Research Center, Madison, WI 53706,; USA.
- BACKGROUND: Until recently, there were no CD3 antibodies that crossreacted with rhesus macaque T cells. Consequently, studies relying on CD8 counts or CD4/CD8 ratios enumerated this subpopulation on the basis of CD8+ or CD8bright+ staining. We used a rhesus-specific, anti-CD3 antibody to better define the CD8+ T-cell
- Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes.
- Folia Histochem Cytobiol. 2000;38(1):21-3. Unique Identifier : AIDSLINE MED/20226330
- Jagodzinski PP; Trzeciak WH; Department of Physiological Chemistry, University of Medical; Sciences, Poznan, Poland. pjagodzi@eucalyptus.usoms.poznan.pl
- Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals an
- Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-alpha gene.
- FASEB J. 2000 May;14(7):1023-31. Unique Identifier : AIDSLINE MED/20245485
- Iida R; Saito K; Yamada K; Basile AS; Sekikawa K; Takemura M; Fujii H; Wada H; Seishima M; Nabeshima T; Department of Neuropsychopharmacology and Hospital Pharmacy,; Nagoya University Graduate School of Medicine, Nagoya 466-8560,; Japan.
- Brain levels of TNF-alpha increase in many inflammatory conditions, including HIV-1 infection, and may contribute to neurodegenerative processes. The paucity of agents that can selectively and potently block TNF-alpha processing or its receptors has led us to investigate the role of TNF-alpha in chronic neurodegenerat
- IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis.
- FASEB J. 2000 May;14(7):948-54. Unique Identifier : AIDSLINE MED/20245476
- Metwali A; Blum AM; Li J; Elliott DE; Weinstock JV; Division of Gastroenterology-Hepatology, Department of Internal; Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
- In murine schistosomiasis, granuloma T cells express VPAC2 mRNA, whereas there is none in splenocytes. This suggests that T cell VPAC2 mRNA is inducible. To address this issue, splenocytes from schistosome-infected mice were incubated with anti-CD3 to induce VPAC2 mRNA, which only appeared when cell cultures also cont
- Cryptosporidium and isospora belli diarrhoea in immunocompromised hosts.
- Indian J Cancer. 1999 Mar;36(1):38-42. Unique Identifier : AIDSLINE MED/20270850
- Ballal M; Prabhu T; Chandran A; Shivananda PG; Department of Microbiology, Kasturba Medical College, Manipal,; Karnataka, India.
- Cryptosporidium and isospora, two of the intestinal coccidian parasites known to be the causative agents of acute diarrhoea in animals, have now emerged as one of the main causes of prolonged life threatening diarrhoea in immunocompromised patients particularly so in patients with AIDS. Between June 1996 and December
- Interaction of merosin (laminin 2) with very late activation antigen-6 is necessary for the survival of CD4+ CD8+ immature thymocytes.
- Immunology. 2000 Apr;99(4):481-8. Unique Identifier : AIDSLINE MED/20253142
- Iwao M; Fukada S; Harada T; Tsujikawa K; Yagita H; Hiramine C; Miyagoe Y; Takeda S; Yamamoto H; Department of Immunology, Graduate School of Pharmaceutical; Sciences, Osaka University, Suita, Osaka, Japan.
- The laminin alpha2-chain is a component of merosin, a member of the laminin family molecules, which is mainly expressed in the basement membranes of striated muscle. It is known that laminin alpha2 gene (lama2) null mutant mice (dy3k/dy3k) exhibit congenital muscular dystrophy (CMD). Because the laminin alpha2-chain i
- Up-regulation of beta-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates.
- Immunology. 2000 Apr;99(4):569-77. Unique Identifier : AIDSLINE MED/20253153
- Lehner T; Wang Y; Cranage M; Tao L; Mitchell E; Bravery C; Doyle C; Pratt K; Hall G; Dennis M; Villinger L; Bergmeier L; Department of Immunobiology, Guy's, King's and St. Thomas'; Hospitals, Medical and Dental Schools, London, UK.
- A non-cognate mechanism of protection against human immunodeficiency virus-1 (HIV-1) infection involves up-regulation of beta-chemokines, which bind and may down-modulate the CCR5 co-receptors, thereby preventing transmission of M-tropic HIV-1. The objective of this investigation was to evaluate this mechanism in vivo
- Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice.
- Immunology. 2000 Apr;99(4):615-24. Unique Identifier : AIDSLINE MED/20253158
- Sakai T; Hisaeda H; Nakano Y; Ishikawa H; Maekawa Y; Ishii K; Nitta Y; Miyazaki J; Himeno K; Department of Parasitology and Immunology, University of; Tokushima School of Medicine, Tokushima, Japan.
- An interleukin-12 (IL-12) expression plasmid was transferred, using a gene gun, to mice infected with Leishmania major or Trypanosoma cruzi. Transfer of the IL-12 gene to susceptible BALB/c mice resulted in regression of lesion size and reduced the number of parasites in draining lymph nodes (LN) at the site of L. maj
- Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.
- Immunol Cell Biol. 2000 Apr;78(2):110-7. Unique Identifier : AIDSLINE MED/20225765
- Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR; Immunology Division, The Walter and Eliza Hall Institute of; Medical Research, Melbourne, Victoria, Australia.
- The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I-restricted, ovalbumin-specific, CD8+ T cells (OT-I cells). These cells are shown to be positively selected in vivo in H-2b C57BL/6 mice and in bm5 mice, which express the Kbm5 mutant molecule. I
- Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?
- Immunol Cell Biol. 2000 Apr;78(2):166-75. Unique Identifier : AIDSLINE MED/20225773
- Rincon M; Conze D; Weiss L; Diehl NL; Fortner KA; Yang D; Flavell RA; Enslen H; Whitmarsh A; Davis RJ; Immunobiology Program, Department of Medicine, University of; Vermont, Burlington, Vermont 05405, USA. mrincon@zoo.uvm.edu
- Mitogen-activated protein (MAP) kinases, which include the extracellular response kinases, p38 and c-Jun amino terminal kinases (JNK), play a significant role in mediating signals triggered by cytokines, growth factors and environmental stress. The JNK and p38 MAP kinases have been involved in growth, differentiation
- Pulmonary manifestations of pediatric HIV infection.
- Indian J Pediatr. 1999 Nov-Dec;66(6):895-904. Unique Identifier : AIDSLINE MED/20258492
- Khare MD; Sharland M; Pediatric Infectious Diseases Unit, St. George's Hospital,; London, United Kingdom.
- Vertically acquired HIV infection is becoming increasingly common in India . The main clinical manifestations of HIV in childhood are growth failure, lymphadenopathy, chronic cough and fever, recurrent pulmonary infections, and persistent diarrhoea. Pulmonary disease is the major cau
- Dermatologic manifestations among human immunodeficiency virus patients in south India.
- Int J Dermatol. 2000 Mar;39(3):192-5. Unique Identifier : AIDSLINE MED/20223446
- Kumarasamy N; Solomon S; Madhivanan P; Ravikumar B; Thyagarajan SP; Yesudian P; YRG Center for AIDS Research and Education, and University of; Madras, Madras, India.
- BACKGROUND: Human immunodeficiency virus (HIV) may be associated with a large number of dermatologic manifestations, which may at times constitute the presenting symptoms. These skin lesions are well delineated in the Western literature, but there is a paucity of information from the southern part of the Indian subcon
- Experience with low-dose thalidomide therapy in chronic discoid lupus erythematosus.
- Int J Dermatol. 2000 Mar;39(3):218-22. Unique Identifier : AIDSLINE MED/20223455
- Kyriakis KP; Kontochristopoulos GJ; Panteleos DN; Department of Dermatology, The West Attica General Hospital and; Leprosy Center, Athens, Greece.
- BACKGROUND: Low-dose thalidomide therapy (median dose 100 mg/day, 50-200 mg/day) in chronic discoid lupus erythematosus was studied with regard to efficacy, tolerance, and toxicity in 22 patients. Intense contraceptive precautions were taken in women patients of childbearing age. METHODS: An open uncontrolled trial wa
- Risk of transmission of blood-borne viral infection in orthopaedic and trauma surgery.
- J Bone Joint Surg Br. 2000 Apr;82(3):313-23. Unique Identifier : AIDSLINE MED/20271269
- Lemaire R; Masson JB; Department of Orthopaedics and Traumatology, University Hospital; (Centre Hospitalier Universitaire), Liege, Belgium.
- Decision-making in HIV prevention community planning: an integrative review.
- J Community Health. 2000 Apr;25(2):95-112. Unique Identifier : AIDSLINE MED/20252178
- Johnson-Masotti AP; Pinkerton SD; Holtgrave DR; Valdiserri RO; Willingham M; Center for AIDS Intervention Research, Department of Psychiatry; and Behavioral Medicine, Medical College of Wisconsin, Milwaukee; 53202, USA.
- Since 1994, the Centers for Disease Control and Prevention has required that the 65 health department grantees that receive funding for HIV prevention interventions engage in a community planning process to involve affected communities in local prevention decision making; to increase the use of epidemiological data to
- A painful cutaneous nodule as the presentation of metastatic transitional cell carcinoma of the renal pelvis.
- J Am Acad Dermatol. 2000 May;42(5 Pt 2):867-8. Unique Identifier : AIDSLINE MED/20231903
- Zirwas MJ; Hunt S; Logan TF; Abernethy JL; Seraly MP; University of Pittsburgh School of Medicine, the Departments of; Internal Medicine and Dermatology, Pittsburgh, PA, USA.
- We report a 43-year-old man with HIV who presented with a painful, vascular-appearing nodule as the initial manifestation of metastasis of a prior transitional cell carcinoma of the renal pelvis. The transitional cell carcinoma had been treated by nephroureterectomy 4 years before the appearance of the nodule. Histopa
- AIDS in Latin America.
- Infect Dis Clin North Am. 2000 Mar;14(1):185-209. Unique Identifier : AIDSLINE MED/20203166
- Cahn P; Belloso WH; Murillo J; Prada-Trujillo G; Department of Infectious Diseases, University of Buenos Aires; School of Medicine, Argentina.
- The epidemic in Latin America has placed an unexpected additional burden on the health care systems and national economies, already weak and affected by severe problems. Specific regional diseases in addition to common opportunistic infections, and particularly the high incidence of TB, produce a different picture com
- Human T-cell lymphotropic virus-I in Latin America.
- Infect Dis Clin North Am. 2000 Mar;14(1):211-39, x-xi. Unique Identifier : AIDSLINE MED/20203167
- Gotuzzo E; Arango C; de Queiroz-Campos A; Isturiz RE; Alexander von Humboldt Institute of Tropical Medicine, Hospital; Nacional Cayetano Heredia, Lima, Peru. egh@upch.edu.pe
- HTLV-1 infection is endemic in several Latin American countries. HTLV-1-associated myelophathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia lymphoma (ATLL) are emerging diseases in the region. Documented risk factors for acquiring the virus include breast-feeding, contaminated blood transfusion, an
- Lack of detection of human herpesvirus (HHV)-8 DNA in lesional skin of German pemphigus vulgaris and pemphigus foliaceus patients [letter]
- J Invest Dermatol. 2000 Apr;114(4):739-41. Unique Identifier : AIDSLINE MED/20213492
- Bezold G; Sander CA; Flaig MJ; Peter RU; Messer G
- The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapy.
- Unique Identifier : AIDSLINE MED/20227747
- Binley JM; Schiller DS; Ortiz GM; Hurley A; Nixon DF; Markowitz MM; Moore JP; The Aaron Diamond AIDS Research Center, The Rockefeller; University, New York, NY 10016, USA. jbinley@adarc.org
- The relationship between human immunodeficiency virus (HIV) type 1 replication and CD4+ T cell function was examined. T lymphocyte proliferation in response to both HIV-1 antigens and recall antigens was measured in HIV-1-infected individuals before and after they received highly active antiretroviral therapy (HAART).
