MHC-restricted protection of cats against FIV infection by adoptive transfer of immune cells from FIV-vaccinated donors. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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MHC-restricted protection of cats against FIV infection by adoptive transfer of immune cells from FIV-vaccinated donors.

Cell Immunol. 1999 Nov 25;198(1):30-43. Unique Identifier : AIDSLINE MED/20080780
Pu R; Omori M; Okada S; Rine SL; Lewis BA; Lipton E; Yamamoto JK; Department of Pathobiology, College of Veterinary Medicine,; University of Florida, Gainesville, Florida 32611, USA.

Abstract: The role of cellular immunity in vaccine protection against FIV infection was evaluated using adoptive cell transfer studies. Specific-pathogen-free cats received two adoptive transfers of washed blood cells from either vaccinated or unvaccinated donors with varying MHC compatibility at 1-week intervals, and a homologous FIV(Pet) challenge 1 day after the first adoptive transfer. FIV-specific CTL, IFN-gamma production, and proliferation responses were detected in the PBMC from the vaccinated donors. Seven of eleven (64%) recipients of cells from half-matched/vaccinated donors remained negative for FIV-antibodies after FIV challenge and four of those were completely protected. Two of two recipients of cells from MHC-identical/vaccinated donors were completely protected. All recipients of cells from unrelated/vaccinated, half-matched/unvaccinated, or unrelated/unvaccinated donors were unprotected. Thus, protection mediated by adoptive transfer of immunocytes from vaccinated cats was MHC-restricted, occurred in the absence of antiviral humoral immunity, and correlated with the transfer of cells with FIV-specific CTL and T-helper activities. Copyright 1999 Academic Press.

Keywords: JOURNAL ARTICLE Adoptive Transfer/*METHODS/STATISTICS & NUMER DATA Animal Antibodies, Viral/BIOSYNTHESIS Bone Marrow Transplantation/IMMUNOLOGY/METHODS Cats Cytotoxicity, Immunologic/IMMUNOLOGY Feline Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/*PREVENTION & CONTROL/VIROLOGY Immunity, Cellular/IMMUNOLOGY Immunodeficiency Virus, Feline/*IMMUNOLOGY Interferon Type II/BIOSYNTHESIS Leukocytes, Mononuclear/IMMUNOLOGY/*TRANSPLANTATION Lymphocyte Transformation/IMMUNOLOGY Major Histocompatibility Complex/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. T-Lymphocytes, Cytotoxic/IMMUNOLOGY Tissue Donors Viral Load Viral Vaccines/*IMMUNOLOGY

KWDjournalarticleadoptivetransfer/KWDmethods/statistics&numerdataanimalantibodies,viral/biosynthesisbonemarrowtransplantation/immunology/methodscatscytotoxicity,immunologic/immunologyfelineacquiredimmunodeficiencysyndrome/KWDimmunology/KWDprevention&control/virologyimmunity,cellular/immunologyimmunodeficiencyvirus,feline/KWDimmunologyinterferontypeii/biosynthesisleukocytes,mononuclear/immunology/KWDtransplantationlymphocytetransformation/immunologymajorhistocompatibilitycomplex/KWDimmunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes,cytotoxic/immunologytissuedonorsviralloadviralvaccines/KWDimmunology
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