Presence of multiple HIV subtypes and a high frequency of subtype chimeric viruses in heterosexually infected women. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Presence of multiple HIV subtypes and a high frequency of subtype chimeric viruses in heterosexually infected women.

J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):325-32. Unique Identifier : AIDSLINE GENBANK/AF191348
Iversen AK; Learn GH; Fugger L; Gerstoft J; Mullins JI; Skinhoj P; Department of Infectious Diseases, Rigshospitalet, The National; University Hospital, Copenhagen, Denmark. aifrhm@inet.uni2.dk

Abstract: The HIV-1 subtype distribution was determined in 41 HIV-positive women (-8% of all HIV-infected women in Denmark) belonging to different risk groups. HIV p17 gag and env gene subtypes were determined by DNA sequence analysis. Five different HIV subtypes were detected across all patients. Most HIV-1-positive women of Danish origin carried subtype B viruses, and a minority had virus belonging to subtypes A or C. All injecting drug users (IDUs) were infected with HIV subtype B viruses, whereas all non-B subtypes were present in cases linked to heterosexual transmission. In contrast, all women of African origin carried non-B HIV subtypes (subtypes A, C, D, or G) regardless of transmission mode. Of these women, 21% infected with non-B HIV subtypes appeared to be infected by subtype chimeric viruses and 7% were jointly infected with viruses belonging to two different subtypes (A and C). Data demonstrate a preferential representation of non-B HIV subtypes in women infected through heterosexual contact, as well as a high degree of recombination between viruses derived from endemic areas in which several HIV subtypes predominate. Combined with the increased incidence of heterosexual transmission of HIV, the results imply that an increased subtype diversity can be anticipated in newly infected individuals.

Keywords: JOURNAL ARTICLE Female Gene Products, env/GENETICS Gene Products, gag/GENETICS Genes, env Genes, gag *Heterosexuality Human HIV Infections/ETHNOLOGY/*TRANSMISSION/*VIROLOGY HIV-1/*CLASSIFICATION/*GENETICS Male Molecular Sequence Data Phylogeny Recombination, Genetic Sequence Analysis, DNA Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.

KWDjournalarticlefemalegeneproducts,env/geneticsgeneproducts,gag/geneticsgenes,envgenes,gagKWDheterosexualityhumanhivinfections/ethnology/KWDtransmission/KWDvirologyhiv-1/KWDclassification/KWDgeneticsmalemolecularsequencedataphylogenyrecombination,geneticsequenceanalysis,dnasupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
000430
A0040861

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