- Strong human immunodeficiency virus (HIV)-specific CD4+ T cell responses in a cohort of chronically infected patients are associated with interruptions in anti-HIV chemotherapy.
- J Infect Dis. 2000 Apr;181(4):1264-72. Unique Identifier : AIDSLINE MED/20227748
- Haslett PA; Nixon DF; Shen Z; Larsson M; Cox WI; Manandhar R; Donahoe SM; Kaplan G; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, NY 10021, USA.; hasletp@rockvax.rockefeller.edu
- Virus-specific CD4+ T-helper cell function is important in controlling human immunodeficiency virus (HIV) infection but is impaired in patients with progressive HIV disease. It has been reported that after highly active antiretroviral therapy (HAART), HIV-specific lymphoproliferative responses remain absent, whereas r
- Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor--sparing highly active antiretroviral therapy.
- J Infect Dis. 2000 Apr;181(4):1273-9. Unique Identifier : AIDSLINE MED/20294194
- Dybul M; Chun TW; Ward DJ; Hertogs K; Larder B; Fox CH; Orenstein JM; Baird BF; Li Y; Green LG; Engel D; Liu S; Mican JM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institute of Health, Bethesda, MD; 20892, USA. mdybul@nih.gov
- Although efavirenz-containing regimens effectively suppress plasma levels of human immunodeficiency virus (HIV) RNA, it is now clear that undetectable plasma viremia may not reflect a lack of viral replication. Because lymphoid tissue is an active site of HIV replication, the lymph node virus burden was analyzed in pe
- Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement.
- J Infect Dis. 2000 Apr;181(4):1280-8. Unique Identifier : AIDSLINE MED/20227749
- Ledergerber B; Flepp M; Boni J; Tomasik Z; Cone RW; Luthy R; Schupbach J; Division of Infectious Diseases, Department of Medicine, Zurich; University Hospital, Zurich, Switzerland.
- Human immunodeficiency virus type 1 (HIV-1) RNA and p24 antigen concentrations were determined in plasma samples from 169 chronically infected patients (median CD4 cell count, 140 cells/microL; range, 0-1500 cells/microL). p24 quantification involved heat-mediated immune complex dissociation and tyramide signal amplif
- Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: A randomized, double-blind, placebo-controlled trial. The AIDS Clinical Trials Group 196/Terry Beirn Community Programs for Clinical Research on AIDS 009 Protocol Team.
- J Infect Dis. 2000 Apr;181(4):1289-97. Unique Identifier : AIDSLINE MED/20227750
- Benson CA; Williams PL; Cohn DL; Becker S; Hojczyk P; Nevin T; Korvick JA; Heifets L; Child CC; Lederman MM; Reichman RC; Powderly WG; Notario GF; Wynne BA; Hafner R; Rush Medical College/Rush-Presbyterian-St. Luke's Medical Center,; Chicago, IL, USA. constance.benson@uchsc.edu
- The efficacy and safety of clarithromycin and rifabutin alone and in combination for prevention of Mycobacterium avium complex (MAC) disease were compared in 1178 patients with AIDS who had
- Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis.
- J Infect Dis. 2000 Apr;181(4):1298-303. Unique Identifier : AIDSLINE MED/20227751
- Hazra R; Lee SH; Maslow JN; Husson RN; Division of Infectious Diseases, Children's Hospital, and; Department of Pediatrics, Harvard Medical School, Boston, MA; 02115, USA.
- Sequence analysis of the ribosomal internal transcribed spacer of 56 Mycobacterium avium complex isolates from pediatric patients with AIDS or lymphadenitis revealed (similar to the situation in adults) that the closely related Mav-B and Mav-A sequevars caused the vast majority of disease. IS1245 restriction fragment-
- Randomized controlled trial of Mycobacterium vaccae immunotherapy in non-human immunodeficiency virus-infected ugandan adults with newly diagnosed pulmonary tuberculosis. The Uganda-Case Western Reserve University Research Collaboration.
- J Infect Dis. 2000 Apr;181(4):1304-12. Unique Identifier : AIDSLINE MED/20227752
- Johnson JL; Kamya RM; Okwera A; Loughlin AM; Nyole S; Hom DL; Wallis RS; Hirsch CS; Wolski K; Foulds J; Mugerwa RD; Ellner JJ; Department of Medicine, Division of Infectious Diseases, Case; Western Reserve University, Tuberculosis Research Unit,; Cleveland, OH 44106-4984, USA. jlj@po.cwru.edu
- Adjunctive immunotherapy with heat-killed Mycobacterium vaccae was studied in a randomized, placebo-controlled trial of 120 non-human immunodeficiency virus-infected adults with newly diagnosed pulmonary tuberculosis. Patients were randomized to a single dose of M. vaccae or placebo 1 week after beginning chemotherapy
- A pneumococcal capsular polysaccharide vaccine induces a repertoire shift with increased VH3 expression in peripheral B cells from human immunodeficiency virus (HIV)-uninfected but not HIV-infected persons.
- J Infect Dis. 2000 Apr;181(4):1313-21. Unique Identifier : AIDSLINE MED/20227753
- Chang Q; Abadi J; Alpert P; Pirofski L; Departments of Microbiology and Immunology, Division of; Infectious Diseases, and Montefiore Hospital and Medical Center,; Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- The molecular mechanism of pneumococcal vaccine failure in human immunodeficiency virus (HIV)-infected persons is not fully understood. A polymerase chain reaction ELISA was used to determine the proportion of peripheral IgG, IgA, and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (V
- A hospital-based prevalence survey of bloodstream infections in febrile patients in Malawi: implications for diagnosis and therapy.
- J Infect Dis. 2000 Apr;181(4):1414-20. Unique Identifier : AIDSLINE MED/20227765
- Archibald LK; McDonald LC; Nwanyanwu O; Kazembe P; Dobbie H; Tokars J; Reller LB; Jarvis WR; Hospital Infections Program, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA. lca6@cdc.gov
- The etiology of bloodstream infections (BSIs) in febrile (> or =37.5 degrees C) adults (> or =18 years old) in one Malawi hospital were determined during August and September 1997. After clinical evaluation, blood was drawn for comprehensive culture, human immunodeficiency virus (H
- Coccidioidomycosis in human immunodeficiency virus-infected persons in Arizona, 1994-1997: incidence, risk factors, and prevention.
- J Infect Dis. 2000 Apr;181(4):1428-34. Unique Identifier : AIDSLINE MED/20227767
- Woods CW; McRill C; Plikaytis BD; Rosenstein NE; Mosley D; Boyd D; England B; Perkins BA; Ampel NM; Hajjeh RA; Epidemic Intelligence Service, Epidemiology Program Office, and; Division of Bacterial and Mycotic Diseases, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, GA 30307, USA.
- From 1 January 1995 through 31 June 1997, 153 cases of coccidioidomycosis in human immunodeficiency virus (HIV)-infected persons were identified in Arizona (incidence, 41/1000 persons living with AIDS). A case-control study was conducted to evaluate risk factors for
- Risk factors for acute symptomatic coccidioidomycosis among elderly persons in Arizona, 1996-1997.
- J Infect Dis. 2000 Apr;181(4):1435-40. Unique Identifier : AIDSLINE MED/20227768
- Leake JA; Mosley DG; England B; Graham JV; Plikaytis BD; Ampel NM; Perkins BA; Hajjeh RA; Epidemic Intelligence Service, Epidemiology Program Office, and; Division of Bacterial and Mycotic Diseases, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.
- Because of the increase in incidence of coccidioidomycosis among the elderly in Arizona between 1990 and 1996, a case-control study was conducted to look at risk factors for disease among these persons. Cases (n=89) were persons aged > or =60 years with laboratory-co
- Human herpesvirus-6 is associated with cytomegalovirus reactivation in liver transplant recipients.
- J Infect Dis. 2000 Apr;181(4):1450-3. Unique Identifier : AIDSLINE MED/20227771
- Humar A; Malkan G; Moussa G; Greig P; Levy G; Mazzulli T; Department of Medicine, Division of Infectious Diseases and; Multi-Organ Transplantation, Toronto General Hospital-University; Health Network, Toronto, Ontario M5G 2C4, Canada.; Atul.Humar@uhn.on.ca
- Human herpesvirus-6 (HHV-6) may be a risk factor for cytomegalovirus ( CMV ) disease in posttransplant patients, possibly through a direct interaction or through a general immunomodulatory effect. To examine this possibility, 8
- Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort Study.
- J Infect Dis. 2000 Apr;181(4):1475-8. Unique Identifier : AIDSLINE MED/20227777
- Hisada M; O'Brien TR; Rosenberg PS; Goedert JJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, MD 20852, USA.; mh280i@nih.gov
- A high human immunodeficiency virus (HIV) load may increase the probability of HIV transmission by sexual contact, but the association of virus load of hepatitis C virus (HCV) with risk of HCV transmission is uncertain. HIV and HCV virus loads were examined in hemophilic men, as were risks of HIV and HCV transmission
- Effect of HIV on thymic function before and after antiretroviral therapy in children.
- J Infect Dis. 2000 Apr;181(4):1479-82. Unique Identifier : AIDSLINE MED/20227778
- Douek DC; Koup RA; McFarland RD; Sullivan JL; Luzuriaga K; Department of Internal Medicine and Microbiology, University of; Texas Southwestern Medical Center, Dallas, TX 75235-9113, USA.; daniel.douek@email.swmed.edu
- Studies were undertaken to investigate the role of the thymus in T cell reconstitution in human immunodeficiency virus (HIV)-infected children treated with antiretroviral therapy. Nine pediatric patients who acquired HIV perinatally were treated with multidrug combinations of antiretroviral agents. Plasma virus load a
- Haptoglobin polymorphism in human immunodeficiency virus infection: Hp0 phenotype limits depletion of CD4 cell counts in HIV-1-seropositive individuals.
- J Infect Dis. 2000 Apr;181(4):1483-5. Unique Identifier : AIDSLINE MED/20227779
- Quaye IK; Brandful J; Ekuban FA; Gyan B; Ankrah NA; Chemical Pathology Unit, Noguchi Memorial Institute for Medical; Research, University of Ghana, Accra, Ghana.; iquaye@noguchi.mimcom.net
- Patients seropositive for human immunodeficiency virus (HIV) type 1 and seronegative control subjects were categorized by their haptoglobin phenotypes, which were determined by electrophoresis of hemoglobin-supplemented plasma samples followed by benzidine staining. The CD4 cell counts, determined by flow cytometry fr
- Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: results of AIDS clinical trials group protocol 853.
- J Infect Dis. 2000 Apr;181(4):1486-90. Unique Identifier : AIDSLINE MED/20227780
- MacArthur RD; Lederman MM; Benson CA; Chernoff MC; MacGregor RR; Spritzler J; Mahon LF; Yen-Lieberman B; Purvis S; Wayne State University, Department of Medicine, Division of; Infectious Diseases, Detroit, MI 48201, USA.; macarthur@intmed.wayne.edu
- Human immunodeficiency virus (HIV) type 1-infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-alpha levels. Blood specimens were obtained fo
- Questions about results reported with potent antiretroviral therapy for human immunodeficiency virus type 1 infection [letter]
- J Infect Dis. 2000 Apr;181(4):1518-20. Unique Identifier : AIDSLINE MED/20227788
- Papadopulos-Eleopulos E; Turner VF; Papadimitriou JM; Alfonso H; Page B; Causer D
- Interleukin 12 and innate molecules for enhanced mucosal immunity.
- Immunol Res. 1999;20(3):207-17. Unique Identifier : AIDSLINE MED/20203905
- Boyaka PN; Lillard JW Jr; McGhee J; The Immunobiology Vaccine Center, The University of Alabama at; Birmingham, 35294-2170, USA.
