Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses.

Immunity. 1999 Dec;11(6):733-42. Unique Identifier : AIDSLINE MED/20090321
Selin LK; Lin MY; Kraemer KA; Pardoll DM; Schneck JP; Varga SM; Santolucito PA; Pinto AK; Welsh RM; Department of Pathology, University of Massachusetts Medical; School, Worcester 01655, USA.

Abstract: Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.

Keywords: JOURNAL ARTICLE Animal Antigens, Viral/IMMUNOLOGY Cell Line, Transformed CD8-Positive T-Lymphocytes/*IMMUNOLOGY Dimerization Epitopes, T-Lymphocyte/*IMMUNOLOGY H-2 Antigens/IMMUNOLOGY IgG/IMMUNOLOGY Immunodominant Epitopes/*IMMUNOLOGY Immunologic Memory/*IMMUNOLOGY Interferon Type II/ANALYSIS Lymphocytic Choriomeningitis Virus/IMMUNOLOGY Major Histocompatibility Complex/IMMUNOLOGY Mice Mice, Inbred BALB C Mice, Inbred C57BL Muromegalovirus/IMMUNOLOGY Pichinde Virus/IMMUNOLOGY Receptors, Antigen, T-Cell, alpha-beta/IMMUNOLOGY Staining Support, U.S. Gov't, P.H.S. Vaccinia Virus/IMMUNOLOGY Virus Diseases/*IMMUNOLOGY

KWDjournalarticleanimalantigens,viral/immunologycellline,transformedcd8-positivet-lymphocytes/KWDimmunologydimerizationepitopes,t-lymphocyte/KWDimmunologyh-2antigens/immunologyigg/immunologyimmunodominantepitopes/KWDimmunologyimmunologicmemory/
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A0040908

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