A multicenter, randomized, controlled trial of three preparations of low-dose oral alpha-interferon in HIV-infected patients with CD4+ counts between 50 and 350 cells/mm(3). Division of AIDS Treatment Research Initiative (DATRI) 022 Study Group.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):348-57. Unique Identifier : AIDSLINE MED/20097662
Alston B; Ellenberg JH; Standiford HC; Muth K; Martinez A; Greaves W; Kumi J; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892-7624, USA. BA27E@NIH.GOV

Abstract: To evaluate the effectiveness of low-dose oral alpha-interferon (alpha-IFN), 247 HIV-infected study subjects received placebo, Alferon LDO, Veldona, or Ferimmune in a randomized, double-blind trial. Subjects had CD4+ counts between 50 and 350 cells/mm3 and HIV-related symptoms at entry. Study subjects rated the severity of eight symptoms using a symptom burden index (SBI). Study endpoints included changes in SBI, weight, CD4+ count, and Karnofsky score between baseline and the 24-week visit. The SBI outcome and weight were measured in 99 and 106 study subjects, respectively, at both the baseline and 24-week visits. Baseline SBI scores ranged from 5.4 to 7.9 in the four arms. No clinically important or statistically significant differences were found among the four arms with regard to SBI or weight change over the 24-week period. There were also no significant differences among the arms for CD4+ cell count and Karnofsky score. Few adverse reactions were noted in any arm, and there were no significant differences between arms. Although the trial was designed to enroll 560 study subjects and was prematurely terminated because of slow accrual and discontinuations of participants, the small differences among the arms in the primary and secondary endpoints do not support claims of efficacy for the measures studied.

Keywords: CLINICAL TRIAL JOURNAL ARTICLE MULTICENTER STUDY RANDOMIZED CONTROLLED TRIAL Administration, Oral Adult CD4 Lymphocyte Count Double-Blind Method Female Human HIV Infections/*DRUG THERAPY/IMMUNOLOGY Interferon-alpha/*THERAPEUTIC USE Male Middle Age Prospective Studies Severity of Illness Index Support, U.S. Gov't, P.H.S. Treatment Outcome

000430
A0040858

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