- Recent strategies for understanding the mechanisms underlying mucosal immune responses and subsequent development of mucosal vaccines for induction of targeted immunity now include cytokines and molecules of innate immunity. These studies have shown that cytokines influencing the development of T helper (Th) cells dif
- The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense.
- Immunol Res. 1999;20(3):219-35. Unique Identifier : AIDSLINE MED/20203906
- Yoshikai Y; Laboratory of Host Defense, Research Institute for Disease for; Mechanism and Control, Nagoya University School of Medicine,; Japan. yoshika@med.nagoya-u.ac.jp
- Intestinal intraepithelial lymphocytes (i-IEL) are located at the basolateral surfaces of intestinal epithelial cells (i-EC) and play important roles in the homeostasis of intestinal microenvironment. i-IEL comprise unique T cell populations including CD4-CD8alphaalpha+ T cells expressing T cell receptor (TCR)alphabet
- Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease.
- Immunol Res. 1999;20(3):237-42. Unique Identifier : AIDSLINE MED/20203907
- Takahashi I; Lijima H; Kishi D; Kiyono H; Department of Mucosal Immunology, Research Institute for; Microbial Diseases, Osaka University, Suita-Osaka, Japan.; snatum@biken.osaka-u.ac.jp
- A population of CD4+ T cells with TCR beta-chain without TCR alpha-chain (CD4+, betabeta T cells) producing Th2-type cytokines increased in the mucosal and peripheral tissues of TCR alpha-chain deficient mice with inflammatory bowel disease (IBD). Analysis of TCR-beta immunoprecipitates by two-dimensional electrophore
- New gut associated lymphoid tissue "cryptopatches" breed murine intestinal intraepithelial T cell precursors.
- Immunol Res. 1999;20(3):243-50. Unique Identifier : AIDSLINE MED/20203908
- Ishikawa H; Saito H; Suzuki K; Oida T; Kanamori Y; Department of Microbiology, Keio University School of Medicine,; Tokyo, Japan. ishikawa@sun.microb.med.keio.ac.jp
- Numerous mouse intraepithelial T cells (IEL) bearing either TCR-alphabeta or TCR-gammadelta have been shown to develop somewhere in the intestinal mucosa without passing through the thymus. However, just where these T cells develop has been much less clear and has remained an open question to date. In an effort to inv
- The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity.
- J Leukoc Biol. 2000 May;67(5):607-14. Unique Identifier : AIDSLINE MED/20269136
- Clarke SR; Howard Hughes Medical Institute and Department of Immunology,; University of Washington School of Medicine, Seattle 98195-7370,; USA. clarkes@u.washington.edu
- Control of virus infections and eradication of tumors usually involves the lytic activity of CD8+ cytotoxic T lymphocytes (CTLs). The induction of effective CTL immunity relies on several factors, one of the most important of which is CD4+ T cell help. Numerous studies have demonstrated the dependence of CTL priming o
- CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons [see comments]
- J Exp Med. 2000 May 1;191(9):1459-66. Unique Identifier : AIDSLINE MED/20253233
- Liu T; Khanna KM; Chen X; Fink DJ; Hendricks RL; Department of Ophthalmology, University of Pittsburgh, School of; Medicine, Pittsburgh, Pennsylvania 15213, USA.
- Recurrent herpes simplex virus type 1 (HSV-1) disease usually results from reactivation of latent virus in sensory neurons and transmission to peripheral sites. Therefore, defining the mechanisms that maintain HSV-1 in a latent state in sensory neurons may provide new approaches to reducing susceptibility to recurrent
- Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses.
- J Exp Med. 2000 May 1;191(9):1605-10. Unique Identifier : AIDSLINE MED/20253246
- He J; Gurunathan S; Iwasaki A; Ash-Shaheed B; Kelsall BL; Immune Cell Interaction Unit, Mucosal Immunity Section,; Laboratory of Clinical Investigation, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892, USA.
- We explored the role of Gi protein signaling in the regulation of interleukin (IL)-12 production and T helper cell type 1 (Th1) T cell differentiation. In initial studies, we showed that treatment of normal mice with pertussis toxin (PT), which inhibits Gi protein signaling, enhanced the capacity of splenocytes to pro
- A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma.
- J Exp Med. 2000 May 1;191(9):1617-24. Unique Identifier : AIDSLINE GENBANK/AF164963
- Moreau-Aubry A; Le Guiner S; Labarriere N; Gesnel MC; Jotereau F; Breathnach R; Institut National de la Sante et de la Recherche Medicale; (INSERM) U463, 44093 Nantes cedex 01, France.
- The M88.7 T cell clone recognizes an antigen presented by HLA B*1302 on the melanoma cell line M88. A cDNA encoding this antigen (NA88-A) was isolated using a library transfection approach. Analysis of the genomic gene s sequence identified it is a processed pseudogene, derived from a retrotranscript of mRNA coding fo
- HTLV-1 and HIV infections of the central nervous system in tropical areas.
- J Neurol Neurosurg Psychiatry. 2000 May;68(5):550-7. Unique Identifier : AIDSLINE MED/20229910
- Cabre P; Smadja D; Cabie A; Newton CR; Department of Neurology, University Hospital of Fort-de-France,; Martinique, French West Indies.
- Global 3D-QSAR methods: MS-WHIM and autocorrelation.
- J Comput Aided Mol Des. 2000 Mar;14(3):293-306. Unique Identifier : AIDSLINE MED/20219970
- Gancia E; Bravi G; Mascagni P; Zaliani A; Italfarmaco Research Centre, Milan, Italy.; emanuelagancia@chiroscience.com
- The recently proposed MS-WHIM indices, a set of theoretical descriptors containing information about size, shape and electrostatic distribution of a molecule, have been further investigated. The main objectives of this work were: (i) to confirm the descriptive power of MS-WHIM in modelling specific biological interact
- Use of cultured cerebral capillary endothelial cells in modeling the central nervous system availability of 2',3'-dideoxyinosine.
- J Pharm Sci. 2000 Mar;89(3):322-35. Unique Identifier : AIDSLINE MED/20173669
- Johnson MD; Anderson BD; Department of Pharmaceutics and Pharmaceutical Chemistry,; University of Utah, Salt Lake City, Utah 84112, USA.
- The biochemical and physiological mechanisms responsible for the limited central nervous system (CNS) uptake of dideoxynucleoside reverse transcriptase inhibitors currently used to treat HIV-1 infection in humans are poorly understood. In vitro models of the blood-brain barrier (BBB) offer an attractive alternative to
- Africa needs more aid, new partnerships to fight malaria [news]
- JAMA. 2000 May 17;283(19):2510, 2513. Unique Identifier : AIDSLINE MED/20275996
- Voelker R
- From the Centers for Disease Control and Prevention. HIV-related tuberculosis in a transgender Network--Baltimore, Maryland, and New York City Area, 1998-2000.
- JAMA. 2000 May 17;283(19):2515-6. Unique Identifier : AIDSLINE MED/20294196
- Elevated liver enzymes following initiation of antiretroviral therapy [letter; comment]
- JAMA. 2000 May 17;283(19):2526-7. Unique Identifier : AIDSLINE MED/20276013
- Velasco M; Guijarro C
- Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: a collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Concerted Action on SeroConversion to AIDS and Death in Europe.
- Lancet. 2000 Apr 1;355(9210):1131-7. Unique Identifier : AIDSLINE MED/20250014
- BACKGROUND: We used data from Europe, North America, and Australia to assess the effect of exposure category on the AIDS incubation period and HIV-1 survival and whether the effect of age at seroconversion varies with exposure category and with time since seroconversion. METHODS
- Survival after introduction of HAART in people with known duration of HIV-1 infection. The CASCADE Collaboration. Concerted Action on SeroConversion to AIDS and Death in Europe [letter]
- Unique Identifier : AIDSLINE MED/20250022
- We compared survival from HIV-1 seroconversion before and during the periods of highly-active antiretroviral therapy (HAART).
- Questioning of HIV theory of AIDS causes dismay in South Africa [news]
- Lancet. 2000 Apr 1;355(9210):1167. Unique Identifier : AIDSLINE MED/20250030
- Baleta A
- Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy.
- Neurology. 2000 May 9;54(9):1856-9. Unique Identifier : AIDSLINE MED/20264465
- d'Arminio Monforte A; Duca PG; Vago L; Grassi MP; Moroni M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy. a-darm1@mailserver.unimi.it
- The authors enrolled 1,029 patients with CD4 counts
- Predictive markers of clinical outcome in vertically HIV-1-infected infants. A prospective longitudinal study.
- Pediatr Res. 2000 Apr;47(4 Pt 1):509-15. Unique Identifier : AIDSLINE MED/20220909
- Resino S; Gurbindo D; Cano JM; Sanchez-Ramon S; Muoz-Fernandez MA; Division of Immunology, Hospital General Universitario Gregorio; Maranon, Madrid, Spain.
- We have investigated the relationship between disease progression and several immunologic and virologic markers of HIV infection. Plasma samples from infants born to HIV-1-infected mothers were collected at birth and at 1, 2, 4, 6, 9, 12, 15, and 18 mo of age and subsequently were assayed every 6 mo for viral load, vi
- [Use of urinary beta-hexosaminidase for diagnosing alcoholism in persons with opiate dependency in a methadone substitution program]
- Psychiatr Pol. 1999 Mar-Apr;33(2):215-23. Unique Identifier : AIDSLINE MED/20247950
- Taracha E; Habrat B; Chmielewska K; Baran H; Szukalski B; Zakladu Biochemii IPiN w Warszawie.
- Usefulness of urinary beta-hexosaminidase determinations in patients on methadone substitution to pinpoint cases of alcohol abuse was studied. It was found that methadone, illegal drugs and HIV seropositivity had no effect upon the activity of this enzyme. The enzyme activity was significantly higher in patients who a
- Human immunodeficiency virus bDNA assay for pediatric cases.
- Rev Argent Microbiol. 2000 Jan-Mar;32(1):33-8. Unique Identifier : AIDSLINE MED/20247665
- Avila MM; Liberatore D; Martinez Peralta L; Biglione M; Libonatti O; Coll Cardenas P; Hodara VL; Departamento de Microbiologia, Facultad de Medicina, Universidad; de Buenos Aires, Piso, Argentina.
- Techniques to quantify plasma HIV-1 RNA viral load (VL) are commercially available, and they are adequate for monitoring adults infected by HIV and treated with antiretroviral drugs. Little experience on HIV VL has been reported in pediatric cases. In Argentina , the evaluation o
- [Use of polymerase chain reaction in medical diagnosis]
- Przegl Lek. 1999;56(11):723-34. Unique Identifier : AIDSLINE MED/20260380
- Swiat A; Stepien E; Andres J; Dziatkowiak A; Katedry Anestezjologii i Intensywnej Terapii, Collegium Medicum,; Uniwersytetu Jagiellonskiego w Krakowie.
- Principles of the polymerase chain reaction (PCR) and its modifications are discussed: reverse transcription-PCR (RT-PCR), nested PCR, restriction fragment length polymorphism-PCR (RFLP-PCR). Different methods of the PCR products detection used in routine diagnostics and research are presented: electrophoresis and chr
- [Stevens-Johnson syndrome due to nevirapine (letter)]
- Rev Clin Esp. 2000 Mar;200(3):179-80. Unique Identifier : AIDSLINE MED/20264892
- Garcia Fernandez D; Garcia-Patos Briones V; Mollet Sanchez J; Castells Rodellas A
- [AIDS and anesthesia]
- Rev Esp Anestesiol Reanim. 2000 Mar;47(3):114-25, 129. Unique Identifier : AIDSLINE MED/20260156
- Una Orejon R; Ureta Tolsada P; Una Orejon S; Maseda Garrido E; Criado Jimenez A; Servicio de Anestesiologia y Reanimacion, Hospital General La; Paz, Madrid.
