Multinucleated giant cell formation by microglia: induction by interleukin (IL)-4 and IL-13. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Multinucleated giant cell formation by microglia: induction by interleukin (IL)-4 and IL-13.

Brain Res. 1999 Dec 4;849(1-2):239-43. Unique Identifier : AIDSLINE MED/20074719
Suzumura A; Tamaru T; Yoshikawa M; Takayanagi T; Department of Neurology, Nara Medical University, 840 Shijo-cho,; Kashihara, Nara, Japan. asuzumur@naramed-u.ac.jp

Abstract: To investigate the cellular origin and the mechanisms of multinucleated giant cell (MGC) formation in the CNS, various cytokines were applied to isolated murine microglia. All the single cytokines failed to induce MGC. However, interleukin (IL)-13 and IL-4 induced microglial MGC formation in the presence of colony stimulating factors, which was inhibited by either anti-IL-13 or anti-fms antibody. T helper 2 (Th2)-derived cytokines can induce MGC formation even in the absence of infectious agents.

Keywords: JOURNAL ARTICLE Animal Animals, Newborn Brain/CYTOLOGY/IMMUNOLOGY Cells, Cultured Colony-Stimulating Factors/PHARMACOLOGY Giant Cells/*CYTOLOGY/DRUG EFFECTS Interleukin-13/*PHARMACOLOGY Interleukin-4/*PHARMACOLOGY Mice Mice, Inbred C57BL Microglia/*CYTOLOGY/DRUG EFFECTS Support, Non-U.S. Gov't Th2 Cells/IMMUNOLOGY Transforming Growth Factor beta/PHARMACOLOGY

KWDjournalarticleanimalanimals,newbornbrain/cytology/immunologycells,culturedcolony-stimulatingfactors/pharmacologygiantcells/KWDcytology/drugeffectsinterleukin-13/KWDpharmacologyinterleukin-4/KWDpharmacologymicemice,inbredc57blmicroglia/KWDcytology/drugeffectssupport,non-uKWDsKWDgov'tth2cells/immunologytransforminggrowthfactorbeta/pharmacology
000430
A0040912

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