- AIDS concerns anaesthetic practice for various reasons. First, this syndrome can affect different organs that have anaesthetic implications. Second, drugs usually taken by the patient can interact with anaesthetic agents. And last, the risk of infection for health workers must be taken into account, as well as the pro
- Characterization of reactivation of cytomegalovirus retinitis in patients healed after treatment with highly active antiretroviral therapy.
- Retina. 2000;20(2):151-5. Unique Identifier : AIDSLINE MED/20244533
- Song MK; Karavellas MP; MacDonald JC; Plummer DJ; Freeman WR; Shiley Eye Center, University of California, San Diego; 92093-0946, USA.
- PURPOSE: To delineate the immune parameters associated with reactivation of cytomegalovirus ( CMV ) retinitis in patients for whom highly active antiretroviral therapy (HAART) was not successful. METHODS: Prospective, longitudi
- Exudative retinal detachment and retinitis associated with acquired syphilitic uveitis.
- Retina. 2000;20(2):190-4. Unique Identifier : AIDSLINE MED/20244539
- Jumper JM; Machemer R; Gallemore RP; Jaffe GJ; Department of Ophthalmology, Wilford Hall Medical Center,; Lackland Air Force Base, Texas, USA.
- PURPOSE: To describe three cases of exudative retinal detachment and focal retinitis associated with acquired syphilitic uveitis. METHODS: Three patients who were referred for evaluation of uveitis were examined. Slit-lamp examination, ophthalmoscopy, B-scan ultrasonography, fundus photography, and fluorescein angiogr
- Participatory diagramming as a means to improve communication about sex in rural Zimbabwe: a pilot study.
- Soc Sci Med. 2000 Jun;50(12):1723-41. Unique Identifier : AIDSLINE MED/20256186
- Kesby M; School of Geography and Geosciences, University of St Andrews,; Fife, Scotland, UK. mike.kesby@st-and.ac.uk
- It is increasingly recognised that unequal gender relations and poor communication between men and women about sexual matters, play a central role in the rapid transmission of HIV in sub-Saharan Africa. Analysis of how communication might practically be improved remains a critical area for investigation however. To th
- Impact of natural chemokine receptor polymorphisms on perinatal transmission of human immunodeficiency virus type 1.
- Teratology. 2000 May;61(5):387-90. Unique Identifier : AIDSLINE MED/20242079
- Kostrikis LG; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA. lkostrik@adarc.org
- Role of the placenta in fetal HIV infection.
- Teratology. 2000 May;61(5):391-4. Unique Identifier : AIDSLINE MED/20242080
- Miller RK; Polliotti BM; Laughlin T; Gnall S; Iida S; Carneiro M; Lord K; Ding Y; Sheikh AU; Departments of Obstetrics and Gynecology and of Environmental; Medicine, University of Rochester, School of Medicine and; Dentistry, Rochester, New York 14642-8668, USA.; richardk_miller@urmc.rochester.edu
- Follow-up of children exposed to perinatal antiretrovirals.
- Teratology. 2000 May;61(5):395-6. Unique Identifier : AIDSLINE MED/20242081
- Fowler MG; MCTPASS/Epidemiology Branch, Division of HIV/AIDS-SE, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.
- Potential toxicities of HIV therapeutics in the developing infant.
- Teratology. 2000 May;61(5):397-8. Unique Identifier : AIDSLINE MED/20242082
- Slikker W Jr; Olivero OA; Patterson TA; Poirier MC; Division of Neurotoxicology, NCTR, Food and Drug Administration,; Jefferson, Arkansas 72079-9502, USA. wslikker@nctr.fda.gov
- Competition by allelopathy proceeds in traveling waves: colicin-immune strain aids colicin-sensitive strain.
- Theor Popul Biol. 2000 Mar;57(2):131-44. Unique Identifier : AIDSLINE MED/20255631
- Nakamaru M; Iwasa Y; Department of Biology, Kyushu University, CREST, Japan Science; and Technology Corporation, Fukuoka, 812-8581, Japan.
- Producing toxic chemicals to suppress both the growth and survivorship of local competitors is called allelopathy; some strains of the bacteria Escherichia coli produce a toxin (named colicin) which may kill colicin-sensitive neighbors while they themselves are immune. In a previous paper, the competitive outcome betw
- Fusion mediated by the HIV-1 envelope protein.
- Subcell Biochem. 2000;34:457-81. Unique Identifier : AIDSLINE MED/20268386
- McManus CM; Doms RW; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.
- Prevalence, patterns, and course of past hepatitis B virus infection in intravenous drug users with HIV-1 infection.
- Am J Gastroenterol. 2000 May;95(5):1316-22. Unique Identifier : AIDSLINE MED/20269483
- Rodriguez-Mendez ML; Gonzalez-Quintela A; Aguilera A; Barrio E; Department of Internal Medicine, Complejo Hospitalario; Universitario, Santiago de Compostela, Spain.
- OBJECTIVE: Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) share common routes of transmission. Therefore, markers of either active or past HBV infection are present in many HIV-infected patients, particularly in intravenous drug users (IDUs). The aim of this study was to analyze the serological pattern
- Treatment of the wrong disease with the right medication: a case of generalized leishmaniasis involving the liver and the gastrointestinal tract [letter]
- Am J Gastroenterol. 2000 May;95(5):1377. Unique Identifier : AIDSLINE MED/20269507
- Olofinlade O; Cacciarelli A
- HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype.
- Am J Hematol. 2000 May;64(1):64-6. Unique Identifier : AIDSLINE MED/20273212
- Nakase K; Hasegawa M; Tsuji K; Ikeda T; Tamaki S; Tanigawa M; Miyanishi E; Shiku H; Department of Internal Medicine, Saiseikai Matsusaka Hospital,; Mie, Japan.
- We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reactio
- Polycythemia in patients infected with human immunodeficiency virus-1 [letter]
- Am J Hematol. 2000 May;64(1):80-1. Unique Identifier : AIDSLINE MED/20273220
- Koduri PR; Sherer R; Teter C
- Prevalence of HIV-associated nephropathy in autopsies of HIV-infected patients.
- Am J Kidney Dis. 2000 May;35(5):884-8. Unique Identifier : AIDSLINE MED/20255117
- Shahinian V; Rajaraman S; Borucki M; Grady J; Hollander WM; Ahuja TS; Department of Medicine, University of Texas Medical Branch,; Galveston, TX 77555, USA.
- Previous studies have reported that approximately 10% of the patients with human immunodeficiency virus (HIV) infection develop HIV-associated nephropathy (HIVAN). However, over the last decade, morbidity and mortality as a result of HIV-1 infection has remarkably decreased with the availability of potent new antiretr
- Evaluation of rapid diagnostic tests for the detection of human immunodeficiency virus types 1 and 2, hepatitis B surface antigen, and syphilis in Ho Chi Minh City, Vietnam.
- Am J Trop Med Hyg. 2000 Feb;62(2):301-9. Unique Identifier : AIDSLINE MED/20271597
- Lien TX; Tien NT; Chanpong GF; Cuc CT; Yen VT; Soderquist R; Laras K; Corwin A; Pasteur Institute, Ho Chi Minh City, Vietnam.
- An evaluation of three new rapid diagnostic test kits for human immunodeficiency virus types 1 and 2 (HIV-1/2), hepatitis B surface antigen (HBsAg), and syphilis involved a two-phase comparison of rapid diagnostic assays using prospectively collected from hospitals and clinics in Ho Chi Minh City,
- Trimethoprim-sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospara belli and Cyclospora cayetanensis infection in HIV-infected patients. A randomized, controlled trial.
- Ann Intern Med. 2000 Jun 6;132(11):885-8. Unique Identifier : AIDSLINE MED/20279646
- Verdier RI; Fitzgerald DW; Johnson WD Jr; Pape JW; Cornell University Medical College, New York, New York 10021,; USA.
- BACKGROUND: In developing countries, Isospora belli and Cyclospora cayetanensis frequently cause chronic diarrhea in HIV-infected patients. OBJECTIVE: To compare 1 week of trimethoprim-sulfamethoxazole treatment and 1 week of ciprofloxacin treatment in HIV-infected patients with chronic diarrhea caused by I. belli and
- Name-based surveillance for HIV-infected persons [letter]
- Ann Intern Med. 2000 Jun 6;132(11):922-3. Unique Identifier : AIDSLINE MED/20279655
- Brewer DD; Potterat JJ
- Ethical aspects of reproduction in the next century.
- Ann N Y Acad Sci. 2000;900:357-74. Unique Identifier : AIDSLINE MED/20278366
- Fasouliotis SJ; Schenker JG; Department of Obstetrics and Gynecology, Hebrew University,; Hadassah Medical Center, Jerusalem, Israel.
- Doubtless, the technological advancements achieved in the current century in the area of young women s reproductive health care have also led to the evolution of very important ethical issues that will have to be dealt with in the coming century. Abortion, perhaps the most controversial issue of all, continues to rais
- Treatment of recurrent Kaposi's sarcoma of an AIDS patient with weekly paclitaxel.
- Anticancer Res. 2000 Mar-Apr;20(2B):1159-61. Unique Identifier : AIDSLINE MED/20270711
- Hsu CH; Chen MY; Cheng AL; Department of Oncology, National Taiwan University Hospital,; Taipei.
- Paclitaxel was recently recognized as an active chemotherapeutic agent for acquired immunodeficiency syndrome (AIDS)-associated Kaposi s sarcoma (KS). However, the best way to administer paclitaxel in AIDS-KS patients remains unknown. Herein, we reported an AIDS-associated KS patient whose disease progressed on the fi
- Saliva cannot destroy HIV-infected milk or semen cells [news]
- AORN J. 2000 Mar;71(3):480. Unique Identifier : AIDSLINE MED/20292037
- Moisturizing alcohol hand gels for surgical hand preparation.
- AORN J. 2000 Mar;71(3):584-7, 589-90, 592 passim. Unique Identifier : AIDSLINE MED/20200881
- Jones RD; Jampani H; Mulberry G; Rizer RL; Scientific & Regulatory Consultants, Inc., Columbia City, Ind.,; USA.
- With the use of novel formulary technology, unique moisturizing hand gels have been developed that offer significant advantages in perioperative and other health care settings. These advantages include the time-saving capabilities of a waterless formulation, the persistence and effectiveness of a surgical scrub, and t
- [Perirenal spontaneous hematoma in HIV(+)-patient in pelvic kidney]
- Arch Esp Urol. 2000 Mar;53(2):161-3. Unique Identifier : AIDSLINE MED/20262267
- Garcia Panos JM; Jimenez Leiro JF; Sampietro Crespo A; Bolano N; Olle Carreras J; Servicio de Urologia, Hospital Virgen de la Salud, Toledo,; Espana.
- OBJECTIVE: A case of spontaneous perirenal hematoma in pelvic kidney in an HIV(+) patient is described. METHODS: The literature on the etiology of spontaneous perirenal hematoma in pelvic kidney is reviewed, with special reference to the three cases reported in HIV(+) patients. RESULTS/CONCLUSION: The patient presente
- Can polymerase chain reaction help distinguish benign from malignant lymphoid aggregates in bone marrow aspirates?
- Arch Pathol Lab Med. 2000 Apr;124(4):511-5. Unique Identifier : AIDSLINE MED/20211153
- Ben-Ezra J; Hazelgrove K; Ferreira-Gonzalez A; Garrett CT; Department of Pathology, Medical College of Virginia Campus of; Virginia Commonwealth University, Richmond, VA 23298-0250, USA.
- OBJECTIVE: Although morphologic and immunologic clues are helpful in distinguishing benign from malignant lymphoid aggregates in bone marrow biopsies, there remain some cases in which it is not possible to arrive at a definitive diagnosis. Since the malignant aggregates are monoclonal B-cell proliferations, we sought
- Laboratory abnormalities in former blood donors seropositive for human T-lymphotropic virus types 1 and 2: a prospective analysis.
- Arch Pathol Lab Med. 2000 Apr;124(4):550-5. Unique Identifier : AIDSLINE MED/20211160
- Glynn SA; Murphy EL; Wright DJ; Sacher RA; Fridey J; Schreiber GB; Westat Inc, Rockville, MD 20850, USA.
- CONTEXT: The human T-lymphotropic viruses types 1 and 2 (HTLV-1 and HTLV-2) are highly prevalent among injection drug users in the United States . However, the clinical course of infection has not been well characterized. OBJECTIVE: To understand HTLV-1-and HTLV-2-associated laboratory
- Multiple crusted cutaneous plaques in a cat.
- Aust Vet J. 1999 Jun;77(6):360, 367-8. Unique Identifier : AIDSLINE MED/20272278
- Foster SF; Charles JA; Swinney GR; Malik R; Department of Veterinary Clinical Sciences, University of Sydney,; New South Wales.
- HIV postexposure prophylaxis for children and adolescents.
- Unique Identifier : AIDSLINE MED/20289497
- Babl FE; Cooper ER; Damon B; Louie T; Kharasch S; Harris JA
- HIV postexposure prophylaxis (PEP) is now a well-established part of the management of health care workers after occupational exposures to HIV. Use of PEP for adults exposed to HIV after sexual contact or injection drug use in nonoccupational settings remains controversial with limited data available. There is even le
- The occupational hazards of emergency physicians.
- Unique Identifier : AIDSLINE MED/20289499
- Dorevitch S; Forst L; Department of Emergency Medicine, Lake Forest Hospital, IL, USA.; sdorevit@uic.edu
- Emergency physicians are exposed to a variety of occupational hazards. Among these are infectious diseases, such the human immunodeficiency virus, hepatitis B and C viruses, and tuberculosis. Hepatitis G virus is transmissible but may not be a cause of illness. The likelihood of being exposed to these agents appears t
- Effects of paternal lymphocyte immunization on peripheral Th1/Th2 balance and TCR V beta and V gamma repertoire usage of patients with recurrent spontaneous abortions.
- Am J Reprod Immunol. 2000 Feb;43(2):107-15. Unique Identifier : AIDSLINE MED/20197649
- Hayakawa S; Karasaki-Suzuki M; Itoh T; Ishii M; Kanaeda T; Nagai N; Takahashi-Yamamoto N; Tochigi M; Chishima F; Fujii TK; Oyama J; Kitanaka S; Satoh K; Department of Obstetrics and Gynaecology, Nihon University School; of Medicine, Tokyo, Japan. jag06-422@nifty.ne.jp
- PROBLEM: The mechanism of immunotherapy for patients with recurrent spontaneous abortions is not well understood. In order to investigate the suppressor mechanism of paternal lymphocyte immunization, we examined peripheral blood lymphocyte subpopulations and the repertoire of T-cell receptor (TCR) gene segments. METHO
- [Nasal leishmaniasis in an HIV-positive patient]
- Acta Otorrinolaringol Esp. 2000 Mar;51(2):169-73. Unique Identifier : AIDSLINE MED/20263582
- Grasa JM; Lorente J; Crego F; Naches S; Subirana FX; Calderon JR; Pollan C; Encarnacion LF; Quesada P; Servicio de ORL, Hospital General Universitario Vall d'Hebron,; Barcelona, Espana. 32470jpg@comb.es
- Leishmania is currently one of the most clinically important protozoa in otorhinolaryngology. Mediterranean countries, including Spain , have endemic HIV and L. infantum. Dogs are the most important Leishmania reservoir. Leishmaniasis is transmitted basically by the bite of infected
- Molecular epidemiology of HIV type 1 in a rural community in southwest Uganda.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):393-401. Unique Identifier : AIDSLINE +
- Kaleebu P; Whitworth J; Hamilton L; Rutebemberwa A; Lyagoba F; Morgan D; Duffield M; Biryahwaho B; Magambo B; Oram J; Medical Research Council Programme for AIDS in Uganda/Uganda; Virus Research Institute, Entebbe. mrc@starcom.co.ug
- The molecular epidemiology of a population-based cohort in a cluster of 15 villages in southwestern Uganda was investigated by sequencing part of the p24 gag gene and performing heteroduplex mobility assays (HMAs) of the V3 region of the env gene. Sequence and HMA data, obtained fo
- Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):403-13. Unique Identifier : AIDSLINE MED/20233480
- Markert ML; Hicks CB; Bartlett JA; Harmon JL; Hale LP; Greenberg ML; Ferrari G; Ottinger J; Boeck A; Kloster AL; McLaughlin TM; Bleich KB; Ungerleider RM; Lyerly HK; Wilkinson WE; Rousseau FS; Heath-Chiozzi ME; Leonard JM; Haase AT; Shaw GM; Bucy RP; Douek DC; Koup RA; Haynes BF; Bolognesi DP; Weinhold KJ; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina 27710, USA. marke001@mc.duke.edu
- The purpose of this study was to determine whether thymic transplantation in addition to highly active antiretroviral therapy (HAART) will restore T cell function in HIV infection. Eight treatment-naive HIV-infected patients with CD4+ T cell counts of 200-500/mm3 were randomized into thymic transplantation and control
- Effect of food and pharmacokinetic variability on didanosine systemic exposure in HIV-infected children. Pediatric AIDS Clinical Trials Group Protocol 144 Study Team.
- Unique Identifier : AIDSLINE MED/20233481
- Stevens RC; Rodman JH; Yong FH; Carey V; Knupp CA; Frenkel LM
- The effect of food on didanosine bioavailability and interpatient pharmacokinetic variability was examined in children infected with human immunodeficiency virus type 1 (HIV-1). Didanosine pharmacokinetics were determined during fasting and fed conditions in HIV-infected children enrolled in the Pediatric AIDS Clinica
- Quantitative study of beta1-integrin expression and fibronectin interaction profile of T lymphocytes in vitro infected with HIV.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):423-33. Unique Identifier : AIDSLINE MED/20233482
- Leblond V; Legendre C; Gras G; Dereuddre-Bosquet N; Lafuma C; Dormont D; CEA, Service de Neurovirologie, DSV/DRM, CRSSA, IPSC, Fontenay; aux Roses, France.
- Cell-extracellular matrix interactions, regulated in part by beta1-integrins, play a key role in the recirculation of T lymphocytes and tissue infiltration in inflammatory and immune responses. HIV infection may affect CD4+ T cell adhesion, and the trafficking and migration of these cells, which are crucial for foreig
- Mycobacterium avium induces HIV upregulation through mechanisms independent of cytokine induction.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):435-40. Unique Identifier : AIDSLINE MED/20233483
- Ghassemi M; Asadi FK; Andersen BR; Novak RM; Department of Medicine, University of Illinois, Chicago 60612,; USA. Ghassemi@uic.edu
- Mycobacterium avium complex (MAC) can induce upregulation of HIV. To investigate the underlying mechanisms, the effect of MAC-induced cytokines on HIV replication was first studied. Semiquantitative RT-PCR, followed by Northern blot analysis, revealed that mRNA encoding IL-6 and TNF-alpha was induced by MAC. However,
- nef/long terminal repeat quasispecies from HIV type 1-infected Mexican patients with different progression patterns and their pathogenesis in hu-PBL-SCID mice.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):441-52. Unique Identifier : AIDSLINE MED/20233484
- Gomez-Roman VR; Vazquez JA; del Carmen Basualdo M; Estrada FJ; Ramos-Kuri M; Soler C; Unidad de Investigacion en Retrovirus Humanos, Instituto de; Investigaciones Biomedicas, Universidad Nacional Autonoma de; Mexico, DF Mexico.
- To examine the genetic features of the long terminal repeat (LTR) derived from six HIV-1-infected individuals enrolled in the Mexico City Cohort, we cloned and sequenced a 505-bp fragment of the proviral LTR from their peripheral blood mononuclear cells (PBMCs). All patients harbored HIV-1 LTR quasispecies correspondi
- Human immunodeficiency virus type 1 can infect human retinal pigment epithelial cells in culture and alter the ability of the cells to phagocytose rod outer segment membranes.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):453-63. Unique Identifier : AIDSLINE MED/20233485
- Canki M; Sparrow JR; Chao W; Potash MJ; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, Columbia University, New York, New York 10019, USA.
- Human immunodeficiency virus type 1 (HIV-1) has been found in the vitreous of persons with AIDS. Here we investigated the susceptibility of human retinal pigment epithelial (RPE) cells to HIV-1 infection in culture and the effects of HIV-1 on the phagocytic function of the RPE. We found that 10 of 11 populations of RP
- Construction of chimeric simian and human immunodeficiency viruses that produce interleukin 12.
- Unique Identifier : AIDSLINE MED/20233486
- Kuwata T; Miura T; Haga T; Kozyrev I; Hayami M
- Chimeric simian and human immunodeficiency viruses (SHIVs) are useful for evaluating vaccine candidates against HIV-1 and for investigating the pathogenesis of HIV-1 in vivo. In addition, SHIVs are candidates for a vaccine against HIV-1 because attenuated SHIVs can induce long-lasting anti-HIV-1 Env humoral and cell-m
- HERV-IP-T47D, a novel type C-related human endogenous retroviral sequence derived from T47D particles.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):471-80. Unique Identifier : AIDSLINE GENBANK/AF087913
- Seifarth W; Baust C; Schon U; Reichert A; Hehlmann R; Leib-Mosch C; Medical Clinic III, Faculty of Clinical Medicine Mannheim,; University of Heidelberg, Germany. seifarth@rumms.uni-manheim.de
- A new type C retrovirus-related endogenous pol sequence (ERV-FTD) found to be occasionally copackaged in retrovirus-like particles released by the human mammary carcinoma cell line T47D was used to screen a human genomic library (Seifarth W, Skladny H, Krieg-Schneider F, Reichert A, Hehlmann R, and Leib-Mosch C: J Vir
- Mice transgenic for monocyte-tropic HIV type 1 produce infectious virus and display plasma viremia: a new in vivo system for studying the postintegration phase of HIV replication.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):481-92. Unique Identifier : AIDSLINE MED/20233488
- Browning Paul J; Wang EJ; Pettoello-Mantovani M; Raker C; Yurasov S; Goldstein MM; Horner JW; Chan J; Goldstein H; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, New York 10461, USA.
- To generate an in vivo system for investigating the postintegration phase of HIV-1 replication, mouse lines transgenic for a full-length infectious proviral clone of a monocyte-tropic HIV-1 isolate, HIV-1JR-CSF, were constructed. Leukocytes from two independent JR-CSF transgenic mouse lines produced HIV-1 that infecte
- Identification of HIV type 1 intersubtype recombinants in South Africa using env and gag heteroduplex mobility assays.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):493-7. Unique Identifier : AIDSLINE GENBANK/AF159878
- Bredell H; Hunt G; Morgan B; Tiemessen CT; Martin DJ; Morris L; AIDS Virus Research Unit, National Institute for Virology,; Johannesburg, South Africa.
- Subtype-specific sequence variation of the HIV type 1 long terminal repeat and primer-binding site.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):499-504. Unique Identifier : AIDSLINE +
- De Baar MP; De Ronde A; Berkhout B; Cornelissen M; Van Der Horn KH; Van Der Schoot AM; De Wolf F; Lukashov VV; Goudsmit J; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands. m.p.debaar@amc.uva.nl
- We studied sequence differences in regulatory elements of the long terminal repeat (LTR) and primer-binding site (PBS) among various human immunodeficiency virus type 1 (HIV-1) subtypes. Phylogenetic sequence analysis of a fragment of 729 base pairs (bp) covering the Gag-coding region for half of p24 and all of p17 re
- Recombinant human immunodeficiency viruses type 1 circulating in Spain.
- AIDS Res Hum Retroviruses. 2000 Mar 20;16(5):505-11. Unique Identifier : AIDSLINE +
- Holguin A; Rodes B; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- The protease, reverse transcriptase (RT), and envelope (env) genes of human immunodeficiency virus type 1 (HIV-1) clinical isolates from 13 immigrants (mainly of African origin) living in Spain were examined. Phylogenetic analyses were performed, taking as reference a panel of 25 HI
- Genetic subtypes of HIV type 1 in Hungary.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):513-6. Unique Identifier : AIDSLINE GENBANK/AJ245472
- Mezei M; Balog K; Takacs M; Toth G; Gyuris A; Segesdi J; Bakos A; Vodros D; Banhegyi D; Berencsi G; Minarovits J; Microbiological Research Group, National Center for Epidemiology,; Budapest, Hungary.
- We examined the diversity of HIV-1 subtypes in 11 adults from Hungary , using the heteroduplex mobility assay (HMA) and DNA sequencing. HMA results showed that HIV-1 gp120 sequences from 10 patients were of subtype B, whereas 1 patie
- Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):517-28. Unique Identifier : AIDSLINE MED/20236900
- Balzarini J; De Clercq E; Carbonez A; Burt V; Kleim JP; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. ian.balzarini@rega.kuleuven.ac.be
- The novel quinoxaline GW420867X has been combined with a variety of nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1(IIIB)-infected CEM cell cultures. Whereas the antiviral efficacy of combinations of GW420867X with the NRTIs lamivudine (
- Baseline HIV type 1 genotypic resistance to a newly added nucleoside analog is predictive of virologic failure of the new therapy.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):529-37. Unique Identifier : AIDSLINE MED/20236901
- Van Vaerenbergh K; Van Laethem K; Van Wijngaerden E; Schmit JC; Schneider F; Ruiz L; Clotet B; Verhofstede C; Van Wanzeele F; Muyldermans G; Simons P; Stuyver L; Hermans P; Evans C; De Clercq E; Desmyter J; Vandamme AM; Rega Institute and University Hospitals, Katholieke Universiteit; Leuven, Belgium.
- We evaluated the predictive value of baseline HIV-1 genotypic resistance mutations for failure of a nucleoside reverse transcriptase inhibitor (NRTI) containing therapy. The change in therapy of 88 HIV-1-infected patients was analyzed retrospectively, relating the genotypic resistance profile at baseline to the evolut
- Enhancement of HIV type 1 antigen-specific CD4+ T cell memory in subjects with chronic HIV type 1 infection receiving an HIV type 1 immunogen.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):539-47. Unique Identifier : AIDSLINE MED/20236902
- Maino VC; Suni MA; Wormsley SB; Carlo DJ; Wallace MR; Moss RB; Becton Dickinson Immunocytometry Systems, San Jose, California; 95131, USA.
- We examined HIV-1 specific memory helper T immune responses in chronically HIV-infected subjects who received an immune-based therapy (HIV-1 immunogen, Remune). Subjects in this study exhibited significant increases (p
- Expression of the novel T cell activation molecule hpH4 in HIV-infected patients: correlation with disease status.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):549-57. Unique Identifier : AIDSLINE MED/20236903
- Lucia MB; Buonfiglio D; Bottarel F; Bensi T; Rutella S; Rumi C; Ortona L; Janeway CA Jr; Cauda R; Dianzani U; Department of Infectious Diseases, Catholic University of Rome,; Italy.
- We have described hpH4, a surface glycoprotein selectively expressed by activated T cells and mature thymocytes and displaying weak lateral association with CD4. The hpH4 expression pattern and biochemical features, together with analysis of its tryptic digest by peptide mass searching using MALDI-MS, suggested that i
- Decreased HIV-associated T cell apoptosis by HIV protease inhibitors.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):559-67. Unique Identifier : AIDSLINE MED/20236904
- Phenix BN; Angel JB; Mandy F; Kravcik S; Parato K; Chambers KA; Gallicano K; Hawley-Foss N; Cassol S; Cameron DW; Badley AD; Department of Biochemistry, Microbiology, and Immunology,; University of Ottawa, Ontario, Canada.
- Antiretroviral treatment of patients infected with HIV results in improvements in CD4+ T cell number. Emerging evidence suggests that some of the improvements in CD4+ T cell number that occur in response to protease inhibitor (PI) therapy may not be accounted for solely by enhanced viral suppression, implying that PI
- Molecular characterization of feline interleukin 16: chemotactic activity and effect on feline immunodeficiency virus infection and/or replication.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):569-75. Unique Identifier : AIDSLINE GENBANK/AF003701
- Leutenegger CM; Huder JB; Mislin CN; Lahrtz F; Hofmann-Lehmann R; Pedersen NC; Lutz H; Department of Internal Veterinary Medicine, University of Zurich,; Switzerland. cmleutenegger@ucdavis.edu
- Interleukin 16 (IL-16) has been shown to diminish HIV and SIV replication through inhibition of HIV and SIV mRNA transcription. To evaluate its role in the FIV cat model, we cloned and expressed feline IL-16 and determined its ability to induce chemotaxis as well as to inhibit FIV replication in cultured PBMCs. Sequen
- Construction of an SIV/HIV type 1 chimeric virus with the human interleukin 6 gene and its production of interleukin 6 in monkey and human cells.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):577-82. Unique Identifier : AIDSLINE MED/20236906
- Haga T; Kuwata T; Kozyrev I; Kwofie TB; Hayami M; Miura T; Laboratory of Viral Pathogenesis, Institute for Virus Research,; Kyoto University, Japan.
- The switch from a Th1- to a Th2-type cytokine response is reported to be involved in human immunodeficiency virus (HIV) disease progression. To study the effect of IL-6, one of the Th2-type cytokines, on AIDS pathogenesis, we constructed an SIV/HIV-1 chimeric virus (SHIV) having the human IL-6 gene (SHIV-IL6) SHIV-IL6
- IgG subclass distribution in serum and various mucosal fluids of HIV type 1-infected subjects.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):583-94. Unique Identifier : AIDSLINE MED/20236907
- Raux M; Finkielsztejn L; Salmon-Ceron D; Bouchez H; Excler JL; Dulioust E; Grouin JM; Sicard D; Blondeau C; Aventis Pasteur, Val de Reuil, France. Maurice.Raux@aventis.com
- We measured total IgG1, IgG2, IgG3, and IgG4 concentrations by ELISA in serum (S), total saliva (TS), cervicovaginal secretions (CVS), seminal secretions (SPE), and rectal secretions (RS) from either CDC II/III HIV-1-infected subjects or healthy volunteers. Human serum albumin was measured in parallel to calculate the
- False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigens.
- Unique Identifier : AIDSLINE MED/20236908 P
- Jackson S; Prince S; Kulhavy R; Mestecky J
- Identification of all HIV type 1 group M subtypes in Senegal, a country with low and stable seroprevalence.
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):603-9. Unique Identifier : AIDSLINE +
- Toure-Kane C; Montavon C; Faye MA; Gueye PM; Sow PS; Ndoye I; Gaye-Diallo A; Delaporte E; Peeters M; Mboup S; Virology, Laboratory, Hopital Le Dantec, Dakar, Senegal.
- A total of 343 HIV-1-positive samples obtained between June 1996 and March 1999 was genetically characterized in the envelope region by HMA and/or sequencing. The env subtype distribution was as follows: 290 (84.6%) A, 22 (6.5%) B, 16 (4.7%) C, 8 (2.5%) D, 1 (0.03%) E, 1 (0.03%) F1, 4 (1.2%) G, and 1 (0.03%) H. For 77
- Large-scale ex vivo expansion of primary T lymphocytes in late-stage AIDS patients [letter]
- AIDS Res Hum Retroviruses. 2000 Apr 10;16(6):611-2. Unique Identifier : AIDSLINE MED/20236910
- Shimizu N; Sekine T; Itoh K; Nakamura T; Iwamoto A; Satoh Y; Yamamoto K
- Treatment of HIV-associated invasive anal cancer with combined chemoradiation.
- Eur J Cancer. 2000 Apr;36(6):754-8. Unique Identifier : AIDSLINE MED/20227632
- Cleator S; Fife K; Nelson M; Gazzard B; Phillips R; Bower M; Department of Radiotherapy, Charing Cross Hospital, Fulham Palace; Road, London, UK.
- There is an increased frequency of invasive anal cancer in HIV-seropositive men. Early treatment strategies in this patient group employed reduced dosages of chemotherapy or radiotherapy alone to reduce toxicity. Since 1989 we have used combined modality treatment consisting of chemotherapy 5-fluorouracil (5-FU) and m
- Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes.
- Br J Haematol. 2000 Mar;108(3):488-95. Unique Identifier : AIDSLINE MED/20223061
- Durig J; Giese A; Schulz-Schaeffer W; Rosenthal C; Schmucker U; Bieschke J; Duhrsen U; Kretzschmar HA; Department of Haematology, University Hospital Essen, Germany.
- The cellular isoform of the prion protein (PrPC) is a cell surface glycoprotein that has recently been shown to play a role in haemopoietic cell activation and proliferation. We have characterized the constitutive expression of PrPC on human peripheral blood (pB) cell populations, using PrP-specific antibodies in a mu
- T cells and fibroblasts in affected extraocular muscles in early and late thyroid associated ophthalmopathy [see comments]
- Unique Identifier : AIDSLINE MED/20245340 P
- Pappa A; Lawson JM; Calder V; Fells P
- Optic neuropathy as the presenting feature of HIV infection: recovery of vision with highly active antiretroviral therapy [letter]
- Unique Identifier : AIDSLINE MED/20300015
- Goldsmith P; Jones RE; Ozuzu GE; Richardson J; Ong EL
- A delay-differential equation model of HIV infection of CD4(+) T-cells.
- Math Biosci. 2000 May;165(1):27-39. Unique Identifier : AIDSLINE MED/20265876
- Culshaw RV; Ruan S; Department of Mathematics and Statistics, Dalhousie University,; Halifax, Nova Scotia, Canada. rebecca@mscs.dal.ca
- A.S. Perelson, D.E. Kirschner and R. De Boer (Math. Biosci. 114 (1993) 81) proposed an ODE model of cell-free viral spread of human immunodeficiency virus (HIV) in a well-mixed compartment such as the bloodstream. Their model consists of four components: uninfected healthy CD4(+) T-cells, latently infected CD4(+) T-ce
- Viral hepatitis C.
- J Assoc Acad Minor Phys. 1998;9(4):59-64. Unique Identifier : AIDSLINE MED/20285749
- Leevy CB; Zierer KG; Leevy CM; UMDNJ-New Jersey Medical School Liver Center, Newark 07103, USA.
- Identification of a cDNA clone and the genome of hepatitis C virus in 1988-1989 allowed the development of clinical tests that are now used to detect and quantify hepatitis C virus. This has largely eliminated post-transfusion hepatitis C virus infection; however, the overall incidence of chronic hepatitis C and its c
- Esophageal candidoma in a patient with acquired immunodeficiency syndrome.
- J Assoc Acad Minor Phys. 1998;9(4):69-71. Unique Identifier : AIDSLINE MED/20285751
- Bhalodia MV; Vega KJ; DaCosta J; Trotman BW; Department of Medicine, UMDNJ-New Jersey Medical School and; University Hospital, Newark 07103-2714, USA.
- Oral thrush and esophagitis caused by Candida are common in patients infected with the human immunodeficiency virus. We present the case of a 33-year-old man with acquired immunodeficiency syndrome who developed dysphagia during a hospitalization for pneumonia. Signs and sympto
- The ethics of unlinked anonymous testing. Surveys provide essential information [letter]
- BMJ. 2000 May 6;320(7244):1275. Unique Identifier : AIDSLINE MED/20259342
- Nicoll A; Gill N; Goldberg D; Peckham C
- The ethics of unlinked anonymous testing. Testing need not stop [letter]
- BMJ. 2000 May 6;320(7244):1275-6. Unique Identifier : AIDSLINE MED/20303705
- Foex BA
- The possible role of interleukin-16 in the low incidence of HIV infection in patients with systemic lupus erythematosus [letter]
- Lupus. 2000;9(2):155-6. Unique Identifier : AIDSLINE MED/20246697
- Sekigawa I; Lee S; Kaneko H; Iida N; Hashimoto H; Hirose S; Kaneko Y
- Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.
- Pharmacogenetics. 2000 Mar;10(2):171-82. Unique Identifier : AIDSLINE MED/20222642
- O'Neil WM; Drobitch RK; MacArthur RD; Farrough MJ; Doll MA; Fretland AJ; Hein DW; Crane LR; Svensson CK; Department of Pharmaceutical Sciences, Wayne State University,; Detroit, Michigan 48202-3489, USA.
- The acetylator phenotype and genotype of AIDS patients, with and without an acute illness, was compared with that of healthy control subjects (30 per group). Two probe drugs, caffeine and dapsone, were used to determine the phenotype in the acutely ill cohort. Polymerase chain reaction amplification and restriction fr
- AIDS and HIV infection in the United Kingdom: monthly report.
- Commun Dis Rep CDR Wkly. 2000 Apr 28;10(17):157-60. Unique Identifier : AIDSLINE MED/20272628
- Predicting the outcome of therapy for pulmonary tuberculosis.
- Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1076-80. Unique Identifier : AIDSLINE MED/20227905
- Wallis RS; Perkins MD; Phillips M; Joloba M; Namale A; Johnson JL; Whalen CC; Teixeira L; Demchuk B; Dietze R; Mugerwa RD; Eisenach K; Ellner JJ; Case Western Reserve University, Cleveland, Ohio 44106, USA.; rsw2@po.cwru.edu
- Patients vary considerably in their response to treatment of pulmonary tuberculosis. Although several studies have indicated that adverse outcomes are more likely in those patients with delayed sputum sterilization, few tools are available to identify those patients prospectively. In this study, multivariate models we
- A new preadmission staging system for predicting inpatient mortality from HIV-associated Pneumocystis carinii pneumonia in the early highly active antiretroviral therapy (HAART) era.
- Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1081-6. Unique Identifier : AIDSLINE MED/20227906
- Arozullah AM; Yarnold PR; Weinstein RA; Nwadiaro N; McIlraith TB; Chmiel JS; Sipler AM; Chan C; Goetz MB; Schwartz DN; Bennett CL; Brockton/West Roxbury VA Medical Center, West Roxbury,; Massachusetts, USA.
- A common severe complication of human immunodeficiency virus (HIV) infection has been Pneumocystis carinii pneumonia (PCP). Recently, with increasing use of PCP prophylaxis and multidrug antiretroviral therapy, the clinical manifestations of HIV infection have changed dramatically and the predictors of inpatient morta
- Airway inflammation driven by antigen-specific resident lung CD4(+) T cells in alphabeta-T cell receptor transgenic mice.
- Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1340-8. Unique Identifier : AIDSLINE MED/20227944
- Knott PG; Gater PR; Bertrand CP; Inflammatory Diseases Unit, Roche Bioscience, Palo Alto,; California 94304, USA.
- CD4(+) T cells are thought to play a major role in the initiation and perpetuation of T helper cell, type 2 (Th2)-like allergic airway inflammation. However, it is not clear whether activation of resident antigen-specific CD4(+) T cells is in itself sufficient to induce such a phenotype. Using ovalbumin (OVA)-specific
- Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
- Brain Res. 2000 Apr 7;861(1):105-16. Unique Identifier : AIDSLINE MED/20216722
- Milligan ED; Mehmert KK; Hinde JL; Harvey LO; Martin D; Tracey KJ; Maier SF; Watkins LR; Department of Psychology, University of Colorado at Boulder,; Campus Box 345, Boulder, CO 80309-0345, USA.; emilligan@clipr.colorado.edu
- Astrocytes and microglia in the spinal cord have recently been reported to contribute to the development of peripheral inflammation-induced exaggerated pain states. Both lowering of thermal pain threshold (thermal hyperalgesia) and lowering of response threshold to light tactile stimuli (mechanical allodynia) have bee
- Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
- Brain Res. 2000 Apr 7;861(1):8-15. Unique Identifier : AIDSLINE MED/20216712
- Pugh CR; Johnson JD; Martin D; Rudy JW; Maier SF; Watkins LR; Department of Psychology, University of Colorado, Boulder, CO; 80309, USA. rachal@psych.colorado.edu
- Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea
- The slime loosener strikes again! [comment]
- Unique Identifier : AIDSLINE MED/20220774
- Luft FC; Franz-Volhard-Klinik, Humboldt University of Berlin, Berlin-Buch,; Germany. luft@fvk-berlin.de
- Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials [see comments]
- Unique Identifier : AIDSLINE MED/20220780
- Breitkreutz R; Pittack N; Nebe CT; Schuster D; Brust J; Beichert M; Hack V; Daniel V; Edler L; Droge W
- To determine the therapeutic effect of sulfur amino acid supplementation in HIV infection we randomized 40 patients with antiretroviral therapy (ART; study 1) and 29 patients without ART (study 2) to treatment for 7 months with N-acetyl-cysteine or placebo at an individually adjusted dose according to a defined scheme
- Interaction between indinavir and St. John's wort reported [news]
- Am J Health Syst Pharm. 2000 Apr 1;57(7):625-6. Unique Identifier : AIDSLINE MED/20229298
- Miller JL
- 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine.
- Gene Ther. 2000 Apr;7(8):694-702. Unique Identifier : AIDSLINE MED/20262159
- Arai H; Xin KQ; Hamajima K; Lu Y; Watabe S; Takahashi T; Toda S; Okuda K; Kudoh I; Suzuki M; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Yokohama, Japan.
- From a series of preclinical studies and animal experiments, we have been able to demonstrate that DNA vaccines are a promising tool in strategies for protecting hosts from a variety of infectious diseases. Since the promoter activity of the human cytomegalovirus immediate-early pr
- Altered expression of natural killer cell inhibitory receptors (KIRs) on T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients.
- Sarcoidosis Vasc Diffuse Lung Dis. 2000 Mar;17(1):54-9. Unique Identifier : AIDSLINE MED/20210356
- Mizuki M; Eklund A; Grunewald J; Health Care Center, Oita Medical University, Japan.
- BACKGROUND AND AIM OF THE WORK: The role for natural killer cell inhibitory receptors (KIRs) on T cells is not fully understood, but signalling through KIRs on T cells may inhibit T cell receptor mediated activation, and KIR expression has been suggested to be one mechanism of controlling T cell mediated immune respon
- Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas.
- Unique Identifier : AIDSLINE MED/20237466
- Zhuang SM; Wiseman RW; Soderkvist P
- The pRb pathway plays a key role in controlling the G1/S transition in cell cycle progression. Aberrations of various components of the pRb pathway, such as retinoblastoma protein and its upstream actors including cyclin D1, cyclin dependence kinase-4 and p16/p15 cyclin dependent kinase inhibitors, have
- Increased burn-induced immunosuppression in lipopolysaccharide-resistant mice.
- Cell Immunol. 2000 Mar 15;200(2):65-75. Unique Identifier : AIDSLINE MED/20218893
- Jobin N; Garrel DR; Bernier J; Centre hospitalier de l'Universite de Montreal; (CHUM)-Hotel-Dieu, Centre des grands brules, Montreal, PQ,; Canada.
- Severe burns induce a state of immunosuppression, and the inflammatory response after burn injury may play a role in this phenomenon. This study examined the effect of the inflammatory response to endotoxin on burn-induced immunosuppression and oxidative stress. An endotoxin-resistant mouse strain (C3H/HeJ) and a norm
- The autoimmune accelerating yaa mutation does not accelerate murine AIDS.
- Cell Immunol. 2000 Mar 15;200(2):76-80. Unique Identifier : AIDSLINE MED/20218894
- Hugin AW; Fossati-Jimack L; Izui S; Department of Dermatology, University Hospital, Geneva,; Switzerland.
- Murine acquired immunodeficiency syndrome (MAIDS) is characterized by lymphoproliferation, polyclonal B cell activation resulting in the production of autoantibodies, and a progressive immunodeficiency. These are all hallmarks of some autoimmune diseases. Yaa is a Y-chromosome-linked gene that accelerates autoimmune d
- [General practice patterns in hepatitis C virus mass screening in the Lyons region]
- Sante Publique. 1999 Dec;11(4):513-25. Unique Identifier : AIDSLINE MED/20258512
- Sahajian F; Caillat-Vallet E; Bailly F; Excler G; Trepo C; Fabry J; Sepetjan M; ADHEC, Laboratoire d'Epidemiologie et de Sante Publique,; Faculte de medecine Domaine Rockefeller, Lyon, France.
- A study on the screening practices for hepatitis C was carried out among a sample of 786 general practitioners in the Lyon region. The sample comprised three groups: 272 doctors who had participated in a study of this screening, 242 doctors who had not responded to the request for participation, and 272 doctors who ha
- Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine.
- Toxicol Sci. 2000 Apr;54(2):322-9. Unique Identifier : AIDSLINE MED/20234847
- Meng Q; Su T; Olivero OA; Poirier MC; Shi X; Ding X; Walker VE; Wadsworth Center, New York State Department of Health, Albany; 12201-0509, USA.
- 3 -Azido-3 -deoxythymidine ( AZT ), a thymidine analogue widely used in the treatment of AIDS patients and for prevention of the onset of AIDS in HIV-seropositive individuals, causes tumors in mice exposed as adults or in utero. The purpose of this stud
- The effects of alternative treatments for HIV disease on recommended pharmacological regimens.
- Int J Antimicrob Agents. 2000 Feb;13(4):281-5. Unique Identifier : AIDSLINE MED/20216018
- Manfredi R; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, S. Orsola Hospital, Italy.
- The use of alternative treatments for HIV disease was assessed before and after the introduction of highly active antiretroviral therapy (HAART) by the use of a standardised questionnaire. These data were related to epidemiological, clinical and laboratory parameters and compliance levels to recommended antiretroviral
- An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
- Acta Crystallogr D Biol Crystallogr. 2000 Apr;56 ( Pt 4):381-8. Unique Identifier : AIDSLINE MED/20207109
- Munshi S; Chen Z; Yan Y; Li Y; Olsen DB; Schock HB; Galvin BB; Dorsey B; Kuo LC; Department of Antiviral Research, Merck Research Laboratories,; West Point, PA 19486, USA. sanjeev_munshi@merck.com
- Structures of the complexes of HIV protease inhibitor L--756,423 with the HIV-1 wild-type protease and of the inhibitors Indinavir , L-739,622 and Saquinavir with the mutant protease (9X) containing nine point mutations (Leu10Val, Lys20Met, Leu24Ile, S
- Oral supplements as adjunctive treatment to nutritional counseling in malnourished HIV-infected patients: randomized controlled trial.
- Clin Nutr. 1999 Dec;18(6):371-4. Unique Identifier : AIDSLINE MED/20102920
- Schwenk A; Steuck H; Kremer G; Klinik I fur Innere Medizin, University of Cologne, Cologne,; Germany.
- AIMS:To compare nutritional counseling with and without oral supplements in HIV-infected patients with recent weight loss. DESIGN: Randomized non-blinded controlled trial, stratified for change in antiretroviral treatment at baseline. PATIENTS: HIV-infected patients with recent weight loss (> 5% of total, and >3% in t
- Thiamin deficiency in HIV-positive patients: evaluation by erythrocyte transketolase activity and thiamin pyrophosphate effect.
- Clin Nutr. 1999 Dec;18(6):375-8. Unique Identifier : AIDSLINE MED/20102921
- Muri RM; Von Overbeck J; Furrer J; Ballmer PE; Departments of Neurology, University of Bern, Bern, Switzerland.
- BACKGROUND AND AIMS: The aim of the study was to determine the thiamin status in HIV-positive patients. METHODS: Measurement of erythrocyte transketolase activity (ETK) and thiaminpyrophosphate (TPP) effect in 55 consecutive HIV-positive patients of a specialized outpatient clinic were grouped into five groups accordi
- An analysis of the catalytic cycle of HIV-1 reverse transcriptase: opportunities for chemotherapeutic intervention based on enzyme inhibition.
- Curr Pharm Des. 2000 Mar;6(5):547-67. Unique Identifier : AIDSLINE MED/20251319
- Furman PA; Painter GR; Anderson KS; Triangle Pharmaceuticals, 4 University Place, 4611 University; Drive, Durham, NC 27707, USA.
- This review describes each of the steps in the HIV-1 reverse transcriptase catalytic cycle and evaluates each of these steps as a potential point of inhibition of the enzyme and consequently viral replication. To date, two classes of approved drugs act on the reverse transcriptase. They are: (1) the nucleoside reverse
- Anti-HIV-1 integrase drugs: how far from the shelf?
- Curr Pharm Des. 2000 Mar;6(5):569-84. Unique Identifier : AIDSLINE MED/20251320
- Pani A; Marongiu ME; Dipartimento di Biologia Sperimentale, Sezione di Microbiologia,; Universita' degli Studi di Cagliari, Italy.
- Chemotherapy of HIV-1 infection/AIDS currently employs inhibitors of two products of the viral pol gene, the reverse transcriptase and protease enzymes. However, a third product of the pol gene is essential for retroviral multiplication, the integrase. As no cellular homologue of HIV integrase has been described, pote
- Design of anti-HIV compounds: from nucleoside to nucleoside 5'-triphosphate analogs. Problems and perspectives.
- Curr Pharm Des. 2000 Mar;6(5):585-98. Unique Identifier : AIDSLINE MED/20251321
- Kukhanova M; Krayevsky A; Prusoff W; Cheng YC; Engelhardt Institute of Molecular Biology, Russian Academy of; Sciences, 32 Vavilov St, Moscow, 117984. kukhan@medmail.com
- To date, human immunodeficiency virus infection remains incurable although a variety of antiviral agents have been identified and characterized. Even though nucleoside analogs have been the most successful prodrugs, there remains the need to develop new compounds that exhibit a more favorable toxicity profile, less su
- The role of vascular endothelial growth factor (VEGF) in AIDS-related Kaposi's sarcoma.
- Oncologist. 2000;5 Suppl 1:28-31. Unique Identifier : AIDSLINE MED/20264296
- Arasteh K; Hannah A; Auguste-Viktoria-Krankenhaus, Berlin, Germany.; arasteh@avk.b.shuttle.de
- Kaposi s sarcoma (KS) is the most common neoplasm associated with human immunodeficiency virus-1 (HIV-1) infection. KS involves the skin and mucous membranes as well as other organs and can lead to tumor-associated edema and ulcerations. Despite therapy with highly active antiviral agents, most patients with HIV-1-rel
- Surgeons who test positive for hepatitis C should not be transferred to low risk duties.
- Rev Med Virol. 2000 Mar-Apr;10(2):79-82. Unique Identifier : AIDSLINE MED/20180467
- Cockcroft A; Department of Occupational Health, Royal Free Hampstead NHS; Trust, London, UK.
- Current UK guidelines allow surgeons who are antibody-positive for hepatitis C virus (HCV) to continue performing exposure-prone procedures (EPPs) unless they have been shown to transmit HCV to a patient. Given the low rate of recognised transmission from surgeon to patient, this recommendation is probably reasonable
- Endoneurial vasculitis and tubuloreticular inclusions in peripheral nerve biopsy.
- Clin Neuropathol. 2000 Mar-Apr;19(2):70-6. Unique Identifier : AIDSLINE MED/20210858
- Midroni G; Cohen SM; Bilbao JM; Division of Neurology, St. Michael's Hospital, University of; Toronto, Ontario, Canada.
- We describe 3 patients in whom nerve biopsy revealed endothelial tubuloreticular inclusions in association with peripheral nerve endoneurial vasculitis. Two of the patients had systemic lupus erythematosus (SLE), while the third was HIV-positive. Review of our biopsy material featuring the much more common finding of
- [The recent advances of HAM/TSP research]
- Rinsho Shinkeigaku. 1999 Dec;39(12):1200-2. Unique Identifier : AIDSLINE MED/20251674
- Osame M; 3rd Department of Internal Medicine, Faculty of Medicine,; Kagoshima University.
- The ninth international conference on HTLVs and related disorders was held on April 5-9, 1999 at Kagoshima, Japan under the conference chairperson, Dr. Mitsuhiro Osame. In this meeting, world-wide epidemiological data on HTLV-I carriers, ATL patients, and HAM/TSP patients were summa
- T(H)1 to T(H)2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linked immunosorbent assay under nonstimulated conditions.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):287-94. Unique Identifier : AIDSLINE MED/20294739
- Altfeld M; Addo MM; Kreuzer KA; Rockstroh JK; Dumoulin FL; Schliefer K; Leifeld L; Sauerbruch T; Spengler U; Department of Internal Medicine I, University of Bonn, Germany.; MALTFELD@partners.org
- BACKGROUND: Dysregulation of cytokines has been implicated in the pathogenesis of HIV infection. Therefore, we determined tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-4, IL-10, and interferon-gamma (IFN-gamma) mRNA and serum levels in HIV-infected patients under nonstimulated conditions. M
- Depressive symptoms decline among persons on HIV protease inhibitors.
- Unique Identifier : AIDSLINE MED/20294740
- Low-Beer S; Chan K; Yip B; Wood E; Montaner JS; O'Shaughnessy MV; Hogg RS
- OBJECTIVE: To ascertain whether initiation of protease inhibitors was associated with a change in depressive symptoms among persons
- Impact of zidovudine-based triple combination therapy on an AIDS drug assistance program.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):302-13. Unique Identifier : AIDSLINE MED/20294741
- Mauskopf JA; Tolson JM; Simpson KN; Pham SV; Albright J; Research Triangle Institute, Research Triangle Park, North; Carolina, USA.
- A static deterministic model was used to estimate the effect of the shift to a triple combination therapeutic standard on the annual AIDS Drug Assistance Program (ADAP) budget, total medical care expenditures, and population health outcomes for New York (NY) state ADAP enrollees. The model used opportunistic disease i
- Dissociation of immunologic and virologic responses to highly active antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):314-20. Unique Identifier : AIDSLINE MED/20294742
- Fessel WJ; Krowka JF; Sheppard HW; Gesner M; Tongson S; Weinstein S; Ascher M; Kwok S; Christopherson C; Kaiser Permanente Medical Center, San Francisco, California; 94115, USA.
- OBJECTIVE: Immunologic markers, levels of HIV DNA, and infectious HIV were compared in partial responders (PR) to HAART who had high plasma HIV RNA levels but stable or increasing levels of CD4+ peripheral blood mononuclear cells (PBMC), and patients with complete failure (CF) who had very low or decreasing levels of
- Improved antioxidant status among HIV-infected injecting drug users on potent antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):321-6. Unique Identifier : AIDSLINE MED/20294743
- Tang AM; Smit E; Semba RD; Shah N; Lyles CM; Li D; Vlahov D; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University', Baltimore, Maryland, USA.
- Low serum antioxidant levels in HIV-infected people have been attributed to altered metabolism associated with excess oxidative stress. We conducted a study to examine serum antioxidant levels in 175 HIV-positive and 210 HIV-negative injecting drug users (IDUs) in Baltimore, Maryland. At the time of data collection, 3
- The HIV epidemic in the Amazon Basin is driven by prototypic and recombinant HIV-1 subtypes B and F.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):327-31. Unique Identifier : AIDSLINE GENBANK/AF076316
- Vicente AC; Otsuki K; Silva NB; Castilho MC; Barros FS; Pieniazek D; Hu D; Rayfield MA; Bretas G; Tanuri A; Genetics Department, Instituto Oswaldo Cruz, Rio de Janeiro,; Brazil.
- This paper describes genetic subtypes of HIV-1 found in blood samples from 31 HIV-1-infected people who visited the Counseling and Testing AIDS Center of Instituto de Medicina Tropical in Manaus, Brazil . Manaus, the main city in Brazil s Amazon Basin, is also the closest urban conn
- Mortality of HIV-positive and HIV-negative heroin abusers as a function of duration of injecting drug use.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):332-8. Unique Identifier : AIDSLINE MED/20294745
- Muga R; Roca J; Egea JM; Tor J; Sirera G; Rey-Joly C; Munoz A; Infectious Disease Unit, Hospital Universitario Germans Trias i; Pujol, Barcelona, Spain. rmuga@ns.hugtip.scs.es
- OBJECTIVE: To determine the incidence of mortality of injecting drug users as a function of the duration of injecting drugs and HIV status, and to assess how these effects vary according to age at initiation and calendar period (before and after 1992). METHODS AND DESIGN: Cohort of 376 intravenous heroin users admitte
- Repeat screening for HIV: when to test and why.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):339-45. Unique Identifier : AIDSLINE MED/20294746
- Kaplan EH; Satten GA; Management Sciences and Public Health, Yale School of Management,; New Haven, Connecticut, 06520-8200, USA. edward.kaplan@yale.edu
- This paper presents models for repeat HIV screening under conditions of constant low HIV incidence. The models reveal a direct link between the prevalence of undetected HIV infection and the screening interval between repeat HIV tests. We show how to select screening intervals that either achieve a given HIV prevalenc
- Identifying human herpesvirus 8 infection: performance characteristics of serologic assays.
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):346-54. Unique Identifier : AIDSLINE MED/20294747
- Engels EA; Whitby D; Goebel PB; Stossel A; Waters D; Pintus A; Contu L; Biggar RJ; Goedert JJ; Viral Epidemiology Branch, Division of Cancer Epidemiology and; Genetics, National Cancer Institute, Rockville, Maryland 20852,; USA. engelse@exchange.nih.gov
- Epidemiologic studies of infection with the oncogenic human herpesvirus 8 (HHV-8) depend on serologic methods to diagnose infection. However, optimal strategies for identifying HHV-8 infection remain undefined. We therefore evaluated four enzyme-linked immunoassays (EIAs) and one immunofluorescence assay (IFA) using s
- Lipodystrophy: results of a data evaluation of patients receiving nelfinavir-containing combination therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):355-6. Unique Identifier : AIDSLINE MED/20294748
- Lewis RH; Popescu M
- Hepatitis B virus seroconversion in HIV-HBV coinfected patients treated with highly active antiretroviral therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):356-7. Unique Identifier : AIDSLINE MED/20294749
- Piroth L; Grappin M; Buisson M; Duong M; Portier H; Chavanet P
- Dietary problems in African HIV-1-infected adults, Abidjan, Cote d'Ivoire. COTRIMO-CI Study Group [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):357-8. Unique Identifier : AIDSLINE MED/20294750
- Castetbon K; Anglaret X; Attia A; Mahassadi A; Malvy D; Dabis F
- RNA viral load test for early diagnosis of vert